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Takatsugu Hirokawa

Research Profile

Chemicals & Drugs

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Genes & Molecular Sequences

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Publications

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Junko Abe; Rui Higashikuni; Michiko Hirata; Takatsugu Hirokawa; Keisuke Iida; Masaki Inada; Kaichiro Kominato; Chisato Miyaura; Hazuki Nagai; Yu Nagai; Toshio Tsuchida; Kazuo Nagasawa
Synthesis of vitamin D3 derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity.
Ryoko Shinohara; Kaoru Yamaoka; Mari Yotsu-Yamashita; Takafumi Akimoto; Takatsugu Hirokawa; Osamu Iwamoto; Kazuo Nagasawa
Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.
Keisuke Iida; Masayuki Tera; Takatsugu Hirokawa; Kazuo Shin-Ya; Kazuo Nagasawa
Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties.

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All Publications

2012: Junko Abe; Rui Higashikuni; Michiko Hirata; Takatsugu Hirokawa; Keisuke Iida; Masaki Inada; Kaichiro Kominato; Chisato Miyaura; Hazuki Nagai; Yu Nagai; Toshio Tsuchida; Kazuo Nagasawa
Synthesis of vitamin D3 derivatives with nitrogen-linked substituents at A-ring C-2 and evaluation of their vitamin D receptor-mediated transcriptional activity.
Organic & biomolecular chemistry 2012;10(38):7826-39.
2011: Ryoko Shinohara; Kaoru Yamaoka; Mari Yotsu-Yamashita; Takafumi Akimoto; Takatsugu Hirokawa; Osamu Iwamoto; Kazuo Nagasawa
Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(43):12144-52.
2010: Keisuke Iida; Masayuki Tera; Takatsugu Hirokawa; Kazuo Shin-Ya; Kazuo Nagasawa
Synthesis of Macrocyclic Hexaoxazole (6OTD) Dimers, Containing Guanidine and Amine Functionalized Side Chains, and an Evaluation of Their Telomeric G4 Stabilizing Properties.
Journal of nucleic acids 2010;2010():.
2009: Keisuke Iida; Masayuki Tera; Takatsugu Hirokawa; Kazuo Shin-Ya; Kazuo Nagasawa
G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer.
Chemical communications (Cambridge, England) 2009;(42):6481-3.
2002: Shigeki Mitaku; Takatsugu Hirokawa; Toshiyuki Tsuji
Amphiphilicity index of polar amino acids as an aid in the characterization of amino acid preference at membrane-water interfaces.
Bioinformatics (Oxford, England) 2002;18(4):608-16.
2000: Takatsugu Hirokawa; J Uechi; H Sasamoto; M Suwa; Shigeki Mitaku
A triangle lattice model that predicts transmembrane helix configuration using a polar jigsaw puzzle.
Protein engineering 2000;13(11):771-8.
1999: Shigeki Mitaku; M Ono; Takatsugu Hirokawa; S Boon-Chieng; Masashi Sonoyama
Proportion of membrane proteins in proteomes of 15 single-cell organisms analyzed by the SOSUI prediction system.
Biophysical chemistry 1999;82(2-3):165-71.
1999: Shigeki Mitaku; Takatsugu Hirokawa
Physicochemical factors for discriminating between soluble and membrane proteins: hydrophobicity of helical segments and protein length.
Protein engineering 1999;12(11):953-7.
1998: Takatsugu Hirokawa; S Boon-Chieng; Shigeki Mitaku
SOSUI: classification and secondary structure prediction system for membrane proteins.
Bioinformatics (Oxford, England) 1998;14(4):378-9.
1997: Shigeki Mitaku; Takatsugu Hirokawa
[Structure prediction of membrane proteins: discrimination of membrane proteins and secondary structure prediction].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1997;42(17 Suppl):3020-5.
1995: M Suwa; Takatsugu Hirokawa; Shigeki Mitaku
A continuum theory for the prediction of lateral and rotational positioning of alpha-helices in membrane proteins: bacteriorhodopsin.
Proteins 1995;22(4):363-77.