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John Hiscott

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Marie-Line Goulet; Elias K Haddad; Meztli Arguello; Siddharth Balachandran; S Mehdi Belgnaoui; Mark Cameron; Khader Ghneim; Valérie Janelle; Ulrich Kalinke; Erin I Lafferty; Alain Lamarre; Rongtuan Lin; David Olagnier; Marilene Paquet; Suzanne Paz; Suraj Peri; Salman Qureshi; Stephanie Richards; Rafick-Pierre Sekaly; Andrew Smith; Peter Wilkinson; Zhengyun Xu; John Hiscott
Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity.
S Mehdi Belgnaoui; Ivan Dikic; Marie-Line Goulet; John Hiscott; Kazuhiro Iwai; Marjolein Kikkert; Suzanne Paz; Sara Samuel; Qiang Sun; Rongtuan Lin
Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex.
Pierre Génin; John Hiscott; Rongtuan Lin; Ahmet Civas
Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression.

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All Publications

2013: Marie-Line Goulet; Elias K Haddad; Meztli Arguello; Siddharth Balachandran; S Mehdi Belgnaoui; Mark Cameron; Khader Ghneim; Valérie Janelle; Ulrich Kalinke; Erin I Lafferty; Alain Lamarre; Rongtuan Lin; David Olagnier; Marilene Paquet; Suzanne Paz; Suraj Peri; Salman Qureshi; Stephanie Richards; Rafick-Pierre Sekaly; Andrew Smith; Peter Wilkinson; Zhengyun Xu; John Hiscott
Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity.
PLoS pathogens 2013;9(4):e1003298.
2012: S Mehdi Belgnaoui; Ivan Dikic; Marie-Line Goulet; John Hiscott; Kazuhiro Iwai; Marjolein Kikkert; Suzanne Paz; Sara Samuel; Qiang Sun; Rongtuan Lin
Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex.
Cell host & microbe 2012;12(2):211-22.
2012: Pierre Génin; John Hiscott; Rongtuan Lin; Ahmet Civas
Recruitment of histone deacetylase 3 to the interferon-A gene promoters attenuates interferon expression.
PloS one 2012;7(6):e38336.
2011: S Mehdi Belgnaoui; Suzanne Paz; John Hiscott
Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter.
Current opinion in immunology 2011;23(5):564-72.
2011: Stéphanie Olière; Alexandre Sze; S Mehdi Belgnaoui; Renée Douville; John Hiscott
Modulation of innate immune responses during human T-cell leukemia virus (HTLV-1) pathogenesis.
Cytokine & growth factor reviews 2011;22(4):197-210.
2011: Suzanne Paz; Myriam Vilasco; Steven J Werden; Meztli Arguello; Deshanthe Joseph-Pillai; Tiejun Zhao; Thi Lien-Anh Nguyen; Qiang Sun; Eliane F Meurs; Rongtuan Lin; John Hiscott
A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response.
Cell research 2011;21(6):895-910.
2011: Mayra Solis; Peyman Nakhaei; Mohammad Jalalirad; Judith Lacoste; Renée Douville; Meztli Arguello; Tiejun Zhao; Michael Laughrea; Mark A Wainberg; John Hiscott
RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I.
Journal of virology 2011;85(3):1224-36.
2010: Suzanne Paz; John Hiscott
CuRTAiling interferon regulatory factor signaling with the E3 ligase RAUL.
Immunity 2010;33(6):833-5.
2010: Renée N Douville; John Hiscott
The interface between the innate interferon response and expression of host retroviral restriction factors.
Cytokine 2010;52(1-2):108-15.
2010: Peyman Nakhaei; John Hiscott; Rongtuan Lin
STING-ing the antiviral pathway.
Journal of molecular cell biology 2010;2(3):110-2.
2010: Thi Lien-Anh Nguyen; Marnie Goodwin Wilson; John Hiscott
Oncolytic viruses and histone deacetylase inhibitors--a multi-pronged strategy to target tumor cells.
Cytokine & growth factor reviews 2010;21(2-3):153-9.
2010: Stéphanie Olière; Eduardo Hernandez; Agnès Lézin; Meztli Arguello; Renée Douville; Thi Lien-Anh Nguyen; Stéphane Olindo; Gérard Panelatti; Mirdad Kazanji; Peter Wilkinson; Rafick-Pierre Sékaly; Raymond Césaire; John Hiscott
HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1).
PLoS pathogens 2010;6(11):e1001177.
2009: Peyman Nakhaei; Thibault Mesplede; Mayra Solis; Qiang Sun; Tiejun Zhao; Long Yang; Tsung-Hsien Chuang; Carl F Ware; Rongtuan Lin; John Hiscott
The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.
PLoS pathogens 2009;5(11):e1000650.
2009: Damien Vitour; Stéphanie Dabo; Malek Ahmadi Pour; Myriam Vilasco; Pierre-Olivier Vidalain; Yves Jacob; Mariana Mezel-Lemoine; Suzanne Paz; Meztli Arguello; Rongtuan Lin; Frédéric Tangy; John Hiscott; Eliane F Meurs
Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS.
The Journal of biological chemistry 2009;284(33):21797-809.
2009: Peyman Nakhaei; Pierre Genin; Ahmet Civas; John Hiscott
RIG-I-like receptors: sensing and responding to RNA virus infection.
Seminars in immunology 2009;21(4):215-22.
2009: Thi Lien-Anh Nguyen; Vanessa Fonseca Tumilasci; Diane Singhroy; Meztli Arguello; John Hiscott
The emergence of combinatorial strategies in the development of RNA oncolytic virus therapies.
Cellular microbiology 2009;11(6):889-97.
2009: Suzanne Paz; Myriam Vilasco; Meztli Arguello; Qiang Sun; Judith Lacoste; Thi Lien-Anh Nguyen; Tiejun Zhao; Elena A Shestakova; Scott Zaari; Annie Bibeau-Poirier; Marc J Servant; Rongtuan Lin; Eliane F Meurs; John Hiscott
Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter.
Molecular and cellular biology 2009;29(12):3401-12.
2009: Pierre Génin; Rongtuan Lin; John Hiscott; Ahmet Civas
Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7.
Molecular and cellular biology 2009;29(12):3435-50.
2009: Delphine Goubau; Raphaëlle Romieu-Mourez; Mayra Solis; Eduardo Hernandez; Thibault Mesplède; Rongtuan Lin; Douglas Leaman; John Hiscott
Transcriptional re-programming of primary macrophages reveals distinct apoptotic and anti-tumoral functions of IRF-3 and IRF-7.
European journal of immunology 2009;39(2):527-40.
2009: Long Yang; Tiejun Zhao; Xiaoliu Shi; Peyman Nakhaei; Yunling Wang; Qiang Sun; John Hiscott; Rongtuan Lin
Functional analysis of a dominant negative mutation of interferon regulatory factor 5.
PloS one 2009;4(5):e5500.
2008: Thi Lien-Anh Nguyên; Hesham Abdelbary; Meztli Arguello; Caroline Breitbach; Simon Leveille; Jean-Simon Diallo; Amber Yasmeen; Tarek A Bismar; David H Kirn; Theresa Falls; Valerie E Snoulten; Barbara C Vanderhyden; Joel Werier; Harold Atkins; Markus J V Vähä-Koskela; David F Stojdl; John C Bell; John Hiscott
Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):14981-6.
2008: Vanessa Fonseca Tumilasci; Stephanie Olière; Thi Lien-Ahn Nguyên; April Shamy; John Bell; John Hiscott
Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis.
Journal of virology 2008;82(17):8487-99.
2008: Stephanie Oliere; Meztli Arguello; Thibault Mesplede; Vanessa Tumilasci; Peyman Nakhaei; David Stojdl; Nahum Sonenberg; John Bell; John Hiscott
Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation.
Journal of virology 2008;82(12):5735-49.
2008: David Escors; Luciene Lopes; Rongtuan Lin; John Hiscott; Shizuo Akira; Roger J Davis; Mary K Collins
Targeting dendritic cell signaling to regulate the response to immunization.
Blood 2008;111(6):3050-61.
2007: Meztli D Arguello; John Hiscott
Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates.
Cell host & microbe 2007;2(6):367-9.
2007: Mayra Solis; Delphine Goubau; John Hiscott
RIG-I has guts: identification of a role for RIG-I in colitis development.
Cell research 2007;17(12):974-5.
2007: Agnès Lezin; Nicolas Gillet; Stéphane Olindo; Aïssatou Signaté; Nathalie Grandvaux; Olivier Verlaeten; Gildas Belrose; Marcelo de Carvalho Bittencourt; John Hiscott; Becca Asquith; Arsène Burny; Didier Smadja; Raymond Césaire; Luc Willems
Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1 associated myelopathy/tropical spastic paraparesis patients.
Blood 2007;110(10):3722-8.
2007: John Hiscott
Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response.
Cytokine & growth factor reviews 2007;18(5-6):483-90.
2007: Ehssan Sharif-Askari; Peyman Nakhaei; Stephanie Oliere; Vanessa Tumilasci; Eduardo Hernandez; Peter Wilkinson; Rongtuan Lin; John Bell; John Hiscott
Bax-dependent mitochondrial membrane permeabilization enhances IRF3-mediated innate immune response during VSV infection.
Virology 2007;365(1):20-33.
2007: Guy Lemay; Vanessa Tumilasci; John Hiscott
Uncoating reo: uncovering the steps critical for oncolysis.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(8):1406-7.
2007: Tiejun Zhao; Long Yang; Qiang Sun; Meztli Arguello; Dean W Ballard; John Hiscott; Rongtuan Lin
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.
Nature immunology 2007;8(6):592-600.
2007: John Hiscott
Triggering the innate antiviral response through IRF-3 activation.
The Journal of biological chemistry 2007;282(21):15325-9.
2007: Mayra Solis; Raphaëlle Romieu-Mourez; Delphine Goubau; Nathalie Grandvaux; Thibault Mesplede; Ilkka Julkunen; Alessandra Nardin; Margarita Salcedo; John Hiscott
Involvement of TBK1 and IKKepsilon in lipopolysaccharide-induced activation of the interferon response in primary human macrophages.
European journal of immunology 2007;37(2):528-39.
2006: John Hiscott; Judith Lacoste; Rongtuan Lin
Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease.
Biochemical pharmacology 2006;72(11):1477-84.
2006: Mayra Solis; Delphine Goubau; Raphaëlle Romieu-Mourez; Pierre Genin; Ahmet Civas; John Hiscott
Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.
Biochemical pharmacology 2006;72(11):1469-76.
2006: Raphaëlle Romieu-Mourez; Mayra Solis; Alessandra Nardin; Delphine Goubau; Véronique Baron-Bodo; Rongtuan Lin; Bernard Massie; Margarita Salcedo; John Hiscott
Distinct roles for IFN regulatory factor (IRF)-3 and IRF-7 in the activation of antitumor properties of human macrophages.
Cancer research 2006;66(21):10576-85.
2006: John Hiscott; T-L A Nguyen; Meztli Arguello; Peyman Nakhaei; Suzanne Paz
Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses.
Oncogene 2006;25(51):6844-67.
2006: Annie Bibeau-Poirier; Simon-Pierre Gravel; Jean-François Clément; Sébastien Rolland; Geneviève Rodier; Philippe Coulombe; John Hiscott; Nathalie Grandvaux; Sylvain Meloche; Marc J Servant
Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(8):5059-67.
2006: Jennifer Harris; Stéphanie Olière; Sonia Sharma; Qiang Sun; Rongtuan Lin; John Hiscott; Nathalie Grandvaux
Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2527-35.
2006: Mayra Solis; Peter Wilkinson; Raphaelle Romieu; Eduardo Hernandez; Mark A Wainberg; John Hiscott
Gene expression profiling of the host response to HIV-1 B, C, or A/E infection in monocyte-derived dendritic cells.
Virology 2006;352(1):86-99.
2006: Rongtuan Lin; Judith Lacoste; Peyman Nakhaei; Qiang Sun; Long Yang; Suzanne Paz; Peter Wilkinson; Ilkka Julkunen; Damien Vitour; Eliane F Meurs; John Hiscott
Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage.
Journal of virology 2006;80(12):6072-83.
2006: Meztli Arguello; Suzanne Paz; Eduardo Hernandez; Catherine Corriveau-Bourque; Lama M Fawaz; John Hiscott; Rongtuan Lin
Leukotriene A4 hydrolase expression in PEL cells is regulated at the transcriptional level and leads to increased leukotriene B4 production.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):7051-61.
2006: Ahmet Civas; Pierre Génin; Pierre Morin; Rongtuan Lin; John Hiscott
Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.
The Journal of biological chemistry 2006;281(8):4856-66.
2006: Sylvie Bannwarth; sébastien lainé; Aïcha Daher; Nathalie Grandvaux; Guerline Clerzius; Andrea LeBlanc; John Hiscott; Anne Gatignol
Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes.
Journal of molecular biology 2006;355(5):898-910.
2006: John Hiscott; Rongtuan Lin; Peyman Nakhaei; Suzanne Paz
MasterCARD: a priceless link to innate immunity.
Trends in molecular medicine 2006;12(2):53-6.
2006: Rongtuan Lin; Long Yang; Peyman Nakhaei; Qiang Sun; Ehssan Sharif-Askari; Ilkka Julkunen; John Hiscott
Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.
The Journal of biological chemistry 2006;281(4):2095-103.
2006: Raymond Césaire; S Olière; Ehssan Sharif-Askari; Martin Loignon; Agnès Lézin; Stéphane Olindo; G Panelatti; Mirdad Kazanji; Raquel Aloyz; Lawrence Panasci; J C Bell; John Hiscott
Oncolytic activity of vesicular stomatitis virus in primary adult T-cell leukemia.
Oncogene 2006;25(3):349-58.
2006: Suzanne Paz; Qiang Sun; Peyman Nakhaei; Raphaëlle Romieu-Mourez; Delphine Goubau; Ilkka Julkunen; Rongtuan Lin; John Hiscott
Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.
Cellular and molecular biology (Noisy-le-Grand, France) 2006;52(1):17-28.
2005: Laura Pickell; Pamela Tran; Daniel Leclerc; John Hiscott; Rima Rozen
Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity.
Biochimica et biophysica acta 2005;1731(2):104-14.
2005: Yan Desfosses; Mayra Solis; Qiang Sun; Nathalie Grandvaux; Carine Van Lint; Arsène Burny; Anne Gatignol; Mark A Wainberg; Rongtuan Lin; John Hiscott
Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.
Journal of virology 2005;79(14):9180-91.
2005: Nathalie Grandvaux; François Gaboriau; Jennifer Harris; Benjamin R Tenoever; Rongtuan Lin; John Hiscott
Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response.
The FEBS journal 2005;272(12):3120-31.
2005: Adrien Breiman; Nathalie Grandvaux; Rongtuan Lin; Catherine Ottone; Shizuo Akira; Mitsutoshi Yoneyama; Takashi Fujita; John Hiscott; Eliane F Meurs
Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon.
Journal of virology 2005;79(7):3969-78.
2005: Rongtuan Lin; Long Yang; Meztli Arguello; Claudia Penafuerte; John Hiscott
A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.
The Journal of biological chemistry 2005;280(4):3088-95.
2005: Yaël Mamane; Martin Loignon; Jennifer Palmer; Eduardo Hernandez; Raymond Césaire; Moulay A Alaoui-Jamali; John Hiscott
Repression of DNA repair mechanisms in IRF-4-expressing and HTLV-I-infected T lymphocytes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005;25(1):43-51.
2004: Benjamin R Tenoever; Sonia Sharma; Wen Zou; Qiang Sun; Nathalie Grandvaux; Ilkka Julkunen; Hiroaki Hemmi; M Yamamoto; Shizuo Akira; Wen-Chen Yeh; Rongtuan Lin; John Hiscott
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
Journal of virology 2004;78(19):10636-49.
2004: Marco Sgarbanti; Meztli Arguello; Benjamin R Tenoever; Angela Battistini; Rongtuan Lin; John Hiscott
A requirement for NF-kappaB induction in the production of replication-competent HHV-8 virions.
Oncogene 2004;23(34):5770-80.
2004: Kristen Miller; Susan McArdle; Michael J Gale; David A Geller; Benjamin R Tenoever; John Hiscott; David R Gretch; Stephen Polyak
Effects of the hepatitis C virus core protein on innate cellular defense pathways.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004;24(7):391-402.
2003: John Hiscott; Nathalie Grandvaux; Sonia Sharma; Benjamin R Tenoever; Marc J Servant; Rongtuan Lin
Convergence of the NF-kappaB and interferon signaling pathways in the regulation of antiviral defense and apoptosis.
Annals of the New York Academy of Sciences 2003;1010():237-48.
2003: David F Stojdl; Brian Lichty; Benjamin R Tenoever; Jennifer M Paterson; Anthony T Power; Shane Knowles; Ricardo Marius; Jennifer Reynard; Laurent Poliquin; Harold Atkins; Earl G Brown; Russell K Durbin; Joan E Durbin; John Hiscott; John C Bell
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents.
Cancer cell 2003;4(4):263-75.
2003: Pier-Luigi Battisti; Aïcha Daher; Sylvie Bannwarth; Johannes Voortman; Keith W C Peden; John Hiscott; Andrew J Mouland; Richard Benarous; Anne Gatignol
Additive activity between the trans-activation response RNA-binding protein, TRBP2, and cyclin T1 on HIV type 1 expression and viral production in murine cells.
AIDS research and human retroviruses 2003;19(9):767-78.
2003: Sonia Sharma; Benjamin R Tenoever; Nathalie Grandvaux; Guo-Ping Zhou; Rongtuan Lin; John Hiscott
Triggering the interferon antiviral response through an IKK-related pathway.
Science (New York, N.Y.) 2003;300(5622):1148-51.
2003: Marc J Servant; Nathalie Grandvaux; Benjamin R Tenoever; Delphine Duguay; Rongtuan Lin; John Hiscott
Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA.
The Journal of biological chemistry 2003;278(11):9441-7.
2003: Meztli Arguello; Marco Sgarbanti; Eduardo Hernandez; Yaël Mamane; Sonia Sharma; Marc J Servant; Rongtuan Lin; John Hiscott
Disruption of the B-cell specific transcriptional program in HHV-8 associated primary effusion lymphoma cell lines.
Oncogene 2003;22(7):964-73.
2002: Yaël Mamane; Nathalie Grandvaux; Eduardo Hernandez; Sonia Sharma; Steve A Innocente; Jonathan M Lee; Nazli Azimi; Rongtuan Lin; John Hiscott
Repression of IRF-4 target genes in human T cell leukemia virus-1 infection.
Oncogene 2002;21(44):6751-65.
2002: Delphine Duguay; François Mercier; John Stagg; Daniel Martineau; Jonathan Bramson; Marc J Servant; Rongtuan Lin; Jacques Galipeau; John Hiscott
In vivo interferon regulatory factor 3 tumor suppressor activity in B16 melanoma tumors.
Cancer research 2002;62(18):5148-52.
2002: Sonia Sharma; Nathalie Grandvaux; Yaël Mamane; Pierre Genin; Nazli Azimi; Thomas Waldmann; John Hiscott
Regulation of IFN regulatory factor 4 expression in human T cell leukemia virus-I-transformed T cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3120-30.
2002: Marc J Servant; Nathalie Grandvaux; John Hiscott
Multiple signaling pathways leading to the activation of interferon regulatory factor 3.
Biochemical pharmacology 2002;64(5-6):985-92.
2002: Tudor M Baetu; John Hiscott
On the TRAIL to apoptosis.
Cytokine & growth factor reviews 2002;13(3):199-207.
2002: Jennifer M Mariner; Yaël Mamane; John Hiscott; Thomas Waldmann; Nazli Azimi
IFN regulatory factor 4 participates in the human T cell lymphotropic virus type I-mediated activation of the IL-15 receptor alpha promoter.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5667-74.
2002: Nathalie Grandvaux; Benjamin R Tenoever; Marc J Servant; John Hiscott
The interferon antiviral response: from viral invasion to evasion.
Current opinion in infectious diseases 2002;15(3):259-67.
2002: Nathalie Grandvaux; Marc J Servant; Benjamin R Tenoever; Ganes C Sen; Siddharth Balachandran; Glen N Barber; Rongtuan Lin; John Hiscott
Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes.
Journal of virology 2002;76(11):5532-9.
2002: Philippe Roof; Maria Ricci; Pierre Genin; Monty A Montano; Max Essex; Mark A Wainberg; Anne Gatignol; John Hiscott
Differential regulation of HIV-1 clade-specific B, C, and E long terminal repeats by NF-kappaB and the Tat transactivator.
Virology 2002;296(1):77-83.
2002: Benjamin R Tenoever; Marc J Servant; Nathalie Grandvaux; Rongtuan Lin; John Hiscott
Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation.
Journal of virology 2002;76(8):3659-69.
2002: Pierre Morin; Jose Bragança; Marie-Thérèse Bandu; Rongtuan Lin; John Hiscott; Janine Doly; Ahmet Civas
Preferential binding sites for interferon regulatory factors 3 and 7 involved in interferon-A gene transcription.
Journal of molecular biology 2002;316(5):1009-22.
2002: Yaël Mamane; Sonia Sharma; Nathalie Grandvaux; Eduardo Hernandez; John Hiscott
IRF-4 activities in HTLV-I-induced T cell leukemogenesis.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(1):135-43.
2002: Angela Battistini; Giulia Marsili; Marco Sgarbanti; Barbara Ensoli; John Hiscott
IRF regulation of HIV-1 long terminal repeat activity.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(1):27-37.
2001: Sylvie Bannwarth; L Talakoub; F Letourneur; M Duarte; Damian F J Purcell; John Hiscott; Anne Gatignol
Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line.
The Journal of biological chemistry 2001;276(52):48803-13.
2001: Eliana M Coccia; Emilia Stellacci; Mauro Valtieri; Barbara Masella; Tiziana Feccia; Giovanna Marziali; John Hiscott; Ugo Testa; Cesare Peschle; Angela Battistini
Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation.
The Biochemical journal 2001;360(Pt 2):285-94.
2001: T M Baetu; H Kwon; Sonia Sharma; Nathalie Grandvaux; John Hiscott
Disruption of NF-kappaB signaling reveals a novel role for NF-kappaB in the regulation of TNF-related apoptosis-inducing ligand expression.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3164-73.
2001: Cecile Le Page; O Popescu; P Génin; J Lian; André Paquin; Jacques Galipeau; John Hiscott
Disruption of NF-kappa B signaling and chemokine gene activation by retroviral mediated expression of IKK gamma/NEMO mutants.
Virology 2001;286(2):422-33.
2001: T Ishii; H Kwon; John Hiscott; G Mosialos; Antonis E Koromilas
Activation of the I kappa B alpha kinase (IKK) complex by double-stranded RNA-binding defective and catalytic inactive mutants of the interferon-inducible protein kinase PKR.
Oncogene 2001;20(15):1900-12.
2001: Rongtuan Lin; Pierre Genin; Yaël Mamane; Marco Sgarbanti; Angela Battistini; William J Harrington; Glen N Barber; John Hiscott
HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators.
Oncogene 2001;20(7):800-11.
2001: Marc J Servant; B ten Oever; Cecile Le Page; L Conti; S Gessani; Ilkka Julkunen; Rongtuan Lin; John Hiscott
Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3.
The Journal of biological chemistry 2001;276(1):355-63.
2001: John Hiscott; H Kwon; P Génin
Hostile takeovers: viral appropriation of the NF-kappaB pathway.
The Journal of clinical investigation 2001;107(2):143-51.
2000: Rongtuan Lin; Yaël Mamane; John Hiscott
Multiple regulatory domains control IRF-7 activity in response to virus infection.
The Journal of biological chemistry 2000;275(44):34320-7.
2000: Sonia Sharma; Yaël Mamane; Nathalie Grandvaux; J Bartlett; L Petropoulos; Rongtuan Lin; John Hiscott
Activation and regulation of interferon regulatory factor 4 in HTLV type 1-infected T lymphocytes.
AIDS research and human retroviruses 2000;16(16):1613-22.
2000: Rongtuan Lin; P Génin; Yaël Mamane; John Hiscott
Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7.
Molecular and cellular biology 2000;20(17):6342-53.
2000: P Génin; M Algarté; P Roof; Rongtuan Lin; John Hiscott
Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5352-61.
2000: C Heylbroeck; Siddharth Balachandran; Marc J Servant; C DeLuca; Glen N Barber; Rongtuan Lin; John Hiscott
The IRF-3 transcription factor mediates Sendai virus-induced apoptosis.
Journal of virology 2000;74(8):3781-92.
2000: Yaël Mamane; Sonia Sharma; L Petropoulos; Rongtuan Lin; John Hiscott
Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52.
Immunity 2000;12(2):129-40.
2000: Cecile Le Page; P Génin; M G Baines; John Hiscott
Interferon activation and innate immunity.
Reviews in immunogenetics 2000;2(3):374-86.
1999: H Nguyen; L Teskey; Rongtuan Lin; John Hiscott
Identification of the secretory leukocyte protease inhibitor (SLPI) as a target of IRF-1 regulation.
Oncogene 1999;18(39):5455-63.
1999: Yaël Mamane; C Heylbroeck; P Génin; M Algarté; Marc J Servant; Cecile Le Page; C DeLuca; H Kwon; Rongtuan Lin; John Hiscott
Interferon regulatory factors: the next generation.
Gene 1999;237(1):1-14.
1999: C DeLuca; H Kwon; Rongtuan Lin; Mark A Wainberg; John Hiscott
NF-kappaB activation and HIV-1 induced apoptosis.
Cytokine & growth factor reviews 1999;10(3-4):235-53.
1999: P Génin; Yaël Mamane; H Kwon; Cecile Le Page; Mark A Wainberg; John Hiscott
Differential regulation of CC chemokine gene expression in human immunodeficiency virus-infected myeloid cells.
Virology 1999;261(2):205-15.
1999: M Algarté; H Kwon; P Génin; John Hiscott
Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter.
Molecular and cellular biology 1999;19(9):6140-53.
1999: C DeLuca; L Petropoulos; D Zmeureanu; John Hiscott
Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells.
The Journal of biological chemistry 1999;274(19):13010-6.
1999: Rongtuan Lin; Yaël Mamane; John Hiscott
Structural and functional analysis of interferon regulatory factor 3: localization of the transactivation and autoinhibitory domains.
Molecular and cellular biology 1999;19(4):2465-74.
1999: M Algarté; H Nguyen; C Heylbroeck; Rongtuan Lin; John Hiscott
IkappaB-mediated inhibition of virus-induced beta interferon transcription.
Journal of virology 1999;73(4):2694-702.
1999: Eliana M Coccia; N Del Russo; Emilia Stellacci; Roberto Orsatti; Eleonora Benedetti; Giovanna Marziali; John Hiscott; Angela Battistini
Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2.
Oncogene 1999;18(12):2129-37.
1999: Rongtuan Lin; C Heylbroeck; Pierre Genin; PAULA PITHA-ROWE; John Hiscott
Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.
Molecular and cellular biology 1999;19(2):959-66.
1999: W Spencer; H Kwon; P Crépieux; N Leclerc; Rongtuan Lin; John Hiscott
Taxol selectively blocks microtubule dependent NF-kappaB activation by phorbol ester via inhibition of IkappaBalpha phosphorylation and degradation.
Oncogene 1999;18(2):495-505.
1999: Rongtuan Lin; John Hiscott
A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity.
Molecular and cellular biochemistry 1999;191(1-2):169-80.
1999: John Hiscott; PAULA PITHA-ROWE; Pierre Genin; H Nguyen; C Heylbroeck; Yaël Mamane; M Algarte; Rongtuan Lin
Triggering the interferon response: the role of IRF-3 transcription factor.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1999;19(1):1-13.
1998: L Petropoulos; John Hiscott
Association between HTLV-1 Tax and I kappa B alpha is dependent on the I kappa B alpha phosphorylation state.
Virology 1998;252(1):189-99.
1998: Rongtuan Lin; C Heylbroeck; PAULA PITHA-ROWE; John Hiscott
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.
Molecular and cellular biology 1998;18(5):2986-96.
1998: C DeLuca; H Kwon; Nadine Pelletier; Mark A Wainberg; John Hiscott
NF-kappaB protects HIV-1-infected myeloid cells from apoptosis.
Virology 1998;244(1):27-38.
1998: M Dehbi; John Hiscott; Jerry Pelletier
Activation of the wt1 Wilms' tumor suppressor gene by NF-kappaB.
Oncogene 1998;16(16):2033-9.
1998: H Kwon; Nadine Pelletier; C DeLuca; Pierre Genin; S Cisternas; Rongtuan Lin; Mark A Wainberg; John Hiscott
Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells.
The Journal of biological chemistry 1998;273(13):7431-40.
1997: H Nguyen; John Hiscott; PAULA PITHA-ROWE
The growing family of interferon regulatory factors.
Cytokine & growth factor reviews 1997;8(4):293-312.
1997: P Crépieux; H Kwon; N Leclerc; W Spencer; Stéphane Richard; Rongtuan Lin; John Hiscott
I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain.
Molecular and cellular biology 1997;17(12):7375-85.
1997: Chen Liang; Xiaodong Li; Yudong Quan; Michael Laughrea; Lawrence Kleiman; John Hiscott; Mark A Wainberg
Sequence elements downstream of the human immunodeficiency virus type 1 long terminal repeat are required for efficient viral gene transcription.
Journal of molecular biology 1997;272(2):167-77.
1997: H Nguyen; Rongtuan Lin; John Hiscott
Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins.
Oncogene 1997;15(12):1425-35.
1997: R Lee; P Beauparlant; H Elford; P Ponka; John Hiscott
Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds.
Virology 1997;234(2):277-90.
1997: John Hiscott; P Beauparlant; P Crepieux; C DeLuca; H Kwon; Rongtuan Lin; L Petropoulos
Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.
Journal of leukocyte biology 1997;62(1):82-92.
1997: L Conti; John Hiscott; Maddalena Papacchini; A Roulston; M A Wainberg; F Belardelli; Sandra Gessani
Induction of relA(p65) and I kappa B alpha subunit expression during differentiation of human peripheral blood monocytes to macrophages.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(4):435-42.
1997: K Nagai; Andrew Hoi-Tao Wong; Suiyang Li; W N Tam; Andrew R Cuddihy; Nahum Sonenberg; M B Mathews; John Hiscott; Mark A Wainberg; Antonis E Koromilas
Induction of CD4 expression and human immunodeficiency virus type 1 replication by mutants of the interferon-inducible protein kinase PKR.
Journal of virology 1997;71(2):1718-25.
1996: L Petropoulos; Rongtuan Lin; John Hiscott
Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein.
Virology 1996;225(1):52-64.
1996: P Beauparlant; H Kwon; M Clarke; Rongtuan Lin; Nahum Sonenberg; Mark A Wainberg; John Hiscott
Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication.
Journal of virology 1996;70(9):5777-85.
1996: P Beauparlant; John Hiscott
Biological and biochemical inhibitors of the NF-kappa B/Rel proteins and cytokine synthesis.
Cytokine & growth factor reviews 1996;7(2):175-90.
1996: C DeLuca; A Roulston; Antonis E Koromilas; Mark A Wainberg; John Hiscott
Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation.
Journal of virology 1996;70(8):5183-93.
1996: P Beauparlant; Rongtuan Lin; John Hiscott
The role of the C-terminal domain of I kappa B alpha in protein degradation and stabilization.
The Journal of biological chemistry 1996;271(18):10690-6.
1996: Rongtuan Lin; P Beauparlant; C Makris; Sylvain Meloche; John Hiscott
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability.
Molecular and cellular biology 1996;16(4):1401-9.
1995: John Hiscott; L Petropoulos; J Lacoste
Molecular interactions between HTLV-1 Tax protein and the NF-kappa B/kappa B transcription complex.
Virology 1995;214(1):3-11.
1995: Antonis E Koromilas; C Cantin; A W Craig; R Jagus; John Hiscott; Nahum Sonenberg
The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.
The Journal of biological chemistry 1995;270(43):25426-34.
1995: A Roulston; Rongtuan Lin; P Beauparlant; Mark A Wainberg; John Hiscott
Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factors.
Microbiological reviews 1995;59(3):481-505.
1995: H Nguyen; A Mustafa; John Hiscott; Rongtuan Lin
Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain.
Oncogene 1995;11(3):537-44.
1995: R Bitar; P Beauparlant; Rongtuan Lin; PAULA PITHA-ROWE; John Hiscott
Retrovirus-mediated transfer of nuclear factor-kappa B subunit genes modulates I kappa B alpha and interferon beta expression.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(8):965-76.
1995: Rongtuan Lin; D Gewert; John Hiscott
Differential transcriptional activation in vitro by NF-kappa B/Rel proteins.
The Journal of biological chemistry 1995;270(7):3123-31.
1995: J Lacoste; L Petropoulos; N Pépin; John Hiscott
Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells.
Journal of virology 1995;69(1):564-9.
1994: N Pepin; A Roulston; J Lacoste; Rongtuan Lin; John Hiscott
Subcellular redistribution of HTLV-1 Tax protein by NF-kappa B/Rel transcription factors.
Virology 1994;204(2):706-16.
1994: P Beauparlant; I Kwan; R Bitar; P Chou; Antonis E Koromilas; Nahum Sonenberg; John Hiscott
Disruption of I kappa B alpha regulation by antisense RNA expression leads to malignant transformation.
Oncogene 1994;9(11):3189-97.
1994: E Garoufalis; I Kwan; Rongtuan Lin; A Mustafa; N Pepin; A Roulston; J Lacoste; John Hiscott
Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors.
Journal of virology 1994;68(8):4707-15.
1994: R Lin; A Mustafa; H Nguyen; D Gewert; John Hiscott
Mutational analysis of interferon (IFN) regulatory factors 1 and 2. Effects on the induction of IFN-beta gene expression.
The Journal of biological chemistry 1994;269(26):17542-9.
1994: J Lacoste; J Lanoix; N Pepin; John Hiscott
Interactions between HTLV-I Tax and NF-kappa B/Rel proteins in T cells.
Leukemia 1994;8 Suppl 1():S71-6.
1994: A Roulston; L Conti; V McKiel; Mark A Wainberg; John Hiscott
Virus induction of NF-kappa B/Rel proteins and type I interferon gene expression in myelomonoblastic cells.
Leukemia 1994;8 Suppl 1():S170-4.
1994: J Lanoix; J Lacoste; N Pepin; N Rice; John Hiscott
Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway.
Oncogene 1994;9(3):841-52.
1993: John Hiscott; J Marois; J Garoufalis; M D'Addario; A Roulston; I Kwan; N Pepin; J Lacoste; H Nguyen; G Bensi
Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.
Molecular and cellular biology 1993;13(10):6231-40.
1993: A Roulston; P Beauparlant; N Rice; John Hiscott
Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells.
Journal of virology 1993;67(9):5235-46.
1993: H Soudeyns; R Geleziunas; G Shyamala; John Hiscott; Mark A Wainberg
Identification of a novel glucocorticoid response element within the genome of the human immunodeficiency virus type 1.
Virology 1993;194(2):758-68.
1992: L Cohen; John Hiscott
Characterization of TH3, an induction-specific protein interacting with the interferon beta promoter.
Virology 1992;191(2):589-99.
1992: L Cohen; John Hiscott
Heterodimerization and transcriptional activation in vitro by NF-kappa B proteins.
Journal of cellular physiology 1992;152(1):10-8.
1992: Jean Gosselin; Louis Flamand; M D'Addario; John Hiscott; I Stefanescu; D V Ablashi; Robert C Gallo; José Menezes
Modulatory effects of Epstein-Barr, herpes simplex, and human herpes-6 viral infections and coinfections on cytokine synthesis. A comparative study.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):181-7.
1992: Jean Gosselin; Louis Flamand; M D'Addario; John Hiscott; José Menezes
Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha.
The Journal of clinical investigation 1992;89(6):1849-56.
1992: A Roulston; M D'Addario; F Boulerice; S Caplan; Mark A Wainberg; John Hiscott
Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells.
The Journal of experimental medicine 1992;175(3):751-63.
1992: M D'Addario; Mark A Wainberg; John Hiscott
Activation of cytokine genes in HIV-1 infected myelomonoblastic cells by phorbol ester and tumor necrosis factor.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):1222-9.
1992: F Boulerice; R Geleziunas; Stephan Bour; H L Li; M D'Addario; A Roulston; John Hiscott; Mark A Wainberg
Differential susceptibilities of U-937 cell clones to infection by human immunodeficiency virus type 1.
Journal of virology 1992;66(2):1183-7.
1992: J F Leblanc; John Hiscott
Differential response of human interferon-beta promoter elements to trans-activation by HSV VP16 and IRF-1.
Virology 1992;186(2):760-3.
1991: J Lacoste; L Cohen; John Hiscott
NF-kappa B activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I.
Virology 1991;184(2):553-62.
1991: Louis Flamand; Jean Gosselin; M D'Addario; John Hiscott; D V Ablashi; Robert C Gallo; José Menezes
Human herpesvirus 6 induces interleukin-1 beta and tumor necrosis factor alpha, but not interleukin-6, in peripheral blood mononuclear cell cultures.
Journal of virology 1991;65(9):5105-10.
1991: L Cohen; J Lacoste; M Parniak; L Daigneault; D Skup; John Hiscott
Stimulation of interferon beta gene transcription in vitro by purified NF-kappa B and a novel TH protein.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991;2(7):323-33.
1991: R Geleziunas; A McQuillan; Areti Malapetsa; M Hutchinson; D Kopriva; Mark A Wainberg; John Hiscott; J Bramson; Lawrence Panasci
Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards.
Journal of the National Cancer Institute 1991;83(8):557-64.
1991: R Geleziunas; Stephan Bour; F Boulerice; John Hiscott; Mark A Wainberg
Diminution of CD4 surface protein but not CD4 messenger RNA levels in monocytic cells infected by HIV-1.
AIDS (London, England) 1991;5(1):29-33.
1991: Jean Gosselin; José Menezes; M D'Addario; John Hiscott; Louis Flamand; G Lamoureux; D Oth
Inhibition of tumor necrosis factor-alpha transcription by Epstein-Barr virus.
European journal of immunology 1991;21(1):203-8.
1990: M D'Addario; A Roulston; Mark A Wainberg; John Hiscott
Coordinate enhancement of cytokine gene expression in human immunodeficiency virus type 1-infected promonocytic cells.
Journal of virology 1990;64(12):6080-9.
1990: M Dubreuil; L Sportza; M D'Addario; J Lacoste; R Rooke; Mark A Wainberg; John Hiscott
Inhibition of HIV-1 transmission by interferon and 3'-azido-3'-deoxythymidine during de novo infection of promonocytic cells.
Virology 1990;179(1):388-94.
1990: M Tremblay; K Numazaki; X G Li; M Gornitsky; John Hiscott; Mark A Wainberg
Resistance to infection by HIV-1 of peripheral blood mononuclear cells from HIV-1-infected patients is probably mediated by neutralizing antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(9):2896-901.
1990: J Lacoste; M D'Addario; A Roulston; Mark A Wainberg; John Hiscott
Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor.
Journal of virology 1990;64(10):4726-34.
1990: J F Leblanc; L Cohen; M Rodrigues; John Hiscott
Synergism between distinct enhanson domains in viral induction of the human beta interferon gene.
Molecular and cellular biology 1990;10(8):3987-93.
1990: S Xanthoudakis; John Hiscott
UV cross-linking of distinct proteins to the PRDII domain of the interferon-beta promoter.
Biochemical and biophysical research communications 1990;167(3):1086-93.
1989: John Hiscott; D Alper; L Cohen; J F Leblanc; L Sportza; A Wong; S Xanthoudakis
Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer.
Journal of virology 1989;63(6):2557-66.
1989: S Xanthoudakis; L Cohen; John Hiscott
Multiple protein-DNA interactions within the human interferon-beta regulatory element.
The Journal of biological chemistry 1989;264(2):1139-45.
1988: S Xanthoudakis; John Hiscott
Modulation of interferon gene transcription by positive and negative cellular factors.
Biochemical and biophysical research communications 1988;154(3):1338-44.
1988: John Hiscott; A Wong; D Alper; S Xanthoudakis
trans activation of type 1 interferon promoters by simian virus 40 T antigen.
Molecular and cellular biology 1988;8(8):3397-405.
1988: A H Marshall; D Alper; John Hiscott
Modulation of nuclear proto-oncogene expression and cellular growth in myeloid leukemic cells by human interferon alpha.
Journal of cellular physiology 1988;135(2):324-31.
1987: S Xanthoudakis; D Alper; John Hiscott
Transient expression of the beta interferon promoter in human cells.
Molecular and cellular biology 1987;7(10):3830-5.
1987: S Xanthoudakis; John Hiscott
Identification of a nuclear DNA binding protein associated with the interferon-beta upstream regulatory region.
The Journal of biological chemistry 1987;262(17):8298-302.