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Setsuo Hirohashi

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Yoshitomo Maehata; Minako Hirahashi; Shinichi Aishima; Junji Kishimoto; Setsuo Hirohashi; Takashi Yao; Hiroshi Takashima; Masazumi Tsuneyoshi; Yoshinao Oda
Significance of dysadherin and E-cadherin expression in differentiated-type gastric carcinoma with submucosal invasion.
Hideki Yokoo; Jun Yasuda; Kazuaki Nakanishi; Makoto Chuma; Toshiya Kamiyama; Satoru Todo; Setsuo Hirohashi; Michiie Sakamoto
Clinicopathological significance of nuclear factor-κB activation in hepatocellular carcinoma.
Eri Arai; Saori Wakai-Ushijima; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues.

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2011: Yoshitomo Maehata; Minako Hirahashi; Shinichi Aishima; Junji Kishimoto; Setsuo Hirohashi; Takashi Yao; Hiroshi Takashima; Masazumi Tsuneyoshi; Yoshinao Oda
Significance of dysadherin and E-cadherin expression in differentiated-type gastric carcinoma with submucosal invasion.
Human pathology 2011;42(4):558-67.
2011: Hideki Yokoo; Jun Yasuda; Kazuaki Nakanishi; Makoto Chuma; Toshiya Kamiyama; Satoru Todo; Setsuo Hirohashi; Michiie Sakamoto
Clinicopathological significance of nuclear factor-κB activation in hepatocellular carcinoma.
Hepatology research : the official journal of the Japan Society of Hepatology 2011;41(3):240-9.
2011: Eri Arai; Saori Wakai-Ushijima; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues.
Pathobiology : journal of immunopathology, molecular and cellular biology 2011;78(1):1-9.
2011: Junichi Matsubara; Kazufumi Honda; Masaya Ono; Yoshinori Tanaka; Michimoto Kobayashi; Giman Jung; Koji Yanagisawa; Tomohiro Sakuma; Shoji Nakamori; Naohiro Sata; Hideo Nagai; Tatsuya Ioka; Takuji Okusaka; Tomoo Kosuge; Akihiko Tsuchida; Masashi Shimahara; Yohichi Yasunami; Tsutomu Chiba; Setsuo Hirohashi; Tesshi Yamada
Reduced plasma level of CXC chemokine ligand 7 in patients with pancreatic cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011;20(1):160-71.
2011: Nobuyoshi Hiraoka; Rie Yamazaki-Itoh; Yoshinori Ino; Yasunori Mizuguchi; Tesshi Yamada; Setsuo Hirohashi; Yae Kanai
CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis.
Gastroenterology 2011;140(1):310-21.
2010: Tatsuhiro Shibata; Shigeru Saito; Akiko Kokubu; Takafumi Suzuki; Masayuki Yamamoto; Setsuo Hirohashi
Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway.
Cancer research 2010;70(22):9095-105.
2010: Reiko Satow; Miki Shitashige; Takafumi Jigami; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation.
The Journal of biological chemistry 2010;285(34):26289-94.
2010: Yuri Akishima-Fukasawa; Yoshinori Ino; Yukihiro Nakanishi; Ayaka Miura; Yoshihiro Moriya; Tadashi Kondo; Yae Kanai; Setsuo Hirohashi
Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma.
American journal of clinical pathology 2010;134(1):71-9.
2010: Miki Shitashige; Reiko Satow; Takafumi Jigami; Kazunori Aoki; Kazufumi Honda; Tatsuhiro Shibata; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth.
Cancer research 2010;70(12):5024-33.
2010: Kazutaka Kikuta; Naobumi Tochigi; Shigeru Saito; Tadakazu Shimoda; Hideo Morioka; Yoshiaki Toyama; Ako Hosono; Yoshiyuki Suehara; Yasuo Beppu; Akira Kawai; Setsuo Hirohashi; Tadashi Kondo
Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics.
Proteomics. Clinical applications 2010;4(5):560-7.
2010: Reiko Satow; Miki Shitashige; Yae Kanai; Fumitaka Takeshita; Hidenori Ojima; Takafumi Jigami; Kazufumi Honda; Tomoo Kosuge; Takahiro Ochiya; Setsuo Hirohashi; Tesshi Yamada
Combined functional genome survey of therapeutic targets for hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(9):2518-28.
2010: Hidenori Ojima; Daitaro Yoshikawa; Yoshihiro Ino; Hiroko Shimizu; Masashi Miyamoto; Akiko Kokubu; Nobuyoshi Hiraoka; Noriaki Morofuji; Tadashi Kondo; Hiroaki Onaya; Takuji Okusaka; Kazuaki Shimada; Yoshihiro Sakamoto; Minoru Esaki; Satoshi Nara; Tomoo Kosuge; Setsuo Hirohashi; Yae Kanai; Tatsuhiro Shibata
Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment.
Cancer science 2010;101(4):882-8.
2010: Junichi Matsubara; Masaya Ono; Kazufumi Honda; Ayako Negishi; Hideki Ueno; Takuji Okusaka; Junji Furuse; Koh Furuta; Emiko Sugiyama; Yoshiro Saito; Nahoko Kaniwa; Junichi Sawada; Ayako Shoji; Tomohiro Sakuma; Tsutomu Chiba; Nagahiro Saijo; Setsuo Hirohashi; Tesshi Yamada
Survival prediction for pancreatic cancer patients receiving gemcitabine treatment.
Molecular & cellular proteomics : MCP 2010;9(4):695-704.
2010: Eisuke Kobayashi; Mari Masuda; Robert Nakayama; Hitoshi Ichikawa; Reiko Satow; Miki Shitashige; Kazufumi Honda; Umio Yamaguchi; Ayako Shoji; Naobumi Tochigi; Hideo Morioka; Yoshiaki Toyama; Setsuo Hirohashi; Akira Kawai; Tesshi Yamada
Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma.
Molecular cancer therapeutics 2010;9(3):535-44.
2010: Kazutaka Kikuta; Masahiro Gotoh; Tatsuo Kanda; Naobumi Tochigi; Tadakazu Shimoda; Tadashi Hasegawa; Hitoshi Katai; Yasuhiro Shimada; Yoshiyuki Suehara; Akira Kawai; Setsuo Hirohashi; Tadashi Kondo
Pfetin as a prognostic biomarker in gastrointestinal stromal tumor: novel monoclonal antibody and external validation study in multiple clinical facilities.
Japanese journal of clinical oncology 2010;40(1):60-72.
2010: Naotaka Nishiyama; Eri Arai; Yoshitomo Chihara; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Taiji Tsukamoto; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage.
Cancer science 2010;101(1):231-40.
2009: Eri Arai; Saori Ushijima; Masahiro Gotoh; Hidenori Ojima; Tomoo Kosuge; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma.
International journal of cancer. Journal international du cancer 2009;125(12):2854-62.
2009: Umio Yamaguchi; Kazufumi Honda; Reiko Satow; Eisuke Kobayashi; Robert Nakayama; Hitoshi Ichikawa; Ayako Shoji; Miki Shitashige; Mari Masuda; Akira Kawai; Hirokazu Chuman; Yukihide Iwamoto; Setsuo Hirohashi; Tesshi Yamada
Functional genome screen for therapeutic targets of osteosarcoma.
Cancer science 2009;100(12):2268-74.
2009: Takashi Kubo; Yukie Kuroda; Hiroko Shimizu; Akiko Kokubu; Naoko Okada; Fumie Hosoda; Yasuhito Arai; Yu Nakamura; Hirokazu Taniguchi; Kazuyoshi Yanagihara; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Tatsuhiro Shibata
Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer.
Carcinogenesis 2009;30(11):1857-64.
2009: Masaya Ono; Junichi Matsubara; Kazufumi Honda; Tomohiro Sakuma; Tomoyo Hashiguchi; Hiroshi Nose; Shoji Nakamori; Takuji Okusaka; Tomoo Kosuge; Naohiro Sata; Hideo Nagai; Tatsuya Ioka; Sachiko Tanaka; Akihiko Tsuchida; Tatsuya Aoki; Masashi Shimahara; Yohichi Yasunami; Takao Itoi; Fuminori Moriyasu; Ayako Negishi; Hideya Kuwabara; Ayako Shoji; Setsuo Hirohashi; Tesshi Yamada
Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics.
The Journal of biological chemistry 2009;284(42):29041-9.
2009: Yu Nakamura; Toshiro Migita; Fumie Hosoda; Naoko Okada; Masahiro Gotoh; Yasuhito Arai; Michiyo Fukushima; Misao Ohki; Satoshi Miyata; Kengo Takeuchi; Issei Imoto; Hitoshi Katai; Toshiharu Yamaguchi; Johji Inazawa; Setsuo Hirohashi; Yuichi Ishikawa; Tatsuhiro Shibata
Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression.
International journal of cancer. Journal international du cancer 2009;125(8):1859-67.
2009: Tatsuhiro Shibata; Akiko Kokubu; Koji Tsuta; Setsuo Hirohashi
Oncogenic mutation of PIK3CA in small cell lung carcinoma: a potential therapeutic target pathway for chemotherapy-resistant lung cancer.
Cancer letters 2009;283(2):203-11.
2009: Takashi Kubo; Yukie Kuroda; Akiko Kokubu; Fumie Hosoda; Yasuhito Arai; Nobuyoshi Hiraoka; Setsuo Hirohashi; Tatsuhiro Shibata
Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer.
Pancreas 2009;38(7):e200-6.
2009: Kohei Shomori; Atsushi Ochiai; Shingo Akimoto; Yoshinori Ino; Koyo Shudo; Hisao Ito; Setsuo Hirohashi
Tyrosine-phosphorylation of the 12th armadillo-repeat of beta-catenin is associated with cadherin dysfunction in human cancer.
International journal of oncology 2009;35(3):517-24.
2009: Norihisa Uemura; Yukihiro Nakanishi; Hoichi Kato; Masato Nagino; Setsuo Hirohashi; Tadashi Kondo
Antibody-based proteomics for esophageal cancer: Identification of proteins in the nuclear factor-kappaB pathway and mitotic checkpoint.
Cancer science 2009;100(9):1612-22.
2009: Ayako Negishi; Mari Masuda; Masaya Ono; Kazufumi Honda; Miki Shitashige; Reiko Satow; Tomohiro Sakuma; Hideya Kuwabara; Yukihiro Nakanishi; Yae Kanai; Ken Omura; Setsuo Hirohashi; Tesshi Yamada
Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma.
Cancer science 2009;100(9):1605-11.
2009: Yuri Akishima-Fukasawa; Yukihiro Nakanishi; Yoshinori Ino; Yoshihiro Moriya; Yae Kanai; Setsuo Hirohashi
Prognostic significance of CXCL12 expression in patients with colorectal carcinoma.
American journal of clinical pathology 2009;132(2):202-10; quiz 307.
2009: Junichi Matsubara; Masaya Ono; Ayako Negishi; Hideki Ueno; Takuji Okusaka; Junji Furuse; Koh Furuta; Emiko Sugiyama; Yoshiro Saito; Nahoko Kaniwa; Junichi Sawada; Kazufumi Honda; Tomohiro Sakuma; Tsutomu Chiba; Nagahiro Saijo; Setsuo Hirohashi; Tesshi Yamada
Identification of a predictive biomarker for hematologic toxicities of gemcitabine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(13):2261-8.
2009: Norihisa Uemura; Yukihiro Nakanishi; Hoichi Kato; Shigeru Saito; Masato Nagino; Setsuo Hirohashi; Tadashi Kondo
Transglutaminase 3 as a prognostic biomarker in esophageal cancer revealed by proteomics.
International journal of cancer. Journal international du cancer 2009;124(9):2106-15.
2009: D Yoshikawa; Hidenori Ojima; Akiko Kokubu; T Ochiya; S Kasai; Setsuo Hirohashi; Tatsuhiro Shibata
Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma.
British journal of cancer 2009;100(8):1257-66.
2009: Kazutaka Kikuta; Naobumi Tochigi; Tadakazu Shimoda; Hiroki Yabe; Hideo Morioka; Yoshiaki Toyama; Ako Hosono; Yasuo Beppu; Akira Kawai; Setsuo Hirohashi; Tadashi Kondo
Nucleophosmin as a candidate prognostic biomarker of Ewing's sarcoma revealed by proteomics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(8):2885-94.
2009: Ken Yamazaki; Masaaki Takamura; Yohei Masugi; Taisuke Mori; Wenlin Du; Taizo Hibi; Nobuyoshi Hiraoka; Tsutomu Ohta; Misao Ohki; Setsuo Hirohashi; Michiie Sakamoto
Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility.
Laboratory investigation; a journal of technical methods and pathology 2009;89(4):425-32.
2009: Ayako Negishi; Masaya Ono; Yasushi Handa; Hidenori Kato; Kohki Yamashita; Kazufumi Honda; Miki Shitashige; Reiko Satow; Tomohiro Sakuma; Hideya Kuwabara; Ken Omura; Setsuo Hirohashi; Tesshi Yamada
Large-scale quantitative clinical proteomics by label-free liquid chromatography and mass spectrometry.
Cancer science 2009;100(3):514-9.
2009: Eri Arai; Saori Ushijima; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome.
Carcinogenesis 2009;30(2):214-21.
2009: Tadashi Kondo; Setsuo Hirohashi
Application of 2D-DIGE in cancer proteomics toward personalized medicine.
Methods in molecular biology (Clifton, N.J.) 2009;577():135-54.
2009: Takahiro Yamanashi; Yukihiro Nakanishi; Gen Fujii; Yuri Akishima-Fukasawa; Yoshihiro Moriya; Yae Kanai; Masahiko Watanabe; Setsuo Hirohashi
Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma.
Oncology 2009;77(1):53-62.
2009: Hidenori Ojima; Yae Kanai; Motoki Iwasaki; Nobuyoshi Hiraoka; Kazuaki Shimada; Tsuyoshi Sano; Yoshihiro Sakamoto; Minoru Esaki; Tomoo Kosuge; Michiie Sakamoto; Setsuo Hirohashi
Intraductal carcinoma component as a favorable prognostic factor in biliary tract carcinoma.
Cancer science 2009;100(1):62-70.
2008: Tatsuya Orimo; Hidenori Ojima; Nobuyoshi Hiraoka; Shigeru Saito; Tomoo Kosuge; Tatsuhiko Kakisaka; Hideki Yokoo; Kazuaki Nakanishi; Toshiya Kamiyama; Satoru Todo; Setsuo Hirohashi; Tadashi Kondo
Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2008;48(6):1851-63.
2008: Tatsuhiro Shibata; Akiko Kokubu; Masahiro Gotoh; Hidenori Ojima; Tsutomu Ohta; Masayuki Yamamoto; Setsuo Hirohashi
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer.
Gastroenterology 2008;135(4):1358-1368, 1368.e1-4.
2008: Tatsuhiro Shibata; Tsutomu Ohta; Kit I Tong; Akiko Kokubu; Reiko Odogawa; Koji Tsuta; Hisao Asamura; Masayuki Yamamoto; Setsuo Hirohashi
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13568-73.
2008: Eri Arai; Saori Ushijima; Hitoshi Tsuda; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5531-9.
2008: Satoru Kikuchi; Kazufumi Honda; Hitoshi Tsuda; Nobuyoshi Hiraoka; Issei Imoto; Tomoo Kosuge; Tomoko Umaki; Kaoru Onozato; Miki Shitashige; Umio Yamaguchi; Masaya Ono; Akihiko Tsuchida; Tatsuya Aoki; Johji Inazawa; Setsuo Hirohashi; Tesshi Yamada
Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5348-56.
2008: Umio Yamaguchi; Robert Nakayama; Kazufumi Honda; Hitoshi Ichikawa; Tadashi Hasegawa; Miki Shitashige; Masaya Ono; Ayako Shoji; Tomohiro Sakuma; Hideya Kuwabara; Yasuhiro Shimada; Mitsuru Sasako; Tadakazu Shimoda; Akira Kawai; Setsuo Hirohashi; Tesshi Yamada
Distinct gene expression-defined classes of gastrointestinal stromal tumor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(25):4100-8.
2008: S Hanada; A Maeshima; Y Matsuno; T Ohta; M Ohki; T Yoshida; Y Hayashi; Y Yoshizawa; Setsuo Hirohashi; M Sakamoto
Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression.
The Journal of pathology 2008;216(1):75-82.
2008: Akira Kawai; Tadashi Kondo; Yoshiyuki Suehara; Kazutaka Kikuta; Setsuo Hirohashi
Global protein-expression analysis of bone and soft tissue sarcomas.
Clinical orthopaedics and related research 2008;466(9):2099-106.
2008: Mako Narisawa-Saito; Yuki Yoshimatsu; Shin-ichi Ohno; Takashi Yugawa; Nagayasu Egawa; Masatoshi Fujita; Setsuo Hirohashi; Tohru Kiyono
An in vitro multistep carcinogenesis model for human cervical cancer.
Cancer research 2008;68(14):5699-705.
2008: Ryoko Kikuchi; Hitoshi Tsuda; Ken-ichi Kozaki; Yae Kanai; Takahiro Kasamatsu; Kazuo Sengoku; Setsuo Hirohashi; Johji Inazawa; Issei Imoto
Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer.
Cancer research 2008;68(13):5067-75.
2008: Miki Shitashige; Reiko Satow; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Regulation of Wnt signaling by the nuclear pore complex.
Gastroenterology 2008;134(7):1961-71, 1971.e1-4.
2008: Ayako Suzuki; Tatsuhiro Shibata; Yutaka Shimada; Yoshinori Murakami; Akira Horii; Keiko Shiratori; Setsuo Hirohashi; Johji Inazawa; Issei Imoto
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer science 2008;99(5):986-94.
2008: Miki Shitashige; Setsuo Hirohashi; Tesshi Yamada
Wnt signaling inside the nucleus.
Cancer science 2008;99(4):631-7.
2008: Kimie Sai; Yoshiro Saito; Hiromi Sakamoto; Kuniaki Shirao; Koichi Kurose; Mayumi Saeki; Shogo Ozawa; Nahoko Kaniwa; Setsuo Hirohashi; Nagahiro Saijo; Jun-ichi Sawada; Teruhiko Yoshida
Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients.
Cancer letters 2008;261(2):165-71.
2008: Yoshiyuki Suehara; Tadashi Kondo; Kunihiko Seki; Tatsuhiro Shibata; Kiyonaga Fujii; Masahiro Gotoh; Tadashi Hasegawa; Yasuhiro Shimada; Mitsuru Sasako; Tadakazu Shimoda; Hisashi Kurosawa; Yasuo Beppu; Akira Kawai; Setsuo Hirohashi
Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(6):1707-17.
2008: Tsutomu Ohta; Kumiko Iijima; Mamiko Miyamoto; Izumi Nakahara; Hiroshi Tanaka; Makiko Ohtsuji; Takafumi Suzuki; Akira Kobayashi; Jun Yokota; Tokuki Sakiyama; Tatsuhiro Shibata; Masayuki Yamamoto; Setsuo Hirohashi
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.
Cancer research 2008;68(5):1303-9.
2008: D Yoshikawa; H Ojima; M Iwasaki; N Hiraoka; T Kosuge; S Kasai; Setsuo Hirohashi; T Shibata
Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma.
British journal of cancer 2008;98(2):418-25.
2008: Hiroki Ochiai; Yukihiro Nakanishi; Yuri Fukasawa; Yasunori Sato; Kimio Yoshimura; Yoshihiro Moriya; Yae Kanai; Masahiko Watanabe; Hirotoshi Hasegawa; Yuko Kitagawa; Masaki Kitajima; Setsuo Hirohashi
A new formula for predicting liver metastasis in patients with colorectal cancer: immunohistochemical analysis of a large series of 439 surgically resected cases.
Oncology 2008;75(1-2):32-41.
2008: Anna Batistatou; Konstantinos Charalabopoulos; Yukihiro Nakanishi; Constantine Vagianos; Setsuo Hirohashi; Niki J Agnantis; Chrisoula D Scopa
Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin.
Endocrine pathology 2008;19(3):197-202.
2007: Yukihiro Yoshida; Akiko Kokubu; Kenji Suzuki; Hidehiko Kuribayashi; Koji Tsuta; Yoshihiro Matsuno; Masahiko Kusumoto; Yae Kanai; Hisao Asamura; Setsuo Hirohashi; Tatsuhiro Shibata
Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity.
Japanese journal of clinical oncology 2007;37(12):907-12.
2007: Miki Shitashige; Reiko Satow; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.
Cancer science 2007;98(12):1862-7.
2007: Yae Kanai; Setsuo Hirohashi
Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state.
Carcinogenesis 2007;28(12):2434-42.
2007: Lin Huang; Miki Shitashige; Reiko Satow; Kazufumi Honda; Masaya Ono; Jisoo Yun; Akihiro Tomida; Takashi Tsuruo; Setsuo Hirohashi; Tesshi Yamada
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
Gastroenterology 2007;133(5):1569-78.
2007: Hiroto Katoh; Hidenori Ojima; Akiko Kokubu; Shigeru Saito; Tadashi Kondo; Tomoo Kosuge; Fumie Hosoda; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Tatsuhiro Shibata
Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.
Gastroenterology 2007;133(5):1475-86.
2007: Jeong-Seok Nam; Setsuo Hirohashi; Lalage M Wakefield
Dysadherin: a new player in cancer progression.
Cancer letters 2007;255(2):161-9.
2007: Ryoko Kikuchi; Hitoshi Tsuda; Yae Kanai; Takahiro Kasamatsu; Kazuo Sengoku; Setsuo Hirohashi; Johji Inazawa; Issei Imoto
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Cancer research 2007;67(15):7095-105.
2007: Tatsuhiro Shibata; Satoko Hanada; Akiko Kokubu; Yoshihiro Matsuno; Hisao Asamura; Tsutomu Ohta; Michiie Sakamoto; Setsuo Hirohashi
Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma.
Cancer science 2007;98(7):985-91.
2007: Morio Sawada; Yae Kanai; Eri Arai; Saori Ushijima; Hidenori Ojima; Setsuo Hirohashi
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Cancer letters 2007;251(2):211-9.
2007: Satoru Kikuchi; Kazufumi Honda; Yasushi Handa; Hidenori Kato; Kohki Yamashita; Tomoko Umaki; Miki Shitashige; Masaya Ono; Akihiko Tsuchida; Tatsuya Aoki; Setsuo Hirohashi; Tesshi Yamada
Serum albumin-associated peptides of patients with uterine endometrial cancer.
Cancer science 2007;98(6):822-9.
2007: Tatsuhiko Kakisaka; Tadashi Kondo; Tetsuya Okano; Kiyonaga Fujii; Kazufumi Honda; Mitsufumi Endo; Akihiko Tsuchida; Tatsuya Aoki; Takao Itoi; Fuminori Moriyasu; Tesshi Yamada; Harubumi Kato; Toshihide Nishimura; Satoru Todo; Setsuo Hirohashi
Plasma proteomics of pancreatic cancer patients by multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis (2D-DIGE): up-regulation of leucine-rich alpha-2-glycoprotein in pancreatic cancer.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;852(1-2):257-67.
2007: Anna Batistatou; Dimitrios Peschos; H Tsanou; Alexander Charalabopoulos; Y Nakanishi; Setsuo Hirohashi; Niki J Agnantis; Konstantinos Charalabopoulos
In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin.
British journal of cancer 2007;96(9):1404-8.
2007: Hideki Yokoo; Tadashi Kondo; Tetsuya Okano; Kazuaki Nakanishi; Michiie Sakamoto; Tomoo Kosuge; Satoru Todo; Setsuo Hirohashi
Protein expression associated with early intrahepatic recurrence of hepatocellular carcinoma after curative surgery.
Cancer science 2007;98(5):665-73.
2007: Miki Shitashige; Yasuyoshi Naishiro; Masashi Idogawa; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing.
Gastroenterology 2007;132(3):1039-54.
2007: Panayiotis Loukopoulos; Tatsuhiro Shibata; Hiroto Katoh; Akiko Kokubu; Michiie Sakamoto; Ken Yamazaki; Tomoo Kosuge; Yae Kanai; Fumie Hosoda; Issei Imoto; Misao Ohki; Johji Inazawa; Setsuo Hirohashi
Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome.
Cancer science 2007;98(3):392-400.
2007: Tomohiko Hara; Kazufumi Honda; Miki Shitashige; Masaya Ono; Hideyasu Matsuyama; Katsusuke Naito; Setsuo Hirohashi; Tesshi Yamada
Mass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells.
Molecular & cellular proteomics : MCP 2007;6(3):479-91.
2007: Noritoshi Kobayashi; Nobuyoshi Hiraoka; Wataru Yamagami; Hidenori Ojima; Yae Kanai; Tomoo Kosuge; Atsushi Nakajima; Setsuo Hirohashi
FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):902-11.
2007: Tetsuya Okano; Tadashi Kondo; Kiyonaga Fujii; Toshihide Nishimura; Toshimi Takano; Yuichiro Ohe; Koji Tsuta; Yoshihiro Matsuno; Akihiko Gemma; Harbumi Kato; Shoji Kudoh; Setsuo Hirohashi
Proteomic signature corresponding to the response to gefitinib (Iressa, ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor in lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(3):799-805.
2007: Masashi Idogawa; Mitsuko Masutani; Miki Shitashige; Kazufumi Honda; Takashi Tokino; Yasuhisa Shinomura; Kohzoh Imai; Setsuo Hirohashi; Tesshi Yamada
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
Cancer research 2007;67(3):911-8.
2007: Teiyu Izumi; Yoshinao Oda; Tadashi Hasegawa; Yukihiro Nakanishi; Akira Kawai; Hiroshi Sonobe; Tomonari Takahira; Chikashi Kobayashi; Hidetaka Yamamoto; Sadafumi Tamiya; Setsuo Hirohashi; Yukihide Iwamoto; Masazumi Tsuneyoshi
Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression.
The American journal of surgical pathology 2007;31(1):85-94.
2006: Hiromitsu Hatakeyama; Tadashi Kondo; Kiyonaga Fujii; Yukihiro Nakanishi; Hoichi Kato; Satoshi Fukuda; Setsuo Hirohashi
Protein clusters associated with carcinogenesis, histological differentiation and nodal metastasis in esophageal cancer.
Proteomics 2006;6(23):6300-16.
2006: Hiroto Katoh; Tatsuhiro Shibata; Akiko Kokubu; Hidenori Ojima; Tomoo Kosuge; Yae Kanai; Setsuo Hirohashi
Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report.
Genes, chromosomes & cancer 2006;45(11):1050-7.
2006: Hisashi Takada; Issei Imoto; Hitoshi Tsuda; Y Nakanishi; C Sakakura; Shoji Mitsufuji; Setsuo Hirohashi; Johji Inazawa
Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis.
Oncogene 2006;25(49):6554-62.
2006: Nobuyoshi Hiraoka; Kaoru Onozato; Tomoo Kosuge; Setsuo Hirohashi
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5423-34.
2006: Rie Shibata; Taisuke Mori; Wenlin Du; Makoto Chuma; Masahiro Gotoh; Motohide Shimazu; Masakazu Ueda; Setsuo Hirohashi; Michiie Sakamoto
Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5363-8.
2006: Kazuyasu Fujii; Tadashi Kondo; Masayo Yamada; Keiji Iwatsuki; Setsuo Hirohashi
Toward a comprehensive quantitative proteome database: protein expression map of lymphoid neoplasms by 2-D DIGE and MS.
Proteomics 2006;6(17):4856-76.
2006: Yoshiyuki Suehara; Tadashi Kondo; Kiyonaga Fujii; Tadashi Hasegawa; Akira Kawai; Kunihiko Seki; Yasuo Beppu; Toshihide Nishimura; Hisashi Kurosawa; Setsuo Hirohashi
Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas.
Proteomics 2006;6(15):4402-9.
2006: Jeong-Seok Nam; Mi-Jin Kang; Adam M Suchar; Takeshi Shimamura; Ethan A Kohn; Aleksandra M Michalowska; V Craig Jordan; Setsuo Hirohashi; Lalage M Wakefield
Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells.
Cancer research 2006;66(14):7176-84.
2006: Eri Arai; Yae Kanai; Saori Ushijima; Hiroyuki Fujimoto; Kiyoshi Mukai; Setsuo Hirohashi
Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues.
International journal of cancer. Journal international du cancer 2006;119(2):288-96.
2006: Tatsuhiro Shibata; Setsuo Hirohashi
[E-cadherin cell adhesion system in human cancer].
Seikagaku. The Journal of Japanese Biochemical Society 2006;78(7):647-56.
2006: Tetsuya Okano; Tadashi Kondo; Tatsuhiko Kakisaka; Kiyonaga Fujii; Masayo Yamada; Harubumi Kato; Toshihide Nishimura; Akihiko Gemma; Shoji Kudoh; Setsuo Hirohashi
Plasma proteomics of lung cancer by a linkage of multi-dimensional liquid chromatography and two-dimensional difference gel electrophoresis.
Proteomics 2006;6(13):3938-48.
2006: Masaya Ono; Miki Shitashige; Kazufumi Honda; Tomohiro Isobe; Hideya Kuwabara; Hirotaka Matsuzuki; Setsuo Hirohashi; Tesshi Yamada
Label-free quantitative proteomics using large peptide data sets generated by nanoflow liquid chromatography and mass spectrometry.
Molecular & cellular proteomics : MCP 2006;5(7):1338-47.
2006: Anna Batistatou; Alexander K Charalabopoulos; Chrisoula D Scopa; Yukihiro Nakanishi; Angelos M Kappas; Setsuo Hirohashi; Niki J Agnantis; Konstantinos Charalabopoulos
Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma.
Virchows Archiv : an international journal of pathology 2006;448(6):763-7.
2006: Dunfa Peng; Yae Kanai; Morio Sawada; Saori Ushijima; Nobuyoshi Hiraoka; Sohei Kitazawa; Setsuo Hirohashi
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.
Carcinogenesis 2006;27(6):1160-8.
2006: Issei Imoto; Hiroyuki Izumi; Sana Yokoi; Hiroshi Hosoda; Tatsuhiro Shibata; Fumie Hosoda; Misao Ohki; Setsuo Hirohashi; Johji Inazawa
Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers.
Cancer research 2006;66(9):4617-26.
2006: Yu Takahashi; Nobuyoshi Hiraoka; Kaoru Onozato; Tatsuhiro Shibata; Tomoo Kosuge; Yuji Nimura; Yae Kanai; Setsuo Hirohashi
Solid-pseudopapillary neoplasms of the pancreas in men and women: do they differ?
Virchows Archiv : an international journal of pathology 2006;448(5):561-9.
2006: Norimasa Koide; Taketo Yamada; Rie Shibata; Taisuke Mori; Mariko Fukuma; Ken Yamazaki; Koichi Aiura; Motohide Shimazu; Setsuo Hirohashi; Yuji Nimura; Michiie Sakamoto
Establishment of perineural invasion models and analysis of gene expression revealed an invariant chain (CD74) as a possible molecule involved in perineural invasion in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2419-26.
2006: Hiroto Katoh; Tatsuhiro Shibata; Akiko Kokubu; Hidenori Ojima; Masashi Fukayama; Yae Kanai; Setsuo Hirohashi
Epigenetic instability and chromosomal instability in hepatocellular carcinoma.
The American journal of pathology 2006;168(4):1375-84.
2006: Kazuyasu Fujii; Tadashi Kondo; Hideki Yokoo; Tetsuya Okano; Masayo Yamada; Tesshi Yamada; Keiji Iwatsuki; Setsuo Hirohashi
Database of two-dimensional polyacrylamide gel electrophoresis of proteins labeled with CyDye DIGE Fluor saturation dye.
Proteomics 2006;6(5):1640-53.
2006: Panayiotis A Kyzas; Dimitrios Stefanou; Anna Batistatou; Niki J Agnantis; Yukihiro Nakanishi; Setsuo Hirohashi; Konstantinos Charalabopoulos
Dysadherin expression in head and neck squamous cell carcinoma: association with lymphangiogenesis and prognostic significance.
The American journal of surgical pathology 2006;30(2):185-93.
2006: Tadashi Kondo; Setsuo Hirohashi
Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics.
Nature protocols 2006;1(6):2940-56.
2005: Anna Batistatou; Chrisoula D Scopa; Panagiota Ravazoula; Y Nakanishi; Dimitrios Peschos; Niki J Agnantis; Setsuo Hirohashi; Konstantinos Charalabopoulos
Involvement of dysadherin and E-cadherin in the development of testicular tumours.
British journal of cancer 2005;93(12):1382-7.
2005: Hisashi Takada; Issei Imoto; Hitoshi Tsuda; Yukihiro Nakanishi; Takashi Ichikura; Hidetaka Mochizuki; Shoji Mitsufuji; Fumie Hosoda; Setsuo Hirohashi; Misao Ohki; Johji Inazawa
ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.
Oncogene 2005;24(54):8051-60.
2005: Yasuharu Hayashida; Kazufumi Honda; Yoshiaki Osaka; Tomohiko Hara; Tomoko Umaki; Akihiko Tsuchida; Tatsuya Aoki; Setsuo Hirohashi; Tesshi Yamada
Possible prediction of chemoradiosensitivity of esophageal cancer by serum protein profiling.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(22):8042-7.
2005: Kazufumi Honda; Yasuharu Hayashida; Tomoko Umaki; Takuji Okusaka; Tomoo Kosuge; Satoru Kikuchi; Mitsufumi Endo; Akihiko Tsuchida; Tatsuya Aoki; Takao Itoi; Fuminori Moriyasu; Setsuo Hirohashi; Tesshi Yamada
Possible detection of pancreatic cancer by plasma protein profiling.
Cancer research 2005;65(22):10613-22.
2005: Kazuyasu Fujii; Tadashi Kondo; Hideki Yokoo; Tesshi Yamada; Yoshihiro Matsuno; Keiji Iwatsuki; Setsuo Hirohashi
Protein expression pattern distinguishes different lymphoid neoplasms.
Proteomics 2005;5(16):4274-86.
2005: Hiroto Katoh; Tatsuhiro Shibata; Akiko Kokubu; Hidenori Ojima; Panayiotis Loukopoulos; Yae Kanai; Tomoo Kosuge; Masashi Fukayama; Tadashi Kondo; Michiie Sakamoto; Fumie Hosoda; Misao Ohki; Issei Imoto; Johji Inazawa; Setsuo Hirohashi
Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome.
Journal of hepatology 2005;43(5):863-74.
2005: Wei-Xia Peng; Tatsuhiro Shibata; Hiroto Katoh; Akiko Kokubu; Yoshihiro Matsuno; Hisao Asamura; Ryosuke Tsuchiya; Yae Kanai; Fumie Hosoda; Tokuki Sakiyama; Misao Ohki; Issei Imoto; Johji Inazawa; Setsuo Hirohashi
Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung.
Cancer science 2005;96(10):661-7.
2005: Satoshi Sato; Masashi Idogawa; Kazufumi Honda; Gen Fujii; Hisashi Kawashima; Kouji Takekuma; Akinori Hoshika; Setsuo Hirohashi; Tesshi Yamada
Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.
Gastroenterology 2005;129(4):1225-36.
2005: Yasuharu Hayashida; Kazufumi Honda; Masashi Idogawa; Yoshinori Ino; Masaya Ono; Akihiko Tsuchida; Tatsuya Aoki; Setsuo Hirohashi; Tesshi Yamada
E-cadherin regulates the association between beta-catenin and actinin-4.
Cancer research 2005;65(19):8836-45.
2005: Tomohiko Hara; Kazufumi Honda; Masaya Ono; Katsusuke Naito; Setsuo Hirohashi; Tesshi Yamada
Identification of 2 serum biomarkers of renal cell carcinoma by surface enhanced laser desorption/ionization mass spectrometry.
The Journal of urology 2005;174(4 Pt 1):1213-7.
2005: Yukihiro Yoshida; Tatsuhiro Shibata; Akiko Kokubu; Koji Tsuta; Yoshihiro Matsuno; Yae Kanai; Hisao Asamura; Ryosuke Tsuchiya; Setsuo Hirohashi
Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.
Lung cancer (Amsterdam, Netherlands) 2005;50(1):1-8.
2005: Yasuharu Mori; Tadashi Kondo; Tesshi Yamada; Akihiko Tsuchida; Tetsuya Aoki; Setsuo Hirohashi
Two-dimensional electrophoresis database of fluorescence-labeled proteins of colon cancer cells.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;823(2):82-97.
2005: Tatsuhiro Shibata; Satomi Uryu; Akiko Kokubu; Fumie Hosoda; Misao Ohki; Tokuki Sakiyama; Yoshihiro Matsuno; Ryosuke Tsuchiya; Yae Kanai; Tadashi Kondo; Issei Imoto; Johji Inazawa; Setsuo Hirohashi
Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6177-85.
2005: Dunfa Peng; Yae Kanai; Morio Sawada; Saori Ushijima; Nobuyoshi Hiraoka; Tomoo Kosuge; Setsuo Hirohashi
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Cancer science 2005;96(7):403-8.
2005: Masahiro Seike; Tadashi Kondo; Kazuyasu Fujii; Tetsuya Okano; Tesshi Yamada; Yoshihiro Matsuno; Akihiko Gemma; Shoji Kudoh; Setsuo Hirohashi
Proteomic signatures for histological types of lung cancer.
Proteomics 2005;5(11):2939-48.
2005: Yoshitomo Chihara; Kokichi Sugano; Ayumi Kobayashi; Yae Kanai; Hidenobu Yamamoto; Masaaki Nakazono; Hiroyuki Fujimoto; Tadao Kakizoe; Kiyohide Fujimoto; Setsuo Hirohashi; Yoshihiko Hirao
Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene.
Laboratory investigation; a journal of technical methods and pathology 2005;85(7):895-907.
2005: Hitoshi Tsuda; Yoichi Tani; Joel Weisenberger; Shigehiro Kitada; Tadashi Hasegawa; Tetsuya Murata; Seiichi Tamai; Setsuo Hirohashi; Osamu Matsubara; Tsuneo Natori
Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features.
Cancer science 2005;96(6):333-9.
2005: Kazuyoshi Yanagihara; Misato Takigahira; Hiromi Tanaka; Teruo Komatsu; Hisao Fukumoto; Fumiaki Koizumi; Kazuto Nishio; Takahiro Ochiya; Yoshinori Ino; Setsuo Hirohashi
Development and biological analysis of peritoneal metastasis mouse models for human scirrhous stomach cancer.
Cancer science 2005;96(6):323-32.
2005: Masashi Idogawa; Tesshi Yamada; Kazufumi Honda; Satoshi Sato; Kohzoh Imai; Setsuo Hirohashi
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.
Gastroenterology 2005;128(7):1919-36.
2005: Tohru Nakagawa; Yae Kanai; Saori Ushijima; Tadaichi Kitamura; Tadao Kakizoe; Setsuo Hirohashi
DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis.
The Journal of urology 2005;173(5):1767-71.
2005: Yasuyoshi Naishiro; Tesshi Yamada; Masashi Idogawa; Kazufumi Honda; Mizuho Takada; Tadashi Kondo; Kohzoh Imai; Setsuo Hirohashi
Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein.
Oncogene 2005;24(19):3141-53.
2005: Aya Nishizawa; Yukihiro Nakanishi; Kimio Yoshimura; Yuko Sasajima; Naoya Yamazaki; Akifumi Yamamoto; Katsumi Hanada; Yae Kanai; Setsuo Hirohashi
Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients.
Cancer 2005;103(8):1693-700.
2005: Hiroyuki Izumi; Jun-Ichiro Inoue; Sana Yokoi; Hiroshi Hosoda; Tatsuhiro Shibata; Makoto Sunamori; Setsuo Hirohashi; Johji Inazawa; Issei Imoto
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Human molecular genetics 2005;14(8):997-1007.
2005: Nobuhiro Nitori; Yoshinori Ino; Yukihiro Nakanishi; Tesshi Yamada; Kazufumi Honda; Kazuyoshi Yanagihara; Tomoo Kosuge; Yae Kanai; Masaki Kitajima; Setsuo Hirohashi
Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(7):2531-9.
2005: Kazuyasu Fujii; Tadashi Kondo; Hideki Yokoo; Tesshi Yamada; Keiji Iwatsuki; Setsuo Hirohashi
Proteomic study of human hepatocellular carcinoma using two-dimensional difference gel electrophoresis with saturation cysteine dye.
Proteomics 2005;5(5):1411-22.
2005: Takuichi Oikawa; Hidenori Ojima; Susumu Yamasaki; Tadatoshi Takayama; Setsuo Hirohashi; Michiie Sakamoto
Multistep and multicentric development of hepatocellular carcinoma: histological analysis of 980 resected nodules.
Journal of hepatology 2005;42(2):225-9.
2005: Kazuaki Nakanishi; Michiie Sakamoto; Susumu Yamasaki; Satoru Todo; Setsuo Hirohashi
Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma.
Cancer 2005;103(2):307-12.
2005: Kazufumi Honda; Tesshi Yamada; Yasuharu Hayashida; Masashi Idogawa; Satoshi Sato; Fumio Hasegawa; Yoshinori Ino; Masaya Ono; Setsuo Hirohashi
Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer.
Gastroenterology 2005;128(1):51-62.
2005: Tohru Nakagawa; Yae Kanai; Saori Ushijima; Tadaichi Kitamura; Tadao Kakizoe; Setsuo Hirohashi
DNA hypomethylation on pericentromeric satellite regions significantly correlates with loss of heterozygosity on chromosome 9 in urothelial carcinomas.
The Journal of urology 2005;173(1):243-6.
2004: Shigeki Sekine; T Takata; Tatsuhiro Shibata; M Mori; Y Morishita; M Noguchi; T Uchida; Yae Kanai; Setsuo Hirohashi
Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation.
Histopathology 2004;45(6):573-9.
2004: Yukihiro Nakanishi; Shingo Akimoto; Yasuto Sato; Yae Kanai; Michiie Sakamoto; Setsuo Hirohashi
Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2004;12(4):323-8.
2004: Shigeki Sekine; Tadakazu Shimoda; Satoshi Nimura; Yukihiro Nakanishi; Takayuki Akasu; Hitoshi Katai; Takuji Gotoda; Tatsuhiro Shibata; Michiie Sakamoto; Setsuo Hirohashi
High-grade dysplasia associated with fundic gland polyposis in a familial adenomatous polyposis patient, with special reference to APC mutation profiles.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2004;17(11):1421-6.
2004: Yae Kanai; Yoshimasa Saito; Saori Ushijima; Setsuo Hirohashi
Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis.
Journal of cancer research and clinical oncology 2004;130(11):636-44.
2004: Takeshi Shimamura; Jun Yasuda; Yoshinori Ino; Masahiro Gotoh; Akira Tsuchiya; Atsushi Nakajima; Michiie Sakamoto; Yae Kanai; Setsuo Hirohashi
Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells.
Cancer research 2004;64(19):6989-95.
2004: Makoto Chuma; Michiie Sakamoto; Jun Yasuda; Gen Fujii; Kazuaki Nakanishi; Akira Tsuchiya; Tsutomu Ohta; Masahiro Asaka; Setsuo Hirohashi
Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.
Journal of hepatology 2004;41(4):629-36.
2004: Panayiotis Loukopoulos; Kengo Kanetaka; Masaaki Takamura; Tatsuhiro Shibata; Michiie Sakamoto; Setsuo Hirohashi
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Pancreas 2004;29(3):193-203.
2004: Shingo Akimoto; Yukihiro Nakanishi; Michiie Sakamoto; Yae Kanai; Setsuo Hirohashi
Laminin 5 beta3 and gamma2 chains are frequently coexpressed in cancer cells.
Pathology international 2004;54(9):688-92.
2004: Masahiro Seike; Tadashi Kondo; Kazuyasu Fujii; Tesshi Yamada; Akihiko Gemma; Shoji Kudoh; Setsuo Hirohashi
Proteomic signature of human cancer cells.
Proteomics 2004;4(9):2776-88.
2004: Hideki Yokoo; Tadashi Kondo; Kazuyasu Fujii; Tesshi Yamada; Satoru Todo; Setsuo Hirohashi
Proteomic signature corresponding to alpha fetoprotein expression in liver cancer cells.
Hepatology (Baltimore, Md.) 2004;40(3):609-17.
2004: Masaaki Takamura; Takafumi Ichida; Yasunobu Matsuda; Masaaki Kobayashi; Satoshi Yamagiwa; Takuya Genda; Kazuhiko Shioji; Satoru Hashimoto; Minoru Nomoto; Katsuyoshi Hatakeyama; Yoichi Ajioka; Michiie Sakamoto; Setsuo Hirohashi; Yutaka Aoyagi
Reduced expression of liver-intestine cadherin is associated with progression and lymph node metastasis of human colorectal carcinoma.
Cancer letters 2004;212(2):253-9.
2004: Yasumitsu Takagi; Motoyoshi Nomizu; Kumiko Ui-Tei; Naoko Tokushige; Setsuo Hirohashi
Active sites in the carboxyl-terminal region of the laminin alpha chain in Drosophila neuronal cell spreading.
Archives of insect biochemistry and physiology 2004;56(4):162-9.
2004: Kazuyoshi Yanagihara; Hiromi Tanaka; Misato Takigahira; Yoshinori Ino; Yoshiyuki Yamaguchi; Tetsuya Toge; Kokichi Sugano; Setsuo Hirohashi
Establishment of two cell lines from human gastric scirrhous carcinoma that possess the potential to metastasize spontaneously in nude mice.
Cancer science 2004;95(7):575-82.
2004: Meijin Nakayama; Yu-ichi Sato; Makito Okamoto; Setsuo Hirohashi
Increased expression of laminin-5 and its prognostic significance in hypopharyngeal cancer.
The Laryngoscope 2004;114(7):1259-63.
2004: Kazufumi Honda; Tesshi Yamada; Masahiro Seike; Yasuharu Hayashida; Masashi Idogawa; Tadashi Kondo; Yoshinori Ino; Setsuo Hirohashi
Alternative splice variant of actinin-4 in small cell lung cancer.
Oncogene 2004;23(30):5257-62.
2004: Makoto Chuma; Norihisa Saeki; Yoshiya Yamamoto; Tsutomu Ohta; Masahiro Asaka; Setsuo Hirohashi; Michiie Sakamoto
Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis.
The Keio journal of medicine 2004;53(2):90-7.
2004: Itaru Sonoda; Issei Imoto; Jun-Ichiro Inoue; Tatsuhiro Shibata; Yutaka Shimada; Koei Chin; Masayuki Imamura; Teruo Amagasa; Joe Gray; Setsuo Hirohashi; Johji Inazawa
Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
Cancer research 2004;64(11):3741-7.
2004: Tatsuhiro Shibata; Akiko Kokubu; Shigeki Sekine; Yae Kanai; Setsuo Hirohashi
Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer.
The American journal of pathology 2004;164(6):2269-78.
2004: Yutaka Shimada; Seiji Yamasaki; Yosuke Hashimoto; Tetsuo Ito; Junichiro Kawamura; Toshiya Soma; Yoshinori Ino; Yukihiro Nakanishi; Michiie Sakamoto; Setsuo Hirohashi; Masayuki Imamura
Clinical significance of dysadherin expression in gastric cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(8):2818-23.
2004: Wataru Yasui; Setsuo Hirohashi; Kohzoh Imai; Eiichi Tahara
New approaches to identification of biomarkers for early cancer detection: The Thirteenth International Symposium of the Hiroshima Cancer Seminar, October 2003.
Cancer science 2004;95(2):193-5.
2004: Tsuyoshi Etoh; Yae Kanai; Saori Ushijima; Tohru Nakagawa; Yukihiro Nakanishi; Mitsuru Sasako; Seigo Kitano; Setsuo Hirohashi
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
The American journal of pathology 2004;164(2):689-99.
2004: Yutaka Shimada; Yosuke Hashimoto; Takatsugu Kan; Junichiro Kawamura; Tomoyuki Okumura; Toshiya Soma; Kan Kondo; Naoki Teratani; Go Watanabe; Yoshinori Ino; Michiie Sakamoto; Setsuo Hirohashi; Masayuki Imamura
Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma.
Oncology 2004;67(1):73-80.
2004: Yoichi Yamada; Naoki Itano; Hisashi Narimatsu; Takashi Kudo; Kyoei Morozumi; Setsuo Hirohashi; Atsushi Ochiai; Minoru Ueda; Koji Kimata
Elevated transcript level of hyaluronan synthase1 gene correlates with poor prognosis of human colon cancer.
Clinical & experimental metastasis 2004;21(1):57-63.
2004: Jeong-Seok Nam; Yoshinori Ino; Yae Kanai; Michiie Sakamoto; Setsuo Hirohashi
5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis.
Clinical & experimental metastasis 2004;21(1):49-56.
2003: Tohru Nakagawa; Yae Kanai; Yoshimasa Saito; Tadaichi Kitamura; Tadao Kakizoe; Setsuo Hirohashi
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
The Journal of urology 2003;170(6 Pt 1):2463-6.
2003: Akira Tsuchiya; Michiie Sakamoto; Jun Yasuda; Makoto Chuma; Tsutomu Ohta; Misao Ohki; Toshiharu Yasugi; Yuji Taketani; Setsuo Hirohashi
Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma.
The American journal of pathology 2003;163(6):2503-12.
2003: Shigeki Sekine; Sunao Sato; Takashi Takata; Yasuo Fukuda; Takeshi Ishida; Mitsunobu Kishino; Tatsuhiro Shibata; Yae Kanai; Setsuo Hirohashi
Beta-catenin mutations are frequent in calcifying odontogenic cysts, but rare in ameloblastomas.
The American journal of pathology 2003;163(5):1707-12.
2003: Kengo Kanetaka; Michiie Sakamoto; Yoshiya Yamamoto; Masaaki Takamura; Takashi Kanematsu; Setsuo Hirohashi
Possible involvement of tetraspanin CO-029 in hematogenous intrahepatic metastasis of liver cancer cells.
Journal of gastroenterology and hepatology 2003;18(11):1309-14.
2003: Yoichi Yamada; Naoki Itano; Hisashi Narimatsu; Takashi Kudo; Setsuo Hirohashi; Atsushi Ochiai; Iwai Tohnai; Minoru Ueda; Koji Kimata
CD44 variant exon 6 expressions in colon cancer assessed by quantitative analysis using real time reverse transcriptase-polymerase chain reaction.
Oncology reports 2003;10(6):1919-24.
2003: Tadashi Kondo; Masahiro Seike; Yasuharu Mori; Kazuyasu Fujii; Tesshi Yamada; Setsuo Hirohashi
Application of sensitive fluorescent dyes in linkage of laser microdissection and two-dimensional gel electrophoresis as a cancer proteomic study tool.
Proteomics 2003;3(9):1758-66.
2003: Haruhiro Sato; Yoshinori Ino; Ayaka Miura; Yoshifumi Abe; Hideto Sakai; Koichi Ito; Setsuo Hirohashi
Dysadherin: expression and clinical significance in thyroid carcinoma.
The Journal of clinical endocrinology and metabolism 2003;88(9):4407-12.
2003: Jun Yasuda; Akira Tsuchiya; Tesshi Yamada; Michiie Sakamoto; Takao Sekiya; Setsuo Hirohashi
Nemo-like kinase induces apoptosis in DLD-1 human colon cancer cells.
Biochemical and biophysical research communications 2003;308(2):227-33.
2003: Masahiro Seike; Tadashi Kondo; Yasuharu Mori; Akihiko Gemma; Shoji Kudoh; Michiie Sakamoto; Tesshi Yamada; Setsuo Hirohashi
Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin.
Cancer research 2003;63(15):4641-7.
2003: Setsuo Hirohashi; Yae Kanai
Cell adhesion system and human cancer morphogenesis.
Cancer science 2003;94(7):575-81.
2003: Tatsuhiro Shibata; Makoto Chuma; Akiko Kokubu; Michiie Sakamoto; Setsuo Hirohashi
EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2003;38(1):178-86.
2003: Hiroshi Terasaki; Toshiro Niki; Yoshihiro Matsuno; Tesshi Yamada; Arafumi Maeshima; Hisao Asamura; Naofumi Hayabuchi; Setsuo Hirohashi
Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization.
The American journal of surgical pathology 2003;27(7):937-51.
2003: Yoshimasa Saito; Yae Kanai; Tohru Nakagawa; Michiie Sakamoto; Hidetsugu Saito; Hiromasa Ishii; Setsuo Hirohashi
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
International journal of cancer. Journal international du cancer 2003;105(4):527-32.
2003: Hitomi Tsuiji; Seiichi Takasaki; Michiie Sakamoto; Tatsuro Irimura; Setsuo Hirohashi
Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion.
Glycobiology 2003;13(7):521-7.
2003: Shigeki Sekine; Tatsuhiro Shibata; Yoshihiro Matsuno; Arafumi Maeshima; Genichiro Ishii; Michiie Sakamoto; Setsuo Hirohashi
Beta-catenin mutations in pulmonary blastomas: association with morule formation.
The Journal of pathology 2003;200(2):214-21.
2003: Akinobu Yoshimura; Akihiko Gemma; Yoko Hosoya; Eriko Komaki; Yukio Hosomi; Tetsuya Okano; Kiyosi Takenaka; Kuniko Matuda; Masahiro Seike; Kazutsugu Uematsu; Suguru Hibino; Masahiko Shibuya; Tesshi Yamada; Setsuo Hirohashi; Shoji Kudoh
Increased expression of the LGALS3 (galectin 3) gene in human non-small-cell lung cancer.
Genes, chromosomes & cancer 2003;37(2):159-64.
2003: Masaaki Takamura; Michiie Sakamoto; Yoshinori Ino; Takeshi Shimamura; Takafumi Ichida; Hitoshi Asakura; Setsuo Hirohashi
Expression of liver-intestine cadherin and its possible interaction with galectin-3 in ductal adenocarcinoma of the pancreas.
Cancer science 2003;94(5):425-30.
2003: Yohei Horikawa; Kokichi Sugano; Masanori Shigyo; Hidenobu Yamamoto; Masaaki Nakazono; Hiroyuki Fujimoto; Yae Kanai; Setsuo Hirohashi; Tadao Kakizoe; Tomonori Habuchi; Tetsuro Kato
Hypermethylation of an E-cadherin (CDH1) promoter region in high grade transitional cell carcinoma of the bladder comprising carcinoma in situ.
The Journal of urology 2003;169(4):1541-5.
2003: Yae Kanai; Saori Ushijima; Yukihiro Nakanishi; Michiie Sakamoto; Setsuo Hirohashi
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Cancer letters 2003;192(1):75-82.
2003: S Aoki; T Shimamura; T Shibata; Y Nakanishi; Y Moriya; Y Sato; M Kitajima; M Sakamoto; Setsuo Hirohashi
Prognostic significance of dysadherin expression in advanced colorectal carcinoma.
British journal of cancer 2003;88(5):726-32.
2003: Tesshi Yamada; Yasuharu Mori; Reiko Hayashi; Mizuho Takada; Yoshinori Ino; Yasuyoshi Naishiro; Tadashi Kondo; Setsuo Hirohashi
Suppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice.
Cancer research 2003;63(5):895-901.
2003: Yoshiya Yamamoto; Michiie Sakamoto; Gen Fujii; Hitomi Tsuiji; Kengo Kenetaka; Masahiro Asaka; Setsuo Hirohashi
Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations.
Hepatology (Baltimore, Md.) 2003;37(3):528-33.
2003: Takeshi Shimamura; Michiie Sakamoto; Yoshinori Ino; Yasuto Sato; Kazuaki Shimada; Tomoo Kosuge; Hisahiko Sekihara; Setsuo Hirohashi
Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to e-cadherin expression.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(4):659-67.
2003: Ken Yamazaki; Michiie Sakamoto; Tsutomu Ohta; Yae Kanai; Misao Ohki; Setsuo Hirohashi
Overexpression of KIT in chromophobe renal cell carcinoma.
Oncogene 2003;22(6):847-52.
2003: Makoto Chuma; Michiie Sakamoto; Ken Yamazaki; Tsutomu Ohta; Misao Ohki; Masahiro Asaka; Setsuo Hirohashi
Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2003;37(1):198-207.
2002: Shigeki Sekine; Tatsuhiro Shibata; Akiko Kokubu; Yukio Morishita; Masayuki Noguchi; Yukihiro Nakanishi; Michiie Sakamoto; Setsuo Hirohashi
Craniopharyngiomas of adamantinomatous type harbor beta-catenin gene mutations.
The American journal of pathology 2002;161(6):1997-2001.
2002: Seishi Aoki; Yukihiro Nakanishi; Shingo Akimoto; Yoshihiro Moriya; Kimio Yoshimura; Masaki Kitajima; Michiie Sakamoto; Setsuo Hirohashi
Prognostic significance of laminin-5 gamma2 chain expression in colorectal carcinoma: immunohistochemical analysis of 103 cases.
Diseases of the colon and rectum 2002;45(11):1520-7.
2002: Shiro Koizume; Ken Tachibana; Takao Sekiya; Setsuo Hirohashi; Masahiko Shiraishi
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.
Nucleic acids research 2002;30(21):4770-80.
2002: Jeong-Seok Nam; Yoshinori Ino; Michiie Sakamoto; Setsuo Hirohashi
Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.
Japanese journal of cancer research : Gann 2002;93(9):1020-8.
2002: Hitoshi Tsuda; Teruko Takarabe; Yae Kanai; Takashi Fukutomi; Setsuo Hirohashi
Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas.
The American journal of pathology 2002;161(3):859-66.
2002: Issei Imoto; Hitoshi Tsuda; Akira Hirasawa; Masahiko Miura; Masaru Sakamoto; Setsuo Hirohashi; Johji Inazawa
Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy.
Cancer research 2002;62(17):4860-6.
2002: Shigeki Sekine; Tatsuhiro Shibata; Michiie Sakamoto; Setsuo Hirohashi
Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotype.
Oncogene 2002;21(38):5906-11.
2002: Tadashi Hasegawa; Seiichiro Yamamoto; Ryohei Yokoyama; Toru Umeda; Yoshihiro Matsuno; Setsuo Hirohashi
Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk.
Cancer 2002;95(4):843-51.
2002: Makoto Kubo; Michiie Sakamoto; Noriyoshi Fukushima; Shinichi Yachida; Yukihiro Nakanishi; Tadakazu Shimoda; Junji Yamamoto; Yoshihiro Moriya; Setsuo Hirohashi
Less aggressive features of colorectal cancer with liver metastases showing macroscopic intrabiliary extension.
Pathology international 2002;52(8):514-8.
2002: Takeshi Shimamura; Michiie Sakamoto; Yoshinori Ino; Kazuaki Shimada; Tomoo Kosuge; Yasuto Sato; Katsuaki Tanaka; Hisahiko Sekihara; Setsuo Hirohashi
Clinicopathological significance of galectin-3 expression in ductal adenocarcinoma of the pancreas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(8):2570-5.
2002: Yoshimasa Saito; Yae Kanai; Michiie Sakamoto; Hidetsugu Saito; Hiromasa Ishii; Setsuo Hirohashi
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10060-5.
2002: Satoshi Okada; Hitoshi Tsuda; Teruko Takarabe; Hiroyuki Yoshikawa; Yuji Taketani; Setsuo Hirohashi
Allelotype analysis of common epithelial ovarian cancers with special reference to comparison between clear cell adenocarcinoma with other histological types.
Japanese journal of cancer research : Gann 2002;93(7):798-806.
2002: Jeong-Seok Nam; Yoshinori Ino; Michiie Sakamoto; Setsuo Hirohashi
Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2430-6.
2002: Sana Yokoi; Kohichiroh Yasui; Fumiko Saito-Ohara; Katsumi Koshikawa; Toshihiko Iizasa; Takehiko Fujisawa; Takeo Terasaki; Akira Horii; Takashi Takahashi; Setsuo Hirohashi; Johji Inazawa
A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.
The American journal of pathology 2002;161(1):207-16.
2002: Margit Fuchs; Peter Hutzler; Ingrid Brunner; Jürgen Schlegel; Jörg Mages; Ute Reuning; Sandra Hapke; Justus Duyster; Setsuo Hirohashi; Takuya Genda; Michiie Sakamoto; Florian Uberall; Heinz Höfler; Karl-Friedrich Becker; Birgit Luber
Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and phosphatidylinositol 3-kinase inhibitors.
Experimental cell research 2002;276(2):129-41.
2002: Tadashi Hasegawa; Yoshihiro Matsuno; Tadakazu Shimoda; Setsuo Hirohashi
Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade.
Human pathology 2002;33(6):669-76.
2002: Arafumi Maeshima; Michiie Sakamoto; Setsuo Hirohashi
Mixed mucinous-type and non-mucinous-type adenocarcinoma of the lung: immunohistochemical examination and K- ras gene mutation.
Virchows Archiv : an international journal of pathology 2002;440(6):598-603.
2002: Kazuaki Nakanishi; Michiie Sakamoto; Jun Yasuda; Masaaki Takamura; Naoya Fujita; Takashi Tsuruo; Satoru Todo; Setsuo Hirohashi
Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer.
Cancer research 2002;62(10):2971-5.
2002: Satoshi Okada; Hitoshi Tsuda; Kazuo Ohmi; Takahiro Kasamatsu; Takuro Yamada; Ryuichiro Tsunematsu; M Sumi; K Tokuuye; H Yoshikawa; Setsuo Hirohashi
Immature glandular features in squamous cell carcinoma of the uterine cervix as an independent indicator of resistance to radiotherapy.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2002;12(3):277-85.
2002: Hitoshi Tsuda; Teruko Takarabe; Satoshi Okada; Hiroshi Uchida; Takahiro Kasamatsu; Takuro Yamada; Ryuichiro Tsunematsu; Kazuo Ohmi; Setsuo Hirohashi
Different pattern of loss of heterozygosity among endocervical-type adenocarcinoma, endometrioid-type adenocarcinoma and adenoma malignum of the uterine cervix.
International journal of cancer. Journal international du cancer 2002;98(5):713-7.
2002: Shigeki Sekine; Tatsuhiro Shibata; Yuko Yamauchi; Yukihiro Nakanishi; Tadakazu Shimoda; Michiie Sakamoto; Setsuo Hirohashi
Beta-catenin mutations in sporadic fundic gland polyps.
Virchows Archiv : an international journal of pathology 2002;440(4):381-6.
2002: Toshiro Niki; Takashi Kohno; Sanae Iba; Yasumitsu Moriya; Yoko Takahashi; Miyuki Saito; Arafumi Maeshima; Tesshi Yamada; Yoshihiro Matsuno; Masashi Fukayama; Jun Yokota; Setsuo Hirohashi
Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas.
The American journal of pathology 2002;160(3):1129-41.
2002: Yukiko Ono; Yukihiro Nakanishi; Masahiro Gotoh; Michiie Sakamoto; Setsuo Hirohashi
Epidermal growth factor receptor gene amplification is correlated with laminin-5 gamma2 chain expression in oral squamous cell carcinoma cell lines.
Cancer letters 2002;175(2):197-204.
2002: Yoshinori Ino; Masahiro Gotoh; Michiie Sakamoto; Kiyomi Tsukagoshi; Setsuo Hirohashi
Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):365-70.
2002: Kazuhide Katoh; Yukihiro Nakanishi; Shingo Akimoto; Kimio Yoshimura; Minoru Takagi; Michiie Sakamoto; Setsuo Hirohashi
Correlation between laminin-5 gamma2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue.
Oncology 2002;62(4):318-26.
2002: Masahiro Gotoh; Michiie Sakamoto; Kengo Kanetaka; Makoto Chuuma; Setsuo Hirohashi
Overexpression of osteopontin in hepatocellular carcinoma.
Pathology international 2002;52(1):19-24.
2001: Yae Kanai; Saori Ushijima; Yoshimasa Saito; Yukihiro Nakanishi; Michiie Sakamoto; Setsuo Hirohashi
MRNA expression of genes altered by 5-azacytidine treatment in cancer cell lines is associated with clinicopathological parameters of human cancers.
Journal of cancer research and clinical oncology 2001;127(12):697-706.
2001: Kengo Kanetaka; Michiie Sakamoto; Yoshiya Yamamoto; S Yamasaki; F Lanza; T Kanematsu; Setsuo Hirohashi
Overexpression of tetraspanin CO-029 in hepatocellular carcinoma.
Journal of hepatology 2001;35(5):637-42.
2001: Teruko Takarabe; Hitoshi Tsuda; Satoshi Okada; Takashi Fukutomi; Setsuo Hirohashi
Detection of numerical alterations of chromosome 1 in cytopathological specimens of breast tumors by chromogen in situ hybridization.
Pathology international 2001;51(10):786-91.
2001: Michiie Sakamoto; Masaaki Takamura; Yoshinori Ino; A Miura; Takuya Genda; Setsuo Hirohashi
Involvement of c-Src in carcinoma cell motility and metastasis.
Japanese journal of cancer research : Gann 2001;92(9):941-6.
2001: N Fukushima; Michiie Sakamoto; K Mukai; Yae Kanai; Kazuaki Shimada; Tomoo Kosuge; Setsuo Hirohashi
Intraductal papillary components in invasive ductal carcinoma of the pancreas are associated with long-term survival of patients.
Human pathology 2001;32(8):834-41.
2001: N Fukushima; K Mukai; Michiie Sakamoto; T Hasebe; Kazuaki Shimada; Tomoo Kosuge; T Kinoshita; Setsuo Hirohashi
Invasive carcinoma derived from intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic and immunohistochemical study of eight cases.
Virchows Archiv : an international journal of pathology 2001;439(1):6-13.
2001: T Hasegawa; Yoshihiro Matsuno; Tadakazu Shimoda; T Umeda; R Yokoyama; Setsuo Hirohashi
Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2001;14(7):655-63.
2001: Hitoshi Tsuda; Teruko Takarabe; Sadako Akashi-Tanaka; Takashi Fukutomi; Setsuo Hirohashi
Pattern of chromosome 16q loss differs between an atypical proliferative lesion and an intraductal or invasive ductal carcinoma occurring subsequently in the same area of the breast.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2001;14(5):382-8.
2001: M Tokunou; Toshiro Niki; K Eguchi; Sanae Iba; Hitoshi Tsuda; Tesshi Yamada; Yoshihiro Matsuno; H Kondo; Y Saitoh; H Imamura; Setsuo Hirohashi
c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma.
The American journal of pathology 2001;158(4):1451-63.
2001: Toshiro Niki; Sanae Iba; Tesshi Yamada; Yoshihiro Matsuno; B Enholm; Setsuo Hirohashi
Expression of vascular endothelial growth factor receptor 3 in blood and lymphatic vessels of lung adenocarcinoma.
The Journal of pathology 2001;193(4):450-7.
2001: Y Naishiro; Tesshi Yamada; A S Takaoka; R Hayashi; F Hasegawa; K Imai; Setsuo Hirohashi
Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation.
Cancer research 2001;61(6):2751-8.
2001: Yukihiro Nakanishi; Atsushi Ochiai; Harubumi Kato; Yuji Tachimori; H Igaki; Setsuo Hirohashi
Clinicopathological significance of tumor nest configuration in patients with esophageal squamous cell carcinoma.
Cancer 2001;91(6):1114-20.
2001: T Hasegawa; R Yokoyama; Yoshihiro Matsuno; T Shimoda; Setsuo Hirohashi
Prognostic significance of histologic grade and nuclear expression of beta-catenin in synovial sarcoma.
Human pathology 2001;32(3):257-63.
2001: Masaaki Takamura; Michiie Sakamoto; Takuya Genda; Takafumi Ichida; Hitoshi Asakura; Setsuo Hirohashi
Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632.
Hepatology (Baltimore, Md.) 2001;33(3):577-81.
2001: Yoshimasa Saito; Yae Kanai; Michiie Sakamoto; Hidetsugu Saito; Hiromasa Ishii; Setsuo Hirohashi
Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2001;33(3):561-8.
2001: Yoshiya Yamamoto; Michiie Sakamoto; G Fujii; Kengo Kanetaka; Masahiro Asaka; Setsuo Hirohashi
Cloning and characterization of a novel gene, DRH1, down-regulated in advanced human hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(2):297-303.
2001: Yae Kanai; Saori Ushijima; Y Kondo; Yukihiro Nakanishi; Setsuo Hirohashi
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
International journal of cancer. Journal international du cancer 2001;91(2):205-12.
2001: H Sato; T Hasegawa; Yae Kanai; Y Tsutsumi; Y Osamura; Y Abe; H Sakai; Setsuo Hirohashi
Expression of cadherins and their undercoat proteins (alpha-, beta-, and gamma-catenins and p120) and accumulation of beta-catenin with no gene mutations in synovial sarcoma.
Virchows Archiv : an international journal of pathology 2001;438(1):23-30.
2000: X Zhu; Yae Kanai; A Saito; Y Kondo; Setsuo Hirohashi
Aberrant expression of beta-catenin and mutation of exon 3 of the beta-catenin gene in renal and urothelial carcinomas.
Pathology international 2000;50(12):945-52.
2000: K Maruyama; A Ochiai; S Akimoto; S Nakamura; S Baba; Y Moriya; Setsuo Hirohashi
Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer.
Oncology 2000;59(4):302-9.
2000: M Tokunou; Toshiro Niki; Y Saitoh; H Imamura; Michiie Sakamoto; Setsuo Hirohashi
Altered expression of the ERM proteins in lung adenocarcinoma.
Laboratory investigation; a journal of technical methods and pathology 2000;80(11):1643-50.
2000: Y Kondo; Yae Kanai; Michiie Sakamoto; M Mizokami; R Ueda; Setsuo Hirohashi
Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2000;32(5):970-9.
2000: T Hasegawa; K Seki; K Ono; Setsuo Hirohashi
Angiomatoid (malignant) fibrous histiocytoma: a peculiar low-grade tumor showing immunophenotypic heterogeneity and ultrastructural variations.
Pathology international 2000;50(9):731-8.
2000: Tesshi Yamada; A S Takaoka; Y Naishiro; R Hayashi; K Maruyama; C Maesawa; Atsushi Ochiai; Setsuo Hirohashi
Transactivation of the multidrug resistance 1 gene by T-cell factor 4/beta-catenin complex in early colorectal carcinogenesis.
Cancer research 2000;60(17):4761-6.
2000: Hitoshi Tsuda; Teruko Takarabe; Takashi Fukutomi; Setsuo Hirohashi
Preferential occurrence of breast carcinomas with loss of chromosome 16q and der (16) t (1;16) / der (1;16) in middle-aged patients with hyperplasia of mammary glands.
Japanese journal of cancer research : Gann 2000;91(7):692-9.
2000: Toshiro Niki; Sanae Iba; M Tokunou; Tesshi Yamada; Yoshihiro Matsuno; Setsuo Hirohashi
Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(6):2431-9.
2000: Y Takagi; Kumiko Ui-Tei; Setsuo Hirohashi
Adhesion-dependent tyrosine phosphorylation of enabled in Drosophila neuronal cell line.
Biochemical and biophysical research communications 2000;270(2):482-7.
2000: Takuya Genda; Michiie Sakamoto; Takafumi Ichida; Hitoshi Asakura; Setsuo Hirohashi
Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells.
Laboratory investigation; a journal of technical methods and pathology 2000;80(3):387-94.
2000: Y Ishii; A Ochiai; T Yamada; S Akimoto; K Yanagihara; M Kitajima; Setsuo Hirohashi
Integrin alpha6beta4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer.
Gastroenterology 2000;118(3):497-506.
2000: Hitoshi Tsuda; Teruko Takarabe; F Hasegawa; Takashi Fukutomi; Setsuo Hirohashi
Large, central acellular zones indicating myoepithelial tumor differentiation in high-grade invasive ductal carcinomas as markers of predisposition to lung and brain metastases.
The American journal of surgical pathology 2000;24(2):197-202.
2000: Y Anami; T Takeuchi; K Mase; Jun Yasuda; Setsuo Hirohashi; M Perucho; M Noguchi
Amplotyping of microdissected, methanol-fixed lung carcinoma by arbitrarily primed polymerase chain reaction.
International journal of cancer. Journal international du cancer 2000;89(1):19-25.
2000: Yae Kanai; Saori Ushijima; Hitoshi Tsuda; Michiie Sakamoto; Setsuo Hirohashi
Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis.
Cancer letters 2000;148(1):73-80.
2000: T Hasegawa; R Yokoyama; Y H Lee; T Shimoda; Y Beppu; Setsuo Hirohashi
Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma.
Oncology 2000;58(1):66-74.
1999: T Hasegawa; Y Matsuno; T Shimoda; F Hasegawa; T Sano; Setsuo Hirohashi
Extrathoracic solitary fibrous tumors: their histological variability and potentially aggressive behavior.
Human pathology 1999;30(12):1464-73.
1999: Y Kondo; Yae Kanai; Michiie Sakamoto; Takuya Genda; M Mizokami; R Ueda; Setsuo Hirohashi
Beta-catenin accumulation and mutation of exon 3 of the beta-catenin gene in hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1999;90(12):1301-9.
1999: Yae Kanai; S Ushijima; Y Nakanishi; Setsuo Hirohashi
Reduced mRNA expression of the DNA demethylase, MBD2, in human colorectal and stomach cancers.
Biochemical and biophysical research communications 1999;264(3):962-6.
1999: H Sato; T Hasegawa; Y Abe; H Sakai; Setsuo Hirohashi
Expression of E-cadherin in bone and soft tissue sarcomas: a possible role in epithelial differentiation.
Human pathology 1999;30(11):1344-9.
1999: Hitoshi Tsuda; Teruko Takarabe; T Hasegawa; T Murata; Setsuo Hirohashi
Myoepithelial differentiation in high-grade invasive ductal carcinomas with large central acellular zones.
Human pathology 1999;30(10):1134-9.
1999: Takuya Genda; Michiie Sakamoto; Takafumi Ichida; Hitoshi Asakura; M Kojiro; S Narumiya; Setsuo Hirohashi
Cell motility mediated by rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 1999;30(4):1027-36.
1999: Fumiaki Masui; Yoshihiro Matsuno; R Yokoyama; Y Nakanishi; T Hasegawa; Yae Kanai; Yasuo Beppu; Setsuo Hirohashi; K Fujii; T Shimoda
Synovial sarcoma, histologically mimicking primitive neuroectodermal tumor/Ewing's sarcoma at distant sites.
Japanese journal of clinical oncology 1999;29(9):438-41.
1999: A Saito; Yae Kanai; C Maesawa; A Ochiai; A Torii; Setsuo Hirohashi
Disruption of E-cadherin-mediated cell adhesion systems in gastric cancers in young patients.
Japanese journal of cancer research : Gann 1999;90(9):993-9.
1999: Yoichi Yamada; Naoki Itano; Hisashi Narimatsu; Takashi Kudo; Setsuo Hirohashi; A Ochiai; A Niimi; Minoru Ueda; Koji Kimata
Receptor for hyaluronan-mediated motility and CD44 expressions in colon cancer assessed by quantitative analysis using real-time reverse transcriptase-polymerase chain reaction.
Japanese journal of cancer research : Gann 1999;90(9):987-92.
1999: Y Kondo; Yae Kanai; Michiie Sakamoto; M Mizokami; R Ueda; Setsuo Hirohashi
Microsatellite instability associated with hepatocarcinogenesis.
Journal of hepatology 1999;31(3):529-36.
1999: Hitoshi Tsuda; Teruko Takarabe; Setsuo Hirohashi
Correlation of numerical and structural status of chromosome 16 with histological type and grade of non-invasive and invasive breast carcinomas.
International journal of cancer. Journal international du cancer 1999;84(4):381-7.
1999: Y Ono; Yukihiro Nakanishi; Y Ino; Toshiro Niki; Tesshi Yamada; Kimio Yoshimura; M Saikawa; T Nakajima; Setsuo Hirohashi
Clinocopathologic significance of laminin-5 gamma2 chain expression in squamous cell carcinoma of the tongue: immunohistochemical analysis of 67 lesions.
Cancer 1999;85(11):2315-21.
1999: Y Shimoyama; H Takeda; S Yoshihara; M Kitajima; Setsuo Hirohashi
Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin.
The Journal of biological chemistry 1999;274(17):11987-94.
1999: Yukihiro Nakanishi; Atsushi Ochiai; T Shimoda; H Yamaguchi; Yuji Tachimori; Harubumi Kato; H Watanabe; Setsuo Hirohashi
Heterotopic sebaceous glands in the esophagus: histopathological and immunohistochemical study of a resected esophagus.
Pathology international 1999;49(4):364-8.
1999: T Harabayashi; Yae Kanai; Tesshi Yamada; M Sakamoto; A Ochiai; Tadao Kakizoe; T Koyanagi; Setsuo Hirohashi
Reduction of integrin beta4 and enhanced migration on laminin in association with intraepithelial spreading of urinary bladder carcinomas.
The Journal of urology 1999;161(4):1364-71.
1999: Yae Kanai; AM Hui; L Sun; Saori Ushijima; Michiie Sakamoto; Hitoshi Tsuda; Setsuo Hirohashi
DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 1999;29(3):703-9.
1999: T Osada; Michiie Sakamoto; H Nagawa; J Yamamoto; Yoshihiro Matsuno; A Iwamatsu; T Muto; Setsuo Hirohashi
Acquisition of glutamine synthetase expression in human hepatocarcinogenesis: relation to disease recurrence and possible regulation by ubiquitin-dependent proteolysis.
Cancer 1999;85(4):819-31.
1999: Hitoshi Tsuda; Teruko Takarabe; Takashi Fukutomi; Setsuo Hirohashi
der(16)t(1;16)/der(1;16) in breast cancer detected by fluorescence in situ hybridization is an indicator of better patient prognosis.
Genes, chromosomes & cancer 1999;24(1):72-7.
1998: A S Takaoka; Tesshi Yamada; M Gotoh; Yae Kanai; K Imai; Setsuo Hirohashi
Cloning and characterization of the human beta4-integrin gene promoter and enhancers.
The Journal of biological chemistry 1998;273(50):33848-55.
1998: A Saito; T Hasegawa; T Shimoda; G Toda; Setsuo Hirohashi; G Tajima; Y Moriya
Dedifferentiated chordoma: a case report.
Japanese journal of clinical oncology 1998;28(12):766-71.
1998: T Hasegawa; Yoshihiro Matsuno; T Niki; Setsuo Hirohashi; T Shimoda; J Takayama; C Watanabe; A Kaneko; T Sano; M Sato; J Suzuki
Second primary rhabdomyosarcomas in patients with bilateral retinoblastoma: a clinicopathologic and immunohistochemical study.
The American journal of surgical pathology 1998;22(11):1351-60.
1998: Tadatoshi Takayama; Makuuchi Masatoshi; Setsuo Hirohashi; Michiie Sakamoto; J Yamamoto; K Shimada; T Kosuge; S Okada; K Takayasu; S Yamasaki
Early hepatocellular carcinoma as an entity with a high rate of surgical cure.
Hepatology (Baltimore, Md.) 1998;28(5):1241-6.
1998: AM Hui; L Sun; Yae Kanai; Michiie Sakamoto; Setsuo Hirohashi
Reduced p27Kip1 expression in hepatocellular carcinomas.
Cancer letters 1998;132(1-2):67-73.
1998: Michiie Sakamoto; Setsuo Hirohashi
Natural history and prognosis of adenomatous hyperplasia and early hepatocellular carcinoma: multi-institutional analysis of 53 nodules followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or percutaneous ethanol injection.
Japanese journal of clinical oncology 1998;28(10):604-8.
1998: T Fukuchi; Michiie Sakamoto; Hitoshi Tsuda; K Maruyama; S Nozawa; Setsuo Hirohashi
Beta-catenin mutation in carcinoma of the uterine endometrium.
Cancer research 1998;58(16):3526-8.
1998: S Akimoto; A Ochiai; M Inomata; Setsuo Hirohashi
Expression of cadherin-catenin cell adhesion molecules, phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers.
Japanese journal of cancer research : Gann 1998;89(8):829-36.
1998: Setsuo Hirohashi
Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.
The American journal of pathology 1998;153(2):333-9.
1998: K Maruyama; Atsushi Ochiai; S Nakamura; S Baba; Setsuo Hirohashi
[Dysfunction of E-cadherin-catenin system in invasion and metastasis of colorectal cancer].
Nihon Geka Gakkai zasshi 1998;99(7):402-8.
1998: Hitoshi Tsuda; Setsuo Hirohashi
Multiple developmental pathways of highly aggressive breast cancers disclosed by comparison of histological grades and c-erbB-2 expression patterns in both the non-invasive and invasive portions.
Pathology international 1998;48(7):518-25.
1998: Yoshihiro Matsuno; N Morozumi; Setsuo Hirohashi; Y Shimosato; J Rosai
Papillary carcinoma of the thymus: report of four cases of a new microscopic type of thymic carcinoma.
The American journal of surgical pathology 1998;22(7):873-80.
1998: T Hasebe; Hitoshi Tsuda; Setsuo Hirohashi; Y Shimosato; Y Tsubono; H Yamamoto; K Mukai
Fibrotic focus in infiltrating ductal carcinoma of the breast: a significant histopathological prognostic parameter for predicting the long-term survival of the patients.
Breast cancer research and treatment 1998;49(3):195-208.
1998: Soichi Sugitani; Michiie Sakamoto; Takafumi Ichida; Takuya Genda; Hitoshi Asakura; Setsuo Hirohashi
Hyperplastic foci reflect the risk of multicentric development of human hepatocellular carcinoma.
Journal of hepatology 1998;28(6):1045-53.
1998: T Hasegawa; T Shimoda; Setsuo Hirohashi; K Hizawa; T Sano
Collagenous fibroma (desmoplastic fibroblastoma): report of four cases and review of the literature.
Archives of pathology & laboratory medicine 1998;122(5):455-60.
1998: Y Shimoyama; T Shibata; M Kitajima; Setsuo Hirohashi
Molecular cloning and characterization of a novel human classic cadherin homologous with mouse muscle cadherin.
The Journal of biological chemistry 1998;273(16):10011-8.
1998: Yukihiro Nakanishi; Atsushi Ochiai; Kimio Yoshimura; Harubumi Kato; T Shimoda; H Yamaguchi; Yuji Tachimori; H Watanabe; Setsuo Hirohashi
The clinicopathologic significance of small areas unstained by Lugol's iodine in the mucosa surrounding resected esophageal carcinoma: an analysis of 147 cases.
Cancer 1998;82(8):1454-9.
1998: H Yoshioka; T Takeuchi; Yoshihiro Matsuno; Tesshi Yamada; Y Shimosato; Setsuo Hirohashi; M Noguchi
Analysis of loss of heterozygosity in small adenocarcinomas of the lung.
Japanese journal of clinical oncology 1998;28(4):240-4.
1998: K Honda; Tesshi Yamada; R Endo; Y Ino; M Gotoh; H Tsuda; Y Yamada; H Chiba; Setsuo Hirohashi
Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion.
The Journal of cell biology 1998;140(6):1383-93.
1998: Hitoshi Tsuda; C Sakamaki; S Tsugane; Takashi Fukutomi; Setsuo Hirohashi
A prospective study of the significance of gene and chromosome alterations as prognostic indicators of breast cancer patients with lymph node metastases.
Breast cancer research and treatment 1998;48(1):21-32.
1998: M Inomata; Atsushi Ochiai; K Sugihara; Y Moriya; N Yamaguchi; Y Adachi; S Kitano; Setsuo Hirohashi
Macroscopic features at the deepest site of tumor penetration predicting liver metastases of colorectal cancer.
Japanese journal of clinical oncology 1998;28(2):123-8.
1998: T Hasegawa; Yoshihiro Matsuno; T Shimoda; Setsuo Hirohashi; T Hirose; T Sano
Frequent expression of bcl-2 protein in solitary fibrous tumors.
Japanese journal of clinical oncology 1998;28(2):86-91.
1998: Yae Kanai; Saori Ushijima; Atsushi Ochiai; K Eguchi; A Hui; Setsuo Hirohashi
DNA hypermethylation at the D17S5 locus is associated with gastric carcinogenesis.
Cancer letters 1998;122(1-2):135-41.
1998: Hitoshi Tsuda; Teruko Takarabe; K Shimamura; Setsuo Hirohashi
Detection of alterations in chromosomes 16 and 1 by fluorescence in situ hybridization in breast tumors cytologically or histologically equivocal for malignancy.
Pathobiology : journal of immunopathology, molecular and cellular biology 1998;66(6):268-73.
1998: Hitoshi Tsuda; C Sakamaki; S Tsugane; Takashi Fukutomi; Setsuo Hirohashi
Prognostic significance of accumulation of gene and chromosome alterations and histological grade in node-negative breast carcinoma.
Japanese journal of clinical oncology 1998;28(1):5-11.
1997: T Yamada; R Endo; Masahiro Gotoh; Setsuo Hirohashi
Identification of semaphorin E as a non-MDR drug resistance gene of human cancers.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14713-8.
1997: L Sun; AM Hui; Yae Kanai; Michiie Sakamoto; Setsuo Hirohashi
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1997;88(12):1165-70.
1997: K Eguchi; Yae Kanai; K Kobayashi; Setsuo Hirohashi
DNA hypermethylation at the D17S5 locus in non-small cell lung cancers: its association with smoking history.
Cancer research 1997;57(21):4913-5.
1997: M Noguchi; S Furuya; T Takeuchi; Setsuo Hirohashi
Modified formalin and methanol fixation methods for molecular biological and morphological analyses.
Pathology international 1997;47(10):685-91.
1997: Hitoshi Tsuda; Teruko Takarabe; N Susumu; Johji Inazawa; Satoshi Okada; Setsuo Hirohashi
Detection of numerical and structural alterations and fusion of chromosomes 16 and 1 in low-grade papillary breast carcinoma by fluorescence in situ hybridization.
The American journal of pathology 1997;151(4):1027-34.
1997: Y Morishita; Hitoshi Tsuda; Takashi Fukutomi; K Mukai; Y Shimosato; Setsuo Hirohashi
Clinicopathological characteristics of primary breast cancer in older geriatric women: a study of 39 Japanese patients over 80 years old.
Japanese journal of cancer research : Gann 1997;88(7):693-9.
1997: T Osada; Michiie Sakamoto; H Nishibori; K Iwaya; Y Matsuno; T Muto; Setsuo Hirohashi
Increased ubiquitin immunoreactivity in hepatocellular carcinomas and precancerous lesions of the liver.
Journal of hepatology 1997;26(6):1266-73.
1997: Yae Kanai; Saori Ushijima; AM Hui; Atsushi Ochiai; Hitoshi Tsuda; Michiie Sakamoto; Setsuo Hirohashi
The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas.
International journal of cancer. Journal international du cancer 1997;71(3):355-9.
1997: Y Nakanishi; A Ochiai; T Shimoda; H Yamaguchi; Y Tachimori; H Kato; H Watanabe; Setsuo Hirohashi
Epidermization in the esophageal mucosa: unusual epithelial changes clearly detected by Lugol's staining.
The American journal of surgical pathology 1997;21(5):605-9.
1997: K Iwaya; H Nishibori; T Osada; Y Matsuno; Hitoshi Tsuda; S Sato; H Kono; Takashi Fukutomi; M Suzuki; C Torikata; A Iwamatsu; Setsuo Hirohashi
Immunoreaction at 43 kDa with anti-ubiquitin antibody in breast neoplasms.
Japanese journal of cancer research : Gann 1997;88(3):273-80.
1997: Y Nakanishi; A Ochiai; S Akimoto; H Kato; H Watanabe; Y Tachimori; S Yamamoto; Setsuo Hirohashi
Expression of E-cadherin, alpha-catenin, beta-catenin and plakoglobin in esophageal carcinomas and its prognostic significance: immunohistochemical analysis of 96 lesions.
Oncology 1997;54(2):158-65.
1997: AM Hui; Yae Kanai; Michiie Sakamoto; Hitoshi Tsuda; Setsuo Hirohashi
Reduced p21(WAF1/CIP1) expression and p53 mutation in hepatocellular carcinomas.
Hepatology (Baltimore, Md.) 1997;25(3):575-9.
1997: CK Lindsay; Unnur P Thorgeirsson; H Tsuda; Setsuo Hirohashi
Expression of tissue inhibitor of metalloproteinase-1 and type IV collagenase/gelatinase messenger RNAs in human breast cancer.
Human pathology 1997;28(3):359-66.
1997: T Shibata; Y Shimoyama; M Gotoh; Setsuo Hirohashi
Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning.
The Journal of biological chemistry 1997;272(8):5236-40.
1997: K Iwaya; Hitoshi Tsuda; Takashi Fukutomi; S Tsugane; M Suzuki; Setsuo Hirohashi
Histologic grade and p53 immunoreaction as indicators of early recurrence of node-negative breast cancer.
Japanese journal of clinical oncology 1997;27(1):6-12.
1997: N Yasui; Michiie Sakamoto; A Ochiai; Y Ino; S Akimoto; A Orikasa; M Kitajima; Setsuo Hirohashi
Tumor growth and metastasis of human colorectal cancer cell lines in SCID mice resemble clinical metastatic behaviors.
Invasion & metastasis 1997;17(5):259-69.
1997: Hitoshi Tsuda; C Sakamaki; Takashi Fukutomi; Setsuo Hirohashi
Squamoid features and expression of involucrin in primary breast carcinoma associated with high histological grade, tumour cell necrosis and recurrence sites.
British journal of cancer 1997;75(10):1519-24.
1996: Yae Kanai; Saori Ushijima; Hitoshi Tsuda; Michiie Sakamoto; T Sugimura; Setsuo Hirohashi
Aberrant DNA methylation on chromosome 16 is an early event in hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1996;87(12):1210-7.
1996: T Osada; Michiie Sakamoto; Y Ino; A Iwamatsu; Y Matsuno; T Muto; Setsuo Hirohashi
E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 1996;24(6):1460-7.
1996: N Ohsawa; Michiie Sakamoto; T Saito; M Kobayashi; Setsuo Hirohashi
Numerical chromosome aberrations in hepatocellular carcinoma detected by fluorescence in situ hybridization.
Journal of hepatology 1996;25(5):655-62.
1996: T Yamada; R Endo; K Tsukagoshi; S Fujita; K Honda; M Kinoshita; T Hasebe; Setsuo Hirohashi
Aberrant expression of a hemidesmosomal protein, bullous pemphigoid antigen 2, in human squamous cell carcinoma.
Laboratory investigation; a journal of technical methods and pathology 1996;75(4):589-600.
1996: M Ono; M Sakamoto; Y Ino; Y Moriya; K Sugihara; T Muto; Setsuo Hirohashi
Cancer cell morphology at the invasive front and expression of cell adhesion-related carbohydrate in the primary lesion of patients with colorectal carcinoma with liver metastasis.
Cancer 1996;78(6):1179-86.
1996: AM Hui; Michiie Sakamoto; Yae Kanai; Y Ino; M Gotoh; J Yokota; Setsuo Hirohashi
Inactivation of p16INK4 in hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 1996;24(3):575-9.
1996: H Muta; M Noguchi; Yae Kanai; Atsushi Ochiai; H Nawata; Setsuo Hirohashi
E-cadherin gene mutations in signet ring cell carcinoma of the stomach.
Japanese journal of cancer research : Gann 1996;87(8):843-8.
1996: Hitoshi Tsuda; C Sakamaki; K Shimamura; Setsuo Hirohashi
Detection of allele loss on chromosome 16q in DNA isolated from fine needle aspiration specimens of breast tumors. A simulation study using surgically resected specimens.
Acta cytologica 1996;40(4):625-30.
1996: H Nishibori; Yoshihiro Matsuno; M Iwaya; T Osada; N Kubomura; A Iwamatsu; H Kohno; S Sato; M Kitajima; Setsuo Hirohashi
Human colorectal carcinomas specifically accumulate Mr 42,000 ubiquitin-conjugated cytokeratin 8 fragments.
Cancer research 1996;56(12):2752-7.
1996: M Inomata; Atsushi Ochiai; S Akimoto; S Kitano; Setsuo Hirohashi
Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients.
Cancer research 1996;56(9):2213-7.
1996: Takahiro Hasebe; Hitoshi Tsuda; Setsuo Hirohashi; Y Shimosato; M Iwai; Shigeru Imoto; K Mukai
Fibrotic focus in invasive ductal carcinoma: an indicator of high tumor aggressiveness.
Japanese journal of cancer research : Gann 1996;87(4):385-94.
1996: J H Cho; M Noguchi; Atsushi Ochiai; Setsuo Hirohashi
Loss of heterozygosity of multiple tumor suppressor genes in human gastric cancers by polymerase chain reaction.
Laboratory investigation; a journal of technical methods and pathology 1996;74(4):835-41.
1996: Atsushi Ochiai; Y Yamauchi; Setsuo Hirohashi
p53 mutations in the non-neoplastic mucosa of the human stomach showing intestinal metaplasia.
International journal of cancer. Journal international du cancer 1996;69(1):28-33.
1996: T Shibata; Atsushi Ochiai; M Gotoh; R Machinami; Setsuo Hirohashi
Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse-type gastric cancer.
Cancer letters 1996;99(2):147-53.
1996: M Sakamoto; Y Ino; Atsushi Ochiai; Y Kanai; S Akimoto; Setsuo Hirohashi
Formation of focal adhesion and spreading of polarized human colon cancer cells in association with tyrosine phosphorylation of paxillin in response to phorbol ester.
Laboratory investigation; a journal of technical methods and pathology 1996;74(1):199-208.
1995: Hitoshi Tsuda; K Jiko; S Tsugane; M Yajima; T Yamada; K Tanemura; R Tsunematsu; Kazuo Ohmi; T Sonoda; Setsuo Hirohashi
Prognostic value of p53 protein accumulation in cancer cell nuclei in adenocarcinoma of the uterine cervix.
Japanese journal of cancer research : Gann 1995;86(11):1049-53.
1995: Hitoshi Tsuda; Setsuo Hirohashi
Identification of multiple breast cancers of multicentric origin by histological observations and distribution of allele loss on chromosome 16q.
Cancer research 1995;55(15):3395-8.
1995: K Yoshiura; Y Kanai; A Ochiai; Y Shimoyama; T Sugimura; Setsuo Hirohashi
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7416-9.
1995: Hitoshi Tsuda; K Jiko; M Yajima; T Yamada; K Tanemura; R Tsunematsu; Kazuo Ohmi; T Sonoda; Setsuo Hirohashi
Frequent occurrence of c-Ki-ras gene mutations in well differentiated endometrial adenocarcinoma showing infiltrative local growth with fibrosing stromal response.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 1995;14(3):255-9.
1995: M Noguchi; A Morikawa; M Kawasaki; Yoshihiro Matsuno; Tesshi Yamada; Setsuo Hirohashi; H Kondo; Y Shimosato
Small adenocarcinoma of the lung. Histologic characteristics and prognosis.
Cancer 1995;75(12):2844-52.
1995: K Iwaya; Hitoshi Tsuda; S Fujita; M Suzuki; Setsuo Hirohashi
Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues.
Laboratory investigation; a journal of technical methods and pathology 1995;72(6):707-14.
1995: Yukihiro Nakanishi; M Noguchi; Yoshihiro Matsuno; M Saikawa; K Mukai; Y Shimosato; Setsuo Hirohashi
p53 expression in multicentric squamous cell carcinoma and surrounding squamous epithelium of the upper aerodigestive tract. Immunohistochemical analysis of 95 lesions.
Cancer 1995;75(7):1657-62.
1995: Yae Kanai; Atsushi Ochiai; T Shibata; T Oyama; Saori Ushijima; S Akimoto; Setsuo Hirohashi
c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.
Biochemical and biophysical research communications 1995;208(3):1067-72.
1995: Y Kanai; Hitoshi Tsuda; T Oda; M Sakamoto; Setsuo Hirohashi
Analysis of the neurofibromatosis 2 gene in human breast and hepatocellular carcinomas.
Japanese journal of clinical oncology 1995;25(1):1-4.
1995: Takahiro Hasebe; M Sakamoto; K Mukai; N Kawano; M Konishi; M Ryu; S Fukamachi; Setsuo Hirohashi
Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma.
Virchows Archiv : an international journal of pathology 1995;426(2):209-13.
1994: K Jiko; Hitoshi Tsuda; S Sato; Setsuo Hirohashi
Pathogenetic significance of p53 and c-Ki-ras gene mutations and human papillomavirus DNA integration in adenocarcinoma of the uterine cervix and uterine isthmus.
International journal of cancer. Journal international du cancer 1994;59(5):601-6.
1994: Atsushi Ochiai; S Akimoto; Yae Kanai; T Shibata; T Oyama; Setsuo Hirohashi
c-erbB-2 gene product associates with catenins in human cancer cells.
Biochemical and biophysical research communications 1994;205(1):73-8.
1994: Hitoshi Tsuda; Y Uei; Takashi Fukutomi; Setsuo Hirohashi
Different incidence of loss of heterozygosity on chromosome 16q between intraductal papilloma and intracystic papillary carcinoma of the breast.
Japanese journal of cancer research : Gann 1994;85(10):992-6.
1994: Yae Kanai; T Oda; Hitoshi Tsuda; Atsushi Ochiai; Setsuo Hirohashi
Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast.
Japanese journal of cancer research : Gann 1994;85(10):1035-9.
1994: T Shibata; M Gotoh; Atsushi Ochiai; Setsuo Hirohashi
Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.
Biochemical and biophysical research communications 1994;203(1):519-22.
1994: T Oda; H Tsuda; Michiie Sakamoto; Setsuo Hirohashi
Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as a evidence for multistage progression.
Cancer letters 1994;83(1-2):197-200.
1994: H Tsuda; K Mukai; T Fukutomi; Setsuo Hirohashi
Malignant progression of adenomyoepithelial adenosis of the breast.
Pathology international 1994;44(6):475-9.
1994: Hitoshi Tsuda; Setsuo Hirohashi
Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer.
International journal of cancer. Journal international du cancer 1994;57(4):498-503.
1994: Atsushi Ochiai; S Akimoto; Y Shimoyama; A Nagafuchi; S Tsukita; Setsuo Hirohashi
Frequent loss of alpha catenin expression in scirrhous carcinomas with scattered cell growth.
Japanese journal of cancer research : Gann 1994;85(3):266-73.
1994: T Oda; Y Kanai; T Oyama; K Yoshiura; Y Shimoyama; W Birchmeier; T Sugimura; Setsuo Hirohashi
E-cadherin gene mutations in human gastric carcinoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1858-62.
1994: J H Cho; M Noguchi; A Ochiai; S Uchino; Setsuo Hirohashi
Analysis of regional differences of p53 mutation in advanced gastric carcinoma: relation to heterogeneous differentiation and invasiveness.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1994;7(2):205-11.
1994: K Aoki; M Sakamoto; Setsuo Hirohashi
Nucleolar organizer regions in small nodular lesions representing early stages of human hepatocarcinogenesis.
Cancer 1994;73(2):289-93.
1994: Hitoshi Tsuda; D F Callen; Takashi Fukutomi; Y Nakamura; Setsuo Hirohashi
Allele loss on chromosome 16q24.2-qter occurs frequently in breast cancers irrespectively of differences in phenotype and extent of spread.
Cancer research 1994;54(2):513-7.
1994: Yae Kanai; T Oda; Y Shimoyama; Atsushi Ochiai; T Oyama; K Yoshiura; S Akimoto; T Yamada; Setsuo Hirohashi
Alterations of the cadherin-catenin cell adhesion system in cancers.
Princess Takamatsu symposia 1994;24():51-62.
1994: T Kihana; Hitoshi Tsuda; S Teshima; K Nomoto; S Tsugane; T Sonoda; S Matsuura; Setsuo Hirohashi
Prognostic significance of the overexpression of c-erbB-2 protein in adenocarcinoma of the uterine cervix.
Cancer 1994;73(1):148-53.
1993: S Uchino; Hitoshi Tsuda; K Maruyama; T Kinoshita; M Sasako; T Saito; M Kobayashi; Setsuo Hirohashi
Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with long-term survival of patients.
Cancer 1993;72(11):3179-84.
1993: Y Yoshinaga; Yoshihiro Matsuno; S Fujita; T Nakamura; M Kikuchi; Y Shimosato; Setsuo Hirohashi
Immunohistochemical detection of hepatocyte growth factor/scatter factor in human cancerous and inflammatory lesions of various organs.
Japanese journal of cancer research : Gann 1993;84(11):1150-8.
1993: S Uchino; M Noguchi; Atsushi Ochiai; T Saito; M Kobayashi; Setsuo Hirohashi
p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer.
International journal of cancer. Journal international du cancer 1993;54(5):759-64.
1993: T Oda; Yae Kanai; Y Shimoyama; A Nagafuchi; S Tsukita; Setsuo Hirohashi
Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line.
Biochemical and biophysical research communications 1993;193(3):897-904.
1993: T Yamamoto; M Gotoh; M Kitajima; Setsuo Hirohashi
Thymosin beta-4 expression is correlated with metastatic capacity of colorectal carcinomas.
Biochemical and biophysical research communications 1993;193(2):706-10.
1993: T Yamamoto; M Gotoh; H Sasaki; M Terada; M Kitajima; Setsuo Hirohashi
Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1.
Biochemical and biophysical research communications 1993;193(2):681-7.
1993: Aldo Scarpa; P Capelli; K Mukai; GIUSEPPE ZAMBONI; T Oda; Calogero Iacono; Setsuo Hirohashi
Pancreatic adenocarcinomas frequently show p53 gene mutations.
The American journal of pathology 1993;142(5):1534-43.
1993: Hitoshi Tsuda; Setsuo Hirohashi
[Alterations of oncogenes in human cancers].
Gan to kagaku ryoho. Cancer & chemotherapy 1993;20(7):977-83.
1993: Aldo Scarpa; P Capelli; GIUSEPPE ZAMBONI; T Oda; K Mukai; Franco Bonetti; Guido Martignoni; Calogero Iacono; G Serio; Setsuo Hirohashi
Neoplasia of the ampulla of Vater. Ki-ras and p53 mutations.
The American journal of pathology 1993;142(4):1163-72.
1993: Hitoshi Tsuda; K Iwaya; Takashi Fukutomi; Setsuo Hirohashi
p53 mutations and c-erbB-2 amplification in intraductal and invasive breast carcinomas of high histologic grade.
Japanese journal of cancer research : Gann 1993;84(4):394-401.
1993: M Sakamoto; Y Ino; T Fujii; Setsuo Hirohashi
Phenotype changes in tumor vessels associated with the progression of hepatocellular carcinoma.
Japanese journal of clinical oncology 1993;23(2):98-104.
1993: K S Rim; M Sakamoto; H Watanabe; Yoshihiro Matsuno; Y Nakanishi; K Mukai; Setsuo Hirohashi
Pathology and DNA cytophotometry of small hepatocellular carcinoma with a nodule-in-nodule appearance--evidence for stepwise progression of hepatocellular carcinoma.
Japanese journal of clinical oncology 1993;23(1):26-33.
1993: T Kiba; Hitoshi Tsuda; C Pairojkul; S Inoue; T Sugimura; Setsuo Hirohashi
Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand.
Molecular carcinogenesis 1993;8(4):312-8.
1992: Y Yoshinaga; S Fujita; M Gotoh; T Nakamura; M Kikuchi; Setsuo Hirohashi
Human lung cancer cell line producing hepatocyte growth factor/scatter factor.
Japanese journal of cancer research : Gann 1992;83(12):1257-61.
1992: S Fujita; H Suzuki; M Kinoshita; Setsuo Hirohashi
Inhibition of cell attachment, invasion and metastasis of human carcinoma cells by anti-integrin beta 1 subunit antibody.
Japanese journal of cancer research : Gann 1992;83(12):1317-26.
1992: T Oda; Hitoshi Tsuda; Aldo Scarpa; Michiie Sakamoto; Setsuo Hirohashi
p53 gene mutation spectrum in hepatocellular carcinoma.
Cancer research 1992;52(22):6358-64.
1992: Hitoshi Tsuda; Setsuo Hirohashi
Frequent occurrence of p53 gene mutations in uterine cancers at advanced clinical stage and with aggressive histological phenotypes.
Japanese journal of cancer research : Gann 1992;83(11):1184-91.
1992: Y Shimoyama; A Nagafuchi; S Fujita; M Gotoh; M Takeichi; S Tsukita; Setsuo Hirohashi
Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness.
Cancer research 1992;52(20):5770-4.
1992: T Kihana; Hitoshi Tsuda; S Teshima; S Okada; S Matsuura; Setsuo Hirohashi
High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy.
Japanese journal of cancer research : Gann 1992;83(9):978-84.
1992: Hitoshi Tsuda; S Tsugane; Takashi Fukutomi; T Nanasawa; H Yamamoto; Setsuo Hirohashi
Prognostic factors for recurrent breast cancer: univariate and multivariate analyses including histologic grade and amplification of the c-erbB-2 proto-oncogene.
Japanese journal of clinical oncology 1992;22(4):244-9.
1992: S Sugano; K Mukai; Hitoshi Tsuda; Setsuo Hirohashi; S Furuya; Y Shimosato; S Ebihara; I Takeyama
Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness.
The Laryngoscope 1992;102(8):923-7.
1992: S Uchino; M Noguchi; T Hirota; M Itabashi; T Saito; M Kobayashi; Setsuo Hirohashi
High incidence of nuclear accumulation of p53 protein in gastric cancer.
Japanese journal of clinical oncology 1992;22(4):225-31.
1992: T Oda; Hitoshi Tsuda; Aldo Scarpa; Michiie Sakamoto; Setsuo Hirohashi
Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma.
Cancer research 1992;52(13):3674-8.
1992: S Uchino; Hitoshi Tsuda; M Noguchi; J Yokota; M Terada; T Saito; M Kobayashi; T Sugimura; Setsuo Hirohashi
Frequent loss of heterozygosity at the DCC locus in gastric cancer.
Cancer research 1992;52(11):3099-102.
1992: C A Rubio; T Hirota; M Itabashi; Setsuo Hirohashi; Y Kato
Quantitation of gastric intestinal metaplasia by morphometry in Japanese patients.
Japanese journal of cancer research : Gann 1992;83(5):495-8.
1992: Y Sato; K Mukai; S Furuya; T Kameya; Setsuo Hirohashi
The AMeX method: a multipurpose tissue-processing and paraffin-embedding method. Extraction of protein and application to immunoblotting.
The American journal of pathology 1992;140(4):775-9.
1992: Hitoshi Tsuda; T Oda; Michiie Sakamoto; Setsuo Hirohashi
Different pattern of chromosomal allele loss in multiple hepatocellular carcinomas as evidence of their multifocal origin.
Cancer research 1992;52(6):1504-9.
1992: M Noguchi; Setsuo Hirohashi; Y Shimosato
Immunohistochemical detection of cluster 1 small cell lung cancer antigen and chromogranin A in lung carcinomas.
Japanese journal of clinical oncology 1992;22(1):6-9.
1992: Yoshihiro Matsuno; K Mukai; H Uhara; I Akao; S Furuya; Y Sato; Setsuo Hirohashi; Y Shimosato
Detection of Epstein-Barr virus DNA in a Japanese case of lymphoepithelioma-like thymic carcinoma.
Japanese journal of cancer research : Gann 1992;83(2):127-30.
1992: H Nomori; Yoshihiro Matsuno; M Noguchi; S Tsugane; Y Shimosato; Setsuo Hirohashi
Adenocarcinoma of the lung with selective metastasis to the lung: clinical, histologic and DNA-cytofluorometric analyses.
Japanese journal of cancer research : Gann 1992;83(1):93-100.
1992: H Hiyoshi; Yoshihiro Matsuno; H Kato; Y Shimosato; Setsuo Hirohashi
Clinicopathological significance of nuclear accumulation of tumor suppressor gene p53 product in primary lung cancer.
Japanese journal of cancer research : Gann 1992;83(1):101-6.
1992: Hitoshi Tsuda; S Satarug; V Bhudhisawasdi; T Kihana; T Sugimura; Setsuo Hirohashi
Cholangiocarcinomas in Japanese and Thai patients: difference in etiology and incidence of point mutation of the c-Ki-ras proto-oncogene.
Molecular carcinogenesis 1992;6(4):266-9.
1991: C Rubio; T Hirota; M Itabashi; Setsuo Hirohashi; Y Kato
A possible error in the interpretation of gastric carcinoma.
Japanese journal of cancer research : Gann 1991;82(12):1354-5.
1991: Y Shimoyama; M Gotoh; Y Ino; Michiie Sakamoto; K Kato; Setsuo Hirohashi
Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1991;82(11):1263-70.
1991: M Gotoh; T Nakajima; J Yokota; Y Tsunokawa; M Terada; Y Shimoyama; S Teshima; Setsuo Hirohashi; Y Shimosato
Newly established uterine cervical carcinoma cell line with co-amplification of human papillomavirus DNA and c-myc gene.
Japanese journal of cancer research : Gann 1991;82(11):1252-7.
1991: A Gemma; M Noguchi; Setsuo Hirohashi; S Tsugane; R Tsuchiya; H Niitani; Y Shimosato
Clinicopathologic and immunohistochemical characteristics of goblet cell type adenocarcinoma of the lung.
Acta pathologica japonica 1991;41(10):737-43.
1991: Aldo Scarpa; L Borgato; Marco Chilosi; P Capelli; Fabio Menestrina; Franco Bonetti; GIUSEPPE ZAMBONI; Giovanni Pizzolo; Setsuo Hirohashi; L Fiore-Donati
Evidence of c-myc gene abnormalities in mediastinal large B-cell lymphoma of young adult age.
Blood 1991;78(3):780-8.
1991: K Iwaya; Hitoshi Tsuda; Hoshio Hiraide; K Tamaki; S Tamakuma; Takashi Fukutomi; K Mukai; Setsuo Hirohashi
Nuclear p53 immunoreaction associated with poor prognosis of breast cancer.
Japanese journal of cancer research : Gann 1991;82(7):835-40.
1991: Y Shimoyama; Setsuo Hirohashi
Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma.
Cancer letters 1991;57(2):131-5.
1991: Y Shimoyama; Setsuo Hirohashi
Expression of E- and P-cadherin in gastric carcinomas.
Cancer research 1991;51(8):2185-92.
1991: T Kihana; Hitoshi Tsuda; T Hirota; Y Shimosato; H Sakamoto; M Terada; Setsuo Hirohashi
Point mutation of c-Ki-ras oncogene in gastric adenoma and adenocarcinoma with tubular differentiation.
Japanese journal of cancer research : Gann 1991;82(3):308-14.
1991: M Sakamoto; Setsuo Hirohashi; Y Shimosato
Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma.
Human pathology 1991;22(2):172-8.
1991: Setsuo Hirohashi
Pathology and molecular mechanisms of multistage human hepatocarcinogenesis.
Princess Takamatsu symposia 1991;22():87-93.
1991: Hitoshi Tsuda; Setsuo Hirohashi; T Hirota; Y Shimosato
Alterations in copy number of c-erbB-2 and c-myc proto-oncogenes in advanced stage of human breast cancer.
Acta pathologica japonica 1991;41(1):19-23.
1990: K Yuki; Setsuo Hirohashi; M Sakamoto; T Kanai; Y Shimosato
Growth and spread of hepatocellular carcinoma. A review of 240 consecutive autopsy cases.
Cancer 1990;66(10):2174-9.
1990: M Noguchi; Setsuo Hirohashi; F Hara; A Kojima; Y Shimosato; T Shinkai; R Tsuchiya
Heterogenous amplification of myc family oncogenes in small cell lung carcinoma.
Cancer 1990;66(10):2053-8.
1990: Yoshihiro Matsuno; Setsuo Hirohashi; S Furuya; Michiie Sakamoto; K Mukai; Y Shimosato
Heterogeneity of proliferative activity in nodule-in-nodule lesions of small hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1990;81(11):1137-40.
1990: Hitoshi Tsuda; W D Zhang; Y Shimosato; J Yokota; M Terada; T Sugimura; T Miyamura; Setsuo Hirohashi
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6791-4.
1990: T Kobayashi; Hitoshi Tsuda; M Noguchi; Setsuo Hirohashi; Y Shimosato; T Goya; Y Hayata
Association of point mutation in c-Ki-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes.
Cancer 1990;66(2):289-94.
1990: Hitoshi Tsuda; Setsuo Hirohashi; K Higuchi; Y Shimosato
Beta-2-microglobulin expression in relation to amplification of oncogenes and prognosis in breast carcinoma.
Histopathology 1990;16(5):500-2.
1990: Hitoshi Tsuda; Setsuo Hirohashi; Y Shimosato; Y Tanaka; T Hirota; S Tsugane; M Shiraishi; K Toyoshima; T Yamamoto; M Terada
Immunohistochemical study on overexpression of c-erbB-2 protein in human breast cancer: its correlation with gene amplification and long-term survival of patients.
Japanese journal of cancer research : Gann 1990;81(4):327-32.
1990: W D Zhang; Setsuo Hirohashi; Hitoshi Tsuda; Y Shimosato; J Yokota; M Terada; T Sugimura
Frequent loss of heterozygosity on chromosomes 16 and 4 in human hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1990;81(2):108-11.
1990: K Mukai; Y Sato; Setsuo Hirohashi; Y Shimosato
Expression of ras p21 protein by thymoma.
Virchows Archiv. B, Cell pathology including molecular pathology 1990;59(1):11-6.
1989: Y Koshiishi; M Noguchi; T Nakajima; Setsuo Hirohashi; Y Shimosato; Y Hayata
Immunohistochemical and immunoblot analyses of ras-p21 expression in lung carcinomas.
Acta pathologica japonica 1989;39(10):643-7.
1989: Hitoshi Tsuda; Setsuo Hirohashi; Y Shimosato; T Hirota; S Tsugane; H Yamamoto; N Miyajima; K Toyoshima; T Yamamoto; J Yokota
Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.
Cancer research 1989;49(11):3104-8.
1989: Y Shimoyama; Setsuo Hirohashi; S Hirano; M Noguchi; Y Shimosato; M Takeichi; O Abe
Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.
Cancer research 1989;49(8):2128-33.
1989: T Hirano; Setsuo Hirohashi; T Kunii; M Noguchi; Y Shimosato; Y Hayata
Quantitative distribution of cluster 1 small cell lung cancer antigen in cancerous and non-cancerous tissues, cultured cells and sera.
Japanese journal of cancer research : Gann 1989;80(4):348-55.
1989: Hitoshi Tsuda; Setsuo Hirohashi; Y Shimosato; Y Ino; T Yoshida; M Terada
Low incidence of point mutation of c-Ki-ras and N-ras oncogenes in human hepatocellular carcinoma.
Japanese journal of cancer research : Gann 1989;80(3):196-9.
1989: M Noguchi; T Nakajima; Setsuo Hirohashi; T Akiba; Y Shimosato
Immunohistochemical distinction of malignant mesothelioma from pulmonary adenocarcinoma with anti-surfactant apoprotein, anti-Lewisa, and anti-Tn antibodies.
Human pathology 1989;20(1):53-7.
1988: M Noguchi; Setsuo Hirohashi; Hitoshi Tsuda; T Nakajima; F Hara; Y Shimosato
Detection of amplified N-myc gene in neuroblastoma by in situ hybridization using the single-step silver enhancement method.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1988;1(6):428-32.
1988: S Teshima; Y Shimosato; Setsuo Hirohashi; Y Tome; I Hayashi; H Kanazawa; T Kakizoe
Four new human germ cell tumor cell lines.
Laboratory investigation; a journal of technical methods and pathology 1988;59(3):328-36.
1988: Y Sakurai; Setsuo Hirohashi; Y Shimosato; S Kodaira; O Abe
Selection of a monoclonal antibody reactive with a high-molecular-weight glycoprotein circulating in the body fluid of gastrointestinal cancer patients.
Cancer research 1988;48(14):4053-8.
1988: Setsuo Hirohashi
[Analysis of oncogene and its expression at cellular level].
Human cell 1988;1(1):17-9.
1987: T Kanai; Setsuo Hirohashi; M Noguchi; Y Shimoyama; Y Shimosato; S Noguchi; S Nishimura; O Abe
Monoclonal antibody highly sensitive for the detection of ras p21 in immunoblotting analysis.
Japanese journal of cancer research : Gann 1987;78(12):1314-8.
1987: T Kanai; Setsuo Hirohashi; M P Upton; Y Ino; Y Shimosato
Expression of Lewis blood group antigens in cancerous and non-cancerous liver.
Japanese journal of cancer research : Gann 1987;78(9):968-76.