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Timothy Hirst
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19
Williams, Neil
11
Nashar, Toufic
9
Lencer, Wayne
6
de Haan, Lolke
6
Freedman, Robert
5
Aman, Tholib
5
Loregian, Arianna
5
Holmes, Randall
5
Ruddock, Lloyd
5
Soriani, Marco
4
Rodighiero, Chiara
4
Salmond, Robert
4
Palù, Giorgio
4
Pitman, Richard
4
Hearn, Arron
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All Publications
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2008: Chung Wen Yuan; Sack Markus; Carter Rachel; Spiegel Holger; Fischer Rainer; Hirst Timothy R; Williams Neil A; James Roger F L
Phage-display derived single-chain fragment variable (scFv) antibodies recognizing conformational epitopes of Escherichia coli heat-labile enterotoxin B-subunit.
Journal of immunological methods 2008;339(2):115-23.
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2006: Chung Wen Yuan; Carter Rachel; Hardy Tara; Sack Markus; Hirst Timothy R; James Roger F L
Inhibition of Escherichia coli heat-labile enterotoxin B subunit pentamer (EtxB5) assembly in vitro using monoclonal antibodies.
The Journal of biological chemistry 2006;281(51):39465-70.
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2004: Hearn Arron R; de Haan Lolke; Pemberton Alexander J; Hirst Timothy R; Rivett A Jennifer
Trafficking of exogenous peptides into proteasome-dependent major histocompatibility complex class I pathway following enterotoxin B subunit-mediated delivery.
The Journal of biological chemistry 2004;279(49):51315-22.
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2004: Salmond Robert J; Williams Rachel; Hirst Timothy R; Williams Neil A
The B subunit of Escherichia coli heat-labile enterotoxin induces both caspase-dependent and -independent cell death pathways in CD8+ T cells.
Infection and immunity 2004;72(10):5850-7.
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2004: De Haan Lolke; Hirst Timothy R
Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review).
Molecular membrane biology 2004;21(2):77-92.
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2003: Salmond Robert J; Williams Rachel; Hirst Timothy R; Williams Neil A
Selective induction of CD8+CD4- thymocyte apoptosis mediated by the B-subunit of Escherichia coli heat-labile enterotoxin.
Immunology letters 2003;88(1):43-6.
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2003: Richards C M; Case R; Hirst T R; Hill T J; Williams N A
Protection against recurrent ocular herpes simplex virus type 1 disease after therapeutic vaccination of latently infected mice.
Journal of virology 2003;77(12):6692-9.
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2003: Ong Kong-Wee; Wilson A Douglas; Hirst Timothy R; Morgan Andrew J
The B subunit of Escherichia coli heat-labile enterotoxin enhances CD8+ cytotoxic-T-lymphocyte killing of Epstein-Barr virus-infected cell lines.
Journal of virology 2003;77(7):4298-305.
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2003: Fraser Sylvia A; de Haan Lolke; Hearn Arron R; Bone Heather K; Salmond Robert J; Rivett A Jennifer; Williams Neil A; Hirst Timothy R
Mutant Escherichia coli heat-labile toxin B subunit that separates toxoid-mediated signaling and immunomodulatory action from trafficking and delivery functions.
Infection and immunity 2003;71(3):1527-37.
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2002: Turcanu Victor; Hirst Timothy R; Williams Neil A
Modulation of human monocytes by Escherichia coli heat-labile enterotoxin B-subunit; altered cytokine production and its functional consequences.
Immunology 2002;106(3):316-25.
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2002: Salmond Robert J; Pitman Richard S; Jimi Eijiro; Soriani Marco; Hirst Timothy R; Ghosh Sankar; Rincón Mercedes; Williams Neil A
CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving NF-kappaB-dependent caspase activation.
European journal of immunology 2002;32(6):1737-47.
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2002: Luross Jeffrey A; Heaton Tricia; Hirst Timothy R; Day Michael J; Williams Neil A
Escherichia coli heat-labile enterotoxin B subunit prevents autoimmune arthritis through induction of regulatory CD4+ T cells.
Arthritis and rheumatism 2002;46(6):1671-82.
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2002: De Haan Lolke; Hearn Arron R; Rivett A Jennifer; Hirst Timothy R
Enhanced delivery of exogenous peptides into the class I antigen processing and presentation pathway.
Infection and immunity 2002;70(6):3249-58.
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2002: Caney S M A; Day M J; Gruffydd-Jones T J; Helps C R; Hirst T R; Stokes C R
Expression of chemokine receptors in the feline reproductive tract and large intestine.
Journal of comparative pathology 2002;126(4):289-302.
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2002: Lesieur Claire; Cliff Matthew J; Carter Rachel; James Roger F L; Clarke Anthony R; Hirst Timothy R
A kinetic model of intermediate formation during assembly of cholera toxin B-subunit pentamers.
The Journal of biological chemistry 2002;277(19):16697-704.
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2002: de Haan Lolke; Hirst Timothy R
Bacterial toxins as versatile delivery vehicles.
Current opinion in drug discovery & development 2002;5(2):269-78.
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2002: Soriani Marco; Bailey Lorna; Hirst Timothy R
Contribution of the ADP-ribosylating and receptor-binding properties of cholera-like enterotoxins in modulating cytokine secretion by human intestinal epithelial cells.
Microbiology (Reading, England) 2002;148(Pt 3):667-76.
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2002: Hirst Timothy R; Fraser Sylvia; Soriani Marco; Aman A Tholib; de Haan Lolke; Hearn Arron; Merritt Ethan
New insights into the structure-function relationships and therapeutic applications of cholera-like enterotoxins.
International journal of medical microbiology : IJMM 2002;291(6-7):531-5.
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2001: Hirst T R
Cholera. A toxin with emerging therapeutic potential.
Lancet 2001;358 Suppl():S7.
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2001: Rodighiero C; Fujinaga Y; Hirst T R; Lencer W I
A cholera toxin B-subunit variant that binds ganglioside G(M1) but fails to induce toxicity.
The Journal of biological chemistry 2001;276(40):36939-45.
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2001: Soriani M; Williams N A; Hirst T R
Escherichia coli enterotoxin B subunit triggers apoptosis of CD8(+) T cells by activating transcription factor c-myc.
Infection and immunity 2001;69(8):4923-30.
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2001: Aman A T; Fraser S; Merritt E A; Rodigherio C; Kenny M; Ahn M; Hol W G; Williams N A; Lencer W I; Hirst T R
A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8536-41.
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2001: Heyderman R S; Soriani M; Hirst T R
Is immune cell activation the missing link in the pathogenesis of post-diarrhoeal HUS?
Trends in microbiology 2001;9(6):262-6.
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2001: Millar D G; Hirst T R
Cholera toxin and Escherichia coli enterotoxin B-subunits inhibit macrophage-mediated antigen processing and presentation: evidence for antigen persistence in non-acidic recycling endosomal compartments.
Cellular microbiology 2001;3(5):311-29.
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2001: Millar D G; Hirst T R; Snider D P
Escherichia coli heat-labile enterotoxin B subunit is a more potent mucosal adjuvant than its vlosely related homologue, the B subunit of cholera toxin.
Infection and immunity 2001;69(5):3476-82.
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2001: Richards C M; Aman A T; Hirst T R; Hill T J; Williams N A
Protective mucosal immunity to ocular herpes simplex virus type 1 infection in mice by using Escherichia coli heat-labile enterotoxin B subunit as an adjuvant.
Journal of virology 2001;75(4):1664-71.
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2000: Badizadegan K; Wolf A A; Rodighiero C; Jobling M; Hirst T R; Holmes R K; Lencer W I
Floating cholera toxin into epithelial cells: functional association with caveolae-like detergent-insoluble membrane microdomains.
International journal of medical microbiology : IJMM 2000;290(4-5):403-8.
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2000: de Haan L; Hirst T R
Cholera toxin and related enterotoxins: a cell biological and immunological perspective.
Journal of natural toxins 2000;9(3):281-97.
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1999: Lencer W I; Hirst T R; Holmes R K
Membrane traffic and the cellular uptake of cholera toxin.
Biochimica et biophysica acta 1999;1450(3):177-90.
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1999: Williams N A; Hirst T R; Nashar T O
Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic.
Immunology today 1999;20(2):95-101.
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1999: Stark R M; Gerwig G J; Pitman R S; Potts L F; Williams N A; Greenman J; Weinzweig I P; Hirst T R; Millar M R
Biofilm formation by Helicobacter pylori.
Letters in applied microbiology 1999;28(2):121-6.
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1999: Rodighiero C; Aman A T; Kenny M J; Moss J; Lencer W I; Hirst T R
Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin. Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity.
The Journal of biological chemistry 1999;274(7):3962-9.
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1998: Rodighiero C; Aman A T; Lencer W I; Hirst T R
Differential activity of cholera toxin and E. coli enterotoxin: construction and purification of mutant and hybrid derivatives.
Biochemical Society transactions 1998;26(4):S364.
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1998: Pitman R S; Hirst T R; Nashar T O; Williams N A
Receptor mediated apoptosis of CD8+T cells by the B subunits of cholera-like enterotoxins.
Biochemical Society transactions 1998;26(4):S338.
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1998: Nashar T O; Williams N A; Hirst T R
Importance of receptor binding in the immunogenicity, adjuvanticity and therapeutic properties of cholera toxin and Escherichia coli heat-labile enterotoxin.
Medical microbiology and immunology 1998;187(1):3-10.
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1998: Hirst T R; Nashar T O; Pitman R S; Williams N A
Cholera toxin and related enterotoxins as potent immune modulators.
Symposium series (Society for Applied Microbiology) 1998;27():26S-34S.
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1997: Nashar T O; Hirst T R; Williams N A
Modulation of B-cell activation by the B subunit of Escherichia coli enterotoxin: receptor interaction up-regulates MHC class II, B7, CD40, CD25 and ICAM-1.
Immunology 1997;91(4):572-8.
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1997: Merritt E A; Sarfaty S; Jobling M G; Chang T; Holmes R K; Hirst T R; Hol W G
Structural studies of receptor binding by cholera toxin mutants.
Protein science : a publication of the Protein Society 1997;6(7):1516-28.
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1997: Lencer W I; Constable C; Moe S; Rufo P A; Wolf A; Jobling M G; Ruston S P; Madara J L; Holmes R K; Hirst T R
Proteolytic activation of cholera toxin and Escherichia coli labile toxin by entry into host epithelial cells. Signal transduction by a protease-resistant toxin variant.
The Journal of biological chemistry 1997;272(24):15562-8.
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1997: Williams N A; Stasiuk L M; Nashar T O; Richards C M; Lang A K; Day M J; Hirst T R
Prevention of autoimmune disease due to lymphocyte modulation by the B-subunit of Escherichia coli heat-labile enterotoxin.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5290-5.
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1996: Ruddock L W; Webb H M; Ruston S P; Cheesman C; Freedman R B; Hirst T R
A pH-dependent conformational change in the B-subunit pentamer of Escherichia coli heat-labile enterotoxin: structural basis and possible functional role for a conserved feature of the AB5 toxin family.
Biochemistry 1996;35(50):16069-76.
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1996: Loregian A; Hirst T R; Marsden H S; Palù G
Use of Vibrio spp. for expression of Escherichia coli enterotoxin B subunit fusion proteins: purification and characterization of a chimera containing a C-terminal fragment of DNA polymerase from herpes simplex virus type 1.
Protein expression and purification 1996;8(3):381-9.
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1996: Ruddock L W; Coen J J; Cheesman C; Freedman R B; Hirst T R
Assembly of the B subunit pentamer of Escherichia coli heat-labile enterotoxin. Kinetics and molecular basis of rate-limiting steps in vitro.
The Journal of biological chemistry 1996;271(32):19118-23.
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1996: Green E A; Botting C; Webb H M; Hirst T R; Randall R E
Construction, purification and immunogenicity of antigen-antibody-LTB complexes.
Vaccine 1996;14(10):949-58.
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1996: Nashar T O; Williams N A; Hirst T R;
Cross-linking of cell surface ganglioside GM1 induces the selective apoptosis of mature CD8+ T lymphocytes.
International immunology 1996;8(5):731-6.
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1996: Ruddock L W; Hirst T R; Freedman R B
pH-dependence of the dithiol-oxidizing activity of DsbA (a periplasmic protein thiol:disulphide oxidoreductase) and protein disulphide-isomerase: studies with a novel simple peptide substrate.
The Biochemical journal 1996;315 ( Pt 3)():1001-5.
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1996: Marcello A; Loregian A; De Filippis V; Fontana A; Hirst T R; Palu G
Identification and characterization of an extracellular protease activity produced by the marine Vibrio sp. 60.
FEMS microbiology letters 1996;136(1):39-44.
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1996: Nashar T O; Webb H M; Eaglestone S; Williams N A; Hirst T R
Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: receptor binding is essential and induces differential modulation of lymphocyte subsets.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):226-30.
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1995: Ruddock L W; Ruston S P; Kelly S M; Price N C; Freedman R B; Hirst T R
Kinetics of acid-mediated disassembly of the B subunit pentamer of Escherichia coli heat-labile enterotoxin. Molecular basis of pH stability.
The Journal of biological chemistry 1995;270(50):29953-8.
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1995: Hirst T R; Hillary J B; Ruddock L W; Yu J
Translocation of folded proteins across bacterial outer membranes: a novel secretory phenomenon.
Biochemical Society transactions 1995;23(4):985-91.
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1995: Lencer W I; Constable C; Moe S; Jobling M G; Webb H M; Ruston S; Madara J L; Hirst T R; Holmes R K
Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.
The Journal of cell biology 1995;131(4):951-62.
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1995: Amin T; Larkins A; James R F; Hirst T R
Generation of a monoclonal antibody that recognizes the amino-terminal decapeptide of the B-subunit of Escherichia coli heat-labile enterotoxin. A new probe for studying toxin assembly intermediates.
The Journal of biological chemistry 1995;270(34):20143-50.
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1995: Nashar T O; Hirst T R
Immunoregulatory role of H-2 and intra-H-2 alleles on antibody responses to recombinant preparations of B-subunits of Escherichia coli heat-labile enterotoxin (rEtxB) and cholera toxin (rCtxB).
Vaccine 1995;13(9):803-10.
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1995: Loregian A; Marcello A; Hirst T R; Marsden H S; Palu G
Construction of a fusion protein between B subunit of E. coli heat-labile enterotoxin and the C-terminus of herpes simplex virus-DNA polymerase.
Biochemical Society transactions 1995;23(1):61S.
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1995: Ruston S; Eaglestone S; Webb H; Hirst T R
Strategies for the purification of intact and proteolytically-activated native and engineered heat-labile enterotoxins of Escherichia coli.
Biochemical Society transactions 1995;23(1):55S.
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1995: Eaglestone S; Hirst T R
Preparation of a fusion protein for vaccination against Escherichia coli enterotoxins.
Biochemical Society transactions 1995;23(1):54S.
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1995: Yu J; Hirst T R
A pleiotropic secretion mutant of Aeromonas hydrophila is unable to secrete heterologously expressed E. coli enterotoxin: implication for common mechanisms of protein secretion.
Biochemical Society transactions 1995;23(1):34S.
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1994: Marcello A; Loregian A; Cross A; Marsden H; Hirst T R; Palù G
Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(19):8994-8.
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1994: Freedman R B; Hirst T R; Tuite M F
Protein disulphide isomerase: building bridges in protein folding.
Trends in biochemical sciences 1994;19(8):331-6.
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1994: Hirst T R; Nashar T O; Eaglestone S; Lencer W I; Webb H M; Yu J
Bacterial and host interactions during the biogenesis, toxicity and immunogenicity of Escherichia coli heat-labile enterotoxin.
Biochemical Society transactions 1994;22(2):306-9.
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1994: Amin T; Hirst T R
Purification of the B-subunit oligomer of Escherichia coli heat-labile enterotoxin by heterologous expression and secretion in a marine vibrio.
Protein expression and purification 1994;5(2):198-204.
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1994: Marcello A; Loregian A; Palù G; Hirst T R
Efficient extracellular production of hybrid E. coli heat-labile enterotoxin B subunits in a marine Vibrio.
FEMS microbiology letters 1994;117(1):47-51.
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1994: Findlay G; Hirst T R
Escherichia coli and Vibrio cholerae strains deficient in an enzyme involved in disulphide bond formation (DsbA) show an increase in sensitivity to dithiothreitol.
Biochemical Society transactions 1994;22(1):77S.
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1993: Amin T; Marcello A; Hirst T R
A new method for the purification of the B subunit (EtxB) of Escherichia coli heat-labile enterotoxin.
Biochemical Society transactions 1993;21(2):213S.
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1993: Findlay G; Yu J; Hirst T R
Analysis of enterotoxin synthesis in a Vibrio cholerae strain lacking DsbA, a periplasmic enzyme involved in disulphide bond formation.
Biochemical Society transactions 1993;21(2):212S.
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1993: Yu J; McLaughlin S; Freedman R B; Hirst T R
Cloning and active site mutagenesis of Vibrio cholerae DsbA, a periplasmic enzyme that catalyzes disulfide bond formation.
The Journal of biological chemistry 1993;268(6):4326-30.
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1993: Nashar T O; Amin T; Marcello A; Hirst T R
Current progress in the development of the B subunits of cholera toxin and Escherichia coli heat-labile enterotoxin as carriers for the oral delivery of heterologous antigens and epitopes.
Vaccine 1993;11(2):235-40.
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1992: Streatfield S J; Sandkvist M; Sixma T K; Bagdasarian M; Hol W G; Hirst T R
Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(24):12140-4.
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1992: Marcello A; Palù G; Hirst T R
E. coli heat-labile enterotoxin B subunit as a carrier for delivery of a peptide with anti-HSV activity.
Biochemical Society transactions 1992;20(4):311S.
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1992: Yu J; Webb H; Hirst T R
A homologue of the Escherichia coli DsbA protein involved in disulphide bond formation is required for enterotoxin biogenesis in Vibrio cholerae.
Molecular microbiology 1992;6(14):1949-58.
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1990: Sandkvist M; Hirst T R; Bagdasarian M
Minimal deletion of amino acids from the carboxyl terminus of the B subunit of heat-labile enterotoxin causes defects in its assembly and release from the cytoplasmic membrane of Escherichia coli.
The Journal of biological chemistry 1990;265(25):15239-44.
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1987: Sandkvist M; Hirst T R; Bagdasarian M
Alterations at the carboxyl terminus change assembly and secretion properties of the B subunit of Escherichia coli heat-labile enterotoxin.
Journal of bacteriology 1987;169(10):4570-6.
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