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Coral Ho

Research Profile

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Oligonucleotide Array Sequence Analysis

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Chunmei Wang; Diego F Calvisi; Antonio Cigliano; Salvatore Delogu; Frank Dombrowski; Matthias Evert; Bing Gui; Coral Ho; Lijie Jiang; Sara Ladu; Susie A Lee; Xin Chen
Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.
Coral Ho; Lijie Jiang; Sara Ladu; Susie A Lee; Sandra Mattu; Chunmei Wang; Xin Chen; Salvatore Delogu; Giulia Destefanis; Frank Dombrowski; Matthias Evert; Lingling Fan; Julia Armbruster; Diego F Calvisi
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
Lingling Fan; Bing Gui; Coral Ho; Shiang Huang; Lijie Jiang; Junyan Tao; Chunmei Wang; Chuanrui Xu; Diego F Calvisi; Matthias Evert; Xin Chen
Bmi1 is required for hepatic progenitor cell expansion and liver tumor development.

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All Publications

2012: Chunmei Wang; Diego F Calvisi; Antonio Cigliano; Salvatore Delogu; Frank Dombrowski; Matthias Evert; Bing Gui; Coral Ho; Lijie Jiang; Sara Ladu; Susie A Lee; Xin Chen
Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways.
Journal of hepatology 2012;57(3):577-83.
2012: Coral Ho; Lijie Jiang; Sara Ladu; Susie A Lee; Sandra Mattu; Chunmei Wang; Xin Chen; Salvatore Delogu; Giulia Destefanis; Frank Dombrowski; Matthias Evert; Lingling Fan; Julia Armbruster; Diego F Calvisi
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
Hepatology (Baltimore, Md.) 2012;55(3):833-45.
2012: Lingling Fan; Bing Gui; Coral Ho; Shiang Huang; Lijie Jiang; Junyan Tao; Chunmei Wang; Chuanrui Xu; Diego F Calvisi; Matthias Evert; Xin Chen
Bmi1 is required for hepatic progenitor cell expansion and liver tumor development.
PloS one 2012;7(9):e46472.
2010: Cynthia Kosinski; Daniel E Stange; Chuanrui Xu; Annie Sy Chan; Coral Ho; Siu Tsan Yuen; Randy C Mifflin; Don W Powell; Hans Clevers; Suet Yi Leung; Xin Chen
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development.
Gastroenterology 2010;139(3):893-903.
2009: Chuan-Rui Xu; Susie Lee; Coral Ho; Prashant Bommi; Shi-Ang Huang; Siu Tim Cheung; Goberdhan P Dimri; Xin Chen
Bmi1 functions as an oncogene independent of Ink4A/Arf repression in hepatic carcinogenesis.
Molecular cancer research : MCR 2009;7(12):1937-45.
2009: Sanjay Kakar; Xin Chen; Coral Ho; Lawrence J Burgart; Oyedele Adeyi; Dhanpat Jain; Viabhav Sahai; Linda D Ferrell
Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms.
Histopathology 2009;55(2):197-205.
2009: Mohini A Patil; Susie A Lee; Everardo Macias; Ernest T Lam; Chuanrui Xu; Kirk D Jones; Coral Ho; Marcelo Rodriguez-Puebla; Xin Chen
Role of cyclin D1 as a mediator of c-Met- and beta-catenin-induced hepatocarcinogenesis.
Cancer research 2009;69(1):253-61.
2009: Sanjay Kakar; Xin Chen; Coral Ho; Lawrence J Burgart; Vaibhav Sahai; Somkid Dachrut; Annoel Yabes; Dhanpat Jain; Linda D Ferrell
Chromosomal changes in fibrolamellar hepatocellular carcinoma detected by array comparative genomic hybridization.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(1):134-41.
2008: Susie A Lee; Coral Ho; Ritu Roy; Cynthia Kosinski; Mohini A Patil; Aaron D Tward; Jane Fridlyand; Xin Chen
Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer.
Hepatology (Baltimore, Md.) 2008;47(4):1200-10.
2007: Cynthia Kosinski; Vivian S W Li; Annie S Y Chan; Ji Zhang; Coral Ho; Wai Yin Tsui; Tsun Leung Chan; Randy C Mifflin; Don W Powell; Siu Tsan Yuen; Suet Yi Leung; Xin Chen
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(39):15418-23.
2006: Suet Yi Leung; Coral Ho; I-Ping Tu; Rui Li; Samuel So; Kent-Man Chu; Siu Tsan Yuen; Xin Chen
Comprehensive analysis of 19q12 amplicon in human gastric cancers.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006;19(6):854-63.
2006: Dong Li Guo; Ji Zhang; Siu Tsan Yuen; Wai Yin Tsui; Annie S Y Chan; Coral Ho; Jiafu Ji; Suet Yi Leung; Xin Chen
Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours.
Carcinogenesis 2006;27(3):454-64.
2006: Mohini A Patil; Ji Zhang; Coral Ho; Siu Tim Cheung; Sheung-Tat Fan; Xin Chen
Hedgehog signaling in human hepatocellular carcinoma.
Cancer biology & therapy 2006;5(1):111-7.
2005: Mohini A Patil; Ines Gütgemann; Ji Zhang; Coral Ho; Siu Tim Cheung; David Ginzinger; Rui Li; Karl J Dykema; Samuel So; Sheung-Tat Fan; Sanjay Kakar; Kyle A Furge; Reinhard Büttner; Xin Chen
Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma.
Carcinogenesis 2005;26(12):2050-7.
2005: Mohini A Patil; Mei-Sze Chua; Kuang-Hung Pan; Richard Lin; Chih-Jian Lih; Siu Tim Cheung; Coral Ho; Rui Li; Sheung-Tat Fan; Stanley N Cohen; Xin Chen; Samuel So
An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma.
Oncogene 2005;24(23):3737-47.
2005: Kyle A Furge; Karl J Dykema; Coral Ho; Xin Chen
Comparison of array-based comparative genomic hybridization with gene expression-based regional expression biases to identify genetic abnormalities in hepatocellular carcinoma.
BMC genomics 2005;6():67.