FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Yoshitaka Hirooka

Research Profile

Disorders

Living Beings

Anatomy

Chemicals & Drugs

Physiology

Regional Blood Flow

Co-author Network

Publications

TOP 3
Masatsugu Nakano; Yoshitaka Hirooka; Koji Ito; Ryuichi Matsukawa; Kenji Sunagawa
Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats.
Takuya Kishi; Yoshitaka Hirooka
Sympathoexcitation associated with Renin-Angiotensin system in metabolic syndrome.
Ryuichi Matsukawa; Yoshitaka Hirooka; Koji Ito; Kenji Sunagawa
Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Yoshitaka Hirooka (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Masatsugu Nakano; Yoshitaka Hirooka; Koji Ito; Ryuichi Matsukawa; Kenji Sunagawa
Mineralocorticoid receptors/epithelial Na(+) channels in the choroid plexus are involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2013;36(3):277-84.
2013: Takuya Kishi; Yoshitaka Hirooka
Sympathoexcitation associated with Renin-Angiotensin system in metabolic syndrome.
International journal of hypertension 2013;2013():406897.
2013: Ryuichi Matsukawa; Yoshitaka Hirooka; Koji Ito; Kenji Sunagawa
Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis.
American journal of hypertension 2013;26(1):51-7.
2012: Takuya Kishi; Yoshitaka Hirooka; Kenji Sunagawa
Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats.
Journal of cardiology 2012;60(6):489-94.
2012: Satomi Konno; Yoshitaka Hirooka; Takuya Kishi; Kenji Sunagawa
Sympathoinhibitory effects of telmisartan through the reduction of oxidative stress in the rostral ventrolateral medulla of obesity-induced hypertensive rats.
Journal of hypertension 2012;30(10):1992-9.
2012: Masaaki Nishihara; Yoshitaka Hirooka; Takuya Kishi; Kenji Sunagawa
Different role of oxidative stress in paraventricular nucleus and rostral ventrolateral medulla in cardiovascular regulation in awake spontaneously hypertensive rats.
Journal of hypertension 2012;30(9):1758-65.
2012: Takuya Kishi; Yoshitaka Hirooka; Kenji Sunagawa
Sympathoinhibition caused by orally administered telmisartan through inhibition of the AT₁ receptor in the rostral ventrolateral medulla of hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2012;35(9):940-6.
2012: Takuya Kishi; Satomi Konno; Yoshitaka Hirooka; Kenji Sunagawa
Angiotensin II receptor blockers improve endothelial dysfunction associated with sympathetic hyperactivity in metabolic syndrome.
Journal of hypertension 2012;30(8):1646-55.
2012: Keisuke Shinohara; Yoshitaka Hirooka; Takuya Kishi; Kenji Sunagawa
Reduction of nitric oxide-mediated γ-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(12):2814-21.
2012: Takuya Kishi; Yoshitaka Hirooka
Oxidative stress in the brain causes hypertension via sympathoexcitation.
Frontiers in physiology 2012;3():335.
2012: Takuya Kishi; Yoshitaka Hirooka
Central mechanisms of abnormal sympathoexcitation in chronic heart failure.
Cardiology research and practice 2012;2012():847172.
2012: Kiyohiro Ogawa; Keisuke Shinohara; Yoshitaka Hirooka; Takuya Kishi; Kenji Sunagawa
Inhibition of oxidative stress in rostral ventrolateral medulla improves impaired baroreflex sensitivity in stroke-prone spontaneously hypertensive rats.
International heart journal 2012;53(3):193-8.
2012: Takuya Kishi; Kiyohiro Ogawa; Keisuke Shinohara; Yoshitaka Hirooka; Kengo Isegawa; Masato Katsuki; Kenji Sunagawa
Exercise training causes sympathoinhibition through antioxidant effect in the rostral ventrolateral medulla of hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2012;34(4):278-83.
2012: Keisuke Shinohara; Yoshitaka Hirooka; Takuya Kishi; Kiyohiro Ogawa; Hideo Utsumi; Keiji Yasukawa; Kenji Sunagawa
Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2012;34(6):456-62.
2011: Kiyohiro Ogawa; Yoshitaka Hirooka; Takuya Kishi; Kenji Sunagawa
Brain AT1 receptor activates the sympathetic nervous system through toll-like receptor 4 in mice with heart failure.
Journal of cardiovascular pharmacology 2011;58(5):543-9.
2011: Ryuichi Matsukawa; Masaaki Nishihara; Yoshitaka Hirooka; Koji Ito; Kenji Sunagawa
Neuregulin-1/ErbB signaling in rostral ventrolateral medulla is involved in blood pressure regulation as an antihypertensive system.
Journal of hypertension 2011;29(9):1735-42.
2011: Yoshitaka Hirooka
Oxidative stress in the cardiovascular center has a pivotal role in the sympathetic activation in hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 2011;34(4):407-12.
2011: Yoshitaka Hirooka; Takuya Kishi; Koji Sakai; Akira Takeshita; Kenji Sunagawa
Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;300(4):R818-26.
2011: Takuya Kishi; Satomi Konno; Kiyohiro Ogawa; Yoshitaka Hirooka; Kenji Sunagawa
Calorie restriction inhibits sympathetic nerve activity via anti-oxidant effect in the rostral ventrolateral medulla of obesity-induced hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2011;33(4):240-5.
2011: Toshiaki Nakagaki; Yoshitaka Hirooka; Sumio Hoka; Koji Ito; Takuya Kishi; Kenji Sunagawa
Role of angiotensin-(1-7) in rostral ventrolateral medulla in blood pressure regulation via sympathetic nerve activity in Wistar-Kyoto and spontaneous hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2011;33(4):223-30.
2010: Takuya Kishi; Yoshitaka Hirooka
Sympathoinhibitory effects of atorvastatin in hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(12):2552-3.
2010: Koji Ito; Yoshitaka Hirooka; Kenji Sunagawa
Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload.
Journal of hypertension 2010;28(7):1449-58.
2010: Yoshitaka Hirooka; Yoji Sagara; Takuya Kishi; Kenji Sunagawa
Oxidative stress and central cardiovascular regulation. - Pathogenesis of hypertension and therapeutic aspects -.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(5):827-35.
2010: Nami Someya; Masako Yamaoka Endo; Yoshiyuki Fukuba; Yoshitaka Hirooka; Naoyuki Hayashi
Effects of a mental task on splanchnic blood flow in fasting and postprandial conditions.
European journal of applied physiology 2010;108(6):1107-13.
2010: Takuya Kishi; Yoshitaka Hirooka; Satomi Konno; Kiyohiro Ogawa; Kenji Sunagawa
Angiotensin II type 1 receptor-activated caspase-3 through ras/mitogen-activated protein kinase/extracellular signal-regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats.
Hypertension 2010;55(2):291-7.
2010: Takuya Kishi; Yoshitaka Hirooka; Satomi Konno; Kenji Sunagawa
Sympathoinhibition induced by centrally administered atorvastatin is associated with alteration of NAD(P)H and Mn superoxide dismutase activity in rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.
Journal of cardiovascular pharmacology 2010;55(2):184-90.
2010: Yoshitaka Hirooka; Kenji Sunagawa
[Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and autonomic nervous system].
Clinical calcium 2010;20(1):32-7.
2009: Shuichiro Araki; Yoshitaka Hirooka; Takuya Kishi; Keiji Yasukawa; Hideo Utsumi; Kenji Sunagawa
Olmesartan reduces oxidative stress in the brain of stroke-prone spontaneously hypertensive rats assessed by an in vivo ESR method.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(12):1091-6.
2009: Takuya Kishi; Yoshitaka Hirooka; Satomi Konno; Kenji Sunagawa
Atorvastatin improves the impaired baroreflex sensitivity via anti-oxidant effect in the rostral ventrolateral medulla of SHRSP.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2009;31(8):698-704.
2009: Naoyuki Hayashi; Nami Someya; Toru Maruyama; Yoshitaka Hirooka; Masako Yamaoka Endo; Yoshiyuki Fukuba
Vascular responses to fear-induced stress in humans.
Physiology & behavior 2009;98(4):441-6.
2009: Yoshikuni Kimura; Yoshitaka Hirooka; Takuya Kishi; Koji Ito; Yoji Sagara; Kenji Sunagawa
Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2009;31(3):281-6.
2009: Takuya Kishi; Yoshitaka Hirooka; Satomi Konno; Kenji Sunagawa
Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2009;31(3):241-9.
2009: Koji Ito; Yoshitaka Hirooka; Kenji Sunagawa
Acquisition of brain Na sensitivity contributes to salt-induced sympathoexcitation and cardiac dysfunction in mice with pressure overload.
Circulation research 2009;104(8):1004-11.
2008: Koji Ito; Yoshikuni Kimura; Yoshitaka Hirooka; Yoji Sagara; Kenji Sunagawa
Activation of Rho-kinase in the brainstem enhances sympathetic drive in mice with heart failure.
Autonomic neuroscience : basic & clinical 2008;142(1-2):77-81.
2008: Yoshitaka Hirooka
Role of reactive oxygen species in brainstem in neural mechanisms of hypertension.
Autonomic neuroscience : basic & clinical 2008;142(1-2):20-4.
2008: Masatsugu Nozoe; Yoshitaka Hirooka; Yasuaki Koga; Shuichiro Araki; Satomi Konno; Takuya Kishi; Tomomi Ide; Kenji Sunagawa
Mitochondria-derived reactive oxygen species mediate sympathoexcitation induced by angiotensin II in the rostral ventrolateral medulla.
Journal of hypertension 2008;26(11):2176-84.
2008: Naoyuki Hayashi; Nami Someya; Yoshitaka Hirooka; Shunsaku Koga
Ambient temperature affects glabrous skin vasculature and sweating responses to mental task in humans.
Journal of physiological anthropology 2008;27(5):227-31.
2008: Yoshitaka Hirooka; Yoshikuni Kimura; Yoji Sagara; Koji Ito; Kenji Sunagawa
Effects of valsartan or amlodipine on endothelial function and oxidative stress after one year follow-up in patients with essential hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2008;30(3):267-76.
2008: Takaki Tsutsumi; Tomomi Ide; Mayumi Yamato; Wataru Kudou; Makoto Andou; Yoshitaka Hirooka; Hideo Utsumi; Hiroyuki Tsutsui; Kenji Sunagawa
Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction.
Cardiovascular research 2008;77(4):713-21.
2008: Takuya Kishi; Yoshitaka Hirooka; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Atorvastatin reduces oxidative stress in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2008;30(1):3-11.
2007: Masatsugu Nozoe; Yoshitaka Hirooka; Yasuaki Koga; Yoji Sagara; Takuya Kishi; John F Engelhardt; Kenji Sunagawa
Inhibition of Rac1-derived reactive oxygen species in nucleus tractus solitarius decreases blood pressure and heart rate in stroke-prone spontaneously hypertensive rats.
Hypertension 2007;50(1):62-8.
2007: Takuya Kishi; Yoshitaka Hirooka
[Abnormal peripheral circulation in patients with heart failure].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 4():316-20.
2007: Yoshihiro Fukumoto; Masahiro Mohri; Kosuke Inokuchi; Akira Ito; Yoji Hirakawa; Akihiro Masumoto; Yoshitaka Hirooka; Akira Takeshita; Hiroaki Shimokawa
Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina.
Journal of cardiovascular pharmacology 2007;49(3):117-21.
2007: Yoji Sagara; Yoshitaka Hirooka; Masatsugu Nozoe; Koji Ito; Yoshikuni Kimura; Kenji Sunagawa
Pressor response induced by central angiotensin II is mediated by activation of Rho/Rho-kinase pathway via AT1 receptors.
Journal of hypertension 2007;25(2):399-406.
2007: Yoshikuni Kimura; Yoshitaka Hirooka; Yoji Sagara; Kenji Sunagawa
Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2007;29(1):13-21.
2006: Koji Ito; Yoshitaka Hirooka; Yoshikuni Kimura; Yoji Sagara; Kenji Sunagawa
Ovariectomy augments hypertension through rho-kinase activation in the brain stem in female spontaneously hypertensive rats.
Hypertension 2006;48(4):651-7.
2006: Yoshitaka Hirooka
Localized gene transfer and its application for the study of central cardiovascular control.
Autonomic neuroscience : basic & clinical 2006;126-127():120-9.
2006: Yoshitaka Hirooka; Yoshikuni Kimura; Masatsugu Nozoe; Yoji Sagara; Koji Ito; Kenji Sunagawa
Amlodipine-induced reduction of oxidative stress in the brain is associated with sympatho-inhibitory effects in stroke-prone spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2006;29(1):49-56.
2005: Koji Ito; Yoshitaka Hirooka; Nobuaki Hori; Yoshikuni Kimura; Yoji Sagara; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Inhibition of rho-kinase in the nucleus tractus solitarius enhances glutamate sensitivity in rats.
Hypertension 2005;46(2):360-5.
2005: Takuya Kishi; Yoshitaka Hirooka; Akihiro Masumoto; Koji Ito; Yoshikuni Kimura; Kosuke Inokuchi; Tatsuya Tagawa; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure.
Circulation 2005;111(21):2741-7.
2005: Yoshitaka Hirooka; Hiroaki Shimokawa
[Perspective of sympathetic nervous system inhibitors].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 3():565-72.
2005: Yoshikuni Kimura; Yoshitaka Hirooka; Yoji Sagara; Koji Ito; Takuya Kishi; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress.
Circulation research 2005;96(2):252-60.
2005: Koji Ito; Yoshitaka Hirooka; Yoshikuni Kimura; Hiroaki Shimokawa; Akira Takeshita
Effects of hydroxyfasudil administered to the nucleus tractus solitarii on blood pressure and heart rate in spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2005;27(2-3):269-77.
2005: Yoshitaka Hirooka; Hiroaki Shimokawa
Therapeutic potential of rho-kinase inhibitors in cardiovascular diseases.
American journal of cardiovascular drugs : drugs, devices, and other interventions 2005;5(1):31-9.
2004: Yoshitaka Hirooka; Hiroaki Shimokawa; Akira Takeshita
Rho-kinase, a potential therapeutic target for the treatment of hypertension.
Drug news & perspectives 2004;17(8):523-7.
2004: Junko Hiroki; Yoshihiro Fukumoto; Hiroaki Shimokawa; Yoshitaka Hirooka; Akira Takeshita
[Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report].
Journal of cardiology 2004;44(4):161-4.
2004: Koji Ito; Yoshitaka Hirooka; Yoji Sagara; Yoshikuni Kimura; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita; Kenji Sunagawa
Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats.
Hypertension 2004;44(4):478-83.
2004: Takuya Kishi; Yoshitaka Hirooka; Yoshikuni Kimura; Koji Ito; Hiroaki Shimokawa; Akira Takeshita
Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.
Circulation 2004;109(19):2357-62.
2004: Yoshitaka Hirooka
Adenovirus-mediated gene transfer into the brain stem to examine cardiovascular function: role of nitric oxide and Rho-kinase.
Progress in biophysics and molecular biology 2004;84(2-3):233-49.
2004: Koji Ito; Yoshitaka Hirooka; Takuya Kishi; Yoshikuni Kimura; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita
Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.
Hypertension 2004;43(2):156-62.
2004: Yoshitaka Hirooka; Koji Sakai
Adenovirus-mediated nitric oxide synthase gene transfer into the nucleus tractus solitarius in conscious rats.
Methods in molecular biology (Clifton, N.J.) 2004;279():187-200.
2004: Yoshitaka Hirooka
[Cardiovascular protective action of Rho-kinase inhibitors].
Nihon rinsho. Japanese journal of clinical medicine 2004;62(1):161-71.
2003: Yoshitaka Hirooka; Hideaki Shigematsu; Takuya Kishi; Yoshikuni Kimura; Yoichi Ueta; Akira Takeshita
Reduced nitric oxide synthase in the brainstem contributes to enhanced sympathetic drive in rats with heart failure.
Journal of cardiovascular pharmacology 2003;42 Suppl 1():S111-5.
2003: Yoshitaka Hirooka; Kenichi Eshima; Soko Setoguchi; Takuya Kishi; Kensuke Egashira; Akira Takeshita
Vitamin C improves attenuated angiotensin II-induced endothelium-dependent vasodilation in human forearm vessels.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(12):953-9.
2003: Kosuke Inokuchi; Yoshitaka Hirooka; Hiroaki Shimokawa; Koji Sakai; Takuya Kishi; Koji Ito; Yoshikuni Kimura; Akira Takeshita
Role of endothelium-derived hyperpolarizing factor in human forearm circulation.
Hypertension 2003;42(5):919-24.
2003: Koji Ito; Yoshitaka Hirooka; Koji Sakai; Takuya Kishi; Kozo Kaibuchi; Hiroaki Shimokawa; Akira Takeshita
Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension.
Circulation research 2003;92(12):1337-43.
2003: Yoshitaka Hirooka; Koji Sakai; Takuya Kishi; Koji Ito; Hiroaki Shimokawa; Akira Takeshita
Enhanced depressor response to endothelial nitric oxide synthase gene transfer into the nucleus tractus solitarii of spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(4):325-31.
2003: Takuya Kishi; Yoshitaka Hirooka; Yoshikuni Kimura; Koji Sakai; Koji Ito; Hiroaki Shimokawa; Akira Takeshita
Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats.
Hypertension 2003;41(2):255-60.
2003: Takuya Kishi; Yoshitaka Hirooka; Yasushi Mukai; Hiroaki Shimokawa; Akira Takeshita
Atorvastatin causes depressor and sympatho-inhibitory effects with upregulation of nitric oxide synthases in stroke-prone spontaneously hypertensive rats.
Journal of hypertension 2003;21(2):379-86.
2003: Yoshitaka Hirooka; Takuya Kishi; Koji Sakai; Hiroaki Shimokawa; Akira Takeshita
Effect of overproduction of nitric oxide in the brain stem on the cardiovascular response in conscious rats.
Journal of cardiovascular pharmacology 2003;41 Suppl 1():S119-26.
2002: Tatsuya Tagawa; Yoshitaka Hirooka; Hiroaki Shimokawa; Kiyoshi Hironaga; Koji Sakai; Jun-ichi Oyama; Akira Takeshita
Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):823-9.
2002: Masahiro Mohri; Toshihiro Ichiki; Yoshitaka Hirooka; Akira Takeshita
Endogenous nitric oxide prevents myocardial ischemia in patients with hypertension and left ventricular hypertrophy.
American heart journal 2002;143(4):684-9.
2002: Soko Setoguchi; Yoshitaka Hirooka; Kenichi Eshima; Hiroaki Shimokawa; Akira Takeshita
Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure.
Journal of cardiovascular pharmacology 2002;39(3):363-8.
2002: Takuya Kishi; Yoshitaka Hirooka; Koji Ito; Koji Sakai; Hiroaki Shimokawa; Akira Takeshita
Cardiovascular effects of overexpression of endothelial nitric oxide synthase in the rostral ventrolateral medulla in stroke-prone spontaneously hypertensive rats.
Hypertension 2002;39(2):264-8.
2001: Akihiro Masumoto; Yoshitaka Hirooka; Hiroaki Shimokawa; Kiyoshi Hironaga; Soko Setoguchi; Akira Takeshita
Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans.
Hypertension 2001;38(6):1307-10.
2001: Akihiro Masumoto; Yoshitaka Hirooka; Kiyoshi Hironaga; Kenichi Eshima; Soko Setoguchi; Kensuke Egashira; Akira Takeshita
Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin).
The American journal of cardiology 2001;88(11):1291-4.
2001: Takuya Kishi; Yoshitaka Hirooka; Koji Sakai; Hideaki Shigematsu; Hiroaki Shimokawa; Akira Takeshita
Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release.
Hypertension 2001;38(4):896-901.
2001: Yoshitaka Hirooka; Koji Sakai; Takuya Kishi; Akira Takeshita
Adenovirus-mediated gene transfer into the NTS in conscious rats. A new approach to examining the central control of cardiovascular regulation.
Annals of the New York Academy of Sciences 2001;940():197-205.
2001: Hideaki Shigematsu; Yoshitaka Hirooka; Kenichi Eshima; Miwako Shihara; Tatsuya Tagawa; Akira Takeshita
Endogenous angiotensin II in the NTS contributes to sympathetic activation in rats with aortocaval shunt.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(6):R1665-73.
2001: Yoshitaka Hirooka; Akira Takeshita
[Recent trends in studies of the etiology of hypertension: Central nervous system and autonomic nervous system].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(5):860-6.
2001: I Matsuo; Yoshitaka Hirooka; Kiyoshi Hironaga; Kenichi Eshima; Hideaki Shigematsu; Miwako Shihara; Koji Sakai; Akira Takeshita
Glutamate release via NO production evoked by NMDA in the NTS enhances hypotension and bradycardia in vivo.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(5):R1285-91.
2001: Miwako Shihara; Yoshitaka Hirooka; Kenichi Eshima; Nobuaki Hori; Akira Takeshita
Stimulatory effect of endothelin-1 on neurons in the nucleus tractus solitarii is mediated by non-N-methyl-D-aspartate receptors.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(2):137-42.
2000: Koji Sakai; Yoshitaka Hirooka; I Matsuo; Kenichi Eshima; Hideaki Shigematsu; Hiroaki Shimokawa; Akira Takeshita
Overexpression of eNOS in NTS causes hypotension and bradycardia in vivo.
Hypertension 2000;36(6):1023-8.
2000: Kenichi Eshima; Yoshitaka Hirooka; Hideaki Shigematsu; I Matsuo; George Koike; Koji Sakai; Akira Takeshita
Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition.
Hypertension 2000;36(2):259-63.
2000: Yoshitaka Hirooka; Akira Takeshita
[Blood pressure regulation by nitric oxide within the brain].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():35-8.
1999: H Tagawa; Hiroaki Shimokawa; Tatsuya Tagawa; M Kuroiwa-Matsumoto; Yoshitaka Hirooka; Akira Takeshita
Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease.
Journal of cardiovascular pharmacology 1999;33(4):633-40.
1999: Miwako Shihara; Nobuaki Hori; Yoshitaka Hirooka; Kenichi Eshima; N Akaike; Akira Takeshita
Cholinergic systems in the nucleus of the solitary tract of rats.
The American journal of physiology 1999;276(4 Pt 2):R1141-8.
1999: Yoshitaka Hirooka; Miwako Shihara; Kenichi Eshima; Nobuaki Hori; Akira Takeshita
Endothelin-1 facilitates synaptic transmission in the nucleus tractus solitarii in normotensive rats but not in spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 1999;22(1):43-8.
1998: Miwako Shihara; Yoshitaka Hirooka; Nobuaki Hori; I Matsuo; Tatsuya Tagawa; S Suzuki; N Akaike; Akira Takeshita
Endothelin-1 increases the neuronal activity and augments the responses to glutamate in the NTS.
The American journal of physiology 1998;275(2 Pt 2):R658-65.
1998: Kiyoshi Hironaga; Yoshitaka Hirooka; I Matsuo; Miwako Shihara; Tatsuya Tagawa; Yasuhiko Harasawa; Akira Takeshita
Role of endogenous nitric oxide in the brain stem on the rapid adaptation of baroreflex.
Hypertension 1998;31(1):27-31.
1997: H Tagawa; Hiroaki Shimokawa; Tatsuya Tagawa; M Kuroiwa-Matsumoto; Yoshitaka Hirooka; Akira Takeshita
Short-term estrogen augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilation in postmenopausal women.
Journal of cardiovascular pharmacology 1997;30(4):481-8.
1997: Tatsuya Tagawa; Masahiro Mohri; H Tagawa; Kensuke Egashira; Hiroaki Shimokawa; T Kuga; Yoshitaka Hirooka; Akira Takeshita
Role of nitric oxide in substance P-induced vasodilation differs between the coronary and forearm circulation in humans.
Journal of cardiovascular pharmacology 1997;29(4):546-53.
1997: M Shiramoto; T Imaizumi; Yoshitaka Hirooka; T Endo; T Namba; Jun-ichi Oyama; Kiyoshi Hironaga; Akira Takeshita
Role of nitric oxide towards vasodilator effects of substance P and ATP in human forearm vessels.
Clinical science (London, England : 1979) 1997;92(2):123-31.
1996: Akira Takeshita; Yoshitaka Hirooka; T Imaizumi
Role of endothelium in control of forearm blood flow in patients with heart failure.
Journal of cardiac failure 1996;2(4 Suppl):S209-15.
1996: Kensuke Egashira; Yoshitaka Hirooka; T Kuga; Masahiro Mohri; Akira Takeshita
Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms.
Circulation 1996;94(2):130-4.
1995: Kensuke Egashira; S Suzuki; Yoshitaka Hirooka; H Kai; M Sugimachi; T Imaizumi; Akira Takeshita
Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension. Different responses to acetylcholine and substance P.
Hypertension 1995;25(2):201-6.
1994: H Kai; Kensuke Egashira; Yoshitaka Hirooka; M Sugimachi; Shigeharu Suzuki; T Kuga; K Mohri; Yoshitoshi Urabe; T Inou; Akira Takeshita
Effects of intracoronary infusion of atrial natriuretic peptide on pacing-induced myocardial ischemia in patients with effort angina pectoris.
Coronary artery disease 1994;5(12):987-94.
1994: Yoshitaka Hirooka; Kensuke Egashira; T Imaizumi; Tatsuya Tagawa; H Kai; M Sugimachi; Akira Takeshita
Effect of L-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humans.
Journal of the American College of Cardiology 1994;24(4):948-55.
1994: Yoshitaka Hirooka; T Imaizumi; Tatsuya Tagawa; M Shiramoto; T Endo; S Ando; Akira Takeshita
Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure.
Circulation 1994;90(2):658-68.
1994: Tatsuya Tagawa; T Imaizumi; S Harada; T Endo; M Shiramoto; Yoshitaka Hirooka; Akira Takeshita
Nitric oxide influences neuronal activity in the nucleus tractus solitarius of rat brainstem slices.
Circulation research 1994;75(1):70-6.
1994: Kensuke Egashira; Yoshitaka Hirooka; H Kai; M Sugimachi; Shigeharu Suzuki; T Inou; Akira Takeshita
Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.
Circulation 1994;89(6):2519-24.
1994: S Ando; T Imaizumi; S Harada; Shigeharu Suzuki; M Sugimachi; K Sunagawa; Yoshitaka Hirooka; Akira Takeshita
Postganglionic sympathetic nerve discharges can contain both central and pulse-related oscillations simultaneously in rabbits.
Journal of the autonomic nervous system 1994;47(3):189-99.
1993: Tatsuya Tagawa; T Imaizumi; T Endo; M Shiramoto; Yoshitaka Hirooka; S Ando; Akira Takeshita
Vasodilatory effect of arginine vasopressin is mediated by nitric oxide in human forearm vessels.
The Journal of clinical investigation 1993;92(3):1483-90.
1993: Kensuke Egashira; T Inou; Yoshitaka Hirooka; H Kai; M Sugimachi; Shigeharu Suzuki; T Kuga; Yoshitoshi Urabe; Akira Takeshita
Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans.
Circulation 1993;88(1):77-81.
1993: Kensuke Egashira; T Inou; Yoshitaka Hirooka; A Yamada; Yoshitoshi Urabe; Akira Takeshita
Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms.
The New England journal of medicine 1993;328(23):1659-64.
1993: H Masaki; T Imaizumi; S Harada; M Momohara; Yoshitaka Hirooka; Akira Takeshita
Effects of a novel orally effective V1-receptor antagonist, OPC-21268, on AVP-induced sympathoinhibition.
The American journal of physiology 1993;264(6 Pt 2):R1089-94.
1993: H Masaki; T Imaizumi; S Ando; Yoshitaka Hirooka; S Harada; M Momohara; M Nagano; Akira Takeshita
Production of chronic congestive heart failure by rapid ventricular pacing in the rabbit.
Cardiovascular research 1993;27(5):828-31.
1993: T Imaizumi; M Sugimachi; Yasuhiko Harasawa; S Ando; K Sunagawa; Yoshitaka Hirooka; Akira Takeshita
Contribution of wall mechanics to the dynamic properties of aortic baroreceptors.
The American journal of physiology 1993;264(3 Pt 2):H872-80.
1993: Kensuke Egashira; T Inou; Yoshitaka Hirooka; A Yamada; Y Maruoka; H Kai; M Sugimachi; Shigeharu Suzuki; Akira Takeshita
Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions.
The Journal of clinical investigation 1993;91(1):29-37.
1992: T Imaizumi; Yoshitaka Hirooka; H Masaki; S Harada; M Momohara; Tatsuya Tagawa; Akira Takeshita
Effects of L-arginine on forearm vessels and responses to acetylcholine.
Hypertension 1992;20(4):511-7.
1992: Yoshitaka Hirooka; T Imaizumi; M Sugimachi; Akira Takeshita
Mechanisms involved in aortic baroreceptor excitation during drug-induced aortic pressure elevation in intact rabbits.
Journal of the autonomic nervous system 1992;40(2):99-106.
1992: S Harada; T Imaizumi; S Ando; Yoshitaka Hirooka; K Sunagawa; Akira Takeshita
Arterial baroreflex dynamics in normotensive and spontaneously hypertensive rats.
The American journal of physiology 1992;263(3 Pt 2):R524-8.
1992: Yoshitaka Hirooka; T Imaizumi; H Masaki; S Ando; S Harada; M Momohara; Akira Takeshita
Captopril improves impaired endothelium-dependent vasodilation in hypertensive patients.
Hypertension 1992;20(2):175-80.
1992: T Imaizumi; S Harada; Yoshitaka Hirooka; H Masaki; M Momohara; Akira Takeshita
Effects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in humans.
Hypertension 1992;20(1):54-8.
1992: T Imaizumi; Yoshitaka Hirooka; Akira Takeshita
Decreased skeletal muscle vasodilation in patients with congestive heart failure.
Japanese circulation journal 1992;56(5):500-3.
1992: S Ando; T Imaizumi; S Harada; Yoshitaka Hirooka; Akira Takeshita
Atrial natriuretic peptide increases human capillary filtration and venous distensibility.
Journal of hypertension 1992;10(5):451-7.
1992: Kensuke Egashira; T Inou; A Yamada; Yoshitaka Hirooka; Akira Takeshita
Preserved endothelium-dependent vasodilation at the vasospastic site in patients with variant angina.
The Journal of clinical investigation 1992;89(3):1047-52.
1992: Yoshitaka Hirooka; T Imaizumi; S Harada; H Masaki; M Momohara; Tatsuya Tagawa; Akira Takeshita
Endothelium-dependent forearm vasodilation to acetylcholine but not to substance P is impaired in patients with heart failure.
Journal of cardiovascular pharmacology 1992;20 Suppl 12():S221-5.
1991: S Harada; S Ando; T Imaizumi; Yoshitaka Hirooka; K Sunagawa; Akira Takeshita
Arterial baroreflex control of cardiac and renal sympathetic nerve activities is uniform in frequency domain.
The American journal of physiology 1991;261(2 Pt 2):R296-300.
1991: Yoshitaka Hirooka; S Ando; T Imaizumi; Shigeharu Suzuki; Akira Takeshita
Exogenous prostacyclin does not sensitize arterial baroreceptors.
The American journal of physiology 1991;260(6 Pt 2):H1760-6.
1991: M Yoshida; T Imaizumi; S Ando; Yoshitaka Hirooka; S Harada; Akira Takeshita
Impaired forearm vasodilatation by acetylcholine in patients with hypertension.
Heart and vessels 1991;6(4):218-23.
1990: T Imaizumi; Akira Takeshita; N Nakamura; K Sakai; Yoshitaka Hirooka; S Suzuki; M Yoshida; M Nakamura
Effects of captopril on forearm oxygen consumption during dynamic handgrip exercise in patients with congestive heart failure.
Japanese heart journal 1990;31(6):817-28.
1990: Yoshitaka Hirooka; Akira Takeshita; T Imaizumi; Shigeharu Suzuki; M Yoshida; S Ando; M Nakamura
Attenuated forearm vasodilative response to intra-arterial atrial natriuretic peptide in patients with heart failure.
Circulation 1990;82(1):147-53.
1990: M Sugimachi; T Imaizumi; K Sunagawa; Yoshitaka Hirooka; K Todaka; Akira Takeshita; M Nakamura
A new method to identify dynamic transduction properties of aortic baroreceptors.
The American journal of physiology 1990;258(3 Pt 2):H887-95.
1990: T Imaizumi; Akira Takeshita; M Yoshida; Shigeharu Suzuki; S Ando; Yoshitaka Hirooka; M Nakamura
Different effects of alpha-human atrial natriuretic peptide and nitroglycerin on cardiac dimensions in humans.
Heart and vessels 1990;5(2):87-92.
1989: Shigeharu Suzuki; Akira Takeshita; T Imaizumi; Yoshitaka Hirooka; M Yoshida; S Ando; M Nakamura
Central nervous system mechanisms involved in inhibition of renal sympathetic nerve activity induced by arginine vasopressin.
Circulation research 1989;65(5):1390-9.
1989: Shigeharu Suzuki; Akira Takeshita; T Imaizumi; Yoshitaka Hirooka; M Yoshida; S Ando; M Nakamura
Biphasic forearm vascular responses to intraarterial arginine vasopressin.
The Journal of clinical investigation 1989;84(2):427-34.
1989: Shigeharu Suzuki; Akira Takeshita; T Imaizumi; Yoshitaka Hirooka; M Yoshida; M Nakamura
Evidence against the central nervous system being involved in altered reflex control of sympathetic nerve activity by atrial natriuretic peptide.
Brain research 1989;485(1):109-14.
1988: Yoshitaka Hirooka; Akira Takeshita; T Imaizumi; N Nakamura; H Tomoike; M Nakamura
Effects of alpha-human atrial natriuretic peptide on the interrelationship of arterial pressure, aortic nerve activity, and aortic diameter.
Circulation research 1988;63(6):987-96.
1988: T Imaizumi; Akira Takeshita; N Nakamura; Yoshitaka Hirooka; Shigeharu Suzuki; M Yoshida; M Nakamura
Vasodilating effect of the new beta-blocker tilisolol hydrochloride in humans.
Arzneimittel-Forschung 1988;38(9):1342-4.
1988: Yoshitaka Hirooka; Yoshitoshi Urabe; T Imaizumi; Akira Takeshita; T Tajimi; S Koyanagi; M Nakamura
The usefulness of equilibrium radionuclide ventriculography in the diagnosis of arrhythmogenic right ventricular dysplasia and a report of cases of a familial occurrence.
Japanese circulation journal 1988;52(6):511-7.
1988: Shigeharu Suzuki; Akira Takeshita; T Imaizumi; Yoshitaka Hirooka; M Yoshida; M Nakamura
Evidence against the central nervous system involved in altered reflex control of sympathetic nerve activity by atrial natriuretic peptide.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10 Suppl 1():263-8.