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Setsuo Hirohashi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Arai Eri; Ushijima Saori; Gotoh Masahiro; Ojima Hidenori; Kosuge Tomoo; Hosoda Fumie; Shibata Tatsuhiro; Kondo Tadashi; Yokoi Sana; Imoto Issei; Inazawa Johji; Hirohashi Setsuo; Kanai Yae
Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma.
Kubo Takashi; Kuroda Yukie; Kokubu Akiko; Hosoda Fumie; Arai Yasuhito; Hiraoka Nobuyoshi; Hirohashi Setsuo; Shibata Tatsuhiro
Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer.
Ono Masaya; Matsubara Junichi; Honda Kazufumi; Sakuma Tomohiro; Hashiguchi Tomoyo; Nose Hiroshi; Nakamori Shoji; Okusaka Takuji; Kosuge Tomoo; Sata Naohiro; Nagai Hideo; Ioka Tatsuya; Tanaka Sachiko; Tsuchida Akihiko; Aoki Tatsuya; Shimahara Masashi; Yasunami Yohichi; Itoi Takao; Moriyasu Fuminori; Negishi Ayako; Kuwabara Hideya; Shoji Ayako; Hirohashi Setsuo; Yamada Tesshi
Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics.

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All Publications

2009: Arai Eri; Ushijima Saori; Gotoh Masahiro; Ojima Hidenori; Kosuge Tomoo; Hosoda Fumie; Shibata Tatsuhiro; Kondo Tadashi; Yokoi Sana; Imoto Issei; Inazawa Johji; Hirohashi Setsuo; Kanai Yae
Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma.
International journal of cancer. Journal international du cancer 2009;125(12):2854-62.
2009: Kubo Takashi; Kuroda Yukie; Kokubu Akiko; Hosoda Fumie; Arai Yasuhito; Hiraoka Nobuyoshi; Hirohashi Setsuo; Shibata Tatsuhiro
Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer.
Pancreas 2009;38(7):e200-6.
2009: Ono Masaya; Matsubara Junichi; Honda Kazufumi; Sakuma Tomohiro; Hashiguchi Tomoyo; Nose Hiroshi; Nakamori Shoji; Okusaka Takuji; Kosuge Tomoo; Sata Naohiro; Nagai Hideo; Ioka Tatsuya; Tanaka Sachiko; Tsuchida Akihiko; Aoki Tatsuya; Shimahara Masashi; Yasunami Yohichi; Itoi Takao; Moriyasu Fuminori; Negishi Ayako; Kuwabara Hideya; Shoji Ayako; Hirohashi Setsuo; Yamada Tesshi
Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics.
The Journal of biological chemistry 2009;284(42):29041-9.
2009: Nakamura Yu; Migita Toshiro; Hosoda Fumie; Okada Naoko; Gotoh Masahiro; Arai Yasuhito; Fukushima Michiyo; Ohki Misao; Miyata Satoshi; Takeuchi Kengo; Imoto Issei; Katai Hitoshi; Yamaguchi Toshiharu; Inazawa Johji; Hirohashi Setsuo; Ishikawa Yuichi; Shibata Tatsuhiro
Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression.
International journal of cancer. Journal international du cancer 2009;125(8):1859-67.
2009: Shibata Tatsuhiro; Kokubu Akiko; Tsuta Koji; Hirohashi Setsuo
Oncogenic mutation of PIK3CA in small cell lung carcinoma: a potential therapeutic target pathway for chemotherapy-resistant lung cancer.
Cancer letters 2009;283(2):203-11.
2009: Shomori Kohei; Ochiai Atsushi; Akimoto Shingo; Ino Yoshinori; Shudo Koyo; Ito Hisao; Hirohashi Setsuo
Tyrosine-phosphorylation of the 12th armadillo-repeat of beta-catenin is associated with cadherin dysfunction in human cancer.
International journal of oncology 2009;35(3):517-24.
2009: Uemura Norihisa; Nakanishi Yukihiro; Kato Hoichi; Nagino Masato; Hirohashi Setsuo; Kondo Tadashi
Antibody-based proteomics for esophageal cancer: Identification of proteins in the nuclear factor-kappaB pathway and mitotic checkpoint.
Cancer science 2009;100(9):1612-22.
2009: Negishi Ayako; Masuda Mari; Ono Masaya; Honda Kazufumi; Shitashige Miki; Satow Reiko; Sakuma Tomohiro; Kuwabara Hideya; Nakanishi Yukihiro; Kanai Yae; Omura Ken; Hirohashi Setsuo; Yamada Tesshi
Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma.
Cancer science 2009;100(9):1605-11.
2009: Akishima-Fukasawa Yuri; Nakanishi Yukihiro; Ino Yoshinori; Moriya Yoshihiro; Kanai Yae; Hirohashi Setsuo
Prognostic significance of CXCL12 expression in patients with colorectal carcinoma.
American journal of clinical pathology 2009;132(2):202-10; quiz 307.
2009: Matsubara Junichi; Ono Masaya; Negishi Ayako; Ueno Hideki; Okusaka Takuji; Furuse Junji; Furuta Koh; Sugiyama Emiko; Saito Yoshiro; Kaniwa Nahoko; Sawada Junichi; Honda Kazufumi; Sakuma Tomohiro; Chiba Tsutomu; Saijo Nagahiro; Hirohashi Setsuo; Yamada Tesshi
Identification of a predictive biomarker for hematologic toxicities of gemcitabine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(13):2261-8.
2009: Uemura Norihisa; Nakanishi Yukihiro; Kato Hoichi; Saito Shigeru; Nagino Masato; Hirohashi Setsuo; Kondo Tadashi
Transglutaminase 3 as a prognostic biomarker in esophageal cancer revealed by proteomics.
International journal of cancer. Journal international du cancer 2009;124(9):2106-15.
2009: Kikuta Kazutaka; Tochigi Naobumi; Shimoda Tadakazu; Yabe Hiroki; Morioka Hideo; Toyama Yoshiaki; Hosono Ako; Beppu Yasuo; Kawai Akira; Hirohashi Setsuo; Kondo Tadashi
Nucleophosmin as a candidate prognostic biomarker of Ewing's sarcoma revealed by proteomics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2885-94.
2009: Yoshikawa D; Ojima H; Kokubu A; Ochiya T; Kasai S; Hirohashi S; Shibata T
Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma.
British journal of cancer 2009;100(8):1257-66.
2009: Yamazaki Ken; Takamura Masaaki; Masugi Yohei; Mori Taisuke; Du Wenlin; Hibi Taizo; Hiraoka Nobuyoshi; Ohta Tsutomu; Ohki Misao; Hirohashi Setsuo; Sakamoto Michiie
Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility.
Laboratory investigation; a journal of technical methods and pathology 2009;89(4):425-32.
2009: Negishi Ayako; Ono Masaya; Handa Yasushi; Kato Hidenori; Yamashita Kohki; Honda Kazufumi; Shitashige Miki; Satow Reiko; Sakuma Tomohiro; Kuwabara Hideya; Omura Ken; Hirohashi Setsuo; Yamada Tesshi
Large-scale quantitative clinical proteomics by label-free liquid chromatography and mass spectrometry.
Cancer science 2009;100(3):514-9.
2009: Arai Eri; Ushijima Saori; Fujimoto Hiroyuki; Hosoda Fumie; Shibata Tatsuhiro; Kondo Tadashi; Yokoi Sana; Imoto Issei; Inazawa Johji; Hirohashi Setsuo; Kanai Yae
Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome.
Carcinogenesis 2009;30(2):214-21.
2009: Ojima Hidenori; Kanai Yae; Iwasaki Motoki; Hiraoka Nobuyoshi; Shimada Kazuaki; Sano Tsuyoshi; Sakamoto Yoshihiro; Esaki Minoru; Kosuge Tomoo; Sakamoto Michiie; Hirohashi Setsuo
Intraductal carcinoma component as a favorable prognostic factor in biliary tract carcinoma.
Cancer science 2009;100(1):62-70.
2009: Kondo Tadashi; Hirohashi Setsuo
Application of 2D-DIGE in cancer proteomics toward personalized medicine.
Methods in molecular biology (Clifton, N.J.) 2009;577():135-54.
2009: Yamanashi Takahiro; Nakanishi Yukihiro; Fujii Gen; Akishima-Fukasawa Yuri; Moriya Yoshihiro; Kanai Yae; Watanabe Masahiko; Hirohashi Setsuo
Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma.
Oncology 2009;77(1):53-62.
2008: Orimo Tatsuya; Ojima Hidenori; Hiraoka Nobuyoshi; Saito Shigeru; Kosuge Tomoo; Kakisaka Tatsuhiko; Yokoo Hideki; Nakanishi Kazuaki; Kamiyama Toshiya; Todo Satoru; Hirohashi Setsuo; Kondo Tadashi
Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2008;48(6):1851-63.
2008: Shibata Tatsuhiro; Kokubu Akiko; Gotoh Masahiro; Ojima Hidenori; Ohta Tsutomu; Yamamoto Masayuki; Hirohashi Setsuo
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer.
Gastroenterology 2008;135(4):1358-1368, 1368.e1-4.
2008: Arai Eri; Ushijima Saori; Tsuda Hitoshi; Fujimoto Hiroyuki; Hosoda Fumie; Shibata Tatsuhiro; Kondo Tadashi; Imoto Issei; Inazawa Johji; Hirohashi Setsuo; Kanai Yae
Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5531-9.
2008: Kikuchi Satoru; Honda Kazufumi; Tsuda Hitoshi; Hiraoka Nobuyoshi; Imoto Issei; Kosuge Tomoo; Umaki Tomoko; Onozato Kaoru; Shitashige Miki; Yamaguchi Umio; Ono Masaya; Tsuchida Akihiko; Aoki Tatsuya; Inazawa Johji; Hirohashi Setsuo; Yamada Tesshi
Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5348-56.
2008: Shibata Tatsuhiro; Ohta Tsutomu; Tong Kit I; Kokubu Akiko; Odogawa Reiko; Tsuta Koji; Asamura Hisao; Yamamoto Masayuki; Hirohashi Setsuo
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13568-73.
2008: Yamaguchi Umio; Nakayama Robert; Honda Kazufumi; Ichikawa Hitoshi; Hasegawa Tadashi; Shitashige Miki; Ono Masaya; Shoji Ayako; Sakuma Tomohiro; Kuwabara Hideya; Shimada Yasuhiro; Sasako Mitsuru; Shimoda Tadakazu; Kawai Akira; Hirohashi Setsuo; Yamada Tesshi
Distinct gene expression-defined classes of gastrointestinal stromal tumor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(25):4100-8.
2008: Hanada S; Maeshima A; Matsuno Y; Ohta T; Ohki M; Yoshida T; Hayashi Y; Yoshizawa Y; Hirohashi S; Sakamoto M
Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression.
The Journal of pathology 2008;216(1):75-82.
2008: Kawai Akira; Kondo Tadashi; Suehara Yoshiyuki; Kikuta Kazutaka; Hirohashi Setsuo
Global protein-expression analysis of bone and soft tissue sarcomas.
Clinical orthopaedics and related research 2008;466(9):2099-106.
2008: Narisawa-Saito Mako; Yoshimatsu Yuki; Ohno Shin-ichi; Yugawa Takashi; Egawa Nagayasu; Fujita Masatoshi; Hirohashi Setsuo; Kiyono Tohru
An in vitro multistep carcinogenesis model for human cervical cancer.
Cancer research 2008;68(14):5699-705.
2008: Kikuchi Ryoko; Tsuda Hitoshi; Kozaki Ken-ichi; Kanai Yae; Kasamatsu Takahiro; Sengoku Kazuo; Hirohashi Setsuo; Inazawa Johji; Imoto Issei
Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer.
Cancer research 2008;68(13):5067-75.
2008: Shitashige Miki; Satow Reiko; Honda Kazufumi; Ono Masaya; Hirohashi Setsuo; Yamada Tesshi
Regulation of Wnt signaling by the nuclear pore complex.
Gastroenterology 2008;134(7):1961-71, 1971.e1-4.
2008: Suzuki Ayako; Shibata Tatsuhiro; Shimada Yutaka; Murakami Yoshinori; Horii Akira; Shiratori Keiko; Hirohashi Setsuo; Inazawa Johji; Imoto Issei
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer science 2008;99(5):986-94.
2008: Shitashige Miki; Hirohashi Setsuo; Yamada Tesshi
Wnt signaling inside the nucleus.
Cancer science 2008;99(4):631-7.
2008: Suehara Yoshiyuki; Kondo Tadashi; Seki Kunihiko; Shibata Tatsuhiro; Fujii Kiyonaga; Gotoh Masahiro; Hasegawa Tadashi; Shimada Yasuhiro; Sasako Mitsuru; Shimoda Tadakazu; Kurosawa Hisashi; Beppu Yasuo; Kawai Akira; Hirohashi Setsuo
Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(6):1707-17.
2008: Ohta Tsutomu; Iijima Kumiko; Miyamoto Mamiko; Nakahara Izumi; Tanaka Hiroshi; Ohtsuji Makiko; Suzuki Takafumi; Kobayashi Akira; Yokota Jun; Sakiyama Tokuki; Shibata Tatsuhiro; Yamamoto Masayuki; Hirohashi Setsuo
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.
Cancer research 2008;68(5):1303-9.
2008: Sai Kimie; Saito Yoshiro; Sakamoto Hiromi; Shirao Kuniaki; Kurose Koichi; Saeki Mayumi; Ozawa Shogo; Kaniwa Nahoko; Hirohashi Setsuo; Saijo Nagahiro; Sawada Jun-ichi; Yoshida Teruhiko
Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients.
Cancer letters 2008;261(2):165-71.
2008: Yoshikawa D; Ojima H; Iwasaki M; Hiraoka N; Kosuge T; Kasai S; Hirohashi S; Shibata T
Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma.
British journal of cancer 2008;98(2):418-25.
2008: Ochiai Hiroki; Nakanishi Yukihiro; Fukasawa Yuri; Sato Yasunori; Yoshimura Kimio; Moriya Yoshihiro; Kanai Yae; Watanabe Masahiko; Hasegawa Hirotoshi; Kitagawa Yuko; Kitajima Masaki; Hirohashi Setsuo
A new formula for predicting liver metastasis in patients with colorectal cancer: immunohistochemical analysis of a large series of 439 surgically resected cases.
Oncology 2008;75(1-2):32-41.
2008: Batistatou Anna; Charalabopoulos Konstantinos; Nakanishi Yukihiro; Vagianos Constantine; Hirohashi Setsuo; Agnantis Niki J; Scopa Chrissoula D
Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin.
Endocrine pathology 2008;19(3):197-202.
2007: Yoshida Yukihiro; Kokubu Akiko; Suzuki Kenji; Kuribayashi Hidehiko; Tsuta Koji; Matsuno Yoshihiro; Kusumoto Masahiko; Kanai Yae; Asamura Hisao; Hirohashi Setsuo; Shibata Tatsuhiro
Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity.
Japanese journal of clinical oncology 2007;37(12):907-12.
2007: Shitashige Miki; Satow Reiko; Honda Kazufumi; Ono Masaya; Hirohashi Setsuo; Yamada Tesshi
Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.
Cancer science 2007;98(12):1862-7.
2007: Kanai Yae; Hirohashi Setsuo
Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state.
Carcinogenesis 2007;28(12):2434-42.
2007: Huang Lin; Shitashige Miki; Satow Reiko; Honda Kazufumi; Ono Masaya; Yun Jisoo; Tomida Akihiro; Tsuruo Takashi; Hirohashi Setsuo; Yamada Tesshi
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
Gastroenterology 2007;133(5):1569-78.
2007: Katoh Hiroto; Ojima Hidenori; Kokubu Akiko; Saito Shigeru; Kondo Tadashi; Kosuge Tomoo; Hosoda Fumie; Imoto Issei; Inazawa Johji; Hirohashi Setsuo; Shibata Tatsuhiro
Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.
Gastroenterology 2007;133(5):1475-86.
2007: Nam Jeong-Seok; Hirohashi Setsuo; Wakefield Lalage M
Dysadherin: a new player in cancer progression.
Cancer letters 2007;255(2):161-9.
2007: Kikuchi Ryoko; Tsuda Hitoshi; Kanai Yae; Kasamatsu Takahiro; Sengoku Kazuo; Hirohashi Setsuo; Inazawa Johji; Imoto Issei
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Cancer research 2007;67(15):7095-105.
2007: Shibata Tatsuhiro; Hanada Satoko; Kokubu Akiko; Matsuno Yoshihiro; Asamura Hisao; Ohta Tsutomu; Sakamoto Michiie; Hirohashi Setsuo
Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma.
Cancer science 2007;98(7):985-91.
2007: Kikuchi Satoru; Honda Kazufumi; Handa Yasushi; Kato Hidenori; Yamashita Kohki; Umaki Tomoko; Shitashige Miki; Ono Masaya; Tsuchida Akihiko; Aoki Tatsuya; Hirohashi Setsuo; Yamada Tesshi
Serum albumin-associated peptides of patients with uterine endometrial cancer.
Cancer science 2007;98(6):822-9.
2007: Kakisaka Tatsuhiko; Kondo Tadashi; Okano Tetsuya; Fujii Kiyonaga; Honda Kazufumi; Endo Mitsufumi; Tsuchida Akihiko; Aoki Tatsuya; Itoi Takao; Moriyasu Fuminori; Yamada Tesshi; Kato Harubumi; Nishimura Toshihide; Todo Satoru; Hirohashi Setsuo
Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;852(1-2):257-67.
2007: Sawada Morio; Kanai Yae; Arai Eri; Ushijima Saori; Ojima Hidenori; Hirohashi Setsuo
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Cancer letters 2007;251(2):211-9.
2007: Batistatou A; Peschos D; Tsanou H; Charalabopoulos A; Nakanishi Y; Hirohashi S; Agnantis N J; Charalabopoulos K
In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin.
British journal of cancer 2007;96(9):1404-8.
2007: Yokoo Hideki; Kondo Tadashi; Okano Tetsuya; Nakanishi Kazuaki; Sakamoto Michiie; Kosuge Tomoo; Todo Satoru; Hirohashi Setsuo
Protein expression associated with early intrahepatic recurrence of hepatocellular carcinoma after curative surgery.
Cancer science 2007;98(5):665-73.
2007: Shitashige Miki; Naishiro Yasuyoshi; Idogawa Masashi; Honda Kazufumi; Ono Masaya; Hirohashi Setsuo; Yamada Tesshi
Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing.
Gastroenterology 2007;132(3):1039-54.
2007: Loukopoulos Panayiotis; Shibata Tatsuhiro; Katoh Hiroto; Kokubu Akiko; Sakamoto Michiie; Yamazaki Ken; Kosuge Tomoo; Kanai Yae; Hosoda Fumie; Imoto Issei; Ohki Misao; Inazawa Jyoji; Hirohashi Setsuo
Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome.
Cancer science 2007;98(3):392-400.
2007: Hara Tomohiko; Honda Kazufumi; Shitashige Miki; Ono Masaya; Matsuyama Hideyasu; Naito Katsusuke; Hirohashi Setsuo; Yamada Tesshi
Mass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells.
Molecular & cellular proteomics : MCP 2007;6(3):479-91.
2007: Kobayashi Noritoshi; Hiraoka Nobuyoshi; Yamagami Wataru; Ojima Hidenori; Kanai Yae; Kosuge Tomoo; Nakajima Atsushi; Hirohashi Setsuo
FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):902-11.
2007: Okano Tetsuya; Kondo Tadashi; Fujii Kiyonaga; Nishimura Toshihide; Takano Toshimi; Ohe Yuichiro; Tsuta Koji; Matsuno Yoshihiro; Gemma Akihiko; Kato Harbumi; Kudoh Shoji; Hirohashi Setsuo
Proteomic signature corresponding to the response to gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor in lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):799-805.
2007: Idogawa Masashi; Masutani Mitsuko; Shitashige Miki; Honda Kazufumi; Tokino Takashi; Shinomura Yasuhisa; Imai Kohzoh; Hirohashi Setsuo; Yamada Tesshi
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
Cancer research 2007;67(3):911-8.
2007: Izumi Teiyu; Oda Yoshinao; Hasegawa Tadashi; Nakanishi Yukihiro; Kawai Akira; Sonobe Hiroshi; Takahira Tomonari; Kobayashi Chikashi; Yamamoto Hidetaka; Tamiya Sadafumi; Hirohashi Setsuo; Iwamoto Yukihide; Tsuneyoshi Masazumi
Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression.
The American journal of surgical pathology 2007;31(1):85-94.
2006: Hatakeyama Hiromitsu; Kondo Tadashi; Fujii Kiyonaga; Nakanishi Yukihiro; Kato Hoichi; Fukuda Satoshi; Hirohashi Setsuo
Protein clusters associated with carcinogenesis, histological differentiation and nodal metastasis in esophageal cancer.
Proteomics 2006;6(23):6300-16.
2006: Katoh Hiroto; Shibata Tatsuhiro; Kokubu Akiko; Ojima Hidenori; Kosuge Tomoo; Kanai Yae; Hirohashi Setsuo
Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report.
Genes, chromosomes & cancer 2006;45(11):1050-7.
2006: Takada H; Imoto I; Tsuda H; Nakanishi Y; Sakakura C; Mitsufuji S; Hirohashi S; Inazawa J
Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis.
Oncogene 2006;25(49):6554-62.
2006: Hiraoka Nobuyoshi; Onozato Kaoru; Kosuge Tomoo; Hirohashi Setsuo
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5423-34.
2006: Shibata Rie; Mori Taisuke; Du Wenlin; Chuma Makoto; Gotoh Masahiro; Shimazu Motohide; Ueda Masakazu; Hirohashi Setsuo; Sakamoto Michiie
Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5363-8.
2006: Fujii Kazuyasu; Kondo Tadashi; Yamada Masayo; Iwatsuki Keiji; Hirohashi Setsuo
Toward a comprehensive quantitative proteome database: protein expression map of lymphoid neoplasms by 2-D DIGE and MS.
Proteomics 2006;6(17):4856-76.
2006: Suehara Yoshiyuki; Kondo Tadashi; Fujii Kiyonaga; Hasegawa Tadashi; Kawai Akira; Seki Kunihiko; Beppu Yasuo; Nishimura Toshihide; Kurosawa Hisashi; Hirohashi Setsuo
Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas.
Proteomics 2006;6(15):4402-9.
2006: Shibata Tatsuhiro; Hirohashi Setsuo
[E-cadherin cell adhesion system in human cancer]
Seikagaku. The Journal of Japanese Biochemical Society 2006;78(7):647-56.
2006: Nam Jeong-Seok; Kang Mi-Jin; Suchar Adam M; Shimamura Takeshi; Kohn Ethan A; Michalowska Aleksandra M; Jordan V Craig; Hirohashi Setsuo; Wakefield Lalage M
Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells.
Cancer research 2006;66(14):7176-84.
2006: Okano Tetsuya; Kondo Tadashi; Kakisaka Tatsuhiko; Fujii Kiyonaga; Yamada Masayo; Kato Harubumi; Nishimura Toshihide; Gemma Akihiko; Kudoh Shoji; Hirohashi Setsuo
Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis.
Proteomics 2006;6(13):3938-48.
2006: Ono Masaya; Shitashige Miki; Honda Kazufumi; Isobe Tomohiro; Kuwabara Hideya; Matsuzuki Hirotaka; Hirohashi Setsuo; Yamada Tesshi
Label-free quantitative proteomics using large peptide data sets generated by nanoflow liquid chromatography and mass spectrometry.
Molecular & cellular proteomics : MCP 2006;5(7):1338-47.
2006: Arai Eri; Kanai Yae; Ushijima Saori; Fujimoto Hiroyuki; Mukai Kiyoshi; Hirohashi Setsuo
Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues.
International journal of cancer. Journal international du cancer 2006;119(2):288-96.
2006: Batistatou Anna; Charalabopoulos Alexander K; Scopa Chrisoula D; Nakanishi Yukihiro; Kappas Angelos; Hirohashi Setsuo; Agnantis Niki J; Charalabopoulos Konstantinos
Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma.
Virchows Archiv : an international journal of pathology 2006;448(6):763-7.
2006: Peng Dun-Fa; Kanai Yae; Sawada Morio; Ushijima Saori; Hiraoka Nobuyoshi; Kitazawa Sohei; Hirohashi Setsuo
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.
Carcinogenesis 2006;27(6):1160-8.
2006: Imoto Issei; Izumi Hiroyuki; Yokoi Sana; Hosoda Hiroshi; Shibata Tatsuhiro; Hosoda Fumie; Ohki Misao; Hirohashi Setsuo; Inazawa Johji
Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers.
Cancer research 2006;66(9):4617-26.
2006: Takahashi Yu; Hiraoka Nobuyoshi; Onozato Kaoru; Shibata Tatsuhiro; Kosuge Tomoo; Nimura Yuji; Kanai Yae; Hirohashi Setsuo
Solid-pseudopapillary neoplasms of the pancreas in men and women: do they differ?
Virchows Archiv : an international journal of pathology 2006;448(5):561-9.
2006: Koide Norimasa; Yamada Taketo; Shibata Rie; Mori Taisuke; Fukuma Mariko; Yamazaki Ken; Aiura Koichi; Shimazu Motohide; Hirohashi Setsuo; Nimura Yuji; Sakamoto Michiie
Establishment of perineural invasion models and analysis of gene expression revealed an invariant chain (CD74) as a possible molecule involved in perineural invasion in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2419-26.
2006: Katoh Hiroto; Shibata Tatsuhiro; Kokubu Akiko; Ojima Hidenori; Fukayama Masashi; Kanai Yae; Hirohashi Setsuo
Epigenetic instability and chromosomal instability in hepatocellular carcinoma.
The American journal of pathology 2006;168(4):1375-84.
2006: Fujii Kazuyasu; Kondo Tadashi; Yokoo Hideki; Okano Tetsuya; Yamada Masayo; Yamada Tesshi; Iwatsuki Keiji; Hirohashi Setsuo
Database of two-dimensional polyacrylamide gel electrophoresis of proteins labeled with CyDye DIGE Fluor saturation dye.
Proteomics 2006;6(5):1640-53.
2006: Kyzas Panayiotis A; Stefanou Dimitrios; Batistatou Anna; Agnantis Niki J; Nakanishi Yukihiro; Hirohashi Setsuo; Charalabopoulos Konstantinos
Dysadherin expression in head and neck squamous cell carcinoma: association with lymphangiogenesis and prognostic significance.
The American journal of surgical pathology 2006;30(2):185-93.
2006: Kondo Tadashi; Hirohashi Setsuo
Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics.
Nature protocols 2006;1(6):2940-56.
2005: Batistatou A; Scopa C D; Ravazoula P; Nakanishi Y; Peschos D; Agnantis N J; Hirohashi S; Charalabopoulos K A
Involvement of dysadherin and E-cadherin in the development of testicular tumours.
British journal of cancer 2005;93(12):1382-7.
2005: Takada Hisashi; Imoto Issei; Tsuda Hitoshi; Nakanishi Yukihiro; Ichikura Takashi; Mochizuki Hidetaka; Mitsufuji Shoji; Hosoda Fumie; Hirohashi Setsuo; Ohki Misao; Inazawa Johji
ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.
Oncogene 2005;24(54):8051-60.
2005: Hayashida Yasuharu; Honda Kazufumi; Osaka Yoshiaki; Hara Tomohiko; Umaki Tomoko; Tsuchida Akihiko; Aoki Tatsuya; Hirohashi Setsuo; Yamada Tesshi
Possible prediction of chemoradiosensitivity of esophageal cancer by serum protein profiling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(22):8042-7.
2005: Honda Kazufumi; Hayashida Yasuharu; Umaki Tomoko; Okusaka Takuji; Kosuge Tomoo; Kikuchi Satoru; Endo Mitsufumi; Tsuchida Akihiko; Aoki Tatsuya; Itoi Takao; Moriyasu Fuminori; Hirohashi Setsuo; Yamada Tesshi
Possible detection of pancreatic cancer by plasma protein profiling.
Cancer research 2005;65(22):10613-22.
2005: Fujii Kazuyasu; Kondo Tadashi; Yokoo Hideki; Yamada Tesshi; Matsuno Yoshihiro; Iwatsuki Keiji; Hirohashi Setsuo
Protein expression pattern distinguishes different lymphoid neoplasms.
Proteomics 2005;5(16):4274-86.
2005: Katoh Hiroto; Shibata Tatsuhiro; Kokubu Akiko; Ojima Hidenori; Loukopoulos Panayiotis; Kanai Yae; Kosuge Tomoo; Fukayama Masashi; Kondo Tadashi; Sakamoto Michiie; Hosoda Fumie; Ohki Misao; Imoto Issei; Inazawa Johji; Hirohashi Setsuo
Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome.
Journal of hepatology 2005;43(5):863-74.
2005: Peng Wei-Xia; Shibata Tatsuhiro; Katoh Hiroto; Kokubu Akiko; Matsuno Yoshihiro; Asamura Hisao; Tsuchiya Ryosuke; Kanai Yae; Hosoda Fumie; Sakiyama Tokuki; Ohki Misao; Imoto Issei; Inazawa Johji; Hirohashi Setsuo
Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung.
Cancer science 2005;96(10):661-7.
2005: Sato Satoshi; Idogawa Masashi; Honda Kazufumi; Fujii Gen; Kawashima Hisashi; Takekuma Kouji; Hoshika Akinori; Hirohashi Setsuo; Yamada Tesshi
beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.
Gastroenterology 2005;129(4):1225-36.
2005: Hayashida Yasuharu; Honda Kazufumi; Idogawa Masashi; Ino Yoshinori; Ono Masaya; Tsuchida Akihiko; Aoki Tatsuya; Hirohashi Setsuo; Yamada Tesshi
E-cadherin regulates the association between beta-catenin and actinin-4.
Cancer research 2005;65(19):8836-45.
2005: Hara Tomohiko; Honda Kazufumi; Ono Masaya; Naito Katsusuke; Hirohashi Setsuo; Yamada Tesshi
Identification of 2 serum biomarkers of renal cell carcinoma by surface enhanced laser desorption/ionization mass spectrometry.
The Journal of urology 2005;174(4 Pt 1):1213-7.
2005: Yoshida Yukihiro; Shibata Tatsuhiro; Kokubu Akiko; Tsuta Koji; Matsuno Yoshihiro; Kanai Yae; Asamura Hisao; Tsuchiya Ryosuke; Hirohashi Setsuo
Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.
Lung cancer (Amsterdam, Netherlands) 2005;50(1):1-8.
2005: Shibata Tatsuhiro; Uryu Satomi; Kokubu Akiko; Hosoda Fumie; Ohki Misao; Sakiyama Tokuki; Matsuno Yoshihiro; Tsuchiya Ryosuke; Kanai Yae; Kondo Tadashi; Imoto Issei; Inazawa Johji; Hirohashi Setsuo
Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6177-85.
2005: Mori Yasuharu; Kondo Tadashi; Yamada Tesshi; Tsuchida Akihiko; Aoki Tetsuya; Hirohashi Setsuo
Two-dimensional electrophoresis database of fluorescence-labeled proteins of colon cancer cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;823(2):82-97.
2005: Peng Dun-Fa; Kanai Yae; Sawada Morio; Ushijima Saori; Hiraoka Nobuyoshi; Kosuge Tomoo; Hirohashi Setsuo
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Cancer science 2005;96(7):403-8.
2005: Seike Masahiro; Kondo Tadashi; Fujii Kazuyasu; Okano Tetsuya; Yamada Tesshi; Matsuno Yoshihiro; Gemma Akihiko; Kudoh Shoji; Hirohashi Setsuo
Proteomic signatures for histological types of lung cancer.
Proteomics 2005;5(11):2939-48.
2005: Chihara Yoshitomo; Sugano Kokichi; Kobayashi Ayumi; Kanai Yae; Yamamoto Hidenobu; Nakazono Masaaki; Fujimoto Hiroyuki; Kakizoe Tadao; Fujimoto Kiyohide; Hirohashi Setsuo; Hirao Yoshihiko
Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene.
Laboratory investigation; a journal of technical methods and pathology 2005;85(7):895-907.
2005: Tsuda Hitoshi; Tani Yoichi; Weisenberger Joel; Kitada Shigehiro; Hasegawa Tadashi; Murata Tetsuya; Tamai Seiichi; Hirohashi Setsuo; Matsubara Osamu; Natori Tsuneo
Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features.
Cancer science 2005;96(6):333-9.
2005: Yanagihara Kazuyoshi; Takigahira Misato; Tanaka Hiromi; Komatsu Teruo; Fukumoto Hisao; Koizumi Fumiaki; Nishio Kazuto; Ochiya Takahiro; Ino Yoshinori; Hirohashi Setsuo
Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer.
Cancer science 2005;96(6):323-32.
2005: Idogawa Masashi; Yamada Tesshi; Honda Kazufumi; Sato Satoshi; Imai Kohzoh; Hirohashi Setsuo
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.
Gastroenterology 2005;128(7):1919-36.
2005: Nakagawa Tohru; Kanai Yae; Ushijima Saori; Kitamura Tadaichi; Kakizoe Tadao; Hirohashi Setsuo
DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis.
The Journal of urology 2005;173(5):1767-71.
2005: Nitori Nobuhiro; Ino Yoshinori; Nakanishi Yukihiro; Yamada Tesshi; Honda Kazufumi; Yanagihara Kazuyoshi; Kosuge Tomoo; Kanai Yae; Kitajima Masaki; Hirohashi Setsuo
Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2531-9.
2005: Nishizawa Aya; Nakanishi Yukihiro; Yoshimura Kimio; Sasajima Yuko; Yamazaki Naoya; Yamamoto Akifumi; Hanada Katsumi; Kanai Yae; Hirohashi Setsuo
Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients.
Cancer 2005;103(8):1693-700.
2005: Fujii Kazuyasu; Kondo Tadashi; Yokoo Hideki; Yamada Tesshi; Iwatsuki Keiji; Hirohashi Setsuo
Proteomic study of human hepatocellular carcinoma using two-dimensional difference gel electrophoresis with saturation cysteine dye.
Proteomics 2005;5(5):1411-22.
2005: Izumi Hiroyuki; Inoue Jun; Yokoi Sana; Hosoda Hiroshi; Shibata Tatsuhiro; Sunamori Makoto; Hirohashi Setsuo; Inazawa Johji; Imoto Issei
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Human molecular genetics 2005;14(8):997-1007.
2005: Naishiro Yasuyoshi; Yamada Tesshi; Idogawa Masashi; Honda Kazufumi; Takada Mizuho; Kondo Tadashi; Imai Kohzoh; Hirohashi Setsuo
Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein.
Oncogene 2005;24(19):3141-53.
2005: Oikawa Takuichi; Ojima Hidenori; Yamasaki Susumu; Takayama Tadatoshi; Hirohashi Setsuo; Sakamoto Michiie
Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules.
Journal of hepatology 2005;42(2):225-9.
2005: Honda Kazufumi; Yamada Tesshi; Hayashida Yasuharu; Idogawa Masashi; Sato Satoshi; Hasegawa Fumio; Ino Yoshinori; Ono Masaya; Hirohashi Setsuo
Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.
Gastroenterology 2005;128(1):51-62.
2005: Nakanishi Kazuaki; Sakamoto Michiie; Yamasaki Susumu; Todo Satoru; Hirohashi Setsuo
Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma.
Cancer 2005;103(2):307-12.
2005: Nakagawa Tohru; Kanai Yae; Ushijima Saori; Kitamura Tadaichi; Kakizoe Tadao; Hirohashi Setsuo
DNA hypomethylation on pericentromeric satellite regions significantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas.
The Journal of urology 2005;173(1):243-6.
2004: Sekine S; Takata T; Shibata T; Mori M; Morishita Y; Noguchi M; Uchida T; Kanai Y; Hirohashi S
Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation.
Histopathology 2004;45(6):573-9.
2004: Nakanishi Yukihiro; Akimoto Shingo; Sato Yasuto; Kanai Yae; Sakamoto Michiie; Hirohashi Setsuo
Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2004;12(4):323-8.
2004: Sekine Shigeki; Shimoda Tadakazu; Nimura Satoshi; Nakanishi Yukihiro; Akasu Takayuki; Katai Hitoshi; Gotoda Takuji; Shibata Tatsuhiro; Sakamoto Michiie; Hirohashi Setsuo
High-grade dysplasia associated with fundic gland polyposis in a familial adenomatous polyposis patient, with special reference to APC mutation profiles.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004;17(11):1421-6.
2004: Kanai Yae; Saito Yoshimasa; Ushijima Saori; Hirohashi Setsuo
Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis.
Journal of cancer research and clinical oncology 2004;130(11):636-44.
2004: Shimamura Takeshi; Yasuda Jun; Ino Yoshinori; Gotoh Masahiro; Tsuchiya Akira; Nakajima Atsushi; Sakamoto Michiie; Kanai Yae; Hirohashi Setsuo
Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells.
Cancer research 2004;64(19):6989-95.
2004: Chuma Makoto; Sakamoto Michiie; Yasuda Jun; Fujii Gen; Nakanishi Kazuaki; Tsuchiya Akira; Ohta Tsutomu; Asaka Masahiro; Hirohashi Setsuo
Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.
Journal of hepatology 2004;41(4):629-36.
2004: Loukopoulos Panayiotis; Kanetaka Kengo; Takamura Masaaki; Shibata Tatsuhiro; Sakamoto Michiie; Hirohashi Setsuo
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Pancreas 2004;29(3):193-203.
2004: Akimoto Shingo; Nakanishi Yukihiro; Sakamoto Michiie; Kanai Yae; Hirohashi Setsuo
Laminin 5 beta3 and gamma2 chains are frequently coexpressed in cancer cells.
Pathology international 2004;54(9):688-92.
2004: Seike Masahiro; Kondo Tadashi; Fujii Kazuyasu; Yamada Tesshi; Gemma Akihiko; Kudoh Shoji; Hirohashi Setsuo
Proteomic signature of human cancer cells.
Proteomics 2004;4(9):2776-88.
2004: Yokoo Hideki; Kondo Tadashi; Fujii Kazuyasu; Yamada Tesshi; Todo Satoru; Hirohashi Setsuo
Proteomic signature corresponding to alpha fetoprotein expression in liver cancer cells.
Hepatology (Baltimore, Md.) 2004;40(3):609-17.
2004: Takamura Masaaki; Ichida Takafumi; Matsuda Yasunobu; Kobayashi Masaaki; Yamagiwa Satoshi; Genda Takuya; Shioji Kazuhiko; Hashimoto Satoru; Nomoto Minoru; Hatakeyama Katsuyoshi; Ajioka Yoichi; Sakamoto Michiie; Hirohashi Setsuo; Aoyagi Yutaka
Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.
Cancer letters 2004;212(2):253-9.
2004: Takagi Yasumitsu; Nomizu Motoyoshi; Ui-Tei Kumiko; Tokushige Naoko; Hirohashi Setsuo
Active sites in the carboxyl-terminal region of the laminin alpha chain in Drosophila neuronal cell spreading.
Archives of insect biochemistry and physiology 2004;56(4):162-9.
2004: Yanagihara Kazuyoshi; Tanaka Hiromi; Takigahira Misato; Ino Yoshinori; Yamaguchi Yoshiyuki; Toge Tetsuya; Sugano Kokichi; Hirohashi Setsuo
Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice.
Cancer science 2004;95(7):575-82.
2004: Nakayama Meijin; Sato Yu-ichi; Okamoto Makito; Hirohashi Setsuo
Increased expression of laminin-5 and its prognostic significance in hypopharyngeal cancer.
The Laryngoscope 2004;114(7):1259-63.
2004: Honda Kazufumi; Yamada Tesshi; Seike Masahiro; Hayashida Yasuharu; Idogawa Masashi; Kondo Tadashi; Ino Yoshinori; Hirohashi Setsuo
Alternative splice variant of actinin-4 in small cell lung cancer.
Oncogene 2004;23(30):5257-62.
2004: Chuma Makoto; Saeki Norihisa; Yamamoto Yoshiya; Ohta Tsutomu; Asaka Masahiro; Hirohashi Setsuo; Sakamoto Michiie
Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis.
The Keio journal of medicine 2004;53(2):90-7.
2004: Sonoda Itaru; Imoto Issei; Inoue Jun; Shibata Tatsuhiro; Shimada Yutaka; Chin Koei; Imamura Masayuki; Amagasa Teruo; Gray Joe W; Hirohashi Setsuo; Inazawa Johji
Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
Cancer research 2004;64(11):3741-7.
2004: Shibata Tatsuhiro; Kokubu Akiko; Sekine Shigeki; Kanai Yae; Hirohashi Setsuo
Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer.
The American journal of pathology 2004;164(6):2269-78.
2004: Shimada Yutaka; Yamasaki Seiji; Hashimoto Yosuke; Ito Tetsuo; Kawamura Jun-ichiro; Soma Toshiya; Ino Yoshinori; Nakanishi Yukihiro; Sakamoto Michiie; Hirohashi Setsuo; Imamura Masayuki
Clinical significance of dysadherin expression in gastric cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(8):2818-23.
2004: Yasui Wataru; Hirohashi Setsuo; Imai Kohzoh; Tahara Eiichi
New approaches to identification of biomarkers for early cancer detection: The Thirteenth International Symposium of the Hiroshima Cancer Seminar, October 2003.
Cancer science 2004;95(2):193-5.
2004: Etoh Tsuyoshi; Kanai Yae; Ushijima Saori; Nakagawa Tohru; Nakanishi Yukihiro; Sasako Mitsuru; Kitano Seigo; Hirohashi Setsuo
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
The American journal of pathology 2004;164(2):689-99.
2004: Shimada Yutaka; Hashimoto Yosuke; Kan Takatsugu; Kawamura Jun-ichiro; Okumura Tomoyuki; Soma Toshiya; Kondo Kan; Teratani Naoki; Watanabe Go; Ino Yoshinori; Sakamoto Michiie; Hirohashi Setsuo; Imamura Masayuki
Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma.
Oncology 2004;67(1):73-80.
2004: Yamada Yoichi; Itano Naoki; Narimatsu Hisashi; Kudo Takashi; Morozumi Kyoei; Hirohashi Setsuo; Ochiai Atsushi; Ueda Minoru; Kimata Koji
Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer.
Clinical & experimental metastasis 2004;21(1):57-63.
2004: Nam Jeong-Seok; Ino Yoshinori; Kanai Yae; Sakamoto Michiie; Hirohashi Setsuo
5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis.
Clinical & experimental metastasis 2004;21(1):49-56.
2003: Nakagawa Tohru; Kanai Yae; Saito Yoshimasa; Kitamura Tadaichi; Kakizoe Tadao; Hirohashi Setsuo
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
The Journal of urology 2003;170(6 Pt 1):2463-6.
2003: Tsuchiya Akira; Sakamoto Michiie; Yasuda Jun; Chuma Makoto; Ohta Tsutomu; Ohki Misao; Yasugi Toshiharu; Taketani Yuji; Hirohashi Setsuo
Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma.
The American journal of pathology 2003;163(6):2503-12.
2003: Sekine Shigeki; Sato Sunao; Takata Takashi; Fukuda Yasuo; Ishida Takeshi; Kishino Mitsunobu; Shibata Tatsuhiro; Kanai Yae; Hirohashi Setsuo
Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas.
The American journal of pathology 2003;163(5):1707-12.
2003: Kanetaka Kengo; Sakamoto Michiie; Yamamoto Yoshiya; Takamura Masaaki; Kanematsu Takashi; Hirohashi Setsuo
Possible involvement of tetraspanin CO-029 in hematogenous intrahepatic metastasis of liver cancer cells.
Journal of gastroenterology and hepatology 2003;18(11):1309-14.
2003: Yamada Yoichi; Itano Naoki; Narimatsu Hisashi; Kudo Takashi; Hirohashi Setsuo; Ochiai Atsushi; Tohnai Iwai; Ueda Minoru; Kimata Koji
CD44 variant exon 6 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptase-polymerase chain reaction.
Oncology reports 2003;10(6):1919-24.
2003: Kondo Tadashi; Seike Masahiro; Mori Yasuharu; Fujii Kazuyasu; Yamada Tesshi; Hirohashi Setsuo
Application of sensitive fluorescent dyes in linkage of laser microdissection and two-dimensional gel electrophoresis as a cancer proteomic study tool.
Proteomics 2003;3(9):1758-66.
2003: Sato Haruhiro; Ino Yoshinori; Miura Ayaka; Abe Yoshifumi; Sakai Hideto; Ito Koichi; Hirohashi Setsuo
Dysadherin: expression and clinical significance in thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2003;88(9):4407-12.
2003: Seike Masahiro; Kondo Tadashi; Mori Yasuharu; Gemma Akihiko; Kudoh Shoji; Sakamoto Michiie; Yamada Tesshi; Hirohashi Setsuo
Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin.
Cancer research 2003;63(15):4641-7.
2003: Yasuda Jun; Tsuchiya Akira; Yamada Tesshi; Sakamoto Michiie; Sekiya Takao; Hirohashi Setsuo
Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells.
Biochemical and biophysical research communications 2003;308(2):227-33.
2003: Hirohashi Setsuo; Kanai Yae
Cell adhesion system and human cancer morphogenesis.
Cancer science 2003;94(7):575-81.
2003: Shibata Tatsuhiro; Chuma Makoto; Kokubu Akiko; Sakamoto Michiie; Hirohashi Setsuo
EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2003;38(1):178-86.
2003: Terasaki Hiroshi; Niki Toshiro; Matsuno Yoshihiro; Yamada Tesshi; Maeshima Arafumi; Asamura Hisao; Hayabuchi Naofumi; Hirohashi Setsuo
Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization.
The American journal of surgical pathology 2003;27(7):937-51.
2003: Saito Yoshimasa; Kanai Yae; Nakagawa Tohru; Sakamoto Michiie; Saito Hidetsugu; Ishii Hiromasa; Hirohashi Setsuo
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
International journal of cancer. Journal international du cancer 2003;105(4):527-32.
2003: Tsuiji Hitomi; Takasaki Seiichi; Sakamoto Michiie; Irimura Tatsuro; Hirohashi Setsuo
Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion.
Glycobiology 2003;13(7):521-7.
2003: Sekine Shigeki; Shibata Tatsuhiro; Matsuno Yoshihiro; Maeshima Arafumi; Ishii Genichiro; Sakamoto Michiie; Hirohashi Setsuo
Beta-catenin mutations in pulmonary blastomas: association with morule formation.
The Journal of pathology 2003;200(2):214-21.
2003: Yoshimura Akinobu; Gemma Akihiko; Hosoya Yoko; Komaki Eriko; Hosomi Yukio; Okano Tetsuya; Takenaka Kiyosi; Matuda Kuniko; Seike Masahiro; Uematsu Kazutsugu; Hibino Suguru; Shibuya Masahiko; Yamada Tesshi; Hirohashi Setsuo; Kudoh Shoji
Increased expression of the LGALS3 (galectin 3) gene in human non-small-cell lung cancer.
Genes, chromosomes & cancer 2003;37(2):159-64.
2003: Takamura Masaaki; Sakamoto Michiie; Ino Yoshinori; Shimamura Takeshi; Ichida Takafumi; Asakura Hitoshi; Hirohashi Setsuo
Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas.
Cancer science 2003;94(5):425-30.
2003: Horikawa Yohei; Sugano Kokichi; Shigyo Masanori; Yamamoto Hidenobu; Nakazono Masaaki; Fujimoto Hiroyuki; Kanai Yae; Hirohashi Setsuo; Kakizoe Tadao; Habuchi Tomonori; Kato Tetsuro
Hypermethylation of an E-cadherin (CDH1) promoter region in high grade transitional cell carcinoma of the bladder comprising carcinoma in situ.
The Journal of urology 2003;169(4):1541-5.
2003: Kanai Yae; Ushijima Saori; Nakanishi Yukihiro; Sakamoto Michiie; Hirohashi Setsuo
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Cancer letters 2003;192(1):75-82.
2003: Aoki S; Shimamura T; Shibata T; Nakanishi Y; Moriya Y; Sato Y; Kitajima M; Sakamoto M; Hirohashi S
Prognostic significance of dysadherin expression in advanced colorectal carcinoma.
British journal of cancer 2003;88(5):726-32.
2003: Yamada Tesshi; Mori Yasuharu; Hayashi Reiko; Takada Mizuho; Ino Yoshinori; Naishiro Yasuyoshi; Kondo Tadashi; Hirohashi Setsuo
Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice.
Cancer research 2003;63(5):895-901.
2003: Yamamoto Yoshiya; Sakamoto Michiie; Fujii Gen; Tsuiji Hitomi; Kenetaka Kengo; Asaka Masahiro; Hirohashi Setsuo
Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations.
Hepatology (Baltimore, Md.) 2003;37(3):528-33.
2003: Shimamura Takeshi; Sakamoto Michiie; Ino Yoshinori; Sato Yasuto; Shimada Kazuaki; Kosuge Tomoo; Sekihara Hisahiko; Hirohashi Setsuo
Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to e-cadherin expression.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(4):659-67.
2003: Yamazaki Ken; Sakamoto Michiie; Ohta Tsutomu; Kanai Yae; Ohki Misao; Hirohashi Setsuo
Overexpression of KIT in chromophobe renal cell carcinoma.
Oncogene 2003;22(6):847-52.
2003: Chuma Makoto; Sakamoto Michiie; Yamazaki Ken; Ohta Tsutomu; Ohki Misao; Asaka Masahiro; Hirohashi Setsuo
Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2003;37(1):198-207.
2002: Sekine Shigeki; Shibata Tatsuhiro; Kokubu Akiko; Morishita Yukio; Noguchi Masayuki; Nakanishi Yukihiro; Sakamoto Michiie; Hirohashi Setsuo
Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations.
The American journal of pathology 2002;161(6):1997-2001.
2002: Aoki Seishi; Nakanishi Yukihiro; Akimoto Shingo; Moriya Yoshihiro; Yoshimura Kimio; Kitajima Masaki; Sakamoto Michiie; Hirohashi Setsuo
Prognostic significance of laminin-5 gamma2 chain expression in colorectal carcinoma: immunohistochemical analysis of 103 cases.
Diseases of the colon and rectum 2002;45(11):1520-7.
2002: Koizume Shiro; Tachibana Ken; Sekiya Takao; Hirohashi Setsuo; Shiraishi Masahiko
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.
Nucleic acids research 2002;30(21):4770-80.
2002: Nam Jeong-Seok; Ino Yoshinori; Sakamoto Michiie; Hirohashi Setsuo
Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.
Japanese journal of cancer research : Gann 2002;93(9):1020-8.
2002: Tsuda Hitoshi; Takarabe Teruko; Kanai Yae; Fukutomi Takashi; Hirohashi Setsuo
Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas.
The American journal of pathology 2002;161(3):859-66.
2002: Imoto Issei; Tsuda Hitoshi; Hirasawa Akira; Miura Masahiko; Sakamoto Masaru; Hirohashi Setsuo; Inazawa Johji
Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy.
Cancer research 2002;62(17):4860-6.
2002: Kubo Makoto; Sakamoto Michiie; Fukushima Noriyoshi; Yachida Shinichi; Nakanishi Yukihiro; Shimoda Tadakazu; Yamamoto Junji; Moriya Yoshihiro; Hirohashi Setsuo
Less aggressive features of colorectal cancer with liver metastases showing macroscopic intrabiliary extension.
Pathology international 2002;52(8):514-8.
2002: Hasegawa Tadashi; Yamamoto Seiichiro; Yokoyama Ryohei; Umeda Toru; Matsuno Yoshihiro; Hirohashi Setsuo
Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk.
Cancer 2002;95(4):843-51.
2002: Sekine Shigeki; Shibata Tatsuhiro; Sakamoto Michiie; Hirohashi Setsuo
Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype.
Oncogene 2002;21(38):5906-11.
2002: Shimamura Takeshi; Sakamoto Michiie; Ino Yoshinori; Shimada Kazuaki; Kosuge Tomoo; Sato Yasuto; Tanaka Katsuaki; Sekihara Hisahiko; Hirohashi Setsuo
Clinicopathological significance of galectin-3 expression in ductal adenocarcinoma of the pancreas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2570-5.
2002: Okada Satoshi; Tsuda Hitoshi; Takarabe Teruko; Yoshikawa Hiroyuki; Taketani Yuji; Hirohashi Setsuo
Allelotype analysis of common epithelial ovarian cancers with special reference to comparison between clear cell adenocarcinoma with other histological types.
Japanese journal of cancer research : Gann 2002;93(7):798-806.
2002: Nam Jeong-Seok; Ino Yoshinori; Sakamoto Michiie; Hirohashi Setsuo
Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2430-6.
2002: Saito Yoshimasa; Kanai Yae; Sakamoto Michiie; Saito Hidetsugu; Ishii Hiromasa; Hirohashi Setsuo
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10060-5.
2002: Yokoi Sana; Yasui Kohichiroh; Saito-Ohara Fumiko; Koshikawa Katsumi; Iizasa Toshihiko; Fujisawa Takehiko; Terasaki Takeo; Horii Akira; Takahashi Takashi; Hirohashi Setsuo; Inazawa Johji
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
The American journal of pathology 2002;161(1):207-16.
2002: Hasegawa Tadashi; Matsuno Yoshihiro; Shimoda Tadakazu; Hirohashi Setsuo
Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade.
Human pathology 2002;33(6):669-76.
2002: Maeshima Arafumi; Sakamoto Michiie; Hirohashi Setsuo
Mixed mucinous-type and non-mucinous-type adenocarcinoma of the lung: immunohistochemical examination and K- ras gene mutation.
Virchows Archiv : an international journal of pathology 2002;440(6):598-603.
2002: Fuchs Margit; Hutzler Peter; Brunner Ingrid; Schlegel Jürgen; Mages Jörg; Reuning Ute; Hapke Sandra; Duyster Justus; Hirohashi Setsuo; Genda Takuya; Sakamoto Michiie; Uberall Florian; Höfler Heinz; Becker Karl-Friedrich; Luber Birgit
Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and phosphatidylinositol 3-kinase inhibitors.
Experimental cell research 2002;276(2):129-41.
2002: Okada S; Tsuda Hitoshi; Ohmi K; Kasamatsu T; Yamada T; Tsunematsu R; Sumi M; Tokuuye K; Yoshikawa H; Hirohashi S
Immature glandular features in squamous cell carcinoma of the uterine cervix as an independent indicator of resistance to radiotherapy.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2002;12(3):277-85.
2002: Nakanishi Kazuaki; Sakamoto Michiie; Yasuda Jun; Takamura Masaaki; Fujita Naoya; Tsuruo Takashi; Todo Satoru; Hirohashi Setsuo
Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer.
Cancer research 2002;62(10):2971-5.
2002: Sekine Shigeki; Shibata Tatsuhiro; Yamauchi Yuko; Nakanishi Yukihiro; Shimoda Tadakazu; Sakamoto Michiie; Hirohashi Setsuo
Beta-catenin mutations in sporadic fundic gland polyps.
Virchows Archiv : an international journal of pathology 2002;440(4):381-6.
2002: Tsuda Hitoshi; Takarabe Teruko; Okada Satoshi; Uchida Hiroshi; Kasamatsu Takahiro; Yamada Takuro; Tsunematsu Ryuichiro; Ohmi Kazuo; Hirohashi Setsuo
Different pattern of loss of heterozygosity among endocervical-type adenocarcinoma, endometrioid-type adenocarcinoma and adenoma malignum of the uterine cervix.
International journal of cancer. Journal international du cancer 2002;98(5):713-7.
2002: Niki Toshiro; Kohno Takashi; Iba Sanae; Moriya Yasumitsu; Takahashi Yoko; Saito Miyuki; Maeshima Arafumi; Yamada Tesshi; Matsuno Yoshihiro; Fukayama Masashi; Yokota Jun; Hirohashi Setsuo
Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas.
The American journal of pathology 2002;160(3):1129-41.
2002: Gotoh Masahiro; Sakamoto Michiie; Kanetaka Kengo; Chuuma Makoto; Hirohashi Setsuo
Overexpression of osteopontin in hepatocellular carcinoma.
Pathology international 2002;52(1):19-24.
2002: Ino Yoshinori; Gotoh Masahiro; Sakamoto Michiie; Tsukagoshi Kiyomi; Hirohashi Setsuo
Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):365-70.
2002: Ono Yukiko; Nakanishi Yukihiro; Gotoh Masahiro; Sakamoto Michiie; Hirohashi Setsuo
Epidermal growth factor receptor gene amplification is correlated with laminin-5 gamma2 chain expression in oral squamous cell carcinoma cell lines.
Cancer letters 2002;175(2):197-204.
2002: Katoh Kazuhide; Nakanishi Yukihiro; Akimoto Shingo; Yoshimura Kimio; Takagi Minoru; Sakamoto Michiie; Hirohashi Setsuo
Correlation between laminin-5 gamma2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue.
Oncology 2002;62(4):318-26.
2001: Kanai Y; Ushijima S; Saito Y; Nakanishi Y; Sakamoto M; Hirohashi S
MRNA expression of genes altered by 5-azacytidine treatment in cancer cell lines is associated with clinicopathological parameters of human cancers.
Journal of cancer research and clinical oncology 2001;127(12):697-706.
2001: Kanetaka K; Sakamoto M; Yamamoto Y; Yamasaki S; Lanza F; Kanematsu T; Hirohashi S
Overexpression of tetraspanin CO-029 in hepatocellular carcinoma.
Journal of hepatology 2001;35(5):637-42.
2001: Takarabe T; Tsuda H; Okada S; Fukutomi T; Hirohashi S
Detection of numerical alterations of chromosome 1 in cytopathological specimens of breast tumors by chromogen in situ hybridization.
Pathology international 2001;51(10):786-91.
2001: Sakamoto M; Takamura M; Ino Y; Miura A; Genda T; Hirohashi S
Involvement of c-Src in carcinoma cell motility and metastasis.
Japanese journal of cancer research : Gann 2001;92(9):941-6.
2001: Fukushima N; Sakamoto M; Mukai K; Kanai Y; Shimada K; Kosuge T; Hirohashi S
Intraductal papillary components in invasive ductal carcinoma of the pancreas are associated with long-term survival of patients.
Human pathology 2001;32(8):834-41.
2001: Fukushima N; Mukai K; Sakamoto M; Hasebe T; Shimada K; Kosuge T; Kinoshita T; Hirohashi S
Invasive carcinoma derived from intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic and immunohistochemical study of eight cases.
Virchows Archiv : an international journal of pathology 2001;439(1):6-13.
2001: Hasegawa T; Matsuno Y; Shimoda T; Umeda T; Yokoyama R; Hirohashi S
Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2001;14(7):655-63.
2001: Tsuda H; Takarabe T; Akashi-Tanaka S; Fukutomi T; Hirohashi S
Pattern of chromosome 16q loss differs between an atypical proliferative lesion and an intraductal or invasive ductal carcinoma occurring subsequently in the same area of the breast.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2001;14(5):382-8.
2001: Tokunou M; Niki T; Eguchi K; Iba S; Tsuda H; Yamada T; Matsuno Y; Kondo H; Saitoh Y; Imamura H; Hirohashi S
c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma.
The American journal of pathology 2001;158(4):1451-63.
2001: Niki T; Iba S; Yamada T; Matsuno Y; Enholm B; Hirohashi S
Expression of vascular endothelial growth factor receptor 3 in blood and lymphatic vessels of lung adenocarcinoma.
The Journal of pathology 2001;193(4):450-7.
2001: Naishiro Y; Yamada T; Takaoka A S; Hayashi R; Hasegawa F; Imai K; Hirohashi S
Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation.
Cancer research 2001;61(6):2751-8.
2001: Hasegawa T; Yokoyama R; Matsuno Y; Shimoda T; Hirohashi S
Prognostic significance of histologic grade and nuclear expression of beta-catenin in synovial sarcoma.
Human pathology 2001;32(3):257-63.
2001: Nakanishi Y; Ochiai A; Kato H; Tachimori Y; Igaki H; Hirohashi S
Clinicopathological significance of tumor nest configuration in patients with esophageal squamous cell carcinoma.
Cancer 2001;91(6):1114-20.
2001: Takamura M; Sakamoto M; Genda T; Ichida T; Asakura H; Hirohashi S
Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632.
Hepatology (Baltimore, Md.) 2001;33(3):577-81.
2001: Saito Y; Kanai Y; Sakamoto M; Saito H; Ishii H; Hirohashi S
Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2001;33(3):561-8.
2001: Yamamoto Y; Sakamoto M; Fujii G; Kanetaka K; Asaka M; Hirohashi S
Cloning and characterization of a novel gene, DRH1, down-regulated in advanced human hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):297-303.
2001: Sato H; Hasegawa T; Kanai Y; Tsutsumi Y; Osamura Y; Abe Y; Sakai H; Hirohashi S
Expression of cadherins and their undercoat proteins (alpha-, beta-, and gamma-catenins and p120) and accumulation of beta-catenin with no gene mutations in synovial sarcoma.
Virchows Archiv : an international journal of pathology 2001;438(1):23-30.
2001: Kanai Y; Ushijima S; Kondo Y; Nakanishi Y; Hirohashi S
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
International journal of cancer. Journal international du cancer 2001;91(2):205-12.
2000: Zhu X; Kanai Y; Saito A; Kondo Y; Hirohashi S
Aberrant expression of beta-catenin and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinomas.
Pathology international 2000;50(12):945-52.
2000: Maruyama K; Ochiai A; Akimoto S; Nakamura S; Baba S; Moriya Y; Hirohashi S
Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer.
Oncology 2000;59(4):302-9.
2000: Tokunou M; Niki T; Saitoh Y; Imamura H; Sakamoto M; Hirohashi S
Altered expression of the ERM proteins in lung adenocarcinoma.
Laboratory investigation; a journal of technical methods and pathology 2000;80(11):1643-50.
2000: Kondo Y; Kanai Y; Sakamoto M; Mizokami M; Ueda R; Hirohashi S
Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2000;32(5):970-9.
2000: Hasegawa T; Seki K; Ono K; Hirohashi S
Angiomatoid (malignant) fibrous histiocytoma: a peculiar low-grade tumor showing immunophenotypic heterogeneity and ultrastructural variations.
Pathology international 2000;50(9):731-8.
2000: Yamada T; Takaoka A S; Naishiro Y; Hayashi R; Maruyama K; Maesawa C; Ochiai A; Hirohashi S
Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis.
Cancer research 2000;60(17):4761-6.
2000: Tsuda H; Takarabe T; Fukutomi T; Hirohashi S
Preferential occurrence of breast carcinomas with loss of chromosome 16q and der (16) t (1;16) / der (1;16) in middle-aged patients with hyperplasia of mammary glands.
Japanese journal of cancer research : Gann 2000;91(7):692-9.
2000: Niki T; Iba S; Tokunou M; Yamada T; Matsuno Y; Hirohashi S
Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2431-9.
2000: Takagi Y; Ui-Tei K; Hirohashi S
Adhesion-dependent tyrosine phosphorylation of enabled in Drosophila neuronal cell line.
Biochemical and biophysical research communications 2000;270(2):482-7.
2000: Genda T; Sakamoto M; Ichida T; Asakura H; Hirohashi S
Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells.
Laboratory investigation; a journal of technical methods and pathology 2000;80(3):387-94.
2000: Ishii Y; Ochiai A; Yamada T; Akimoto S; Yanagihara K; Kitajima M; Hirohashi S
Integrin alpha6beta4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer.
Gastroenterology 2000;118(3):497-506.
2000: Tsuda H; Takarabe T; Hasegawa F; Fukutomi T; Hirohashi S
Large, central acellular zones indicating myoepithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastases.
The American journal of surgical pathology 2000;24(2):197-202.
2000: Anami Y; Takeuchi T; Mase K; Yasuda J; Hirohashi S; Perucho M; Noguchi M
Amplotyping of microdissected, methanol-fixed lung carcinoma by arbitrarily primed polymerase chain reaction.
International journal of cancer. Journal international du cancer 2000;89(1):19-25.
2000: Kanai Y; Ushijima S; Tsuda H; Sakamoto M; Hirohashi S
Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis.
Cancer letters 2000;148(1):73-80.
2000: Hasegawa T; Yokoyama R; Lee Y H; Shimoda T; Beppu Y; Hirohashi S
Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma.
Oncology 2000;58(1):66-74.
1999: Hasegawa T; Matsuno Y; Shimoda T; Hasegawa F; Sano T; Hirohashi S
Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior.
Human pathology 1999;30(12):1464-73.
1999: Kondo Y; Kanai Y; Sakamoto M; Genda T; Mizokami M; Ueda R; Hirohashi S
Beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1999;90(12):1301-9.
1999: Sato H; Hasegawa T; Abe Y; Sakai H; Hirohashi S
Expression of E-cadherin in bone and soft tissue sarcomas: a possible role in epithelial differentiation.
Human pathology 1999;30(11):1344-9.
1999: Kanai Y; Ushijima S; Nakanishi Y; Hirohashi S
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Biochemical and biophysical research communications 1999;264(3):962-6.
1999: Tsuda H; Takarabe T; Hasegawa T; Murata T; Hirohashi S
Myoepithelial differentiation in high-grade invasive ductal carcinomas with large central acellular zones.
Human pathology 1999;30(10):1134-9.
1999: Genda T; Sakamoto M; Ichida T; Asakura H; Kojiro M; Narumiya S; Hirohashi S
Cell motility mediated by rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 1999;30(4):1027-36.
1999: Masui F; Matsuno Y; Yokoyama R; Nakanishi Y; Hasegawa T; Kanai Y; Beppu Y; Hirohashi S; Fujii K; Shimoda T
Synovial sarcoma, histologically mimicking primitive neuroectodermal tumor/Ewing's sarcoma at distant sites.
Japanese journal of clinical oncology 1999;29(9):438-41.
1999: Saito A; Kanai Y; Maesawa C; Ochiai A; Torii A; Hirohashi S
Disruption of E-cadherin-mediated cell adhesion systems in gastric cancers in young patients.
Japanese journal of cancer research : Gann 1999;90(9):993-9.
1999: Yamada Y; Itano N; Narimatsu H; Kudo T; Hirohashi S; Ochiai A; Niimi A; Ueda M; Kimata K
Receptor for hyaluronan-mediated motility and CD44 expressions in colon cancer assessed by quantitative analysis using real-time reverse transcriptase-polymerase chain reaction.
Japanese journal of cancer research : Gann 1999;90(9):987-92.
1999: Kondo Y; Kanai Y; Sakamoto M; Mizokami M; Ueda R; Hirohashi S
Microsatellite instability associated with hepatocarcinogenesis.
Journal of hepatology 1999;31(3):529-36.
1999: Tsuda H; Takarabe T; Hirohashi S
Correlation of numerical and structural status of chromosome 16 with histological type and grade of non-invasive and invasive breast carcinomas.
International journal of cancer. Journal international du cancer 1999;84(4):381-7.
1999: Ono Y; Nakanishi Y; Ino Y; Niki T; Yamada T; Yoshimura K; Saikawa M; Nakajima T; Hirohashi S
Clinocopathologic significance of laminin-5 gamma2 chain expression in squamous cell carcinoma of the tongue: immunohistochemical analysis of 67 lesions.
Cancer 1999;85(11):2315-21.
1999: Nakanishi Y; Ochiai A; Shimoda T; Yamaguchi H; Tachimori Y; Kato H; Watanabe H; Hirohashi S
Heterotopic sebaceous glands in the esophagus: histopathological and immunohistochemical study of a resected esophagus.
Pathology international 1999;49(4):364-8.
1999: Shimoyama Y; Takeda H; Yoshihara S; Kitajima M; Hirohashi S
Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin.
The Journal of biological chemistry 1999;274(17):11987-94.
1999: Harabayashi T; Kanai Y; Yamada T; Sakamoto M; Ochiai A; Kakizoe T; Koyanagi T; Hirohashi S
Reduction of integrin beta4 and enhanced migration on laminin in association with intraepithelial spreading of urinary bladder carcinomas.
The Journal of urology 1999;161(4):1364-71.
1999: Kanai Y; Hui A M; Sun L; Ushijima S; Sakamoto M; Tsuda H; Hirohashi S
DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 1999;29(3):703-9.
1999: Osada T; Sakamoto M; Nagawa H; Yamamoto J; Matsuno Y; Iwamatsu A; Muto T; Hirohashi S
Acquisition of glutamine synthetase expression in human hepatocarcinogenesis: relation to disease recurrence and possible regulation by ubiquitin-dependent proteolysis.
Cancer 1999;85(4):819-31.
1999: Tsuda H; Takarabe T; Fukutomi T; Hirohashi S
der(16)t(1;16)/der(1;16) in breast cancer detected by fluorescence in situ hybridization is an indicator of better patient prognosis.
Genes, chromosomes & cancer 1999;24(1):72-7.
1998: Saito A; Hasegawa T; Shimoda T; Toda G; Hirohashi S; Tajima G; Moriya Y
Dedifferentiated chordoma: a case report.
Japanese journal of clinical oncology 1998;28(12):766-71.
1998: Takaoka A S; Yamada T; Gotoh M; Kanai Y; Imai K; Hirohashi S
Cloning and characterization of the human beta4-integrin gene promoter and enhancers.
The Journal of biological chemistry 1998;273(50):33848-55.
1998: Hasegawa T; Matsuno Y; Niki T; Hirohashi S; Shimoda T; Takayama J; Watanabe C; Kaneko A; Sano T; Sato M; Suzuki J
Second primary rhabdomyosarcomas in patients with bilateral retinoblastoma: a clinicopathologic and immunohistochemical study.
The American journal of surgical pathology 1998;22(11):1351-60.
1998: Takayama T; Makuuchi M; Hirohashi S; Sakamoto M; Yamamoto J; Shimada K; Kosuge T; Okada S; Takayasu K; Yamasaki S
Early hepatocellular carcinoma as an entity with a high rate of surgical cure.
Hepatology (Baltimore, Md.) 1998;28(5):1241-6.
1998: Hui A M; Sun L; Kanai Y; Sakamoto M; Hirohashi S
Reduced p27Kip1 expression in hepatocellular carcinomas.
Cancer letters 1998;132(1-2):67-73.
1998: Sakamoto M; Hirohashi S
Natural history and prognosis of adenomatous hyperplasia and early hepatocellular carcinoma: multi-institutional analysis of 53 nodules followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or percutaneous ethanol injection.
Japanese journal of clinical oncology 1998;28(10):604-8.
1998: Akimoto S; Ochiai A; Inomata M; Hirohashi S
Expression of cadherin-catenin cell adhesion molecules, phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers.
Japanese journal of cancer research : Gann 1998;89(8):829-36.
1998: Fukuchi T; Sakamoto M; Tsuda H; Maruyama K; Nozawa S; Hirohashi S
Beta-catenin mutation in carcinoma of the uterine endometrium.
Cancer research 1998;58(16):3526-8.
1998: Hirohashi S
Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.
The American journal of pathology 1998;153(2):333-9.
1998: Maruyama K; Ochiai A; Nakamura S; Baba S; Hirohashi S
[Dysfunction of E-cadherin-catenin system in invasion and metastasis of colorectal cancer]
Nippon Geka Gakkai zasshi 1998;99(7):402-8.
1998: Tsuda H; Hirohashi S
Multiple developmental pathways of highly aggressive breast cancers disclosed by comparison of histological grades and c-erbB-2 expression patterns in both the non-invasive and invasive portions.
Pathology international 1998;48(7):518-25.
1998: Matsuno Y; Morozumi N; Hirohashi S; Shimosato Y; Rosai J
Papillary carcinoma of the thymus: report of four cases of a new microscopic type of thymic carcinoma.
The American journal of surgical pathology 1998;22(7):873-80.
1998: Hasebe T; Tsuda H; Hirohashi S; Shimosato Y; Tsubono Y; Yamamoto H; Mukai K
Fibrotic focus in infiltrating ductal carcinoma of the breast: a significant histopathological prognostic parameter for predicting the long-term survival of the patients.
Breast cancer research and treatment 1998;49(3):195-208.
1998: Sugitani S; Sakamoto M; Ichida T; Genda T; Asakura H; Hirohashi S
Hyperplastic foci reflect the risk of multicentric development of human hepatocellular carcinoma.
Journal of hepatology 1998;28(6):1045-53.
1998: Hasegawa T; Shimoda T; Hirohashi S; Hizawa K; Sano T
Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature.
Archives of pathology & laboratory medicine 1998;122(5):455-60.
1998: Yoshioka H; Takeuchi T; Matsuno Y; Yamada T; Shimosato Y; Hirohashi S; Noguchi M
Analysis of loss of heterozygosity in small adenocarcinomas of the lung.
Japanese journal of clinical oncology 1998;28(4):240-4.
1998: Nakanishi Y; Ochiai A; Yoshimura K; Kato H; Shimoda T; Yamaguchi H; Tachimori Y; Watanabe H; Hirohashi S
The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma: an analysis of 147 cases.
Cancer 1998;82(8):1454-9.
1998: Shimoyama Y; Shibata T; Kitajima M; Hirohashi S
Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin.
The Journal of biological chemistry 1998;273(16):10011-8.
1998: Tsuda H; Sakamaki C; Tsugane S; Fukutomi T; Hirohashi S
A prospective study of the significance of gene and chromosome alterations as prognostic indicators of breast cancer patients with lymph node metastases.
Breast cancer research and treatment 1998;48(1):21-32.
1998: Honda K; Yamada T; Endo R; Ino Y; Gotoh M; Tsuda H; Yamada Y; Chiba H; Hirohashi S
Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion.
The Journal of cell biology 1998;140(6):1383-93.
1998: Inomata M; Ochiai A; Sugihara K; Moriya Y; Yamaguchi N; Adachi Y; Kitano S; Hirohashi S
Macroscopic features at the deepest site of tumor penetration predicting liver metastases of colorectal cancer.
Japanese journal of clinical oncology 1998;28(2):123-8.
1998: Hasegawa T; Matsuno Y; Shimoda T; Hirohashi S; Hirose T; Sano T
Frequent expression of bcl-2 protein in solitary fibrous tumors.
Japanese journal of clinical oncology 1998;28(2):86-91.
1998: Tsuda H; Sakamaki C; Tsugane S; Fukutomi T; Hirohashi S
Prognostic significance of accumulation of gene and chromosome alterations and histological grade in node-negative breast carcinoma.
Japanese journal of clinical oncology 1998;28(1):5-11.
1998: Kanai Y; Ushijima S; Ochiai A; Eguchi K; Hui A; Hirohashi S
DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis.
Cancer letters 1998;122(1-2):135-41.
1998: Tsuda H; Takarabe T; Shimamura K; Hirohashi S
Detection of alterations in chromosomes 16 and 1 by fluorescence in situ hybridization in breast tumors cytologically or histologically equivocal for malignancy.
Pathobiology : journal of immunopathology, molecular and cellular biology 1998;66(6):268-73.
1997: Sun L; Hui A M; Kanai Y; Sakamoto M; Hirohashi S
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1997;88(12):1165-70.
1997: Yamada T; Endo R; Gotoh M; Hirohashi S
Identification of semaphorin E as a non-MDR drug resistance gene of human cancers.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14713-8.
1997: Eguchi K; Kanai Y; Kobayashi K; Hirohashi S
DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history.
Cancer research 1997;57(21):4913-5.
1997: Noguchi M; Furuya S; Takeuchi T; Hirohashi S
Modified formalin and methanol fixation methods for molecular biological and morphological analyses.
Pathology international 1997;47(10):685-91.
1997: Tsuda H; Takarabe T; Susumu N; Inazawa J; Okada S; Hirohashi S
Detection of numerical and structural alterations and fusion of chromosomes 16 and 1 in low-grade papillary breast carcinoma by fluorescence in situ hybridization.
The American journal of pathology 1997;151(4):1027-34.
1997: Morishita Y; Tsuda H; Fukutomi T; Mukai K; Shimosato Y; Hirohashi S
Clinicopathological characteristics of primary breast cancer in older geriatric women: a study of 39 Japanese patients over 80 years old.
Japanese journal of cancer research : Gann 1997;88(7):693-9.
1997: Osada T; Sakamoto M; Nishibori H; Iwaya K; Matsuno Y; Muto T; Hirohashi S
Increased ubiquitin immunoreactivity in hepatocellular carcinomas and precancerous lesions of the liver.
Journal of hepatology 1997;26(6):1266-73.
1997: Nakanishi Y; Ochiai A; Shimoda T; Yamaguchi H; Tachimori Y; Kato H; Watanabe H; Hirohashi S
Epidermization in the esophageal mucosa: unusual epithelial changes clearly detected by Lugol's staining.
The American journal of surgical pathology 1997;21(5):605-9.
1997: Kanai Y; Ushijima S; Hui A M; Ochiai A; Tsuda H; Sakamoto M; Hirohashi S
The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas.
International journal of cancer. Journal international du cancer 1997;71(3):355-9.
1997: Iwaya K; Nishibori H; Osada T; Matsuno Y; Tsuda H; Sato S; Kono H; Fukutomi T; Suzuki M; Torikata C; Iwamatsu A; Hirohashi S
Immunoreaction at 43 kDa with anti-ubiquitin antibody in breast neoplasms.
Japanese journal of cancer research : Gann 1997;88(3):273-80.
1997: Nakanishi Y; Ochiai A; Akimoto S; Kato H; Watanabe H; Tachimori Y; Yamamoto S; Hirohashi S
Expression of E-cadherin, alpha-catenin, beta-catenin and plakoglobin in esophageal carcinomas and its prognostic significance: immunohistochemical analysis of 96 lesions.
Oncology 1997;54(2):158-65.
1997: Hui A M; Kanai Y; Sakamoto M; Tsuda H; Hirohashi S
Reduced p21(WAF1/CIP1) expression and p53 mutation in hepatocellular carcinomas.
Hepatology (Baltimore, Md.) 1997;25(3):575-9.
1997: Lindsay C K; Thorgeirsson U P; Tsuda H; Hirohashi S
Expression of tissue inhibitor of metalloproteinase-1 and type IV collagenase/gelatinase messenger RNAs in human breast cancer.
Human pathology 1997;28(3):359-66.
1997: Iwaya K; Tsuda H; Fukutomi T; Tsugane S; Suzuki M; Hirohashi S
Histologic grade and p53 immunoreaction as indicators of early recurrence of node-negative breast cancer.
Japanese journal of clinical oncology 1997;27(1):6-12.
1997: Shibata T; Shimoyama Y; Gotoh M; Hirohashi S
Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.
The Journal of biological chemistry 1997;272(8):5236-40.
1997: Yasui N; Sakamoto M; Ochiai A; Ino Y; Akimoto S; Orikasa A; Kitajima M; Hirohashi S
Tumor growth and metastasis of human colorectal cancer cell lines in SCID mice resemble clinical metastatic behaviors.
Invasion & metastasis 1997;17(5):259-69.
1997: Tsuda H; Sakamaki C; Fukutomi T; Hirohashi S
Squamoid features and expression of involucrin in primary breast carcinoma associated with high histological grade, tumour cell necrosis and recurrence sites.
British journal of cancer 1997;75(10):1519-24.
1996: Kanai Y; Ushijima S; Tsuda H; Sakamoto M; Sugimura T; Hirohashi S
Aberrant DNA methylation on chromosome 16 is an early event in hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1996;87(12):1210-7.
1996: Osada T; Sakamoto M; Ino Y; Iwamatsu A; Matsuno Y; Muto T; Hirohashi S
E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 1996;24(6):1460-7.
1996: Ohsawa N; Sakamoto M; Saito T; Kobayashi M; Hirohashi S
Numerical chromosome aberrations in hepatocellular carcinoma detected by fluorescence in situ hybridization.
Journal of hepatology 1996;25(5):655-62.
1996: Yamada T; Endo R; Tsukagoshi K; Fujita S; Honda K; Kinoshita M; Hasebe T; Hirohashi S
Aberrant expression of a hemidesmosomal protein, bullous pemphigoid antigen 2, in human squamous cell carcinoma.
Laboratory investigation; a journal of technical methods and pathology 1996;75(4):589-600.
1996: Ono M; Sakamoto M; Ino Y; Moriya Y; Sugihara K; Muto T; Hirohashi S
Cancer cell morphology at the invasive front and expression of cell adhesion-related carbohydrate in the primary lesion of patients with colorectal carcinoma with liver metastasis.
Cancer 1996;78(6):1179-86.
1996: Hui A M; Sakamoto M; Kanai Y; Ino Y; Gotoh M; Yokota J; Hirohashi S
Inactivation of p16INK4 in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 1996;24(3):575-9.
1996: Muta H; Noguchi M; Kanai Y; Ochiai A; Nawata H; Hirohashi S
E-cadherin gene mutations in signet ring cell carcinoma of the stomach.
Japanese journal of cancer research : Gann 1996;87(8):843-8.
1996: Tsuda H; Sakamaki C; Shimamura K; Hirohashi S
Detection of allele loss on chromosome 16q in DNA isolated from fine needle aspiration specimens of breast tumors. A simulation study using surgically resected specimens.
Acta cytologica 1996;40(4):625-30.
1996: Nishibori H; Matsuno Y; Iwaya M; Osada T; Kubomura N; Iwamatsu A; Kohno H; Sato S; Kitajima M; Hirohashi S
Human colorectal carcinomas specifically accumulate Mr 42,000 ubiquitin-conjugated cytokeratin 8 fragments.
Cancer research 1996;56(12):2752-7.
1996: Inomata M; Ochiai A; Akimoto S; Kitano S; Hirohashi S
Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients.
Cancer research 1996;56(9):2213-7.
1996: Hasebe T; Tsuda H; Hirohashi S; Shimosato Y; Iwai M; Imoto S; Mukai K
Fibrotic focus in invasive ductal carcinoma: an indicator of high tumor aggressiveness.
Japanese journal of cancer research : Gann 1996;87(4):385-94.
1996: Cho J H; Noguchi M; Ochiai A; Hirohashi S
Loss of heterozygosity of multiple tumor suppressor genes in human gastric cancers by polymerase chain reaction.
Laboratory investigation; a journal of technical methods and pathology 1996;74(4):835-41.
1996: Shibata T; Ochiai A; Gotoh M; Machinami R; Hirohashi S
Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse-type gastric cancer.
Cancer letters 1996;99(2):147-53.
1996: Ochiai A; Yamauchi Y; Hirohashi S
p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia.
International journal of cancer. Journal international du cancer 1996;69(1):28-33.
1996: Sakamoto M; Ino Y; Ochiai A; Kanai Y; Akimoto S; Hirohashi S
Formation of focal adhesion and spreading of polarized human colon cancer cells in association with tyrosine phosphorylation of paxillin in response to phorbol ester.
Laboratory investigation; a journal of technical methods and pathology 1996;74(1):199-208.
1995: Tsuda H; Jiko K; Tsugane S; Yajima M; Yamada T; Tanemura K; Tsunematsu R; Ohmi K; Sonoda T; Hirohashi S
Prognostic value of p53 protein accumulation in cancer cell nuclei in adenocarcinoma of the uterine cervix.
Japanese journal of cancer research : Gann 1995;86(11):1049-53.
1995: Tsuda H; Hirohashi S
Identification of multiple breast cancers of multicentric origin by histological observations and distribution of allele loss on chromosome 16q.
Cancer research 1995;55(15):3395-8.
1995: Yoshiura K; Kanai Y; Ochiai A; Shimoyama Y; Sugimura T; Hirohashi S
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7416-9.
1995: Tsuda H; Jiko K; Yajima M; Yamada T; Tanemura K; Tsunematsu R; Ohmi K; Sonoda T; Hirohashi S
Frequent occurrence of c-Ki-ras gene mutations in well differentiated endometrial adenocarcinoma showing infiltrative local growth with fibrosing stromal response.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1995;14(3):255-9.
1995: Noguchi M; Morikawa A; Kawasaki M; Matsuno Y; Yamada T; Hirohashi S; Kondo H; Shimosato Y
Small adenocarcinoma of the lung. Histologic characteristics and prognosis.
Cancer 1995;75(12):2844-52.
1995: Iwaya K; Tsuda H; Fujita S; Suzuki M; Hirohashi S
Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues.
Laboratory investigation; a journal of technical methods and pathology 1995;72(6):707-14.
1995: Nakanishi Y; Noguchi M; Matsuno Y; Saikawa M; Mukai K; Shimosato Y; Hirohashi S
p53 expression in multicentric squamous cell carcinoma and surrounding squamous epithelium of the upper aerodigestive tract. Immunohistochemical analysis of 95 lesions.
Cancer 1995;75(7):1657-62.
1995: Kanai Y; Ochiai A; Shibata T; Oyama T; Ushijima S; Akimoto S; Hirohashi S
c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.
Biochemical and biophysical research communications 1995;208(3):1067-72.
1995: Kanai Y; Tsuda H; Oda T; Sakamoto M; Hirohashi S
Analysis of the neurofibromatosis 2 gene in human breast and hepatocellular carcinomas.
Japanese journal of clinical oncology 1995;25(1):1-4.
1995: Hasebe T; Sakamoto M; Mukai K; Kawano N; Konishi M; Ryu M; Fukamachi S; Hirohashi S
Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma.
Virchows Archiv : an international journal of pathology 1995;426(2):209-13.
1994: Jiko K; Tsuda H; Sato S; Hirohashi S
Pathogenetic significance of p53 and c-Ki-ras gene mutations and human papillomavirus DNA integration in adenocarcinoma of the uterine cervix and uterine isthmus.
International journal of cancer. Journal international du cancer 1994;59(5):601-6.
1994: Ochiai A; Akimoto S; Kanai Y; Shibata T; Oyama T; Hirohashi S
c-erbB-2 gene product associates with catenins in human cancer cells.
Biochemical and biophysical research communications 1994;205(1):73-8.
1994: Tsuda H; Uei Y; Fukutomi T; Hirohashi S
Different incidence of loss of heterozygosity on chromosome 16q between intraductal papilloma and intracystic papillary carcinoma of the breast.
Japanese journal of cancer research : Gann 1994;85(10):992-6.
1994: Kanai Y; Oda T; Tsuda H; Ochiai A; Hirohashi S
Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast.
Japanese journal of cancer research : Gann 1994;85(10):1035-9.
1994: Shibata T; Gotoh M; Ochiai A; Hirohashi S
Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.
Biochemical and biophysical research communications 1994;203(1):519-22.
1994: Oda T; Tsuda H; Sakamoto M; Hirohashi S
Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as a evidence for multistage progression.
Cancer letters 1994;83(1-2):197-200.
1994: Tsuda H; Mukai K; Fukutomi T; Hirohashi S
Malignant progression of adenomyoepithelial adenosis of the breast.
Pathology international 1994;44(6):475-9.
1994: Tsuda H; Hirohashi S
Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer.
International journal of cancer. Journal international du cancer 1994;57(4):498-503.
1994: Ochiai A; Akimoto S; Shimoyama Y; Nagafuchi A; Tsukita S; Hirohashi S
Frequent loss of alpha catenin expression in scirrhous carcinomas with scattered cell growth.
Japanese journal of cancer research : Gann 1994;85(3):266-73.
1994: Oda T; Kanai Y; Oyama T; Yoshiura K; Shimoyama Y; Birchmeier W; Sugimura T; Hirohashi S
E-cadherin gene mutations in human gastric carcinoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1858-62.
1994: Cho J H; Noguchi M; Ochiai A; Uchino S; Hirohashi S
Analysis of regional differences of p53 mutation in advanced gastric carcinoma: relation to heterogeneous differentiation and invasiveness.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(2):205-11.
1994: Aoki K; Sakamoto M; Hirohashi S
Nucleolar organizer regions in small nodular lesions representing early stages of human hepatocarcinogenesis.
Cancer 1994;73(2):289-93.
1994: Tsuda H; Callen D F; Fukutomi T; Nakamura Y; Hirohashi S
Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread.
Cancer research 1994;54(2):513-7.
1994: Kihana T; Tsuda H; Teshima S; Nomoto K; Tsugane S; Sonoda T; Matsuura S; Hirohashi S
Prognostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix.
Cancer 1994;73(1):148-53.
1994: Kanai Y; Oda T; Shimoyama Y; Ochiai A; Oyama T; Yoshiura K; Akimoto S; Yamada T; Hirohashi S
Alterations of the cadherin-catenin cell adhesion system in cancers.
Princess Takamatsu symposia 1994;24():51-62.
1993: Uchino S; Tsuda H; Maruyama K; Kinoshita T; Sasako M; Saito T; Kobayashi M; Hirohashi S
Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with long-term survival of patients.
Cancer 1993;72(11):3179-84.
1993: Yoshinaga Y; Matsuno Y; Fujita S; Nakamura T; Kikuchi M; Shimosato Y; Hirohashi S
Immunohistochemical detection of hepatocyte growth factor/scatter factor in human cancerous and inflammatory lesions of various organs.
Japanese journal of cancer research : Gann 1993;84(11):1150-8.
1993: Uchino S; Noguchi M; Ochiai A; Saito T; Kobayashi M; Hirohashi S
p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer.
International journal of cancer. Journal international du cancer 1993;54(5):759-64.
1993: Yamamoto T; Gotoh M; Kitajima M; Hirohashi S
Thymosin beta-4 expression is correlated with metastatic capacity of colorectal carcinomas.
Biochemical and biophysical research communications 1993;193(2):706-10.
1993: Yamamoto T; Gotoh M; Sasaki H; Terada M; Kitajima M; Hirohashi S
Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1.
Biochemical and biophysical research communications 1993;193(2):681-7.
1993: Oda T; Kanai Y; Shimoyama Y; Nagafuchi A; Tsukita S; Hirohashi S
Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line.
Biochemical and biophysical research communications 1993;193(3):897-904.
1993: Scarpa A; Capelli P; Mukai K; Zamboni G; Oda T; Iacono C; Hirohashi S
Pancreatic adenocarcinomas frequently show p53 gene mutations.
The American journal of pathology 1993;142(5):1534-43.
1993: Tsuda H; Hirohashi S
[Alterations of oncogenes in human cancers]
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(7):977-83.
1993: Scarpa A; Capelli P; Zamboni G; Oda T; Mukai K; Bonetti F; Martignoni G; Iacono C; Serio G; Hirohashi S
Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations.
The American journal of pathology 1993;142(4):1163-72.
1993: Tsuda H; Iwaya K; Fukutomi T; Hirohashi S
p53 mutations and c-erbB-2 amplification in intraductal and invasive breast carcinomas of high histologic grade.
Japanese journal of cancer research : Gann 1993;84(4):394-401.
1993: Sakamoto M; Ino Y; Fujii T; Hirohashi S
Phenotype changes in tumor vessels associated with the progression of hepatocellular carcinoma.
Japanese journal of clinical oncology 1993;23(2):98-104.
1993: Rim K S; Sakamoto M; Watanabe H; Matsuno Y; Nakanishi Y; Mukai K; Hirohashi S
Pathology and DNA cytophotometry of small hepatocellular carcinoma with a nodule-in-nodule appearance--evidence for stepwise progression of hepatocellular carcinoma.
Japanese journal of clinical oncology 1993;23(1):26-33.
1993: Kiba T; Tsuda H; Pairojkul C; Inoue S; Sugimura T; Hirohashi S
Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand.
Molecular carcinogenesis 1993;8(4):312-8.
1992: Yoshinaga Y; Fujita S; Gotoh M; Nakamura T; Kikuchi M; Hirohashi S
Human lung cancer cell line producing hepatocyte growth factor/scatter factor.
Japanese journal of cancer research : Gann 1992;83(12):1257-61.
1992: Fujita S; Suzuki H; Kinoshita M; Hirohashi S
Inhibition of cell attachment, invasion and metastasis of human carcinoma cells by anti-integrin beta 1 subunit antibody.
Japanese journal of cancer research : Gann 1992;83(12):1317-26.
1992: Tsuda H; Hirohashi S
Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes.
Japanese journal of cancer research : Gann 1992;83(11):1184-91.
1992: Oda T; Tsuda H; Scarpa A; Sakamoto M; Hirohashi S
p53 gene mutation spectrum in hepatocellular carcinoma.
Cancer research 1992;52(22):6358-64.
1992: Shimoyama Y; Nagafuchi A; Fujita S; Gotoh M; Takeichi M; Tsukita S; Hirohashi S
Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness.
Cancer research 1992;52(20):5770-4.
1992: Kihana T; Tsuda H; Teshima S; Okada S; Matsuura S; Hirohashi S
High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy.
Japanese journal of cancer research : Gann 1992;83(9):978-84.
1992: Tsuda H; Tsugane S; Fukutomi T; Nanasawa T; Yamamoto H; Hirohashi S
Prognostic factors for recurrent breast cancer: univariate and multivariate analyses including histologic grade and amplification of the c-erbB-2 proto-oncogene.
Japanese journal of clinical oncology 1992;22(4):244-9.
1992: Sugano S; Mukai K; Tsuda H; Hirohashi S; Furuya S; Shimosato Y; Ebihara S; Takeyama I
Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness.
The Laryngoscope 1992;102(8):923-7.
1992: Uchino S; Noguchi M; Hirota T; Itabashi M; Saito T; Kobayashi M; Hirohashi S
High incidence of nuclear accumulation of p53 protein in gastric cancer.
Japanese journal of clinical oncology 1992;22(4):225-31.
1992: Oda T; Tsuda H; Scarpa A; Sakamoto M; Hirohashi S
Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma.
Cancer research 1992;52(13):3674-8.
1992: Uchino S; Tsuda H; Noguchi M; Yokota J; Terada M; Saito T; Kobayashi M; Sugimura T; Hirohashi S
Frequent loss of heterozygosity at the DCC locus in gastric cancer.
Cancer research 1992;52(11):3099-102.
1992: Rubio C A; Hirota T; Itabashi M; Hirohashi S; Kato Y
Quantitation of gastric intestinal metaplasia by morphometry in Japanese patients.
Japanese journal of cancer research : Gann 1992;83(5):495-8.
1992: Sato Y; Mukai K; Furuya S; Kameya T; Hirohashi S
The AMeX method: a multipurpose tissue-processing and paraffin-embedding method. Extraction of protein and application to immunoblotting.
The American journal of pathology 1992;140(4):775-9.
1992: Tsuda H; Oda T; Sakamoto M; Hirohashi S
Different pattern of chromosomal allele loss in multiple hepatocellular carcinomas as evidence of their multifocal origin.
Cancer research 1992;52(6):1504-9.
1992: Noguchi M; Hirohashi S; Shimosato Y
Immunohistochemical detection of cluster 1 small cell lung cancer antigen and chromogranin A in lung carcinomas.
Japanese journal of clinical oncology 1992;22(1):6-9.
1992: Matsuno Y; Mukai K; Uhara H; Akao I; Furuya S; Sato Y; Hirohashi S; Shimosato Y
Detection of Epstein-Barr virus DNA in a Japanese case of lymphoepithelioma-like thymic carcinoma.
Japanese journal of cancer research : Gann 1992;83(2):127-30.
1992: Nomori H; Matsuno Y; Noguchi M; Tsugane S; Shimosato Y; Hirohashi S
Adenocarcinoma of the lung with selective metastasis to the lung: clinical, histologic and DNA-cytofluorometric analyses.
Japanese journal of cancer research : Gann 1992;83(1):93-100.
1992: Hiyoshi H; Matsuno Y; Kato H; Shimosato Y; Hirohashi S
Clinicopathological significance of nuclear accumulation of tumor suppressor gene p53 product in primary lung cancer.
Japanese journal of cancer research : Gann 1992;83(1):101-6.
1992: Tsuda H; Satarug S; Bhudhisawasdi V; Kihana T; Sugimura T; Hirohashi S
Cholangiocarcinomas in Japanese and Thai patients: difference in etiology and incidence of point mutation of the c-Ki-ras proto-oncogene.
Molecular carcinogenesis 1992;6(4):266-9.
1991: Rubio C; Hirota T; Itabashi M; Hirohashi S; Kato Y
A possible error in the interpretation of gastric carcinoma.
Japanese journal of cancer research : Gann 1991;82(12):1354-5.
1991: Shimoyama Y; Gotoh M; Ino Y; Sakamoto M; Kato K; Hirohashi S
Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1991;82(11):1263-70.
1991: Gotoh M; Nakajima T; Yokota J; Tsunokawa Y; Terada M; Shimoyama Y; Teshima S; Hirohashi S; Shimosato Y
Newly established uterine cervical carcinoma cell line with co-amplification of human papillomavirus DNA and c-myc gene.
Japanese journal of cancer research : Gann 1991;82(11):1252-7.
1991: Gemma A; Noguchi M; Hirohashi S; Tsugane S; Tsuchiya R; Niitani H; Shimosato Y
Clinicopathologic and immunohistochemical characteristics of goblet cell type adenocarcinoma of the lung.
Acta pathologica japonica 1991;41(10):737-43.
1991: Scarpa A; Borgato L; Chilosi M; Capelli P; Menestrina F; Bonetti F; Zamboni G; Pizzolo G; Hirohashi S; Fiore-Donati L
Evidence of c-myc gene abnormalities in mediastinal large B-cell lymphoma of young adult age.
Blood 1991;78(3):780-8.
1991: Iwaya K; Tsuda H; Hiraide H; Tamaki K; Tamakuma S; Fukutomi T; Mukai K; Hirohashi S
Nuclear p53 immunoreaction associated with poor prognosis of breast cancer.
Japanese journal of cancer research : Gann 1991;82(7):835-40.
1991: Shimoyama Y; Hirohashi S
Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma.
Cancer letters 1991;57(2):131-5.
1991: Shimoyama Y; Hirohashi S
Expression of E- and P-cadherin in gastric carcinomas.
Cancer research 1991;51(8):2185-92.
1991: Kihana T; Tsuda H; Hirota T; Shimosato Y; Sakamoto H; Terada M; Hirohashi S
Point mutation of c-Ki-ras oncogene in gastric adenoma and adenocarcinoma with tubular differentiation.
Japanese journal of cancer research : Gann 1991;82(3):308-14.
1991: Sakamoto M; Hirohashi S; Shimosato Y
Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma.
Human pathology 1991;22(2):172-8.
1991: Tsuda H; Hirohashi S; Hirota T; Shimosato Y
Alterations in copy number of c-erbB-2 and c-myc proto-oncogenes in advanced stage of human breast cancer.
Acta pathologica japonica 1991;41(1):19-23.
1991: Hirohashi S
Pathology and molecular mechanisms of multistage human hepatocarcinogenesis.
Princess Takamatsu symposia 1991;22():87-93.
1990: Yuki K; Hirohashi S; Sakamoto M; Kanai T; Shimosato Y
Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases.
Cancer 1990;66(10):2174-9.
1990: Noguchi M; Hirohashi S; Hara F; Kojima A; Shimosato Y; Shinkai T; Tsuchiya R
Heterogenous amplification of myc family oncogenes in small cell lung carcinoma.
Cancer 1990;66(10):2053-8.
1990: Matsuno Y; Hirohashi S; Furuya S; Sakamoto M; Mukai K; Shimosato Y
Heterogeneity of proliferative activity in nodule-in-nodule lesions of small hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1990;81(11):1137-40.
1990: Tsuda H; Zhang W D; Shimosato Y; Yokota J; Terada M; Sugimura T; Miyamura T; Hirohashi S
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6791-4.
1990: Kobayashi T; Tsuda H; Noguchi M; Hirohashi S; Shimosato Y; Goya T; Hayata Y
Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes.
Cancer 1990;66(2):289-94.
1990: Tsuda H; Hirohashi S; Higuchi K; Shimosato Y
Beta-2-microglobulin expression in relation to amplification of oncogenes and prognosis in breast carcinoma.
Histopathology 1990;16(5):500-2.
1990: Tsuda H; Hirohashi S; Shimosato Y; Tanaka Y; Hirota T; Tsugane S; Shiraishi M; Toyoshima K; Yamamoto T; Terada M
Immunohistochemical study on overexpression of c-erbB-2 protein in human breast cancer: its correlation with gene amplification and long-term survival of patients.
Japanese journal of cancer research : Gann 1990;81(4):327-32.
1990: Zhang W D; Hirohashi S; Tsuda H; Shimosato Y; Yokota J; Terada M; Sugimura T
Frequent loss of heterozygosity on chromosomes 16 and 4 in human hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1990;81(2):108-11.
1990: Mukai K; Sato Y; Hirohashi S; Shimosato Y
Expression of ras p21 protein by thymoma.
Virchows Archiv. B, Cell pathology including molecular pathology 1990;59(1):11-6.
1989: Koshiishi Y; Noguchi M; Nakajima T; Hirohashi S; Shimosato Y; Hayata Y
Immunohistochemical and immunoblot analyses of ras-p21 expression in lung carcinomas.
Acta pathologica japonica 1989;39(10):643-7.
1989: Tsuda H; Hirohashi S; Shimosato Y; Hirota T; Tsugane S; Yamamoto H; Miyajima N; Toyoshima K; Yamamoto T; Yokota J
Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.
Cancer research 1989;49(11):3104-8.
1989: Shimoyama Y; Hirohashi S; Hirano S; Noguchi M; Shimosato Y; Takeichi M; Abe O
Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.
Cancer research 1989;49(8):2128-33.
1989: Hirano T; Hirohashi S; Kunii T; Noguchi M; Shimosato Y; Hayata Y
Quantitative distribution of cluster 1 small cell lung cancer antigen in cancerous and non-cancerous tissues, cultured cells and sera.
Japanese journal of cancer research : Gann 1989;80(4):348-55.
1989: Tsuda H; Hirohashi S; Shimosato Y; Ino Y; Yoshida T; Terada M
Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1989;80(3):196-9.
1989: Noguchi M; Nakajima T; Hirohashi S; Akiba T; Shimosato Y
Immunohistochemical distinction of malignant mesothelioma from pulmonary adenocarcinoma with anti-surfactant apoprotein, anti-Lewisa, and anti-Tn antibodies.
Human pathology 1989;20(1):53-7.
1988: Noguchi M; Hirohashi S; Tsuda H; Nakajima T; Hara F; Shimosato Y
Detection of amplified N-myc gene in neuroblastoma by in situ hybridization using the single-step silver enhancement method.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1988;1(6):428-32.
1988: Teshima S; Shimosato Y; Hirohashi S; Tome Y; Hayashi I; Kanazawa H; Kakizoe T
Four new human germ cell tumor cell lines.
Laboratory investigation; a journal of technical methods and pathology 1988;59(3):328-36.
1988: Sakurai Y; Hirohashi S; Shimosato Y; Kodaira S; Abe O
Selection of a monoclonal antibody reactive with a high-molecular-weight glycoprotein circulating in the body fluid of gastrointestinal cancer patients.
Cancer research 1988;48(14):4053-8.
1988: Hirohashi S
[Analysis of oncogene and its expression at cellular level]
Human cell : official journal of Human Cell Research Society 1988;1(1):17-9.
1987: Kanai T; Hirohashi S; Noguchi M; Shimoyama Y; Shimosato Y; Noguchi S; Nishimura S; Abe O
Monoclonal antibody highly sensitive for the detection of ras p21 in immunoblotting analysis.
Japanese journal of cancer research : Gann 1987;78(12):1314-8.
1987: Kanai T; Hirohashi S; Upton M P; Ino Y; Shimosato Y
Expression of Lewis blood group antigens in cancerous and non-cancerous liver.
Japanese journal of cancer research : Gann 1987;78(9):968-76.

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