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Masao Hirose

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
91
Nishikawa, Akiyoshi
75
Shirai, Tomoyuki
75
Ito, Nobuyuki
43
Shibutani, Makoto
41
Mitsumori, Kunitoshi
39
Furukawa, Fumio
37
Imazawa, Takayoshi
36
Umemura, Takashi
34
Takahashi, Satoru
33
Imai, Toshio
26
Uneyama, Chikako
25
Onodera, Hiroshi
25
Kanki, Keita
23
Kitamura, Yasuki
23
Futakuchi, Mitsuru

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Publications

TOP 3
Shibutani Makoto; Woo Gye-Hyeong; Fujimoto Hitoshi; Saegusa Yukie; Takahashi Miwa; Inoue Kaoru; Hirose Masao; Nishikawa Akiyoshi
Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents.
Imai Toshio; Hasumura Mai; Cho Young-Man; Ota Yoshio; Takami Shigeaki; Hirose Masao; Nishikawa Akiyoshi
Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.
Cho Y-M; Imai T; Ito Y; Takami S; Hasumura M; Yamazaki T; Hirose M; Nishikawa A
A 13-week subchronic toxicity study of dietary administered saponin-rich and isoflavones-containing soybean extract in F344 rats.

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All Publications

2009: Shibutani Makoto; Woo Gye-Hyeong; Fujimoto Hitoshi; Saegusa Yukie; Takahashi Miwa; Inoue Kaoru; Hirose Masao; Nishikawa Akiyoshi
Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents.
Reproductive toxicology (Elmsford, N.Y.) 2009;28(3):297-307.
2009: Imai Toshio; Hasumura Mai; Cho Young-Man; Ota Yoshio; Takami Shigeaki; Hirose Masao; Nishikawa Akiyoshi
Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.
Cancer science 2009;100(10):1794-800.
2009: Cho Y-M; Imai T; Ito Y; Takami S; Hasumura M; Yamazaki T; Hirose M; Nishikawa A
A 13-week subchronic toxicity study of dietary administered saponin-rich and isoflavones-containing soybean extract in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(8):2150-6.
2009: Ota Yoshio; Imai Toshio; Onose Jun-Ichi; Takami Shigeaki; Cho Young-Man; Hirose Masao; Nishikawa Akiyoshi
A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats.
The Journal of toxicological sciences 2009;34(3):305-13.
2009: Inoue Kaoru; Yoshida Midori; Takahashi Miwa; Fujimoto Hitoshi; Ohnishi Kuniyoshi; Nakashima Koichi; Shibutani Makoto; Hirose Masao; Nishikawa Akiyoshi
Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(4):752-9.
2009: Imai Toshio; Takami Shigeaki; Cho Young-Man; Hirose Masao; Nishikawa Akiyoshi
Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.
Toxicology letters 2009;185(3):160-7.
2009: Inoue Kaoru; Yoshida Midori; Takahashi Miwa; Shibutani Makoto; Takagi Hironori; Hirose Masao; Nishikawa Akiyoshi
Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(1):184-91.
2008: Inoue Kaoru; Shibutani Makoto; Masutomi Naoya; Toyoda Kazuhiro; Takagi Hironori; Takahashi Miwa; Fujimoto Hitoshi; Hirose Masao; Nishikawa Akiyoshi
One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(10):3303-10.
2008: Sugita-Konishi Y; Kubosaki A; Takahashi M; Park B J; Tanaka T; Takatori K; Hirose M; Shibutani M
Nivalenol and the targeting of the female reproductive system as well as haematopoietic and immune systems in rats after 90-day exposure through the diet.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2008;25(9):1118-27.
2008: Umemura Takashi; Maeda Machiko; Kijima Aki; Ishii Yuji; Tasaki Masako; Okamura Toshiya; Inoue Tomoki; Hirose Masao; Nishikawa Akiyoshi
Lack of promotion activity of diacylglycerol oil on 4-nitroquinoline 1-oxide induced carcinogenesis in the oral cavity of SD rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(9):3206-12.
2008: Tasaki Masako; Umemura Takashi; Inoue Tomoki; Okamura Toshiya; Kuroiwa Yuichi; Ishii Yuji; Maeda Machiko; Hirose Masao; Nishikawa Akiyoshi
Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 year.
Toxicology 2008;250(2-3):143-50.
2008: Kawabe Mayumi; Futakuchi Mitsuru; Tamano Seiko; Shirai Tomoyuki; Hirose Masao
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesis model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(8):2758-63.
2008: Kuroiwa Yuichi; Yamada Masami; Matsui Keiko; Okamura Toshiya; Ishii Yuji; Masumura Ken-ichi; Tasaki Masako; Umemura Takashi; Mitsumori Kunitoshi; Nohmi Takehiko; Hirose Masao; Nishikawa Akiyoshi
Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):274-82.
2008: Takami S; Imai T; Hasumura M; Cho Y-M; Onose J; Hirose M
Evaluation of toxicity of green tea catechins with 90-day dietary administration to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(6):2224-9.
2008: Onose Jun-Ichi; Imai Toshio; Hasumura Mai; Ueda Makoto; Ozeki Yoshihiro; Hirose Masao
Evaluation of subchronic toxicity of dietary administered Cry1Ab protein from Bacillus thuringiensis var. Kurustaki HD-1 in F344 male rats with chemically induced gastrointestinal impairment.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(6):2184-9.
2008: Tasaki M; Umemura T; Maeda M; Ishii Y; Okamura T; Inoue T; Kuroiwa Y; Hirose M; Nishikawa A
Safety assessment of ellagic acid, a food additive, in a subchronic toxicity study using F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(3):1119-24.
2008: Takahashi Miwa; Shibutani Makoto; Inoue Kaoru; Fujimoto Hitoshi; Hirose Masao; Nishikawa Akiyoshi
Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study.
The Journal of toxicological sciences 2008;33(1):11-24.
2008: Kuroiwa Yuichi; Okamura Toshiya; Ishii Yuji; Umemura Takashi; Tasaki Masako; Kanki Keita; Mitsumori Kunitoshi; Hirose Masao; Nishikawa Akiyoshi
Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation.
Cancer science 2008;99(1):7-13.
2008: Inoue Kaoru; Shibutani Makoto; Masutomi Naoya; Toyoda Kazuhiro; Takagi Hironori; Uneyama Chikako; Nishikawa Akiyoshi; Hirose Masao
A 13-week subchronic toxicity study of madder color in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(1):241-52.
2008: Takahashi Miwa; Shibutani Makoto; Sugita-Konishi Yoshiko; Aihara Maki; Inoue Kaoru; Woo Gye-Hyeong; Fujimoto Hitoshi; Hirose Masao
A 90-day subchronic toxicity study of nivalenol, a trichothecene mycotoxin, in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(1):125-35.
2008: Kanki Keita; Umemura Takashi; Kitamura Yasuki; Ishii Yuji; Kuroiwa Yuichi; Kodama Yukio; Itoh Ken; Yamamoto Masayuki; Nishikawa Akiyoshi; Hirose Masao
A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate.
Toxicologic pathology 2008;36(2):353-61.
2008: Cho Young-Man; Imai Toshio; Ota Yoshio; Hasumura Mai; Takami Shigeaki; Hirose Masao; Nishikawa Akiyoshi
A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers.
Toxicologic pathology 2008;36(3):459-64.
2007: Imai Toshio; Fukuta Katsuhiro; Hasumura Mai; Cho Young-Man; Ota Yoshio; Takami Shigeaki; Nakagama Hitoshi; Hirose Masao
Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Carcinogenesis 2007;28(10):2199-206.
2007: Umemura Takashi; Kuroiwa Yuichi; Tasaki Masako; Okamura Toshiya; Ishii Yuji; Kodama Yukio; Nohmi Takehiko; Mitsumori Kunitoshi; Nishikawa Akiyoshi; Hirose Masao
Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice.
Mutation research 2007;633(1):46-54.
2007: Woo Gye-Hyeong; Shibutani Makoto; Kuroiwa Keiko; Lee Kyoung-Youl; Takahashi Miwa; Inoue Kaoru; Fujimoto Hitoshi; Hirose Masao
Lack of preventive effects of dietary fibers or chlorophyllin against acrylamide toxicity in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(8):1507-15.
2007: Kuroiwa Yuichi; Ishii Yuji; Umemura Takashi; Kanki Keita; Mitsumori Kunitoshi; Nishikawa Akiyoshi; Nakazawa Hiroyuki; Hirose Masao
Combined treatment with green tea catechins and sodium nitrite selectively promotes rat forestomach carcinogenesis after initiation with N-methyl-N'- nitro-N-nitrosoguanidine.
Cancer science 2007;98(7):949-57.
2007: Woo Gye-Hyeong; Shibutani Makoto; Inoue Kaoru; Fujimoto Hitoshi; Takahashi Miwa; Lee Kyoung-Youl; Hirose Masao
Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(7):1160-4.
2007: Imai Toshio; Hasumura Mai; Cho Young-Man; Onose Jun-Ichi; Hirose Masao
Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats.
Cancer science 2007;98(3):294-8.
2007: Shibutani Makoto; Lee Kyoung-Youl; Igarashi Katsuhide; Woo Gye-Hyeong; Inoue Kaoru; Nishimura Tetsuji; Hirose Masao
Hypothalamus region-specific global gene expression profiling in early stages of central endocrine disruption in rat neonates injected with estradiol benzoate or flutamide.
Developmental neurobiology 2007;67(3):253-69.
2007: Woo Gye-Hyeong; Shibutani Makoto; Ichiki Tsutomu; Hamamura Masao; Lee Kyoung-Youl; Inoue Kaoru; Hirose Masao
A repeated 28-day oral dose toxicity study of nonylphenol in rats, based on the 'Enhanced OECD Test Guideline 407' for screening of endocrine-disrupting chemicals.
Archives of toxicology 2007;81(2):77-88.
2007: Kitamura Yasuki; Umemura Takashi; Kanki Keita; Kodama Yukio; Kitamoto Sachiko; Saito Koichi; Itoh Ken; Yamamoto Masayuki; Masegi Toshiaki; Nishikawa Akiyoshi; Hirose Masao
Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline.
Cancer science 2007;98(1):19-24.
2007: Kuroiwa Yuichi; Umemura Takashi; Nishikawa Akiyoshi; Kanki Keita; Ishii Yuji; Kodama Yukio; Masumura Ken-ichi; Nohmi Takehiko; Hirose Masao
Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice.
Archives of toxicology 2007;81(1):63-9.
2007: Hasumura Mai; Ueda Makoto; Onose Jun-ichi; Imai Toshio; Hirose Masao
Lack of a significant effect of arctiin on development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats.
Nutrition and cancer 2007;57(2):201-8.
2006: Cho Young-Man; Imai Toshio; Hasumura Mai; Hirose Masao
Lack of enhancement of susceptibility to mammary and thyroid carcinogenesis in rats exposed to DMBA and DHPN following prepubertal iodine deficiency.
Cancer science 2006;97(10):1031-6.
2006: Umemura Takashi; Kanki Keita; Kuroiwa Yuichi; Ishii Yuji; Okano Keita; Nohmi Takehiko; Nishikawa Akiyoshi; Hirose Masao
In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate.
Cancer science 2006;97(9):829-35.
2006: Kuroiwa Yuichi; Nishikawa Akiyoshi; Kitamura Yasuki; Kanki Keita; Ishii Yuji; Umemura Takashi; Hirose Masao
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
Cancer letters 2006;241(2):275-80.
2006: Kuroiwa Keiko; Shibutani Makoto; Inoue Kaoru; Lee Kyoung-Youl; Woo Gye-Hyeong; Hirose Masao
Subchronic toxicity study of water pepper extract in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(8):1236-44.
2006: Cho Y-M; Onodera H; Ueda M; Imai T; Hirose M
A 13-week subchronic toxicity study of dietary administered morin in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(6):891-7.
2006: Imai Toshio; Onose Jun-ichi; Hasumura Mai; Takizawa Tamotsu; Hirose Masao
Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicology letters 2006;164(1):71-80.
2006: Kitamura Yasuki; Umemura Takashi; Kanki Keita; Ishii Yuji; Kuroiwa Yuichi; Masegi Toshiaki; Nishikawa Akiyoshi; Hirose Masao
Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis: results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer science 2006;97(5):368-73.
2006: Tamura Toru; Mitsumori Kunitoshi; Totsuka Yukari; Wakabayashi Keiji; Kido Rie; Kasai Hiroshi; Nasu Masahiro; Hirose Masao
Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid.
Toxicology 2006;222(3):213-24.
2006: Kitamura Yasuki; Umemura Takashi; Okazaki Kazushi; Kanki Keita; Imazawa Takayoshi; Masegi Toshiaki; Nishikawa Akiyoshi; Hirose Masao
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
International journal of cancer. Journal international du cancer 2006;118(10):2399-404.
2006: Lee Kyoung-Youl; Shibutani Makoto; Inoue Kaoru; Kuroiwa Keiko; U Mami; Woo Gye-Hyeong; Hirose Masao
Methacarn fixation--effects of tissue processing and storage conditions on detection of mRNAs and proteins in paraffin-embedded tissues.
Analytical biochemistry 2006;351(1):36-43.
2006: Kitamura Yasuki; Yamagishi Megumi; Okazaki Kazushi; Furukawa Fumio; Imazawa Takayoshi; Nishikawa Akiyoshi; Hirose Masao
Lack of enhancing effects of sodium nitrite on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Cancer letters 2006;235(1):69-74.
2006: Okazaki Kazushi; Ishii Yuji; Kitamura Yasuki; Maruyama Satoshi; Umemura Takashi; Miyauchi Makoto; Yamagishi Megumi; Imazawa Takayoshi; Nishikawa Akiyoshi; Yoshimura Yoshihiro; Nakazawa Hiroyuki; Hirose Masao
Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage.
Cancer science 2006;97(3):175-82.
2006: Umemura Takashi; Kuroiwa Yuichi; Kitamura Yasuki; Ishii Yuji; Kanki Keita; Kodama Yukio; Itoh Ken; Yamamoto Masayuki; Nishikawa Akiyoshi; Hirose Masao
A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(1):111-9.
2006: Kitamura Y; Yamagishi M; Okazaki K; Umemura T; Imazawa T; Nishikawa A; Matsumoto W; Hirose M
Lack of chemopreventive effects of alpha-eleostearic acid on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(2):271-7.
2006: Onose Jun-ichi; Imai Toshio; Hasumura Mai; Cho Young-Man; Hirose Masao
A new medium-term rat colon bioassay applying neoplastic lesions as endpoints for detection of carcinogenesis modifiers-validation with known modifiers.
Cancer letters 2006;232(2):272-8.
2006: Umemura Takashi; Kodama Yukio; Nishikawa Akiyoshi; Hioki Kyoji; Nomura Tatsuji; Kanki Keita; Kuroiwa Yuichi; Ishii Yuji; Kurokawa Yuji; Hirose Masao
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Cancer letters 2006;231(2):314-8.
2006: Takizawa Tamotsu; Imai Toshio; Ueda Makoto; Onodera Hiroshi; Hirose Masao
Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds.
Cancer science 2006;97(1):25-31.
2006: Nishikawa Akiyoshi; Sai Kimie; Okazaki Kazushi; Son Hwa-Young; Kanki Keita; Nakajima Madoka; Kinae Naohide; Nohmi Takehiko; Trosko James E; Inoue Tohru; Hirose Masao
MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells.
Environmental and molecular mutagenesis 2006;47(1):48-55.
2006: Kuroiwa Y; Nishikawa A; Imazawa T; Kitamura Y; Kanki K; Ishii Y; Umemura T; Hirose M
A subchronic toxicity study of dunaliella carotene in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(1):138-45.
2006: Ota Y; Hasumura M; Okamura M; Takahashi A; Ueda M; Onodera H; Imai T; Mitsumori K; Hirose M
Chronic toxicity and carcinogenicity of dietary administered ammonium sulfate in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(1):17-27.
2006: Fujimoto Hitoshi; Shibutani Makoto; Kuroiwa Keiko; Inoue Kaoru; Woo Gye-Hyeong; U Mami; Hirose Masao
A case report of a spontaneous gastrointestinal stromal tumor (GIST) occurring in a F344 rat.
Toxicologic pathology 2006;34(2):164-7.
2005: Imai Toshio; Cho Young-Man; Hasumura Mai; Hirose Masao
Enhancement by acrylamide of N-methyl-N-nitrosourea-induced rat mammary tumor development-possible application for a model to detect co-modifiers of carcinogenesis.
Cancer letters 2005;230(1):25-32.
2005: Takagi Hironori; Shibutani Makoto; Lee Kyoung-Youl; Masutomi Naoya; Fujita Haruka; Inoue Kaoru; Mitsumori Kunitoshi; Hirose Masao
Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring.
Toxicology and applied pharmacology 2005;208(2):127-36.
2005: Kuroiwa Y; Nishikawa A; Imazawa T; Kitamura Y; Kanki K; Umemura T; Hirose M
Lack of carcinogenicity of D-xylose given in the diet to F344 rats for two years.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(9):1399-404.
2005: Lee Kyoung-Youl; Shibutani Makoto; Kuroiwa Keiko; Takagi Hironori; Inoue Kaoru; Nishikawa Hiroshi; Miki Tokutaro; Hirose Masao
Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanate.
Archives of toxicology 2005;79(9):531-41.
2005: Nishikawa Akiyoshi; Ikeda Takako; Son Hwa-Young; Okazaki Kazushi; Imazawa Takayoshi; Umemura Takashi; Kimura Shuichi; Hirose Masao
Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):258-63.
2005: Hasumura M; Imai T; Takizawa T; Ueda M; Onose J; Hirose M
Promotion of thyroid carcinogenesis by para-aminobenzoic acid in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(1):61-7.
2005: Kuroiwa Y; Nishikawa A; Imazawa T; Kanki K; Kitamura Y; Umemura T; Hirose M
Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(7):1047-53.
2005: Cho Young-Man; Imai Toshio; Hasumura Mai; Onose Jun-Ichi; Ueda Makoto; Hirose Masao
Lack of prepubertal administration of ethinyl estradiol on susceptibility to multiple organ carcinogenesis in rats exposed to 7,12-dimethylbenz[a]anthracene and N-bis(2-hydroxypropyl)nitrosamine during adolescence.
Cancer letters 2005;223(1):37-46.
2005: Nishikawa Akiyoshi; Imazawa Takayoshi; Kuroiwa Yuichi; Kitamura Yasuki; Kanki Keita; Ishii Yuji; Umemura Takashi; Hirose Masao
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
Toxicological sciences : an official journal of the Society of Toxicology 2005;84(2):243-8.
2005: Takagi Hironori; Shibutani Makoto; Uneyama Chikako; Lee Kyoung-Youl; Kato Natsumi; Inoue Kaoru; Hirose Masao
Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model.
Cancer letters 2005;219(2):147-53.
2005: Shibutani Makoto; Masutomi Naoya; Uneyama Chikako; Abe Naoko; Takagi Hironori; Lee Kyoung-Youl; Hirose Masao
Down-regulation of GAT-1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol.
Toxicology 2005;208(1):35-48.
2005: Ichihara Toshio; Miyashita Kayoko; Kawabe Mayumi; Imaida Katsumi; Asamoto Makoto; Ogiso Tadashi; Tamano Seiko; Hirose Masao; Shirai Tomoyuki
Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.
The Journal of toxicological sciences 2005;30(1):1-6.
2005: Imai Toshio; Hasumura Mai; Onose Jun-ichi; Ueda Makoto; Takizawa Tamotsu; Cho Young-Man; Hirose Masao
Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model: biological impact of capsular inflammation and reduced cyclooxygenase-2 expression.
Cancer science 2005;96(1):31-7.
2005: Ueda Makoto; Imai Toshio; Takizawa Tamotsu; Onodera Hiroshi; Mitsumori Kunitoshi; Matsui Takane; Hirose Masao
Possible enhancing effects of atrazine on growth of 7,12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats.
Cancer science 2005;96(1):19-25.
2005: Kanki Keita; Nishikawa Akiyoshi; Masumura Ken-Ichi; Umemura Takashi; Imazawa Takayoshi; Kitamura Yasuki; Nohmi Takehiko; Hirose Masao
In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate.
Molecular carcinogenesis 2005;42(1):9-17.
2005: Kitamura Yasuki; Nishikawa Akiyoshi; Nakamura Hideaki; Furukawa Fumio; Imazawa Takayoshi; Umemura Takashi; Uchida Koji; Hirose Masao
Effects of N-acetylcysteine, quercetin, and phytic acid on spontaneous hepatic and renal lesions in LEC rats.
Toxicologic pathology 2005;33(5):584-92.
2004: Nishikawa Akiyoshi; Mori Yukio; Lee In-Seon; Tanaka Takuji; Hirose Masao
Cigarette smoking, metabolic activation and carcinogenesis.
Current drug metabolism 2004;5(5):363-73.
2004: Lee Kyoung-Youl; Shibutani Makoto; Takagi Hironori; Kato Natsumi; Takigami Shu; Uneyama Chikako; Hirose Masao
Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation.
Toxicology 2004;203(1-3):221-38.
2004: Takizawa Tamotsu; Imai Toshio; Onose Jun-ichi; Ueda Makoto; Tamura Toru; Mitsumori Kunitoshi; Izumi Keisuke; Hirose Masao
Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(1):43-9.
2004: Kato Natsumi; Shibutani Makoto; Takagi Hironori; Uneyama Chikako; Lee Kyoung-Youl; Takigami Shu; Mashima Keisuke; Hirose Masao
Gene expression profile in the livers of rats orally administered ethinylestradiol for 28 days using a microarray technique.
Toxicology 2004;200(2-3):179-92.
2004: Takagi Hironori; Shibutani Makoto; Lee Kyoung-Youl; Lee Hwi Cheul; Nishihara Masugi; Uneyama Chikako; Takigami Shu; Mitsumori Kunitoshi; Hirose Masao
Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats.
Reproductive toxicology (Elmsford, N.Y.) 2004;18(5):687-700.
2004: Takagi Hironori; Shibutani Makoto; Kato Natsumi; Fujita Haruka; Lee Kyoung-Youl; Takigami Shu; Mitsumori Kunitoshi; Hirose Masao
Microdissected region-specific gene expression analysis with methacarn-fixed, paraffin-embedded tissues by real-time RT-PCR.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(7):903-13.
2004: Nishikawa Akiyoshi; Furukawa Fumio; Lee In-Seon; Tanaka Takuji; Hirose Masao
Potent chemopreventive agents against pancreatic cancer.
Current cancer drug targets 2004;4(4):373-84.
2004: Son Hwa-Young; Nishikawa Akiyoshi; Okazaki Kazushi; Kitamura Yasuki; Kanki Keita; Lee Kyong-Youl; Umemura Takashi; Hirose Masao
Specificity of co-promoting effects of caffeine on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicologic pathology 2004;32(3):338-44.
2004: Umemura Takashi; Kitamura Yasuki; Kanki Keita; Maruyama Satoshi; Okazaki Kazushi; Imazawa Takayoshi; Nishimura Tetsuji; Hasegawa Ryuichi; Nishikawa Akiyoshi; Hirose Masao
Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate.
Cancer science 2004;95(5):393-8.
2004: Lee Kyoung-Youl; Shibutani Makoto; Takagi Hironori; Arimura Takuro; Takigami Shu; Uneyama Chikako; Kato Natsumi; Hirose Masao
Subchronic toxicity study of dietary N-acetylglucosamine in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(4):687-95.
2004: Masutomi Naoya; Shibutani Makoto; Takagi Hironori; Uneyama Chikako; Lee Kyoung-Youl; Hirose Masao
Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals.
Archives of toxicology 2004;78(4):232-40.
2004: Orita Shinichiro; Hirose Masao; Takahashi Satoru; Imaida Katsumi; Ito Nobuyuki; Shudo Koichi; Ohigashi Hajime; Murakami Akira; Shirai Tomoyuki
Modifying effects of 1'-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats.
Toxicologic pathology 2004;32(2):250-7.
2004: Imai Toshio; Onose Jun-ichi; Hasumura Mai; Ueda Makoto; Takizawa Tamotsu; Hirose Masao
Sequential analysis of development of invasive thyroid follicular cell carcinomas in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.
Toxicologic pathology 2004;32(2):229-36.
2004: Hasumura M; Yasuhara K; Tamura T; Imai T; Mitsumori K; Hirose M
Evaluation of the toxicity of enzymatically decomposed rutin with 13-weeks dietary administration to Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(3):439-44.
2004: Takagi Hironori; Shibutani Makoto; Masutomi Naoya; Uneyama Chikako; Takahashi Noriyuki; Mitsumori Kunitoshi; Hirose Masao
Lack of maternal dietary exposure effects of bisphenol A and nonylphenol during the critical period for brain sexual differentiation on the reproductive/endocrine systems in later life.
Archives of toxicology 2004;78(2):97-105.
2004: Masutomi Naoya; Shibutani Makoto; Takagi Hironori; Uneyama Chikako; Hirose Masao
Dietary influence on the impact of ethinylestradiol-induced alterations in the endocrine/reproductive system with perinatal maternal exposure.
Reproductive toxicology (Elmsford, N.Y.) 2004;18(1):23-33.
2004: Takizawa T; Mitsumori K; Takagi H; Nasu M; Yasuhara K; Onodera H; Imai T; Hirose M
Sequential analysis of testicular lesions and serum hormone levels in rats treated with a Psoralea corylifolia extract.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(1):1-7.
2003: Son Hwa-Young; Nishikawa Akiyoshi; Okazaki Kazushi; Lee Kyong- Youl; Imazawa Takayoshi; Hirose Masao
Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(12):1811-6.
2003: Okazaki Kazushi; Umemura Takashi; Imazawa Takayoshi; Nishikawa Akiyoshi; Masegi Toshiaki; Hirose Masao
Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation.
Cancer science 2003;94(11):948-52.
2003: Imazawa Takayoshi; Nishikawa Akiyoshi; Toyoda Kazuhiro; Furukawa Fumio; Mitsui Masayuki; Hirose Masao
Sequential alteration of apoptosis, p53 expression, and cell proliferation in the rat pancreas treated with 4-hydroxyaminoquinoline 1-oxide.
Toxicologic pathology 2003;31(6):625-31.
2003: Masutomi Naoya; Shibutani Makoto; Takagi Hironori; Uneyama Chikako; Takahashi Noriyuki; Hirose Masao
Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life.
Toxicology 2003;192(2-3):149-70.
2003: Kitamura Y; Nishikawa A; Furukawa F; Nakamura H; Okazaki K; Umemura T; Imazawa T; Hirose M
A subchronic toxicity study of shea nut color in Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(11):1537-42.
2003: Kitamura Yasuki; Yamagishi Megumi; Okazaki Kazushi; Son Hwa-Young; Imazawa Takayoshi; Nishikawa Akiyoshi; Iwata Toshio; Yamauchi Yoshie; Kasai Masaaki; Tsutsumi Kentaro; Hirose Masao
Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Cancer letters 2003;200(2):133-9.
2003: Kanki Keita; Nishikawa Akiyoshi; Furukawa Fumio; Kitamura Yasuki; Imazawa Takayoshi; Umemura Takashi; Hirose Masao
A 13-week subchronic toxicity study of paprika color in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(10):1337-43.
2003: Toyosawa Kaoru; Tanaka Kohji; Imai Toshio; Yasuhara Kazuo; Koujitani Takatoshi; Hirose Masao; Mitsumori Kunitoshi
Mutation and overexpression of the transgene in ethylnitrosourea-induced tumors in mice carrying a human prototype c-Ha-ras gene.
Toxicologic pathology 2003;31(5):491-5.
2003: Onose Jun-ichi; Imai Toshio; Hasumura Mai; Ueda Makoto; Hirose Masao
Rapid induction of colorectal tumors in rats initiated with 1,2-dimethylhydrazine followed by dextran sodium sulfate treatment.
Cancer letters 2003;198(2):145-52.
2003: Cheng Jing Lei; Futakuchi Mitsuru; Ogawa Kumiko; Iwata Toshio; Kasai Masaaki; Tokudome Shinkan; Hirose Masao; Shirai Tomoyuki
Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats.
Cancer letters 2003;196(2):161-8.
2003: Akagi Keisuke; Sano Masashi; Ogawa Kumiko; Hirose Masao; Goshima Hideo; Shirai Tomoyuki
Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats.
Toxicologic pathology 2003;31(4):388-96.
2003: Umemura Takashi; Kai Sachie; Hasegawa Ryuichi; Kanki Keita; Kitamura Yasuki; Nishikawa Akiyoshi; Hirose Masao
Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamine-induced hepato- and cholangiocarcinogenesis in mice by green tea infusion.
Carcinogenesis 2003;24(6):1105-9.
2003: Takizawa Tamotsu; Mitsumori Kunitoshi; Tamura Toru; Nasu Masahiro; Ueda Makoto; Imai Toshio; Hirose Masao
Hepatocellular tumor induction in heterozygous p53-deficient CBA mice by a 26-week dietary administration of kojic acid.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):287-93.
2003: Son Hwa-Young; Nishikawa Akiyoshi; Kanki Keita; Okazaki Kazushi; Kitamura Yasuki; Lee Kyong-Youl; Umemura Takashi; Hirose Masao
Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer science 2003;94(4):334-7.
2003: Furukawa Fumio; Nishikawa Akiyoshi; Lee In-Seon; Kanki Keita; Umemura Takashi; Okazaki Kazushi; Kawamori Toshihito; Wakabayashi Keiji; Hirose Masao
A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
International journal of cancer. Journal international du cancer 2003;104(3):269-73.
2003: Sugiura Satoshi; Ogawa Kumiko; Hirose Masao; Takeshita Fumitaka; Asamoto Makoto; Shirai Tomoyuki
Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.
Carcinogenesis 2003;24(3):547-53.
2003: Yamagishi Megumi; Natsume Midori; Osakabe Naomi; Okazaki Kazushi; Furukawa Fumio; Imazawa Takayoshi; Nishikawa Akiyoshi; Hirose Masao
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Cancer letters 2003;191(1):49-57.
2003: Son Hwa-Young; Nishikawa Akiyoshi; Okazaki Kazushi; Kanki Keita; Yamagishi Megumi; Imazawa Takayoshi; Umemura Takashi; Hirose Masao
Prolonged effects of beta-estradiol 3-benzoate on thyroid tumorigenesis in gonadectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer letters 2003;190(1):21-9.
2003: Umemura Takashi; Kodama Yukio; Kanki Keita; Iatropoulos Michael J; Nishikawa Akiyoshi; Hirose Masao; Williams Gary M
Pentachlorophenol (but not phenobarbital) promotes intrahepatic biliary cysts induced by diethylnitrosamine to cholangio cystic neoplasms in B6C3F1 mice possibly due to oxidative stress.
Toxicologic pathology 2003;31(1):10-3.
2003: Ueda Makoto; Niho Naoko; Imai Toshio; Shibutani Makoto; Mitsumori Kunitoshi; Matsui Takane; Hirose Masao
Lack of significant effects of genistein on the progression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats.
Nutrition and cancer 2003;47(2):141-7.
2002: Yada Hideaki; Hirose Masao; Tamano Seiko; Kawabe Mayumi; Sano Masashi; Takahashi Satoru; Futakuchi Mitsuru; Miki Tokutaro; Shirai Tomoyuki
Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model.
Japanese journal of cancer research : Gann 2002;93(12):1299-307.
2002: Hirose Masao; Yamaguchi Tsuyoshi; Mizoguchi Yasumoto; Akagi Keisuke; Futakuchi Mitsuru; Shirai Tomoyuki
Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses.
Cancer letters 2002;188(1-2):163-70.
2002: Yamagishi Megumi; Natsume Midori; Osakabe Naomi; Nakamura Hideaki; Furukawa Fumio; Imazawa Takayoshi; Nishikawa Akiyoshi; Hirose Masao
Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats.
Cancer letters 2002;185(2):123-30.
2002: Suzuki Shugo; Takahashi Satoru; Asamoto Makoto; Inaguma Shingo; Ogiso Tadashi; Hirose Masao; Shirai Tomoyuki
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer.
Cancer letters 2002;185(1):39-45.
2002: Imai T; Yasuhara K; Matsui H; Maruyama S; Fujimoto N; Mitsumori K; Hirose M
Iron lactate induction of pancreatic and endometrial proliferative lesions and a lack of increased tumors in a 104-week carcinogenicity study in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(10):1441-8.
2002: Okazaki Kazushi; Okazaki Shuzo; Nakamura Hideaki; Kitamura Yasuki; Hatayama Kazuhisa; Wakabayashi Sachiko; Tsuda Toshiharu; Katsumata Tomoyoshi; Nishikawa Akiyoshi; Hirose Masao
A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals.
Archives of toxicology 2002;76(10):553-9.
2002: Uneyama Chikako; Shibutani Makoto; Masutomi Naoya; Takagi Hironori; Hirose Masao
Methacarn fixation for genomic DNA analysis in microdissected, paraffin-embedded tissue specimens.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(9):1237-45.
2002: Umemura Takashi; Kodama Yukio; Hioki Kyoji; Nomura Tatsuji; Nishikawa Akiyoshi; Hirose Masao; Kurokawa Yuji
The mouse rasH2/BHT model as an in vivo rapid assay for lung carcinogens.
Japanese journal of cancer research : Gann 2002;93(8):861-6.
2002: Ueda Makoto; Takagi Hisayoshi; Onodera Hiroshi; Yasuhara Kazuo; Takizawa Tamotsu; Imai Toshio; Mitsumori Kunitoshi; Matsui Takane; Hirose Masao
Enhancing effects of beta-estradiol 3-benzoate but not methoxychlor on the promotion/progression stage of chemically-induced mammary carcinogenesis in ovariectomized rats.
Japanese journal of cancer research : Gann 2002;93(7):752-9.
2002: Kasahara K; Nishikawa A; Furukawa F; Ikezaki S; Tanakamaru Z; Lee I-S; Imazawa T; Hirose M
A chronic toxicity study of josamycin in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(7):1017-22.
2002: Furukawa F; Nishikawa A; Kitahori Y; Tanakamaru Z; Hirose M
Spontaneous development of aberrant crypt foci in F344 rats.
Journal of experimental & clinical cancer research : CR 2002;21(2):197-201.
2002: Shibutani Makoto; Takahashi Noriyuki; Kobayashi Tsuneo; Uneyama Chikako; Masutomi Naoya; Nishikawa Akiyoshi; Hirose Masao
Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay.
Carcinogenesis 2002;23(6):1047-55.
2002: Takizawa Tamotsu; Imai Toshio; Mitsumori Kunitoshi; Takagi Hisayoshi; Onodera Hiroshi; Yasuhara Kazuo; Ueda Makoto; Tamura Toru; Hirose Masao
Gonadal toxicity of an ethanol extract of Psoralea corylifolia in a rat 90-day repeated dose study.
The Journal of toxicological sciences 2002;27(2):97-105.
2002: Niho N; Shibutani M; Toyoda K; Sato H; Hirose A; Imaida K; Takahashi M; Hayashi Y; Hirose M
Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(5):715-22.
2002: Futakuchi Mitsuru; Cheng Jing Lei; Hirose Masao; Kimoto Naoya; Cho Young Man; Iwata Toshio; Kasai Masaaki; Tokudome Shinkan; Shirai Tomoyuki
Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Cancer letters 2002;178(2):131-9.
2002: Furukawa Fumio; Nishikawa Akiyoshi; Chihara Takeshi; Shimpo Kan; Beppu Hidehiko; Kuzuya Hiroshi; Lee In Seon; Hirose Masao
Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
Cancer letters 2002;178(2):117-22.
2002: Miyauchi Makoto; Nakamura Hideaki; Furukawa Fumio; Son Hwa Young; Nishikawa Akiyoshi; Hirose Masao
Promoting effects of combined antioxidant and sodium nitrite treatment on forestomach carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer letters 2002;178(1):19-24.
2002: Takagi Hisayoshi; Mitsumori Kunitoshi; Onodera Hiroshi; Nasu Masahiro; Tamura Toru; Yasuhara Kazuo; Takegawa Kiyoshi; Hirose Masao
Improvement of a two-stage carcinogenesis model to detect modifying effects of endocrine disrupting chemicals on thyroid carcinogenesis in rats.
Cancer letters 2002;178(1):1-9.
2002: Nakamura Hideaki; Nishikawa Akiyoshi; Furukawa Fumio; Kasahara Ken-Ichiro; Miyauchi Makoto; Okazaki Kazushi; Imazawa Takayoshi; Uchida Koji; Hirose Masao
Enhancing effects of oltipraz on the development of spontaneous hepatic lesions in LEC rats.
Toxicologic pathology 2002;30(2):173-7.
2002: Futakuchi Mitsuru; Hirose Masao; Imaida Katsumi; Takahashi Satoru; Ogawa Kumiko; Asamoto Makoto; Miki Tokutaro; Shirai Tomoyuki
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.
Carcinogenesis 2002;23(2):283-7.
2002: Okazaki Kazushi; Imazawa Takayoshi; Nakamura Hideaki; Furukawa Fumio; Nishikawa Akiyoshi; Hirose Masao
A repeated 28-day oral dose toxicity study of 17alpha-methyltestosterone in rats, based on the 'enhanced OECD Test Guideline 407' for screening the endocrine-disrupting chemicals.
Archives of toxicology 2002;75(11-12):635-42.
2002: Nishikawa Akiyoshi; Furukawa Fumio; Miyauchi Makoto; Son Hwa-Young; Okazaki Kazushi; Koide Akihiro; Mori Yukio; Hirose Masao
Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2.
Japanese journal of cancer research : Gann 2002;93(1):24-31.
2002: Imai Toshio; Yasuhara Kazuo; Tamura Toru; Takizawa Tamotsu; Ueda Makoto; Hirose Masao; Mitsumori Kunitoshi
Inhibitory effects of cinnamaldehyde on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung carcinogenesis in rasH2 mice.
Cancer letters 2002;175(1):9-16.
2002: Okazaki Kazushi; Yamagishi Megumi; Son Hwa-Young; Imazawa Takayoshi; Furukawa Fumio; Nakamura Hideaki; Nishikawa Akiyoshi; Masegi Toshiaki; Hirose Masao
Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Nutrition and cancer 2002;42(2):211-6.
2002: Hirose Masao; Nishikawa Akiyoshi; Shibutani Makoto; Imai Toshio; Shirai Tomoyuki
Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats.
Environmental and molecular mutagenesis 2002;39(2-3):271-8.
2001: Masutomi N; Toyoda K; Shibutani M; Niho N; Uneyama C; Takahashi N; Hirose M
Toxic effects of benzyl and allyl isothiocyanates and benzyl-isoform specific metabolites in the urinary bladder after a single intravesical application to rats.
Toxicologic pathology 2001;29(6):617-22.
2001: Niho N; Shibutani M; Tamura T; Toyoda K; Uneyama C; Takahashi N; Hirose M
Subchronic toxicity study of gallic acid by oral administration in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(11):1063-70.
2001: Koujitani T; Yasuhara K; Tamura T; Onodera H; Takagi H; Takizawa T; Hirose M; Hayashi Y; Mitsumori K
Lack of modifying effects of eugenol on development of lung proliferative lesions induced by urethane in transgenic mice carrying the human prototype c-Ha-ras gene.
The Journal of toxicological sciences 2001;26(3):129-39.
2001: Nakamura H; Furukawa F; Nishikawa A; Miyauchi M; Son H Y; Imazawa T; Hirose M
Oral toxicity of a tocotrienol preparation in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(8):799-805.
2001: Shoda T; Yasuhara K; Moriyasu M; Takahashi T; Uneyama C; Hirose M; Mitsumori K
Testicular toxicity of nitrofurazone causing germ cell apoptosis in rats.
Archives of toxicology 2001;75(5):297-305.
2001: Hirose M; Hoshiya T; Mizoguchi Y; Nakamura A; Akagi K; Shirai T
Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2'-dihydroxy-di-n-propylnitrosamine in male F344 rats.
Cancer letters 2001;168(1):23-9.
2001: Kimoto N; Hirose M; Futakuchi M; Iwata T; Kasai M; Shirai T
Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats.
Cancer letters 2001;168(1):15-21.
2001: Imazawa T; Nishikawa A; Shibutani M; Ogasawara H; Furukawa F; Ikeda T; Suda K; Hirose M
Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide.
Toxicologic pathology 2001;29(3):320-7.
2001: Koujitani T; Yasuhara K; Toyosawa K; Shimada A; Onodera H; Takagi H; Tamura T; Hirose M; Mitsumori K
Immunohistochemical and ultrastructural studies of 2,6-dimethylaniline-induced nasal proliferative lesions in a rat two-stage nasal carcinogenesis model initiated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicologic pathology 2001;29(3):300-7.
2001: Tamura T; Mitsumori K; Onodera H; Fujimoto N; Yasuhara K; Takegawa K; Takagi H; Hirose M
Dose-threshold for thyroid tumor-promoting effects of orally administered kojic acid in rats after initiation with N-bis(2-hydroxypropyl) nitrosamine.
The Journal of toxicological sciences 2001;26(2):85-94.
2001: Ikeda T; Nishikawa A; Son H Y; Nakamura H; Miyauchi M; Imazawa T; Kimura S; Hirose M
Synergistic effects of high-dose soybean intake with iodine deficiency, but not sulfadimethoxine or phenobarbital, on rat thyroid proliferation.
Japanese journal of cancer research : Gann 2001;92(4):390-5.
2001: Yasuhara K; Koujitani T; Takegawa K; Nasu M; Onodera H; Takagi H; Hirose M; Mitsumori K
Promoting effects of xylazine on development of thyroid tumors in rats initiated with N-bis(2-hydroxypropyl)nitrosamine and the mechanism of action.
Carcinogenesis 2001;22(4):613-8.
2001: Hagiwara A; Takesada Y; Tanaka H; Tamano S; Hirose M; Ito N; Shirai T
Dose-dependent induction of glandular stomach preneoplastic and neoplastic lesions in male F344 rats treated with catechol chronically.
Toxicologic pathology 2001;29(2):180-6.
2001: Nishikawa A; Suzuki T; Masumura K; Furukawa F; Miyauchi M; Nakamura H; Son H Y; Nohmi T; Hayashi M; Hirose M
Reporter gene transgenic mice as a tool for analyzing the molecular mechanisms underlying experimental carcinogenesis.
Journal of experimental & clinical cancer research : CR 2001;20(1):111-5.
2001: Son H Y; Nishikawa A; Ikeda T; Imazawa T; Kimura S; Hirose M
Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet.
Japanese journal of cancer research : Gann 2001;92(2):103-8.
2001: Ogawa K; Hirose M; Sugiura S; Cui L; Imaida K; Ogiso T; Shirai T
Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis.
Nutrition and cancer 2001;40(2):134-9.
2000: Son H Y; Nishikawa A; Furukawa F; Lee I S; Ikeda T; Miyauchi M; Nakamura H; Hirose M
Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters.
Cancer letters 2000;160(2):141-7.
2000: Mitsumori K; Shimo T; Onodera H; Takagi H; Yasuhara K; Tamura T; Aoki Y; Nagata O; Hirose M
Modifying effects of ethinylestradiol but not methoxychlor on N-ethyl-N-nitrosourea-induced uterine carcinogenesis in heterozygous p53-deficient CBA mice.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(1):43-9.
2000: Son H Y; Nishikawa A; Ikeda T; Furukawa F; Hirose M
Lack of modification by environmental estrogenic compounds of thyroid carcinogenesis in ovariectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Japanese journal of cancer research : Gann 2000;91(10):966-72.
2000: Furukawa F; Nishikawa A; Nakamura H; Miyauchi M; Son H; Hirose M
Effects of octreotide, a somatostatin analogue, on initiation of pancreatic carcinogenesis in hamsters with N-nitrosobis(2-oxopropyl)amine.
Cancer letters 2000;159(1):43-8.
2000: Nakamura H; Nishikawa A; Furukawa F; Kasahara K; Miyauchi M; Son H Y; Hirose M
Inhibitory effects of protocatechuic acid on the post-initiation phase of hamster pancreatic carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine.
Anticancer research 2000;20(5B):3423-7.
2000: Takegawa K; Mitsumori K; Yasuhara K; Moriyasu M; Sakamori M; Onodera H; Hirose M; Nomura T
A mechanistic study of ovarian carcinogenesis induced by nitrofurazone using rasH2 mice.
Toxicologic pathology 2000;28(5):649-55.
2000: Son H Y; Nishikawa A; Ikeda T; Nakamura H; Miyauchi M; Imazawa T; Furukawa F; Hirose M
Lack of modifying effects of environmental estrogenic compounds on the development of thyroid proliferative lesions in male rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Japanese journal of cancer research : Gann 2000;91(9):899-905.
2000: Takegawa K; Mitsumori K; Onodera H; Shimo T; Kitaura K; Yasuhara K; Hirose M; Takahashi M
Studies on the carcinogenicity of potassium iodide in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(9):773-81.
2000: Koujitani T; Yasuhara K; Ikeda T; Imazawa T; Tamura T; Toyosawa K; Shimada A; Hirose M; Mitsumori K
Sequential observation of 2,6-dimethylaniline-induced nasal lesions in a rat two-stage nasal carcinogenesis model after initiation with N-bis(2-hydroxypropyl) nitrosamine.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2000;62(7):751-6.
2000: Shoda T; Mitsumori K; Onodera H; Toyoda K; Uneyama C; Takada K; Hirose M
Liver tumor-promoting effect of beta-naphthoflavone, a strong CYP 1A1/2 inducer, and the relationship between CYP 1A1/2 induction and Cx32 decrease in its hepatocarcinogenesis in the rat.
Toxicologic pathology 2000;28(4):540-7.
2000: Imazawa T; Nishikawa A; Todate A; Furukawa F; Onodera H; Mitsumori K; Hirose M; Hayashi Y
Dual effects of prolonged ACTH stimulation on 4-hydroxyaminoquinoline 1-oxide-induced adrenocortical lesions in rats.
Toxicologic pathology 2000;28(4):535-9.
2000: Hirose M; Yamaguchi T; Lin C; Kimoto N; Futakuchi M; Kono T; Nishibe S; Shirai T
Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats.
Cancer letters 2000;155(1):79-88.
2000: Furukawa F; Nishikawa A; Miyauchi M; Nakamura H; Son H Y; Yamagishi M; Hirose M
Concurrent administration of fish meal and sodium nitrite does not promote renal carcinogenesis in rats after initiation with N-ethyl-N-hydroxyethylnitrosamine.
Cancer letters 2000;154(1):45-51.
2000: Toyoda K; Shibutani M; Tamura T; Koujitani T; Uneyama C; Hirose M
Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the 'Enhanced OECD Test Guideline 407' for screening for endocrine-disrupting chemicals.
Archives of toxicology 2000;74(3):127-32.
2000: Yasuhara K; Kobayashi H; Shimamura Y; Koujitani T; Onodera H; Takagi H; Hirose M; Mitsumori K
Toxicity and blood concentrations of xylazine and its metabolite, 2,6-dimethylaniline, in rats after single or continuous oral administrations.
The Journal of toxicological sciences 2000;25(2):105-13.
2000: Miyauchi M; Nishikawa A; Furukawa F; Nakamura H; Son H Y; Murakami A; Koshimizu K; Ohigashi H; Hirose M
Inhibitory effects of 1'-acetoxychavicol acetate on N-Nitrosobis(2-oxopropyl)-amine-induced initiation of cholangiocarcinogenesis in Syrian hamsters.
Japanese journal of cancer research : Gann 2000;91(5):477-81.
2000: Mitsumori K; Onodera H; Shimo T; Yasuhara K; Takagi H; Koujitani T; Hirose M; Maruyama C; Wakana S
Rapid induction of uterine tumors with p53 point mutations in heterozygous p53-deficient CBA mice given a single intraperitoneal administration of N-ethyl-N-nitrosourea.
Carcinogenesis 2000;21(5):1039-42.
2000: Son H Y; Nishikawa A; Furukawa F; Kasahara K I; Miyauchi M; Nakamura H; Ikeda T; Hirose M
Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters.
Cancer letters 2000;153(1-2):211-8.
2000: Koujitani T; Yasuhara K; Usui T; Nomura T; Onodera H; Takagi H; Hirose M; Mitsumori K
Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study.
Cancer letters 2000;152(2):211-6.
2000: Furukawa F; Nishikawa A; Lee I S; Son H Y; Nakamura H; Miyauchi M; Takahashi M; Hirose M
Inhibition by methionine of pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl) amine.
Cancer letters 2000;152(2):163-7.
2000: Ikeda T; Nishikawa A; Imazawa T; Kimura S; Hirose M
Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia.
Carcinogenesis 2000;21(4):707-13.
2000: Imazawa T; Nishikawa A; Furukawa F; Kasahara K; Ikeda T; Takahashi M; Hirose M
Lack of carcinogenicity of gardenia blue colour given chronically in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(4):313-8.
2000: Furukawa F; Nishikawa A; Ishiwata H; Takahashi M; Hayashi Y; Hirose M
Renal carcinogenicity of concurrently administered fish meal and sodium nitrite in F344 rats.
Japanese journal of cancer research : Gann 2000;91(2):139-47.
2000: Toyoda K; Shibutani M; Sato H; Uneyama C; Takahashi M; Hayashi Y; Hirose M
Lack of carcinogenicity and increased survival in F344 rats treated with 5-fluorouracil for two years.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(2-3):187-93.
2000: Shibutani M; Uneyama C; Miyazaki K; Toyoda K; Hirose M
Methacarn fixation: a novel tool for analysis of gene expressions in paraffin-embedded tissue specimens.
Laboratory investigation; a journal of technical methods and pathology 2000;80(2):199-208.
2000: Imazawa T; Mitsumori K; Kitajima S; Onodera H; Tamura T; Takahashi M; Hirose M
Time course of ultrastructural changes and immunoelectron microscopic localization of neurocalcin in motor endplates of the lumbrical muscles of rats given a single administration of 2,5-di(tert-butyl)-1,4-hydroquinone.
Acta neuropathologica 2000;99(2):109-16.
2000: Nishikawa A; Furukawa F; Kasahara K; Ikezaki S; Itoh T; Suzuki T; Uchida K; Kurihara M; Hayashi M; Miyata N; Hirose M
Trans-4-hydroxy-2-nonenal, an aldehydic lipid peroxidation product, lacks genotoxicity in lacI transgenic mice.
Cancer letters 2000;148(1):81-6.
2000: Masutomi N; Shibutani M; Toyoda K; Niho N; Uneyama C; Hirose M
[A 90-day repeated dose toxicity study of madder color in F344 rats: a preliminary study for chronic toxicity and carcinogenicity studies]
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 2000;(118):55-62.
2000: Kawabe M; Lin C; Kimoto N; Sano M; Hirose M; Shirai T
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
Nutrition and cancer 2000;37(2):179-86.
1999: Kimoto N; Hirose M; Kawabe M; Satoh T; Miyataka H; Shirai T
Post-initiation effects of a super critical extract of propolis in a rat two-stage carcinogenesis model in female F344 rats.
Cancer letters 1999;147(1-2):221-7.
1999: Futakuchi M; Hirose M; Ogiso T; Kato K; Sano M; Ogawa K; Shirai T
Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model.
Japanese journal of cancer research : Gann 1999;90(11):1196-202.
1999: Hirose M; Fukushima S; Imaida K; Ito N; Shirai T
Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis.
Anticancer research 1999;19(5A):3665-70.
1999: Shoda T; Mitsumori K; Onodera H; Toyoda K; Uneyama C; Imazawa T; Hirose M
The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat.
Archives of toxicology 1999;73(7):373-80.
1999: Hirose M; Takahashi S; Ogawa K; Futakuchi M; Shirai T
Phenolics: blocking agents for heterocyclic amine-induced carcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(9-10):985-92.
1999: Shoda T; Onodera H; Takeda M; Uneyama C; Imazawa T; Takegawa K; Yasuhara K; Watanabe T; Hirose M; Mitsumori K
Liver tumor promoting effects of fenbendazole in rats.
Toxicologic pathology 1999;27(5):553-62.
1999: Hirose M; Takahashi S; Ogawa K; Futakuchi M; Shirai T; Shibutani M; Uneyama C; Toyoda K; Iwata H
Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats.
Cancer letters 1999;143(2):173-8.
1999: Tamura T; Mitsumori K; Onodera H; Takahashi M; Funakoshi T; Yasuhara K; Takegawa K; Takagi H; Hirose M
Time course observation of thyroid proliferative lesions and serum levels of related hormones in rats treated with kojic acid after DHPN initiation.
The Journal of toxicological sciences 1999;24(3):145-55.
1999: Tamura T; Shibutani M; Toyoda K; Shoda T; Takada K; Uneyama C; Takahashi M; Hirose M
Tumor-promoting activities of hydroquinone and 1,1-dimethylhydrazine after initiation of newborn mice with 1-methyl-1-nitrosourea.
Cancer letters 1999;143(1):71-80.
1999: Koujitani T; Yasuhara K; Kobayashi H; Shimada A; Onodera H; Takagi H; Hirose M; Mitsumori K
Tumor-promoting activity of 2,6-dimethylaniline in a two-stage nasal carcinogenesis model in N-bis(2-hydroxypropyl)nitrosamine-treated rats.
Cancer letters 1999;142(2):161-71.
1999: Hirose M; Hakoi K; Takahashi S; Hoshiya T; Akagi K; Lin C; Saito K; Kaneko H; Shirai T
Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats.
Toxicologic pathology 1999;27(4):448-55.
1999: Nishikawa A; Furukawa F; Kasahara K; Tanakamaru Z; Miyauchi M; Nakamura H; Ikeda T; Imazawa T; Hirose M
Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase.
Cancer letters 1999;141(1-2):109-15.
1999: Miyauchi M; Nishikawa A; Furukawa F; Kasahara K; Nakamura H; Takahashi M; Hirose M
Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay.
Cancer letters 1999;142(1):75-81.
1999: Ikezaki S; Nishikawa A; Furukawa F; Tanakamaru Z; Nakamura H; Mori H; Hirose M
Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats.
The Journal of toxicological sciences 1999;24(2):133-9.
1999: Nishikawa A; Furukawa F; Lee I S; Kasahara K; Tanakamaru Z; Nakamura H; Miyauchi M; Kinae N; Hirose M
Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer research 1999;59(9):2045-9.
1999: Hagiwara A; Boonyaphiphat P; Tanaka H; Kawabe M; Tamano S; Kaneko H; Matsui M; Hirose M; Ito N; Shirai T
Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344 rats.
Japanese journal of cancer research : Gann 1999;90(4):399-405.
1999: Furukawa F; Nishikawa A; Kasahara K; Lee I S; Wakabayashi K; Takahashi M; Hirose M
Inhibition by beta-carotene of upper respiratory tumorigenesis in hamsters receiving diethylnitrosamine followed by cigarette smoke exposure.
Japanese journal of cancer research : Gann 1999;90(2):154-61.
1999: Niho N; Tamura T; Toyoda K; Uneyama C; Shibutani M; Hirose M
[A 13-week subchronic toxicity study of chitin in F344 rats]
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences 1999;(117):129-34.
1999: Shirai T; Hirose M; Ito N
Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals.
IARC scientific publications 1999;(146):251-72.
1998: Ito N; Imaida K; Hirose M; Shirai T
Medium-term bioassays for carcinogenicity of chemical mixtures.
Environmental health perspectives 1998;106 Suppl 6():1331-6.
1998: Takahashi S; Tamano S; Hirose M; Kimoto N; Ikeda Y; Sakakibara M; Tada M; Kadlubar F F; Ito N; Shirai T
Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): detection in paraffin-embedded sections and tissue distribution.
Cancer research 1998;58(19):4307-13.
1998: Hirose M; Yamaguchi T; Kimoto N; Ogawa K; Futakuchi M; Sano M; Shirai T
Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats.
International journal of cancer. Journal international du cancer 1998;77(5):773-7.
1998: Hirose M; Ito T; Takahashi S; Ozaki M; Ogiso T; Nihro Y; Miki T; Shirai T
Prevention by synthetic phenolic antioxidants of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)- or activated MeIQx-induced mutagenesis and MeIQx-induced rat hepatocarcinogenesis, and role of antioxidant activity in the prevention of carcinogenesis.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(3):233-41.
1998: Ogawa K; Futakuchi M; Hirose M; Boonyaphiphat P; Mizoguchi Y; Miki T; Shirai T
Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model.
International journal of cancer. Journal international du cancer 1998;76(6):851-6.
1998: Mizoguchi Y; Hirose M; Yamaguchi T; Boonyaphiphat P; Miki T; Shirai T
Dose dependence of 1-O-hexyl-2,3,5-trimethylhydroquinone promotion of forestomach carcinogenesis in rats pretreated with N-ethylnitrosourethane.
Japanese journal of cancer research : Gann 1998;89(5):475-80.
1998: Futakuchi M; Hirose M; Miki T; Tanaka H; Ozaki M; Shirai T
Inhibition of DMBA-initiated rat mammary tumour development by 1-O-hexyl-2,3,5-trimethylhydroquinone, phenylethyl isothiocyanate, and novel synthetic ascorbic acid derivatives.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(2):153-9.
1998: Tamano S; Hirose M; Tanaka H; Hagiwara A; Shirai T
Variation in susceptibility to the induction of forestomach tumours by butylated hydroxyanisole among rats of different strains.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(4):299-304.
1998: Kato T; Hirose M; Takahashi S; Hasegawa R; Kohno T; Nishibe S; Kato K; Shirai T
Effects of the lignan, arctiin, on 17-beta ethinyl estradiol promotion of preneoplastic liver cell foci development in rats.
Anticancer research 1998;18(2A):1053-7.
1998: Takahashi S; Hirose M; Tamano S; Ozaki M; Orita S; Ito T; Takeuchi M; Ochi H; Fukada S; Kasai H; Shirai T
Immunohistochemical detection of 8-hydroxy-2'-deoxyguanosine in paraffin-embedded sections of rat liver after carbon tetrachloride treatment.
Toxicologic pathology 1998;26(2):247-52.
1998: Hirose M; Futakuchi M; Tanaka H; Orita S I; Ito T; Miki T; Shirai T
Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(1):61-7.
1998: Wada S; Hirose M; Shichino Y; Ozaki K; Hoshiya T; Kato K; Shirai T
Effects of catechol, sodium chloride and ethanol either alone or in combination on gastric carcinogenesis in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer letters 1998;123(2):127-34.
1998: Hirose M; Takesada Y; Tanaka H; Tamano S; Kato T; Shirai T
Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model.
Carcinogenesis 1998;19(1):207-12.
1997: Hirose M; Shirai T; Lee M S; Wang C Y; King C M
Carcinogenecity of the N-acyl derivatives of N-hydroxy-trans-4-aminostilbene in CD rats.
Chemico-biological interactions 1997;106(2):123-32.
1997: Tanaka H; Hirose M; Kawabe M; Sano M; Takesada Y; Hagiwara A; Shirai T
Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats.
Cancer letters 1997;116(1):47-52.
1997: Ito N; Hasegawa R; Imaida K; Tamano S; Hagiwara A; Hirose M; Shirai T
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
Mutation research 1997;376(1-2):107-14.
1997: Takaba K; Hirose M; Yoshida Y; Kimura J; Ito N; Shirai T
Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model.
Cancer letters 1997;113(1-2):39-46.
1997: Hirose M; Mizoguchi Y; Yaono M; Tanaka H; Yamaguchi T; Shirai T
Effects of green tea catechins on the progression or late promotion stage of mammary gland carcinogenesis in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene.
Cancer letters 1997;112(2):141-7.
1997: Shirai T; Sano M; Tamano S; Takahashi S; Hirose M; Futakuchi M; Hasegawa R; Imaida K; Matsumoto K; Wakabayashi K; Sugimura T; Ito N
The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.
Cancer research 1997;57(2):195-8.
1996: Hasegawa R; Kato T; Hirose M; Takahashi S; Shirai T; Ito N
Enhancement of hepatocarcinogenesis by combined administration of food-derived heterocyclic amines at low doses in the rat.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(11-12):1097-101.
1996: Imaida K; Hagiwara A; Yada H; Masui T; Hasegawa R; Hirose M; Sugimura T; Ito N; Shirai T
Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.
Japanese journal of cancer research : Gann 1996;87(11):1116-20.
1996: Futakuchi M; Lijinsky W; Hasegawa R; Hirose M; Ito N; Shirai T
Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat.
Cancer letters 1996;106(2):263-9.
1996: Kimura J; Takahashi S; Ogiso T; Yoshida Y; Akagi K; Hasegawa R; Kurata M; Hirose M; Shirai T
Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model.
Japanese journal of cancer research : Gann 1996;87(6):589-94.
1996: Hagiwara A; Miyata E; Tamano S; Shibata M A; Sugiura S; Inoue M; Hirose M
Non-carcinogenicity of 2,2'--(4-aminophenyl)imino-bisethanol sulfate in a long-term feeding study in Fischer 344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(6):537-46.
1996: Tanaka H; Hasegawa R; Takesada Y; Ogiso T; Hirose M; Shirai T
Effects of carbamate insecticides in a rat medium-term bioassay for hepatocarcinogens.
Journal of toxicology and environmental health 1996;47(5):493-8.
1996: Ito N; Hasegawa R; Imaida K; Hirose M; Shirai T
Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(2-3):113-9.
1996: Kato T; Hasegawa R; Nakae D; Hirose M; Yaono M; Cui L; Kobayashi Y; Konishi Y; Ito N; Shirai T
Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
Japanese journal of cancer research : Gann 1996;87(2):127-33.
1996: Hagiwara A; Kokubo Y; Takesada Y; Tanaka H; Tamano S; Hirose M; Shirai T; Ito N
Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats.
Teratogenesis, carcinogenesis, and mutagenesis 1996;16(6):317-25.
1995: Hirose M; Hasegawa R; Kimura J; Akagi K; Yoshida Y; Tanaka H; Miki T; Satoh T; Wakabayashi K; Ito N
Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Carcinogenesis 1995;16(12):3049-55.
1995: Ito N; Hagiwara A; Tamano S; Hasegawa R; Imaida K; Hirose M; Shirai T
Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats.
Toxicology letters 1995;82-83():513-20.
1995: Ito N; Hasegawa R; Imaida K; Hirose M; Asamoto M; Shirai T
Concepts in multistage carcinogenesis.
Critical reviews in oncology/hematology 1995;21(1-3):105-133.
1995: Shibata M; Hasegawa R; Imaida K; Hagiwara A; Ogawa K; Hirose M; Ito N; Shirai T
Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.
Cancer research 1995;55(21):4870-4.
1995: Hasegawa R; Hirose M; Kato T; Hagiwara A; Boonyaphiphat P; Nagao M; Ito N; Shirai T
Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats.
Carcinogenesis 1995;16(9):2243-6.
1995: Hirose M; Iwata S; Ito E; Nihro Y; Takahashi S; Mizoguchi Y; Miki T; Satoh T; Ito N; Shirai T
Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole (Glu-p-1).
Carcinogenesis 1995;16(9):2227-32.
1995: Akagi K; Hirose M; Hoshiya T; Mizoguchi Y; Ito N; Shirai T
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Cancer letters 1995;94(1):113-21.
1995: Shirai T; Tamano S; Sano M; Imaida K; Hagiwara A; Futakuchi M; Takahashi S; Hirose M
Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2'-dimethyl-4-aminobiphenyl: dose-dependent induction of invasive carcinomas.
Japanese journal of cancer research : Gann 1995;86(7):645-8.
1995: Masui T; Shirai T; Imaida K; Hirose M; Futakuchi M; Tatematsu M; Ito N
Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2'-dimethyl-4-aminobiphenyl.
Molecular carcinogenesis 1995;13(1):21-6.
1995: Shirai T; Shibata M; Takahashi S; Tagawa Y; Imaida K; Hirose M
Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated.
Carcinogenesis 1995;16(3):501-5.
1995: Tanaka H; Hirose M; Hagiwara A; Imaida K; Shirai T; Ito N
Rat strain differences in catechol carcinogenicity to the stomach.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(2):93-8.
1995: Hirose M; Akagi K; Hasegawa R; Yaono M; Satoh T; Hara Y; Wakabayashi K; Ito N
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats.
Carcinogenesis 1995;16(2):217-21.
1995: Ito N; Hasegawa R; Asakawa E; Hirose M; Imaida K; Hagiwara A
Enhancement of rat liver cell foci development by combined treatment with heterocyclic amines at low doses.
Princess Takamatsu symposia 1995;23():251-9.
1994: Hirose M; Hoshiya T; Akagi K; Futakuchi M; Ito N
Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene.
Cancer letters 1994;83(1-2):149-56.
1994: Takaba K; Hirose M; Ogawa K; Hakoi K; Fukushima S
Modification of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(6):499-503.
1994: Asakawa E; Hirose M; Hagiwara A; Takahashi S; Ito N
Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats.
International journal of cancer. Journal international du cancer 1994;56(1):146-52.
1994: Yoshida Y; Hirose M; Takaba K; Kimura J; Ito N
Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methyl-N'-nitro-N-nitrosoguanidine pre-treatment.
International journal of cancer. Journal international du cancer 1994;56(1):124-8.
1994: Kawabe M; Takaba K; Yoshida Y; Hirose M
Effects of combined treatment with phenolic compounds and sodium nitrite on two-stage carcinogenesis and cell proliferation in the rat stomach.
Japanese journal of cancer research : Gann 1994;85(1):17-25.
1993: Ito N; Hirose M; Takahashi S
Cell proliferation and forestomach carcinogenesis.
Environmental health perspectives 1993;101 Suppl 5():107-10.
1993: Kagawa M; Hakoi K; Yamamoto A; Futakuchi M; Hirose M
Comparison of reversibility of rat forestomach lesions induced by genotoxic and non-genotoxic carcinogens.
Japanese journal of cancer research : Gann 1993;84(11):1120-9.
1993: Hirose M; Yada H; Hakoi K; Takahashi S; Ito N
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
Carcinogenesis 1993;14(11):2359-64.
1993: Hirose M; Hoshiya T; Akagi K; Takahashi S; Hara Y; Ito N
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Carcinogenesis 1993;14(8):1549-53.
1993: Kawabe M; Tamano S; Shibata M A; Hirose M; Fukushima S; Ito N
Subchronic toxicity study of methyl hesperidin in mice.
Toxicology letters 1993;69(1):37-44.
1993: Tatematsu M; Ichinose M; Tsukada S; Kakei N; Takahashi S; Ogawa K; Hirose M; Furihata C; Miki K; Kurokawa K
DNA methylation of the pepsinogen 1 gene during rat glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine or catechol.
Carcinogenesis 1993;14(7):1415-9.
1993: Shibata M A; Hirose M; Masuda A; Kato T; Mutai M; Ito N
Modification of BHA forestomach carcinogenesis in rats: inhibition by diethylmaleate or indomethacin and enhancement by a retinoid.
Carcinogenesis 1993;14(7):1265-9.
1993: Hirose M; Akagi K; Hasegawa R; Satoh T; Nihro Y; Miki T; Sugimura T; Ito N
Strong inhibition of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone.
Japanese journal of cancer research : Gann 1993;84(5):481-4.
1993: Hirose M; Fukushima S; Tanaka H; Asakawa E; Takahashi S; Ito N
Carcinogenicity of catechol in F344 rats and B6C3F1 mice.
Carcinogenesis 1993;14(3):525-9.
1993: Shibata M A; Shirai T; Asakawa E; Hirose M; Fukushima S
Inhibition by dehydroepiandrosterone of butylated hydroxyanisole (BHA) promotion of rat-bladder carcinogenesis and enhancement of BHA-induced forestomach hyperplasia.
International journal of cancer. Journal international du cancer 1993;53(5):819-23.
1993: Shibata M A; Hirose M; Kagawa M; Boonyaphiphat P; Ito N
Enhancing effect of concomitant L-ascorbic acid administration on BHA-induced forestomach carcinogenesis in rats.
Carcinogenesis 1993;14(2):275-80.
1993: Hirose M; Tanaka H; Takahashi S; Futakuchi M; Fukushima S; Ito N
Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model.
Cancer research 1993;53(1):32-7.
1993: Hirose M; Shirai T; Takahashi S; Ogawa K; Ito N
Organ-specific modification of carcinogenesis by antioxidants in rats.
Basic life sciences 1993;61():181-8.
1993: Okazaki S; Hoshiya T; Takahashi S; Futakuchi M; Saito K; Hirose M
Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.
Teratogenesis, carcinogenesis, and mutagenesis 1993;13(3):127-37.
1992: Tamano S; Hirose M; Tanaka H; Asakawa E; Ogawa K; Ito N
Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol.
Japanese journal of cancer research : Gann 1992;83(12):1279-85.
1992: Hirose M; Kawabe M; Shibata M; Takahashi S; Okazaki S; Ito N
Influence of caffeic acid and other o-dihydroxybenzene derivatives on N-methyl-N'-nitro-N-nitrosoguanidine-initiated rat forestomach carcinogenesis.
Carcinogenesis 1992;13(10):1825-8.
1992: Takahashi S; Hakoi K; Yada H; Hirose M; Ito N; Fukushima S
Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats.
Carcinogenesis 1992;13(9):1513-8.
1992: Hasegawa R; Tiwawech D; Hirose M; Takaba K; Hoshiya T; Shirai T; Ito N
Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses.
Japanese journal of cancer research : Gann 1992;83(5):431-7.
1992: Hirose M; Wada S; Yamaguchi S; Masuda A; Okazaki S; Ito N
Reversibility of catechol-induced rat glandular stomach lesions.
Cancer research 1992;52(4):787-90.
1992: Shibata M A; Fukushima S; Asakawa E; Hirose M; Ito N
The modifying effects of indomethacin or ascorbic acid on cell proliferation induced by different types of bladder tumor promoters in rat urinary bladder and forestomach mucosal epithelium.
Japanese journal of cancer research : Gann 1992;83(1):31-9.
1992: Hagiwara A; Asakawa E; Kurata Y; Sano M; Hirose M; Ito N
Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats.
Toxicologic pathology 1992;20(2):197-204.
1991: Shibata M A; Hirose M; Tanaka H; Asakawa E; Shirai T; Ito N
Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment.
Japanese journal of cancer research : Gann 1991;82(11):1211-9.
1991: Hirose M; Uwagawa S; Ozaki K; Takaba K; Ito N
Effects of butylated hydroxyanisole pretreatment on low dose N-methyl-N'-nitro-N-nitrosoguanidine- or N,N-dibutylnitrosamine-induced rat forestomach or esophageal carcinogenesis.
Carcinogenesis 1991;12(10):1773-6.
1991: Hagiwara A; Hirose M; Takahashi S; Ogawa K; Shirai T; Ito N
Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6N x C3H/HeN F1 mice.
Cancer research 1991;51(20):5655-60.
1991: Hirose M; Ozaki K; Takaba K; Fukushima S; Shirai T; Ito N
Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model.
Carcinogenesis 1991;12(10):1917-21.
1991: Fukushima S; Shibata M A; Hirose M; Kato T; Tatematsu M; Ito N
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Japanese journal of cancer research : Gann 1991;82(7):784-92.
1991: Nakamura A; Shirai T; Takahashi S; Ogawa K; Hirose M; Ito N
Lack of modification by naturally occurring antioxidants of 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.
Cancer letters 1991;58(3):241-6.
1991: Fukushima S; Hagiwara A; Hirose M; Yamaguchi S; Tiwawech D; Ito N
Modifying effects of various chemicals on preneoplastic and neoplastic lesion development in a wide-spectrum organ carcinogenesis model using F344 rats.
Japanese journal of cancer research : Gann 1991;82(6):642-9.
1991: Hirose M; Mutai M; Takahashi S; Yamada M; Fukushima S; Ito N
Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer research 1991;51(3):824-7.
1990: Imaida K; Hirose M; Yamaguchi S; Takahashi S; Ito N
Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis in F344 male rats.
Cancer letters 1990;55(1):53-9.
1990: Wada S; Hirose M; Takahashi S; Okazaki S; Ito N
Para-methoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis.
Carcinogenesis 1990;11(10):1891-4.
1990: Hasegawa R; Furukawa F; Toyoda K; Takahashi M; Hayashi Y; Hirose M; Ito N
Inhibitory effects of antioxidants on N-bis(2-hydroxypropyl)nitrosamine-induced lung carcinogenesis in rats.
Japanese journal of cancer research : Gann 1990;81(9):871-7.
1990: Hirose M; Fukushima S; Hasegawa R; Kato T; Tanaka H; Ito N
Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium.
Japanese journal of cancer research : Gann 1990;81(9):857-61.
1990: Kurata Y; Fukushima S; Hasegawa R; Hirose M; Shibata M; Shirai T; Ito N
Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants.
Japanese journal of cancer research : Gann 1990;81(8):754-9.
1990: Shibata M A; Hirose M; Yamada M; Tatematsu M; Uwagawa S; Ito N
Epithelial cell proliferation in rat forestomach and glandular stomach mucosa induced by catechol and analogous dihydroxybenzenes.
Carcinogenesis 1990;11(6):997-1000.
1990: Hirose M; Masuda A; Ito N; Kamano K; Okuyama H
Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats.
Carcinogenesis 1990;11(5):731-5.
1990: Shibata M A; Yamada M; Hirose M; Asakawa E; Tatematsu M; Ito N
Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants.
Carcinogenesis 1990;11(3):425-9.
1990: Hirose M; Fukushima S; Shirai T; Hasegawa R; Kato T; Tanaka H; Asakawa E; Ito N
Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice.
Japanese journal of cancer research : Gann 1990;81(3):207-12.
1990: Hirose M; Masuda A; Hasegawa R; Wada S; Ito N
Regression of butylated hydroxyanisole (BHA)-induced hyperplasia but not dysplasia in the forestomach of hamsters.
Carcinogenesis 1990;11(2):239-44.
1990: Ito N; Hirose M; Hagiwara A; Takahashi S
Carcinogenicity and modification of carcinogenic response by antioxidants.
Basic life sciences 1990;52():183-94.
1989: Ito N; Hirose M; Shibata M; Tanaka H; Shirai T
Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2'-dimethyl-4-aminobiphenyl, 2,2'-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea.
Carcinogenesis 1989;10(12):2255-9.
1989: Hirose M; Kagawa M; Ogawa K; Yamamoto A; Ito N
Antagonistic effect of diethylmaleate on the promotion of forestomach carcinogenesis by butylated hydroxyanisole (BHA) in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1989;10(12):2223-6.
1989: Yamaguchi S; Hirose M; Fukushima S; Hasegawa R; Ito N
Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine.
Cancer research 1989;49(21):6015-8.
1989: Hirose M; Yamaguchi S; Fukushima S; Hasegawa R; Takahashi S; Ito N
Promotion by dihydroxybenzene derivatives of N-methyl-N'-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis.
Cancer research 1989;49(18):5143-7.
1989: Hirose M; Kurata Y; Yamada M; Shirai T; Ito N; Ohsawa T
Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats.
Cancer letters 1989;47(1-2):141-7.
1989: Ito N; Hirose M
Antioxidants--carcinogenic and chemopreventive properties.
Advances in cancer research 1989;53():247-302.
1988: Imaida K; Fukushima S; Inoue K; Masui T; Hirose M; Ito N
Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats.
Cancer letters 1988;43(3):167-72.
1988: Hirose M; Hagiwara A; Inoue K; Ito N; Kaneko H; Saito K; Matsunaga H; Isobe N; Yoshitake A; Miyamoto J
Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces.
Toxicology 1988;53(1):33-43.
1988: Hirose M; Fukushima S; Kurata Y; Tsuda H; Tatematsu M; Ito N
Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats.
Cancer research 1988;48(18):5310-5.
1988: Fukushima S; Tamano S; Shibata M A; Kurata Y; Hirose M; Ito N
The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder.
Carcinogenesis 1988;9(7):1203-6.
1988: Hirose M; Masuda A; Fukushima S; Ito N
Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats.
Carcinogenesis 1988;9(1):101-4.
1987: Hirose M; Masuda A; Tsuda H; Uwagawa S; Ito N
Enhancement of BHA-induced proliferative rat forestomach lesion development by simultaneous treatment with other antioxidants.
Carcinogenesis 1987;8(11):1731-5.
1987: Hirose M; Kurata Y; Tsuda H; Fukushima S; Ito N
Catechol strongly enhances rat stomach carcinogenesis: a possible new environmental stomach carcinogen.
Japanese journal of cancer research : Gann 1987;78(11):1144-9.
1987: Shirai T; Fukushima S; Hirose M; Ohshima M; Ito N
Epithelial lesions of the urinary bladder in three hundred and thirteen autopsy cases.
Japanese journal of cancer research : Gann 1987;78(10):1073-80.
1987: Ito N; Hirose M
The role of antioxidants in chemical carcinogenesis.
Japanese journal of cancer research : Gann 1987;78(10):1011-26.
1987: Hirose M; Inoue T; Masuda A; Tsuda H; Ito N
Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia--complete inhibition by diethylmaleate in a 5-week feeding study.
Carcinogenesis 1987;8(10):1555-8.

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