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Paula Hochman

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Michael L Dustin; Toby Starr; Daniel Coombs; Gerard R Majeau; Werner Meier; Paula S Hochman; Adam Douglass; Ronald D Vale; Byron Goldstein; Adrian Whitty
Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion.
Aldo Amatucci; Tatiana I Novobrantseva; Kevin Gilbride; Margot Brickelmaier; Paula S Hochman; Alexander Ibraghimov
Recombinant ST2 boosts hepatic Th2 response in vivo.
Tatiana I Novobrantseva; Gerard R Majeau; Aldo Amatucci; Sophia Kogan; Ian Brenner; Stefano Casola; Mark J Shlomchik; Victor E Koteliansky; Paula S Hochman; Alexander Ibraghimov
Attenuated liver fibrosis in the absence of B cells.

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All Publications

2007: Michael L Dustin; Toby Starr; Daniel Coombs; Gerard R Majeau; Werner Meier; Paula S Hochman; Adam Douglass; Ronald D Vale; Byron Goldstein; Adrian Whitty
Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion.
The Journal of biological chemistry 2007;282(48):34748-57.
2007: Aldo Amatucci; Tatiana I Novobrantseva; Kevin Gilbride; Margot Brickelmaier; Paula S Hochman; Alexander Ibraghimov
Recombinant ST2 boosts hepatic Th2 response in vivo.
Journal of leukocyte biology 2007;82(1):124-32.
2005: Tatiana I Novobrantseva; Gerard R Majeau; Aldo Amatucci; Sophia Kogan; Ian Brenner; Stefano Casola; Mark J Shlomchik; Victor E Koteliansky; Paula S Hochman; Alexander Ibraghimov
Attenuated liver fibrosis in the absence of B cells.
The Journal of clinical investigation 2005;115(11):3072-82.
2004: Jochen Mattner; Alexandra Wandersee-Steinhäuser; Andreas Pahl; Martin Röllinghoff; Gerard R Majeau; Paula S Hochman; Christian Bogdan
Protection against progressive leishmaniasis by IFN-beta.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7574-82.
2004: Robert M Arduini; Zhifang Li; Alan Rapoza; Robert Gronke; Donna M Hess; Dingyi Wen; Konrad Miatkowski; Caroline Coots; Azita Kaffashan; Nelly Viseux; Jeannine Delaney; Bruno Domon; Carmen N Young; Raymond Boynton; Ling Ling Chen; Liqing Chen; Matthew Betzenhauser; Stephan Miller; Alan Gill; R Blake Pepinsky; Paula S Hochman; Darren P Baker
Expression, purification, and characterization of rat interferon-beta, and preparation of an N-terminally PEGylated form with improved pharmacokinetic parameters.
Protein expression and purification 2004;34(2):229-42.
2003: Kalpit A Vora; Li Chun Wang; Sambasiva P Rao; Zhong-Ying Liu; Gerard R Majeau; Anne H Cutler; Paula S Hochman; Martin L Scott; Susan L Kalled
Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):547-51.
2002: Antonio J da Silva; Margot Brickelmaier; Gerard R Majeau; Zhifang Li; Lihe Su; Yen-Ming Hsu; Paula S Hochman
Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4462-71.
2002: Antonio J da Silva; Margot Brickelmaier; Gerard R Majeau; Alexander V Lukashin; John Peyman; Adrian Whitty; Paula S Hochman
Comparison of gene expression patterns induced by treatment of human umbilical vein endothelial cells with IFN-alpha 2b vs. IFN-beta 1a: understanding the functional relationship between distinct type I interferons that act through a common receptor.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(2):173-88.
2001: LA Runkel; C De Dios; Michael Karpusas; D Baker; Zhifang Li; Mohammad Zafari; Matthew Betzenhauser; C Muldowney; Stephan Miller; Philip N. Redlich; S E Grossberg; Adrian Whitty; Paula S Hochman
Mapping of IFN-beta epitopes important for receptor binding and biologic activation: comparison of results achieved using antibody-based methods and alanine substitution mutagenesis.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2001;21(11):931-41.
2001: Paul D Rennert; Paula S Hochman; R A Flavell; D D Chaplin; S Jayaraman; Jeffrey L Browning; Y X Fu
Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice.
The Journal of experimental medicine 2001;193(11):1227-38.
2001: R Blake Pepinsky; Doreen J Lepage; Alan Gill; Abhijit Chakraborty; S Vaidyanathan; M Green; Darren P Baker; Eric T Whalley; Paula S Hochman; P Martin
Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity.
The Journal of pharmacology and experimental therapeutics 2001;297(3):1059-66.
2000: LA Runkel; C deDios; Michael Karpusas; Matthew Betzenhauser; C Muldowney; Mohammad Zafari; Christopher D Benjamin; Stephan Miller; Paula S Hochman; Adrian Whitty
Systematic mutational mapping of sites on human interferon-beta-1a that are important for receptor binding and functional activity.
Biochemistry 2000;39(10):2538-51.
1999: Robert M Arduini; Kathy Strauch; LA Runkel; M M Carlson; Xiaoping Hronowski; Susan F Foley; Carmen N Young; W Cheng; Paula S Hochman; Darren P Baker
Characterization of a soluble ternary complex formed between human interferon-beta-1a and its receptor chains.
Protein science : a publication of the Protein Society 1999;8(9):1867-77.
1999: Margot Brickelmaier; Paula S Hochman; R Baciu; B Chao; J H Cuervo; Adrian Whitty
ELISA methods for the analysis of antibody responses induced in multiple sclerosis patients treated with recombinant interferon-beta.
Journal of immunological methods 1999;227(1-2):121-35.
1999: Gerard R Majeau; Adrian Whitty; K Yim; Werner Meier; Paula S Hochman
Low affinity binding of an LFA-3/IgG1 fusion protein to CD2+ T cells is independent of cell activation.
Cell adhesion and communication 1999;7(3):267-79.
1998: Michael Karpusas; Adrian Whitty; LA Runkel; Paula S Hochman
The structure of human interferon-beta: implications for activity.
Cellular and molecular life sciences : CMLS 1998;54(11):1203-16.
1998: Paul D Rennert; D James; Fabienne Mackay; Jeffrey L Browning; Paula S Hochman
Lymph node genesis is induced by signaling through the lymphotoxin beta receptor.
Immunity 1998;9(1):71-9.
1997: Paul D Rennert; Jeffrey L Browning; Paula S Hochman
Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization.
International immunology 1997;9(11):1627-39.
1997: Jeffrey L Browning; Irene Sizing; P Lawton; PR Bourdon; Paul D Rennert; Gerard R Majeau; Christine Ambrose; Cathy Hession; Konrad Miatkowski; D A Griffiths; Apinya Ngam-Ek; Werner Meier; Christopher D Benjamin; Paula S Hochman
Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3288-98.
1997: Fabienne Mackay; Gerard R Majeau; P Lawton; Paula S Hochman; Jeffrey L Browning
Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice.
European journal of immunology 1997;27(8):2033-42.
1996: Paul D Rennert; Jeffrey L Browning; Reina E Mebius; Fabienne Mackay; Paula S Hochman
Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs.
The Journal of experimental medicine 1996;184(5):1999-2006.
1996: Fabienne Mackay; Gerard R Majeau; Paula S Hochman; Jeffrey L Browning
Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell types.
The Journal of biological chemistry 1996;271(40):24934-8.
1996: R J Kaplon; Paula S Hochman; Robert Michler; Pawel Kwiatkowski; Niloo M Edwards; C L Berger; H Xu; Werner Meier; B P Wallner; P Chisholm; Charles C Marboe
Short course single agent therapy with an LFA-3-IgG1 fusion protein prolongs primate cardiac allograft survival.
Transplantation 1996;61(3):356-63.
1995: Werner Meier; A Gill; M Rogge; R Dabora; Gerard R Majeau; F B Oleson; W E Jones; D Frazier; Konrad Miatkowski; Paula S Hochman
Immunomodulation by LFA3TIP, an LFA-3/IgG1 fusion protein: cell line dependent glycosylation effects on pharmacokinetics and pharmacodynamic markers.
Therapeutic immunology 1995;2(3):159-71.
1995: Paula S Hochman; Gerard R Majeau; Fabienne Mackay; Jeffrey L Browning
Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands.
Journal of inflammation 1995;46(4):220-34.
1995: L Osborn; E S Day; G T Miller; Michael Karpusas; R Tizard; S C Meuer; Paula S Hochman
Amino acid residues required for binding of lymphocyte function-associated antigen 3 (CD58) to its counter-receptor CD2.
The Journal of experimental medicine 1995;181(1):429-34.
1994: P L Chisholm; C A Williams; W E Jones; Gerard R Majeau; F B Oleson; B Burrus-Fischer; Werner Meier; Paula S Hochman
The effects of an immunomodulatory LFA3-IgG1 fusion protein on nonhuman primates.
Therapeutic immunology 1994;1(4):205-16.
1994: Gerard R Majeau; Werner Meier; B Jimmo; D Kioussis; Paula S Hochman
Mechanism of lymphocyte function-associated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2753-67.
1993: G T Miller; Paula S Hochman; Werner Meier; R Tizard; Sarah A Bixler; M D Rosa; B P Wallner
Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses.
The Journal of experimental medicine 1993;178(1):211-22.
1987: D H Sherman; Paula S Hochman; R Dick; R Tizard; K L Ramachandran; R A Flavell; B T Huber
Molecular analysis of antigen recognition by insulin-specific T-cell hybridomas from B6 wild-type and bm12 mutant mice.
Molecular and cellular biology 1987;7(5):1865-72.
1984: Paula S Hochman; B T Huber
A class II gene conversion event defines an antigen-specific Ir gene epitope.
The Journal of experimental medicine 1984;160(6):1925-30.
1984: B T Huber; Paula S Hochman
B cell activation potential of insulin-reactive T cells in H-2b mice.
European journal of immunology 1984;14(12):1106-10.
1984: Paula S Hochman; B T Huber
Immune recognition of insulin by H-2b mice: the mutation in the I-Ab beta gene of the B6.C-H-2bm12 mouse alters the self-I-A-restricted T cell repertoire.
European journal of immunology 1984;14(7):610-5.