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Dana Hocková

Research Profile

Chemicals & Drugs

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Cell Line

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Vaccinia

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Publications

TOP 3
Dianne T Keough; Lieve Naesens; Lenka Slavětínská; Tomáš Tichý; Silvie Vrbková; Tzu-Hsuan Wang; Petr Špaček; Marina Chavchich; John de Jersey; Michael D Edstein; Dana Hocková; Zlatko Janeba; Luke W Guddat
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
Dana Hocková; Zlatko Janeba; Dianne T Keough; Tzu-Hsuan Wang; John de Jersey; Luke W Guddat
Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.
Marcela Krečmerová; Martin Dračínský; Dana Hocková; Antonín Holý; Dianne T Keough; Luke W Guddat
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.

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All Publications

2013: Dianne T Keough; Lieve Naesens; Lenka Slavětínská; Tomáš Tichý; Silvie Vrbková; Tzu-Hsuan Wang; Petr Špaček; Marina Chavchich; John de Jersey; Michael D Edstein; Dana Hocková; Zlatko Janeba; Luke W Guddat
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
Journal of medicinal chemistry 2013;56(6):2513-26.
2012: Dana Hocková; Zlatko Janeba; Dianne T Keough; Tzu-Hsuan Wang; John de Jersey; Luke W Guddat
Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases.
Journal of medicinal chemistry 2012;55(13):6209-23.
2012: Marcela Krečmerová; Martin Dračínský; Dana Hocková; Antonín Holý; Dianne T Keough; Luke W Guddat
Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents.
Bioorganic & medicinal chemistry 2012;20(3):1222-30.
2012: Michal Cesnek; John de Jersey; Ondřej Baszczyňski; Martin Dračínský; Dana Hocková; Antonín Holý; Dianne T Keough; Luke W Guddat
Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
Bioorganic & medicinal chemistry 2012;20(2):1076-89.
2011: Dana Hocková; Antonín Holý; Robert Snoeck; Graciela Andrei; Jan Balzarini
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity.
Bioorganic & medicinal chemistry 2011;19(15):4445-53.
2011: John de Jersey; Dana Hocková; Antonín Holý; Dianne T Keough; Lieve Naesens; Luke W Guddat
6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs.
Current topics in medicinal chemistry 2011;11(16):2085-102.
2010: Dianne T Keough; Dana Hocková; Marcela Krecmerová; Michal Cesnek; Antonín Holý; Lieve Naesens; Ian M Brereton; Donald J Winzor; John de Jersey; Luke W Guddat
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy.
Molecular and biochemical parasitology 2010;173(2):165-9.
2009: Dana Hocková; Antonín Holý; Milena Masojídková; Dianne T Keough; John de Jersey; Luke W Guddat
Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Bioorganic & medicinal chemistry 2009;17(17):6218-32.
2009: Dianne T Keough; Dana Hocková; Antonín Holý; Lieve M J Naesens; Tina S Skinner-Adams; John de Jersey; Luke W Guddat
Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.
Journal of medicinal chemistry 2009;52(14):4391-9.
2007: Jan Balzarini; Dominique Schols; Kristel Van Laethem; Erik De Clercq; Dana Hocková; Milina Masojidkova; Antonín Holý
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
The Journal of antimicrobial chemotherapy 2007;59(1):80-6.
2005: Chunxiao Ying; A Holy; Dana Hocková; Z Havlas; Erik De Clercq; Johan Neyts
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.
Antimicrobial agents and chemotherapy 2005;49(3):1177-80.
2005: Erik De Clercq; Graciela Andrei; Jan Balzarini; Pieter Leyssen; Lieve Naesens; Johan Neyts; Christophe Pannecouque; Robert Snoeck; Chunxiao Ying; Dana Hocková; Antonín Holý
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):331-41.
2004: Jan Balzarini; Christophe Pannecouque; Lieve Naesens; Graciela Andrei; Robert Snoeck; Erik De Clercq; Dana Hocková; Antonín Holý
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1321-7.
2004: Dana Hocková; Antonín Holý; Milena Masojídková; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compounds.
Bioorganic & medicinal chemistry 2004;12(12):3197-202.
2003: Dana Hocková; Antonín Holý; Milena Masojídková; Graciela Andrei; Robert Snoeck; Erik De Clercq; Jan Balzarini
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
Journal of medicinal chemistry 2003;46(23):5064-73.