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Vanessa Hirsch

Research Profile

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Takeo Kuwata; Ikumi Enomoto; Vanessa M Hirsch; Ilnour Ourmanov; Hironori Sato; Kaori Takaki; Fan Wu; Masaru Yokoyama; Kazuhisa Yoshimura; Shuzo Matsushita
Conformational epitope consisting of the v3 and v4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses.
Que Dang; Robert M Goeken; Jason M Brenchley; Charles R Brown; Alicia Buckler-White; Ranjini Iyengar; Bernard A P Lafont; Kenta Matsuda; Ronald Plishka; Matthew F Starost; Sonya Whitted; Vanessa M Hirsch
Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.
Fan Wu; Scott T Aoki; Charles R Brown; Alicia Buckler-White; Robert M Goeken; Ranjini Iyengar; Takeo Kuwata; Ilnour Ourmanov; Ronald Plishka; Vanessa M Hirsch
Sequential evolution and escape from neutralization of simian immunodeficiency virus SIVsmE660 clones in rhesus macaques.

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All Publications

2013: Takeo Kuwata; Ikumi Enomoto; Vanessa M Hirsch; Ilnour Ourmanov; Hironori Sato; Kaori Takaki; Fan Wu; Masaru Yokoyama; Kazuhisa Yoshimura; Shuzo Matsushita
Conformational epitope consisting of the v3 and v4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses.
Journal of virology 2013;87(10):5424-36.
2012: Que Dang; Robert M Goeken; Jason M Brenchley; Charles R Brown; Alicia Buckler-White; Ranjini Iyengar; Bernard A P Lafont; Kenta Matsuda; Ronald Plishka; Matthew F Starost; Sonya Whitted; Vanessa M Hirsch
Development of neurological disease is associated with increased immune activation in simian immunodeficiency virus-infected macaques.
Journal of virology 2012;86(24):13795-9.
2012: Fan Wu; Scott T Aoki; Charles R Brown; Alicia Buckler-White; Robert M Goeken; Ranjini Iyengar; Takeo Kuwata; Ilnour Ourmanov; Ronald Plishka; Vanessa M Hirsch
Sequential evolution and escape from neutralization of simian immunodeficiency virus SIVsmE660 clones in rhesus macaques.
Journal of virology 2012;86(16):8835-47.
2012: Lilin Lai; David C Montefiori; Bernard Moss; Tracy L Nolen; George N Pavlakis; Rama Rao Amara; Patricia L Earl; Barbara K Felber; Guido Ferrari; Vanessa M Hirsch; Michael G Hudgens; Welkin E Johnson; Pamela A Kozlowski; Sue-Fen Kwa; Harriet L Robinson
SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses.
Vaccine 2012;30(9):1737-45.
2012: Dan H Barouch; Erik A Billings; Angela Carville; Guido Ferrari; Donald N Forthal; Jaap Goudsmit; Vanessa M Hirsch; M Justin Iampietro; Jerome H Kim; Hualin Li; Jinyan Liu; Diana M Lynch; Keith G Mansfield; Mary A Marovich; Lori F Maxfield; Ilnour Ourmanov; Maria G Pau; Mangala Rao; Merlin L Robb; Jerald C Sadoff; Adam SanMiguel; Hanneke Schuitemaker; Michael S Seaman; Donald Stablein; peter abbink; Nelson L Michael
Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys.
Nature 2012;482(7383):89-93.
2012: Lia Vassena; Giulia Cassina; Raffaello Cimbro; Anthony S Fauci; Vanessa M Hirsch; Bernard A Lafont; Mauro S Malnati; Huiyi Miao; Michel MORRE; Michael A Proschan; Paolo Lusso
Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques.
PLoS pathogens 2012;8(4):e1002636.
2011: Claudio Fenizia; Nicolò Binello; Stefano Cornara; Vanessa M Hirsch; Brandon F Keele; Zhong-Min Ma; Christopher J Miller; David Nichols; Poonam Pegu; Marjorie Robert-Guroff; Monica Vaccari; David Venzon; Genoveffa Franchini
TRIM5α does not affect simian immunodeficiency virus SIV(mac251) replication in vaccinated or unvaccinated Indian rhesus macaques following intrarectal challenge exposure.
Journal of virology 2011;85(23):12399-409.
2011: Nana F Bello; Vincent Dussupt; Vanessa M Hirsch; Paola Sette; Fan Wu; Fadila Bouamr
Distal leucines are key functional determinants of Alix-binding simian immunodeficiency virus SIV(smE543) and SIV(mac239) type 3 L domains.
Journal of virology 2011;85(21):11532-7.
2011: Carol Vinton; ruth woodward; Cristian Apetrei; Judith A Briant; Levelle D Harris; Richard Herbert; Vanessa M Hirsch; Nichole R Klatt; Ivona Pandrea; Brigitte E Sanders-Beer; Guido Silvestri; Jason M Brenchley
CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.
Journal of virology 2011;85(17):8702-8.
2011: L Jean Patterson; Mara Daltabuit-Test; Peng Xiao; Jun Zhao; William Hu; Ulrike Wille-Reece; Egidio Brocca-Cofano; Vaniambadi S Kalyanaraman; Irene Kalisz; Stephen Whitney; Eun Mi Lee; Ranajit Pal; David C Montefiori; Satya Dandekar; Robert A Seder; Mario Roederer; Roger W Wiseman; Vanessa M Hirsch; Marjorie Robert-Guroff
Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.
Virology 2011;411(1):87-102.
2010: Levelle D Harris; Nichole R Klatt; Carol Vinton; Judith A Briant; Brian Tabb; Kristin Ladell; Jeffrey Lifson; Jacob D Estes; David A Price; Vanessa M Hirsch; Jason M Brenchley
Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques.
Blood 2010;116(20):4148-57.
2010: Cristian Apetrei; Thaidra Gaufin; Rajeev Gautam; Carol Vinton; Vanessa M Hirsch; Mark Lewis; Jason Brenchley; Ivona Pandrea
Pattern of SIVagm infection in patas monkeys suggests that host adaptation to simian immunodeficiency virus infection may result in resistance to infection and virus extinction.
The Journal of infectious diseases 2010;202 Suppl 3():S371-6.
2010: Yanfang Zheng; Ilnour Ourmanov; Robert M Goeken; Sonya Whitted; Charles R Brown; Alicia Buckler-White; Ranjini Iyengar; Ronald Plishka; Vanessa M Hirsch
Correction of a carboxyl terminal simian immunodeficiency virus Nef frameshift mutation restores virus replication in macaques.
Virology 2010;401(2):207-14.
2010: Roland C Zahn; Melisa D Rett; Ming Li; Haili Tang; Birgit Korioth-Schmitz; Harikrishnan Balachandran; Robert White; Sarah Pryputniewicz; Norman L Letvin; Amitinder Kaur; David C Montefiori; Angela Carville; Vanessa M Hirsch; Jonathan S Allan; Joern schmitz
Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.
Blood 2010;115(15):3070-8.
2009: Jörn E Schmitz; Roland C Zahn; Charles R Brown; Melisa D Rett; Ming Li; Haili Tang; Sarah Pryputniewicz; Russell A Byrum; Amitinder Kaur; David C Montefiori; Jonathan S Allan; Simoy Goldstein; Vanessa M Hirsch
Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.
PLoS pathogens 2009;5(12):e1000691.
2009: Coreen M Beaumier; Levelle D Harris; Simoy Goldstein; Nichole R Klatt; Sonya Whitted; John McGinty; Cristian Apetrei; Ivona Pandrea; Vanessa M Hirsch; Jason M Brenchley
CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection.
Nature medicine 2009;15(8):879-85.
2009: Ilnour Ourmanov; Takeo Kuwata; Robert M Goeken; Simoy Goldstein; Ranjani Iyengar; Alicia Buckler-White; Bernard A P Lafont; Vanessa M Hirsch
Improved survival in rhesus macaques immunized with modified vaccinia virus Ankara recombinants expressing simian immunodeficiency virus envelope correlates with reduction in memory CD4+ T-cell loss and higher titers of neutralizing antibody.
Journal of virology 2009;83(11):5388-400.
2009: Takeo Kuwata; Yoshiaki Nishimura; Sonya Whitted; Ilnour Ourmanov; Charles R Brown; Que Dang; Alicia Buckler-White; Ranjini Iyengar; Jason M Brenchley; Vanessa M Hirsch
Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies.
PLoS pathogens 2009;5(4):e1000372.
2008: Roland Zahn; Melisa D Rett; Birgit Korioth-Schmitz; Yue Sun; Adam P Buzby; Simoy Goldstein; Charles R Brown; Russell A Byrum; Gordon J Freeman; Norman L Letvin; Vanessa M Hirsch; Joern schmitz
Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm.
Journal of virology 2008;82(23):11577-88.
2008: Que Dang; Robert M Goeken; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Russ Byrum; Brian Foley; Vanessa M Hirsch
Adaptive evolution of simian immunodeficiency viruses isolated from 2 conventional-progressor macaques with encephalitis.
The Journal of infectious diseases 2008;197(12):1695-700.
2008: Yanfang Zheng; Ilnour Ourmanov; Vanessa M Hirsch
Persistent transcription of a nonintegrating mutant of simian immunodeficiency virus in rhesus macrophages.
Virology 2008;372(2):291-9.
2008: Que Dang; Vanessa M Hirsch
Rapid disease progression to AIDS due to Simian immunodeficiency virus infection of macaques: host and viral factors.
Advances in pharmacology (San Diego, Calif.) 2008;56():369-98.
2007: Takeo Kuwata; Russ Byrum; Sonya Whitted; Robert M Goeken; Alicia Buckler-White; Ronald Plishka; Ranjini Iyengar; Vanessa M Hirsch
A rapid progressor-specific variant clone of simian immunodeficiency virus replicates efficiently in vivo only in the absence of immune responses.
Journal of virology 2007;81(17):8891-904.
2007: Rajeev Gautam; Anders Chase Carter; Nathalia Katz; Isolde F Butler; Mary Barnes; Atsuhiko Hasegawa; Marion S Ratterree; Guido Silvestri; Preston A Marx; Vanessa M Hirsch; Ivona Pandrea; Cristian Apetrei
In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaques.
Virology 2007;362(2):257-70.
2007: Charles R Brown; Meggan Czapiga; Juraj Kabat; Que Dang; Ilnour Ourmanov; Yoshiaki Nishimura; Malcolm Martin; Vanessa M Hirsch
Unique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS.
Journal of virology 2007;81(11):5594-606.
2007: Bernard A P Lafont; Christopher M McGraw; Sabriya A Stukes; Alicia Buckler-White; Ronald Plishka; Russ Byrum; Vanessa M Hirsch; Malcolm Martin
The locus encoding an oligomorphic family of MHC-A alleles (Mane-A*06/Mamu-A*05) is present at high frequency in several macaque species.
Immunogenetics 2007;59(3):211-23.
2007: Ivona Pandrea; Cristian Apetrei; Shari Gordon; Joseph Barbercheck; Jason Dufour; Rudolf Bohm; Beth Sumpter; Pierre Roques; Preston A Marx; Vanessa M Hirsch; Amitinder Kaur; Andrew Lackner; Ronald S Veazey; Guido Silvestri
Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts.
Blood 2007;109(3):1069-76.
2007: Yoshiaki Nishimura; Tatsuhiko Igarashi; Alicia Buckler-White; Charles Buckler; Hiromi Imamichi; Robert M Goeken; Wendy R Lee; Bernard A P Lafont; Russ Byrum; H Clifford Lane; Vanessa M Hirsch; Malcolm Martin
Loss of naïve cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques.
Journal of virology 2007;81(2):893-902.
2006: Ivona Pandrea; Guido Silvestri; Richard Onanga; Ronald S Veazey; Preston A Marx; Vanessa M Hirsch; Cristian Apetrei
Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differences.
Journal of medical primatology 2006;35(4-5):194-201.
2006: Simoy Goldstein; Charles R Brown; Ilnour Ourmanov; Ivona Pandrea; Alicia Buckler-White; Christopher Erb; Jayashree S. Nandi; Gabriel J Foster; Patrick Autissier; Joern schmitz; Vanessa M Hirsch
Comparison of simian immunodeficiency virus SIVagmVer replication and CD4+ T-cell dynamics in vervet and sabaeus African green monkeys.
Journal of virology 2006;80(10):4868-77.
2006: Ivona Pandrea; Cristian Apetrei; Jason Dufour; Nora Dillon; Joseph Barbercheck; Michael Metzger; Béatrice Jacquelin; Rudolf Bohm; Preston A Marx; Françoise Barre-Sinoussi; Vanessa M Hirsch; Michaela C Müller-Trutwin; Andrew Lackner; Ronald S Veazey
Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts.
Journal of virology 2006;80(10):4858-67.
2006: Takeo Kuwata; Houman Dehghani; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Tatsuhiko Igarashi; Joseph J Mattapallil; Mario Roederer; Vanessa M Hirsch
Infectious molecular clones from a simian immunodeficiency virus-infected rapid-progressor (RP) macaque: evidence of differential selection of RP-specific envelope mutations in vitro and in vivo.
Journal of virology 2006;80(3):1463-75.
2005: Hanwen Mao; Bernard A P Lafont; Tatsuhiko Igarashi; Yoshiaki Nishimura; Charlie Brown; Vanessa M Hirsch; Alicia Buckler-White; Reza Sadjadpour; Malcolm Martin
CD8+ and CD20+ lymphocytes cooperate to control acute simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys: modulation by major histocompatibility complex genotype.
Journal of virology 2005;79(23):14887-98.
2005: Brigitte E Beer; Charles R Brown; Sonya Whitted; Simoy Goldstein; Robert M Goeken; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch
Immunodeficiency in the absence of high viral load in pig-tailed macaques infected with Simian immunodeficiency virus SIVsun or SIVlhoest.
Journal of virology 2005;79(22):14044-56.
2005: Yoshiaki Nishimura; Charles R Brown; Joseph J Mattapallil; Tatsuhiko Igarashi; Alicia Buckler-White; Bernard A P Lafont; Vanessa M Hirsch; Mario Roederer; Malcolm Martin
Resting naive CD4+ T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(22):8000-5.
2005: Simoy Goldstein; Ilnour Ourmanov; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Russ Byrum; Vanessa M Hirsch
Plateau levels of viremia correlate with the degree of CD4+-T-cell loss in simian immunodeficiency virus SIVagm-infected pigtailed macaques: variable pathogenicity of natural SIVagm isolates.
Journal of virology 2005;79(8):5153-62.
2005: Dan H Barouch; Jennifer Powers; Diana M Truitt; Michael G Kishko; Janelle C Arthur; Fred W Peyerl; Marcelo J Kuroda; Darci A Gorgone; Michelle A Lifton; Carol I Lord; Vanessa M Hirsch; David C Montefiori; Angela Carville; Keith G Mansfield; Kevin Kunstman; Steven Wolinsky; Norman L Letvin
Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants.
Nature immunology 2005;6(3):247-52.
2004: Yoshiaki Nishimura; Tatsuhiko Igarashi; Olivia K Donau; Alicia Buckler-White; Charles Buckler; Bernard A P Lafont; Robert M Goeken; Simoy Goldstein; Vanessa M Hirsch; Malcolm Martin
Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12324-9.
2004: Jeffrey D Lifson; Jeffrey L Rossio; Michael Piatak; Julian W Bess; Elena Chertova; Douglas K Schneider; Vicky J Coalter; Barbara Poore; Rebecca F Kiser; Robert J Imming; Anthony J Scarzello; Louis E. Henderson; W Gregory Alvord; Vanessa M Hirsch; Raoul E Benveniste; Larry O Arthur
Evaluation of the safety, immunogenicity, and protective efficacy of whole inactivated simian immunodeficiency virus (SIV) vaccines with conformationally and functionally intact envelope glycoproteins.
AIDS research and human retroviruses 2004;20(7):772-87.
2004: Vanessa M Hirsch
What can natural infection of African monkeys with simian immunodeficiency virus tell us about the pathogenesis of AIDS?
AIDS reviews 2004;6(1):40-53.
2004: Vanessa M Hirsch; Sampa Santra; Simoy Goldstein; Ronald Plishka; Alicia Buckler-White; Aruna Seth; Ilnour Ourmanov; Charles R Brown; Ronald Engle; David Montefiori; Jennifer Glowczwskie; Kevin Kunstman; Steven Wolinsky; Norman L Letvin
Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques.
Journal of virology 2004;78(1):275-84.
2003: Tatsuhiko Igarashi; Hiromi Imamichi; Charles R Brown; Vanessa M Hirsch; Malcolm Martin
The emergence and characterization of macrophage-tropic SIV/HIV chimeric viruses (SHIVs) present in CD4+ T cell-depleted rhesus monkeys.
Journal of leukocyte biology 2003;74(5):772-80.
2003: Marcin Moniuszko; Charlie Brown; Ranajit Pal; Elzbieta Tryniszewska; Wen-Po Tsai; Vanessa M Hirsch; Genoveffa Franchini
High frequency of virus-specific CD8+ T cells in the central nervous system of macaques chronically infected with simian immunodeficiency virus SIVmac251.
Journal of virology 2003;77(22):12346-51.
2003: Yvette Edghill Spano; David Venzon; Tatiana S Karpova; James McNally; Janos Nacsa; Wen-Po Tsai; Elzbieta Tryniszewska; Marcin Moniuszko; Jody Manischewitz; Lisa R King; Steven J Snodgrass; John Parrish; Phillip Markham; Marsha Sowers; Derrick Martin; Mark G Lewis; Jay A Berzofsky; Igor M Belyakov; Bernard Moss; Jim Tartaglia; Mike Bray; Vanessa M Hirsch; Hana Golding; Genoveffa Franchini
Modeling a safer smallpox vaccination regimen, for human immunodeficiency virus type 1-infected patients, in immunocompromised macaques.
The Journal of infectious diseases 2003;188(8):1181-91.
2003: Houman Dehghani; Bridget A Puffer; Robert W Doms; Vanessa M Hirsch
Unique pattern of convergent envelope evolution in simian immunodeficiency virus-infected rapid progressor macaques: association with CD4-independent usage of CCR5.
Journal of virology 2003;77(11):6405-18.
2003: Jinjie Hu; William Switzer; Brian Foley; David L Robertson; Robert M Goeken; Bette T Korber; Vanessa M Hirsch; Brigitte E Beer
Characterization and comparison of recombinant simian immunodeficiency virus from drill (Mandrillus leucophaeus) and mandrill (Mandrillus sphinx) isolates.
Journal of virology 2003;77(8):4867-80.
2003: Tobias A Grimm; Brigitte E Beer; Vanessa M Hirsch; Kathleen A Clouse
Simian immunodeficiency viruses from multiple lineages infect human macrophages: implications for cross-species transmission.
Journal of acquired immune deficiency syndromes (1999) 2003;32(4):362-9.
2002: Sampa Santra; Dan H Barouch; Marcelo J Kuroda; Joern schmitz; Georgia R Krivulka; Kristin Beaudry; Carol I Lord; Michelle A Lifton; Linda S Wyatt; Bernard Moss; Vanessa M Hirsch; Norman L Letvin
Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection.
Journal of virology 2002;76(12):6376-81.
2002: Houman Dehghani; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch
The ITAM in Nef influences acute pathogenesis of AIDS-inducing simian immunodeficiency viruses SIVsm and SIVagm without altering kinetics or extent of viremia.
Journal of virology 2002;76(9):4379-89.
2002: Tatsuhiko Igarashi; Charles R Brown; Russ Byrum; Yoshiaki Nishimura; Yasuyuki Endo; Ronald Plishka; Charles Buckler; Alicia Buckler-White; Georgina Miller; Vanessa M Hirsch; Malcolm Martin
Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronous.
Journal of virology 2002;76(1):379-91.
2002: Ranajit Pal; David Venzon; Norman L Letvin; Sampa Santra; David C Montefiori; Neil R Miller; Elzbieta Tryniszewska; Mark G Lewis; Thomas C VanCott; Vanessa M Hirsch; ruth woodward; A Gibson; M Grace; E Dobratz; Phillip D Markham; Zdenek Hel; Janos Nacsa; M Klein; Jim Tartaglia; Genoveffa Franchini
ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency.
Journal of virology 2002;76(1):292-302.
2001: Brigitte E Beer; Brian Foley; Carla Kuiken; Zena Tooze; Robert M Goeken; Charles R Brown; J Hu; M St Claire; Bette T Korber; Vanessa M Hirsch
Characterization of novel simian immunodeficiency viruses from red-capped mangabeys from Nigeria (SIVrcmNG409 and -NG411).
Journal of virology 2001;75(24):12014-27.
2001: Jeffrey D Lifson; Jeffrey L Rossio; Michael Piatak; Tom` Parks; L Li; Rebecca F Kiser; Vicky J Coalter; B Fisher; Bernard M Flynn; S Czajak; Vanessa M Hirsch; Keith A Reimann; Joern schmitz; John Ghrayeb; Norbert Bischofberger; Martin A Nowak; R C Desrosiers; D Wodarz
Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment.
Journal of virology 2001;75(21):10187-99.
2001: Sally A Sharpe; Natasha Polyanskaya; Mike Dennis; Gerd Sutter; Tomás Hanke; V Erfle; Vanessa M Hirsch; Martin Cranage
Induction of simian immunodeficiency virus (SIV)-specific CTL in rhesus macaques by vaccination with modified vaccinia virus Ankara expressing SIV transgenes: influence of pre-existing anti-vector immunity.
The Journal of general virology 2001;82(Pt 9):2215-23.
2001: M Haddrick; Charles R Brown; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch; H Ginsberg
Biologic studies of chimeras of highly and moderately virulent molecular clones of simian immunodeficiency virus SIVsmPBj suggest a critical role for envelope in acute AIDS virus pathogenesis.
Journal of virology 2001;75(14):6645-59.
2001: Dan H Barouch; Sampa Santra; Marcelo J Kuroda; Joern schmitz; Ronald Plishka; Alicia Buckler-White; A E Gaitan; R Zin; J H Nam; Linda S Wyatt; Michelle A Lifton; Christine E Nickerson; Bernard Moss; David C Montefiori; Vanessa M Hirsch; Norman L Letvin
Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination.
Journal of virology 2001;75(11):5151-8.
2001: Dan H Barouch; A Craiu; Sampa Santra; Michael A Egan; Joern schmitz; Marcelo J Kuroda; Tong-Ming Fu; J H Nam; Linda S Wyatt; Michelle A Lifton; Georgia R Krivulka; Christine E Nickerson; Carol I Lord; Bernard Moss; Mark G Lewis; Vanessa M Hirsch; John W Shiver; Norman L Letvin
Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys.
Journal of virology 2001;75(5):2462-7.
2001: Tatsuhiko Igarashi; Charles R Brown; Yasuyuki Endo; Alicia Buckler-White; Ronald Plishka; N Bischofberger; Vanessa M Hirsch; Malcolm Martin
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(2):658-63.
2000: Simoy Goldstein; Ilnour Ourmanov; Charles R Brown; Brigitte E Beer; WR Elkins; Ronald Plishka; Alicia Buckler-White; Vanessa M Hirsch
Wide range of viral load in healthy african green monkeys naturally infected with simian immunodeficiency virus.
Journal of virology 2000;74(24):11744-53.
2000: Simoy Goldstein; Charles R Brown; Houman Dehghani; Jeffrey D Lifson; Vanessa M Hirsch
Intrinsic susceptibility of rhesus macaque peripheral CD4(+) T cells to simian immunodeficiency virus in vitro is predictive of in vivo viral replication.
Journal of virology 2000;74(20):9388-95.
2000: Leonid Margolis; Svetlana Glushakova; Claire Chougnet; G Shearer; Phillip Markham; Marjorie Robert-Guroff; R Benveniste; Christopher J Miller; Martin Cranage; Vanessa M Hirsch; Genoveffa Franchini
Replication of simian immunodeficiency virus (SIV) in ex vivo lymph nodes as a means to assess susceptibility of macaques in vivo.
Virology 2000;275(2):391-7.
2000: J Glamann; Vanessa M Hirsch
Characterization of a macaque recombinant monoclonal antibody that binds to a CD4-induced epitope and neutralizes simian immunodeficiency virus.
Journal of virology 2000;74(15):7158-63.
2000: Brigitte E Beer; Elizabeth Bailes; G Dapolito; BJ Campbell; Robert M Goeken; Michael K Axthelm; P D Markham; J Bernard; D Zagury; G Franchini; Paul M Sharp; Vanessa M Hirsch
Patterns of genomic sequence diversity among their simian immunodeficiency viruses suggest that L'Hoest monkeys (Cercopithecus lhoesti) are a natural lentivirus reservoir.
Journal of virology 2000;74(8):3892-8.
2000: Ilnour Ourmanov; M Bilska; Vanessa M Hirsch; David C Montefiori
Recombinant modified vaccinia virus ankara expressing the surface gp120 of simian immunodeficiency virus (SIV) primes for a rapid neutralizing antibody response to SIV infection in macaques.
Journal of virology 2000;74(6):2960-5.
2000: Ilnour Ourmanov; Charles R Brown; Bernard Moss; M Carroll; Linda S Wyatt; L Pletneva; Simoy Goldstein; D Venzon; Vanessa M Hirsch
Comparative efficacy of recombinant modified vaccinia virus Ankara expressing simian immunodeficiency virus (SIV) Gag-Pol and/or Env in macaques challenged with pathogenic SIV.
Journal of virology 2000;74(6):2740-51.
2000: Jeffrey D Lifson; Jeffrey L Rossio; RA Arnaout; L Li; Tom` Parks; Douglas K Schneider; Rebecca F Kiser; Vicky J Coalter; G Walsh; Robert J Imming; B Fisher; Bernard M Flynn; Norbert Bischofberger; Michael Piatak; Vanessa M Hirsch; Martin A Nowak; D Wodarz
Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment.
Journal of virology 2000;74(6):2584-93.
2000: Aruna Seth; Ilnour Ourmanov; Joern schmitz; Marcelo J Kuroda; Michelle A Lifton; Christine E Nickerson; Linda S Wyatt; M Carroll; Bernard Moss; D Venzon; Norman L Letvin; Vanessa M Hirsch
Immunization with a modified vaccinia virus expressing simian immunodeficiency virus (SIV) Gag-Pol primes for an anamnestic Gag-specific cytotoxic T-lymphocyte response and is associated with reduction of viremia after SIV challenge.
Journal of virology 2000;74(6):2502-9.
2000: Paul M Sharp; Elizabeth Bailes; Feng Gao; Brigitte E Beer; Vanessa M Hirsch; Beatrice H Hahn
Origins and evolution of AIDS viruses: estimating the time-scale.
Biochemical Society transactions 2000;28(2):275-82.
2000: Vanessa M Hirsch; Jeffrey D Lifson
Simian immunodeficiency virus infection of monkeys as a model system for the study of AIDS pathogenesis, treatment, and prevention.
Advances in pharmacology (San Diego, Calif.) 2000;49():437-77.
1999: Brigitte E Beer; Elizabeth Bailes; Robert M Goeken; G Dapolito; Cheick Coulibaly; Stephen Norley; Reinhard Kurth; J P Gautier; Annie Gautier-Hion; Dominique Vallet; Paul M Sharp; Vanessa M Hirsch
Simian immunodeficiency virus (SIV) from sun-tailed monkeys (Cercopithecus solatus): evidence for host-dependent evolution of SIV within the C. lhoesti superspecies.
Journal of virology 1999;73(9):7734-44.
1999: Norman L Letvin; Joern schmitz; HL Jordan; A Seth; Vanessa M Hirsch; Keith A Reimann; Marcelo J Kuroda
Cytotoxic T lymphocytes specific for the simian immunodeficiency virus.
Immunological reviews 1999;170():127-34.
1999: Vanessa M Hirsch; BJ Campbell; Elizabeth Bailes; Robert M Goeken; C Brown; WR Elkins; Michael K Axthelm; M Murphey-Corb; Paul M Sharp
Characterization of a novel simian immunodeficiency virus (SIV) from L'Hoest monkeys (Cercopithecus l'hoesti): implications for the origins of SIVmnd and other primate lentiviruses.
Journal of virology 1999;73(2):1036-45.
1999: Neal Nathanson; Vanessa M Hirsch; Bonnie J Mathieson
The role of nonhuman primates in the development of an AIDS vaccine.
AIDS (London, England) 1999;13 Suppl A():S113-20.
1998: Vanessa M Hirsch; Mark E Sharkey; Charles R Brown; B Brichacek; Simoy Goldstein; J Wakefield; Russ Byrum; WR Elkins; B H Hahn; Jeffrey D Lifson; Mario Stevenson
Vpx is required for dissemination and pathogenesis of SIV(SM) PBj: evidence of macrophage-dependent viral amplification.
Nature medicine 1998;4(12):1401-8.
1998: Aruna Seth; Ilnour Ourmanov; Marcelo J Kuroda; Joern schmitz; M W Carroll; Linda S Wyatt; Bernard Moss; MA Forman; Vanessa M Hirsch; Norman L Letvin
Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10112-6.
1998: Vanessa M Hirsch; G Dapolito; A Hahn; Jeffrey D Lifson; David Montefiori; Charles R Brown; Robert M Goeken
Viral genetic evolution in macaques infected with molecularly cloned simian immunodeficiency virus correlates with the extent of persistent viremia.
Journal of virology 1998;72(8):6482-9.
1998: Brigitte E Beer; Joachim Denner; Charles R Brown; Stephen Norley; Jan zur Megede; Cheick Coulibaly; Roland Plesker; Silke Holzammer; M Baier; Vanessa M Hirsch; Reinhard Kurth
Simian immunodeficiency virus of African green monkeys is apathogenic in the newborn natural host.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1998;18(3):210-20.
1998: K Suryanarayana; TA Wiltrout; GM Vasquez; Vanessa M Hirsch; Jeffrey D Lifson
Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction.
AIDS research and human retroviruses 1998;14(2):183-9.
1998: J Glamann; Dennis R Burton; Paul W H I Parren; Henrik J Ditzel; K A Kent; C Arnold; David Montefiori; Vanessa M Hirsch
Simian immunodeficiency virus (SIV) envelope-specific Fabs with high-level homologous neutralizing activity: recovery from a long-term-nonprogressor SIV-infected macaque.
Journal of virology 1998;72(1):585-92.
1997: Jeffrey D Lifson; Martin A Nowak; Simoy Goldstein; Jeffrey L Rossio; A Kinter; GM Vasquez; TA Wiltrout; C Brown; D Schneider; L Wahl; Alun L Lloyd; J Williams; WR Elkins; Anthony Fauci; Vanessa M Hirsch
The extent of early viral replication is a critical determinant of the natural history of simian immunodeficiency virus infection.
Journal of virology 1997;71(12):9508-14.
1997: Martin A Nowak; Alun L Lloyd; GM Vasquez; TA Wiltrout; L M Wahl; Norbert Bischofberger; J Williams; A Kinter; Anthony Fauci; Vanessa M Hirsch; Jeffrey D Lifson
Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection.
Journal of virology 1997;71(10):7518-25.
1997: BJ Campbell; Vanessa M Hirsch
Vpr of simian immunodeficiency virus of African green monkeys is required for replication in macaque macrophages and lymphocytes.
Journal of virology 1997;71(7):5593-602.
1997: Vanessa M Hirsch; D Adger-Johnson; B Campbell; S Goldstein; C Brown; W R Elkins; D C Montefiori
A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3.
Journal of virology 1997;71(2):1608-20.
1996: Vanessa M Hirsch; Thomas R Fuerst; G Sutter; MW Carroll; L C Yang; S Goldstein; M Piatak; W R Elkins; W G Alvord; D C Montefiori; Bernard Moss; Jeffrey D Lifson
Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara.
Journal of virology 1996;70(6):3741-52.
1996: Bernard Moss; MW Carroll; Linda S Wyatt; Jack R Bennink; Vanessa M Hirsch; S Goldstein; W R Elkins; Thomas R Fuerst; Jeffrey D Lifson; M Piatak; Nicholas P Restifo; Willem W Overwijk; R Chamberlain; STEVEN ROSENBERG; G Sutter
Host range restricted, non-replicating vaccinia virus vectors as vaccine candidates.
Advances in experimental medicine and biology 1996;397():7-13.
1995: Vanessa M Hirsch; G Dapolito; Robert M Goeken; B J Campbell
Phylogeny and natural history of the primate lentiviruses, SIV and HIV.
Current opinion in genetics & development 1995;5(6):798-806.
1995: Vanessa M Hirsch; G Dapolito; P R Johnson; W R Elkins; W T London; RICHARD MONTALI; S Goldstein; C Brown
Induction of AIDS by simian immunodeficiency virus from an African green monkey: species-specific variation in pathogenicity correlates with the extent of in vivo replication.
Journal of virology 1995;69(2):955-67.
1995: A Fomsgaard; P R Johnson; Claus Nielsen; Francis J Novembre; J Hansen; S Goldstein; Vanessa M Hirsch
Receptor function of CD4 structures from African green monkey and pig-tail macaque for simian immunodeficiency virus, SIVsm, SIVagm, and human immunodeficiency virus type-1.
Viral immunology 1995;8(3):121-33.
1994: R J Langley; Vanessa M Hirsch; S J O'Brien; D Adger-Johnson; Robert M Goeken; R A Olmsted
Nucleotide sequence analysis of puma lentivirus (PLV-14): genomic organization and relationship to other lentiviruses.
Virology 1994;202(2):853-64.
1994: Vanessa M Hirsch; S Goldstein; Noreen A Hynes; W R Elkins; W T London; P M Zack; D Montefiori; P R Johnson
Prolonged clinical latency and survival of macaques given a whole inactivated simian immunodeficiency virus vaccine.
The Journal of infectious diseases 1994;170(1):51-9.
1994: B J Campbell; Vanessa M Hirsch
Extensive envelope heterogeneity of simian immunodeficiency virus in tissues from infected macaques.
Journal of virology 1994;68(5):3129-37.
1994: Vanessa M Hirsch; P R Johnson
Pathogenic diversity of simian immunodeficiency viruses.
Virus research 1994;32(2):183-203.
1994: Vanessa M Hirsch; J E Martin; G Dapolito; W R Elkins; W T London; S Goldstein; P R Johnson
Spontaneous substitutions in the vicinity of the V3 analog affect cell tropism and pathogenicity of simian immunodeficiency virus.
Journal of virology 1994;68(4):2649-61.
1994: S Goldstein; W R Elkins; W T London; A Hahn; Robert M Goeken; J E Martin; Vanessa M Hirsch
Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells.
Journal of medical primatology 1994;23(2-3):75-82.
1994: Francis J Novembre; M Saucier; Vanessa M Hirsch; P R Johnson; Harold M McClure
Viral genetic determinants in SIVsmmPBj pathogenesis.
Journal of medical primatology 1994;23(2-3):136-45.
1993: Vanessa M Hirsch; C McGann; G Dapolito; S Goldstein; A Ogen-Odoi; B Biryawaho; T Lakwo; P R Johnson
Identification of a new subgroup of SIVagm in tantalus monkeys.
Virology 1993;197(1):426-30.
1993: A Fomsgaard; P R Johnson; W T London; Vanessa M Hirsch
Genetic variation of the SIVagm transmembrane glycoprotein in naturally and experimentally infected primates.
AIDS (London, England) 1993;7(8):1041-7.
1993: Noreen A Hynes; D Adger-Johnson; G Dapolito; Vanessa M Hirsch
Rapid screening for simian immunodeficiency virus variants using single-strand conformation polymorphism of PCR-amplified DNA fragments.
AIDS research and human retroviruses 1993;9(8):803-6.
1993: Francis J Novembre; P R Johnson; Mark G Lewis; Daniel Anderson; SA Klumpp; Harold M McClure; Vanessa M Hirsch
Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIVsmmPBj variant.
Journal of virology 1993;67(5):2466-74.
1993: Vanessa M Hirsch; G Dapolito; S Goldstein; Harold M McClure; P Emau; P N Fultz; M Isahakia; R Lenroot; G Myers; P R Johnson
A distinct African lentivirus from Sykes' monkeys.
Journal of virology 1993;67(3):1517-28.
1992: A Fomsgaard; Vanessa M Hirsch; P R Johnson
Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus.
European journal of immunology 1992;22(11):2973-81.
1992: Francis J Novembre; Vanessa M Hirsch; Harold M McClure; P N Fultz; P R Johnson
SIV from stump-tailed macaques: molecular characterization of a highly transmissible primate lentivirus.
Virology 1992;186(2):783-7.
1991: P R Johnson; T E Hamm; S Goldstein; S Kitov; Vanessa M Hirsch
The genetic fate of molecularly cloned simian immunodeficiency virus in experimentally infected macaques.
Virology 1991;185(1):217-28.
1991: Francis J Novembre; Vanessa M Hirsch; Harold M McClure; P R Johnson
Molecular diversity of SIVsmm/PBj and a cognate variant, SIVsmm/PGg.
Journal of medical primatology 1991;20(4):188-92.
1991: A Fomsgaard; Vanessa M Hirsch; J S Allan; P R Johnson
A highly divergent proviral DNA clone of SIV from a distinct species of African green monkey.
Virology 1991;182(1):397-402.
1991: Vanessa M Hirsch; P M Zack; A P Vogel; P R Johnson
Simian immunodeficiency virus infection of macaques: end-stage disease is characterized by widespread distribution of proviral DNA in tissues.
The Journal of infectious diseases 1991;163(5):976-88.
1990: P R Johnson; A Fomsgaard; J Allan; M Gravell; W T London; R A Olmsted; Vanessa M Hirsch
Simian immunodeficiency viruses from African green monkeys display unusual genetic diversity.
Journal of virology 1990;64(3):1086-92.
1990: A Fomsgaard; J Allan; M Gravell; W T London; Vanessa M Hirsch; P R Johnson
Molecular characterization of simian lentiviruses from east African green monkeys.
Journal of medical primatology 1990;19(3-4):295-303.
1990: Vanessa M Hirsch; P M Zack; P R Johnson
Molecular characterization of SIV in tissues from experimentally infected macaques.
Journal of medical primatology 1990;19(3-4):287-94.
1990: P R Johnson; S Goldstein; W T London; A Fomsgaard; Vanessa M Hirsch
Molecular clones of SIVsm and SIVagm: experimental infection of macaques and African green monkeys.
Journal of medical primatology 1990;19(3-4):279-86.
1989: R A Olmsted; Vanessa M Hirsch; Robert Purcell; P R Johnson
Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):8088-92.
1989: Vanessa M Hirsch; R A Olmsted; M Murphey-Corb; Robert Purcell; P R Johnson
An African primate lentivirus (SIVsm) closely related to HIV-2.
Nature 1989;339(6223):389-92.
1989: R A Olmsted; A K Barnes; J K Yamamoto; Vanessa M Hirsch; Robert Purcell; P R Johnson
Molecular cloning of feline immunodeficiency virus.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(7):2448-52.
1989: Vanessa M Hirsch; G Dapolito; C McGann; R A Olmsted; Robert Purcell; P R Johnson
Molecular cloning of SIV from sooty mangabey monkeys.
Journal of medical primatology 1989;18(3-4):279-85.
1989: P R Johnson; M Gravell; J Allan; S Goldstein; R A Olmsted; G Dapolito; C McGann; W T London; Robert Purcell; Vanessa M Hirsch
Genetic diversity among simian immunodeficiency virus isolates from African green monkeys.
Journal of medical primatology 1989;18(3-4):271-7.