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Kiichi Hirota

Research Profile

Chemicals & Drugs

Anatomy

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Oxidation-Reduction

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Mouse

Physiology

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TOP 3
Yu Liu; Toshiharu Sakurai; Manabu Fukumoto; Hiroaki Higashitsuji; Hisako Higashitsuji; Kiichi Hirota; Katsuhiko Itoh; Kazuhiko Koike; Jun Fujita
Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.
Karin Kato; Toshiyuki Mizota; Kiichi Hirota; Kazuhiko Fukuda
Successful perioperative management of a patient with primary systemic carnitine deficiency: a case report.
Masami Sato; Gotaro Shirakami; Hiroko Tanabe; Kiichi Hirota; Masahiro Kakuyama; Kazuhiko Fukuda
[Safety in general anesthesia for ambulatory electroconvulsive therapy].

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2013: Yu Liu; Toshiharu Sakurai; Manabu Fukumoto; Hiroaki Higashitsuji; Hisako Higashitsuji; Kiichi Hirota; Katsuhiko Itoh; Kazuhiko Koike; Jun Fujita
Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1.
Biochemical and biophysical research communications 2013;432(1):22-7.
2013: Karin Kato; Toshiyuki Mizota; Kiichi Hirota; Kazuhiko Fukuda
Successful perioperative management of a patient with primary systemic carnitine deficiency: a case report.
Journal of anesthesia 2013;27(1):141-2.
2013: Masami Sato; Gotaro Shirakami; Hiroko Tanabe; Kiichi Hirota; Masahiro Kakuyama; Kazuhiko Fukuda
[Safety in general anesthesia for ambulatory electroconvulsive therapy].
Masui. The Japanese journal of anesthesiology 2013;62(1):52-9.
2012: Kazuto Yamashita; Kiichi Hirota; Hisanari Ishii; Masami Sato; Hiroko Tanabe; Kazuhiko Fukuda
Takotsubo cardiomyopathy during ambulatory anesthesia for bladder hydrodistension therapy -A case report-.
Korean journal of anesthesiology 2012;62(5):484-7.
2012: Hiroshi Harada; Kiichi Hirota; Masahiro Inoue; Satoshi Itasaka; W Gillies McKenna; Akiyo Morinibu; Ruth J Muschel; Guangfei Ou; Kazumi Shinomiya; Michio Yoshimura; Lihua Zeng; Yuxi Zhu; Masahiro Hiraoka
Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels.
Nature communications 2012;3():783.
2011: Hiroki Daijo; Kazuhiko Fukuda; Hiroshi Harada; Shinichi Kai; Shun Kishimoto; Kengo Suzuki; Satoshi Takabuchi; Tomoharu Tanaka; Takuhiko Wakamatsu; Takehiko Adachi; Kiichi Hirota
Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner.
European journal of pharmacology 2011;667(1-3):144-52.
2011: Shun Kishimoto; Kiichi Hirota; Hajime Segawa; Kazuhiko Fukuda
Ectopic ACTH syndrome revealed as severe hypokalemia and persistent hypertension during the perioperative period: a case report.
Journal of anesthesia 2011;25(1):104-7.
2010: H Shinohara; Kiichi Hirota; Masami Sato; Masahiro Kakuyama; Kazuhiro Fukuda
Monitored anesthesia care with dexmedetomidine of a patient with severe pulmonary arterial hypertension for inguinal hernioplasty.
Journal of anesthesia 2010;24(4):611-3.
2010: Tokito Koga; Mariko Miyao; Masami Sato; Kiichi Hirota; Masahiro Kakuyama; Hiroko Tanabe; Kazuhiko Fukuda
Pituitary apoplexy during general anesthesia in beach chair position for shoulder joint arthroplasty.
Journal of anesthesia 2010;24(3):476-8.
2010: Tomoharu Tanaka; Takuhiko Wakamatsu; Hiroki Daijo; Seiko Oda; Shinichi Kai; Takehiko Adachi; Shinae Kizaka-Kondoh; Kazuhiko Fukuda; Kiichi Hirota
Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;298(3):R661-71.
2010: Tomoharu Tanaka; Satoshi Takabuchi; Kenichiro Nishi; Seiko Oda; Takuhiko Wakamatsu; Hiroki Daijo; Kazuhiko Fukuda; Kiichi Hirota
The intravenous anesthetic propofol inhibits lipopolysaccharide-induced hypoxia-inducible factor 1 activation and suppresses the glucose metabolism in macrophages.
Journal of anesthesia 2010;24(1):54-60.
2009: Takuhiko Wakamatsu; Tomoharu Tanaka; Seiko Oda; Kenichiro Nishi; Hiroshi Harada; Hiroki Daijo; Satoshi Takabuchi; Shinichi Kai; Kazuhiko Fukuda; Kiichi Hirota
The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation.
European journal of pharmacology 2009;617(1-3):17-22.
2009: Shinae Kizaka-Kondoh; Satoshi Itasaka; Lihua Zeng; Shotaro Tanaka; Tao Zhao; Yumi Takahashi; Keiko Shibuya; Kiichi Hirota; Gregg L Semenza; Masahiro Hiraoka
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(10):3433-41.
2009: Seiko Oda; Tomoyuki Oda; Satoshi Takabuchi; Kenichiro Nishi; Takuhiko Wakamatsu; Tomoharu Tanaka; Takehiko Adachi; Kazuhiko Fukuda; Ryuji Nohara; Kiichi Hirota
The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells.
European journal of pharmacology 2009;606(1-3):130-6.
2009: Yusuke Hara; Kiichi Hirota; Kazuhiko Fukuda
Successful airway management with use of a laryngeal mask airway in a patient with CHARGE syndrome.
Journal of anesthesia 2009;23(4):630-2.
2008: Motohide Kimura; Satoshi Takabuchi; Tomoharu Tanaka; Miyahiko Murata; Kenichiro Nishi; Seiko Oda; Tomoyuki Oda; Michiyuki Kanai; Kazuhiko Fukuda; Shinae Kizaka-Kondoh; Takehiko Adachi; Arimichi Takabayashi; Gregg L Semenza; Kiichi Hirota
n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems.
The Biochemical journal 2008;411(1):97-105.
2008: Seiko Oda; Tomoyuki Oda; Kenichiro Nishi; Satoshi Takabuchi; Takuhiko Wakamatsu; Tomoharu Tanaka; Takehiko Adachi; Kazuhiko Fukuda; Gregg L Semenza; Kiichi Hirota
Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner.
PloS one 2008;3(5):e2215.
2007: Piyanart Sommani; Kouhei Yamashita; Takashi Miyoshi; Hiroko Tsunemine; Tsutomu Kodaki; Hiroko Mori; Kiichi Hirota; Toshiyuki Arai; Masataka Sasada; Keisuke Makino
Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation.
Biological & pharmaceutical bulletin 2007;30(11):2181-4.
2006: Kiichi Hirota; Gregg L Semenza
Regulation of angiogenesis by hypoxia-inducible factor 1.
Critical reviews in oncology/hematology 2006;59(1):15-26.
2005: Kiichi Hirota; Gregg L Semenza
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases.
Biochemical and biophysical research communications 2005;338(1):610-6.
2005: Taizo Hisano; Tsunehisa Namba; Mitsuko Hashiguchi-Ikeda; Tatsuya Ito; Kiichi Hirota; Kazuhiko Fukuda
Inhibition of E-selectin-mediated leukocyte adhesion by volatile anesthetics in a static condition.
Journal of anesthesia 2005;19(1):1-6.
2004: Tatsuya Itoh; Kiichi Hirota; Taizo Hisano; Tsunehisa Namba; Kazuhiko Fukuda
The volatile anesthetics halothane and isoflurane differentially modulate proinflammatory cytokine-induced p38 mitogen-activated protein kinase activation.
Journal of anesthesia 2004;18(3):203-9.
2002: Kiichi Hirota
Hypoxia-inducible factor 1, a master transcription factor of cellular hypoxic gene expression.
Journal of anesthesia 2002;16(2):150-9.
2001: Takafumi Itoh; Tsunehisa Namba; Kazuhiko Fukuda; Gregg L Semenza; Kiichi Hirota
Reversible inhibition of hypoxia-inducible factor 1 activation by exposure of hypoxic cells to the volatile anesthetic halothane.
FEBS letters 2001;509(2):225-9.
2001: Kiichi Hirota; Masayuki Murata; Takafumi Itoh; Junji Yodoi; K Fukuda
Redox-sensitive transactivation of epidermal growth factor receptor by tumor necrosis factor confers the NF-kappa B activation.
The Journal of biological chemistry 2001;276(28):25953-8.
2001: H Dekigai; Md. Kaimul Ahsan; Jie Bai; Masaki Tanito; Hiroshi Masutani; Kiichi Hirota; H Matsui; M Murakami; Junji Yodoi
Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes.
Free radical research 2001;35(1):23-30.
2001: Kiichi Hirota; Gregg L Semenza
Rac1 activity is required for the activation of hypoxia-inducible factor 1.
The Journal of biological chemistry 2001;276(24):21166-72.
2001: Kiichi Hirota; Masayuki Murata; Takafumi Itoh; Junji Yodoi; Kazuhiko Fukuda
An endogenous redox molecule, thioredoxin, regulates transactivation of epidermal growth factor receptor and activation of NF-kappaB by lysophosphatidic acid.
FEBS letters 2001;489(2-3):134-8.
2001: Toshiyuki Arai; Nobuyuki Endo; K Yamashita; M Sasada; Hiroko Mori; Hisanari Ishii; Kiichi Hirota; Keisuke Makino; Kazuhiko Fukuda
6-formylpterin, a xanthine oxidase inhibitor, intracellularly generates reactive oxygen species involved in apoptosis and cell proliferation.
Free radical biology & medicine 2001;30(3):248-59.
2000: Kiichi Hirota; Md. Kaimul Ahsan; Toshiyuki Arai; Hisanari Ishii; Jie Bai; Takafumi Itoh; Kazuhiko Fukuda; Junji Yodoi
Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes.
Biochemical and biophysical research communications 2000;275(3):825-30.
2000: Kiichi Hirota; Minoru MATSUI; Masayuki Murata; Y Takashima; F S Cheng; Takafumi Itoh; Kazuhiko Fukuda; Junji Yodoi; Y Junji
Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-kappaB, AP-1, and CREB activation in HEK293 cells.
Biochemical and biophysical research communications 2000;274(1):177-82.
2000: Tsunehisa Namba; Takahiro M Ishii; M Ikeda; Taizo Hisano; Takafumi Itoh; Kiichi Hirota; John P Adelman; Kazuhiko Fukuda
Inhibition of the human intermediate conductance Ca(2+)-activated K(+) channel, hIK1, by volatile anesthetics.
European journal of pharmacology 2000;395(2):95-101.
2000: Hiroko Mori; Toshiyuki Arai; Kiichi Hirota; Hisanari Ishii; Nobuyuki Endo; Keisuke Makino; Kazuhiko Fukuda
Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macrophages.
Biochimica et biophysica acta 2000;1474(1):93-9.
2000: J Takeuchi; Kiichi Hirota; Takafumi Itoh; Reiko Shinkura; K Kitada; Junji Yodoi; T Namba; Kazuhiko Fukuda
Thioredoxin inhibits tumor necrosis factor- or interleukin-1-induced NF-kappaB activation at a level upstream of NF-kappaB-inducing kinase.
Antioxidants & redox signaling 2000;2(1):83-92.
1999: Masaya Ueno; Hiroshi Masutani; R J Arai; Akira Yamauchi; Kiichi Hirota; T Sakai; Takashi Inamoto; Yoshio Yamaoka; Junji Yodoi; Toshio Nikaido
Thioredoxin-dependent redox regulation of p53-mediated p21 activation.
The Journal of biological chemistry 1999;274(50):35809-15.
1999: Kiichi Hirota; A Nishiyama; Junji Yodoi
[Reactive oxygen intermediates, thioredoxin, and Ref-1 as effector molecules in cellular signal transduction].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1999;44(15 Suppl):2414-9.
1999: Takayuki Nakamura; T Ohno; Kiichi Hirota; Akira Nishiyama; Md. Kaimul Ahsan; Hiromi Wada; Junji Yodoi
Mouse glutaredoxin - cDNA cloning, high level expression in E. coli and its possible implication in redox regulation of the DNA binding activity in transcription factor PEBP2.
Free radical research 1999;31(4):357-65.
1999: Kiichi Hirota; Masayuki Murata; Y Sachi; Md. Kaimul Ahsan; J Takeuchi; Kazuhiro J Mori; Junji Yodoi
Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB.
The Journal of biological chemistry 1999;274(39):27891-7.
1999: Akira Nishiyama; Minoru MATSUI; Shingo Iwata; Kiichi Hirota; Hiroshi Masutani; Md. Kaimul Ahsan; Yasushi Takagi; Hiroshi Sono; Yasuhiro Gon; Junji Yodoi
Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression.
The Journal of biological chemistry 1999;274(31):21645-50.
1999: Y Takashima; Kiichi Hirota; Md. Kaimul Ahsan; Tetsuya Nakamura; K Akiyama; F S Cheng; Michiyuki Maeda; Junji Yodoi
Differential expression of glutaredoxin and thioredoxin during monocytic differentiation.
Immunology letters 1999;68(2-3):397-401.
1999: Akira Nishiyama; T Ohno; Shingo Iwata; Minoru MATSUI; Kiichi Hirota; Hiroshi Masutani; Md. Kaimul Ahsan; Junji Yodoi
Demonstration of the interaction of thioredoxin with p40phox, a phagocyte oxidase component, using a yeast two-hybrid system.
Immunology letters 1999;68(1):155-9.
1997: T Maruyama; Y Kitaoka; Y Sachi; K Nakanoin; Kiichi Hirota; T Shiozawa; Y Yoshimura; Shingo Fujii; Junji Yodoi
Thioredoxin expression in the human endometrium during the menstrual cycle.
Molecular human reproduction 1997;3(11):989-93.
1997: Tomoyuki Tanaka; Y Nishiyama; Kunihiko Okada; Kiichi Hirota; Minoru MATSUI; Junji Yodoi; Hiroshi Hiai; Shinya Toyokuni
Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion.
Laboratory investigation; a journal of technical methods and pathology 1997;77(2):145-55.
1997: Y Akamatsu; T Ohno; Kiichi Hirota; Hiroshi Kagoshima; Junji Yodoi; Shigesada Katsuya
Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues.
The Journal of biological chemistry 1997;272(23):14497-500.
1997: Kiichi Hirota; Minoru MATSUI; S Iwata; A Nishiyama; Kazuhiro J Mori; Junji Yodoi
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3633-8.
1997: Shingo Iwata; Toshiyuki Hori; N Sato; Kiichi Hirota; Tetsuro Sasada; Akira Mitsui; T Hirakawa; Junji Yodoi
Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(7):3108-17.
1996: Hiroshi Masutani; Kiichi Hirota; Tetsuro Sasada; Y Ueda-Taniguchi; Y Taniguchi; Hiroshi Sono; Junji Yodoi
Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax.
Immunology letters 1996;54(2-3):67-71.
1996: Tetsuro Sasada; Shingo Iwata; N Sato; Y Kitaoka; Kiichi Hirota; K Nakamura; Akira Nishiyama; Y Taniguchi; Arimichi Takabayashi; Junji Yodoi
Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.
The Journal of clinical investigation 1996;97(10):2268-76.
1995: Minoru MATSUI; Y Taniguchi; Kiichi Hirota; Makoto M Taketo; Junji Yodoi
Structure of the mouse thioredoxin-encoding gene and its processed pseudogene.
Gene 1995;152(2):165-71.
1995: Y Sachi; Kiichi Hirota; Hiroshi Masutani; K Toda; T Okamoto; M Takigawa; Junji Yodoi
Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells.
Immunology letters 1995;44(2-3):189-93.