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Holger Hoehn

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Kornelia Neveling; Daniela Endt; Holger Hoehn; Detlev Schindler
Genotype-phenotype correlations in Fanconi anemia.
Ralph Melcher; Waltraud Zopf; Elena Hartmann; Andreas Rosenwald; Holger Hoehn; Michael Schmid; Theodor Kudlich; Michael Scheurlen; Hardi Luehrs
Spectral karyotyping and SNP microarray analysis define uniparental disomy (UPD) as a novel mutational mechanism in MSI- and CSI-colorectal cancers.
Holger Hoehn; Kornelia Neveling; Daniela Endt; Ralph Melcher; Detlev Schindler
Neoplasia, ageing, and genetic instability due to defective caretaker genes.

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All Publications

2009: Kornelia Neveling; Daniela Endt; Holger Hoehn; Detlev Schindler
Genotype-phenotype correlations in Fanconi anemia.
Mutation research 2009;668(1-2):73-91.
2008: Ralph Melcher; Waltraud Zopf; Elena Hartmann; Andreas Rosenwald; Holger Hoehn; Michael Schmid; Theodor Kudlich; Michael Scheurlen; Hardi Luehrs
Spectral karyotyping and SNP microarray analysis define uniparental disomy (UPD) as a novel mutational mechanism in MSI- and CSI-colorectal cancers.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2008;30(6):507.
2008: Holger Hoehn; Kornelia Neveling; Daniela Endt; Ralph Melcher; Detlev Schindler
Neoplasia, ageing, and genetic instability due to defective caretaker genes.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2008;30(5):461-2.
2007: Kornelia Neveling; A Bechtold; Holger Hoehn
Genetic instability syndromes with progeroid features.
Zeitschrift für Gerontologie und Geriatrie 2007;40(5):339-48.
2007: Reinhard Kalb; Kornelia Neveling; Holger Hoehn; Hildegard Schneider; Yvonne Linka; Sat Dev Batish; Curtis Hunt; Marianne Berwick; Elsa Callen; Jordi Surralles; José A Casado; Juan A. Bueren; Angeles Dasi; Jean Soulier; Eliane Gluckman; C Michel Zwaan; Rosalina Spaendonk; Gerard Pals; Johan P de Winter; Hans Joenje; Markus Grompe; Arleen D Auerbach; Helmut Hanenberg; Detlev Schindler
Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype.
American journal of human genetics 2007;80(5):895-910.
2007: Kornelia Neveling; Reinhard Kalb; Andrea R Florl; Sabine Herterich; Richard Friedl; Holger Hoehn; Christiane Hader; F H Hartmann; Indrajit Nanda; Claus Steinlein; Michael Schmid; H Tonnies; C D Hurst; M A Knowles; Helmut Hanenberg; W A Schulz; Detlev Schindler
Disruption of the FA/BRCA pathway in bladder cancer.
Cytogenetic and genome research 2007;118(2-4):166-76.
2007: Bernd Gruhn; Joerg Seidel; Felix Zintl; Raymonda Varon; Holger Tönnies; Heidemarie Neitzel; Astrid Bechtold; Holger Hoehn; Detlev Schindler
Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure.
Orphanet journal of rare diseases 2007;2():5.
2006: Susann Bürger; Detlev Schindler; Martin Fehn; Bettina Mühl; Hartmut Mahrhofer; Michael Flentje; Holger Hoehn; Eva Seemanová; Cholpon S Djuzenova
Radiation-induced DNA damage and repair in peripheral blood mononuclear cells from Nijmegen breakage syndrome patients and carriers assessed by the Comet assay.
Environmental and molecular mutagenesis 2006;47(4):260-70.
2006: Tilman Heinrich; Carolin Prowald; Richard Friedl; Benni Gottwald; Reinhard Kalb; Kornelia Neveling; Sabine Herterich; Holger Hoehn; Detlev Schindler
Exclusion/confirmation of ataxia-telangiectasia via cell-cycle testing.
European journal of pediatrics 2006;165(4):250-7.
2006: Astrid Bechtold; Richard Friedl; Reinhard Kalb; Benni Gottwald; Kornelia Neveling; Ioannis Gavvovidis; Sabine Herterich; Detlev Schindler; Holger Hoehn
Prenatal exclusion/confirmation of Fanconi anemia via flow cytometry: a pilot study.
Fetal diagnosis and therapy 2006;21(1):118-24.
2004: Anke Hartmann; Uta B Hofmann; Holger Hoehn; Eva B Broecker; Henning Hamm
Postnatal confirmation of prenatally diagnosed trisomy 20 mosaicism in a patient with linear and whorled nevoid hypermelanosis.
Pediatric dermatology 2004;21(6):636-41.
2004: Reinhard Kalb; Michael Duerr; Matthias Wagner; Sabine Herterich; Michaela Gross; Martin Digweed; Hans Joenje; Holger Hoehn; Detlev Schindler
Lack of sensitivity of primary Fanconi's anemia fibroblasts to UV and ionizing radiation.
Radiation research 2004;161(3):318-25.
2003: Tanja Reuter; Annette L Medhurst; Quinten Waisfisz; Yu Zhi; Sabine Herterich; Holger Hoehn; Hans J Gross; Hans Joenje; Maureen Hoatlin; Christopher G Mathew; Pia A J Huber
Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
Experimental cell research 2003;289(2):211-21.
2002: M Gross; Helmut Hanenberg; Stephan Lobitz; Richard Friedl; Sabine Herterich; R Dietrich; Bernd Gruhn; Detlev Schindler; Holger Hoehn
Reverse mosaicism in Fanconi anemia: natural gene therapy via molecular self-correction.
Cytogenetic and genome research 2002;98(2-3):126-35.
2001: Cholpon S Djuzenova; A Rothfuss; Ulrich Oppitz; G Spelt; Detlev Schindler; Holger Hoehn; Michael Flentje
Response to X-irradiation of Fanconi anemia homozygous and heterozygous cells assessed by the single-cell gel electrophoresis (comet) assay.
Laboratory investigation; a journal of technical methods and pathology 2001;81(2):185-92.
2000: Tanja Reuter; Sabine Herterich; O Bernhard; Holger Hoehn; Hans J Gross
Strong FANCA/FANCG but weak FANCA/FANCC interaction in the yeast 2-hybrid system.
Blood 2000;95(2):719-20.
2000: Ralph Melcher; R von Golitschek; Claus Steinlein; Detlev Schindler; Heidemarie Neitzel; K Kainer; Michael Schmid; Holger Hoehn
Spectral karyotyping of Werner syndrome fibroblast cultures.
Cytogenetics and cell genetics 2000;91(1-4):180-5.
1999: Ulrich Oppitz; U Bernthaler; Detlev Schindler; Alexandra Sobeck; Holger Hoehn; Matthias Platzer; A Rosenthal; Michael Flentje
Sequence analysis of the ATM gene in 20 patients with RTOG grade 3 or 4 acute and/or late tissue radiation side effects.
International journal of radiation oncology, biology, physics 1999;44(5):981-8.
1999: Cholpon S Djuzenova; Detlev Schindler; Helga Stopper; Holger Hoehn; Michael Flentje; Ulrich Oppitz
Identification of ataxia telangiectasia heterozygotes, a cancer-prone population, using the single-cell gel electrophoresis (Comet) assay.
Laboratory investigation; a journal of technical methods and pathology 1999;79(6):699-705.
1998: Johan P de Winter; Quinten Waisfisz; Martin A Rooimans; Carola G M van Berkel; Lucine Bosnoyan-Collins; Noa Alon; Madeleine Carreau; O Bender; Ilja Demuth; Detlev Schindler; Jan C Pronk; Fré Arwert; Holger Hoehn; Martin Digweed; Manuel Buchwald; Hans Joenje
The Fanconi anaemia group G gene FANCG is identical with XRCC9.
Nature genetics 1998;20(3):281-3.
1998: Hans Joenje; Fré Arwert; Mei Lan Kwee; K Madan; Holger Hoehn
Confounding factors in the diagnosis of Fanconi anaemia.
American journal of medical genetics 1998;79(5):403-5.
1998: Kathrin Saar; Detlev Schindler; Rolf-Dieter Wegner; A Reis; Thomas F Wienker; Holger Hoehn; Hans Joenje; Karl Sperling; Martin Digweed
Localisation of a Fanconi anaemia gene to chromosome 9p.
European journal of human genetics : EJHG 1998;6(5):501-8.
1998: A Zellner; Jürgen Meixensberger; Wolfgang Roggendorf; M Janka; Holger Hoehn; Klaus Roosen
DNA ploidy and cell-cycle analysis in intracranial meningiomas and hemangiopericytomas: a study with high-resolution DNA flow cytometry.
International journal of cancer. Journal international du cancer 1998;79(2):116-20.
1997: W Liebetrau; Thomas M. Ruenger; BE Mehling; Martin Poot; Holger Hoehn
Mutagenic activity of ambient oxygen and mitomycin C in Fanconi's anaemia cells.
Mutagenesis 1997;12(2):69-77.
1997: W Liebetrau; A Budde; A Savoia; Friedrich Grummt; Holger Hoehn
p53 activates Fanconi anemia group C gene expression.
Human molecular genetics 1997;6(2):277-83.
1997: W Liebetrau; T M Rünge; A Baumer; C Henning; O Gross; Detlev Schindler; Martin Poot; Holger Hoehn
Exploring the role of oxygen in Fanconi's anemia.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1997;143():353-67.
1996: A Baumer; U Bernthaler; W Wolz; Holger Hoehn; Detlev Schindler
New mutations in the ataxia telangiectasia gene.
Human genetics 1996;98(2):246-9.
1996: M Poot; O Gross; Bernd Epe; M Pflaum; Holger Hoehn
Cell cycle defect in connection with oxygen and iron sensitivity in Fanconi anemia lymphoblastoid cells.
Experimental cell research 1996;222(2):262-8.
1995: M Poot; Karl-Heinz Hiller; S Heimpel; A Schuster; J Köhler; Holger Hoehn
Heterogeneity of bromodeoxyuridine sensitivity of cultured cells from melanoma metastases.
Cytometry 1995;21(1):62-7.
1995: W Liebetrau; M Bühner; Holger Hoehn
Prototype sequence clues within the Fanconi anaemia group C gene.
Journal of medical genetics 1995;32(8):669-70.
1995: M Poot; Karl-Heinz Hiller; S Heimpel; Holger Hoehn
Distinct patterns of cell cycle disturbance elicited by compounds interfering with DNA topoisomerase I and II activity.
Experimental cell research 1995;218(1):326-30.
1995: H Seyschab; R Friedl; Y Sun; Detlev Schindler; Holger Hoehn; S Hentze; T Schroeder-Kurth
Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia.
Blood 1995;85(8):2233-7.
1994: H Seyschab; G Bretzel; R Friedl; Detlev Schindler; Y Sun; Holger Hoehn
Modulation of the spontaneous G2 phase blockage in Fanconi anemia cells by caffeine: differences from cells arrested by X-irradiation.
Mutation research 1994;308(2):149-57.
1994: M Poot; Holger Hoehn; M Kubbies; A Grossmann; Y Chen; Peter S Rabinovitch
Cell-cycle analysis using continuous bromodeoxyuridine labeling and Hoechst 33358-ethidium bromide bivariate flow cytometry.
Methods in cell biology 1994;41():327-40.
1993: H Seyschab; Y Sun; R Friedl; Detlev Schindler; Holger Hoehn
G2 phase cell cycle disturbance as a manifestation of genetic cell damage.
Human genetics 1993;92(1):61-8.
1993: M Poot; Holger Hoehn
DNA topoisomerases and the DNA lesion in human genetic instability syndromes.
Toxicology letters 1993;67(1-3):297-308.
1993: E M Weller; M Poot; Holger Hoehn
Induction of replicative senescence by 5-azacytidine: fundamental cell kinetic differences between human diploid fibroblasts and NIH-3T3 cells.
Cell proliferation 1993;26(1):45-54.
1992: M Poot; Bernd Epe; Holger Hoehn
Cell cycle effects of the DNA topoisomerase inhibitors camptothecin and m-AMSA in lymphoblastoid cell lines from patients with Fanconi anemia.
Mutation research 1992;270(2):185-9.
1992: M Poot; Holger Hoehn; Thomas M. Ruenger; G M Martin
Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines.
Experimental cell research 1992;202(2):267-73.
1991: H Seyschab; Holger Hoehn; Peter S Rabinovitch; U Chen
Differential activity of recombinant lymphokines on mouse B cell proliferation and cell cycle progression are revealed by 5-bromo-2'-deoxyuridine/Hoechst 33258 dye flow cytometry.
European journal of immunology 1991;21(9):2153-60.
1991: M Poot; A Schuster; Holger Hoehn
Cytostatic synergism between bromodeoxyuridine, bleomycin, cisplatin and chlorambucil demonstrated by a sensitive cell kinetic assay.
Biochemical pharmacology 1991;41(12):1903-9.
1990: M Poot; K Kausch; J Köhler; Thomas Haaf; Holger Hoehn
The minor-groove binding DNA-ligands netropsin, distamycin A and berenil cause polyploidisation via impairment of the G2 phase of the cell cycle.
Cell structure and function 1990;15(3):151-7.
1990: M Poot; H W Rüdiger; Holger Hoehn
Detection of free radical-induced DNA damage with bromodeoxyuridine/Hoechst flow cytometry: implications for Bloom's syndrome.
Mutation research 1990;238(3):203-7.
1990: M Poot; M Rizk-Rabin; Holger Hoehn; J H Pavlovitch
Cell size and RNA content correlate with cell differentiation and proliferative capacity of rat keratinocytes.
Journal of cellular physiology 1990;143(2):279-86.
1990: M Poot; J Koehler; Peter S Rabinovitch; Holger Hoehn; J H Priest
Cell kinetic disturbances induced by treatment of human diploid fibroblasts with 5-azacytidine indicate a major role for DNA methylation in the regulation of the chromosome cycle.
Human genetics 1990;84(3):258-62.
1990: M Poot; Holger Hoehn; M Kubbies; A Grossmann; Y C Chen; Peter S Rabinovitch
Cell cycle analysis using continuous bromodeoxyuridine labeling and Hoechst 33258-ethidium bromide bivariate flow cytometry.
Methods in cell biology 1990;33():185-98.
1990: M Kubbies; R Friedl; J Koehler; Peter S Rabinovitch; Holger Hoehn
Improvement of human lymphocyte proliferation and alteration of IL-2 secretion kinetics by alpha-thioglycerol.
Lymphokine research 1990;9(1):95-106.
1989: H Seyschab; R Friedl; Detlev Schindler; Holger Hoehn; Peter S Rabinovitch; U Chen
The effects of bacterial lipopolysaccharide, anti-receptor antibodies and recombinant interferon on mouse B cell cycle progression using 5-bromo-2'-deoxyuridine/Hoechst 33258 dye flow cytometry.
European journal of immunology 1989;19(9):1605-12.
1989: M Poot; Peter S Rabinovitch; Holger Hoehn
Bromodeoxyuridine amplifies free-radical-mediated DNA damage.
The Biochemical journal 1989;261(1):269-71.
1989: M Poot; H Schmitt; H Seyschab; J Koehler; U Chen; U Kaempf; M Kubbies; Detlev Schindler; Peter S Rabinovitch; Holger Hoehn
Continuous bromodeoxyuridine labeling and bivariate ethidium bromide/Hoechst flow cytometry in cell kinetics.
Cytometry 1989;10(2):222-6.
1989: M Poot; Holger Hoehn; T M Nicotera; H W Rüdiger
Cell kinetic evidence suggests elevated oxidative stress in cultured cells of Bloom's syndrome.
Free radical research communications 1989;7(3-6):179-87.
1989: M Poot; Peter S Rabinovitch; Holger Hoehn
Free radical mediated cytotoxicity of desferrioxamine.
Free radical research communications 1989;6(5):323-8.
1988: M Poot; H Esterbauer; Peter S Rabinovitch; Holger Hoehn
Disturbance of cell proliferation by two model compounds of lipid peroxidation contradicts causative role in proliferative senescence.
Journal of cellular physiology 1988;137(3):421-9.
1988: Detlev Schindler; Holger Hoehn
Fanconi anemia mutation causes cellular susceptibility to ambient oxygen.
American journal of human genetics 1988;43(4):429-35.
1988: M Poot; Detlev Schindler; M Kubbies; Holger Hoehn; Peter S Rabinovitch
Bromodeoxyuridine amplifies the inhibitory effect of oxygen on cell proliferation.
Cytometry 1988;9(4):332-8.
1988: W Heckl; J Köhler; Holger Hoehn; J Dämmrich
Characterization of a newly established human urinary bladder cancer cell line (BT-1).
Urological research 1988;16(1):23-9.
1987: Detlev Schindler; H Seyschab; M Poot; Holger Hoehn; A Schinzel; J P Fryns; Niels Tommerup; Peter S Rabinovitch
Screening test for ataxia telangiectasia.
Lancet 1987;2(8572):1398-9.
1987: Holger Hoehn; H Koch; J Köhler; T Bettecken; M Kubbies; W Heckl; D Salk; Peter S Rabinovitch
Interphase cell flow cytometry as a means of monitoring genomic size in normal and neoplastoid cell cultures.
Cancer genetics and cytogenetics 1987;24(2):191-204.
1987: M Kubbies; Holger Hoehn; Peter S Rabinovitch
Differences in growth factor sensitivity between primary and transformed murine cell cultures revealed by BrdU/Hoechst flow cytometry.
Experimental cell biology 1987;55(5):225-36.
1986: M Kubbies; R Friedl; T Bettecken; Holger Hoehn
The fate of the primary diploid population during spontaneous transformation of growth factor-supplemented murine cell cultures.
Cytometry 1986;7(6):551-7.