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John Hiscott

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Nakhaei Peyman; Mesplede Thibault; Solis Mayra; Sun Qiang; Zhao Tiejun; Yang Long; Chuang Tsung-Hsien; Ware Carl F; Lin Rongtuan; Hiscott John
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
Vitour Damien; Dabo Stéphanie; Ahmadi Pour Malek; Vilasco Myriam; Vidalain Pierre-Olivier; Jacob Yves; Mezel-Lemoine Mariana; Paz Suzanne; Arguello Meztli; Lin Rongtuan; Tangy Frédéric; Hiscott John; Meurs Eliane F
Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.
Nakhaei Peyman; Genin Pierre; Civas Ahmet; Hiscott John
RIG-I-like receptors: sensing and responding to RNA virus infection.

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All Publications

2009: Nakhaei Peyman; Mesplede Thibault; Solis Mayra; Sun Qiang; Zhao Tiejun; Yang Long; Chuang Tsung-Hsien; Ware Carl F; Lin Rongtuan; Hiscott John
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
PLoS pathogens 2009;5(11):e1000650.
2009: Vitour Damien; Dabo Stéphanie; Ahmadi Pour Malek; Vilasco Myriam; Vidalain Pierre-Olivier; Jacob Yves; Mezel-Lemoine Mariana; Paz Suzanne; Arguello Meztli; Lin Rongtuan; Tangy Frédéric; Hiscott John; Meurs Eliane F
Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.
The Journal of biological chemistry 2009;284(33):21797-809.
2009: Nakhaei Peyman; Genin Pierre; Civas Ahmet; Hiscott John
RIG-I-like receptors: sensing and responding to RNA virus infection.
Seminars in immunology 2009;21(4):215-22.
2009: Nguyen Thi Lien-Anh; Tumilasci Vanessa Fonseca; Singhroy Diane; Arguello Meztli; Hiscott John
The emergence of combinatorial strategies in the development of RNA oncolytic virus therapies.
Cellular microbiology 2009;11(6):889-97.
2009: Paz Suzanne; Vilasco Myriam; Arguello Meztli; Sun Qiang; Lacoste Judith; Nguyen Thi Lien-Anh; Zhao Tiejun; Shestakova Elena A; Zaari Scott; Bibeau-Poirier Annie; Servant Marc J; Lin Rongtuan; Meurs Eliane F; Hiscott John
Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter.
Molecular and cellular biology 2009;29(12):3401-12.
2009: Génin Pierre; Lin Rongtuan; Hiscott John; Civas Ahmet
Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7.
Molecular and cellular biology 2009;29(12):3435-50.
2009: Goubau Delphine; Romieu-Mourez Raphaëlle; Solis Mayra; Hernandez Eduardo; Mesplède Thibault; Lin Rongtuan; Leaman Douglas; Hiscott John
Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7.
European journal of immunology 2009;39(2):527-40.
2009: Yang Long; Zhao Tiejun; Shi Xiaoliu; Nakhaei Peyman; Wang Yunling; Sun Qiang; Hiscott John; Lin Rongtuan
Functional analysis of a dominant negative mutation of interferon regulatory factor 5.
PloS one 2009;4(5):e5500.
2008: Nguyên Thi Lien-Anh; Abdelbary Hesham; Arguello Meztli; Breitbach Caroline; Leveille Simon; Diallo Jean-Simon; Yasmeen Amber; Bismar Tarek A; Kirn David; Falls Theresa; Snoulten Valerie E; Vanderhyden Barbara C; Werier Joel; Atkins Harold; Vähä-Koskela Markus J V; Stojdl David F; Bell John C; Hiscott John
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14981-6.
2008: Tumilasci Vanessa Fonseca; Olière Stephanie; Nguyên Thi Lien-Ahn; Shamy April; Bell John; Hiscott John
Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis.
Journal of virology 2008;82(17):8487-99.
2008: Oliere Stephanie; Arguello Meztli; Mesplede Thibault; Tumilasci Vanessa; Nakhaei Peyman; Stojdl David; Sonenberg Nahum; Bell John; Hiscott John
Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation.
Journal of virology 2008;82(12):5735-49.
2008: Escors David; Lopes Luciene; Lin Rongtuan; Hiscott John; Akira Shizuo; Davis Roger J; Collins Mary K
Targeting dendritic cell signaling to regulate the response to immunization.
Blood 2008;111(6):3050-61.
2007: Arguello Meztli D; Hiscott John
Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates.
Cell host & microbe 2007;2(6):367-9.
2007: Solis Mayra; Goubau Delphine; Hiscott John
RIG-I has guts: identification of a role for RIG-I in colitis development.
Cell research 2007;17(12):974-5.
2007: Lezin Agnès; Gillet Nicolas; Olindo Stéphane; Signaté Aïssatou; Grandvaux Nathalie; Verlaeten Olivier; Belrose Gildas; de Carvalho Bittencourt Marcelo; Hiscott John; Asquith Becca; Burny Arsène; Smadja Didier; Césaire Raymond; Willems Luc
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients.
Blood 2007;110(10):3722-8.
2007: Hiscott John
Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response.
Cytokine & growth factor reviews 2007;18(5-6):483-90.
2007: Lemay Guy; Tumilasci Vanessa; Hiscott John
Uncoating reo: uncovering the steps critical for oncolysis.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(8):1406-7.
2007: Sharif-Askari Ehssan; Nakhaei Peyman; Oliere Stephanie; Tumilasci Vanessa; Hernandez Eduardo; Wilkinson Peter; Lin Rongtuan; Bell John; Hiscott John
Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection.
Virology 2007;365(1):20-33.
2007: Zhao Tiejun; Yang Long; Sun Qiang; Arguello Meztli; Ballard Dean W; Hiscott John; Lin Rongtuan
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
Nature immunology 2007;8(6):592-600.
2007: Hiscott John
Triggering the innate antiviral response through IRF-3 activation.
The Journal of biological chemistry 2007;282(21):15325-9.
2007: Solis Mayra; Romieu-Mourez Raphaëlle; Goubau Delphine; Grandvaux Nathalie; Mesplede Thibault; Julkunen Ilkka; Nardin Alessandra; Salcedo Margarita; Hiscott John
Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages.
European journal of immunology 2007;37(2):528-39.
2006: Romieu-Mourez Raphaëlle; Solis Mayra; Nardin Alessandra; Goubau Delphine; Baron-Bodo Véronique; Lin Rongtuan; Massie Bernard; Salcedo Margarita; Hiscott John
Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages.
Cancer research 2006;66(21):10576-85.
2006: Hiscott John; Lacoste Judith; Lin Rongtuan
Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease.
Biochemical pharmacology 2006;72(11):1477-84.
2006: Solis Mayra; Goubau Delphine; Romieu-Mourez Raphaëlle; Genin Pierre; Civas Ahmet; Hiscott John
Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.
Biochemical pharmacology 2006;72(11):1469-76.
2006: Hiscott J; Nguyen T-L A; Arguello M; Nakhaei P; Paz S
Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses.
Oncogene 2006;25(51):6844-67.
2006: Bibeau-Poirier Annie; Gravel Simon-Pierre; Clément Jean-François; Rolland Sébastien; Rodier Geneviève; Coulombe Philippe; Hiscott John; Grandvaux Nathalie; Meloche Sylvain; Servant Marc J
Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5059-67.
2006: Harris Jennifer; Olière Stéphanie; Sharma Sonia; Sun Qiang; Lin Rongtuan; Hiscott John; Grandvaux Nathalie
Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2527-35.
2006: Solis Mayra; Wilkinson Peter; Romieu Raphaelle; Hernandez Eduardo; Wainberg Mark A; Hiscott John
Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells.
Virology 2006;352(1):86-99.
2006: Lin Rongtuan; Lacoste Judith; Nakhaei Peyman; Sun Qiang; Yang Long; Paz Suzanne; Wilkinson Peter; Julkunen Ilkka; Vitour Damien; Meurs Eliane; Hiscott John
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.
Journal of virology 2006;80(12):6072-83.
2006: Arguello Meztli; Paz Suzanne; Hernandez Eduardo; Corriveau-Bourque Catherine; Fawaz Lama M; Hiscott John; Lin Rongtuan
Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7051-61.
2006: Hiscott John; Lin Rongtuan; Nakhaei Peyman; Paz Suzanne
MasterCARD: a priceless link to innate immunity.
Trends in molecular medicine 2006;12(2):53-6.
2006: Civas Ahmet; Génin Pierre; Morin Pierre; Lin Rongtuan; Hiscott John
Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.
The Journal of biological chemistry 2006;281(8):4856-66.
2006: Bannwarth Sylvie; Lainé Sébastien; Daher Aïcha; Grandvaux Nathalie; Clerzius Guerline; Leblanc Andréa C; Hiscott John; Gatignol Anne
Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes.
Journal of molecular biology 2006;355(5):898-910.
2006: Lin Rongtuan; Yang Long; Nakhaei Peyman; Sun Qiang; Sharif-Askari Ehssan; Julkunen Ilkka; Hiscott John
Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.
The Journal of biological chemistry 2006;281(4):2095-103.
2006: Césaire R; Olière S; Sharif-Askari E; Loignon M; Lézin A; Olindo S; Panelatti G; Kazanji M; Aloyz R; Panasci L; Bell J C; Hiscott J
Oncolytic activity of vesicular stomatitis virus in primary adult T-cell leukemia.
Oncogene 2006;25(3):349-58.
2006: Paz S; Sun Q; Nakhaei P; Romieu-Mourez R; Goubau D; Julkunen I; Lin R; Hiscott J
Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(1):17-28.
2005: Pickell Laura; Tran Pamela; Leclerc Daniel; Hiscott John; Rozen Rima
Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity.
Biochimica et biophysica acta 2005;1731(2):104-14.
2005: Desfosses Yan; Solis Mayra; Sun Qiang; Grandvaux Nathalie; Van Lint Carine; Burny Arsene; Gatignol Anne; Wainberg Mark A; Lin Rongtuan; Hiscott John
Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.
Journal of virology 2005;79(14):9180-91.
2005: Grandvaux Nathalie; Gaboriau François; Harris Jennifer; tenOever Benjamin R; Lin Rongtuan; Hiscott John
Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response.
The FEBS journal 2005;272(12):3120-31.
2005: Breiman Adrien; Grandvaux Nathalie; Lin Rongtuan; Ottone Catherine; Akira Shizuo; Yoneyama Mitsutoshi; Fujita Takashi; Hiscott John; Meurs Eliane F
Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.
Journal of virology 2005;79(7):3969-78.
2005: Mamane Yaël; Loignon Martin; Palmer Jennifer; Hernandez Eduardo; Césaire Raymond; Alaoui-Jamali Moulay; Hiscott John
Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005;25(1):43-51.
2005: Lin Rongtuan; Yang Long; Arguello Meztli; Penafuerte Claudia; Hiscott John
A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.
The Journal of biological chemistry 2005;280(4):3088-95.
2004: tenOever Benjamin R; Sharma Sonia; Zou Wen; Sun Qiang; Grandvaux Nathalie; Julkunen Ilkka; Hemmi Hiroaki; Yamamoto M; Akira Shizuo; Yeh Wen-Chen; Lin Rongtuan; Hiscott John
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
Journal of virology 2004;78(19):10636-49.
2004: Miller Kristen; McArdle Susan; Gale Michael J; Geller David A; Tenoever Benjamin; Hiscott John; Gretch David R; Polyak Stephen J
Effects of the hepatitis C virus core protein on innate cellular defense pathways.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004;24(7):391-402.
2004: Sgarbanti Marco; Arguello Meztli; tenOever Benjamin R; Battistini Angela; Lin Rongtuan; Hiscott John
A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions.
Oncogene 2004;23(34):5770-80.
2003: Hiscott John; Grandvaux Nathalie; Sharma Sonia; Tenoever Benjamin R; Servant Marc J; Lin Rongtuan
Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis.
Annals of the New York Academy of Sciences 2003;1010():237-48.
2003: Stojdl David F; Lichty Brian D; tenOever Benjamin R; Paterson Jennifer M; Power Anthony T; Knowles Shane; Marius Ricardo; Reynard Jennifer; Poliquin Laurent; Atkins Harold; Brown Earl G; Durbin Russell K; Durbin Joan E; Hiscott John; Bell John C
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents.
Cancer cell 2003;4(4):263-75.
2003: Battisti Pier-Luigi; Daher Aïcha; Bannwarth Sylvie; Voortman Johannes; Peden Keith W C; Hiscott John; Mouland Andrew J; Benarous Richard; Gatignol Anne
Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells.
AIDS research and human retroviruses 2003;19(9):767-78.
2003: Sharma Sonia; tenOever Benjamin R; Grandvaux Nathalie; Zhou Guo-Ping; Lin Rongtuan; Hiscott John
Triggering the interferon antiviral response through an IKK-related pathway.
Science (New York, N.Y.) 2003;300(5622):1148-51.
2003: Servant Marc J; Grandvaux Nathalie; tenOever Benjamin R; Duguay Delphine; Lin Rongtuan; Hiscott John
Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.
The Journal of biological chemistry 2003;278(11):9441-7.
2003: Arguello Meztli; Sgarbanti Marco; Hernandez Eduardo; Mamane Yael; Sharma Sonia; Servant Marc; Lin Rongtuan; Hiscott John
Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines.
Oncogene 2003;22(7):964-73.
2002: Mamane Yaël; Grandvaux Nathalie; Hernandez Eduardo; Sharma Sonia; Innocente Steve A; Lee Jonathan M; Azimi Nazli; Lin Rongtuan; Hiscott John
Repression of IRF-4 target genes in human T cell leukemia virus-1 infection.
Oncogene 2002;21(44):6751-65.
2002: Duguay Delphine; Mercier François; Stagg John; Martineau Daniel; Bramson Jonathan; Servant Marc; Lin Rongtuan; Galipeau Jacques; Hiscott John
In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors.
Cancer research 2002;62(18):5148-52.
2002: Sharma Sonia; Grandvaux Nathalie; Mamane Yael; Genin Pierre; Azimi Nazli; Waldmann Thomas; Hiscott John
Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3120-30.
2002: Servant Marc J; Grandvaux Nathalie; Hiscott John
Multiple signaling pathways leading to the activation of interferon regulatory factor 3.
Biochemical pharmacology 2002;64(5-6):985-92.
2002: Baetu Tudor M; Hiscott John
On the TRAIL to apoptosis.
Cytokine & growth factor reviews 2002;13(3):199-207.
2002: Mariner Jennifer M; Mamane Yael; Hiscott John; Waldmann Thomas A; Azimi Nazli
IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5667-74.
2002: Grandvaux Nathalie; tenOever Benjamin R; Servant Marc J; Hiscott John
The interferon antiviral response: from viral invasion to evasion.
Current opinion in infectious diseases 2002;15(3):259-67.
2002: Grandvaux Nathalie; Servant Marc J; tenOever Benjamin; Sen Ganes C; Balachandran Siddarth; Barber Glen N; Lin Rongtuan; Hiscott John
Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes.
Journal of virology 2002;76(11):5532-9.
2002: Roof Philippe; Ricci Maria; Genin Pierre; Montano Monty A; Essex Max; Wainberg Mark A; Gatignol Anne; Hiscott John
Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator.
Virology 2002;296(1):77-83.
2002: tenOever Benjamin R; Servant Marc J; Grandvaux Nathalie; Lin Rongtuan; Hiscott John
Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation.
Journal of virology 2002;76(8):3659-69.
2002: Morin Pierre; Bragança José; Bandu Marie-Thérèse; Lin Rongtuan; Hiscott John; Doly Janine; Civas Ahmet
Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription.
Journal of molecular biology 2002;316(5):1009-22.
2002: Mamane Yael; Sharma Sonia; Grandvaux Nathalie; Hernandez Eduardo; Hiscott John
IRF-4 activities in HTLV-I-induced T cell leukemogenesis.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(1):135-43.
2002: Battistini A; Marsili G; Sgarbanti M; Ensoli B; Hiscott J
IRF regulation of HIV-1 long terminal repeat activity.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(1):27-37.
2001: Coccia E M; Stellacci E; Valtieri M; Masella B; Feccia T; Marziali G; Hiscott J; Testa U; Peschle C; Battistini A
Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation.
The Biochemical journal 2001;360(Pt 2):285-94.
2001: Bannwarth S; Talakoub L; Letourneur F; Duarte M; Purcell D F; Hiscott J; Gatignol A
Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line.
The Journal of biological chemistry 2001;276(52):48803-13.
2001: Baetu T M; Kwon H; Sharma S; Grandvaux N; Hiscott J
Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3164-73.
2001: Le Page C; Popescu O; Génin P; Lian J; Paquin A; Galipeau J; Hiscott J
Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants.
Virology 2001;286(2):422-33.
2001: Ishii T; Kwon H; Hiscott J; Mosialos G; Koromilas A E
Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.
Oncogene 2001;20(15):1900-12.
2001: Lin R; Genin P; Mamane Y; Sgarbanti M; Battistini A; Harrington W J; Barber G N; Hiscott J
HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators.
Oncogene 2001;20(7):800-11.
2001: Hiscott J; Kwon H; Génin P
Hostile takeovers: viral appropriation of the NF-kappaB pathway.
The Journal of clinical investigation 2001;107(2):143-51.
2001: Servant M J; ten Oever B; LePage C; Conti L; Gessani S; Julkunen I; Lin R; Hiscott J
Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3.
The Journal of biological chemistry 2001;276(1):355-63.
2000: Sharma S; Mamane Y; Grandvaux N; Bartlett J; Petropoulos L; Lin R; Hiscott J
Activation and regulation of interferon regulatory factor 4 in HTLV type 1-infected T lymphocytes.
AIDS research and human retroviruses 2000;16(16):1613-22.
2000: Lin R; Mamane Y; Hiscott J
Multiple regulatory domains control IRF-7 activity in response to virus infection.
The Journal of biological chemistry 2000;275(44):34320-7.
2000: Lin R; Génin P; Mamane Y; Hiscott J
Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7.
Molecular and cellular biology 2000;20(17):6342-53.
2000: Génin P; Algarté M; Roof P; Lin R; Hiscott J
Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5352-61.
2000: Heylbroeck C; Balachandran S; Servant M J; DeLuca C; Barber G N; Lin R; Hiscott J
The IRF-3 transcription factor mediates Sendai virus-induced apoptosis.
Journal of virology 2000;74(8):3781-92.
2000: Mamane Y; Sharma S; Petropoulos L; Lin R; Hiscott J
Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52.
Immunity 2000;12(2):129-40.
2000: Le Page C; Génin P; Baines M G; Hiscott J
Interferon activation and innate immunity.
Reviews in immunogenetics 2000;2(3):374-86.
1999: DeLuca C; Kwon H; Lin R; Wainberg M; Hiscott J
NF-kappaB activation and HIV-1 induced apoptosis.
Cytokine & growth factor reviews 1999;10(3-4):235-53.
1999: Mamane Y; Heylbroeck C; Génin P; Algarté M; Servant M J; LePage C; DeLuca C; Kwon H; Lin R; Hiscott J
Interferon regulatory factors: the next generation.
Gene 1999;237(1):1-14.
1999: Nguyen H; Teskey L; Lin R; Hiscott J
Identification of the secretory leukocyte protease inhibitor (SLPI) as a target of IRF-1 regulation.
Oncogene 1999;18(39):5455-63.
1999: Génin P; Mamane Y; Kwon H; LePage C; Wainberg M A; Hiscott J
Differential regulation of CC chemokine gene expression in human immunodeficiency virus-infected myeloid cells.
Virology 1999;261(2):205-15.
1999: Algarté M; Kwon H; Génin P; Hiscott J
Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter.
Molecular and cellular biology 1999;19(9):6140-53.
1999: DeLuca C; Petropoulos L; Zmeureanu D; Hiscott J
Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells.
The Journal of biological chemistry 1999;274(19):13010-6.
1999: Lin R; Mamane Y; Hiscott J
Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains.
Molecular and cellular biology 1999;19(4):2465-74.
1999: Algarté M; Nguyen H; Heylbroeck C; Lin R; Hiscott J
IkappaB-mediated inhibition of virus-induced beta interferon transcription.
Journal of virology 1999;73(4):2694-702.
1999: Coccia E M; Del Russo N; Stellacci E; Orsatti R; Benedetti E; Marziali G; Hiscott J; Battistini A
Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2.
Oncogene 1999;18(12):2129-37.
1999: Lin R; Heylbroeck C; Genin P; Pitha P M; Hiscott J
Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.
Molecular and cellular biology 1999;19(2):959-66.
1999: Lin R; Hiscott J
A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity.
Molecular and cellular biochemistry 1999;191(1-2):169-80.
1999: Hiscott J; Pitha P; Genin P; Nguyen H; Heylbroeck C; Mamane Y; Algarte M; Lin R
Triggering the interferon response: the role of IRF-3 transcription factor.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(1):1-13.
1999: Spencer W; Kwon H; Crépieux P; Leclerc N; Lin R; Hiscott J
Taxol selectively blocks microtubule dependent NF-kappaB activation by phorbol ester via inhibition of IkappaBalpha phosphorylation and degradation.
Oncogene 1999;18(2):495-505.
1998: Petropoulos L; Hiscott J
Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state.
Virology 1998;252(1):189-99.
1998: Lin R; Heylbroeck C; Pitha P M; Hiscott J
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.
Molecular and cellular biology 1998;18(5):2986-96.
1998: DeLuca C; Kwon H; Pelletier N; Wainberg M A; Hiscott J
NF-kappaB protects HIV-1-infected myeloid cells from apoptosis.
Virology 1998;244(1):27-38.
1998: Dehbi M; Hiscott J; Pelletier J
Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB.
Oncogene 1998;16(16):2033-9.
1998: Kwon H; Pelletier N; DeLuca C; Genin P; Cisternas S; Lin R; Wainberg M A; Hiscott J
Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells.
The Journal of biological chemistry 1998;273(13):7431-40.
1997: Nguyen H; Hiscott J; Pitha P M
The growing family of interferon regulatory factors.
Cytokine & growth factor reviews 1997;8(4):293-312.
1997: Crépieux P; Kwon H; Leclerc N; Spencer W; Richard S; Lin R; Hiscott J
I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain.
Molecular and cellular biology 1997;17(12):7375-85.
1997: Nguyen H; Lin R; Hiscott J
Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins.
Oncogene 1997;15(12):1425-35.
1997: Liang C; Li X; Quan Y; Laughrea M; Kleiman L; Hiscott J; Wainberg M A
Sequence elements downstream of the human immunodeficiency virus type 1 long terminal repeat are required for efficient viral gene transcription.
Journal of molecular biology 1997;272(2):167-77.
1997: Lee R; Beauparlant P; Elford H; Ponka P; Hiscott J
Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds.
Virology 1997;234(2):277-90.
1997: Hiscott J; Beauparlant P; Crepieux P; DeLuca C; Kwon H; Lin R; Petropoulos L
Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.
Journal of leukocyte biology 1997;62(1):82-92.
1997: Conti L; Hiscott J; Papacchini M; Roulston A; Wainberg M A; Belardelli F; Gessani S
Induction of relA(p65) and I kappa B alpha subunit expression during differentiation of human peripheral blood monocytes to macrophages.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(4):435-42.
1997: Nagai K; Wong A H; Li S; Tam W N; Cuddihy A R; Sonenberg N; Mathews M B; Hiscott J; Wainberg M A; Koromilas A E
Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR.
Journal of virology 1997;71(2):1718-25.
1996: Petropoulos L; Lin R; Hiscott J
Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein.
Virology 1996;225(1):52-64.
1996: Beauparlant P; Kwon H; Clarke M; Lin R; Sonenberg N; Wainberg M; Hiscott J
Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication.
Journal of virology 1996;70(9):5777-85.
1996: Beauparlant P; Hiscott J
Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis.
Cytokine & growth factor reviews 1996;7(2):175-90.
1996: DeLuca C; Roulston A; Koromilas A; Wainberg M A; Hiscott J
Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation.
Journal of virology 1996;70(8):5183-93.
1996: Beauparlant P; Lin R; Hiscott J
The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization.
The Journal of biological chemistry 1996;271(18):10690-6.
1996: Lin R; Beauparlant P; Makris C; Meloche S; Hiscott J
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.
Molecular and cellular biology 1996;16(4):1401-9.
1995: Hiscott J; Petropoulos L; Lacoste J
Molecular interactions between HTLV-1 Tax protein and the NF-kappa B/kappa B transcription complex.
Virology 1995;214(1):3-11.
1995: Koromilas A E; Cantin C; Craig A W; Jagus R; Hiscott J; Sonenberg N
The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.
The Journal of biological chemistry 1995;270(43):25426-34.
1995: Roulston A; Lin R; Beauparlant P; Wainberg M A; Hiscott J
Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.
Microbiological reviews 1995;59(3):481-505.
1995: Bitar R; Beauparlant P; Lin R; Pitha P; Hiscott J
Retrovirus-mediated transfer of nuclear factor-kappa B subunit genes modulates I kappa B alpha and interferon beta expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(8):965-76.
1995: Nguyen H; Mustafa A; Hiscott J; Lin R
Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain.
Oncogene 1995;11(3):537-44.
1995: Lin R; Gewert D; Hiscott J
Differential transcriptional activation in vitro by NF-kappa B/Rel proteins.
The Journal of biological chemistry 1995;270(7):3123-31.
1995: Lacoste J; Petropoulos L; Pépin N; Hiscott J
Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells.
Journal of virology 1995;69(1):564-9.
1994: Pepin N; Roulston A; Lacoste J; Lin R; Hiscott J
Subcellular redistribution of HTLV-1 Tax protein by NF-kappa B/Rel transcription factors.
Virology 1994;204(2):706-16.
1994: Beauparlant P; Kwan I; Bitar R; Chou P; Koromilas A E; Sonenberg N; Hiscott J
Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation.
Oncogene 1994;9(11):3189-97.
1994: Garoufalis E; Kwan I; Lin R; Mustafa A; Pepin N; Roulston A; Lacoste J; Hiscott J
Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors.
Journal of virology 1994;68(8):4707-15.
1994: Lin R; Mustafa A; Nguyen H; Gewert D; Hiscott J
Mutational analysis of interferon (IFN) regulatory factors 1 and 2. Effects on the induction of IFN-beta gene expression.
The Journal of biological chemistry 1994;269(26):17542-9.
1994: Lacoste J; Lanoix J; Pepin N; Hiscott J
Interactions between HTLV-I Tax and NF-kappa B/Rel proteins in T cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8 Suppl 1():S71-6.
1994: Roulston A; Conti L; McKiel V; Wainberg M A; Hiscott J
Virus induction of NF-kappa B/Rel proteins and type I interferon gene expression in myelomonoblastic cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8 Suppl 1():S170-4.
1994: Lanoix J; Lacoste J; Pepin N; Rice N; Hiscott J
Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway.
Oncogene 1994;9(3):841-52.
1993: Hiscott J; Marois J; Garoufalis J; D'Addario M; Roulston A; Kwan I; Pepin N; Lacoste J; Nguyen H; Bensi G
Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.
Molecular and cellular biology 1993;13(10):6231-40.
1993: Roulston A; Beauparlant P; Rice N; Hiscott J
Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells.
Journal of virology 1993;67(9):5235-46.
1993: Soudeyns H; Geleziunas R; Shyamala G; Hiscott J; Wainberg M A
Identification of a novel glucocorticoid response element within the genome of the human immunodeficiency virus type 1.
Virology 1993;194(2):758-68.
1992: Cohen L; Hiscott J
Characterization of TH3, an induction-specific protein interacting with the interferon beta promoter.
Virology 1992;191(2):589-99.
1992: Cohen L; Hiscott J
Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins.
Journal of cellular physiology 1992;152(1):10-8.
1992: Gosselin J; Flamand L; D'Addario M; Hiscott J; Stefanescu I; Ablashi D V; Gallo R C; Menezes J
Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):181-7.
1992: Gosselin J; Flamand L; D'Addario M; Hiscott J; Menezes J
Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha.
The Journal of clinical investigation 1992;89(6):1849-56.
1992: Roulston A; D'Addario M; Boulerice F; Caplan S; Wainberg M A; Hiscott J
Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells.
The Journal of experimental medicine 1992;175(3):751-63.
1992: Boulerice F; Geleziunas R; Bour S; Li H L; D'Addario M; Roulston A; Hiscott J; Wainberg M A
Differential susceptibilities of U-937 cell clones to infection by human immunodeficiency virus type 1.
Journal of virology 1992;66(2):1183-7.
1992: D'Addario M; Wainberg M A; Hiscott J
Activation of cytokine genes in HIV-1 infected myelomonoblastic cells by phorbol ester and tumor necrosis factor.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):1222-9.
1992: Leblanc J F; Hiscott J
Differential response of human interferon-beta promoter elements to trans-activation by HSV VP16 and IRF-1.
Virology 1992;186(2):760-3.
1991: Lacoste J; Cohen L; Hiscott J
NF-kappa B activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I.
Virology 1991;184(2):553-62.
1991: Flamand L; Gosselin J; D'Addario M; Hiscott J; Ablashi D V; Gallo R C; Menezes J
Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures.
Journal of virology 1991;65(9):5105-10.
1991: Cohen L; Lacoste J; Parniak M; Daigneault L; Skup D; Hiscott J
Stimulation of interferon beta gene transcription in vitro by purified NF-kappa B and a novel TH protein.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(7):323-33.
1991: Geleziunas R; McQuillan A; Malapetsa A; Hutchinson M; Kopriva D; Wainberg M A; Hiscott J; Bramson J; Panasci L
Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards.
Journal of the National Cancer Institute 1991;83(8):557-64.
1991: Geleziunas R; Bour S; Boulerice F; Hiscott J; Wainberg M A
Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1.
AIDS (London, England) 1991;5(1):29-33.
1991: Gosselin J; Menezes J; D'Addario M; Hiscott J; Flamand L; Lamoureux G; Oth D
Inhibition of tumor necrosis factor-alpha transcription by Epstein-Barr virus.
European journal of immunology 1991;21(1):203-8.
1990: D'Addario M; Roulston A; Wainberg M A; Hiscott J
Coordinate enhancement of cytokine gene expression in human immunodeficiency virus type 1-infected promonocytic cells.
Journal of virology 1990;64(12):6080-9.
1990: Dubreuil M; Sportza L; D'Addario M; Lacoste J; Rooke R; Wainberg M A; Hiscott J
Inhibition of HIV-1 transmission by interferon and 3'-azido-3'-deoxythymidine during de novo infection of promonocytic cells.
Virology 1990;179(1):388-94.
1990: Tremblay M; Numazaki K; Li X G; Gornitsky M; Hiscott J; Wainberg M A
Resistance to infection by HIV-1 of peripheral blood mononuclear cells from HIV-1-infected patients is probably mediated by neutralizing antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(9):2896-901.
1990: Lacoste J; D'Addario M; Roulston A; Wainberg M A; Hiscott J
Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor.
Journal of virology 1990;64(10):4726-34.
1990: Leblanc J F; Cohen L; Rodrigues M; Hiscott J
Synergism between distinct enhanson domains in viral induction of the human beta interferon gene.
Molecular and cellular biology 1990;10(8):3987-93.
1990: Xanthoudakis S; Hiscott J
UV cross-linking of distinct proteins to the PRDII domain of the interferon-beta promoter.
Biochemical and biophysical research communications 1990;167(3):1086-93.
1989: Hiscott J; Alper D; Cohen L; Leblanc J F; Sportza L; Wong A; Xanthoudakis S
Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer.
Journal of virology 1989;63(6):2557-66.
1989: Xanthoudakis S; Cohen L; Hiscott J
Multiple protein-DNA interactions within the human interferon-beta regulatory element.
The Journal of biological chemistry 1989;264(2):1139-45.
1988: Xanthoudakis S; Hiscott J
Modulation of interferon gene transcription by positive and negative cellular factors.
Biochemical and biophysical research communications 1988;154(3):1338-44.
1988: Hiscott J; Wong A; Alper D; Xanthoudakis S
trans activation of type 1 interferon promoters by simian virus 40 T antigen.
Molecular and cellular biology 1988;8(8):3397-405.
1988: Marshall A H; Alper D; Hiscott J
Modulation of nuclear proto-oncogene expression and cellular growth in myeloid leukemic cells by human interferon alpha.
Journal of cellular physiology 1988;135(2):324-31.
1987: Xanthoudakis S; Alper D; Hiscott J
Transient expression of the beta interferon promoter in human cells.
Molecular and cellular biology 1987;7(10):3830-5.
1987: Xanthoudakis S; Hiscott J
Identification of a nuclear DNA binding protein associated with the interferon-beta upstream regulatory region.
The Journal of biological chemistry 1987;262(17):8298-302.

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