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Tomohisa Hirobe

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Tomohisa Hirobe; Kiyomi Eguchi-Kasai; Kimihiko Sugaya; Masahiro Murakami
Effects of low-dose heavy ions on embryonic development in mice and on melanocyte differentiation in the epidermis and hair bulb.
Tomohisa Hirobe; Emi Terunuma
Reduced proliferative and differentiative activity of mouse pink-eyed dilution melanoblasts is related to apoptosis.
Tomohisa Hirobe; Kazumasa Wakamatsu; Shosuke Ito
A new mutation of mouse ruby-eye 2, ru2(d)/Hps5(ru2-d) inhibits eumelanin synthesis but stimulates pheomelanin synthesis in melanocytes.

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All Publications

2013: Tomohisa Hirobe; Kiyomi Eguchi-Kasai; Kimihiko Sugaya; Masahiro Murakami
Effects of low-dose heavy ions on embryonic development in mice and on melanocyte differentiation in the epidermis and hair bulb.
Journal of radiation research 2013;54(3):409-18.
2012: Tomohisa Hirobe; Emi Terunuma
Reduced proliferative and differentiative activity of mouse pink-eyed dilution melanoblasts is related to apoptosis.
Zoological science 2012;29(11):725-32.
2012: Tomohisa Hirobe; Kazumasa Wakamatsu; Shosuke Ito
A new mutation of mouse ruby-eye 2, ru2(d)/Hps5(ru2-d) inhibits eumelanin synthesis but stimulates pheomelanin synthesis in melanocytes.
Zoological science 2012;29(10):652-61.
2011: Tomohisa Hirobe; Shosuke Ito; Yoko Kawa; Sakae Takeuchi; Kazumasa Wakamatsu; Chihiro Yoshihara; Hiroyuki Abe; Yoshinao Soma
A novel deletion mutation of mouse ruby-eye 2 named ru2(d)/Hps5(ru2-d) inhibits melanocyte differentiation and its impaired differentiation is rescued by L-tyrosine.
Zoological science 2011;28(11):790-801.
2011: Tomohisa Hirobe; Kiyomi Eguchi-Kasai; Kimihiko Sugaya; Masahiro Murakami
Effects of low-dose γ-rays on the embryonic development of mouse melanoblasts and melanocytes in the epidermis and hair bulbs.
Zoological science 2011;28(6):389-96.
2011: Tomohisa Hirobe
How are proliferation and differentiation of melanocytes regulated?
Pigment cell & melanoma research 2011;24(3):462-78.
2011: Tomohisa Hirobe; Shosuke Ito; Kazumasa Wakamatsu
The mouse pink-eyed dilution allele of the P-gene greatly inhibits eumelanin but not pheomelanin synthesis.
Pigment cell & melanoma research 2011;24(1):241-6.
2011: Tomohisa Hirobe
Stimulation of the proliferation and differentiation of skin cells by ferrous ferric chloride from a distance.
Biological & pharmaceutical bulletin 2011;34(7):987-95.
2010: Tomohisa Hirobe; Megumi Kiuchi; Kazumasa Wakamatsu; Shosuke Ito
Estrogen increases hair pigmentation in female recessive yellow mice.
Zoological science 2010;27(6):470-6.
2010: Tomohisa Hirobe; Tsuneo Shinpo; Kazuhiko Higuchi; Tomohiko Sano
Life cycle of human melanocytes is regulated by endothelin-1 and stem cell factor in synergy with cyclic AMP and basic fibroblast growth factor.
Journal of dermatological science 2010;57(2):123-31.
2009: Tomohisa Hirobe
Ferrous ferric chloride stimulates the skin cell function and hair growth in mice.
Biological & pharmaceutical bulletin 2009;32(8):1347-53.
2008: Tomohisa Hirobe; Kenji Ishizuka; Shigeru Ogawa; Hiroyuki Abe
Mitochondria are more numerous and smaller in pink-eyed dilution melanoblasts and melanocytes than in wild-type melanocytes in the neonatal mouse epidermis.
Zoological science 2008;25(11):1057-65.
2007: Tomohisa Hirobe; Hiroyuki Abe
Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty mice.
Anatomical record (Hoboken, N.J. : 2007) 2007;290(8):981-93.
2007: Tomohisa Hirobe; Hiyoyuki Abe; Kazumasa Wakamatsu; Shosuke Ito; Yoko Kawa; Yoshinao Soma; Masako Mizoguchi
Excess tyrosine rescues the reduced activity of proliferation and differentiation of cultured recessive yellow melanocytes derived from neonatal mouse epidermis.
European journal of cell biology 2007;86(6):315-30.
2007: Tomohisa Hirobe; Hiroyuki Abe
Excess tyrosine restores the morphology and maturation of melanosomes affected by the murine slaty mutation.
Zoological science 2007;24(4):338-45.
2007: Tomohisa Hirobe; Kazumasa Wakamatsu; Shosuke Ito
Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis.
Zoological science 2007;24(3):209-17.
2007: Tomohisa Hirobe; Kazumasa Wakamatsu; Shosuke Ito
The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male.
Journal of dermatological science 2007;45(1):55-62.
2006: Tomohisa Hirobe; Hiroyuki Abe
The slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytes.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2006;19(5):454-9.
2006: Tomohisa Hirobe; Kazumasa Wakamatsu; Shosuke Ito; Yoko Kawa; Yoshinao Soma; Masako Mizoguchi
The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes.
European journal of cell biology 2006;85(6):537-49.
2005: Tomohisa Hirobe
Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2005;18(1):2-12.
2004: Tomohisa Hirobe; Sakae Takeuchi; Eri Hotta
The melanocortin receptor-1 gene but not the proopiomelanocortin gene is expressed in melanoblasts and contributes their differentiation in the mouse skin.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(6):627-35.
2004: Tomohisa Hirobe; Kiyomi Eguchi-Kasai; Masahiro Murakami
Effects of carbon-ion radiation on the postnatal development of mice and on the yield of white spots in the mid-ventrum and tail tips.
Radiation research 2004;162(5):580-4.
2004: Tomohisa Hirobe; Sakae Takeuchi; Eri Hotta; Kazumasa Wakamatsu; Shosuke Ito
Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(5):506-14.
2004: Tomohisa Hirobe; Rikako Furuya; Ohji Ifuku; Masatake Osawa; Shin-Ichi Nishikawa
Granulocyte-macrophage colony-stimulating factor is a keratinocyte-derived factor involved in regulating the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture.
Experimental cell research 2004;297(2):593-606.
2004: Tomohisa Hirobe; Rikako Furuya; Eijiro Hara; Izumi Horii; Makoto Tsunenaga; Ohji Ifuku
Granulocyte-macrophage colony-stimulating factor (GM-CSF) controls the proliferation and differentiation of mouse epidermal melanocytes from pigmented spots induced by ultraviolet radiation B.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(3):230-40.
2004: Tomohisa Hirobe; Masatake Osawa; Shin-Ichi Nishikawa
Hepatocyte growth factor controls the proliferation of cultured epidermal melanoblasts and melanocytes from newborn mice.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2004;17(1):51-61.
2003: Tomohisa Hirobe; Masatake Osawa; Shin-Ichi Nishikawa
Steel factor controls the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2003;16(6):644-55.
2003: Tomohisa Hirobe; Kazumasa Wakamatsu; Shosuke Ito
Changes in the proliferation and differentiation of neonatal mouse pink-eyed dilution melanocytes in the presence of excess tyrosine.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2003;16(6):619-28.
2002: Tomohisa Hirobe; Rikako Furuya; Satoru Akiu; Ohji Ifuku; Minoru Fukuda
Keratinocytes control the proliferation and differentiation of cultured epidermal melanocytes from ultraviolet radiation B-induced pigmented spots in the dorsal skin of hairless mice.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2002;15(5):391-9.
2002: Rikako Furuya; Satoru Akiu; Ritsuro Ideta; Masako Naganuma; Minoru Fukuda; Tomohisa Hirobe
Changes in the proliferative activity of epidermal melanocytes in serum-free primary culture during the development of ultraviolet radiation B-induced pigmented spots in hairless mice.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2002;15(5):348-56.
2002: Tomohisa Hirobe
Role of leukemia inhibitory factor in the regulation of the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture.
Journal of cellular physiology 2002;192(3):315-26.
2002: Tomohisa Hirobe; Kazumasa Wakamatsu; Shosuke Ito; Hiroyuki Abe; Yoko Kawa; Masako Mizoguchi
Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture.
Journal of cellular physiology 2002;191(2):162-72.
2002: Tomohisa Hirobe; Yoko Kawa; Masako Mizoguchi; Shosuke Ito; Kazumasa Wakamatsu
Effects of genic substitution at the pink-eyed dilution locus on the proliferation and differentiation of mouse epidermal melanocytes in vivo and in vitro.
The Journal of experimental zoology 2002;292(4):351-66.
2001: Tomohisa Hirobe
Endothelins are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in serum-free primary culture.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2001;6(1):25-31.
2000: Tomohisa Hirobe; Hiroyuki Abe
ACTH(4-12) is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture.
The Journal of experimental zoology 2000;286(6):632-40.
1999: Tomohisa Hirobe; Hiroyuki Abe
Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1999;12(3):147-63.
1998: Rikako Furuya; Satoru Akiu; Masako Naganuma; Minoru Fukuda; Tomohisa Hirobe
The proliferation and differentiation of neonatal epidermal melanocytes in F1 hairless mice of HR-1 x HR/De in serum-free culture.
The Journal of dermatology 1998;25(4):211-21.
1998: Yasuko Hyodo-Taguchi; Shinji Fushiki; C Kinoshita; Yuji Ishikawa; Tomohisa Hirobe
Effects of low-dose X-irradiation on the development of the mouse cerebellar cortex.
Journal of radiation research 1998;39(1):11-9.
1998: Tomohisa Hirobe; Kazumasa Wakamatsu; Shosuke Ito
Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture.
European journal of cell biology 1998;75(2):184-91.
1997: Yasuko Hyodo-Taguchi; Shinji Fushiki; C Kinoshita; Yuji Ishikawa; Tomohisa Hirobe
Effects of continuous low-dose prenatal irradiation on neuronal migration in mouse cerebral cortex.
Journal of radiation research 1997;38(2):87-94.
1997: S Fushiki; Yasuko Hyodo-Taguchi; C Kinoshita; Y Ishikawa; Tomohisa Hirobe
Short- and long-term effects of low-dose prenatal X-irradiation in mouse cerebral cortex, with special reference to neuronal migration.
Acta neuropathologica 1997;93(5):443-9.
1996: Tomohisa Hirobe
Hydrocortisone is involved in regulating the proliferation and differentiation of mouse epidermal melanoblasts in serum-free culture in the presence of keratinocytes.
European journal of cell biology 1996;71(4):387-94.
1995: Tomohisa Hirobe
Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle.
Histology and histopathology 1995;10(1):223-37.
1994: Tomohisa Hirobe
Effects of gamma-irradiation on the yield of mid-ventral white spots in mice in different genetic backgrounds and at different times during development.
Mutation research 1994;322(3):213-20.
1994: Tomohisa Hirobe
Effects of activators (SC-9 and OAG) and inhibitors (staurosporine and H-7) of protein kinase C on the proliferation of mouse epidermal melanoblasts in serum-free culture.
Journal of cell science 1994;107 ( Pt 6)():1679-86.
1994: Tomohisa Hirobe
Keratinocytes are involved in regulating the developmental changes in the proliferative activity of mouse epidermal melanoblasts in serum-free culture.
Developmental biology 1994;161(1):59-69.
1992: Tomohisa Hirobe
Melanocyte stimulating hormone induces the differentiation of mouse epidermal melanocytes in serum-free culture.
Journal of cellular physiology 1992;152(2):337-45.
1992: Tomohisa Hirobe
Control of melanocyte proliferation and differentiation in the mouse epidermis.
Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 1992;5(1):1-11.
1992: Tomohisa Hirobe
Basic fibroblast growth factor stimulates the sustained proliferation of mouse epidermal melanoblasts in a serum-free medium in the presence of dibutyryl cyclic AMP and keratinocytes.
Development (Cambridge, England) 1992;114(2):435-45.
1991: Tomohisa Hirobe
Developmental interactions in the pigmentary system of the tip of the mouse tail: effects of coat-color genes on the expression of a tail-spotting gene.
The Journal of experimental zoology 1991;258(3):353-8.
1991: Tomohisa Hirobe
Selective growth and serial passage of mouse melanocytes from neonatal epidermis in a medium supplemented with bovine pituitary extract.
The Journal of experimental zoology 1991;257(2):184-94.
1990: Tomohisa Hirobe; X Y Zhou
Effects of gamma-radiation on the differentiation of mouse melanocytes in the hair follicles.
Mutation research 1990;234(2):91-6.
1988: Tomohisa Hirobe
Genetic factors controlling the proliferative activity of mouse epidermal melanocytes during the healing of skin wounds.
Genetics 1988;120(2):551-8.
1988: Tomohisa Hirobe
Developmental changes of the proliferative response of mouse epidermal melanocytes to skin wounding.
Development (Cambridge, England) 1988;102(3):567-74.