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Robert Hodges

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Colin T Mant; Ziqing Jiang; Barry E Boyes; Robert S Hodges
An improved approach to hydrophilic interaction chromatography of peptides: salt gradients in the presence of high isocratic acetonitrile concentrations.
Colin T Mant; Robert S Hodges
Design of peptide standards with the same composition and minimal sequence variation to monitor performance/selectivity of reversed-phase matrices.
Miguel A Lanaspa; Nanxing Li; Colin T Mant; Christopher J Rivard; Carlos A Roncal-Jimenez; Laura G Sánchez-Lozada; Jeffrey Thomas; Ana Andrés-Hernando; Christina Cicerchi; Gabriela Garcia; Robert S Hodges; Brandi Hunter; Takuji Ishimoto; Richard J Johnson
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver.

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All Publications

2013: Colin T Mant; Ziqing Jiang; Barry E Boyes; Robert S Hodges
An improved approach to hydrophilic interaction chromatography of peptides: salt gradients in the presence of high isocratic acetonitrile concentrations.
Journal of chromatography. A 2013;1277():15-25.
2012: Colin T Mant; Robert S Hodges
Design of peptide standards with the same composition and minimal sequence variation to monitor performance/selectivity of reversed-phase matrices.
Journal of chromatography. A 2012;1230():30-40.
2012: Miguel A Lanaspa; Nanxing Li; Colin T Mant; Christopher J Rivard; Carlos A Roncal-Jimenez; Laura G Sánchez-Lozada; Jeffrey Thomas; Ana Andrés-Hernando; Christina Cicerchi; Gabriela Garcia; Robert S Hodges; Brandi Hunter; Takuji Ishimoto; Richard J Johnson
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver.
PloS one 2012;7(11):e48801.
2012: Sheryl Zajdowicz; Mark W Duncan; Jon C Haller; Robert S Hodges; Stephen W Hunsucker; David N M Jones; Amy E Krafft; Colin T Mant; Randall K Holmes
Purification and structural characterization of siderophore (corynebactin) from Corynebacterium diphtheriae.
PloS one 2012;7(4):e34591.
2011: Ziqing Jiang; Adriana I Vasil; Lajos Gera; Michael L Vasil; Robert S Hodges
Rational design of α-helical antimicrobial peptides to target Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: utilization of charge, 'specificity determinants,' total hydrophobicity, hydrophobe type and location as design parameters to improve the therapeutic ratio.
Chemical biology & drug design 2011;77(4):225-40.
2011: Ziqing Jiang; Michael P Higgins; James Whitehurst; Kevin O Kisich; Martin I Voskuil; Robert S Hodges
Anti-tuberculosis activity of α-helical antimicrobial peptides: de novo designed L- and D-enantiomers versus L- and D-LL-37.
Protein and peptide letters 2011;18(3):241-52.
2011: Heidi K Baumgartner; Neal Beeman; Robert S Hodges; Margaret C. Neville
A D-peptide analog of the second extracellular loop of claudin-3 and -4 leads to mislocalized claudin and cellular apoptosis in mammary epithelial cells.
Chemical biology & drug design 2011;77(2):124-36.
2010: Colin T Mant; Dziuleta Cepeniene; Robert S Hodges
Reversed-phase HPLC of peptides: Assessing column and solvent selectivity on standard, polar-embedded and polar endcapped columns.
Journal of separation science 2010;33(19):3005-21.
2010: Clifton Hackbarth; Robert S Hodges
Synthetic peptide vaccine development: designing dual epitopes into a single pilin peptide immunogen generates antibody cross-reactivity between two strains of Pseudomonas aeruginosa.
Chemical biology & drug design 2010;76(4):293-304.
2010: J Paul Kirwan; Robert S Hodges
Critical interactions in the stability control region of tropomyosin.
Journal of structural biology 2010;170(2):294-306.
2009: Robert S Hodges; Janine Mills; Susanna McReynolds; J Paul Kirwan; Brian Tripet; David Osguthorpe
Identification of a unique "stability control region" that controls protein stability of tropomyosin: A two-stranded alpha-helical coiled-coil.
Journal of molecular biology 2009;392(3):747-62.
2009: Daniel J Kao; Robert S Hodges
Advantages of a synthetic peptide immunogen over a protein immunogen in the development of an anti-pilus vaccine for Pseudomonas aeruginosa.
Chemical biology & drug design 2009;74(1):33-42.
2009: Masood Jelokhani-Niaraki; Leslie H Kondejewski; Laura C Wheaton; Robert S Hodges
Effect of ring size on conformation and biological activity of cyclic cationic antimicrobial peptides.
Journal of medicinal chemistry 2009;52(7):2090-7.
2009: Colin T Mant; James M Kovacs; Hyun-Min Kim; David D Pollock; Robert S Hodges
Intrinsic amino acid side-chain hydrophilicity/hydrophobicity coefficients determined by reversed-phase high-performance liquid chromatography of model peptides: comparison with other hydrophilicity/hydrophobicity scales.
Biopolymers 2009;92(6):573-95.
2009: Ziqing Jiang; Adriana I Vasil; John Hale; Robert E W Hancock; Michael L Vasil; Robert S Hodges
Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.
Advances in experimental medicine and biology 2009;611():561-2.
2009: Zhe Yan; Kathryn V Holmes; Robert S Hodges
Expression and characterization of recombinant S2 subunit of SARS-coronavirus S fusion protein.
Advances in experimental medicine and biology 2009;611():153-4.
2009: J Paul Kirwan; Stan C Kwok; Susanna McReynolds; Janine Mills; David Osguthorpe; Robert S Hodges
Unique role of clusters of electrostatic attractions in controlling the stability of two-stranded alpha-helical coiled-coils.
Advances in experimental medicine and biology 2009;611():77-8.
2008: Masood Jelokhani-Niaraki; Robert S Hodges; Joseph E Meissner; Una E Hassenstein; Laura Wheaton
Interaction of gramicidin S and its aromatic amino-acid analog with phospholipid membranes.
Biophysical journal 2008;95(7):3306-21.
2008: Bin Yu; Elisabeth M Davis; Robert S Hodges; Randall T Irvin; D Y Li
Surface nanocrystallization of stainless steel for reduced biofilm adherence.
Nanotechnology 2008;19(33):335101.
2008: Colin T Mant; Robert S Hodges
Mixed-mode hydrophilic interaction/cation-exchange chromatography (HILIC/CEX) of peptides and proteins.
Journal of separation science 2008;31(15):2754-73.
2008: Colin T Mant; Robert S Hodges
Mixed-mode hydrophilic interaction/cation-exchange chromatography: separation of complex mixtures of peptides of varying charge and hydrophobicity.
Journal of separation science 2008;31(9):1573-84.
2008: Ziqing Jiang; Adriana I Vasil; John D Hale; Robert E W Hancock; Michael Vasil; Robert S Hodges
Effects of net charge and the number of positively charged residues on the biological activity of amphipathic alpha-helical cationic antimicrobial peptides.
Biopolymers 2008;90(3):369-83.
2007: Daniel J Kao; Mair E A Churchill; Randall T Irvin; Robert S Hodges
Animal protection and structural studies of a consensus sequence vaccine targeting the receptor binding domain of the type IV pilus of Pseudomonas aeruginosa.
Journal of molecular biology 2007;374(2):426-42.
2007: Thomas Abraham; Seema Marwaha; Daniel M Kobewka; Ruthven N A H Lewis; Elmar J Prenner; Robert S Hodges; Ronald N McElhaney
The relationship between the binding to and permeabilization of phospholipid bilayer membranes by GS14dK4, a designed analog of the antimicrobial peptide gramicidin S.
Biochimica et biophysica acta 2007;1768(9):2089-98.
2007: Traian V Popa; Colin T Mant; Robert S Hodges
Ion-interaction CZE: the presence of high concentrations of ion-pairing reagents demonstrates the complex mechanisms involved in peptide separations.
Electrophoresis 2007;28(13):2181-90.
2007: Yuxin Chen; Michael T Guarnieri; Adriana I Vasil; Michael Vasil; Colin T Mant; Robert S Hodges
Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides.
Antimicrobial agents and chemotherapy 2007;51(4):1398-406.
2007: Brian Tripet; Dziuleta Cepeniene; James M Kovacs; Colin T Mant; Oleg Krokhin; Robert S Hodges
Requirements for prediction of peptide retention time in reversed-phase high-performance liquid chromatography: hydrophilicity/hydrophobicity of side-chains at the N- and C-termini of peptides are dramatically affected by the end-groups and location.
Journal of chromatography. A 2007;1141(2):212-25.
2007: Ruthven N A H Lewis; Feng Liu; Roland Krivanek; Peter Rybar; Tibor Hianik; Carol R Flach; Richard Mendelsohn; Y Chen; C T Mant; Robert S Hodges; Ronald N McElhaney
Studies of the minimum hydrophobicity of alpha-helical peptides required to maintain a stable transmembrane association with phospholipid bilayer membranes.
Biochemistry 2007;46(4):1042-54.
2007: Yuxin Chen; Colin T Mant; Robert S Hodges
Preparative reversed-phase high-performance liquid chromatography collection efficiency for an antimicrobial peptide on columns of varying diameters (1mm to 9.4mm I.D.).
Journal of chromatography. A 2007;1140(1-2):112-20.
2007: Colin T Mant; Yuxin Chen; Zhe Yan; Traian V Popa; James M Kovacs; Janine B Mills; Brian P Tripet; Robert S Hodges
HPLC analysis and purification of peptides.
Methods in molecular biology (Clifton, N.J.) 2007;386():3-55.
2006: Janine B Mills; Colin T Mant; Robert S Hodges
One-step purification of a recombinant protein from a whole cell extract by reversed-phase high-performance liquid chromatography.
Journal of chromatography. A 2006;1133(1-2):248-53.
2006: Colin T Mant; Robert S Hodges
Context-dependent effects on the hydrophilicity/hydrophobicity of side-chains during reversed-phase high-performance liquid chromatography: Implications for prediction of peptide retention behaviour.
Journal of chromatography. A 2006;1125(2):211-9.
2006: James M Kovacs; Colin T Mant; Stanley C Kwok; David J Osguthorpe; Robert S Hodges
Quantitation of the nearest-neighbour effects of amino acid side-chains that restrict conformational freedom of the polypeptide chain using reversed-phase liquid chromatography of synthetic model peptides with L- and D-amino acid substitutions.
Journal of chromatography. A 2006;1123(2):212-24.
2006: Zhe Yan; Brian Tripet; Robert S Hodges
Biophysical characterization of HRC peptide analogs interaction with heptad repeat regions of the SARS-coronavirus Spike fusion protein core.
Journal of structural biology 2006;155(2):162-75.
2006: Brian Tripet; Daniel J Kao; Scott A Jeffers; Kathryn V Holmes; Robert S Hodges
Template-based coiled-coil antigens elicit neutralizing antibodies to the SARS-coronavirus.
Journal of structural biology 2006;155(2):176-94.
2006: Traian V Popa; Colin T Mant; Robert S Hodges
Ion-interaction-capillary zone electrophoresis of cationic proteomic peptide standards.
Journal of chromatography. A 2006;1111(2):192-9.
2006: Yuxin Chen; Adriana I Vasil; Linda Rehaume; Colin T Mant; Jane L Burns; Michael Vasil; Robert E W Hancock; Robert S Hodges
Comparison of biophysical and biologic properties of alpha-helical enantiomeric antimicrobial peptides.
Chemical biology & drug design 2006;67(2):162-73.
2006: Carmen L Giltner; Erin J van Schaik; Gerald F Audette; Daniel J Kao; Robert S Hodges; Daniel J Hassett; Randall T Irvin
The Pseudomonas aeruginosa type IV pilin receptor binding domain functions as an adhesin for both biotic and abiotic surfaces.
Molecular microbiology 2006;59(4):1083-96.
2006: James M Kovacs; Colin T Mant; Robert S Hodges
Determination of intrinsic hydrophilicity/hydrophobicity of amino acid side chains in peptides in the absence of nearest-neighbor or conformational effects.
Biopolymers 2006;84(3):283-97.
2005: Thomas Abraham; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Isothermal titration calorimetry studies of the binding of the antimicrobial peptide gramicidin S to phospholipid bilayer membranes.
Biochemistry 2005;44(33):11279-85.
2005: M Shibue; Colin T Mant; Robert S Hodges
Effect of anionic ion-pairing reagent hydrophobicity on selectivity of peptide separations by reversed-phase liquid chromatography.
Journal of chromatography. A 2005;1080(1):68-75.
2005: M Shibue; Colin T Mant; Robert S Hodges
Effect of anionic ion-pairing reagent concentration (1-60 mM) on reversed-phase liquid chromatography elution behaviour of peptides.
Journal of chromatography. A 2005;1080(1):58-67.
2005: M Shibue; Colin T Mant; Robert S Hodges
The perchlorate anion is more effective than the trifluoroacetate anion as an ion-pairing reagent for reversed-phase chromatography of peptides.
Journal of chromatography. A 2005;1080(1):49-57.
2005: Yuxin Chen; Colin T Mant; Susan W Farmer; Robert E W Hancock; Michael Vasil; Robert S Hodges
Rational design of alpha-helical antimicrobial peptides with enhanced activities and specificity/therapeutic index.
The Journal of biological chemistry 2005;280(13):12316-29.
2005: Thomas Abraham; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Isothermal titration calorimetry studies of the binding of a rationally designed analogue of the antimicrobial peptide gramicidin s to phospholipid bilayer membranes.
Biochemistry 2005;44(6):2103-12.
2005: Elmar J Prenner; Monika Kiricsi; Masood Jelokhani-Niaraki; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Structure-activity relationships of diastereomeric lysine ring size analogs of the antimicrobial peptide gramicidin S: mechanism of action and discrimination between bacterial and animal cell membranes.
The Journal of biological chemistry 2005;280(3):2002-11.
2004: Darrin A Lindhout; Jennifer R Litowski; Pascal Mercier; Robert S Hodges; Brian D Sykes
NMR solution structure of a highly stable de novo heterodimeric coiled-coil.
Biopolymers 2004;75(5):367-75.
2004: Paul J Cachia; Daniel J Kao; Robert S Hodges
Synthetic peptide vaccine development: measurement of polyclonal antibody affinity and cross-reactivity using a new peptide capture and release system for surface plasmon resonance spectroscopy.
Journal of molecular recognition : JMR 2004;17(6):540-57.
2004: Robert S Hodges; Yuxin Chen; E Kopecky; Colin T Mant
Monitoring the hydrophilicity/hydrophobicity of amino acid side-chains in the non-polar and polar faces of amphipathic alpha-helices by reversed-phase and hydrophilic interaction/cation-exchange chromatography.
Journal of chromatography. A 2004;1053(1-2):161-72.
2004: Feng Liu; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylethanolamine Bilayers.
Biophysical journal 2004;87(4):2470-82.
2004: Traian V Popa; Colin T Mant; Yuxin Chen; Robert S Hodges
Capillary zone electrophoresis of alpha-helical diastereomeric peptide pairs with anionic ion-pairing reagents.
Journal of chromatography. A 2004;1043(1):113-22.
2004: Yuxin Chen; Colin T Mant; Robert S Hodges
Selectivity differences in the separation of amphipathic alpha-helical peptides during reversed-phase liquid chromatography at pHs 2.0 and 7.0: effects of different packings, mobile phase conditions and temperature.
Journal of chromatography. A 2004;1043(1):99-111.
2004: Yuxin Chen; A R Mehok; Colin T Mant; Robert S Hodges
Optimum concentration of trifluoroacetic acid for reversed-phase liquid chromatography of peptides revisited.
Journal of chromatography. A 2004;1043(1):9-18.
2004: Stanley C Kwok; Robert S Hodges
Stabilizing and destabilizing clusters in the hydrophobic core of long two-stranded alpha-helical coiled-coils.
The Journal of biological chemistry 2004;279(20):21576-88.
2004: Brian Tripet; Megan W Howard; Michael Jobling; Randall K Holmes; Kathryn V Holmes; Robert S Hodges
Structural characterization of the SARS-coronavirus spike S fusion protein core.
The Journal of biological chemistry 2004;279(20):20836-49.
2004: Traian V Popa; Colin T Mant; Robert S Hodges
Capillary electrophoresis of cationic random coil peptide standards: effect of anionic ion-pairing reagents and comparison with reversed-phase chromatography.
Electrophoresis 2004;25(9):1219-29.
2004: Feng Liu; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylglycerol bilayers.
Biochemistry 2004;43(12):3679-87.
2004: Stephen M Lu; Robert S Hodges
Defining the minimum size of a hydrophobic cluster in two-stranded alpha-helical coiled-coils: effects on protein stability.
Protein science : a publication of the Protein Society 2004;13(3):714-26.
2004: Darin L Lee; J-P S Powers; K Pflegerl; Michael Vasil; Robert E W Hancock; Robert S Hodges
Effects of single D-amino acid substitutions on disruption of beta-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S.
The journal of peptide research : official journal of the American Peptide Society 2004;63(2):69-84.
2004: Stanley C Kwok; Robert S Hodges
Effect of chain length on coiled-coil stability: decreasing stability with increasing chain length.
Biopolymers 2004;76(5):378-90.
2004: Traian V Popa; Colin T Mant; Robert S Hodges
Capillary electrophoresis of amphipathic alpha-helical peptide diastereomers.
Electrophoresis 2004;25(1):94-107.
2003: David L Zoetewey; Brian Tripet; Tatiana G Kutateladze; Michael Overduin; Janet M Wood; Robert S Hodges
Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP.
Journal of molecular biology 2003;334(5):1063-76.
2003: Traian V Popa; Colin T Mant; Robert S Hodges
Capillary electrophoresis of synthetic peptide standards varying in charge and hydrophobicity.
Electrophoresis 2003;24(24):4197-208.
2003: Stanley C Kwok; Robert S Hodges
Clustering of large hydrophobes in the hydrophobic core of two-stranded alpha-helical coiled-coils controls protein folding and stability.
The Journal of biological chemistry 2003;278(37):35248-54.
2003: Yuxin Chen; Colin T Mant; Robert S Hodges
Temperature selectivity effects in reversed-phase liquid chromatography due to conformation differences between helical and non-helical peptides.
Journal of chromatography. A 2003;1010(1):45-61.
2003: Colin T Mant; Brian Tripet; Robert S Hodges
Temperature profiling of polypeptides in reversed-phase liquid chromatography. II. Monitoring of folding and stability of two-stranded alpha-helical coiled-coils.
Journal of chromatography. A 2003;1009(1-2):45-59.
2003: Colin T Mant; Yuxin Chen; Robert S Hodges
Temperature profiling of polypeptides in reversed-phase liquid chromatography. I. Monitoring of dimerization and unfolding of amphipathic alpha-helical peptides.
Journal of chromatography. A 2003;1009(1-2):29-43.
2003: Darin L Lee; Sergei Ivaninskii; Peter Burkhard; Robert S Hodges
Unique stabilizing interactions identified in the two-stranded alpha-helical coiled-coil: crystal structure of a cortexillin I/GCN4 hybrid coiled-coil peptide.
Protein science : a publication of the Protein Society 2003;12(7):1395-405.
2003: Darin L Lee; Colin T Mant; Robert S Hodges
A novel method to measure self-association of small amphipathic molecules: temperature profiling in reversed-phase chromatography.
The Journal of biological chemistry 2003;278(25):22918-27.
2003: Gregory De Crescenzo; Jennifer R Litowski; Robert S Hodges; Maureen D O'Connor-McCourt
Real-time monitoring of the interactions of two-stranded de novo designed coiled-coils: effect of chain length on the kinetic and thermodynamic constants of binding.
Biochemistry 2003;42(6):1754-63.
2003: Ruthven N A H Lewis; Monika Kiricsi; Elmar J Prenner; Robert S Hodges; Ronald N McElhaney
Fourier transform infrared spectroscopic study of the interactions of a strongly antimicrobial but weakly hemolytic analogue of gramicidin S with lipid micelles and lipid bilayer membranes.
Biochemistry 2003;42(2):440-9.
2003: Paul J Cachia; Robert S Hodges
Synthetic peptide vaccine and antibody therapeutic development: prevention and treatment of Pseudomonas aeruginosa.
Biopolymers 2003;71(2):141-68.
2003: Darin L Lee; Robert S Hodges
Structure-activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S.
Biopolymers 2003;71(1):28-48.
2003: Brian Tripet; Gregory De Crescenzo; Suzanne Grothe; Maureen D O'Connor-McCourt; Robert S Hodges
Kinetic analysis of the interactions between troponin C (TnC) and troponin I (TnI) binding peptides: evidence for separate binding sites for the 'structural' N-terminus and the 'regulatory' C-terminus of TnI on TnC.
Journal of molecular recognition : JMR 2003;16(1):37-53.
2002: Monika Kiricsi; Elmar J Prenner; Masood Jelokhani-Niaraki; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
The effects of ring-size analogs of the antimicrobial peptide gramicidin S on phospholipid bilayer model membranes and on the growth of Acholeplasma laidlawii B.
European journal of biochemistry / FEBS 2002;269(23):5911-20.
2002: Brian Tripet; Gregory De Crescenzo; Suzanne Grothe; Maureen D O'Connor-McCourt; Robert S Hodges
Kinetic analysis of the interactions between troponin C and the C-terminal troponin I regulatory region and validation of a new peptide delivery/capture system used for surface plasmon resonance.
Journal of molecular biology 2002;323(2):345-62.
2002: Jennifer R Litowski; Robert S Hodges
Designing heterodimeric two-stranded alpha-helical coiled-coils. Effects of hydrophobicity and alpha-helical propensity on protein folding, stability, and specificity.
The Journal of biological chemistry 2002;277(40):37272-9.
2002: Colin T Mant; Robert S Hodges
Preparative reversed-phase liquid chromatography of proteins from rabbit skeletal troponin, a multi-protein complex.
Journal of chromatography. A 2002;972(1):101-14.
2002: Anthony R Mehok; Colin T Mant; Lajos Gera; John Stewart; Robert S Hodges
Preparative reversed-phase liquid chromatography of peptides. Isocratic two-step elution system for high loads on analytical columns.
Journal of chromatography. A 2002;972(1):87-99.
2002: Colin T Mant; Robert S Hodges
Reversed-phase liquid chromatography as a tool in the determination of the hydrophilicity/hydrophobicity of amino acid side-chains at a ligand-receptor interface in the presence of different aqueous environments. II. Effect of varying peptide ligand hydrophobicity.
Journal of chromatography. A 2002;972(1):61-75.
2002: Colin T Mant; Robert S Hodges
Reversed-phase liquid chromatography as a tool in the determination of the hydrophilicity/hydrophobicity of amino acid side-chains at a ligand-receptor interface in the presence of different aqueous environments. I. Effect of varying receptor hydrophobicity.
Journal of chromatography. A 2002;972(1):45-60.
2002: Feng Liu; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Effect of variations in the structure of a polyleucine-based alpha-helical transmembrane peptide on its interaction with phosphatidylcholine bilayers.
Biochemistry 2002;41(29):9197-207.
2002: Masood Jelokhani-Niaraki; Elmar J Prenner; Cyril M Kay; Ronald N McElhaney; Robert S Hodges
Conformation and interaction of the cyclic cationic antimicrobial peptides in lipid bilayers.
The journal of peptide research : official journal of the American Peptide Society 2002;60(1):23-36.
2002: Stephen M Lu; Robert S Hodges
A de novo designed template for generating conformation-specific antibodies that recognize alpha-helices in proteins.
The Journal of biological chemistry 2002;277(26):23515-24.
2002: Stanley C Kwok; Colin T Mant; Robert S Hodges
Importance of secondary structural specificity determinants in protein folding: insertion of a native beta-sheet sequence into an alpha-helical coiled-coil.
Protein science : a publication of the Protein Society 2002;11(6):1519-31.
2002: Alan C Gibbs; Trent C Bjorndahl; Robert S Hodges; David S Wishart
Probing the structural determinants of type II' beta-turn formation in peptides and proteins.
Journal of the American Chemical Society 2002;124(7):1203-13.
2002: Leslie H Kondejewski; Darin L Lee; Masood Jelokhani-Niaraki; Susan W Farmer; Robert E W Hancock; Robert S Hodges
Optimization of microbial specificity in cyclic peptides by modulation of hydrophobicity within a defined structural framework.
The Journal of biological chemistry 2002;277(1):67-74.
2002: Brian Tripet; Robert S Hodges
Helix capping interactions stabilize the N-terminus of the kinesin neck coiled-coil.
Journal of structural biology 2002;137(1-2):220-35.
2002: Mundeep Chana; Brian Tripet; Colin T Mant; Robert S Hodges
The role of unstructured highly charged regions on the stability and specificity of dimerization of two-stranded alpha-helical coiled-coils: analysis of the neck-hinge region of the kinesin-like motor protein Kif3A.
Journal of structural biology 2002;137(1-2):206-19.
2002: Y Chen; Colin T Mant; Robert S Hodges
Determination of stereochemistry stability coefficients of amino acid side-chains in an amphipathic alpha-helix.
The journal of peptide research : official journal of the American Peptide Society 2002;59(1):18-33.
2001: Jennifer R Litowski; Robert S Hodges
Designing heterodimeric two-stranded alpha-helical coiled-coils: the effect of chain length on protein folding, stability and specificity.
The journal of peptide research : official journal of the American Peptide Society 2001;58(6):477-92.
2001: Jason Baardsnes; Masood Jelokhani-Niaraki; Leslie H Kondejewski; Michael Kuiper; Cyril M Kay; Robert S Hodges; Peter L Davies
Antifreeze protein from shorthorn sculpin: identification of the ice-binding surface.
Protein science : a publication of the Protein Society 2001;10(12):2566-76.
2001: J Salgado; Stephan L Grage; Leslie H Kondejewski; Robert S Hodges; Ronald N McElhaney; Anne S Ulrich
Membrane-bound structure and alignment of the antimicrobial beta-sheet peptide gramicidin S derived from angular and distance constraints by solid state 19F-NMR.
Journal of biomolecular NMR 2001;21(3):191-208.
2001: Ruthven N A H Lewis; Yuanpeng Zhang; Robert S Hodges; Witold K Subczynski; Akihiro Kusumi; Carol R Flach; Richard Mendelsohn; Ronald N McElhaney
A polyalanine-based peptide cannot form a stable transmembrane alpha-helix in fully hydrated phospholipid bilayers.
Biochemistry 2001;40(40):12103-11.
2001: Masood Jelokhani-Niaraki; Elmar J Prenner; Leslie H Kondejewski; Cyril M Kay; Ronald N McElhaney; Robert S Hodges
Conformation and other biophysical properties of cyclic antimicrobial peptides in aqueous solutions.
The journal of peptide research : official journal of the American Peptide Society 2001;58(4):293-306.
2001: Tharin M A Blumenschein; Brian Tripet; Robert S Hodges; Brian D Sykes
Mapping the interacting regions between troponins T and C. Binding of TnT and TnI peptides to TnC and NMR mapping of the TnT-binding site on TnC.
The Journal of biological chemistry 2001;276(39):36606-12.
2001: S M Ngai; Joyce R Pearlstone; Lawrence B Smillie; Robert S Hodges
Characterization of the biologically important interaction between troponin C and the N-terminal region of troponin I.
Journal of cellular biochemistry 2001;83(1):99-110.
2001: S M Ngai; Joyce R Pearlstone; Chuck S Farah; Fernando C Reinach; Lawrence B Smillie; Robert S Hodges
Structural and functional studies on Troponin I and Troponin C interactions.
Journal of cellular biochemistry 2001;83(1):33-46.
2001: Darin L Lee; P Lavigne; Robert S Hodges
Are trigger sequences essential in the folding of two-stranded alpha-helical coiled-coils?
Journal of molecular biology 2001;306(3):539-53.
2001: Elmar J Prenner; Ruthven N A H Lewis; Masood Jelokhani-Niaraki; Robert S Hodges; Ronald N McElhaney
Cholesterol attenuates the interaction of the antimicrobial peptide gramicidin S with phospholipid bilayer membranes.
Biochimica et biophysica acta 2001;1510(1-2):83-92.
2001: Feng Liu; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
A differential scanning calorimetric and 31P NMR spectroscopic study of the effect of transmembrane alpha-helical peptides on the lamellar-reversed hexagonal phase transition of phosphatidylethanolamine model membranes.
Biochemistry 2001;40(3):760-8.
2001: Yuanpeng Zhang; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Peptide models of the helical hydrophobic transmembrane segments of membrane proteins: interactions of acetyl-K2-(LA)12-K2-amide with phosphatidylethanolamine bilayer membranes.
Biochemistry 2001;40(2):474-82.
2000: D L Husband; Colin T Mant; Robert S Hodges
Development of simultaneous purification methodology for multiple synthetic peptides by reversed-phase sample displacement chromatography.
Journal of chromatography. A 2000;893(1):81-94.
2000: Y B Yu; KC Wagschal; Colin T Mant; Robert S Hodges
Trapping the monomeric alpha-helical state during unfolding of coiled-coils by reversed-phase liquid chromatography.
Journal of chromatography. A 2000;890(1):81-94.
2000: Masood Jelokhani-Niaraki; Leslie H Kondejewski; Susan W Farmer; Robert E W Hancock; Cyril M Kay; Robert S Hodges
Diastereoisomeric analogues of gramicidin S: structure, biologicalactivity and interaction with lipid bilayers.
The Biochemical journal 2000;349 Pt 3():747-55.
2000: Brian Tripet; KC Wagschal; P Lavigne; Colin T Mant; Robert S Hodges
Effects of side-chain characteristics on stability and oligomerization state of a de novo-designed model coiled-coil: 20 amino acid substitutions in position "d".
Journal of molecular biology 2000;300(2):377-402.
2000: C McInnes; Leslie H Kondejewski; Robert S Hodges; Brian D Sykes
Development of the structural basis for antimicrobial and hemolytic activities of peptides based on gramicidin S and design of novel analogs using NMR spectroscopy.
The Journal of biological chemistry 2000;275(19):14287-94.
1999: Jason Baardsnes; Leslie H Kondejewski; Robert S Hodges; H Chao; C Kay; Peter L Davies
New ice-binding face for type I antifreeze protein.
FEBS letters 1999;463(1-2):87-91.
1999: Ruthven N A H Lewis; Elmar J Prenner; Leslie H Kondejewski; Carol R Flach; Richard Mendelsohn; Robert S Hodges; Ronald N McElhaney
Fourier transform infrared spectroscopic studies of the interaction of the antimicrobial peptide gramicidin S with lipid micelles and with lipid monolayer and bilayer membranes.
Biochemistry 1999;38(46):15193-203.
1999: KC Wagschal; Brian Tripet; P Lavigne; Colin T Mant; Robert S Hodges
The role of position a in determining the stability and oligomerization state of alpha-helical coiled coils: 20 amino acid stability coefficients in the hydrophobic core of proteins.
Protein science : a publication of the Protein Society 1999;8(11):2312-29.
1999: Jennifer R Litowski; Paul Semchuk; Colin T Mant; Robert S Hodges
Hydrophilic interaction/cation-exchange chromatography for the purification of synthetic peptides from closely related impurities: serine side-chain acetylated peptides.
The journal of peptide research : official journal of the American Peptide Society 1999;54(1):1-11.
1999: Leslie H Kondejewski; Masood Jelokhani-Niaraki; Susan W Farmer; Bruce Lix; Cyril M Kay; Brian D Sykes; Robert E W Hancock; Robert S Hodges
Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity.
The Journal of biological chemistry 1999;274(19):13181-92.
1999: MC Loewen; H Chao; ME Houston; Jason Baardsnes; Robert S Hodges; Cyril M Kay; Brian D Sykes; FD Sönnichsen; Peter L Davies
Alternative roles for putative ice-binding residues in type I antifreeze protein.
Biochemistry 1999;38(15):4743-9.
1999: Elmar J Prenner; Ruthven N A H Lewis; Leslie H Kondejewski; Robert S Hodges; Ronald N McElhaney
Differential scanning calorimetric study of the effect of the antimicrobial peptide gramicidin S on the thermotropic phase behavior of phosphatidylcholine, phosphatidylethanolamine and phosphatidylglycerol lipid bilayer membranes.
Biochimica et biophysica acta 1999;1417(2):211-23.
1999: KC Wagschal; Brian Tripet; Robert S Hodges
De novo design of a model peptide sequence to examine the effects of single amino acid substitutions in the hydrophobic core on both stability and oligomerization state of coiled-coils.
Journal of molecular biology 1999;285(2):785-803.
1998: WD Kohn; Cyril M Kay; Robert S Hodges
Orientation, positional, additivity, and oligomerization-state effects of interhelical ion pairs in alpha-helical coiled-coils.
Journal of molecular biology 1998;283(5):993-1012.
1998: PJ Cachia; L M Glasier; R R Hodgins; Wah Y Wong; Randall T Irvin; Robert S Hodges
The use of synthetic peptides in the design of a consensus sequence vaccine for Pseudomonas aeruginosa.
The journal of peptide research : official journal of the American Peptide Society 1998;52(4):289-99.
1998: H Chao; Daisy L Bautista; Jennifer R Litowski; Randall T Irvin; Robert S Hodges
Use of a heterodimeric coiled-coil system for biosensor application and affinity purification.
Journal of chromatography. B, Biomedical sciences and applications 1998;715(1):307-29.
1998: Colin T Mant; Jennifer R Litowski; Robert S Hodges
Hydrophilic interaction/cation-exchange chromatography for separation of amphipathic alpha-helical peptides.
Journal of chromatography. A 1998;816(1):65-78.
1998: P Lavigne; Matthew Crump; Stéphane M Gagné; Robert S Hodges; Cyril M Kay; Brian D Sykes
Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.
Journal of molecular biology 1998;281(1):165-81.
1998: M E Houston; Leslie H Kondejewski; D N Karunaratne; M Gough; S Fidai; Robert S Hodges; Robert E W Hancock
Influence of preformed alpha-helix and alpha-helix induction on the activity of cationic antimicrobial peptides.
The journal of peptide research : official journal of the American Peptide Society 1998;52(2):81-8.
1998: R E Bishop; Brenda K Leskiw; Robert S Hodges; Cyril M Kay; Joel Weiner
The entericidin locus of Escherichia coli and its implications for programmed bacterial cell death.
Journal of molecular biology 1998;280(4):583-96.
1998: ME Houston; H Chao; Robert S Hodges; Brian D Sykes; Cyril M Kay; FD Sönnichsen; MC Loewen; Peter L Davies
Binding of an oligopeptide to a specific plane of ice.
The Journal of biological chemistry 1998;273(19):11714-8.
1998: Alan C Gibbs; Leslie H Kondejewski; W Gronwald; Alex M Nip; Robert S Hodges; Brian D Sykes; David S Wishart
Unusual beta-sheet periodicity in small cyclic peptides.
Nature structural biology 1998;5(4):284-8.
1998: Witold K Subczynski; Ruthven N A H Lewis; Ronald N McElhaney; Robert S Hodges; James S Hyde; Akihiro Kusumi
Molecular organization and dynamics of 1-palmitoyl-2-oleoylphosphatidylcholine bilayers containing a transmembrane alpha-helical peptide.
Biochemistry 1998;37(9):3156-64.
1998: Stanley C Kwok; Brian Tripet; Jeremy Man; Mundeep Chana; P Lavigne; Colin T Mant; Robert S Hodges
Structural cassette mutagenesis in a de novo designed protein: proof of a novel concept for examining protein folding and stability.
Biopolymers 1998;47(1):101-23.
1998: WD Kohn; Cyril M Kay; Robert S Hodges
Effects of lanthanide binding on the stability of de novo designed alpha-helical coiled-coils.
The journal of peptide research : official journal of the American Peptide Society 1998;51(1):9-18.
1997: Colin T Mant; H Chao; Robert S Hodges
Effect of mobile phase on the oligomerization state of alpha-helical coiled-coil peptides during high-performance size-exclusion chromatography.
Journal of chromatography. A 1997;791(1-2):85-98.
1997: H Chao; ME Houston; Robert S Hodges; Cyril M Kay; Brian D Sykes; MC Loewen; Peter L Davies; FD Sönnichsen
A diminished role for hydrogen bonds in antifreeze protein binding to ice.
Biochemistry 1997;36(48):14652-60.
1997: Ryan T McKay; Brian Tripet; Robert S Hodges; Brian D Sykes
Interaction of the second binding region of troponin I with the regulatory domain of skeletal muscle troponin C as determined by NMR spectroscopy.
The Journal of biological chemistry 1997;272(45):28494-500.
1997: A Patricia Campbell; Daisy L Bautista; Brian Tripet; Wah Y Wong; Randall T Irvin; Robert S Hodges; Brian D Sykes
Solution secondary structure of a bacterially expressed peptide from the receptor binding domain of Pseudomonas aeruginosa pili strain PAK: A heteronuclear multidimensional NMR study.
Biochemistry 1997;36(42):12791-801.
1997: Brian Tripet; Jennifer E Van Eyk; Robert S Hodges
Mapping of a second actin-tropomyosin and a second troponin C binding site within the C terminus of troponin I, and their importance in the Ca2+-dependent regulation of muscle contraction.
Journal of molecular biology 1997;271(5):728-50.
1997: T J Sereda; Colin T Mant; Robert S Hodges
Use of sodium perchlorate at low pH for peptide separations by reversed-phase liquid chromatography. Influence of perchlorate ion on apparent hydrophilicity of positively charged amino acid side-chains.
Journal of chromatography. A 1997;776(1):153-65.
1997: Elmar J Prenner; Ruthven N A H Lewis; K C Neuman; Sol M Gruner; Leslie H Kondejewski; Robert S Hodges; Ronald N McElhaney
Nonlamellar phases induced by the interaction of gramicidin S with lipid bilayers. A possible relationship to membrane-disrupting activity.
Biochemistry 1997;36(25):7906-16.
1997: WD Kohn; Cyril M Kay; Robert S Hodges
Positional dependence of the effects of negatively charged Glu side chains on the stability of two-stranded alpha-helical coiled-coils.
Journal of peptide science : an official publication of the European Peptide Society 1997;3(3):209-23.
1997: Jennifer E Van Eyk; L T Thomas; Brian Tripet; R J Wiesner; Joyce R Pearlstone; Chuck S Farah; Fernando C Reinach; Robert S Hodges
Distinct regions of troponin I regulate Ca2+-dependent activation and Ca2+ sensitivity of the acto-S1-TM ATPase activity of the thin filament.
The Journal of biological chemistry 1997;272(16):10529-37.
1997: WD Kohn; Cyril M Kay; Robert S Hodges
Salt effects on protein stability: two-stranded alpha-helical coiled-coils containing inter- or intrahelical ion pairs.
Journal of molecular biology 1997;267(4):1039-52.
1997: Brian Tripet; Ronald D Vale; Robert S Hodges
Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides. Implications for motor activity.
The Journal of biological chemistry 1997;272(14):8946-56.
1997: A Patricia Campbell; Wah Y Wong; M Houston; Frank Schweizer; PJ Cachia; Randall T Irvin; Ole Hindsgaul; Robert S Hodges; Brian D Sykes
Interaction of the receptor binding domains of Pseudomonas aeruginosa pili strains PAK, PAO, KB7 and P1 to a cross-reactive antibody and receptor analog: implications for synthetic vaccine design.
Journal of molecular biology 1997;267(2):382-402.
1997: Brian Tripet; L Yu; Daisy L Bautista; Wah Y Wong; Randall T Irvin; Robert S Hodges
Engineering a de novo designed coiled-coil heterodimerization domain for the rapid detection, purification and characterization of recombinantly expressed peptides and proteins.
Protein engineering 1997;10(3):299.
1997: WD Kohn; Colin T Mant; Robert S Hodges
Alpha-helical protein assembly motifs.
The Journal of biological chemistry 1997;272(5):2583-6.
1997: C T Mant; Leslie H Kondejewski; PJ Cachia; O D Monera; Robert S Hodges
Analysis of synthetic peptides by high-performance liquid chromatography.
Methods in enzymology 1997;289():426-69.
1996: A Patricia Campbell; H Sheth; Robert S Hodges; Brian D Sykes
NMR solution structure of the receptor binding domain of Pseudomonas aeruginosa pilin strain P1. Identification of a beta-turn.
International journal of peptide and protein research 1996;48(6):539-52.
1996: Brian Tripet; L Yu; Daisy L Bautista; Wah Y Wong; Randall T Irvin; Robert S Hodges
Engineering a de novo-designed coiled-coil heterodimerization domain off the rapid detection, purification and characterization of recombinantly expressed peptides and proteins.
Protein engineering 1996;9(11):1029-42.
1996: Leslie H Kondejewski; S W Farmer; David S Wishart; Cyril M Kay; Robert E W Hancock; Robert S Hodges
Modulation of structure and antibacterial and hemolytic activity by ring size in cyclic gramicidin S analogs.
The Journal of biological chemistry 1996;271(41):25261-8.
1996: M E Houston; A Wallace; E Bianchi; A Pessi; Robert S Hodges
Use of a conformationally restricted secondary structural element to display peptide libraries: a two-stranded alpha-helical coiled-coil stabilized by lactam bridges.
Journal of molecular biology 1996;262(2):270-82.
1996: H Chao; M E Houston; S Grothe; Cyril M Kay; Maureen D O'Connor-McCourt; Randall T Irvin; Robert S Hodges
Kinetic study on the formation of a de novo designed heterodimeric coiled-coil: use of surface plasmon resonance to monitor the association and dissociation of polypeptide chains.
Biochemistry 1996;35(37):12175-85.
1996: M E Houston; A Patricia Campbell; Bruce Lix; Cyril M Kay; Brian D Sykes; Robert S Hodges
Lactam bridge stabilization of alpha-helices: the role of hydrophobicity in controlling dimeric versus monomeric alpha-helices.
Biochemistry 1996;35(31):10041-50.
1996: Leslie H Kondejewski; S W Farmer; David S Wishart; Robert E W Hancock; Robert S Hodges
Gramicidin S is active against both gram-positive and gram-negative bacteria.
International journal of peptide and protein research 1996;47(6):460-6.
1996: H Chao; Robert S Hodges; Cyril M Kay; S Y Gauthier; Peter L Davies
A natural variant of type I antifreeze protein with four ice-binding repeats is a particularly potent antifreeze.
Protein science : a publication of the Protein Society 1996;5(6):1150-6.
1996: KK Lee; L Yu; D L Macdonald; W Paranchych; Robert S Hodges; Randall T Irvin
Anti-adhesin antibodies that recognize a receptor-binding motif (adhesintope) inhibit pilus/fimbrial-mediated adherence of Pseudomonas aeruginosa and Candida albicans to asialo-GM1 receptors and human buccal epithelial cell surface receptors.
Canadian journal of microbiology 1996;42(5):479-86.
1996: O D Monera; F D Sönnichsen; L Hicks; Cyril M Kay; Robert S Hodges
The relative positions of alanine residues in the hydrophobic core control the formation of two-stranded or four-stranded alpha-helical coiled-coils.
Protein engineering 1996;9(4):353-63.
1996: L Yu; KK Lee; W Paranchych; Robert S Hodges; Randall T Irvin
Use of synthetic peptides to confirm that the Pseudomonas aeruginosa PAK pilus adhesin and the Candida albicans fimbrial adhesin possess a homologous receptor-binding domain.
Molecular microbiology 1996;19(5):1107-16.
1996: O D Monera; N E Zhou; P Lavigne; Cyril M Kay; Robert S Hodges
Formation of parallel and antiparallel coiled-coils controlled by the relative positions of alanine residues in the hydrophobic core.
The Journal of biological chemistry 1996;271(8):3995-4001.
1996: P Lavigne; F D Sönnichsen; Cyril M Kay; Robert S Hodges
Interhelical salt bridges, coiled-coil stability, and specificity of dimerization.
Science (New York, N.Y.) 1996;271(5252):1136-8.
1996: Robert S Hodges
Boehringer Mannheim award lecture 1995. La conference Boehringer Mannheim 1995. De novo design of alpha-helical proteins: basic research to medical applications.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1996;74(2):133-54.
1996: Colin T Mant; Robert S Hodges
Analysis of peptides by high-performance liquid chromatography.
Methods in enzymology 1996;271():3-50.
1995: A Patricia Campbell; Campbell McInnes; Robert S Hodges; Brian D Sykes
Comparison of NMR solution structures of the receptor binding domains of Pseudomonas aeruginosa pili strains PAO, KB7, and PAK: implications for receptor binding and synthetic vaccine design.
Biochemistry 1995;34(50):16255-68.
1995: P Lavigne; Leslie H Kondejewski; M E Houston; F D Sönnichsen; Bruce Lix; B D Skyes; Robert S Hodges; Cyril M Kay
Preferential heterodimeric parallel coiled-coil formation by synthetic Max and c-Myc leucine zippers: a description of putative electrostatic interactions responsible for the specificity of heterodimerization.
Journal of molecular biology 1995;254(3):505-20.
1995: WD Kohn; O D Monera; Cyril M Kay; Robert S Hodges
The effects of interhelical electrostatic repulsions between glutamic acid residues in controlling the dimerization and stability of two-stranded alpha-helical coiled-coils.
The Journal of biological chemistry 1995;270(43):25495-506.
1995: Wah Y Wong; A Patricia Campbell; Campbell McInnes; Brian D Sykes; W Paranchych; Randall T Irvin; Robert S Hodges
Structure-function analysis of the adherence-binding domain on the pilin of Pseudomonas aeruginosa strains PAK and KB7.
Biochemistry 1995;34(40):12963-72.
1995: O D Monera; T J Sereda; N E Zhou; Cyril M Kay; Robert S Hodges
Relationship of sidechain hydrophobicity and alpha-helical propensity on the stability of the single-stranded amphipathic alpha-helix.
Journal of peptide science : an official publication of the European Peptide Society 1995;1(5):319-29.
1995: M E Houston; C L Gannon; Cyril M Kay; Robert S Hodges
Lactam bridge stabilization of alpha-helical peptides: ring size, orientation and positional effects.
Journal of peptide science : an official publication of the European Peptide Society 1995;1(4):274-82.
1995: J Wang; Robert S Hodges; Brian D Sykes
Effect of trifluoroethanol on the solution structure and flexibility of desmopressin: a two-dimensional NMR study.
International journal of peptide and protein research 1995;45(5):471-81.
1995: David S Wishart; C G Bigam; Robert S Hodges; A Holm; Brian D Sykes
(1)H, (13)C and (15)N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects.
Journal of biomolecular NMR 1995;5(3):332.
1995: Jennifer E Van Eyk; R A Caday-Malcolm; L Yu; Randall T Irvin; Robert S Hodges
Anti-peptide monoclonal antibody imaging of a common binding domain involved in muscle regulation.
Protein science : a publication of the Protein Society 1995;4(4):781-90.
1995: T J Sereda; Colin T Mant; Robert S Hodges
Selectivity due to conformational differences between helical and non-helical peptides in reversed-phase chromatography.
Journal of chromatography. A 1995;695(2):205-21.
1995: Yuanpeng Zhang; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Interaction of a peptide model of a hydrophobic transmembrane alpha-helical segment of a membrane protein with phosphatidylethanolamine bilayers: differential scanning calorimetric and Fourier transform infrared spectroscopic studies.
Biophysical journal 1995;68(3):847-57.
1995: Yuanpeng Zhang; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Peptide models of helical hydrophobic transmembrane segments of membrane proteins. 2. Differential scanning calorimetric and FTIR spectroscopic studies of the interaction of Ac-K2-(LA)12-K2-amide with phosphatidylcholine bilayers.
Biochemistry 1995;34(7):2362-71.
1995: Yuanpeng Zhang; Ruthven N A H Lewis; G D Henry; Brian D Sykes; Robert S Hodges; Ronald N McElhaney
Peptide models of helical hydrophobic transmembrane segments of membrane proteins. 1. Studies of the conformation, intrabilayer orientation, and amide hydrogen exchangeability of Ac-K2-(LA)12-K2-amide.
Biochemistry 1995;34(7):2348-61.
1995: WD Kohn; Cyril M Kay; Robert S Hodges
Protein destabilization by electrostatic repulsions in the two-stranded alpha-helical coiled-coil/leucine zipper.
Protein science : a publication of the Protein Society 1995;4(2):237-50.
1995: H B Sheth; L M Glasier; N W Ellert; P Cachia; WD Kohn; KK Lee; W Paranchych; Robert S Hodges; Randall T Irvin
Development of an anti-adhesive vaccine for Pseudomonas aeruginosa targeting the C-terminal region of the pilin structural protein.
Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity 1995;1(3):141-8.
1995: David S Wishart; C G Bigam; A Holm; Robert S Hodges; Brian D Sykes
1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects.
Journal of biomolecular NMR 1995;5(1):67-81.
1995: KK Lee; Wah Y Wong; H B Sheth; Robert S Hodges; W Paranchych; Randall T Irvin
Use of synthetic peptides in characterization of microbial adhesins.
Methods in enzymology 1995;253():115-31.
1994: J Y Su; Robert S Hodges; Cyril M Kay
Effect of chain length on the formation and stability of synthetic alpha-helical coiled coils.
Biochemistry 1994;33(51):15501-10.
1994: L Yu; KK Lee; Robert S Hodges; W Paranchych; Randall T Irvin
Adherence of Pseudomonas aeruginosa and Candida albicans to glycosphingolipid (Asialo-GM1) receptors is achieved by a conserved receptor-binding domain present on their adhesins.
Infection and immunity 1994;62(12):5213-9.
1994: O D Monera; Cyril M Kay; Robert S Hodges
Protein denaturation with guanidine hydrochloride or urea provides a different estimate of stability depending on the contributions of electrostatic interactions.
Protein science : a publication of the Protein Society 1994;3(11):1984-91.
1994: N E Zhou; Cyril M Kay; Robert S Hodges
The net energetic contribution of interhelical electrostatic attractions to coiled-coil stability.
Protein engineering 1994;7(11):1365-72.
1994: Campbell McInnes; Cyril M Kay; Robert S Hodges; Brian D Sykes
Conformational differences between cis and trans proline isomers of a peptide antigen representing the receptor binding domain of Pseudomonas aeruginosa as studied by 1H-NMR.
Biopolymers 1994;34(9):1221-30.
1994: Robert S Hodges; B Y Zhu; N E Zhou; Colin T Mant
Reversed-phase liquid chromatography as a useful probe of hydrophobic interactions involved in protein folding and protein stability.
Journal of chromatography. A 1994;676(1):3-15.
1994: T J Sereda; Colin T Mant; F D Sönnichsen; Robert S Hodges
Reversed-phase chromatography of synthetic amphipathic alpha-helical peptides as a model for ligand/receptor interactions. Effect of changing hydrophobic environment on the relative hydrophilicity/hydrophobicity of amino acid side-chains.
Journal of chromatography. A 1994;676(1):139-53.
1994: L Yu; KK Lee; H B Sheth; P Lane-Bell; G Srivastava; Ole Hindsgaul; W Paranchych; Robert S Hodges; Randall T Irvin
Fimbria-mediated adherence of Candida albicans to glycosphingolipid receptors on human buccal epithelial cells.
Infection and immunity 1994;62(7):2843-8.
1994: L Yu; KK Lee; K Ens; P C Doig; M R Carpenter; W Staddon; Robert S Hodges; W Paranchych; Randall T Irvin
Partial characterization of a Candida albicans fimbrial adhesin.
Infection and immunity 1994;62(7):2834-42.
1994: Gary Shaw; Robert S Hodges; Cyril M Kay; Brian D Sykes
Relative stabilities of synthetic peptide homo- and heterodimeric troponin-C domains.
Protein science : a publication of the Protein Society 1994;3(7):1010-9.
1994: N E Zhou; Cyril M Kay; Robert S Hodges
The role of interhelical ionic interactions in controlling protein folding and stability. De novo designed synthetic two-stranded alpha-helical coiled-coils.
Journal of molecular biology 1994;237(4):500-12.
1994: O D Monera; Cyril M Kay; Robert S Hodges
Electrostatic interactions control the parallel and antiparallel orientation of alpha-helical chains in two-stranded alpha-helical coiled-coils.
Biochemistry 1994;33(13):3862-71.
1994: J M Parker; Robert S Hodges
HomologyPlot: searching for homology to a family of proteins using a database of unique conserved patterns.
Journal of computer-aided molecular design 1994;8(2):193-210.
1994: H B Sheth; KK Lee; Wah Y Wong; G Srivastava; Ole Hindsgaul; Robert S Hodges; W Paranchych; Randall T Irvin
The pili of Pseudomonas aeruginosa strains PAK and PAO bind specifically to the carbohydrate sequence beta GalNAc(1-4)beta Gal found in glycosphingolipids asialo-GM1 and asialo-GM2.
Molecular microbiology 1994;11(4):715-23.
1994: KK Lee; H B Sheth; Wah Y Wong; RK Sherburne; W Paranchych; Robert S Hodges; Clifford A Lingwood; H Krivan; Randall T Irvin
The binding of Pseudomonas aeruginosa pili to glycosphingolipids is a tip-associated event involving the C-terminal region of the structural pilin subunit.
Molecular microbiology 1994;11(4):705-13.
1994: S M Ngai; F D Sönnichsen; Robert S Hodges
Photochemical cross-linking between native rabbit skeletal troponin C and benzoylbenzoyl-troponin I inhibitory peptide, residues 104-115.
The Journal of biological chemistry 1994;269(3):2165-72.
1993: Campbell McInnes; F D Sönnichsen; Cyril M Kay; Robert S Hodges; Brian D Sykes
NMR solution structure and flexibility of a peptide antigen representing the receptor binding domain of Pseudomonas aeruginosa.
Biochemistry 1993;32(49):13432-40.
1993: O D Monera; N E Zhou; Cyril M Kay; Robert S Hodges
Comparison of antiparallel and parallel two-stranded alpha-helical coiled-coils. Design, synthesis, and characterization.
The Journal of biological chemistry 1993;268(26):19218-27.
1993: T J Sereda; Colin T Mant; A M Quinn; Robert S Hodges
Effect of the alpha-amino group on peptide retention behaviour in reversed-phase chromatography. Determination of the pK(a) values of the alpha-amino group of 19 different N-terminal amino acid residues.
Journal of chromatography 1993;646(1):17-30.
1993: N E Zhou; Cyril M Kay; Brian D Sykes; Robert S Hodges
A single-stranded amphipathic alpha-helix in aqueous solution: design, structural characterization, and its application for determining alpha-helical propensities of amino acids.
Biochemistry 1993;32(24):6190-7.
1993: Jennifer E Van Eyk; J D Strauss; Robert S Hodges; J Caspar Rüegg
A synthetic peptide mimics troponin I function in the calcium-dependent regulation of muscle contraction.
FEBS letters 1993;323(3):223-8.
1993: N E Zhou; Cyril M Kay; Robert S Hodges
Disulfide bond contribution to protein stability: positional effects of substitution in the hydrophobic core of the two-stranded alpha-helical coiled-coil.
Biochemistry 1993;32(12):3178-87.
1993: B Y Zhu; N E Zhou; Cyril M Kay; Robert S Hodges
Packing and hydrophobicity effects on protein folding and stability: effects of beta-branched amino acids, valine and isoleucine, on the formation and stability of two-stranded alpha-helical coiled coils/leucine zippers.
Protein science : a publication of the Protein Society 1993;2(3):383-94.
1992: Yuanpeng Zhang; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
Interaction of a peptide model of a hydrophobic transmembrane alpha-helical segment of a membrane protein with phosphatidylcholine bilayers: differential scanning calorimetric and FTIR spectroscopic studies.
Biochemistry 1992;31(46):11579-88.
1992: Yuanpeng Zhang; Ruthven N A H Lewis; Robert S Hodges; Ronald N McElhaney
FTIR spectroscopic studies of the conformation and amide hydrogen exchange of a peptide model of the hydrophobic transmembrane alpha-helices of membrane proteins.
Biochemistry 1992;31(46):11572-8.
1992: A Patricia Campbell; Jennifer E Van Eyk; Robert S Hodges; Brian D Sykes
Interaction of troponin I and troponin C: use of the two-dimensional transferred nuclear Overhauser effect to determine the structure of a Gly-110 inhibitory troponin I peptide analog when bound to cardiac troponin C.
Biochimica et biophysica acta 1992;1160(1):35-54.
1992: Gary Shaw; Robert S Hodges; Brian D Sykes
Determination of the solution structure of a synthetic two-site calcium-binding homodimeric protein domain by NMR spectroscopy.
Biochemistry 1992;31(40):9572-80.
1992: Wah Y Wong; Randall T Irvin; W Paranchych; Robert S Hodges
Antigen-antibody interactions: elucidation of the epitope and strain-specificity of a monoclonal antibody directed against the pilin protein adherence binding domain of Pseudomonas aeruginosa strain K.
Protein science : a publication of the Protein Society 1992;1(10):1308-18.
1992: F D Sönnichsen; Jennifer E Van Eyk; Robert S Hodges; Brian D Sykes
Effect of trifluoroethanol on protein secondary structure: an NMR and CD study using a synthetic actin peptide.
Biochemistry 1992;31(37):8790-8.
1992: B Y Zhu; N E Zhou; P D Semchuk; Cyril M Kay; Robert S Hodges
Design, synthesis and structural characterization of model heterodimeric coiled-coil proteins.
International journal of peptide and protein research 1992;40(3-4):171-9.
1992: S M Ngai; Robert S Hodges
Biologically important interactions between synthetic peptides of the N-terminal region of troponin I and troponin C.
The Journal of biological chemistry 1992;267(22):15715-20.
1992: O D Monera; Gary Shaw; B Y Zhu; Brian D Sykes; Cyril M Kay; Robert S Hodges
Role of interchain alpha-helical hydrophobic interactions in Ca2+ affinity, formation, and stability of a two-site domain in troponin C.
Protein science : a publication of the Protein Society 1992;1(7):945-55.
1992: N E Zhou; Cyril M Kay; Robert S Hodges
Synthetic model proteins: the relative contribution of leucine residues at the nonequivalent positions of the 3-4 hydrophobic repeat to the stability of the two-stranded alpha-helical coiled-coil.
Biochemistry 1992;31(25):5739-46.
1992: N E Zhou; B Y Zhu; Cyril M Kay; Robert S Hodges
The two-stranded alpha-helical coiled-coil is an ideal model for studying protein stability and subunit interactions.
Biopolymers 1992;32(4):419-26.
1992: Gary Shaw; Robert S Hodges; Brian D Sykes
Stoichiometry of calcium binding to a synthetic heterodimeric troponin-C domain.
Biopolymers 1992;32(4):391-7.
1992: N E Zhou; Cyril M Kay; Robert S Hodges
Synthetic model proteins. Positional effects of interchain hydrophobic interactions on stability of two-stranded alpha-helical coiled-coils.
The Journal of biological chemistry 1992;267(4):2664-70.
1991: Jennifer E Van Eyk; Robert S Hodges
A synthetic peptide of the N-terminus of actin interacts with myosin.
Biochemistry 1991;30(50):11676-82.
1991: J M Parker; Robert S Hodges
Prediction of surface and interior regions in proteins--Part II: Predicting secondary structure in regions bound by surface exposed regions.
Peptide research 1991;4(6):355-63.
1991: J M Parker; Robert S Hodges
Prediction of surface and interior regions in proteins--Part I: Linear tripeptide sequences identify structural boundaries in proteins.
Peptide research 1991;4(6):347-54.
1991: Jennifer E Van Eyk; Cyril M Kay; Robert S Hodges
A comparative study of the interactions of synthetic peptides of the skeletal and cardiac troponin I inhibitory region with skeletal and cardiac troponin C.
Biochemistry 1991;30(41):9974-81.
1991: Gary Shaw; Robert S Hodges; Brian D Sykes
Probing the relationship between alpha-helix formation and calcium affinity in troponin C: 1H NMR studies of calcium binding to synthetic and variant site III helix-loop-helix peptides.
Biochemistry 1991;30(34):8339-47.
1991: Robert S Hodges; T W Burke; Colin T Mant
Multi-column preparative reversed-phase sample displacement chromatography of peptides.
Journal of chromatography 1991;548(1-2):267-80.
1991: B Y Zhu; Colin T Mant; Robert S Hodges
Hydrophilic-interaction chromatography of peptides on hydrophilic and strong cation-exchange columns.
Journal of chromatography 1991;548(1-2):13-24.
1991: N E Zhou; Colin T Mant; J J Kirkland; Robert S Hodges
Comparison of silica-based cyanopropyl and octyl reversed-phase packings for the separation of peptides and proteins.
Journal of chromatography 1991;548(1-2):179-93.
1990: KK Lee; W Paranchych; Robert S Hodges
Cross-reactive and strain-specific antipeptide antibodies to Pseudomonas aeruginosa PAK and PAO pili.
Infection and immunity 1990;58(9):2727-32.
1990: Gary Shaw; Robert S Hodges; Brian D Sykes
Calcium-induced peptide association to form an intact protein domain: 1H NMR structural evidence.
Science (New York, N.Y.) 1990;249(4966):280-3.
1990: Robert S Hodges; N E Zhou; Cyril M Kay; P D Semchuk
Synthetic model proteins: contribution of hydrophobic residues and disulfide bonds to protein stability.
Peptide research 1990;3(3):123-37.
1990: N E Zhou; Colin T Mant; Robert S Hodges
Effect of preferred binding domains on peptide retention behavior in reversed-phase chromatography: amphipathic alpha-helices.
Peptide research 1990;3(1):8-20.
1990: P Doig; P A Sastry; Robert S Hodges; KK Lee; W Paranchych; Randall T Irvin
Inhibition of pilus-mediated adhesion of Pseudomonas aeruginosa to human buccal epithelial cells by monoclonal antibodies directed against pili.
Infection and immunity 1990;58(1):124-30.
1989: Colin T Mant; T W Burke; N E Zhou; J M Parker; Robert S Hodges
Reversed-phase chromatographic method development for peptide separations using the computer simulation program ProDigest-LC.
Journal of chromatography 1989;485():365-82.
1989: Randall T Irvin; P Doig; KK Lee; P A Sastry; W Paranchych; T Todd; Robert S Hodges
Characterization of the Pseudomonas aeruginosa pilus adhesin: confirmation that the pilin structural protein subunit contains a human epithelial cell-binding domain.
Infection and immunity 1989;57(12):3720-6.
1989: KK Lee; P Doig; Randall T Irvin; W Paranchych; Robert S Hodges
Mapping the surface regions of Pseudomonas aeruginosa PAK pilin: the importance of the C-terminal region for adherence to human buccal epithelial cells.
Molecular microbiology 1989;3(11):1493-9.
1989: B J Marsden; Robert S Hodges; Brian D Sykes
A 1H NMR determination of the solution conformation of a synthetic peptide analogue of calcium-binding site III of rabbit skeletal troponin C.
Biochemistry 1989;28(22):8839-47.
1989: T W Burke; Colin T Mant; J A Black; Robert S Hodges
Strong cation-exchange high-performance liquid chromatography of peptides. Effect of non-specific hydrophobic interactions and linearization of peptide retention behaviour.
Journal of chromatography 1989;476():377-89.
1989: Colin T Mant; N E Zhou; Robert S Hodges
Correlation of protein retention times in reversed-phase chromatography with polypeptide chain length and hydrophobicity.
Journal of chromatography 1989;476():363-75.
1989: J Caspar Rüegg; C Zeugner; Jennifer E Van Eyk; Cyril M Kay; Robert S Hodges
Inhibition of TnI-TnC interaction and contraction of skinned muscle fibres by the synthetic peptide TnI [104-115].
Pflügers Archiv : European journal of physiology 1989;414(4):430-6.
1989: KK Lee; P A Sastry; W Paranchych; Robert S Hodges
Immunological studies of the disulfide bridge region of Pseudomonas aeruginosa PAK and PAO pilins, using anti-PAK pilus and antipeptide antibodies.
Infection and immunity 1989;57(2):520-6.
1988: Colin T Mant; T W Burke; J A Black; Robert S Hodges
Effect of peptide chain length on peptide retention behaviour in reversed-phase chromatography.
Journal of chromatography 1988;458():193-205.
1988: Robert S Hodges; J M Parker; Colin T Mant; R R Sharma
Computer simulation of high-performance liquid chromatographic separations of peptide and protein digests for development of size-exclusion, ion-exchange and reversed-phase chromatographic methods.
Journal of chromatography 1988;458():147-67.
1988: Robert S Hodges; P D Semchuk; A K Taneja; Cyril M Kay; J M Parker; Colin T Mant
Protein design using model synthetic peptides.
Peptide research 1988;1(1):19-30.
1988: N C Strynadka; Mark Redmond; J M Parker; D G Scraba; Robert S Hodges
Use of synthetic peptides to map the antigenic determinants of glycoprotein D of herpes simplex virus.
Journal of virology 1988;62(9):3474-83.
1988: Robert S Hodges; R J Heaton; J M Parker; Laurie L Molday; Robert S Molday
Antigen-antibody interaction. Synthetic peptides define linear antigenic determinants recognized by monoclonal antibodies directed to the cytoplasmic carboxyl terminus of rhodopsin.
The Journal of biological chemistry 1988;263(24):11768-75.
1988: R H Ingraham; Robert S Hodges
Effects of Ca2+ and subunit interactions on surface accessibility of cysteine residues in cardiac troponin.
Biochemistry 1988;27(16):5891-8.
1988: Robert S Hodges; T W Burke; Colin T Mant
Preparative purification of peptides by reversed-phase chromatography. Sample displacement mode versus gradient elution mode.
Journal of chromatography 1988;444():349-62.
1988: M H Watson; A K Taneja; Robert S Hodges; Alan S Mak
Phosphorylation of alpha alpha- and beta beta-tropomyosin and synthetic peptide analogues.
Biochemistry 1988;27(12):4506-12.
1988: P Doig; T Todd; P A Sastry; KK Lee; Robert S Hodges; W Paranchych; Randall T Irvin
Role of pili in adhesion of Pseudomonas aeruginosa to human respiratory epithelial cells.
Infection and immunity 1988;56(6):1641-6.
1988: B J Marsden; Robert S Hodges; Brian D Sykes
1H-NMR studies of synthetic peptide analogues of calcium-binding site III of rabbit skeletal troponin C: effect on the lanthanum affinity of the interchange of aspartic acid and asparagine residues at the metal ion coordinating positions.
Biochemistry 1988;27(11):4198-206.
1988: Jennifer E Van Eyk; Robert S Hodges
The biological importance of each amino acid residue of the troponin I inhibitory sequence 104-115 in the interaction with troponin C and tropomyosin-actin.
The Journal of biological chemistry 1988;263(4):1726-32.
1987: Jennifer E Van Eyk; Robert S Hodges
Calmodulin and troponin C: affinity chromatographic study of divalent cation requirements for troponin I inhibitory peptide (residues 104-115), mastoparan and fluphenazine binding.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1987;65(11):982-8.
1987: Colin T Mant; J M Parker; Robert S Hodges
Size-exclusion high-performance liquid chromatography of peptides. Requirement for peptide standards to monitor column performance and non-ideal behaviour.
Journal of chromatography 1987;397():99-112.
1986: E A Worobec; L S Frost; P Pieroni; Glen D Armstrong; Robert S Hodges; J M Parker; B B Finlay; W Paranchych
Location of the antigenic determinants of conjugative F-like pili.
Journal of bacteriology 1986;167(2):660-5.
1985: B B Finlay; L S Frost; W Paranchych; J M Parker; Robert S Hodges
Major antigenic determinants of F and ColB2 pili.
Journal of bacteriology 1985;163(1):331-5.
1985: E A Worobec; W Paranchych; J M Parker; A K Taneja; Robert S Hodges
Antigen-antibody interaction. The immunodominant region of EDP208 pili.
The Journal of biological chemistry 1985;260(2):938-43.
1983: E A Worobec; A K Taneja; Robert S Hodges; W Paranchych
Localization of the major antigenic determinant of EDP208 pili at the N-terminus of the pilus protein.
Journal of bacteriology 1983;153(2):955-61.