FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jon Aster

Research Profile

Chemicals & Drugs

Physiology

Living Beings

Mouse

Disorders

Adult T Cell Leukemia Lymphoma

Anatomy

Concepts & Ideas

Procedures

Bone Marrow Transplantation

Co-author Network

Publications

TOP 3
Giovanni Roti; Angela H Su; Jon C Aster; Stephen C Blacklow; Anne Carlton; Andrew L Kung; Michele Markstein; Kostandin Pajcini; Warren S Pear; Norbert Perrimon; Kenneth N Ross; Kimberly Stegmaier
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
Jon C Aster; Daniel J DeAngelo
Resistance revealed in acute lymphoblastic leukemia.
Mark Y Chiang; Olga Shestova; Lanwei Xu; Jon C Aster; Warren S Pear
Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jon Aster (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Giovanni Roti; Angela H Su; Jon C Aster; Stephen C Blacklow; Anne Carlton; Andrew L Kung; Michele Markstein; Kostandin Pajcini; Warren S Pear; Norbert Perrimon; Kenneth N Ross; Kimberly Stegmaier
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
Cancer cell 2013;23(3):390-405.
2013: Jon C Aster; Daniel J DeAngelo
Resistance revealed in acute lymphoblastic leukemia.
Nature medicine 2013;19(3):264-5.
2013: Mark Y Chiang; Olga Shestova; Lanwei Xu; Jon C Aster; Warren S Pear
Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells.
Blood 2013;121(6):905-17.
2012: Jon C Aster; Stephen C Blacklow
Targeting the Notch pathway: twists and turns on the road to rational therapeutics.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(19):2418-20.
2012: Min Jie Alvin Tan; Elizabeth A White; Jon C Aster; J Wade Harper; Mathew E Sowa; Peter M Howley
Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(23):E1473-80.
2012: Versha Banerji; Kwan T Chow; Daniel J DeAngelo; Stacey M Frumm; Ilene Galinsky; Cynthia K Hahn; William C Hahn; Haig Inguilizian; Rose M Kakoza; Andrew L Kung; Loretta S Li; Kenneth N Ross; Linda Ross; Giovanni Roti; Anna C Schinzel; Gabriela Alexe; Jon C Aster; Richard M Stone; Nicola Tolliday; Kimberly Stegmaier
The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia.
The Journal of clinical investigation 2012;122(3):935-47.
2011: Bo Zhao; James Zou; Jon C Aster; Bradley E Bernstein; Stephen C Blacklow; Matthew L Freedman; Eric Johannsen; Jessica C Mar; Cynthia Casson Morton; Chih-Wen Peng; John Quackenbush; Hongfang Wang; Elliott Kieff
Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(36):14902-7.
2011: Hongfang Wang; Hoifung Wong; Bo Zhao; James Zou; Bradley E Bernstein; Stephen C Blacklow; Eric Johannsen; Elliott Kieff; Warren S Pear; Jonathan Schug; Kelly L Arnett; Todd Ashworth; Jon C Aster
Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(36):14908-13.
2011: Hind Medyouf; Oksana Nemirovsky; Francoise Pflumio; Michael Pollak; Andreas Trumpp; Jen-Chieh Tseng; Carol Wai; Hongfang Wang; Jon C Aster; Joan Carboni; Marco Gottardis; Samuel Gusscott; Martin Holzenberger; Andrew L Kung; Andrew P Weng
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.
The Journal of experimental medicine 2011;208(9):1809-22.
2011: Melanie G Cornejo; Ronald A DePinho; D Gary Gilliland; Tulasi Khandan; Cristina Lo Celso; Cécile K Lopez; Vinciane Mabialah; Philippe Rameau; Paola Rivera-Muñoz; David T Scadden; Stephen M Sykes; Zuzana Tothova; Jon C Aster; Thomas Mercher
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Blood 2011;118(5):1264-73.
2011: Jon C Aster; Stephen C Blacklow; Nick Bodnar; Gavin Histen; Fredrick G Karnell; Ivan P Maillard; John M Milholland; Yunsun Nam; Lanwei Xu; Warren S Pear
Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.
PloS one 2011;6(10):e25645.
2011: Jon C Aster; Stephen C Blacklow; Warren S Pear
Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.
The Journal of pathology 2011;223(2):262-73.
2010: Todd D Ashworth; Warren S Pear; Mark Chiang; Stephen C Blacklow; Jérôme Mastio; Lanwei Xu; Michelle A Kelliher; Philippe Kastner; Susan Chan; Jon C Aster
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.
Blood 2010;116(25):5455-64.
2010: Nitin Roper; Daniel J DeAngelo; Frank Kuo; Paola Dal Cin; Irene M Ghobrial; Jon C Aster
An asymptomatic 61-year-old man with BCR-ABL-positive bone marrow following autologous transplantation for multiple myeloma.
American journal of hematology 2010;85(12):944-6.
2010: Hudan Liu; Anthony W S Chi; Kelly L Arnett; Mark Y Chiang; Lanwei Xu; Olga Shestova; Hongfang Wang; Yue-Ming Li; Avinash Bhandoola; Jon C Aster; Stephen C Blacklow; Warren S Pear
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development 2010;24(21):2395-407.
2010: Marco Mazzone; Laura M Selfors; John Albeck; Michael Overholtzer; Sanja Sale; Danielle L Carroll; Darshan Pandya; Yiling Lu; Gordon B Mills; Jon C Aster; Spyros Artavanis-Tsakonas; Joan S Brugge
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(11):5012-7.
2010: Akinori Yoda; Yuka Yoda; Sabina Chiaretti; Michal Bar-Natan; Kartik Mani; Scott J Rodig; Nathan West; Yun Xiao; Jennifer R Brown; Constantine Mitsiades; Martin Sattler; Jeffery L Kutok; Daniel J DeAngelo; Martha Wadleigh; Alfonso Piciocchi; Paola Dal Cin; James E Bradner; James D Griffin; Kenneth C Anderson; Richard M Stone; Jerome Ritz; Robin Foà; Jon C Aster; David A Frank; David M Weinstock
Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(1):252-7.
2009: Jon C Aster
Notch targeting 2.0.
Blood 2009;113(24):6044-5.
2009: Wendy R. Gordon; Monideepa Roy; Didem Vardar; Megan Garfinkel; Marc R Mansour; Jon C Aster; Stephen C Blacklow
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL.
Blood 2009;113(18):4381-90.
2009: Melanie G Cornejo; Michael G Kharas; Miriam B Werneck; Séverine Le Bras; Sandra A Moore; Brian Ball; Marie Beylot-Barry; Scott J Rodig; Jon C Aster; Benjamin H Lee; Harvey Cantor; Jean-Philippe Merlio; D Gary Gilliland; Thomas Mercher
Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.
Blood 2009;113(12):2746-54.
2009: Wendy R. Gordon; Didem Vardar; Sarah L'Heureux; Todd Ashworth; Michael J Malecki; Cheryll Sanchez-Irizarry; Debbie G McArthur; Gavin Histen; Jennifer L Mitchell; Jon C Aster; Stephen C Blacklow
Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
PloS one 2009;4(8):e6613.
2008: Jennifer L Poitras; Paola Dal Cin; Jon C Aster; Daniel J DeAngelo; Cynthia C Morton
Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia.
Genes, chromosomes & cancer 2008;47(10):884-9.
2008: Thomas Mercher; Melanie G Cornejo; Christopher Sears; Thomas Kindler; Sandra A Moore; Ivan P Maillard; Warren S Pear; Jon C Aster; D Gary Gilliland
Notch signaling specifies megakaryocyte development from hematopoietic stem cells.
Cell stem cell 2008;3(3):314-26.
2008: Mark Chiang; Lanwei Xu; Olga Shestova; Gavin Histen; Sarah L'heureux; Candice Romany; M Eden Childs; Phyllis A Gimotty; Jon C Aster; Warren S Pear
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
The Journal of clinical investigation 2008;118(9):3181-94.
2008: Edward B Stelow; Andrew Bellizzi; Krishan Taneja; Stacey E Mills; Robin D LeGallo; Jeffery L Kutok; Jon C Aster; Christopher A French
NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract.
The American journal of surgical pathology 2008;32(6):828-34.
2008: Ivan P Maillard; Ute Koch; Alexis Dumortier; Olga Shestova; Lanwei Xu; Hong Sai; Seth E Pross; Jon C Aster; Avinash Bhandoola; Freddy Radtke; Warren S Pear
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells.
Cell stem cell 2008;2(4):356-66.
2008: Christopher A French; C L Ramirez; J Kolmakova; T T Hickman; M J Cameron; M E Thyne; Jeffery L Kutok; Jeffrey A Toretsky; A K Tadavarthy; U R Kees; Jonathan A Fletcher; Jon C Aster
BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.
Oncogene 2008;27(15):2237-42.
2008: Kang Li; Yucheng Li; Wenjuan Wu; Wendy R. Gordon; David W Chang; Mason Lu; Shane Scoggin; Tihui Fu; Long Vien; Gavin Histen; Ji Zheng; Rachel Martin-Hollister; Thomas Duensing; Sanjaya Singh; Stephen C Blacklow; Zhengbin Yao; Jon C Aster; Bin-Bing S Zhou
Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3.
The Journal of biological chemistry 2008;283(12):8046-54.
2008: Cristina Del Bianco; Jon C Aster; Stephen C Blacklow
Mutational and energetic studies of Notch 1 transcription complexes.
Journal of molecular biology 2008;376(1):131-40.
2008: Scott J Rodig; Ethan G Payne; Barbara A Degar; Barrett J Rollins; Andrew L Feldman; Elaine S Jaffe; Arlene Androkites; Lewis B Silverman; Janina A Longtine; Jeffery L Kutok; Mark D Fleming; Jon C Aster
Aggressive Langerhans cell histiocytosis following T-ALL: clonally related neoplasms with persistent expression of constitutively active NOTCH1.
American journal of hematology 2008;83(2):116-21.
2008: Kunihiko Takeyama; S Monti; John P Manis; P Dal Cin; Gad Getz; Rameen Beroukhim; Shilpee Dutt; Jon C Aster; Frederick W Alt; Todd R Golub; Margaret A Shipp
Integrative analysis reveals 53BP1 copy loss and decreased expression in a subset of human diffuse large B-cell lymphomas.
Oncogene 2008;27(3):318-22.
2008: Jon C Aster; Warren S Pear; Stephen C Blacklow
Notch signaling in leukemia.
Annual review of pathology 2008;3():587-613.
2007: Steven M Chan; Andrew P Weng; Robert Tibshirani; Jon C Aster; Paul J Utz
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.
Blood 2007;110(1):278-86.
2007: Erik Fung; Sai-Man Timothy Tang; James P Canner; Kunio Morishige; Joseph F Arboleda-Velasquez; Angelo A Cardoso; Nadia Carlesso; Jon C Aster; Masanori Aikawa
Delta-like 4 induces notch signaling in macrophages: implications for inflammation.
Circulation 2007;115(23):2948-56.
2007: Michael J Robertson; Brad S Kahl; Julie M Vose; Sven de Vos; Mary Laughlin; Patrick J Flynn; Kendrith M Rowland; Jose C Cruz; Stuart L Goldberg; Luna Musib; Christelle Darstein; Nathan Enas; Jeffery L Kutok; Jon C Aster; Donna Neuberg; Kerry J Savage; Ann S LaCasce; Donald Thornton; Christopher A Slapak; Margaret A Shipp
Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(13):1741-6.
2007: Wendy R. Gordon; Didem Vardar; Gavin Histen; Cheryll Sanchez-Irizarry; Jon C Aster; Stephen C Blacklow
Structural basis for autoinhibition of Notch.
Nature structural & molecular biology 2007;14(4):295-300.
2007: J Chen; Cicely Jette; John P Kanki; Jon C Aster; A Thomas Look; James D Griffin
NOTCH1-induced T-cell leukemia in transgenic zebrafish.
Leukemia 2007;21(3):462-71.
2007: Yunsun Nam; Piotr Sliz; Warren S Pear; Jon C Aster; Stephen C Blacklow
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2103-8.
2007: Monideepa Roy; Warren S Pear; Jon C Aster
The multifaceted role of Notch in cancer.
Current opinion in genetics & development 2007;17(1):52-9.
2007: Jennifer L Shepard; James F Amatruda; David Finkelstein; James Ziai; K Rose Finley; Howard M Stern; Ken Chiang; Candace Hersey; Bruce Barut; Jennifer L Freeman; Charles Lee; Jonathan N Glickman; Jeffery L Kutok; Jon C Aster; Leonard I Zon
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
Genes & development 2007;21(1):55-9.
2006: Teresa Palomero; Wei Keat Lim; Duncan T Odom; Maria Luisa Sulis; Pedro J Real; Adam A Margolin; Kelly C Barnes; Jennifer O'Neil; Donna Neuberg; Andrew P Weng; Jon C Aster; François Sigaux; Jean Soulier; A Thomas Look; Richard A Young; Andrea Califano; Adolfo Ferrando
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18261-6.
2006: Karen Keeshan; Yiping He; Bas J Wouters; Olga Shestova; Lanwei Xu; Hong Sai; Carlos G Rodriguez; Ivan P Maillard; John W Tobias; Peter J M Valk; Martin Carroll; Jon C Aster; Ruud Delwel; Warren S Pear
Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia.
Cancer cell 2006;10(5):401-11.
2006: Teresa Palomero; K McKenna; J O-Neil; Ilene Galinsky; R Stone; K Suzukawa; E Stiakaki; M Kalmanti; Edward A Fox; M A Caligiuri; Jon C Aster; A Thomas Look; Adolfo Ferrando
Activating mutations in NOTCH1 in acute myeloid leukemia and lineage switch leukemias.
Leukemia 2006;20(11):1963-6.
2006: Mark Y Chiang; Mina L Xu; Gavin Histen; Olga Shestova; Monideepa Roy; Yunsun Nam; Stephen C Blacklow; David B Sacks; Warren S Pear; Jon C Aster
Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1.
Molecular and cellular biology 2006;26(16):6261-71.
2006: Andrew P Weng; John M Millholland; Yumi Yashiro-ohtani; Marie Laure Arcangeli; Arthur Lau; Carol Wai; Cristina Del Bianco; Carlos G Rodriguez; Hong Sai; John Tobias; Yueming Li; Michael S Wolfe; Cathy Shachaf; Dean W Felsher; Stephen C Blacklow; Warren S Pear; Jon C Aster
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Genes & development 2006;20(15):2096-109.
2006: Hidenobu Takahashi; Friedrich Feuerhake; Jeffery L Kutok; Stefano Monti; Paola Dal Cin; Donna Neuberg; Jon C Aster; Margaret A Shipp
FAS death domain deletions and cellular FADD-like interleukin 1beta converting enzyme inhibitory protein (long) overexpression: alternative mechanisms for deregulating the extrinsic apoptotic pathway in diffuse large B-cell lymphoma subtypes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(11 Pt 1):3265-71.
2006: Michael J Malecki; Cheryll Sanchez-Irizarry; Jennifer L Mitchell; Gavin Histen; Mina L Xu; Jon C Aster; Stephen C Blacklow
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes.
Molecular and cellular biology 2006;26(12):4642-51.
2006: Yunsun Nam; Piotr Sliz; Luyan Song; Jon C Aster; Stephen C Blacklow
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Cell 2006;124(5):973-83.
2006: Laura Pasqualucci; Mara Compagno; Jane Houldsworth; Stefano Monti; Adina Grunn; Subhadra V Nandula; Jon C Aster; Vundavalli Murty; Margaret A Shipp; Riccardo Dalla-Favera
Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma.
The Journal of experimental medicine 2006;203(2):311-7.
2006: Hidenobu Takahashi; Friedrich Feuerhake; Stefano Monti; Jeffery L Kutok; Jon C Aster; Margaret A Shipp
Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma.
Blood 2006;107(2):844-5.
2006: Jennifer O'Neil; Jennifer Calvo; Keith McKenna; Veena Krishnamoorthy; Jon C Aster; Craig H Bassing; Frederick W Alt; Michelle A Kelliher; A Thomas Look
Activating Notch1 mutations in mouse models of T-ALL.
Blood 2006;107(2):781-5.
2005: Patrick A Zweidler-McKay; Yiping He; Lanwei Xu; Carlos G Rodriguez; Fredrick G Karnell; Andrea C Carpenter; Jon C Aster; David Allman; Warren S Pear
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
Blood 2005;106(12):3898-906.
2005: Jon C Aster
Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities.
International journal of hematology 2005;82(4):295-301.
2005: Jennifer L Shepard; James F Amatruda; Howard M Stern; Aravind Subramanian; David Finkelstein; James Ziai; K Rose Finley; Kathleen L Pfaff; Candace Hersey; Yi Zhou; Bruce Barut; Matthew Freedman; Charles Lee; Jan Spitsbergen; Donna Neuberg; Gerhard Weber; Todd R Golub; Jonathan N Glickman; Jeffery L Kutok; Jon C Aster; Leonard I Zon
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(37):13194-9.
2005: Friedrich Feuerhake; Jeffery L Kutok; Stefano Monti; Wen Chen; Ann S LaCasce; Giorgio Cattoretti; Paul Kurtin; Geraldine S Pinkus; Laurence de Leval; Nancy Lee Harris; Kerry J Savage; Donna Neuberg; Thomas M Habermann; Riccardo Dalla-Favera; Todd R Golub; Jon C Aster; Margaret A Shipp
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes.
Blood 2005;106(4):1392-9.
2005: Arivazhagan Sambandam; Ivan P Maillard; Valerie P Zediak; Lanwei Xu; Rachel M Gerstein; Jon C Aster; Warren S Pear; Avinash Bhandoola
Notch signaling controls the generation and differentiation of early T lineage progenitors.
Nature immunology 2005;6(7):663-70.
2005: Stefano Monti; Kerry J Savage; Jeffery L Kutok; Friedrich Feuerhake; Paul Kurtin; Martin Mihm; Bingyan Wu; Laura Pasqualucci; Donna Neuberg; Ricardo Aguiar; Paola Dal Cin; Christine Ladd; Geraldine S Pinkus; Gilles SALLES; Nancy Lee Harris; Riccardo Dalla-Favera; Thomas M Habermann; Jon C Aster; Todd R Golub; Margaret A Shipp
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response.
Blood 2005;105(5):1851-61.
2005: E Elizabeth Patton; Hans R Widlund; Jeffery L Kutok; Kamden R Kopani; James F Amatruda; Ryan D Murphey; Stephane Berghmans; Elizabeth A Mayhall; David Traver; Christopher D M Fletcher; Jon C Aster; Scott R Granter; A Thomas Look; Charles Lee; David E Fisher; Leonard I Zon
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.
Current biology : CB 2005;15(3):249-54.
2005: Scott J Rodig; Kerry J Savage; Vuong Nguyen; Geraldine S Pinkus; Margaret A Shipp; Jon C Aster; Jeffery L Kutok
TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar lymphomas.
The American journal of surgical pathology 2005;29(2):196-203.
2004: Warren S Pear; Jon C Aster
T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling.
Current opinion in hematology 2004;11(6):426-33.
2004: Cheryll Sanchez-Irizarry; Andrea C Carpenter; Andrew P Weng; Warren S Pear; Jon C Aster; Stephen C Blacklow
Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats.
Molecular and cellular biology 2004;24(21):9265-73.
2004: Christopher A French; Jeffery L Kutok; William C Faquin; Jeffrey A Toretsky; Cristina R Antonescu; Constance A Griffin; Vania Nose; Sara O Vargas; Maria Moschovi; Fotini Tzortzatou-Stathopoulou; Isao Miyoshi; Antonio R Perez-Atayde; Jon C Aster; Jonathan A Fletcher
Midline carcinoma of children and young adults with NUT rearrangement.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(20):4135-9.
2004: Andrew P Weng; Adolfo Ferrando; Woojoong Lee; John P Morris; Lewis B Silverman; Cheryll Sanchez-Irizarry; Stephen C Blacklow; A Thomas Look; Jon C Aster
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science (New York, N.Y.) 2004;306(5694):269-71.
2004: Sandro Santagata; Francesca Demichelis; Alberto Riva; Sooryanarayana Lnu; Matthias D Hofer; Jeffery L Kutok; Robert Kim; Jeffery Tang; James E Montie; Arul M Chinnaiyan; Mark A Rubin; Jon C Aster
JAGGED1 expression is associated with prostate cancer metastasis and recurrence.
Cancer research 2004;64(19):6854-7.
2004: Ivan P Maillard; Andrew P Weng; Andrea C Carpenter; Carlos G Rodriguez; Hong Sai; Lanwei Xu; David Allman; Jon C Aster; Warren S Pear
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.
Blood 2004;104(6):1696-702.
2004: Pierre Rivailler; Angela Carville; Amitinder Kaur; Pasupuleti Rao; Carol Quink; Jeffery L Kutok; Susan Westmoreland; Sherry Klumpp; Meredith Simon; Jon C Aster; Fred Wang
Experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for Epstein-Barr virus pathogenesis in the immunosuppressed host.
Blood 2004;104(5):1482-9.
2004: Indranil Das; Colleen Craig; Yasuhiro Funahashi; Kwang-Mook Jung; TAE-WAN KIM; Richard Byers; Andrew P Weng; Jeffery L Kutok; Jon C Aster; Jan Kitajewski
Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.
The Journal of biological chemistry 2004;279(29):30771-80.
2004: Jeffery L Kutok; Sherry Klumpp; Meredith Simon; John J MacKey; Vuong Nguyen; Jaap Middeldorp; Jon C Aster; Fred Wang
Molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques.
Journal of virology 2004;78(7):3455-61.
2004: Andrew P Weng; Jon C Aster
Multiple niches for Notch in cancer: context is everything.
Current opinion in genetics & development 2004;14(1):48-54.
2003: Andrew P Weng; Jon C Aster
No T without D3: a critical role for cyclin D3 in normal and malignant precursor T cells.
Cancer cell 2003;4(6):417-8.
2003: Kerry J Savage; Stefano Monti; Jeffery L Kutok; Giorgio Cattoretti; Donna Neuberg; Laurence De Leval; Paul Kurtin; Paola Dal Cin; Christine Ladd; Friedrich Feuerhake; Ricardo Aguiar; Sigui Li; Gilles SALLES; Francoise Berger; Wen Jing; Geraldine S Pinkus; Thomas M Habermann; Riccardo Dalla-Favera; Nancy Lee Harris; Jon C Aster; Todd R Golub; Margaret A Shipp
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.
Blood 2003;102(12):3871-9.
2003: Kathryn Wilkinson; Elvira R P Velloso; Luiz Fernando Lopes; Charles Lee; Jon C Aster; Margaret A Shipp; Ricardo Aguiar
Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib.
Blood 2003;102(12):4187-90.
2003: Nahid G Robertson; S A Hamaker; Vytas Patriub; Jon C Aster; Cynthia C Morton
Subcellular localisation, secretion, and post-translational processing of normal cochlin, and of mutants causing the sensorineural deafness and vestibular disorder, DFNA9.
Journal of medical genetics 2003;40(7):479-86.
2003: Didem Vardar; Christopher L North; Cheryll Sanchez-Irizarry; Jon C Aster; Stephen C Blacklow
Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1.
Biochemistry 2003;42(23):7061-7.
2003: Kunihiko Takeyama; Ricardo Aguiar; Liqun Gu; Chunyan He; Gordon J Freeman; Jeffery L Kutok; Jon C Aster; Margaret A Shipp
The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.
The Journal of biological chemistry 2003;278(24):21930-7.
2003: Yunsun Nam; Andrew P Weng; Jon C Aster; Stephen C Blacklow
Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.
The Journal of biological chemistry 2003;278(23):21232-9.
2003: David M Langenau; David Traver; Adolfo Ferrando; Jeffery L Kutok; Jon C Aster; John P Kanki; Shuo Lin; Ed Prochownik; Nikolaus S Trede; Leonard I Zon; A Thomas Look
Myc-induced T cell leukemia in transgenic zebrafish.
Science (New York, N.Y.) 2003;299(5608):887-90.
2003: Andrew P Weng; Yunsun Nam; Michael S Wolfe; Warren S Pear; James D Griffin; Stephen C Blacklow; Jon C Aster
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.
Molecular and cellular biology 2003;23(2):655-64.
2002: Eric J Allenspach; Ivan P Maillard; Jon C Aster; Warren S Pear
Notch signaling in cancer.
Cancer biology & therapy 2002;1(5):466-76.
2002: David Allman; Jon C Aster; Warren S Pear
Notch signaling in hematopoiesis and early lymphocyte development.
Immunological reviews 2002;187():75-86.
2002: Jeffery L Kutok; Jon C Aster
Molecular biology of anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(17):3691-702.
2002: Yunsun Nam; Jon C Aster; Stephen C Blacklow
Notch signaling as a therapeutic target.
Current opinion in chemical biology 2002;6(4):501-9.
2002: Ryan P Million; Jon C Aster; D Gary Gilliland; Richard A Van Etten
The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice.
Blood 2002;99(12):4568-77.
2002: David Allman; Jennifer A Punt; David J Izon; Jon C Aster; Warren S Pear
An invitation to T and more: notch signaling in lymphopoiesis.
Cell 2002;109 Suppl():S1-11.
2002: Jon C Aster; Janina A Longtine
Detection of BCL2 rearrangements in follicular lymphoma.
The American journal of pathology 2002;160(3):759-63.
2002: David J Izon; Jon C Aster; Yiping He; Andrew P Weng; Fredrick G Karnell; Vytas Patriub; Lanwei Xu; Sonia Bakkour; Carlos Rodriguez; David Allman; Warren S Pear
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
Immunity 2002;16(2):231-43.
2002: Margaret A Shipp; Kenneth N Ross; Pablo Tamayo; Andrew P Weng; Jeffery L Kutok; Ricardo Aguiar; Michelle Gaasenbeek; Michael Angelo; Michael Reich; Geraldine S Pinkus; Tane S Ray; Margaret A Koval; Kim W Last; Andrew Norton; T Andrew Lister; Jill P Mesirov; Donna Neuberg; Eric S Lander; Jon C Aster; Todd R Golub
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning.
Nature medicine 2002;8(1):68-74.
2001: Christopher A French; Isao Miyoshi; Jon C Aster; Ichiro Kubonishi; Todd G Kroll; Paola Dal Cin; Sara O Vargas; Antonio R Perez-Atayde; Jonathan A Fletcher
BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19).
The American journal of pathology 2001;159(6):1987-92.
2001: Nahid G Robertson; Barbara L Resendes; J S Lin; C Lee; Jon C Aster; J C Adams; Cynthia C Morton
Inner ear localization of mRNA and protein products of COCH, mutated in the sensorineural deafness and vestibular disorder, DFNA9.
Human molecular genetics 2001;10(22):2493-500.
2001: P Andreasson; Juerg Schwaller; Ema Anastasiadou; Jon C Aster; D Gary Gilliland
The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo.
Cancer genetics and cytogenetics 2001;130(2):93-104.
2001: David Allman; Fredrick G Karnell; Jennifer A Punt; Sonia Bakkour; Lingfei Xu; Peggy S Myung; Gary A Koretzky; JC Pui; Jon C Aster; Warren S Pear
Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells.
The Journal of experimental medicine 2001;194(1):99-106.
2001: A Rangarajan; Claudio Talora; Ryuhei Okuyama; M Nicolas; Cristina Mammucari; H Oh; Jon C Aster; S Krishna; D Metzger; P Chambon; L Miele; Michel Aguet; Freddy Radtke; G Paolo Dotto
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.
The EMBO journal 2001;20(13):3427-36.
2001: Jon C Aster; Warren S Pear
Notch signaling in leukemia.
Current opinion in hematology 2001;8(4):237-44.
2000: J L Hecht; Jon C Aster
Molecular biology of Burkitt's lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(21):3707-21.
2000: Jon C Aster; Lingfei Xu; Fredrick G Karnell; Vytas Patriub; JC Pui; Warren S Pear
Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.
Molecular and cellular biology 2000;20(20):7505-15.
2000: Juerg Schwaller; Evan Parganas; Demin Wang; D Cain; Jon C Aster; Ifor Williams; C K Lee; R Gerthner; T Kitamura; J Frantsve; Ema Anastasiadou; Mignon L Loh; D E Levy; James N Ihle; D Gary Gilliland
Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.
Molecular cell 2000;6(3):693-704.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; W Taylor Kimberly; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Journal of neurochemistry 2000;75(2):583-93.
2000: Sheng Xiao; J G McCarthy; Jon C Aster; Jonathan A Fletcher
ZNF198-FGFR1 transforming activity depends on a novel proline-rich ZNF198 oligomerization domain.
Blood 2000;96(2):699-704.
2000: Q Liu; Juerg Schwaller; Jeffery L Kutok; D Cain; Jon C Aster; Ifor Williams; D Gary Gilliland
Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia.
The EMBO journal 2000;19(8):1827-38.
2000: Matthew D Rand; L M Grimm; Spyros Artavanis-Tsakonas; Vytas Patriub; Stephen C Blacklow; J Sklar; Jon C Aster
Calcium depletion dissociates and activates heterodimeric notch receptors.
Molecular and cellular biology 2000;20(5):1825-35.
2000: Michael H Tomasson; David W Sternberg; Ifor Williams; M Carroll; D Cain; Jon C Aster; RL Ilaria; Richard A Van Etten; D Gary Gilliland
Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581.
The Journal of clinical investigation 2000;105(4):423-32.
2000: Murray A Cotter; J Callahan; Jon C Aster; E Robertson
Intracellular forms of human NOTCH1 functionally activate essential Epstein-Barr virus major latent promoters in the Burkitt's lymphoma BJAB cell line but repress these promoters in Jurkat cells.
Journal of virology 2000;74(3):1486-94.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():223-6.
2000: J Callahan; Jon C Aster; Jeffrey Sklar; Elliott Kieff; Erle S Robertson
Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells.
Leukemia 2000;14(1):84-92.
1999: JC Pui; David Allman; Lingfei Xu; S DeRocco; Fredrick G Karnell; Sonia Bakkour; J Y Lee; Tom Kadesch; Richard R Hardy; Jon C Aster; Warren S Pear
Notch1 expression in early lymphopoiesis influences B versus T lineage determination.
Immunity 1999;11(3):299-308.
1999: Jon C Aster; W B Simms; Z Zavala-Ruiz; Vytas Patriub; Christopher L North; Stephen C Blacklow
The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent.
Biochemistry 1999;38(15):4736-42.
1999: Nadia Carlesso; Jon C Aster; Jeffrey Sklar; David T Scadden
Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics.
Blood 1999;93(3):838-48.
1999: Warren S Pear; Z Tang; S DeRocco; David Allman; R Hardy; JC Pui; Lingfei Xu; Fredrick G Karnell; Jon C Aster; Tom Kadesch
Consequences of Notch-mediated inhibition of the transcription factor E47.
Cold Spring Harbor symposia on quantitative biology 1999;64():33-8.
1998: Warren S Pear; Juli P Miller; Lingfei Xu; JC Pui; B Soffer; RC Quackenbush; Ann Marie Pendergast; R Bronson; Jon C Aster; M L Scott; David Baltimore
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow.
Blood 1998;92(10):3780-92.
1998: Juerg Schwaller; J Frantsve; Jon C Aster; Ifor Williams; Michael H Tomasson; Theodora S Ross; Pieter Peeters; L Van Rompaey; Richard A Van Etten; RL Ilaria; Peter Marynen; D Gary Gilliland
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.
The EMBO journal 1998;17(18):5321-33.
1998: Arnold S Freedman; Donna Neuberg; John G Gribben; Peter M Mauch; Robert J Soiffer; David C Fisher; Kenneth C Anderson; N Andersen; Robert Schlossman; M Kroon; Jerome Ritz; Jon C Aster; Lee M Nadler
High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(1):13-8.
1998: Sheng Xiao; S R Nalabolu; Jon C Aster; J Ma; L Abruzzo; E S Jaffe; R Stone; S M Weissman; T J Hudson; Jonathan A Fletcher
FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome.
Nature genetics 1998;18(1):84-7.
1997: Niels S Andersen; John W Donovan; J S Borus; Christine M Poor; Donna Neuberg; Jon C Aster; Lee M Nadler; Arnold S Freedman; John G Gribben
Failure of immunologic purging in mantle cell lymphoma assessed by polymerase chain reaction detection of minimal residual disease.
Blood 1997;90(10):4212-21.
1997: B Luo; Jon C Aster; Robert P Hasserjian; Frank C Kuo; Jeffrey Sklar
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor.
Molecular and cellular biology 1997;17(10):6057-67.
1997: Jon C Aster; Erle S Robertson; Robert P Hasserjian; Jerrold R Turner; Elliott Kieff; Jeffrey Sklar
Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
The Journal of biological chemistry 1997;272(17):11336-43.
1996: Robert P Hasserjian; Jon C Aster; F Davi; D S Weinberg; Jeffrey Sklar
Modulated expression of notch1 during thymocyte development.
Blood 1996;88(3):970-6.
1996: C Y Ho; Britt Otterud; Robert D Legare; T Varvil; R Saxena; D B DeHart; S E Kohler; Jon C Aster; S B Dowton; Frederick P Li; M Leppert; D Gary Gilliland
Linkage of a familial platelet disorder with a propensity to develop myeloid malignancies to human chromosome 21q22.1-22.2.
Blood 1996;87(12):5218-24.
1996: Warren S Pear; Jon C Aster; Martin L Scott; Robert P Hasserjian; B Soffer; Jeffrey Sklar; David Baltimore
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.
The Journal of experimental medicine 1996;183(5):2283-91.
1995: R C Inhorn; Jon C Aster; S A Roach; C A Slapak; Robert J Soiffer; R Tantravahi; Richard M Stone
A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity.
Blood 1995;85(7):1881-7.
1994: Richard M Stone; Donna Neuberg; Robert J Soiffer; Tak Takvorian; M Whelan; S N Rabinowe; Jon C Aster; P Leavitt; Peter M Mauch; Arnold S Freedman
Myelodysplastic syndrome as a late complication following autologous bone marrow transplantation for non-Hodgkin's lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(12):2535-42.
1994: Richard M Stone; Steven H Bernstein; George D Demetri; D P Facklam; K Arthur; J Andersen; Jon C Aster; Donald Kufe
Therapy with recombinant human erythropoietin in patients with myelodysplastic syndromes.
Leukemia research 1994;18(10):769-76.
1994: J M Munro; Arnold S Freedman; Jon C Aster; John G Gribben; N C Lee; K K Rhynhart; Jacques Banchereau; Lee M Nadler
In vivo expression of the B7 costimulatory molecule by subsets of antigen-presenting cells and the malignant cells of Hodgkin's disease.
Blood 1994;83(3):793-8.
1994: Jon C Aster; Warren S Pear; Robert P Hasserjian; Harry P Erba; F Davi; B Luo; M Scott; David Baltimore; Jeffrey Sklar
Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch.
Cold Spring Harbor symposia on quantitative biology 1994;59():125-36.
1993: Anindya Dutta; J M Ruppert; Jon C Aster; E Winchester
Inhibition of DNA replication factor RPA by p53.
Nature 1993;365(6441):79-82.
1992: Jon C Aster; Jeffrey Sklar
Interallelic V(D)J trans-rearrangement within the beta T cell receptor gene is infrequent and occurs preferentially during attempted D beta to J beta joining.
The Journal of experimental medicine 1992;175(6):1773-82.
1990: R L Deresiewicz; Richard M Stone; Jon C Aster
Fatal disseminated mycobacterial infection following intravesical bacillus Calmette-Guerin.
The Journal of urology 1990;144(6):1331-3; discussion 1333-4.
1989: Jonathan A Fletcher; Jon C Aster; C C Morton
Association of trisomy 8 and squamous differentiation in an endometrial adenocarcinoma.
Cancer genetics and cytogenetics 1989;39(2):185-9.