FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Masao Hirose

Research Profile

Living Beings

Chemicals & Drugs

Concepts & Ideas

Physiology

Organ Size

Disorders

Co-author Network

Publications

TOP 3
Shigeaki Takami; Kumiko Ogawa; Young-Man Cho; Masao Hirose; Toshio Imai; Akiyoshi Nishikawa
Juvenile rats do not exhibit elevated sensitivity to acrylamide toxicity after oral administration for 12 weeks.
Hitoshi Fujimoto; Masao Hirose; Katsuhide Igarashi; Kaoru Inoue; Jun Kanno; Akiyoshi Nishikawa; Gye-Hyeong Woo; Makoto Shibutani
Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents.
Yoshio Ota; Toshifumi Oyamada; Shigeaki Takami; Young-Man Cho; Mai Hasumura; Masao Hirose; Toshio Imai; Akiyoshi Nishikawa; Kumiko Ogawa
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Masao Hirose (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Shigeaki Takami; Kumiko Ogawa; Young-Man Cho; Masao Hirose; Toshio Imai; Akiyoshi Nishikawa
Juvenile rats do not exhibit elevated sensitivity to acrylamide toxicity after oral administration for 12 weeks.
Journal of applied toxicology : JAT 2012;32(12):959-67.
2012: Hitoshi Fujimoto; Masao Hirose; Katsuhide Igarashi; Kaoru Inoue; Jun Kanno; Akiyoshi Nishikawa; Gye-Hyeong Woo; Makoto Shibutani
Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents.
Reproductive toxicology (Elmsford, N.Y.) 2012;34(1):93-100.
2012: Yoshio Ota; Toshifumi Oyamada; Shigeaki Takami; Young-Man Cho; Mai Hasumura; Masao Hirose; Toshio Imai; Akiyoshi Nishikawa; Kumiko Ogawa
Prostaglandin synthases influence thyroid follicular cell proliferation but not carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicological sciences : an official journal of the Society of Toxicology 2012;127(2):339-47.
2011: Young-Man Cho; Mai Hasumura; Masao Hirose; Toshio Imai; K Ogawa; S Takami; Akiyoshi Nishikawa
A 13-week subchronic toxicity study of hinokitiol administered in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011;49(8):1782-6.
2011: Mai Hasumura; Masao Hirose; Toshio Imai; Akiyoshi Nishikawa; Young-Man Cho; Makoto Ueda; Kumiko Ogawa
Toxic effects of a horseradish extract and allyl isothiocyanate in the urinary bladder after 13-week administration in drinking water to F344 rats.
The Journal of toxicological sciences 2011;36(6):763-74.
2011: Hitoshi Fujimoto; Gye-Hyeong Woo; Kaoru Inoue; Miwa Takahashi; Masao Hirose; Akiyoshi Nishikawa; Makoto Shibutani
Impaired oligodendroglial development by decabromodiphenyl ether in rat offspring after maternal exposure from mid-gestation through lactation.
Reproductive toxicology (Elmsford, N.Y.) 2011;31(1):86-94.
2010: Shigeaki Takami; Toshio Imai; Young-Man Cho; Masao Hirose; Akiyoshi Nishikawa
Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats.
The Journal of toxicological sciences 2010;35(1):57-68.
2009: Kaoru Inoue; Midori Yoshida; Miwa Takahashi; Hitoshi Fujimoto; Makoto Shibutani; Masao Hirose; Akiyoshi Nishikawa
Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay.
Cancer science 2009;100(12):2261-7.
2009: Makoto Shibutani; Gye-Hyeong Woo; Hitoshi Fujimoto; Yukie Saegusa; Miwa Takahashi; Kaoru Inoue; Masao Hirose; Akiyoshi Nishikawa
Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents.
Reproductive toxicology (Elmsford, N.Y.) 2009;28(3):297-307.
2009: Toshio Imai; Mai Hasumura; Young-Man Cho; Yoshio Ota; Shigeaki Takami; Masao Hirose; Akiyoshi Nishikawa
Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.
Cancer science 2009;100(10):1794-800.
2009: Young-Man Cho; Toshio Imai; Y Ito; S Takami; Mai Hasumura; T Yamazaki; Masao Hirose; Akiyoshi Nishikawa
A 13-week subchronic toxicity study of dietary administered saponin-rich and isoflavones-containing soybean extract in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(8):2150-6.
2009: Yoshio Ota; Toshio Imai; Jun-ichi Onose; Shigeaki Takami; Young-Man Cho; Masao Hirose; Akiyoshi Nishikawa
A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats.
The Journal of toxicological sciences 2009;34(3):305-13.
2009: Kaoru Inoue; Midori Yoshida; Miwa Takahashi; Hitoshi Fujimoto; Kuniyoshi Ohnishi; Koichi Nakashima; Makoto Shibutani; Masao Hirose; Akiyoshi Nishikawa
Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(4):752-9.
2009: Toshio Imai; Shigeaki Takami; Young-Man Cho; Masao Hirose; Akiyoshi Nishikawa
Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats.
Toxicology letters 2009;185(3):160-7.
2009: Kaoru Inoue; Midori Yoshida; Miwa Takahashi; Makoto Shibutani; Hironori Takagi; Masao Hirose; Akiyoshi Nishikawa
Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2009;47(1):184-91.
2008: Kaoru Inoue; Makoto Shibutani; Naoya Masutomi; Kazuhiro Toyoda; Hironori Takagi; Miwa Takahashi; Hitoshi Fujimoto; Masao Hirose; Akiyoshi Nishikawa
One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(10):3303-10.
2008: Masako Tasaki; Takashi Umemura; Tomoki Inoue; Toshiya Okamura; Yuichi Kuroiwa; Yuji Ishii; Machiko Maeda; Masao Hirose; Akiyoshi Nishikawa
Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 year.
Toxicology 2008;250(2-3):143-50.
2008: Yoshiko Sugita-Konishi; Atsutaka Kubosaki; Mika Takahashi; B J Park; Toshitsugu Tanaka; Kosuke Takatori; Masao Hirose; Makoto Shibutani
Nivalenol and the targeting of the female reproductive system as well as haematopoietic and immune systems in rats after 90-day exposure through the diet.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2008;25(9):1118-27.
2008: Takashi Umemura; Machiko Maeda; Aki Kijima; Yuji Ishii; Masako Tasaki; Toshiya Okamura; Tomoki Inoue; Masao Hirose; Akiyoshi Nishikawa
Lack of promotion activity of diacylglycerol oil on 4-nitroquinoline 1-oxide induced carcinogenesis in the oral cavity of SD rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(9):3206-12.
2008: Mayumi Kawabe; Mitsuru Futakuchi; Seiko Tamano; Tomoyuki Shirai; Masao Hirose
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesis model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(8):2758-63.
2008: Yuichi Kuroiwa; Masami Yamada; Keiko Matsui; Toshiya Okamura; Yuji Ishii; Ken-ichi Masumura; Masako Tasaki; Takashi Umemura; Kunitoshi Mitsumori; Takehiko Nohmi; Masao Hirose; Akiyoshi Nishikawa
Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium.
Toxicological sciences : an official journal of the Society of Toxicology 2008;104(2):274-82.
2008: S Takami; Toshio Imai; Mai Hasumura; Young-Man Cho; Jun-ichi Onose; Masao Hirose
Evaluation of toxicity of green tea catechins with 90-day dietary administration to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(6):2224-9.
2008: Jun-ichi Onose; Toshio Imai; Mai Hasumura; Makoto Ueda; Yoshihiro Ozeki; Masao Hirose
Evaluation of subchronic toxicity of dietary administered Cry1Ab protein from Bacillus thuringiensis var. Kurustaki HD-1 in F344 male rats with chemically induced gastrointestinal impairment.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(6):2184-9.
2008: Young-Man Cho; Toshio Imai; Yoshio Ota; Mai Hasumura; Shigeaki Takami; Masao Hirose; Akiyoshi Nishikawa
A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers.
Toxicologic pathology 2008;36(3):459-64.
2008: M Tasaki; Takashi Umemura; M Maeda; Y Ishii; T Okamura; Tohru Inoue; Yuichi Kuroiwa; Masao Hirose; Akiyoshi Nishikawa
Safety assessment of ellagic acid, a food additive, in a subchronic toxicity study using F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(3):1119-24.
2008: Keita Kanki; Takashi Umemura; Yasuki Kitamura; Yuji Ishii; Yuichi Kuroiwa; Yukio Kodama; Ken Itoh; Masayuki Yamamoto; Akiyoshi Nishikawa; Masao Hirose
A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate.
Toxicologic pathology 2008;36(2):353-61.
2008: Miwa Takahashi; Makoto Shibutani; Kaoru Inoue; Hitoshi Fujimoto; Masao Hirose; Akiyoshi Nishikawa
Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study.
The Journal of toxicological sciences 2008;33(1):11-24.
2008: Yuichi Kuroiwa; Toshiya Okamura; Yuji Ishii; Takashi Umemura; Masako Tasaki; Keita Kanki; Kunitoshi Mitsumori; Masao Hirose; Akiyoshi Nishikawa
Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation.
Cancer science 2008;99(1):7-13.
2008: Kaoru Inoue; Makoto Shibutani; Naoya Masutomi; Kazuhiro Toyoda; Hironori Takagi; Chikako Uneyama; Akiyoshi Nishikawa; Masao Hirose
A 13-week subchronic toxicity study of madder color in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(1):241-52.
2008: Miwa Takahashi; Makoto Shibutani; Yoshiko Sugita-Konishi; Maki Aihara; Kaoru Inoue; Gye-Hyeong Woo; Hitoshi Fujimoto; Masao Hirose
A 90-day subchronic toxicity study of nivalenol, a trichothecene mycotoxin, in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(1):125-35.
2007: Toshio Imai; Katsuhiro Fukuta; Mai Hasumura; Young-Man Cho; Yoshio Ota; Shigeaki Takami; Hitoshi Nakagama; Masao Hirose
Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
Carcinogenesis 2007;28(10):2199-206.
2007: Takashi Umemura; Yuichi Kuroiwa; Masako Tasaki; Toshiya Okamura; Yuji Ishii; Yukio Kodama; Takehiko Nohmi; Kunitoshi Mitsumori; Akiyoshi Nishikawa; Masao Hirose
Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice.
Mutation research 2007;633(1):46-54.
2007: Gye-Hyeong Woo; Makoto Shibutani; Keiko Kuroiwa; Kyoung-Youl Lee; Miwa Takahashi; Kaoru Inoue; Hitoshi Fujimoto; Masao Hirose
Lack of preventive effects of dietary fibers or chlorophyllin against acrylamide toxicity in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(8):1507-15.
2007: Yuichi Kuroiwa; Yuji Ishii; Takashi Umemura; Keita Kanki; Kunitoshi Mitsumori; Akiyoshi Nishikawa; Hiroyuki Nakazawa; Masao Hirose
Combined treatment with green tea catechins and sodium nitrite selectively promotes rat forestomach carcinogenesis after initiation with N-methyl-N'- nitro-N-nitrosoguanidine.
Cancer science 2007;98(7):949-57.
2007: Gye-Hyeong Woo; Makoto Shibutani; Kaoru Inoue; Hitoshi Fujimoto; Miwa Takahashi; Kyoung-Youl Lee; Masao Hirose
Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(7):1160-4.
2007: Toshio Imai; Mai Hasumura; Young-Man Cho; Jun-ichi Onose; Masao Hirose
Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats.
Cancer science 2007;98(3):294-8.
2007: Makoto Shibutani; Kyoung-Youl Lee; Katsuhide Igarashi; Gye-Hyeong Woo; Kaoru Inoue; Tetsuji Nishimura; Masao Hirose
Hypothalamus region-specific global gene expression profiling in early stages of central endocrine disruption in rat neonates injected with estradiol benzoate or flutamide.
Developmental neurobiology 2007;67(3):253-69.
2007: Gye-Hyeong Woo; Makoto Shibutani; Tsutomu Ichiki; Masao Hamamura; Kyoung-Youl Lee; Kaoru Inoue; Masao Hirose
A repeated 28-day oral dose toxicity study of nonylphenol in rats, based on the 'Enhanced OECD Test Guideline 407' for screening of endocrine-disrupting chemicals.
Archives of toxicology 2007;81(2):77-88.
2007: Mai Hasumura; Makoto Ueda; Jun-ichi Onose; Toshio Imai; Masao Hirose
Lack of a significant effect of arctiin on development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats.
Nutrition and cancer 2007;57(2):201-8.
2007: Yasuki Kitamura; Takashi Umemura; Keita Kanki; Yukio Kodama; Sachiko Kitamoto; Koichi Saito; Ken Itoh; Masayuki Yamamoto; Toshiaki Masegi; Akiyoshi Nishikawa; Masao Hirose
Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline.
Cancer science 2007;98(1):19-24.
2007: Yuichi Kuroiwa; Takashi Umemura; Akiyoshi Nishikawa; Keita Kanki; Yuji Ishii; Yukio Kodama; Ken-ichi Masumura; Takehiko Nohmi; Masao Hirose
Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice.
Archives of toxicology 2007;81(1):63-9.
2006: Young-Man Cho; Toshio Imai; Mai Hasumura; Masao Hirose
Lack of enhancement of susceptibility to mammary and thyroid carcinogenesis in rats exposed to DMBA and DHPN following prepubertal iodine deficiency.
Cancer science 2006;97(10):1031-6.
2006: Yuichi Kuroiwa; Akiyoshi Nishikawa; Yasuki Kitamura; Keita Kanki; Yuji Ishii; Takashi Umemura; Masao Hirose
Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters.
Cancer letters 2006;241(2):275-80.
2006: Takashi Umemura; Keita Kanki; Yuichi Kuroiwa; Yuji Ishii; Keita Okano; Takehiko Nohmi; Akiyoshi Nishikawa; Masao Hirose
In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate.
Cancer science 2006;97(9):829-35.
2006: Keiko Kuroiwa; Makoto Shibutani; Kaoru Inoue; Kyoung-Youl Lee; Gye-Hyeong Woo; Masao Hirose
Subchronic toxicity study of water pepper extract in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(8):1236-44.
2006: Toshio Imai; Jun-ichi Onose; Mai Hasumura; Tamotsu Takizawa; Masao Hirose
Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicology letters 2006;164(1):71-80.
2006: Y-M Cho; Hiroshi Onodera; Makoto Ueda; Toshio Imai; Masao Hirose
A 13-week subchronic toxicity study of dietary administered morin in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(6):891-7.
2006: Toru Tamura; Kunitoshi Mitsumori; Yukari Totsuka; Keiji Wakabayashi; Rie Kido; Hiroshi Kasai; Masahiro Nasu; Masao Hirose
Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid.
Toxicology 2006;222(3):213-24.
2006: Yasuki Kitamura; Takashi Umemura; Kazushi Okazaki; Keita Kanki; Takayoshi Imazawa; Toshiaki Masegi; Akiyoshi Nishikawa; Masao Hirose
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine.
International journal of cancer. Journal international du cancer 2006;118(10):2399-404.
2006: Yasuki Kitamura; Takashi Umemura; Keita Kanki; Yuji Ishii; Yuichi Kuroiwa; Toshiaki Masegi; Akiyoshi Nishikawa; Masao Hirose
Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis: results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer science 2006;97(5):368-73.
2006: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Lack of enhancing effects of sodium nitrite on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Cancer letters 2006;235(1):69-74.
2006: Kyoung-Youl Lee; Makoto Shibutani; Kaoru Inoue; Keiko Kuroiwa; Mami U; Gye-Hyeong Woo; Masao Hirose
Methacarn fixation--effects of tissue processing and storage conditions on detection of mRNAs and proteins in paraffin-embedded tissues.
Analytical biochemistry 2006;351(1):36-43.
2006: Kazushi Okazaki; Yuji Ishii; Yasuki Kitamura; Satoshi Maruyama; Takashi Umemura; Makoto Miyauchi; Megumi Yamagishi; Takayoshi Imazawa; Akiyoshi Nishikawa; Yoshihiro Yoshimura; Hiroyuki Nakazawa; Masao Hirose
Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage.
Cancer science 2006;97(3):175-82.
2006: Takashi Umemura; Yuichi Kuroiwa; Yasuki Kitamura; Yuji Ishii; Keita Kanki; Yukio Kodama; Ken Itoh; Masayuki Yamamoto; Akiyoshi Nishikawa; Masao Hirose
A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(1):111-9.
2006: Jun-ichi Onose; Toshio Imai; Mai Hasumura; Young-Man Cho; Masao Hirose
A new medium-term rat colon bioassay applying neoplastic lesions as endpoints for detection of carcinogenesis modifiers-validation with known modifiers.
Cancer letters 2006;232(2):272-8.
2006: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Akiyoshi Nishikawa; W Matsumoto; Masao Hirose
Lack of chemopreventive effects of alpha-eleostearic acid on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(2):271-7.
2006: Takashi Umemura; Yukio Kodama; Akiyoshi Nishikawa; Kyoji Hioki; Tatsuji Nomura; Keita Kanki; Yuichi Kuroiwa; Yuji Ishii; Yuji Kurokawa; Masao Hirose
Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model.
Cancer letters 2006;231(2):314-8.
2006: Hitoshi Fujimoto; Makoto Shibutani; Keiko Kuroiwa; Kaoru Inoue; Gye-Hyeong Woo; Mami U; Masao Hirose
A case report of a spontaneous gastrointestinal stromal tumor (GIST) occurring in a F344 rat.
Toxicologic pathology 2006;34(2):164-7.
2006: Tamotsu Takizawa; Toshio Imai; Makoto Ueda; Hiroshi Onodera; Masao Hirose
Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds.
Cancer science 2006;97(1):25-31.
2006: Akiyoshi Nishikawa; Kimie Sai; Kazushi Okazaki; Hwa-Young Son; Keita Kanki; Madoka Nakajima; Naohide Kinae; Takehiko Nohmi; James E Trosko; Tohru Inoue; Masao Hirose
MX, a by-product of water chlorination, lacks in vivo genotoxicity in gpt delta mice but inhibits gap junctional intercellular communication in rat WB cells.
Environmental and molecular mutagenesis 2006;47(1):48-55.
2006: Yuichi Kuroiwa; Akiyoshi Nishikawa; Takayoshi Imazawa; Yasuki Kitamura; Keita Kanki; Y Ishii; Takashi Umemura; Masao Hirose
A subchronic toxicity study of dunaliella carotene in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(1):138-45.
2006: Y Ota; Mai Hasumura; M Okamura; A Takahashi; Makoto Ueda; Hiroshi Onodera; Toshio Imai; Kunitoshi Mitsumori; Masao Hirose
Chronic toxicity and carcinogenicity of dietary administered ammonium sulfate in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(1):17-27.
2005: Toshio Imai; Young-Man Cho; Mai Hasumura; Masao Hirose
Enhancement by acrylamide of N-methyl-N-nitrosourea-induced rat mammary tumor development-possible application for a model to detect co-modifiers of carcinogenesis.
Cancer letters 2005;230(1):25-32.
2005: Hironori Takagi; Makoto Shibutani; Kyoung-Youl Lee; Naoya Masutomi; Haruka Fujita; Kaoru Inoue; Kunitoshi Mitsumori; Masao Hirose
Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring.
Toxicology and applied pharmacology 2005;208(2):127-36.
2005: Yuichi Kuroiwa; Akiyoshi Nishikawa; Takayoshi Imazawa; Yasuki Kitamura; Keita Kanki; Takashi Umemura; Masao Hirose
Lack of carcinogenicity of D-xylose given in the diet to F344 rats for two years.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(9):1399-404.
2005: Kyoung-Youl Lee; Makoto Shibutani; Keiko Kuroiwa; Hironori Takagi; Kaoru Inoue; Hiroshi Nishikawa; Tokutaro Miki; Masao Hirose
Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanate.
Archives of toxicology 2005;79(9):531-41.
2005: Akiyoshi Nishikawa; Takako Ikeda; Hwa-Young Son; Kazushi Okazaki; Takayoshi Imazawa; Takashi Umemura; Shuichi Kimura; Masao Hirose
Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(2):258-63.
2005: Mai Hasumura; Toshio Imai; Tamotsu Takizawa; Makoto Ueda; Jun-ichi Onose; Masao Hirose
Promotion of thyroid carcinogenesis by para-aminobenzoic acid in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicological sciences : an official journal of the Society of Toxicology 2005;86(1):61-7.
2005: Yuichi Kuroiwa; Akiyoshi Nishikawa; Takayoshi Imazawa; Keita Kanki; Yasuki Kitamura; Takashi Umemura; Masao Hirose
Lack of subchronic toxicity of an aqueous extract of Agaricus blazei Murrill in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(7):1047-53.
2005: Young-Man Cho; Toshio Imai; Mai Hasumura; Jun-ichi Onose; Makoto Ueda; Masao Hirose
Lack of prepubertal administration of ethinyl estradiol on susceptibility to multiple organ carcinogenesis in rats exposed to 7,12-dimethylbenz[a]anthracene and N-bis(2-hydroxypropyl)nitrosamine during adolescence.
Cancer letters 2005;223(1):37-46.
2005: Akiyoshi Nishikawa; Takayoshi Imazawa; Yuichi Kuroiwa; Yasuki Kitamura; Keita Kanki; Yuji Ishii; Takashi Umemura; Masao Hirose
Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment.
Toxicological sciences : an official journal of the Society of Toxicology 2005;84(2):243-8.
2005: Hironori Takagi; Makoto Shibutani; Chikako Uneyama; Kyoung-Youl Lee; Natsumi Kato; Kaoru Inoue; Masao Hirose
Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model.
Cancer letters 2005;219(2):147-53.
2005: Makoto Shibutani; Naoya Masutomi; Chikako Uneyama; Naoko Abe; Hironori Takagi; Kyoung-Youl Lee; Masao Hirose
Down-regulation of GAT-1 mRNA expression in the microdissected hypothalamic medial preoptic area of rat offspring exposed maternally to ethinylestradiol.
Toxicology 2005;208(1):35-48.
2005: Toshio Ichihara; Kayoko Miyashita; Mayumi Kawabe; Katsumi Imaida; Makoto Asamoto; Tadashi Ogiso; Seiko Tamano; Masao Hirose; Tomoyuki Shirai
Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.
The Journal of toxicological sciences 2005;30(1):1-6.
2005: Yasuki Kitamura; Akiyoshi Nishikawa; Hideaki Nakamura; Fumio Furukawa; Takayoshi Imazawa; Takashi Umemura; Koji Uchida; Masao Hirose
Effects of N-acetylcysteine, quercetin, and phytic acid on spontaneous hepatic and renal lesions in LEC rats.
Toxicologic pathology 2005;33(5):584-92.
2005: Toshio Imai; Mai Hasumura; Jun-ichi Onose; Makoto Ueda; Tamotsu Takizawa; Young-Man Cho; Masao Hirose
Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model: biological impact of capsular inflammation and reduced cyclooxygenase-2 expression.
Cancer science 2005;96(1):31-7.
2005: Makoto Ueda; Toshio Imai; Tamotsu Takizawa; Hiroshi Onodera; Kunitoshi Mitsumori; Takane Matsui; Masao Hirose
Possible enhancing effects of atrazine on growth of 7,12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats.
Cancer science 2005;96(1):19-25.
2005: Keita Kanki; Akiyoshi Nishikawa; Ken-ichi Masumura; Takashi Umemura; Takayoshi Imazawa; Yasuki Kitamura; Takehiko Nohmi; Masao Hirose
In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate.
Molecular carcinogenesis 2005;42(1):9-17.
2004: Kyoung-Youl Lee; Makoto Shibutani; Hironori Takagi; Natsumi Kato; Shu Takigami; Chikako Uneyama; Masao Hirose
Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation.
Toxicology 2004;203(1-3):221-38.
2004: Akiyoshi Nishikawa; Yukio Mori; In-Seon Lee; Takuji Tanaka; Masao Hirose
Cigarette smoking, metabolic activation and carcinogenesis.
Current drug metabolism 2004;5(5):363-73.
2004: Tamotsu Takizawa; Toshio Imai; Jun-ichi Onose; Makoto Ueda; Toru Tamura; Kunitoshi Mitsumori; Keisuke Izumi; Masao Hirose
Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;81(1):43-9.
2004: Natsumi Kato; Makoto Shibutani; Hironori Takagi; Chikako Uneyama; Kyoung-Youl Lee; Shu Takigami; Keisuke Mashima; Masao Hirose
Gene expression profile in the livers of rats orally administered ethinylestradiol for 28 days using a microarray technique.
Toxicology 2004;200(2-3):179-92.
2004: Hironori Takagi; Makoto Shibutani; Kyoung-Youl Lee; Hwi-Cheul Lee; Masugi Nishihara; Chikako Uneyama; Shu Takigami; Kunitoshi Mitsumori; Masao Hirose
Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats.
Reproductive toxicology (Elmsford, N.Y.) 2004;18(5):687-700.
2004: Hironori Takagi; Makoto Shibutani; Natsumi Kato; Haruka Fujita; Kyoung-Youl Lee; Shu Takigami; Kunitoshi Mitsumori; Masao Hirose
Microdissected region-specific gene expression analysis with methacarn-fixed, paraffin-embedded tissues by real-time RT-PCR.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(7):903-13.
2004: Akiyoshi Nishikawa; Fumio Furukawa; In-Seon Lee; Takuji Tanaka; Masao Hirose
Potent chemopreventive agents against pancreatic cancer.
Current cancer drug targets 2004;4(4):373-84.
2004: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Yasuki Kitamura; Keita Kanki; Kyong-Youl Lee; Takashi Umemura; Masao Hirose
Specificity of co-promoting effects of caffeine on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicologic pathology 2004;32(3):338-44.
2004: Takashi Umemura; Yasuki Kitamura; Keita Kanki; Satoshi Maruyama; Kazushi Okazaki; Takayoshi Imazawa; Tetsuji Nishimura; Ryuichi Hasegawa; Akiyoshi Nishikawa; Masao Hirose
Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate.
Cancer science 2004;95(5):393-8.
2004: Kyoung-Youl Lee; Makoto Shibutani; Hironori Takagi; Takuro Arimura; Shu Takigami; Chikako Uneyama; Natsumi Kato; Masao Hirose
Subchronic toxicity study of dietary N-acetylglucosamine in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(4):687-95.
2004: Naoya Masutomi; Makoto Shibutani; Hironori Takagi; Chikako Uneyama; Kyoung-Youl Lee; Masao Hirose
Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals.
Archives of toxicology 2004;78(4):232-40.
2004: Shinichiro Orita; Masao Hirose; Satoru Takahashi; Katsumi Imaida; Nobuyuki Ito; Koichi Shudo; Hajime Ohigashi; Akira Murakami; Tomoyuki Shirai
Modifying effects of 1'-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats.
Toxicologic pathology 2004;32(2):250-7.
2004: Toshio Imai; Jun-ichi Onose; Mai Hasumura; Makoto Ueda; Tamotsu Takizawa; Masao Hirose
Sequential analysis of development of invasive thyroid follicular cell carcinomas in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation.
Toxicologic pathology 2004;32(2):229-36.
2004: Mai Hasumura; Kazuo Yasuhara; Toru Tamura; Toshio Imai; Kunitoshi Mitsumori; Masao Hirose
Evaluation of the toxicity of enzymatically decomposed rutin with 13-weeks dietary administration to Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(3):439-44.
2004: Hironori Takagi; Makoto Shibutani; Naoya Masutomi; Chikako Uneyama; Noriyuki Takahashi; Kunitoshi Mitsumori; Masao Hirose
Lack of maternal dietary exposure effects of bisphenol A and nonylphenol during the critical period for brain sexual differentiation on the reproductive/endocrine systems in later life.
Archives of toxicology 2004;78(2):97-105.
2004: Naoya Masutomi; Makoto Shibutani; Hironori Takagi; Chikako Uneyama; Masao Hirose
Dietary influence on the impact of ethinylestradiol-induced alterations in the endocrine/reproductive system with perinatal maternal exposure.
Reproductive toxicology (Elmsford, N.Y.) 2004;18(1):23-33.
2004: Tamotsu Takizawa; Kunitoshi Mitsumori; Hisayoshi Takagi; M Nasu; Kazuo Yasuhara; Hiroshi Onodera; Toshio Imai; Masao Hirose
Sequential analysis of testicular lesions and serum hormone levels in rats treated with a Psoralea corylifolia extract.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2004;42(1):1-7.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Kyong- Youl Lee; Takayoshi Imazawa; Masao Hirose
Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(12):1811-6.
2003: Naoya Masutomi; Makoto Shibutani; Hironori Takagi; Chikako Uneyama; Noriyuki Takahashi; Masao Hirose
Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life.
Toxicology 2003;192(2-3):149-70.
2003: Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Akiyoshi Nishikawa; Toshiaki Masegi; Masao Hirose
Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl)nitrosamine in rats after initiation.
Cancer science 2003;94(11):948-52.
2003: Takayoshi Imazawa; Akiyoshi Nishikawa; Kazuhiro Toyoda; Fumio Furukawa; Masayuki Mitsui; Masao Hirose
Sequential alteration of apoptosis, p53 expression, and cell proliferation in the rat pancreas treated with 4-hydroxyaminoquinoline 1-oxide.
Toxicologic pathology 2003;31(6):625-31.
2003: Yasuki Kitamura; Akiyoshi Nishikawa; Fumio Furukawa; Hideaki Nakamura; Kazushi Okazaki; Takashi Umemura; Takayoshi Imazawa; Masao Hirose
A subchronic toxicity study of shea nut color in Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(11):1537-42.
2003: Yasuki Kitamura; Megumi Yamagishi; Kazushi Okazaki; Hwa-Young Son; Takayoshi Imazawa; Akiyoshi Nishikawa; Toshio Iwata; Yoshie Yamauchi; Masaaki Kasai; Kentaro Tsutsumi; Masao Hirose
Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.
Cancer letters 2003;200(2):133-9.
2003: Keita Kanki; Akiyoshi Nishikawa; Fumio Furukawa; Yasuki Kitamura; Takayoshi Imazawa; Takashi Umemura; Masao Hirose
A 13-week subchronic toxicity study of paprika color in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(10):1337-43.
2003: Kaoru Toyosawa; Kohji Tanaka; Toshio Imai; Kazuo Yasuhara; Takatoshi Koujitani; Masao Hirose; Kunitoshi Mitsumori
Mutation and overexpression of the transgene in ethylnitrosourea-induced tumors in mice carrying a human prototype c-Ha-ras gene.
Toxicologic pathology 2003;31(5):491-5.
2003: Jun-ichi Onose; Toshio Imai; Mai Hasumura; Makoto Ueda; Masao Hirose
Rapid induction of colorectal tumors in rats initiated with 1,2-dimethylhydrazine followed by dextran sodium sulfate treatment.
Cancer letters 2003;198(2):145-52.
2003: Jing Lei Cheng; Mitsuru Futakuchi; Kumiko Ogawa; Toshio Iwata; Masaaki Kasai; Shinkan Tokudome; Masao Hirose; Tomoyuki Shirai
Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats.
Cancer letters 2003;196(2):161-8.
2003: Keisuke Akagi; Masashi Sano; Kumiko Ogawa; Masao Hirose; Hideo Goshima; Tomoyuki Shirai
Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats.
Toxicologic pathology 2003;31(4):388-96.
2003: Takashi Umemura; Sachie Kai; Ryuichi Hasegawa; Keita Kanki; Yasuki Kitamura; Akiyoshi Nishikawa; Masao Hirose
Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamine-induced hepato- and cholangiocarcinogenesis in mice by green tea infusion.
Carcinogenesis 2003;24(6):1105-9.
2003: Tamotsu Takizawa; Kunitoshi Mitsumori; Toru Tamura; Masahiro Nasu; Makoto Ueda; Toshio Imai; Masao Hirose
Hepatocellular tumor induction in heterozygous p53-deficient CBA mice by a 26-week dietary administration of kojic acid.
Toxicological sciences : an official journal of the Society of Toxicology 2003;73(2):287-93.
2003: Fumio Furukawa; Akiyoshi Nishikawa; In-Seon Lee; Keita Kanki; Takashi Umemura; Kazushi Okazaki; Toshihiko Kawamori; Keiji Wakabayashi; Masao Hirose
A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
International journal of cancer. Journal international du cancer 2003;104(3):269-73.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Keita Kanki; Kazushi Okazaki; Yasuki Kitamura; Kyong-Youl Lee; Takashi Umemura; Masao Hirose
Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer science 2003;94(4):334-7.
2003: Satoshi Sugiura; Kumiko Ogawa; Masao Hirose; Fumitaka Takeshita; Makoto Asamoto; Tomoyuki Shirai
Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.
Carcinogenesis 2003;24(3):547-53.
2003: Megumi Yamagishi; Midori Natsume; Naomi Osakabe; Kazushi Okazaki; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Cancer letters 2003;191(1):49-57.
2003: Hwa-Young Son; Akiyoshi Nishikawa; Kazushi Okazaki; Keita Kanki; Megumi Yamagishi; Takayoshi Imazawa; Takashi Umemura; Masao Hirose
Prolonged effects of beta-estradiol 3-benzoate on thyroid tumorigenesis in gonadectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer letters 2003;190(1):21-9.
2003: Makoto Ueda; Naoko Niho; Toshio Imai; Makoto Shibutani; Kunitoshi Mitsumori; Takane Matsui; Masao Hirose
Lack of significant effects of genistein on the progression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats.
Nutrition and cancer 2003;47(2):141-7.
2003: Takashi Umemura; Yukio Kodama; Keita Kanki; Michael J Iatropoulos; Akiyoshi Nishikawa; Masao Hirose; Gary M Williams
Pentachlorophenol (but not phenobarbital) promotes intrahepatic biliary cysts induced by diethylnitrosamine to cholangio cystic neoplasms in B6C3F1 mice possibly due to oxidative stress.
Toxicologic pathology 2003;31(1):10-3.
2002: Masao Hirose; Tsuyoshi Yamaguchi; Yasumoto Mizoguchi; Keisuke Akagi; Mitsuru Futakuchi; Tomoyuki Shirai
Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses.
Cancer letters 2002;188(1-2):163-70.
2002: Hideaki Yada; Masao Hirose; Seiko Tamano; Mayumi Kawabe; Masashi Sano; Satoru Takahashi; Mitsuru Futakuchi; Tokutaro Miki; Tomoyuki Shirai
Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model.
Japanese journal of cancer research : Gann 2002;93(12):1299-307.
2002: Megumi Yamagishi; Midori Natsume; Naomi Osakabe; Hideaki Nakamura; Fumio Furukawa; Takayoshi Imazawa; Akiyoshi Nishikawa; Masao Hirose
Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats.
Cancer letters 2002;185(2):123-30.
2002: Shugo Suzuki; Satoru Takahashi; Makoto Asamoto; Shingo Inaguma; Tadashi Ogiso; Masao Hirose; Tomoyuki Shirai
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer.
Cancer letters 2002;185(1):39-45.
2002: Toshio Imai; Kazuo Yasuhara; H Matsui; S Maruyama; N Fujimoto; Kunitoshi Mitsumori; Masao Hirose
Iron lactate induction of pancreatic and endometrial proliferative lesions and a lack of increased tumors in a 104-week carcinogenicity study in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(10):1441-8.
2002: Kazushi Okazaki; Shuzo Okazaki; Hideaki Nakamura; Yasuki Kitamura; Kazuhisa Hatayama; Sachiko Wakabayashi; Toshiharu Tsuda; Tomoyoshi Katsumata; Akiyoshi Nishikawa; Masao Hirose
A repeated 28-day oral dose toxicity study of genistein in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals.
Archives of toxicology 2002;76(10):553-9.
2002: Chikako Uneyama; Makoto Shibutani; Naoya Masutomi; Hironori Takagi; Masao Hirose
Methacarn fixation for genomic DNA analysis in microdissected, paraffin-embedded tissue specimens.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002;50(9):1237-45.
2002: Takashi Umemura; Yukio Kodama; Kyoji Hioki; Tatsuji Nomura; Akiyoshi Nishikawa; Masao Hirose; Yuji Kurokawa
The mouse rasH2/BHT model as an in vivo rapid assay for lung carcinogens.
Japanese journal of cancer research : Gann 2002;93(8):861-6.
2002: Makoto Ueda; Hisayoshi Takagi; Hiroshi Onodera; Kazuo Yasuhara; Tamotsu Takizawa; Toshio Imai; Kunitoshi Mitsumori; Takane Matsui; Masao Hirose
Enhancing effects of beta-estradiol 3-benzoate but not methoxychlor on the promotion/progression stage of chemically-induced mammary carcinogenesis in ovariectomized rats.
Japanese journal of cancer research : Gann 2002;93(7):752-9.
2002: Ken-Ichiro Kasahara; Akiyoshi Nishikawa; Fumio Furukawa; S Ikezaki; Z Tanakamaru; In Seon Lee; Takayoshi Imazawa; Masao Hirose
A chronic toxicity study of josamycin in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(7):1017-22.
2002: Fumio Furukawa; Akiyoshi Nishikawa; Y Kitahori; Z Tanakamaru; Masao Hirose
Spontaneous development of aberrant crypt foci in F344 rats.
Journal of experimental & clinical cancer research : CR 2002;21(2):197-201.
2002: Makoto Shibutani; Noriyuki Takahashi; Tsuneo Kobayashi; Chikako Uneyama; Naoya Masutomi; Akiyoshi Nishikawa; Masao Hirose
Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay.
Carcinogenesis 2002;23(6):1047-55.
2002: Tamotsu Takizawa; Toshio Imai; Kunitoshi Mitsumori; Hisayoshi Takagi; Hiroshi Onodera; Kazuo Yasuhara; Makoto Ueda; Toru Tamura; Masao Hirose
Gonadal toxicity of an ethanol extract of Psoralea corylifolia in a rat 90-day repeated dose study.
The Journal of toxicological sciences 2002;27(2):97-105.
2002: Naoko Niho; Makoto Shibutani; Kazuhiro Toyoda; H Sato; Akihiko Hirose; K Imaida; Mika Takahashi; Y Hayashi; Masao Hirose
Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(5):715-22.
2002: Mitsuru Futakuchi; Jing Lei Cheng; Masao Hirose; Naoya Kimoto; Young Man Cho; Toshio Iwata; Masaaki Kasai; Shinkan Tokudome; Tomoyuki Shirai
Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Cancer letters 2002;178(2):131-9.
2002: Fumio Furukawa; Akiyoshi Nishikawa; Takeshi Chihara; Kan Shimpo; Hidehiko Beppu; Hiroshi Kuzuya; In Seon Lee; Masao Hirose
Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
Cancer letters 2002;178(2):117-22.
2002: Makoto Miyauchi; Hideaki Nakamura; Fumio Furukawa; Hwa-Young Son; Akiyoshi Nishikawa; Masao Hirose
Promoting effects of combined antioxidant and sodium nitrite treatment on forestomach carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer letters 2002;178(1):19-24.
2002: Hisayoshi Takagi; Kunitoshi Mitsumori; Hiroshi Onodera; Masahiro Nasu; Toru Tamura; Kazuo Yasuhara; Kiyoshi Takegawa; Masao Hirose
Improvement of a two-stage carcinogenesis model to detect modifying effects of endocrine disrupting chemicals on thyroid carcinogenesis in rats.
Cancer letters 2002;178(1):1-9.
2002: Hideaki Nakamura; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Makoto Miyauchi; Kazushi Okazaki; Takayoshi Imazawa; Koji Uchida; Masao Hirose
Enhancing effects of oltipraz on the development of spontaneous hepatic lesions in LEC rats.
Toxicologic pathology 2002;30(2):173-7.
2002: Mitsuru Futakuchi; Masao Hirose; Katsumi Imaida; Satoru Takahashi; Kumiko Ogawa; Makoto Asamoto; Tokutaro Miki; Tomoyuki Shirai
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.
Carcinogenesis 2002;23(2):283-7.
2002: Toshio Imai; Kazuo Yasuhara; Toru Tamura; Tamotsu Takizawa; Makoto Ueda; Masao Hirose; Kunitoshi Mitsumori
Inhibitory effects of cinnamaldehyde on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung carcinogenesis in rasH2 mice.
Cancer letters 2002;175(1):9-16.
2002: Kazushi Okazaki; Megumi Yamagishi; Hwa-Young Son; Takayoshi Imazawa; Fumio Furukawa; Hideaki Nakamura; Akiyoshi Nishikawa; Toshiaki Masegi; Masao Hirose
Simultaneous treatment with benzyl isothiocyanate, a strong bladder promoter, inhibits rat urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Nutrition and cancer 2002;42(2):211-6.
2002: Masao Hirose; Akiyoshi Nishikawa; Makoto Shibutani; Toshio Imai; Tomoyuki Shirai
Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats.
Environmental and molecular mutagenesis 2002;39(2-3):271-8.
2002: Kazushi Okazaki; Takayoshi Imazawa; Hideaki Nakamura; Fumio Furukawa; Akiyoshi Nishikawa; Masao Hirose
A repeated 28-day oral dose toxicity study of 17alpha-methyltestosterone in rats, based on the 'enhanced OECD Test Guideline 407' for screening the endocrine-disrupting chemicals.
Archives of toxicology 2002;75(11-12):635-42.
2002: Akiyoshi Nishikawa; Fumio Furukawa; Makoto Miyauchi; Hwa-Young Son; Kazushi Okazaki; Akihiro Koide; Yukio Mori; Masao Hirose
Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2.
Japanese journal of cancer research : Gann 2002;93(1):24-31.
2001: Naoya Masutomi; Kazuhiro Toyoda; Makoto Shibutani; Naoko Niho; Chikako Uneyama; Noriyuki Takahashi; Masao Hirose
Toxic effects of benzyl and allyl isothiocyanates and benzyl-isoform specific metabolites in the urinary bladder after a single intravesical application to rats.
Toxicologic pathology 2001;29(6):617-22.
2001: Naoko Niho; Makoto Shibutani; Toru Tamura; Kazuhiro Toyoda; Chikako Uneyama; Noriyuki Takahashi; Masao Hirose
Subchronic toxicity study of gallic acid by oral administration in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(11):1063-70.
2001: Takatoshi Koujitani; Kazuo Yasuhara; Toru Tamura; Hiroshi Onodera; Hisayoshi Takagi; Tamotsu Takizawa; Masao Hirose; Y Hayashi; Kunitoshi Mitsumori
Lack of modifying effects of eugenol on development of lung proliferative lesions induced by urethane in transgenic mice carrying the human prototype c-Ha-ras gene.
The Journal of toxicological sciences 2001;26(3):129-39.
2001: Hideaki Nakamura; Fumio Furukawa; Akiyoshi Nishikawa; M Miyauchi; Hwa-Young Son; Takayoshi Imazawa; Masao Hirose
Oral toxicity of a tocotrienol preparation in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2001;39(8):799-805.
2001: Masao Hirose; Toru Hoshiya; Yasumoto Mizoguchi; A Nakamura; Keisuke Akagi; Tomoyuki Shirai
Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2'-dihydroxy-di-n-propylnitrosamine in male F344 rats.
Cancer letters 2001;168(1):23-9.
2001: Naoya Kimoto; Masao Hirose; Mitsuru Futakuchi; Toshio Iwata; Masaaki Kasai; Tomoyuki Shirai
Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats.
Cancer letters 2001;168(1):15-21.
2001: T Shoda; Kazuo Yasuhara; M Moriyasu; T Takahashi; Chikako Uneyama; Masao Hirose; Kunitoshi Mitsumori
Testicular toxicity of nitrofurazone causing germ cell apoptosis in rats.
Archives of toxicology 2001;75(5):297-305.
2001: Takayoshi Imazawa; Akiyoshi Nishikawa; Makoto Shibutani; H Ogasawara; Fumio Furukawa; T Ikeda; K Suda; Masao Hirose
Induction of pancreatic islet cell tumors in rats by repeated intravenous administration of 4-hydroxyaminoquinoline 1-oxide.
Toxicologic pathology 2001;29(3):320-7.
2001: Takatoshi Koujitani; Kazuo Yasuhara; Kaoru Toyosawa; A Shimada; Hiroshi Onodera; Hisayoshi Takagi; Toru Tamura; Masao Hirose; Kunitoshi Mitsumori
Immunohistochemical and ultrastructural studies of 2,6-dimethylaniline-induced nasal proliferative lesions in a rat two-stage nasal carcinogenesis model initiated with N-bis(2-hydroxypropyl)nitrosamine.
Toxicologic pathology 2001;29(3):300-7.
2001: Toru Tamura; Kunitoshi Mitsumori; Hiroshi Onodera; N Fujimoto; Kazuo Yasuhara; Kiyoshi Takegawa; Hisayoshi Takagi; Masao Hirose
Dose-threshold for thyroid tumor-promoting effects of orally administered kojic acid in rats after initiation with N-bis(2-hydroxypropyl) nitrosamine.
The Journal of toxicological sciences 2001;26(2):85-94.
2001: Takako Ikeda; Akiyoshi Nishikawa; Hwa-Young Son; Hideaki Nakamura; Makoto Miyauchi; Takayoshi Imazawa; Shuichi Kimura; Masao Hirose
Synergistic effects of high-dose soybean intake with iodine deficiency, but not sulfadimethoxine or phenobarbital, on rat thyroid proliferation.
Japanese journal of cancer research : Gann 2001;92(4):390-5.
2001: Kazuo Yasuhara; Takatoshi Koujitani; Kiyoshi Takegawa; Masahiro Nasu; Hiroshi Onodera; Hisayoshi Takagi; Masao Hirose; Kunitoshi Mitsumori
Promoting effects of xylazine on development of thyroid tumors in rats initiated with N-bis(2-hydroxypropyl)nitrosamine and the mechanism of action.
Carcinogenesis 2001;22(4):613-8.
2001: A Hagiwara; Y Takesada; Harunari Tanaka; Seiko Tamano; Masao Hirose; N Ito; Tomoyuki Shirai
Dose-dependent induction of glandular stomach preneoplastic and neoplastic lesions in male F344 rats treated with catechol chronically.
Toxicologic pathology 2001;29(2):180-6.
2001: Akiyoshi Nishikawa; Takayoshi Suzuki; Ken-ichi Masumura; Fumio Furukawa; Makoto Miyauchi; Hideaki Nakamura; Hwa-Young Son; Takehiko Nohmi; Makoto Hayashi; Masao Hirose
Reporter gene transgenic mice as a tool for analyzing the molecular mechanisms underlying experimental carcinogenesis.
Journal of experimental & clinical cancer research : CR 2001;20(1):111-5.
2001: Hwa-Young Son; Akiyoshi Nishikawa; Takako Ikeda; Takayoshi Imazawa; Shuichi Kimura; Masao Hirose
Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet.
Japanese journal of cancer research : Gann 2001;92(2):103-8.
2001: Kumiko Ogawa; Masao Hirose; S Sugiura; L Cui; Katsumi Imaida; Tadashi Ogiso; Tomoyuki Shirai
Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis.
Nutrition and cancer 2001;40(2):134-9.
2000: Hwa-Young Son; Akiyoshi Nishikawa; Fumio Furukawa; In Seon Lee; Takako Ikeda; Makoto Miyauchi; Hideaki Nakamura; Masao Hirose
Modifying effects of 4-phenylbutyl isothiocyanate on N-nitrosobis(2-oxopropyl)amine-induced tumorigenesis in hamsters.
Cancer letters 2000;160(2):141-7.
2000: Kunitoshi Mitsumori; T Shimo; Hiroshi Onodera; Hisayoshi Takagi; Kazuo Yasuhara; Toru Tamura; Y Aoki; O Nagata; Masao Hirose
Modifying effects of ethinylestradiol but not methoxychlor on N-ethyl-N-nitrosourea-induced uterine carcinogenesis in heterozygous p53-deficient CBA mice.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(1):43-9.
2000: Fumio Furukawa; Akiyoshi Nishikawa; Hideaki Nakamura; Makoto Miyauchi; H Son; Masao Hirose
Effects of octreotide, a somatostatin analogue, on initiation of pancreatic carcinogenesis in hamsters with N-nitrosobis(2-oxopropyl)amine.
Cancer letters 2000;159(1):43-8.
2000: Hwa-Young Son; Akiyoshi Nishikawa; Takako Ikeda; Fumio Furukawa; Masao Hirose
Lack of modification by environmental estrogenic compounds of thyroid carcinogenesis in ovariectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Japanese journal of cancer research : Gann 2000;91(10):966-72.
2000: Hideaki Nakamura; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Makoto Miyauchi; Hwa-Young Son; Masao Hirose
Inhibitory effects of protocatechuic acid on the post-initiation phase of hamster pancreatic carcinogenesis induced by N-nitrosobis(2-oxopropyl)amine.
Anticancer research 2000;20(5B):3423-7.
2000: Kiyoshi Takegawa; Kunitoshi Mitsumori; Kazuo Yasuhara; M Moriyasu; M Sakamori; Hiroshi Onodera; Masao Hirose; Tatsuji Nomura
A mechanistic study of ovarian carcinogenesis induced by nitrofurazone using rasH2 mice.
Toxicologic pathology 2000;28(5):649-55.
2000: Hwa-Young Son; Akiyoshi Nishikawa; Takako Ikeda; Hideaki Nakamura; Makoto Miyauchi; Takayoshi Imazawa; Fumio Furukawa; Masao Hirose
Lack of modifying effects of environmental estrogenic compounds on the development of thyroid proliferative lesions in male rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN).
Japanese journal of cancer research : Gann 2000;91(9):899-905.
2000: Kiyoshi Takegawa; Kunitoshi Mitsumori; Hiroshi Onodera; T Shimo; K Kitaura; Kazuo Yasuhara; Masao Hirose; Mika Takahashi
Studies on the carcinogenicity of potassium iodide in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(9):773-81.
2000: Masao Hirose; Tsuyoshi Yamaguchi; C Lin; Naoya Kimoto; Mitsuru Futakuchi; T Kono; S Nishibe; Tomoyuki Shirai
Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats.
Cancer letters 2000;155(1):79-88.
2000: Takatoshi Koujitani; Kazuo Yasuhara; T Ikeda; T Imazawa; Toru Tamura; Kaoru Toyosawa; A Shimada; Masao Hirose; Kunitoshi Mitsumori
Sequential observation of 2,6-dimethylaniline-induced nasal lesions in a rat two-stage nasal carcinogenesis model after initiation with N-bis(2-hydroxypropyl) nitrosamine.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2000;62(7):751-6.
2000: T Shoda; Kunitoshi Mitsumori; Hiroshi Onodera; Kazuhiro Toyoda; Chikako Uneyama; K Takada; Masao Hirose
Liver tumor-promoting effect of beta-naphthoflavone, a strong CYP 1A1/2 inducer, and the relationship between CYP 1A1/2 induction and Cx32 decrease in its hepatocarcinogenesis in the rat.
Toxicologic pathology 2000;28(4):540-7.
2000: Takayoshi Imazawa; Akiyoshi Nishikawa; A Todate; Fumio Furukawa; Hiroshi Onodera; Kunitoshi Mitsumori; Masao Hirose; Y Hayashi
Dual effects of prolonged ACTH stimulation on 4-hydroxyaminoquinoline 1-oxide-induced adrenocortical lesions in rats.
Toxicologic pathology 2000;28(4):535-9.
2000: Fumio Furukawa; Akiyoshi Nishikawa; Makoto Miyauchi; Hideaki Nakamura; Hwa-Young Son; Megumi Yamagishi; Masao Hirose
Concurrent administration of fish meal and sodium nitrite does not promote renal carcinogenesis in rats after initiation with N-ethyl-N-hydroxyethylnitrosamine.
Cancer letters 2000;154(1):45-51.
2000: Hwa-Young Son; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Makoto Miyauchi; Hideaki Nakamura; Takako Ikeda; Masao Hirose
Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters.
Cancer letters 2000;153(1-2):211-8.
2000: Kazuhiro Toyoda; Makoto Shibutani; T Tamura; Takatoshi Koujitani; Chikako Uneyama; Masao Hirose
Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the 'Enhanced OECD Test Guideline 407' for screening for endocrine-disrupting chemicals.
Archives of toxicology 2000;74(3):127-32.
2000: Kazuo Yasuhara; H Kobayashi; Y Shimamura; Takatoshi Koujitani; Hiroshi Onodera; Hisayoshi Takagi; Masao Hirose; Kunitoshi Mitsumori
Toxicity and blood concentrations of xylazine and its metabolite, 2,6-dimethylaniline, in rats after single or continuous oral administrations.
The Journal of toxicological sciences 2000;25(2):105-13.
2000: Makoto Miyauchi; Akiyoshi Nishikawa; Fumio Furukawa; Hideaki Nakamura; Hwa-Young Son; A Murakami; K Koshimizu; H Ohigashi; Masao Hirose
Inhibitory effects of 1'-acetoxychavicol acetate on N-Nitrosobis(2-oxopropyl)-amine-induced initiation of cholangiocarcinogenesis in Syrian hamsters.
Japanese journal of cancer research : Gann 2000;91(5):477-81.
2000: Kunitoshi Mitsumori; Hiroshi Onodera; T Shimo; Kazuo Yasuhara; Hisayoshi Takagi; Takatoshi Koujitani; Masao Hirose; Chika Maruyama; S Wakana
Rapid induction of uterine tumors with p53 point mutations in heterozygous p53-deficient CBA mice given a single intraperitoneal administration of N-ethyl-N-nitrosourea.
Carcinogenesis 2000;21(5):1039-42.
2000: Takatoshi Koujitani; Kazuo Yasuhara; T Usui; Tatsuji Nomura; Hiroshi Onodera; Hisayoshi Takagi; Masao Hirose; Kunitoshi Mitsumori
Lack of susceptibility of transgenic mice carrying the human c-Ha-ras proto-oncogene (rasH2 mice) to phenolphthalein in a 6-month carcinogenicity study.
Cancer letters 2000;152(2):211-6.
2000: Fumio Furukawa; Akiyoshi Nishikawa; In Seon Lee; Hwa-Young Son; Hideaki Nakamura; Makoto Miyauchi; Mika Takahashi; Masao Hirose
Inhibition by methionine of pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl) amine.
Cancer letters 2000;152(2):163-7.
2000: Takako Ikeda; Akiyoshi Nishikawa; Takayoshi Imazawa; Shuichi Kimura; Masao Hirose
Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia.
Carcinogenesis 2000;21(4):707-13.
2000: Takayoshi Imazawa; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Takako Ikeda; Mika Takahashi; Masao Hirose
Lack of carcinogenicity of gardenia blue colour given chronically in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(4):313-8.
2000: Fumio Furukawa; Akiyoshi Nishikawa; Hajimu Ishiwata; Mika Takahashi; Y Hayashi; Masao Hirose
Renal carcinogenicity of concurrently administered fish meal and sodium nitrite in F344 rats.
Japanese journal of cancer research : Gann 2000;91(2):139-47.
2000: Kazuhiro Toyoda; Makoto Shibutani; H Sato; Chikako Uneyama; Mika Takahashi; Y Hayashi; Masao Hirose
Lack of carcinogenicity and increased survival in F344 rats treated with 5-fluorouracil for two years.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(2-3):187-93.
2000: Makoto Shibutani; Chikako Uneyama; K Miyazaki; K Toyoda; Masao Hirose
Methacarn fixation: a novel tool for analysis of gene expressions in paraffin-embedded tissue specimens.
Laboratory investigation; a journal of technical methods and pathology 2000;80(2):199-208.
2000: Takayoshi Imazawa; Kunitoshi Mitsumori; S Kitajima; Hiroshi Onodera; Toru Tamura; Mika Takahashi; Masao Hirose
Time course of ultrastructural changes and immunoelectron microscopic localization of neurocalcin in motor endplates of the lumbrical muscles of rats given a single administration of 2,5-di(tert-butyl)-1,4-hydroquinone.
Acta neuropathologica 2000;99(2):109-16.
2000: Naoya Masutomi; Makoto Shibutani; Kazuhiro Toyoda; Naoko Niho; Chikako Uneyama; Masao Hirose
[A 90-day repeated dose toxicity study of madder color in F344 rats: a preliminary study for chronic toxicity and carcinogenicity studies].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2000;(118):55-62.
2000: Mayumi Kawabe; C Lin; Naoya Kimoto; Masashi Sano; Masao Hirose; Tomoyuki Shirai
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
Nutrition and cancer 2000;37(2):179-86.
2000: Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; S Ikezaki; T Itoh; Takayoshi Suzuki; K Uchida; M Kurihara; Makoto Hayashi; Naoki Miyata; Masao Hirose
Trans-4-hydroxy-2-nonenal, an aldehydic lipid peroxidation product, lacks genotoxicity in lacI transgenic mice.
Cancer letters 2000;148(1):81-6.
1999: Naoya Kimoto; Masao Hirose; Mayumi Kawabe; T Satoh; H Miyataka; Tomoyuki Shirai
Post-initiation effects of a super critical extract of propolis in a rat two-stage carcinogenesis model in female F344 rats.
Cancer letters 1999;147(1-2):221-7.
1999: Mitsuru Futakuchi; Masao Hirose; Tadashi Ogiso; Koji Kato; Masashi Sano; Kumiko Ogawa; Tomoyuki Shirai
Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model.
Japanese journal of cancer research : Gann 1999;90(11):1196-202.
1999: Masao Hirose; S Fukushima; K Imaida; N Ito; Tomoyuki Shirai
Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis.
Anticancer research 1999;19(5A):3665-70.
1999: T Shoda; Kunitoshi Mitsumori; Hiroshi Onodera; Kazuhiro Toyoda; Chikako Uneyama; Takayoshi Imazawa; Masao Hirose
The relationship between decrease in Cx32 and induction of P450 isozymes in the early phase of clofibrate hepatocarcinogenesis in the rat.
Archives of toxicology 1999;73(7):373-80.
1999: Masao Hirose; Satoru Takahashi; Kumiko Ogawa; Mitsuru Futakuchi; Tomoyuki Shirai
Phenolics: blocking agents for heterocyclic amine-induced carcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(9-10):985-92.
1999: T Shoda; Hiroshi Onodera; M Takeda; Chikako Uneyama; Takayoshi Imazawa; Kiyoshi Takegawa; Kazuo Yasuhara; T Watanabe; Masao Hirose; Kunitoshi Mitsumori
Liver tumor promoting effects of fenbendazole in rats.
Toxicologic pathology 1999;27(5):553-62.
1999: Masao Hirose; S Takahashi; K Ogawa; Mitsuru Futakuchi; Tomoyuki Shirai; Makoto Shibutani; Chikako Uneyama; Kazuhiro Toyoda; H Iwata
Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats.
Cancer letters 1999;143(2):173-8.
1999: Toru Tamura; Makoto Shibutani; Kazuhiro Toyoda; T Shoda; K Takada; Chikako Uneyama; Mika Takahashi; Masao Hirose
Tumor-promoting activities of hydroquinone and 1,1-dimethylhydrazine after initiation of newborn mice with 1-methyl-1-nitrosourea.
Cancer letters 1999;143(1):71-80.
1999: Takatoshi Koujitani; Kazuo Yasuhara; H Kobayashi; A Shimada; Hiroshi Onodera; Hisayoshi Takagi; Masao Hirose; Kunitoshi Mitsumori
Tumor-promoting activity of 2,6-dimethylaniline in a two-stage nasal carcinogenesis model in N-bis(2-hydroxypropyl)nitrosamine-treated rats.
Cancer letters 1999;142(2):161-71.
1999: Toru Tamura; Kunitoshi Mitsumori; Hiroshi Onodera; Mika Takahashi; T Funakoshi; Kazuo Yasuhara; Kiyoshi Takegawa; Hisayoshi Takagi; Masao Hirose
Time course observation of thyroid proliferative lesions and serum levels of related hormones in rats treated with kojic acid after DHPN initiation.
The Journal of toxicological sciences 1999;24(3):145-55.
1999: Makoto Miyauchi; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Hideaki Nakamura; Mika Takahashi; Masao Hirose
Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay.
Cancer letters 1999;142(1):75-81.
1999: Masao Hirose; K Hakoi; Satoru Takahashi; Toru Hoshiya; Keisuke Akagi; C Lin; K Saito; H Kaneko; Tomoyuki Shirai
Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats.
Toxicologic pathology 1999;27(4):448-55.
1999: Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Z Tanakamaru; Makoto Miyauchi; Hideaki Nakamura; Takako Ikeda; Takayoshi Imazawa; Masao Hirose
Failure of phenethyl isothiocyanate to inhibit hamster tumorigenesis induced by N-nitrosobis(2-oxopropyl)amine when given during the post-initiation phase.
Cancer letters 1999;141(1-2):109-15.
1999: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; Z Tanakamaru; Hideaki Nakamura; H Mori; Masao Hirose
Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats.
The Journal of toxicological sciences 1999;24(2):133-9.
1999: Akiyoshi Nishikawa; Fumio Furukawa; In Seon Lee; Ken-Ichiro Kasahara; Z Tanakamaru; Hideaki Nakamura; Makoto Miyauchi; Naohide Kinae; Masao Hirose
Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer research 1999;59(9):2045-9.
1999: A Hagiwara; P Boonyaphiphat; Harunari Tanaka; Mayumi Kawabe; Seiko Tamano; H Kaneko; M Matsui; Masao Hirose; N Ito; Tomoyuki Shirai
Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344 rats.
Japanese journal of cancer research : Gann 1999;90(4):399-405.
1999: Fumio Furukawa; Akiyoshi Nishikawa; Ken-Ichiro Kasahara; In Seon Lee; K Wakabayashi; Mika Takahashi; Masao Hirose
Inhibition by beta-carotene of upper respiratory tumorigenesis in hamsters receiving diethylnitrosamine followed by cigarette smoke exposure.
Japanese journal of cancer research : Gann 1999;90(2):154-61.
1999: Naoko Niho; Toru Tamura; Kazuhiro Toyoda; Chikako Uneyama; Makoto Shibutani; Masao Hirose
[A 13-week subchronic toxicity study of chitin in F344 rats].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 1999;(117):129-34.
1999: Tomoyuki Shirai; Masao Hirose; Nobuyuki Ito
Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals.
IARC scientific publications 1999;(146):251-72.
1998: Nobuyuki Ito; Katsumi Imaida; Masao Hirose; Tomoyuki Shirai
Medium-term bioassays for carcinogenicity of chemical mixtures.
Environmental health perspectives 1998;106 Suppl 6():1331-6.
1998: Satoru Takahashi; Seiko Tamano; Masao Hirose; Naoya Kimoto; Y Ikeda; M Sakakibara; M Tada; F F Kadlubar; N Ito; Tomoyuki Shirai
Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): detection in paraffin-embedded sections and tissue distribution.
Cancer research 1998;58(19):4307-13.
1998: Masao Hirose; Tsuyoshi Yamaguchi; Naoya Kimoto; Kumiko Ogawa; Mitsuru Futakuchi; Masashi Sano; Tomoyuki Shirai
Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats.
International journal of cancer. Journal international du cancer 1998;77(5):773-7.
1998: Kumiko Ogawa; Mitsuru Futakuchi; Masao Hirose; P Boonyaphiphat; Yasumoto Mizoguchi; Tokutaro Miki; Tomoyuki Shirai
Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model.
International journal of cancer. Journal international du cancer 1998;76(6):851-6.
1998: Masao Hirose; T Ito; Satoru Takahashi; M Ozaki; Tadashi Ogiso; Y Nihro; Tokutaro Miki; Tomoyuki Shirai
Prevention by synthetic phenolic antioxidants of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)- or activated MeIQx-induced mutagenesis and MeIQx-induced rat hepatocarcinogenesis, and role of antioxidant activity in the prevention of carcinogenesis.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(3):233-41.
1998: Yasumoto Mizoguchi; Masao Hirose; Tsuyoshi Yamaguchi; P Boonyaphiphat; Tokutaro Miki; Tomoyuki Shirai
Dose dependence of 1-O-hexyl-2,3,5-trimethylhydroquinone promotion of forestomach carcinogenesis in rats pretreated with N-ethylnitrosourethane.
Japanese journal of cancer research : Gann 1998;89(5):475-80.
1998: Mitsuru Futakuchi; Masao Hirose; Tokutaro Miki; Harunari Tanaka; M Ozaki; Tomoyuki Shirai
Inhibition of DMBA-initiated rat mammary tumour development by 1-O-hexyl-2,3,5-trimethylhydroquinone, phenylethyl isothiocyanate, and novel synthetic ascorbic acid derivatives.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(2):153-9.
1998: Seiko Tamano; Masao Hirose; Harunari Tanaka; A Hagiwara; Tomoyuki Shirai
Variation in susceptibility to the induction of forestomach tumours by butylated hydroxyanisole among rats of different strains.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(4):299-304.
1998: T Kato; Masao Hirose; Satoru Takahashi; R Hasegawa; T Kohno; S Nishibe; Koji Kato; Tomoyuki Shirai
Effects of the lignan, arctiin, on 17-beta ethinyl estradiol promotion of preneoplastic liver cell foci development in rats.
Anticancer research 1998;18(2A):1053-7.
1998: Satoru Takahashi; Masao Hirose; Seiko Tamano; Masakazu Ozaki; Shinichiro Orita; T Ito; M Takeuchi; H Ochi; S Fukada; H Kasai; Tomoyuki Shirai
Immunohistochemical detection of 8-hydroxy-2'-deoxyguanosine in paraffin-embedded sections of rat liver after carbon tetrachloride treatment.
Toxicologic pathology 1998;26(2):247-52.
1998: Masao Hirose; Mitsuru Futakuchi; Harunari Tanaka; Shinichiro Orita; T Ito; Tokutaro Miki; Tomoyuki Shirai
Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(1):61-7.
1998: S Wada; Masao Hirose; Y Shichino; K Ozaki; Toru Hoshiya; Koji Kato; Tomoyuki Shirai
Effects of catechol, sodium chloride and ethanol either alone or in combination on gastric carcinogenesis in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer letters 1998;123(2):127-34.
1998: Masao Hirose; Y Takesada; Harunari Tanaka; Seiko Tamano; T Kato; Tomoyuki Shirai
Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model.
Carcinogenesis 1998;19(1):207-12.
1997: Masao Hirose; Tomoyuki Shirai; M S Lee; C Y Wang; C M King
Carcinogenecity of the N-acyl derivatives of N-hydroxy-trans-4-aminostilbene in CD rats.
Chemico-biological interactions 1997;106(2):123-32.
1997: Harunari Tanaka; Masao Hirose; Mayumi Kawabe; Masashi Sano; Y Takesada; A Hagiwara; Tomoyuki Shirai
Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats.
Cancer letters 1997;116(1):47-52.
1997: Nobuyuki Ito; R Hasegawa; Katsumi Imaida; Seiko Tamano; A Hagiwara; Masao Hirose; Tomoyuki Shirai
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
Mutation research 1997;376(1-2):107-14.
1997: K Takaba; Masao Hirose; Y Yoshida; J Kimura; Nobuyuki Ito; Tomoyuki Shirai
Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model.
Cancer letters 1997;113(1-2):39-46.
1997: Masao Hirose; Yasumoto Mizoguchi; M Yaono; Harunari Tanaka; Tsuyoshi Yamaguchi; Tomoyuki Shirai
Effects of green tea catechins on the progression or late promotion stage of mammary gland carcinogenesis in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene.
Cancer letters 1997;112(2):141-7.
1997: Tomoyuki Shirai; M Sano; Seiko Tamano; Satoru Takahashi; Masao Hirose; Mitsuru Futakuchi; R Hasegawa; Katsumi Imaida; K Matsumoto; K Wakabayashi; T Sugimura; N Ito
The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.
Cancer research 1997;57(2):195-8.
1996: R Hasegawa; T Kato; Masao Hirose; Satoru Takahashi; Tomoyuki Shirai; Nobuyuki Ito
Enhancement of hepatocarcinogenesis by combined administration of food-derived heterocyclic amines at low doses in the rat.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(11-12):1097-101.
1996: Katsumi Imaida; A Hagiwara; H Yada; T Masui; R Hasegawa; Masao Hirose; T Sugimura; Nobuyuki Ito; Tomoyuki Shirai
Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.
Japanese journal of cancer research : Gann 1996;87(11):1116-20.
1996: Mitsuru Futakuchi; W Lijinsky; R Hasegawa; Masao Hirose; Nobuyuki Ito; Tomoyuki Shirai
Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat.
Cancer letters 1996;106(2):263-9.
1996: J Kimura; Satoru Takahashi; Tadashi Ogiso; Y Yoshida; Keisuke Akagi; R Hasegawa; M Kurata; Masao Hirose; Tomoyuki Shirai
Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model.
Japanese journal of cancer research : Gann 1996;87(6):589-94.
1996: A Hagiwara; E Miyata; Seiko Tamano; M A Shibata; S Sugiura; M Inoue; Masao Hirose
Non-carcinogenicity of 2,2'--(4-aminophenyl)imino-bisethanol sulfate in a long-term feeding study in Fischer 344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(6):537-46.
1996: Harunari Tanaka; R Hasegawa; Y Takesada; Tadashi Ogiso; Masao Hirose; Tomoyuki Shirai
Effects of carbamate insecticides in a rat medium-term bioassay for hepatocarcinogens.
Journal of toxicology and environmental health 1996;47(5):493-8.
1996: Nobuyuki Ito; R Hasegawa; Katsumi Imaida; Masao Hirose; Tomoyuki Shirai
Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(2-3):113-9.
1996: T Kato; R Hasegawa; D Nakae; Masao Hirose; M Yaono; L Cui; Y Kobayashi; Y Konishi; Nobuyuki Ito; Tomoyuki Shirai
Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
Japanese journal of cancer research : Gann 1996;87(2):127-33.
1996: A Hagiwara; Y Kokubo; Y Takesada; Harunari Tanaka; Seiko Tamano; Masao Hirose; Tomoyuki Shirai; Nobuyuki Ito
Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats.
Teratogenesis, carcinogenesis, and mutagenesis 1996;16(6):317-25.
1995: Masao Hirose; R Hasegawa; J Kimura; Keisuke Akagi; Y Yoshida; Harunari Tanaka; Tokutaro Miki; T Satoh; K Wakabayashi; Nobuyuki Ito
Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Carcinogenesis 1995;16(12):3049-55.
1995: Nobuyuki Ito; A Hagiwara; Seiko Tamano; R Hasegawa; Katsumi Imaida; Masao Hirose; Tomoyuki Shirai
Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats.
Toxicology letters 1995;82-83():513-20.
1995: Nobuyuki Ito; R Hasegawa; Katsumi Imaida; Masao Hirose; Makoto Asamoto; Tomoyuki Shirai
Concepts in multistage carcinogenesis.
Critical reviews in oncology/hematology 1995;21(1-3):105-133.
1995: M Shibata; R Hasegawa; Katsumi Imaida; A Hagiwara; Kumiko Ogawa; Masao Hirose; Nobuyuki Ito; Tomoyuki Shirai
Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.
Cancer research 1995;55(21):4870-4.
1995: R Hasegawa; Masao Hirose; T Kato; A Hagiwara; P Boonyaphiphat; M Nagao; Nobuyuki Ito; Tomoyuki Shirai
Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats.
Carcinogenesis 1995;16(9):2243-6.
1995: Masao Hirose; S Iwata; E Ito; Y Nihro; Satoru Takahashi; Yasumoto Mizoguchi; Tokutaro Miki; T Satoh; Nobuyuki Ito; Tomoyuki Shirai
Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole (Glu-p-1).
Carcinogenesis 1995;16(9):2227-32.
1995: Keisuke Akagi; Masao Hirose; Toru Hoshiya; Yasumoto Mizoguchi; Nobuyuki Ito; Tomoyuki Shirai
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Cancer letters 1995;94(1):113-21.
1995: Tomoyuki Shirai; Seiko Tamano; Masashi Sano; Katsumi Imaida; A Hagiwara; Mitsuru Futakuchi; Satoru Takahashi; Masao Hirose
Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2'-dimethyl-4-aminobiphenyl: dose-dependent induction of invasive carcinomas.
Japanese journal of cancer research : Gann 1995;86(7):645-8.
1995: T Masui; Tomoyuki Shirai; Katsumi Imaida; Masao Hirose; Mitsuru Futakuchi; M Tatematsu; Nobuyuki Ito
Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2'-dimethyl-4-aminobiphenyl.
Molecular carcinogenesis 1995;13(1):21-6.
1995: Tomoyuki Shirai; M Shibata; Satoru Takahashi; Y Tagawa; Katsumi Imaida; Masao Hirose
Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated.
Carcinogenesis 1995;16(3):501-5.
1995: Harunari Tanaka; Masao Hirose; A Hagiwara; Katsumi Imaida; Tomoyuki Shirai; Nobuyuki Ito
Rat strain differences in catechol carcinogenicity to the stomach.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(2):93-8.
1995: Masao Hirose; Keisuke Akagi; R Hasegawa; M Yaono; T Satoh; Y Hara; K Wakabayashi; Nobuyuki Ito
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats.
Carcinogenesis 1995;16(2):217-21.
1995: Nobuyuki Ito; R Hasegawa; E Asakawa; Masao Hirose; Katsumi Imaida; A Hagiwara
Enhancement of rat liver cell foci development by combined treatment with heterocyclic amines at low doses.
Princess Takamatsu symposia 1995;23():251-9.
1994: Masao Hirose; Toru Hoshiya; Keisuke Akagi; Mitsuru Futakuchi; Nobuyuki Ito
Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz[alpha]anthracene.
Cancer letters 1994;83(1-2):149-56.
1994: K Takaba; Masao Hirose; Kumiko Ogawa; K Hakoi; S Fukushima
Modification of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(6):499-503.
1994: E Asakawa; Masao Hirose; A Hagiwara; Satoru Takahashi; Nobuyuki Ito
Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats.
International journal of cancer. Journal international du cancer 1994;56(1):146-52.
1994: Y Yoshida; Masao Hirose; K Takaba; J Kimura; Nobuyuki Ito
Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methyl-N'-nitro-N-nitrosoguanidine pre-treatment.
International journal of cancer. Journal international du cancer 1994;56(1):124-8.
1994: Mayumi Kawabe; K Takaba; Y Yoshida; Masao Hirose
Effects of combined treatment with phenolic compounds and sodium nitrite on two-stage carcinogenesis and cell proliferation in the rat stomach.
Japanese journal of cancer research : Gann 1994;85(1):17-25.
1993: Nobuyuki Ito; Masao Hirose; Satoru Takahashi
Cell proliferation and forestomach carcinogenesis.
Environmental health perspectives 1993;101 Suppl 5():107-10.
1993: M Kagawa; K Hakoi; A Yamamoto; Mitsuru Futakuchi; Masao Hirose
Comparison of reversibility of rat forestomach lesions induced by genotoxic and non-genotoxic carcinogens.
Japanese journal of cancer research : Gann 1993;84(11):1120-9.
1993: Masao Hirose; H Yada; K Hakoi; Satoru Takahashi; Nobuyuki Ito
Modification of carcinogenesis by alpha-tocopherol, t-butylhydroquinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model.
Carcinogenesis 1993;14(11):2359-64.
1993: Masao Hirose; Toru Hoshiya; Keisuke Akagi; Satoru Takahashi; Y Hara; Nobuyuki Ito
Effects of green tea catechins in a rat multi-organ carcinogenesis model.
Carcinogenesis 1993;14(8):1549-53.
1993: Mayumi Kawabe; Seiko Tamano; M A Shibata; Masao Hirose; S Fukushima; Nobuyuki Ito
Subchronic toxicity study of methyl hesperidin in mice.
Toxicology letters 1993;69(1):37-44.
1993: M Tatematsu; M Ichinose; S Tsukada; N Kakei; Satoru Takahashi; Kumiko Ogawa; Masao Hirose; C Furihata; K Miki; K Kurokawa
DNA methylation of the pepsinogen 1 gene during rat glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine or catechol.
Carcinogenesis 1993;14(7):1415-9.
1993: M A Shibata; Masao Hirose; A Masuda; T Kato; M Mutai; Nobuyuki Ito
Modification of BHA forestomach carcinogenesis in rats: inhibition by diethylmaleate or indomethacin and enhancement by a retinoid.
Carcinogenesis 1993;14(7):1265-9.
1993: Masao Hirose; Keisuke Akagi; R Hasegawa; T Satoh; Y Nihro; Tokutaro Miki; T Sugimura; Nobuyuki Ito
Strong inhibition of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole-induced mutagenesis and hepatocarcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone.
Japanese journal of cancer research : Gann 1993;84(5):481-4.
1993: M A Shibata; Tomoyuki Shirai; E Asakawa; Masao Hirose; S Fukushima
Inhibition by dehydroepiandrosterone of butylated hydroxyanisole (BHA) promotion of rat-bladder carcinogenesis and enhancement of BHA-induced forestomach hyperplasia.
International journal of cancer. Journal international du cancer 1993;53(5):819-23.
1993: Masao Hirose; S Fukushima; Harunari Tanaka; E Asakawa; Satoru Takahashi; Nobuyuki Ito
Carcinogenicity of catechol in F344 rats and B6C3F1 mice.
Carcinogenesis 1993;14(3):525-9.
1993: M A Shibata; Masao Hirose; M Kagawa; P Boonyaphiphat; Nobuyuki Ito
Enhancing effect of concomitant L-ascorbic acid administration on BHA-induced forestomach carcinogenesis in rats.
Carcinogenesis 1993;14(2):275-80.
1993: Masao Hirose; Harunari Tanaka; Satoru Takahashi; Mitsuru Futakuchi; S Fukushima; Nobuyuki Ito
Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model.
Cancer research 1993;53(1):32-7.
1993: Masao Hirose; Tomoyuki Shirai; Satoru Takahashi; Kumiko Ogawa; Nobuyuki Ito
Organ-specific modification of carcinogenesis by antioxidants in rats.
Basic life sciences 1993;61():181-8.
1993: S Okazaki; Toru Hoshiya; Satoru Takahashi; Mitsuru Futakuchi; K Saito; Masao Hirose
Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.
Teratogenesis, carcinogenesis, and mutagenesis 1993;13(3):127-37.
1992: Seiko Tamano; Masao Hirose; Harunari Tanaka; E Asakawa; Kumiko Ogawa; Nobuyuki Ito
Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol.
Japanese journal of cancer research : Gann 1992;83(12):1279-85.
1992: Masao Hirose; Mayumi Kawabe; M Shibata; Satoru Takahashi; S Okazaki; Nobuyuki Ito
Influence of caffeic acid and other o-dihydroxybenzene derivatives on N-methyl-N'-nitro-N-nitrosoguanidine-initiated rat forestomach carcinogenesis.
Carcinogenesis 1992;13(10):1825-8.
1992: Satoru Takahashi; K Hakoi; H Yada; Masao Hirose; Nobuyuki Ito; S Fukushima
Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats.
Carcinogenesis 1992;13(9):1513-8.
1992: R Hasegawa; Danai Tiwawech; Masao Hirose; K Takaba; Toru Hoshiya; Tomoyuki Shirai; Nobuyuki Ito
Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses.
Japanese journal of cancer research : Gann 1992;83(5):431-7.
1992: Masao Hirose; S Wada; S Yamaguchi; A Masuda; S Okazaki; Nobuyuki Ito
Reversibility of catechol-induced rat glandular stomach lesions.
Cancer research 1992;52(4):787-90.
1992: M A Shibata; S Fukushima; E Asakawa; Masao Hirose; Nobuyuki Ito
The modifying effects of indomethacin or ascorbic acid on cell proliferation induced by different types of bladder tumor promoters in rat urinary bladder and forestomach mucosal epithelium.
Japanese journal of cancer research : Gann 1992;83(1):31-9.
1992: A Hagiwara; E Asakawa; Y Kurata; Masashi Sano; Masao Hirose; Nobuyuki Ito
Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats.
Toxicologic pathology 1992;20(2):197-204.
1991: M A Shibata; Masao Hirose; Harunari Tanaka; E Asakawa; Tomoyuki Shirai; Nobuyuki Ito
Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment.
Japanese journal of cancer research : Gann 1991;82(11):1211-9.
1991: A Hagiwara; Masao Hirose; Satoru Takahashi; Kumiko Ogawa; Tomoyuki Shirai; Nobuyuki Ito
Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6N x C3H/HeN F1 mice.
Cancer research 1991;51(20):5655-60.
1991: Masao Hirose; S Uwagawa; K Ozaki; K Takaba; Nobuyuki Ito
Effects of butylated hydroxyanisole pretreatment on low dose N-methyl-N'-nitro-N-nitrosoguanidine- or N,N-dibutylnitrosamine-induced rat forestomach or esophageal carcinogenesis.
Carcinogenesis 1991;12(10):1773-6.
1991: Masao Hirose; K Ozaki; K Takaba; S Fukushima; Tomoyuki Shirai; Nobuyuki Ito
Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model.
Carcinogenesis 1991;12(10):1917-21.
1991: A Nakamura; Tomoyuki Shirai; Satoru Takahashi; Kumiko Ogawa; Masao Hirose; Nobuyuki Ito
Lack of modification by naturally occurring antioxidants of 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.
Cancer letters 1991;58(3):241-6.
1991: S Fukushima; M A Shibata; Masao Hirose; T Kato; M Tatematsu; Nobuyuki Ito
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Japanese journal of cancer research : Gann 1991;82(7):784-92.
1991: S Fukushima; A Hagiwara; Masao Hirose; S Yamaguchi; Danai Tiwawech; Nobuyuki Ito
Modifying effects of various chemicals on preneoplastic and neoplastic lesion development in a wide-spectrum organ carcinogenesis model using F344 rats.
Japanese journal of cancer research : Gann 1991;82(6):642-9.
1991: Masao Hirose; M Mutai; Satoru Takahashi; M Yamada; S Fukushima; Nobuyuki Ito
Effects of phenolic antioxidants in low dose combination on forestomach carcinogenesis in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer research 1991;51(3):824-7.
1990: Katsumi Imaida; Masao Hirose; S Yamaguchi; Satoru Takahashi; Nobuyuki Ito
Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis in F344 male rats.
Cancer letters 1990;55(1):53-9.
1990: S Wada; Masao Hirose; Satoru Takahashi; S Okazaki; Nobuyuki Ito
Para-methoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis.
Carcinogenesis 1990;11(10):1891-4.
1990: R Hasegawa; Fumio Furukawa; Kazuhiro Toyoda; Mika Takahashi; Y Hayashi; Masao Hirose; N Ito
Inhibitory effects of antioxidants on N-bis(2-hydroxypropyl)nitrosamine-induced lung carcinogenesis in rats.
Japanese journal of cancer research : Gann 1990;81(9):871-7.
1990: Masao Hirose; S Fukushima; R Hasegawa; T Kato; Harunari Tanaka; Nobuyuki Ito
Effects of sodium nitrite and catechol or 3-methoxycatechol in combination on rat stomach epithelium.
Japanese journal of cancer research : Gann 1990;81(9):857-61.
1990: Y Kurata; S Fukushima; R Hasegawa; Masao Hirose; M Shibata; Tomoyuki Shirai; Nobuyuki Ito
Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants.
Japanese journal of cancer research : Gann 1990;81(8):754-9.
1990: M A Shibata; Masao Hirose; M Yamada; M Tatematsu; S Uwagawa; Nobuyuki Ito
Epithelial cell proliferation in rat forestomach and glandular stomach mucosa induced by catechol and analogous dihydroxybenzenes.
Carcinogenesis 1990;11(6):997-1000.
1990: Masao Hirose; A Masuda; Nobuyuki Ito; K Kamano; Harumi Okuyama
Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethyl-hydrazine (DMH)-induced mammary gland and colon carcinogenesis in female SD rats.
Carcinogenesis 1990;11(5):731-5.
1990: M A Shibata; M Yamada; Masao Hirose; E Asakawa; M Tatematsu; Nobuyuki Ito
Early proliferative responses of forestomach and glandular stomach of rats treated with five different phenolic antioxidants.
Carcinogenesis 1990;11(3):425-9.
1990: Masao Hirose; S Fukushima; Tomoyuki Shirai; R Hasegawa; T Kato; Harunari Tanaka; E Asakawa; Nobuyuki Ito
Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice.
Japanese journal of cancer research : Gann 1990;81(3):207-12.
1990: Masao Hirose; A Masuda; R Hasegawa; S Wada; Nobuyuki Ito
Regression of butylated hydroxyanisole (BHA)-induced hyperplasia but not dysplasia in the forestomach of hamsters.
Carcinogenesis 1990;11(2):239-44.
1990: Nobuyuki Ito; Masao Hirose; A Hagiwara; Satoru Takahashi
Carcinogenicity and modification of carcinogenic response by antioxidants.
Basic life sciences 1990;52():183-94.
1989: Nobuyuki Ito; Masao Hirose; M Shibata; Harunari Tanaka; Tomoyuki Shirai
Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2'-dimethyl-4-aminobiphenyl, 2,2'-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea.
Carcinogenesis 1989;10(12):2255-9.
1989: Masao Hirose; M Kagawa; Kumiko Ogawa; A Yamamoto; Nobuyuki Ito
Antagonistic effect of diethylmaleate on the promotion of forestomach carcinogenesis by butylated hydroxyanisole (BHA) in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1989;10(12):2223-6.
1989: S Yamaguchi; Masao Hirose; S Fukushima; R Hasegawa; Nobuyuki Ito
Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine.
Cancer research 1989;49(21):6015-8.
1989: Masao Hirose; S Yamaguchi; S Fukushima; R Hasegawa; Satoru Takahashi; Nobuyuki Ito
Promotion by dihydroxybenzene derivatives of N-methyl-N'-nitro-N-nitrosoguanidine-induced F344 rat forestomach and glandular stomach carcinogenesis.
Cancer research 1989;49(18):5143-7.
1989: Masao Hirose; Y Kurata; M Yamada; Tomoyuki Shirai; Nobuyuki Ito; T Ohsawa
Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats.
Cancer letters 1989;47(1-2):141-7.
1989: Nobuyuki Ito; Masao Hirose
Antioxidants--carcinogenic and chemopreventive properties.
Advances in cancer research 1989;53():247-302.
1988: Masao Hirose; A Hagiwara; K Inoue; Nobuyuki Ito; Hideo Kaneko; K Saito; H Matsunaga; N Isobe; A Yoshitake; J Miyamoto
Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces.
Toxicology 1988;53(1):33-43.
1988: Katsumi Imaida; S Fukushima; K Inoue; T Masui; Masao Hirose; Nobuyuki Ito
Modifying effects of concomitant treatment with butylated hydroxyanisole or butylated hydroxytoluene on N,N-dibutylnitrosamine-induced liver, forestomach and urinary bladder carcinogenesis in F344 male rats.
Cancer letters 1988;43(3):167-72.
1988: Masao Hirose; S Fukushima; Y Kurata; Hiroyuki Tsuda; M Tatematsu; Nobuyuki Ito
Modification of N-methyl-N'-nitro-N-nitrosoguanidine-induced forestomach and glandular stomach carcinogenesis by phenolic antioxidants in rats.
Cancer research 1988;48(18):5310-5.
1988: S Fukushima; Seiko Tamano; M A Shibata; Y Kurata; Masao Hirose; Nobuyuki Ito
The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder.
Carcinogenesis 1988;9(7):1203-6.
1988: Masao Hirose; A Masuda; S Fukushima; Nobuyuki Ito
Effects of subsequent antioxidant treatment on 7,12-dimethylbenz[a]anthracene-initiated carcinogenesis of the mammary gland, ear duct and forestomach in Sprague-Dawley rats.
Carcinogenesis 1988;9(1):101-4.
1987: Masao Hirose; A Masuda; Hiroyuki Tsuda; S Uwagawa; Nobuyuki Ito
Enhancement of BHA-induced proliferative rat forestomach lesion development by simultaneous treatment with other antioxidants.
Carcinogenesis 1987;8(11):1731-5.
1987: Masao Hirose; Y Kurata; Hiroyuki Tsuda; S Fukushima; Nobuyuki Ito
Catechol strongly enhances rat stomach carcinogenesis: a possible new environmental stomach carcinogen.
Japanese journal of cancer research : Gann 1987;78(11):1144-9.
1987: Tomoyuki Shirai; S Fukushima; Masao Hirose; M Ohshima; Nobuyuki Ito
Epithelial lesions of the urinary bladder in three hundred and thirteen autopsy cases.
Japanese journal of cancer research : Gann 1987;78(10):1073-80.
1987: Nobuyuki Ito; Masao Hirose
The role of antioxidants in chemical carcinogenesis.
Japanese journal of cancer research : Gann 1987;78(10):1011-26.
1987: Masao Hirose; T Inoue; A Masuda; Hiroyuki Tsuda; Nobuyuki Ito
Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia--complete inhibition by diethylmaleate in a 5-week feeding study.
Carcinogenesis 1987;8(10):1555-8.