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William Hodnick

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Chemicals & Drugs

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Oxidation-Reduction

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CHO Cells

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Bayard R Huck; Luis Llamas; Michael J Robarge; Tom Dent; Jianping Song; William F Hodnick; Chris Crumrine; Alain Stricker-Krongrad; John Harrington; Kurt R Brunden; Youssef L Bennani
The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist.
Bayard R Huck; Luis Llamas; Michael J Robarge; Tom Dent; Jianping Song; William F Hodnick; Chris Crumrine; Alain Stricker-Krongrad; John Harrington; Kurt R Brunden; Youssef L Bennani
The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists.
James T Anderson; Anthony E Ting; Sherry Boozer; Kurt R Brunden; Chris Crumrine; Joel Danzig; Tom Dent; Laurel Faga; John J Harrington; William F Hodnick; Steven M Murphy; Gary Pawlowski; Robert Perry; Amy Raber; Stephen E Rundlett; Alain Stricker-Krongrad; Jianmin Wang; Youssef L Bennani
Identification of novel and improved antimitotic agents derived from noscapine.

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All Publications

2006: Bayard R Huck; Luis Llamas; Michael J Robarge; Tom Dent; Jianping Song; William F Hodnick; Chris Crumrine; Alain Stricker-Krongrad; John Harrington; Kurt R Brunden; Youssef L Bennani
The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist.
Bioorganic & medicinal chemistry letters 2006;16(15):4130-4.
2006: Bayard R Huck; Luis Llamas; Michael J Robarge; Tom Dent; Jianping Song; William F Hodnick; Chris Crumrine; Alain Stricker-Krongrad; John Harrington; Kurt R Brunden; Youssef L Bennani
The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists.
Bioorganic & medicinal chemistry letters 2006;16(11):2891-4.
2005: James T Anderson; Anthony E Ting; Sherry Boozer; Kurt R Brunden; Chris Crumrine; Joel Danzig; Tom Dent; Laurel Faga; John J Harrington; William F Hodnick; Steven M Murphy; Gary Pawlowski; Robert Perry; Amy Raber; Stephen E Rundlett; Alain Stricker-Krongrad; Jianmin Wang; Youssef L Bennani
Identification of novel and improved antimitotic agents derived from noscapine.
Journal of medicinal chemistry 2005;48(23):7096-8.
2005: Helen A Seow; Michael F Belcourt; Philip G Penketh; William F Hodnick; Maria Tomasz; Sara Rockwell; Alan C Sartorelli
Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells.
Molecular pharmacology 2005;67(2):417-23.
2001: Raymond P Baumann; William F Hodnick; Helen A Seow; Michael F Belcourt; S Rockwell; David H Sherman; Alan C Sartorelli
Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.
Cancer research 2001;61(21):7770-6.
2001: Philip G Penketh; William F Hodnick; Michael F Belcourt; Krishnamurthy Shyam; David H Sherman; Alan C Sartorelli
Inhibition of DNA cross-linking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone.
The Journal of biological chemistry 2001;276(37):34445-52.
1999: Michael F Belcourt; Philip G Penketh; William F Hodnick; D A Johnson; David H Sherman; S Rockwell; Alan C Sartorelli
Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(18):10489-94.
1998: Michael F Belcourt; William F Hodnick; S Rockwell; Alan C Sartorelli
The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells.
The Journal of biological chemistry 1998;273(15):8875-81.
1998: Michael F Belcourt; William F Hodnick; S Rockwell; Alan C Sartorelli
Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase.
Advances in enzyme regulation 1998;38():111-33.
1997: William F Hodnick; Alan C Sartorelli
Measurement of dicumarol-sensitive NADPH: (menadione-cytochrome c) oxidoreductase activity results in an artifactual assay of DT-diaphorase in cell sonicates.
Analytical biochemistry 1997;252(1):165-8.
1997: JA Sokoloski; William F Hodnick; Susan T Mayne; C Cinquina; CS Kim; Alan C Sartorelli
Induction of the differentiation of HL-60 promyelocytic leukemia cells by vitamin E and other antioxidants in combination with low levels of vitamin D3: possible relationship to NF-kappaB.
Leukemia 1997;11(9):1546-53.
1996: Michael F Belcourt; William F Hodnick; S Rockwell; Alan C Sartorelli
Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase.
Biochemical pharmacology 1996;51(12):1669-78.
1996: Michael F Belcourt; William F Hodnick; S Rockwell; Alan C Sartorelli
Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):456-60.
1995: Alan C Sartorelli; Michael F Belcourt; William F Hodnick; S R Keyes; Chris A Pritsos; S Rockwell
Preferential kill of hypoxic EMT6 mammary tumor cells by the bioreductive alkylating agent porfiromycin.
Advances in enzyme regulation 1995;35():117-30.
1994: William F Hodnick; Alan C Sartorelli
The pH-dependent reduction of Adriamycin catalysed by NADH:cytochrome b5 reductase.
Cancer letters 1994;84(2):149-54.
1994: William F Hodnick; D L Duval; Ronald S Pardini
Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids.
Biochemical pharmacology 1994;47(3):573-80.
1994: Alan C Sartorelli; William F Hodnick; Michael F Belcourt; Maria Tomasz; B Haffty; J J Fischer; S Rockwell
Mitomycin C: a prototype bioreductive agent.
Oncology research 1994;6(10-11):501-8.
1993: William F Hodnick; Alan C Sartorelli
Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.
Cancer research 1993;53(20):4907-12.
1988: William F Hodnick; E B Milosavljević; J H Nelson; Ronald S Pardini
Electrochemistry of flavonoids. Relationships between redox potentials, inhibition of mitochondrial respiration, and production of oxygen radicals by flavonoids.
Biochemical pharmacology 1988;37(13):2607-11.
1988: William F Hodnick; B Kalyanaraman; Chris A Pritsos; Ronald S Pardini
The production of hydroxyl and semiquinone free radicals during the autoxidation of redox active flavonoids.
Basic life sciences 1988;49():149-52.
1987: William F Hodnick; C W Bohmont; C Capps; Ronald S Pardini
Inhibition of the mitochondrial NADH-oxidase (NADH-coenzyme Q oxido-reductase) enzyme system by flavonoids: a structure-activity study.
Biochemical pharmacology 1987;36(17):2873-4.
1986: William F Hodnick; F S Kung; W J Roettger; C W Bohmont; Ronald S Pardini
Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure-activity study.
Biochemical pharmacology 1986;35(14):2345-57.
1986: William F Hodnick; W J Roettger; F S Kung; C W Bohmont; Ronald S Pardini
Inhibition of mitochondrial respiration and production of superoxide and hydrogen peroxide by flavonoids: a structure activity study.
Progress in clinical and biological research 1986;213():249-52.