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Masaaki Hirobe

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Yaichiro Kotake; Ryota Taguchi; Katsuhiro Okuda; Yoko Sekiya; Yoshikazu Tasaki; Masaaki Hirobe; Shigeru Ohta
Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins.
T Ohno; Naoyuki Suzuki; T Dokoh; Yasuteru Urano; K Kikuchi; Masaaki Hirobe; T Higuchi; Tetsuo Nagano
Remarkable axial thiolate ligand effect on the oxidation of hydrocarbons by active intermediate of iron porphyrin and cytochrome P450.
M Tamura; Yasuteru Urano; Kazuya Kikuchi; T Higuchi; Masaaki Hirobe; Tetsuo Nagano
Superoxide dismutase activity of iron(II)TPEN complex and its derivatives.

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2005: Yaichiro Kotake; Ryota Taguchi; Katsuhiro Okuda; Yoko Sekiya; Yoshikazu Tasaki; Masaaki Hirobe; Shigeru Ohta
Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins.
Brain research 2005;1033(2):143-50.
2000: T Ohno; Naoyuki Suzuki; T Dokoh; Yasuteru Urano; K Kikuchi; Masaaki Hirobe; T Higuchi; Tetsuo Nagano
Remarkable axial thiolate ligand effect on the oxidation of hydrocarbons by active intermediate of iron porphyrin and cytochrome P450.
Journal of inorganic biochemistry 2000;82(1-4):123-5.
2000: M Tamura; Yasuteru Urano; Kazuya Kikuchi; T Higuchi; Masaaki Hirobe; Tetsuo Nagano
Superoxide dismutase activity of iron(II)TPEN complex and its derivatives.
Chemical & pharmaceutical bulletin 2000;48(10):1514-8.
2000: Tomoya Hirano; Masaaki Hirobe; K Kobayashi; Akira Odani; Osamu Yamauchi; M Ohsawa; Yoshinori Satow; Tetsuo Nagano
Mechanism of superoxide dismutase-like activity of Fe(II) and Fe(III) complexes of tetrakis-N,N,N',N'(2-pyridylmethyl)ethylenediamine.
Chemical & pharmaceutical bulletin 2000;48(2):223-30.
2000: T Ohe; Masaaki Hirobe; T Mashino
Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(2):110-2.
1999: T Mashino; K Okuda; T Hirota; Masaaki Hirobe; Tetsuo Nagano; M Mochizuki
Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism.
Bioorganic & medicinal chemistry letters 1999;9(20):2959-62.
1999: N Kobayashi; T Higuchi; Yasuteru Urano; Kazuya Kikuchi; Masaaki Hirobe; Tetsuo Nagano
Dipeptides containing L-arginine analogs: new isozyme-selective inhibitors of nitric oxide synthase.
Biological & pharmaceutical bulletin 1999;22(9):936-40.
1998: H Kurumatani; Kazuya Kikuchi; Tetsuo Nagano; Masaaki Hirobe; J Yamazaki; T Nagao
Real time measurement of nitric oxide released from cultured endothelial cells.
Biological & pharmaceutical bulletin 1998;21(12):1286-9.
1998: Yaichiro Kotake; Y Tasaki; Masaaki Hirobe; Shigeru Ohta
Deprenyl decreases an endogenous parkinsonism-inducing compound, 1-benzyl-1,2,3,4-tetrahydroisoquinoline in mice: in vivo and in vitro studies.
Brain research 1998;787(2):341-3.
1998: H Kawai; Y Makino; Masaaki Hirobe; Shigeru Ohta
Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: uptake by dopamine transporter and activity to induce parkinsonism.
Journal of neurochemistry 1998;70(2):745-51.
1997: H Kojima; K Kikuchi; Masaaki Hirobe; Tetsuo Nagano
Real-time measurement of nitric oxide production in rat brain by the combination of luminol-H2O2 chemiluminescence and microdialysis.
Neuroscience letters 1997;233(2-3):157-9.
1997: M Satoh; K Matsuo; H Kiriya; T Mashino; Masaaki Hirobe; I Takayanagi
Inhibitory effect of a fullerene derivative, monomalonic acid C60, on nitric oxide-dependent relaxation of aortic smooth muscle.
General pharmacology 1997;29(3):345-51.
1997: Akemi Ryu; Eiji Naru; Kumi Arakane; T Masunaga; K Shinmoto; Tetsuo Nagano; Masaaki Hirobe; S Mashiko
Cross-linking of collagen by singlet oxygen generated with UV-A.
Chemical & pharmaceutical bulletin 1997;45(8):1243-7.
1997: Naoki Umezawa; Kumi Arakane; Akemi Ryu; S Mashiko; Masaaki Hirobe; Tetsuo Nagano
Participation of reactive oxygen species in phototoxicity induced by quinolone antibacterial agents.
Archives of biochemistry and biophysics 1997;342(2):275-81.
1997: M Satoh; K Matsuo; H Kiriya; T Mashino; T Nagano; Masaaki Hirobe; I Takayanagi
Inhibitory effects of a fullerene derivative, dimalonic acid C60, on nitric oxide-induced relaxation of rabbit aorta.
European journal of pharmacology 1997;327(2-3):175-81.
1997: Yasunobu Hirata; Hiroshi Hayakawa; Masao Kakoki; Arinobu Tojo; Etsu Suzuki; Daisuke Nagata; Kenjiro Kimura; Atsuo Goto; Kazuya Kikuchi; Tetsuo Nagano; Masaaki Hirobe; Masao Omata
Receptor subtype for vasopressin-induced release of nitric oxide from rat kidney.
Hypertension 1997;29(1 Pt 1):58-64.
1997: T Ohe; T Mashino; Masaaki Hirobe
Substituent elimination from p-substituted phenols by cytochrome P450. ipso-Substitution by the oxygen atom of the active species.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(1):116-22.
1996: Yaichiro Kotake; M Yoshida; M Ogawa; Y Tasaki; Masaaki Hirobe; S Ohta
Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate.
Neuroscience letters 1996;217(1):69-71.
1996: H Nakagawa; N Nihonmatsu; S Ohta; Masaaki Hirobe
Effects of new endogenous nonprotein amino acids, 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives, on behavior of mice.
Biochemical and biophysical research communications 1996;225(3):1027-34.
1996: Kumi Arakane; Akemi Ryu; C Hayashi; T Masunaga; K Shinmoto; S Mashiko; T Nagano; Masaaki Hirobe
Singlet oxygen (1 delta g) generation from coproporphyrin in Propionibacterium acnes on irradiation.
Biochemical and biophysical research communications 1996;223(3):578-82.
1996: K Kikuchi; Tetsuo Nagano; Masaaki Hirobe
Novel detection method of nitric oxide using horseradish peroxidase.
Biological & pharmaceutical bulletin 1996;19(4):649-51.
1996: Yasunobu Hirata; Hiroshi Hayakawa; Masao Kakoki; Arinobu Tojo; Etsu Suzuki; K Kimura; Atsuo Goto; K Kikuchi; Tetsuo Nagano; Masaaki Hirobe; Masao Omata
Nitric oxide release from kidneys of hypertensive rats treated with imidapril.
Hypertension 1996;27(3 Pt 2):672-8.
1996: Kumi Arakane; Akemi Ryu; K Takarada; T Masunaga; K Shinmoto; R Kobayashi; S Mashiko; Tetsuo Nagano; Masaaki Hirobe
Measurement of 1268 nm emission for comparison of singlet oxygen (1 delta g) production efficiency of various dyes.
Chemical & pharmaceutical bulletin 1996;44(1):1-4.
1995: Yaichiro Kotake; Y Tasaki; Y Makino; S Ohta; Masaaki Hirobe
1-Benzyl-1,2,3,4-tetrahydroisoquinoline as a parkinsonism-inducing agent: a novel endogenous amine in mouse brain and parkinsonian CSF.
Journal of neurochemistry 1995;65(6):2633-8.
1995: Yasunobu Hirata; Hiroshi Hayakawa; Etsu Suzuki; K Kimura; K Kikuchi; Tetsuo Nagano; Masaaki Hirobe; Masao Omata
Direct measurements of endothelium-derived nitric oxide release by stimulation of endothelin receptors in rat kidney and its alteration in salt-induced hypertension.
Circulation 1995;91(4):1229-35.
1995: M Komuro; T Higuchi; Masaaki Hirobe
Application of chemical cytochrome P-450 model systems to studies on drug metabolism--VIII. Novel metabolism of carboxylic acids via oxidative decarboxylation.
Bioorganic & medicinal chemistry 1995;3(1):55-65.
1995: Hiroshi Hayakawa; Yasunobu Hirata; Etsu Suzuki; Masao Kakoki; K Kikuchi; Tetsuo Nagano; Masaaki Hirobe; Masao Omata
Endothelium-derived relaxing factors in the kidney of spontaneously hypertensive rats.
Life sciences 1995;56(21):PL401-8.
1994: Hiroshi Hayakawa; Yasunobu Hirata; Etsu Suzuki; K Kimura; K Kikuchi; Tetsuo Nagano; Masaaki Hirobe; Masao Omata
Long-term administration of L-arginine improves nitric oxide release from kidney in deoxycorticosterone acetate-salt hypertensive rats.
Hypertension 1994;23(6 Pt 1):752-6.
1994: T Ohe; T Mashino; Masaaki Hirobe
Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.
Archives of biochemistry and biophysics 1994;310(2):402-9.
1994: Tetsuo Nagano; T Tanaka; H Mizuki; Masaaki Hirobe
Toxicity of singlet oxygen generated thermolytically in Escherichia coli.
Chemical & pharmaceutical bulletin 1994;42(4):883-7.
1993: K Kikuchi; Tetsuo Nagano; Hiroshi Hayakawa; Yasunobu Hirata; Masaaki Hirobe
Real time measurement of nitric oxide produced ex vivo by luminol-H2O2 chemiluminescence method.
The Journal of biological chemistry 1993;268(31):23106-10.
1993: H Watanabe; M Tateyama; Taku Nagao; S Ohta; Masaaki Hirobe; Hiraku Ono
Methamphetamine antagonistic property of (+)- and (-)-4-phenyltetrahydroisoquinoline in rat anococcygeus muscle.
European journal of pharmacology 1993;243(2):155-61.
1993: M Tateyama; Taku Nagao; S Ohta; Masaaki Hirobe; Hiraku Ono
4-Phenyltetrahydroisoquinoline, but not nomifensine or cocaine, inhibits methamphetamine-induced dopamine release.
European journal of pharmacology 1993;240(1):51-6.
1993: M Tateyama; S Ohta; Taku Nagao; Masaaki Hirobe; Hiraku Ono
Inhibitory effect of 4-phenyltetrahydroisoquinoline on locomotion and dopamine release induced by micro-injection of methamphetamine into the nucleus accumbens of the rat.
Neuropharmacology 1993;32(8):761-6.
1993: K Kikuchi; Tetsuo Nagano; Hiroshi Hayakawa; Yasunobu Hirata; Masaaki Hirobe
Detection of nitric oxide production from a perfused organ by a luminol-H2O2 system.
Analytical chemistry 1993;65(13):1794-9.
1993: H Nakagawa; Y Makino; Y Yoshida; S Ohta; Masaaki Hirobe
A novel metabolite of 3,4-methylenedioxyamphetamine (MDA): formation of 3-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline and its pharmacological effect.
Biological & pharmaceutical bulletin 1993;16(6):579-82.
1993: Hiroshi Hayakawa; Yasunobu Hirata; Etsu Suzuki; T Sugimoto; H Matsuoka; K Kikuchi; Tetsuo Nagano; Masaaki Hirobe; T Sugimoto
Mechanisms for altered endothelium-dependent vasorelaxation in isolated kidneys from experimental hypertensive rats.
The American journal of physiology 1993;264(5 Pt 2):H1535-41.
1993: Y Urano; T Higuchi; Masaaki Hirobe
Unusual substituent effects in the hydroxylation of phenols by a Cu(2+)-ascorbic acid-O2 system, gamma-radiolysis, and microsomes.
Biochemical and biophysical research communications 1993;192(2):568-74.
1993: Takeshi Doi; T Mori; T Mashino; Masaaki Hirobe
Application of chemical cytochrome P-450 model systems to studies on drug metabolism. VI. N,N-coupling reaction of N-methylaniline catalyzed by polypeptide-bound porphyrinatoiron(III) and cytochrome P-450.
Biochemical and biophysical research communications 1993;191(2):737-43.
1993: M Tateyama; S Ohta; Taku Nagao; Masaaki Hirobe; Hiraku Ono
Effect of 4-phenyl-1,2,3,4-tetrahydroisoquinoline on ambulation induced by injection of methamphetamine into the nucleus accumbens in rats.
Neuropharmacology 1993;32(3):243-8.
1993: R Akasaka; T Mashino; Masaaki Hirobe
Cytochrome P450-like substrate oxidation catalyzed by cytochrome c and immobilized cytochrome c.
Archives of biochemistry and biophysics 1993;301(2):355-60.
1993: Y Tasaki; Y Makino; S Ohta; Masaaki Hirobe
Biosynthesis of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), a possible antiparkinsonism agent.
Advances in neurology 1993;60():231-3.
1992: H Ohi; E Takahara; S Ohta; Masaaki Hirobe
Effects of oxygen concentration on the metabolism of anisole homologues by rat liver microsomes.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(11):1329-37.
1992: M Satoh; S Ohta; Taku Nagao; Masaaki Hirobe; H Fukuda; Hiraku Ono
Amphetamine-antagonistic property of 4-phenyltetrahydroisoquinoline: effect on noradrenaline release in spinal cord slices.
Japanese journal of pharmacology 1992;60(2):121-5.
1992: K Kikuchi; H Hayakawa; Tetsuo Nagano; Y Hirata; T Sugimoto; Masaaki Hirobe
New method of detecting nitric oxide production.
Chemical & pharmaceutical bulletin 1992;40(8):2233-5.
1992: A Mitsumoto; Tetsuo Nagano; Masaaki Hirobe
Toxicity of 1-methyl-4-phenylpyridinium derivatives in Escherichia coli.
Archives of biochemistry and biophysics 1992;296(2):482-8.
1991: Y Tasaki; Y Makino; S Ohta; Masaaki Hirobe
1-Methyl-1,2,3,4-tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse, prevents parkinsonism-like behavior abnormalities.
Journal of neurochemistry 1991;57(6):1940-3.
1991: Hiraku Ono; Y Hasebe; M Satoh; Taku Nagao; S Ohta; Masaaki Hirobe; H Fuduka
Amphetamine-antagonistic properties of 4-phenyl-1,2,3,4- tetrahydroisoquinoline: inhibition of spinal reflex-enhancing effects of methamphetamine, phenylethylamine and nomifensine.
Brain research 1991;564(2):319-22.
1991: H Masumoto; S Ohta; Masaaki Hirobe
Application of chemical cytochrome P-450 model systems to studies on drug metabolism. IV. Mechanism of piperidine metabolism pathways via an iminium intermediate.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(4):768-80.
1991: K Kikuchi; Y Nagatsu; Y Makino; T Mashino; S Ohta; Masaaki Hirobe
Metabolism and penetration through blood-brain barrier of parkinsonism-related compounds. 1,2,3,4-Tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(1):257-62.
1991: Tetsuo Nagano; Tetsuya Hirano; Masaaki Hirobe
Novel iron complexes behave like superoxide dismutase in vivo.
Free radical research communications 1991;12-13 Pt 1():221-7.
1990: Y Makino; S Ohta; Y Tasaki; O Tachikawa; M Kashiwasake; Masaaki Hirobe
A novel and neurotoxic tetrahydroisoquinoline derivative in vivo: formation of 1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline, a condensation product of amphetamines, in brains of rats under chronic ethanol treatment.
Journal of neurochemistry 1990;55(3):963-9.
1990: Y Makino; Y Tasaki; S Ohta; Masaaki Hirobe
Confirmation of the enantiomers of 1-methyl-1,2,3,4-tetrahydroisoquinoline in the mouse brain and foods applying gas chromatography/mass spectrometry with negative ion chemical ionization.
Biomedical & environmental mass spectrometry 1990;19(7):415-9.
1990: K Aihara; T Higuchi; Masaaki Hirobe
3-Hydroxycoumarins: first direct preparation from coumarins using a Cu2(+)-ascorbic acid-O2 system, and their potent bioactivities.
Biochemical and biophysical research communications 1990;168(1):169-75.
1990: K Aihara; T Higuchi; Masaaki Hirobe
Increasing 5-lipoxygenase inhibitory activities by oxidative conversion of o-methoxyphenols to catechols using a Cu2(+)-ascorbic acid-O2 system.
Chemical & pharmaceutical bulletin 1990;38(3):842-4.
1990: Y Nagatsu; T Higuchi; Masaaki Hirobe
Application of chemical P-450 model systems to study drug metabolism. III. Metabolism of 3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine.
Chemical & pharmaceutical bulletin 1990;38(2):400-3.
1990: S Ohta; O Tachikawa; Y Makino; Y Tasaki; Masaaki Hirobe
Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer.
Life sciences 1990;46(8):599-605.
1989: Hiraku Ono; Y Hasebe; T Mori; H Fukuda; M Kohno; S Ohta; Masaaki Hirobe
Structure-activity relationships of phenylethylamine analogs in their serotonergic depressant effects on the spinal monosynaptic reflex in rats.
Journal of pharmacobio-dynamics 1989;12(7):384-91.
1989: Tetsuo Nagano; Tetsuya Hirano; Masaaki Hirobe
Superoxide dismutase mimics based on iron in vivo.
The Journal of biological chemistry 1989;264(16):9243-9.
1989: Y Hasebe; Hiraku Ono; H Fukuda; S Ohta; Masaaki Hirobe
Enhancement of spinal monosynaptic reflexes with phenylethylamine and related drugs through descending noradrenergic neurons.
Journal of pharmacobio-dynamics 1989;12(4):241-5.
1989: Y Hasebe; Hiraku Ono; H Fukuda; S Ohta; Masaaki Hirobe
The most desirable conformation of phenylethylamine (PEA) moiety stimulating noradrenergic neurons: effects of PEA, methamphetamine, phenelzine, methylphenidate, nomifensine and mazindol on rat spinal reflexes.
General pharmacology 1989;20(3):375-9.
1989: Katsuo Koike; I Takayanagi; S Wani; T Yanagita; S Ohta; Masaaki Hirobe
Effect of tetrahydroisoquinoline (TIQ), one of endogenous substances inducing parkinsonism, on isolated rat vas deferens.
General pharmacology 1989;20(2):259-60.
1989: T Toru; F Konno; I Takayanagi; Masaaki Hirobe
Kappa-receptor mechanisms in synaptosomal Ca uptake.
General pharmacology 1989;20(2):249-52.
1989: M Takahashi; Tetsuo Nagano; Masaaki Hirobe
Dioxathiadiaza-heteropentalenes mediate superoxide and hydrogen peroxide production in Escherichia coli.
Archives of biochemistry and biophysics 1989;268(1):137-43.
1988: H Yamamoto; Tetsuo Nagano; Masaaki Hirobe
Carbon tetrachloride toxicity on Escherichia coli exacerbated by superoxide.
The Journal of biological chemistry 1988;263(25):12224-7.
1988: Y Makino; S Ohta; O Tachikawa; Masaaki Hirobe
Presence of tetrahydroisoquinoline and 1-methyl-tetrahydro-isoquinoline in foods: compounds related to Parkinson's disease.
Life sciences 1988;43(4):373-8.
1987: T Tominaga; O Inoue; K Suzuki; T Yamasaki; Masaaki Hirobe
[13N]-beta-phenethylamine ([13N]PEA): a prototype tracer for measurement of MAO-B activity in heart.
Biochemical pharmacology 1987;36(21):3671-5.
1987: S Ohta; H Masumoto; K Takeuchi; Masaaki Hirobe
A phenolic metabolite of phencyclidine: the formation of a pharmacologically active metabolite by rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(4):583-4.
1987: T Tominaga; O Inoue; K Suzuki; T Yamasaki; Masaaki Hirobe
Evaluation of 13N-amines as tracers.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1987;14(5):485-90.
1987: T Tominaga; O Inoue; K Suzuki; T Yamasaki; Masaaki Hirobe
Organ distribution and metabolism of [13N]nicotinamide in mice.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1987;14(5):491-6.