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Yukio Hiroi

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Anatomy

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Koshiro Monzen; Yuzuru Ito; Atsuhiko T Naito; Hiroki Kasai; Yukio Hiroi; Doubun Hayashi; Ichiro Shiojima; Tsutomu Yamazaki; Kohei Miyazono; Makoto Asashima; Ryozo Nagai; Issei Komuro
A crucial role of a high mobility group protein HMGA2 in cardiogenesis.
Yasushi Mukai; Yoshiyuki Rikitake; Ichiro Shiojima; Sebastian Wolfrum; Minoru Satoh; Kyosuke Takeshita; Yukio Hiroi; Salvatore Salomone; Hyung-Hwan Kim; Laura E Benjamin; Kenneth Walsh; James K Liao
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.
Yukio Hiroi; Katsuhito Fujiu; Shuhei Komatsu; Makoto Sonoda; Yasunari Sakomura; Yasushi Imai; Yumi Oishi; Fumitaka Nakamura; Kohsuke Ajiki; Noriyuki Hayami; Yuji Murakawa; Minoru Ohno; Yasunobu Hirata; Kuni Ohtomo; Ryozo Nagai
Carvedilol therapy improved left ventricular function in a patient with arrhythmogenic right ventricular cardiomyopathy.

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All Publications

2008: Koshiro Monzen; Yuzuru Ito; Atsuhiko T Naito; Hiroki Kasai; Yukio Hiroi; Doubun Hayashi; Ichiro Shiojima; Tsutomu Yamazaki; Kohei Miyazono; Makoto Asashima; Ryozo Nagai; Issei Komuro
A crucial role of a high mobility group protein HMGA2 in cardiogenesis.
Nature cell biology 2008;10(5):567-74.
2006: Yasushi Mukai; Yoshiyuki Rikitake; Ichiro Shiojima; Sebastian Wolfrum; Minoru Satoh; Kyosuke Takeshita; Yukio Hiroi; Salvatore Salomone; Hyung-Hwan Kim; Laura E Benjamin; Kenneth Walsh; James K Liao
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.
The Journal of clinical investigation 2006;116(2):334-43.
2004: Yukio Hiroi; Katsuhito Fujiu; Shuhei Komatsu; Makoto Sonoda; Yasunari Sakomura; Yasushi Imai; Yumi Oishi; Fumitaka Nakamura; Kohsuke Ajiki; Noriyuki Hayami; Yuji Murakawa; Minoru Ohno; Yasunobu Hirata; Kuni Ohtomo; Ryozo Nagai
Carvedilol therapy improved left ventricular function in a patient with arrhythmogenic right ventricular cardiomyopathy.
Japanese heart journal 2004;45(1):169-77.
2003: Rui Chen; Vernon Anderson; Yukio Hiroi; M Edward Medof
Proprotein interaction with the GPI transamidase.
Journal of cellular biochemistry 2003;88(5):1025-37.
2003: Yukio Hiroi; Tomoko Nakao; Naoyuki Tsuchiya; Norihiko Takeda; Koji Maemura; Fumitaka Nakamura; Minoru Ohno; Yasunobu Hirata; Ryozo Nagai
Exacerbation of Lambert-Eaton myasthenic syndrome caused by an L-type Ca2+ channel antagonist.
Japanese heart journal 2003;44(1):139-44.
2002: Koshiro Monzen; Weidong Zhu; Hiroki Kasai; Yukio Hiroi; Toru Hosoda; Hiroshi Akazawa; Yunzeng Zou; Doubun Hayashi; Tsutomu Yamazaki; Ryozo Nagai; Issei Komuro
Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes.
Biochemical and biophysical research communications 2002;298(4):493-500.
2002: Haruhiro Toko; Weidong Zhu; Eiki Takimoto; Ichiro Shiojima; Yukio Hiroi; Yunzeng Zou; Toru Oka; Hiroshi Akazawa; Miho Mizukami; Masaya Sakamoto; Fumio Terasaki; Yasushi Kitaura; Hiroyuki Takano; Toshio Nagai; Ryozo Nagai; Issei Komuro
Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart.
The Journal of biological chemistry 2002;277(27):24735-43.
2002: Yuichi Ikeda; Yukio Hiroi; Toru Hosoda; Toshinori Utsunomiya; Shuzo Matsuo; Tsuyoshi Ito; Jun-ichi Inoue; Tetsuya Sumiyoshi; Hiroyuki Takano; Ryozo Nagai; Issei Komuro
Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(6):561-3.
2002: Norifumi Takeda; Ikuo Yokoyama; Yukio Hiroi; M Sakata; T Harada; Fumitaka Nakamura; Yuji Murakawa; Ryozo Nagai
Positron emission tomography predicted recovery of complete A-V nodal dysfunction in a patient with cardiac sarcoidosis.
Circulation 2002;105(9):1144-5.
2002: Tomohiro Harada; Teruhiko Aoyagi; Yoko Endo; Kansei Uno; Katsu Takenaka; Fumitaka Nakamura; Makoto Sonoda; Toshiyuki Takahashi; Tadashi Yamazaki; Yukio Hiroi; Minoru Ohno; Yasunobu Hirata; Ryozo Nagai
Effusive constrictive pericarditis due to rheumatoid arthritis revealed by pericardiocentesis with simultaneous pressure recording--a case report.
Angiology 2002;53(1):105-8.
2001: Toru Hosoda; Koshiro Monzen; Yukio Hiroi; Toru Oka; Eiki Takimoto; Yoshio Yazaki; Ryozo Nagai; Issei Komuro
A novel myocyte-specific gene Midori promotes the differentiation of P19CL6 cells into cardiomyocytes.
The Journal of biological chemistry 2001;276(38):35978-89.
2001: Yunzeng Zou; A Yao; Weidong Zhu; Sumiyo Kudoh; Yukio Hiroi; Masaki Shimoyama; Hiroki Uozumi; Osami Kohmoto; Tokiharu Takahashi; Futoshi Shibasaki; Ryozo Nagai; Yoshio Yazaki; Issei Komuro
Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin.
Circulation 2001;104(1):102-8.
2001: Yunzeng Zou; Yukio Hiroi; Hiroki Uozumi; Eiki Takimoto; Haruhiro Toko; Weidong Zhu; Sumiyo Kudoh; Miho Mizukami; Masaki Shimoyama; Futoshi Shibasaki; Ryozo Nagai; Yoshio Yazaki; Issei Komuro
Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy.
Circulation 2001;104(1):97-101.
2001: Yukio Hiroi; Junya Hiroi; Sumiyo Kudoh; Yoshio Yazaki; Ryozo Nagai; Issei Komuro
Two distinct mechanisms of angiotensin II-induced negative regulation of the mitogen-activated protein kinases in cultured cardiac myocytes.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(4):385-94.
2001: Yukio Hiroi; S Kudoh; Koshiro Monzen; Y Ikeda; Yoshio Yazaki; Ryozo Nagai; I Komuro
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.
Nature genetics 2001;28(3):276-80.
2001: Hiroki Uozumi; Yukio Hiroi; Yunzeng Zou; Eiki Takimoto; Haruhiro Toko; Pei Niu; Masaki Shimoyama; Yoshio Yazaki; Ryozo Nagai; Issei Komuro
gp130 plays a critical role in pressure overload-induced cardiac hypertrophy.
The Journal of biological chemistry 2001;276(25):23115-9.
2001: Koshiro Monzen; Yukio Hiroi; Sumiyo Kudoh; Hiroshi Akazawa; Toru Oka; Eiki Takimoto; Doubun Hayashi; Toru Hosoda; M Kawabata; Kohei Miyazono; S Ishii; Yoshio Yazaki; Ryozo Nagai; Issei Komuro
Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.
The Journal of cell biology 2001;153(4):687-98.
2000: Weidong Zhu; Ichiro Shiojima; Yukio Hiroi; Yunzeng Zou; Hiroshi Akazawa; Miho Mizukami; Haruhiro Toko; Yoshio Yazaki; Ryozo Nagai; Issei Komuro
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease.
The Journal of biological chemistry 2000;275(45):35291-6.
2000: S Saito; Yukio Hiroi; Yunzeng Zou; Ryuichi Aikawa; Haruhiro Toko; Futoshi Shibasaki; Yoshio Yazaki; Ryozo Nagai; Issei Komuro
beta-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes.
The Journal of biological chemistry 2000;275(44):34528-33.
2000: Masaki Shimoyama; Doubun Hayashi; Yunzeng Zou; Eiki Takimoto; Miho Mizukami; Koshiro Monzen; Sumiyo Kudoh; Yukio Hiroi; Yoshio Yazaki; Ryozo Nagai; Issei Komuro
Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension.
Circulation 2000;102(16):1996-2004.
2000: Yukio Hiroi; R Chen; H Sawa; Toru Hosoda; Sumiyo Kudoh; Y Kobayashi; Hiroyuki Aburatani; K Nagashima; Ryozo Nagai; Yoshio Yazaki; M Edward Medof; Issei Komuro
Cloning of murine glycosyl phosphatidylinositol anchor attachment protein, GPAA1.
American journal of physiology. Cell physiology 2000;279(1):C205-12.
2000: Ichiro Shiojima; Toru Oka; Yukio Hiroi; Ryozo Nagai; Yoshio Yazaki; Issei Komuro
Transcriptional regulation of human cardiac homeobox gene CSX1.
Biochemical and biophysical research communications 2000;272(3):749-57.
2000: Eiki Takimoto; T Mizuno; Fumio Terasaki; Masaki Shimoyama; Hiroaki Honda; Ichiro Shiojima; Yukio Hiroi; Toru Oka; Doubun Hayashi; Hisamura Hirai; Sumiyo Kudoh; Haruhiro Toko; K Kawamura; Ryozo Nagai; Yoshio Yazaki; Issei Komuro
Up-regulation of natriuretic peptides in the ventricle of Csx/Nkx2-5 transgenic mice.
Biochemical and biophysical research communications 2000;270(3):1074-9.
2000: T Oka; Ichiro Shiojima; Koshiro Monzen; S Kudoh; Yukio Hiroi; Koichiro Shiokawa; M Asashima; Ryozo Nagai; Yoshio Yazaki; Issei Komuro
Fibroblast growth factor plays a critical role in SM22alpha expression during Xenopus embryogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(4):907-14.
1999: Koshiro Monzen; Ichiro Shiojima; Yukio Hiroi; Sumiyo Kudoh; Toru Oka; Eiki Takimoto; Doubun Hayashi; Toru Hosoda; A Habara-Ohkubo; Takashi Nakaoka; T Fujita; Yoshio Yazaki; Issei Komuro
Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4.
Molecular and cellular biology 1999;19(10):7096-105.
1999: Toru Hosoda; Issei Komuro; Ichiro Shiojima; Yukio Hiroi; M Harada; Yuji Murakawa; Yasunobu Hirata; Yoshio Yazaki
Familial atrial septal defect and atrioventricular conduction disturbance associated with a point mutation in the cardiac homeobox gene CSX/NKX2-5 in a Japanese patient.
Japanese circulation journal 1999;63(5):425-6.
1999: Ichiro Shiojima; Issei Komuro; Toru Oka; Yukio Hiroi; T Mizuno; Eiki Takimoto; Koshiro Monzen; Ryuichi Aikawa; Hiroshi Akazawa; Tadashi Yamazaki; Sumiyo Kudoh; Yoshio Yazaki
Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.
The Journal of biological chemistry 1999;274(12):8231-9.
1998: Yukio Hiroi; Issei Komuro; Ikumi Matsushita; Hiroyuki Aburatani; Toru Hosoda; Yutaka Nakahori; M Edward Medof; Yoshio Yazaki
Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24.
Genomics 1998;54(2):354-5.
1998: Sumiyo Kudoh; Issei Komuro; Yukio Hiroi; Yunzeng Zou; Kenji Harada; Takeshi Sugaya; N Takekoshi; Koji Murakami; Takashi Kadowaki; Yoshio Yazaki
Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice.
The Journal of biological chemistry 1998;273(37):24037-43.
1998: Hiroyuki Takano; Issei Komuro; Toru Oka; Ichiro Shiojima; Yukio Hiroi; T Mizuno; Yoshio Yazaki
The Rho family G proteins play a critical role in muscle differentiation.
Molecular and cellular biology 1998;18(3):1580-9.
1998: Yunzeng Zou; Issei Komuro; Tadashi Yamazaki; Sumiyo Kudoh; Ryuichi Aikawa; W Zhu; Ichiro Shiojima; Yukio Hiroi; Kazuyuki Tobe; Takashi Kadowaki; Yoshio Yazaki
Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts.
Circulation research 1998;82(3):337-45.
1998: Yukio Hiroi; Issei Komuro; R Chen; Toru Hosoda; T Mizuno; Sumiyo Kudoh; S P Georgescu; M Edward Medof; Yoshio Yazaki
Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins.
FEBS letters 1998;421(3):252-8.
1998: T Yamazaki; Issei Komuro; Yunzeng Zou; Sumiyo Kudoh; Ichiro Shiojima; T Mizuno; Yukio Hiroi; Ryozo Nagai; Yoshio Yazaki
Efficient inhibition of the development of cardiac remodeling by a long-acting calcium antagonist amlodipine.
Hypertension 1998;31(1):32-8.
1997: Ryuichi Aikawa; Issei Komuro; T Yamazaki; Y Zou; S Kudoh; M Tanaka; Ichiro Shiojima; Yukio Hiroi; Yoshio Yazaki
Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.
The Journal of clinical investigation 1997;100(7):1813-21.
1997: Tadashi Yamazaki; Issei Komuro; Yunzeng Zou; Sumiyo Kudoh; T Mizuno; Yukio Hiroi; Ichiro Shiojima; Hiroyuki Takano; Koichiro Kinugawa; Osami Kohmoto; Tokiharu Takahashi; Yoshio Yazaki
Protein kinase A and protein kinase C synergistically activate the Raf-1 kinase/mitogen-activated protein kinase cascade in neonatal rat cardiomyocytes.
Journal of molecular and cellular cardiology 1997;29(9):2491-501.
1997: Tadashi Yamazaki; Issei Komuro; Yunzeng Zou; Sumiyo Kudoh; Ichiro Shiojima; Yukio Hiroi; T Mizuno; Ryuichi Aikawa; Hiroyuki Takano; Yoshio Yazaki
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
Circulation 1997;95(5):1260-8.
1997: S P Georgescu; Issei Komuro; Yukio Hiroi; T Mizuno; Sumiyo Kudoh; Tadashi Yamazaki; Yoshio Yazaki
Downregulation of polo-like kinase correlates with loss of proliferative ability of cardiac myocytes.
Journal of molecular and cellular cardiology 1997;29(3):929-37.
1997: Toru Oka; Issei Komuro; Ichiro Shiojima; Yukio Hiroi; T Mizuno; Ryuichi Aikawa; Hiroshi Akazawa; T Yamazaki; Yoshio Yazaki
Autoregulation of human cardiac homeobox gene CSX1: mediation by the enhancer element in the first intron.
Heart and vessels 1997;Suppl 12():10-4.
1996: Yunzeng Zou; Issei Komuro; Tadashi Yamazaki; Ryuichi Aikawa; Sumiyo Kudoh; Ichiro Shiojima; Yukio Hiroi; T Mizuno; Y Yazaki
Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes.
The Journal of biological chemistry 1996;271(52):33592-7.
1996: Tadashi Yamazaki; Issei Komuro; Sumiyo Kudoh; Yunzeng Zou; Ichiro Shiojima; Yukio Hiroi; T Mizuno; Koji Maemura; Hiroki Kurihara; Ryuichi Aikawa; Hiroyuki Takano; Y Yazaki
Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy.
The Journal of biological chemistry 1996;271(6):3221-8.
1995: Tadashi Yamazaki; Issei Komuro; Sumiyo Kudoh; Yunzeng Zou; Ichiro Shiojima; T Mizuno; H Takano; Yukio Hiroi; Keisuke Ueki; Kazuyuki Tobe
Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy.
Circulation research 1995;77(2):258-65.
1995: Tadashi Yamazaki; Issei Komuro; Sumiyo Kudoh; Yunzeng Zou; Ichiro Shiojima; T Mizuno; Hiroyuki Takano; Yukio Hiroi; Keisuke Ueki; Kazuyuki Tobe
Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes.
The Journal of clinical investigation 1995;96(1):438-46.
1995: Makoto Kuro-o; K Hanaoka; Yukio Hiroi; T Noguchi; Y Fujimori; S Takewaki; M Hayasaka; H Katoh; A Miyagishi; Ryozo Nagai
Salt-sensitive hypertension in transgenic mice overexpressing Na(+)-proton exchanger.
Circulation research 1995;76(1):148-53.
1995: S Takewaki; Makoto Kuro-o; Yukio Hiroi; Tadashi Yamazaki; T Noguchi; A Miyagishi; K Nakahara; M Aikawa; Ichiro Manabe; Y Yazaki
Activation of Na(+)-H+ antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system.
Journal of molecular and cellular cardiology 1995;27(1):729-42.