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David Hodge

Research Profile

Concepts & Ideas

Molecular Sequence Data

Chemicals & Drugs

Disorders

Multiple Myeloma

Physiology

Genes & Molecular Sequences

Amino Acid Sequences

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Tumor Cell Line

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Publications

TOP 3
David R Hodge; Edward Cho; Terry D Copeland; Tad Guszczynski; Eric Yang; Arun K Seth; William L Farrar
IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase.
Benjamin Peng; Elaine M Hurt; David R Hodge; Suneetha B Thomas; William L Farrar
DNA hypermethylation and partial gene silencing of human thymine- DNA glycosylase in multiple myeloma cell lines.
David R Hodge; Elaine M Hurt; William L Farrar
The role of IL-6 and STAT3 in inflammation and cancer.

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2007: David R Hodge; Edward Cho; Terry D Copeland; Tad Guszczynski; Eric Yang; Arun K Seth; William L Farrar
IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase.
Cancer genomics & proteomics 2007;4(6):387-98.
2006: Benjamin Peng; Elaine M Hurt; David R Hodge; Suneetha B Thomas; William L Farrar
DNA hypermethylation and partial gene silencing of human thymine- DNA glycosylase in multiple myeloma cell lines.
Epigenetics : official journal of the DNA Methylation Society 2006;1(3):138-45.
2005: David R Hodge; Elaine M Hurt; William L Farrar
The role of IL-6 and STAT3 in inflammation and cancer.
European journal of cancer (Oxford, England : 1990) 2005;41(16):2502-12.
2005: David R Hodge; Weihua Xiao; Benjamin Peng; James C Cherry; David J Munroe; William L Farrar
Enforced expression of superoxide dismutase 2/manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis.
Cancer research 2005;65(14):6255-63.
2005: David R Hodge; Benjamin Peng; James C Cherry; Elaine M Hurt; Stephen D Fox; James A Kelley; David J Munroe; William L Farrar
Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation.
Cancer research 2005;65(11):4673-82.
2005: David R Hodge; Benjamin Peng; Celine Pompeia; Suneetha Thomas; Edward Cho; Peter Clausen; Victor E Marquez; William L Farrar
Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferation.
Cancer biology & therapy 2005;4(5):585-92.
2005: Benjamin Peng; David R Hodge; Suneetha B Thomas; James M Cherry; David J Munroe; Celine Pompeia; Weihua Xiao; William L Farrar
Epigenetic silencing of the human nucleotide excision repair gene, hHR23B, in interleukin-6-responsive multiple myeloma KAS-6/1 cells.
The Journal of biological chemistry 2005;280(6):4182-7.
2004: Weihua Xiao; David R Hodge; Lihua Wang; Xiaoyi Yang; Xiaohu Zhang; William L Farrar
Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta (C/EBP-beta) regulate the IL-6 promoter in autocrine human prostate cancer cells.
The Prostate 2004;61(4):354-70.
2004: Weihua Xiao; David R Hodge; Lihua Wang; Xiaoyi Yang; Xiaohu Zhang; William L Farrar
NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells.
Cancer biology & therapy 2004;3(10):1007-17.
2004: Carole Galligan; Wataru Matsuyama; Akihiro Matsukawa; Hiroshi Mizuta; David R Hodge; O M Zack Howard; Teizo Yoshimura
Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis.
Arthritis and rheumatism 2004;50(6):1806-14.
2004: Celine Pompeia; David R Hodge; Christoph Plass; Yue-Zhong Wu; Victor E Marquez; James A Kelley; William L Farrar
Microarray analysis of epigenetic silencing of gene expression in the KAS-6/1 multiple myeloma cell line.
Cancer research 2004;64(10):3465-73.
2004: David R Hodge; Weihua Xiao; Li Hua Wang; Dapei Li; William L Farrar
Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells.
Cancer biology & therapy 2004;3(2):188-94.
2002: David R Hodge; Dapei Li; Sheng Mei Qi; William L Farrar
IL-6 induces expression of the Fli-1 proto-oncogene via STAT3.
Biochemical and biophysical research communications 2002;292(1):287-91.
2001: David R Hodge; W Xiao; Peter Clausen; Gisela Heidecker; M Szyf; William L Farrar
Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells.
The Journal of biological chemistry 2001;276(43):39508-11.
2000: David R Hodge; Peter Clausen
Transcriptional activation analysis using bioluminescent reporter assays.
Molecular biotechnology 2000;16(1):67-76.
2000: X Y Yang; L H Wang; Taosheng Chen; David R Hodge; James Resau; L DaSilva; William L Farrar
Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT.
The Journal of biological chemistry 2000;275(7):4541-4.
1998: David R Hodge; K J Dunn; G K Pei; M K Chakrabarty; Gisela Heidecker; J A Lautenberger; K P Samuel
Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein.
The Journal of biological chemistry 1998;273(25):15727-33.
1998: Gisela Heidecker; H Muñoz; Patricia A Lloyd; David R Hodge; G K Pei; S W Rick; K Brehm; F W Ruscetti; Lewis H Kuller; Patricia Polacino; Shiu-Lok Hu; William R Morton; Raoul E Benveniste
Sequence diversity of SIV(Mne) Nef in vivo and in vitro.
Journal of medical primatology 1998;27(2-3):73-80.
1996: M C Venanzoni; L R Robinson; David R Hodge; I Kola; Arun Seth
ETS1 and ETS2 in p53 regulation: spatial separation of ETS binding sites (EBS) modulate protein: DNA interaction.
Oncogene 1996;12(6):1199-1204.
1996: David R Hodge; L Robinson; Dennis Watson; J Lautenberger; Xian-Kui John Zhang; M Venanzoni; Arun Seth
Interaction of ETS-1 and ERGB/FLI-1 proteins with DNA is modulated by spacing between multiple binding sites as well as phosphorylation.
Oncogene 1996;12(1):11-8.
1995: David R Hodge; D M Thompson; A Panayiotakis; Arun Seth
Transcriptional activation analysis by the chloramphenicol acetyl transferase (CAT) enzyme assay.
Methods in molecular biology (Clifton, N.J.) 1995;37():409-21.
1995: David R Hodge; Y M Chen; K P Samuel
Oligomerization of the HIV type 2 Nef protein: mutational analysis of the heptad leucine repeat motif and cysteine residues.
AIDS research and human retroviruses 1995;11(1):65-79.
1994: H Li; David R Hodge; G K Pei; Arun Seth
Isolation and sequence analysis of the human syntaxin-encoding gene.
Gene 1994;143(2):303-4.
1994: Arun Seth; L Robinson; A Panayiotakis; D M Thompson; David R Hodge; Xian-Kui John Zhang; Dennis Watson; K Ozato; TS Papas
The EndoA enhancer contains multiple ETS binding site repeats and is regulated by ETS proteins.
Oncogene 1994;9(2):469-77.
1993: G C Du Bois; David R Hodge; C A Hanson; K P Samuel; M Zweig; S D Showalter; TS Papas
Purification of an Escherichia coli-expressed Nef protein from the human immunodeficiency virus-type 2.
AIDS research and human retroviruses 1993;9(12):1225-31.
1993: Arun Seth; David R Hodge; D M Thompson; L Robinson; A Panayiotakis; Dennis Watson; TS Papas
ETS family proteins activate transcription from HIV-1 long terminal repeat.
AIDS research and human retroviruses 1993;9(10):1017-23.
1991: K P Samuel; David R Hodge; Y M Chen; TS Papas
Nef proteins of the human immunodeficiency viruses (HIV-1 and HIV-2) and simian immunodeficiency virus (SIV) are structurally similar to leucine zipper transcriptional activation factors.
AIDS research and human retroviruses 1991;7(8):697-706.
1990: M Zweig; K P Samuel; S D Showalter; S V Bladen; G C DuBois; J A Lautenberger; David R Hodge; TS Papas
Heterogeneity of Nef proteins in cells infected with human immunodeficiency virus type 1.
Virology 1990;179(1):504-7.