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Jan Hoeijmakers

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Alexander Y Maslov; Wilber Quispe-Tintaya; Erwin Reiling; Bennett Van Houten; Harry van Steeg; Martijn E T Dollé; Shireen Ganapathi; Paul Hasty; Jan H J Hoeijmakers; Maaike Westerhof; Ryan R White; Jan Vijg
DNA damage in normally and prematurely aged mice.
Erik L de Graaf; Monique C de Waard; A F Maarten Altelaar; Jan H J Hoeijmakers; Casper C Hoogenraad; Yvonne Rijksen; Ingrid van der Pluijm; Wilbert P Vermeij; Albert J R Heck
Spatio-temporal Analysis of Molecular Determinants of Neuronal Degeneration in the Aging Mouse Cerebellum.
Arjan F Theil; Marcel Vermeij; Jan de Wit; Jeroen Essers; Giuseppina Giglia-Mari; Jan H J Hoeijmakers; Charlène Lemaitre; Alex Maas; Pierre-Olivier Mari; Jurgen A Marteijn; Julie Nonnekens; Anja Raams; Barbara Steurer; Wim Vermeulen
Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality.

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All Publications

2013: Alexander Y Maslov; Wilber Quispe-Tintaya; Erwin Reiling; Bennett Van Houten; Harry van Steeg; Martijn E T Dollé; Shireen Ganapathi; Paul Hasty; Jan H J Hoeijmakers; Maaike Westerhof; Ryan R White; Jan Vijg
DNA damage in normally and prematurely aged mice.
Aging cell 2013;12(3):467-77.
2013: Erik L de Graaf; Monique C de Waard; A F Maarten Altelaar; Jan H J Hoeijmakers; Casper C Hoogenraad; Yvonne Rijksen; Ingrid van der Pluijm; Wilbert P Vermeij; Albert J R Heck
Spatio-temporal Analysis of Molecular Determinants of Neuronal Degeneration in the Aging Mouse Cerebellum.
Molecular & cellular proteomics : MCP 2013;12(5):1350-62.
2013: Arjan F Theil; Marcel Vermeij; Jan de Wit; Jeroen Essers; Giuseppina Giglia-Mari; Jan H J Hoeijmakers; Charlène Lemaitre; Alex Maas; Pierre-Olivier Mari; Jurgen A Marteijn; Julie Nonnekens; Anja Raams; Barbara Steurer; Wim Vermeulen
Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality.
PLoS genetics 2013;9(4):e1003431.
2012: Hervé Menoni; Jan H J Hoeijmakers; Wim Vermeulen
Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo.
The Journal of cell biology 2012;199(7):1037-46.
2012: Marieke van de Ven; Gijsbertus T J van der Horst; Jaan-Olle Andressoo; Jan H J Hoeijmakers; James R Mitchell
Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models.
DNA repair 2012;11(11):874-83.
2012: Hannes Lans; Jan H J Hoeijmakers
Genome stability, progressive kidney failure and aging.
Nature genetics 2012;44(8):836-8.
2012: Karin E M Diderich; Jan H J Hoeijmakers; Claudia Nicolaije; Matthias Priemel; Arndt F Schilling; Gijsbertus T J van der Horst; Sander M Botter; Renata M C Brandt; Judd S Day; Jan H Waarsing; Harrie Weinans; Johannes P T M van Leeuwen
Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice.
Age (Dordrecht, Netherlands) 2012;34(4):845-61.
2012: Petra Schwertman; Adriana C van der Hoek; Wim Vermeulen; Anja Raams; Dick H W Dekkers; Jeroen A A Demmers; Maria Fousteri; Jan H J Hoeijmakers; Charlie Laffeber; Anna Lagarou; Jurgen A Marteijn
UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.
Nature genetics 2012;44(5):598-602.
2012: Devashish Das; Gert E Folkers; Jan H J Hoeijmakers; Nicolaas G J Jaspers; Robert Kaptein; Marc van Dijk; Rolf Boelens
The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition.
Structure (London, England : 1993) 2012;20(4):667-75.
2012: Steven Bergink; Nico P Dantuma; Christoffel Dinant; Jan H J Hoeijmakers; Adriaan B Houtsmuller; Martijn S Luijsterburg; Wendy Toussaint; Sergey Alekseev; Wim Vermeulen
Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
The Journal of cell biology 2012;196(6):681-8.
2012: Marlene J Végh; Pim Van Nierop; Monique C de Waard; Jan H J Hoeijmakers; Ka Wan Li; Yanto Ridwan; Marion J M Sassen; August B Smit; Ingrid van der Pluijm; Roel C Van Der Schors; Ronald E van Kesteren
Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging.
Journal of proteome research 2012;11(3):1855-67.
2012: Marcella Spoor; Bart van Alphen; Ingrid van der Pluijm; Nils Z Borgesius; Maarten A Frens; Jan H J Hoeijmakers; A Paul Nagtegaal; Yanto Ridwan; J Gerard G Borst
Accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(δ/-) mouse.
Mechanisms of ageing and development 2012;133(2-3):59-67.
2012: Claudia Nicolaije; Matthias Priemel; Arndt F Schilling; B C J van der Eerden; Gijsbertus T J van der Horst; S M Botter; Renata M C Brandt; Judd S Day; Karin E M Diderich; Jan H J Hoeijmakers; Jan H Waarsing; Harrie Weinans; Johannes P T M van Leeuwen
Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice.
PloS one 2012;7(4):e35246.
2011: Maikel D Wouters; Dik C van Gent; Jan H J Hoeijmakers; Joris Pothof
MicroRNAs, the DNA damage response and cancer.
Mutation research 2011;717(1-2):54-66.
2011: Tessa M van Ginhoven; Conny van Holten-Neelen; James R Mitchell; Marja A Smits-te Nijenhuis; Ron W F de Bruin; Willem A Dik; Jan H J Hoeijmakers; Herbert Hooijkaas; Jan N M Ijzermans
Dietary restriction modifies certain aspects of the postoperative acute phase response.
The Journal of surgical research 2011;171(2):582-9.
2011: Mariëlle Verweij; Jan H J Hoeijmakers; Jan N M Ijzermans; James R Mitchell; Marieke van de Ven; Sandra van den Engel; Ron W F de Bruin
Glucose supplementation does not interfere with fasting-induced protection against renal ischemia/reperfusion injury in mice.
Transplantation 2011;92(7):752-8.
2011: Sander M Botter; Martijn E T Dollé; Jan H J Hoeijmakers; Gerjo J V M van Osch; Harry van Steeg; Harrie Weinans; Michel Zar; Johannes P T M van Leeuwen
Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy.
Age (Dordrecht, Netherlands) 2011;33(3):247-60.
2011: Nils Z Borgesius; Monique C de Waard; Jan H J Hoeijmakers; Dick Jaarsma; David W Melton; Azar Omrani; Gijsbertus T J van der Horst; Ingrid van der Pluijm; Gerben C M Zondag; Ype Elgersma
Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(35):12543-53.
2011: Mariëlle Verweij; Tessa M van Ginhoven; James R Mitchell; Wim Sluiter; Henk P Roest; Elham Torabi; Jan N M Ijzermans; Jan H J Hoeijmakers; Sandra van den Engel; Ron W F de Bruin
Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2011;17(6):695-704.
2011: Tessa M van Ginhoven; Ron W F de Bruin; Jan H J Hoeijmakers; James R Mitchell; Marijke Timmermans; Jan N M Ijzermans
Pre-operative dietary restriction is feasible in live-kidney donors.
Clinical transplantation 2011;25(3):486-94.
2011: Peter Krijger; Kyoo-Young Lee; Niek Wit; Paul van den Berk; Xiaoli Wu; Henk P Roest; Alex Maas; Hao Ding; Jan H J Hoeijmakers; Kyungjae Myung; Heinz Jacobs
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase.
DNA repair 2011;10(4):438-44.
2011: Martijn E T Dollé; Paul Hasty; Jan H J Hoeijmakers; Raoul V Kuiper; Laura J Niedernhofer; Joke Robinson; Marianne Roodbergen; Ingrid van der Pluijm; Rudolf B Beems; Liset de la Fonteyne; Sisca de Vlugt; Piet de With; Jan Vijg; Susan W P Wijnhoven; Harry van Steeg
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice.
Pathobiology of aging & age related diseases 2011;1():.
2011: Akiko Inagaki; Titia K Sixma; Esther Sleddens-Linkels; Wiggert A van Cappellen; J Anton Grootegoed; Richard G Hibbert; Jan H J Hoeijmakers; Willy M Baarends
Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.
PloS one 2011;6(8):e23155.
2010: Hugo Alves; Ursula Munoz-Najar; Jan De Wit; Auke J S Renard; Jan H J Hoeijmakers; John M Sedivy; Clemens Van Blitterswijk; Jan de Boer
A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells.
Journal of cellular and molecular medicine 2010;14(12):2729-38.
2010: Monique C de Waard; Ingrid van der Pluijm; Nils Zuiderveen Borgesius; Laura H Comley; Elize D Haasdijk; Yvonne Rijksen; Yanto Ridwan; Gerben Zondag; Jan H J Hoeijmakers; Ype Elgersma; Thomas H Gillingwater; Dick Jaarsma
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice.
Acta neuropathologica 2010;120(4):461-75.
2010: Hannes Lans; Jurgen A Marteijn; Björn Schumacher; Jan H J Hoeijmakers; Gert Jansen; Wim Vermeulen
Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development.
PLoS genetics 2010;6(5):e1000941.
2010: James R Mitchell; Mariëlle Verweij; Karl Brand; Marieke van de Ven; Natascha Goemaere; Sandra van den Engel; Timothy Chu; Flavio Forrer; Cristina Müller; Marion De Jong; Wilfred van IJcken; Jan N M Ijzermans; Jan H J Hoeijmakers; Ron W F de Bruin
Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice.
Aging cell 2010;9(1):40-53.
2009: Dik C van Gent; Jan H J Hoeijmakers
DNA double strand break repair: zooming in on the focus.
Cell cycle (Georgetown, Tex.) 2009;8(23):3813-5.
2009: Joris Pothof; Nicole S Verkaik; Jan H J Hoeijmakers; Dik C van Gent
MicroRNA responses and stress granule formation modulate the DNA damage response.
Cell cycle (Georgetown, Tex.) 2009;8(21):3462-8.
2009: Jan H J Hoeijmakers
DNA damage, aging, and cancer.
The New England journal of medicine 2009;361(15):1475-85.
2009: Giuseppina Giglia-Mari; Arjan F Theil; Pierre-Olivier Mari; Sophie Mourgues; Julie Nonnekens; Lise O Andrieux; Jan de Wit; Catherine Miquel; Nils Wijgers; Alex Maas; Maria Fousteri; Jan H J Hoeijmakers; Wim Vermeulen
Differentiation driven changes in the dynamic organization of Basal transcription initiation.
PLoS biology 2009;7(10):e1000220.
2009: Tessa M van Ginhoven; James R Mitchell; Marielle Verweij; Jan H J Hoeijmakers; Jan N M Ijzermans; Ron W F de Bruin
The use of preoperative nutritional interventions to protect against hepatic ischemia-reperfusion injury.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2009;15(10):1183-91.
2009: Joris Pothof; Nicole S Verkaik; Wilfred van IJcken; Erik A C Wiemer; Van T B Ta; Gijsbertus T J van der Horst; Nicolaas G J Jaspers; Dik C van Gent; Jan H J Hoeijmakers; Stephan P Persengiev
MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.
The EMBO journal 2009;28(14):2090-9.
2009: Ryotaro Nishi; Sergey Alekseev; Christoffel Dinant; Deborah Hoogstraten; Adriaan B Houtsmuller; Jan H J Hoeijmakers; Wim Vermeulen; Fumio Hanaoka; Kaoru Sugasawa
UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells.
DNA repair 2009;8(6):767-76.
2009: george garinis; Lieneke M Uittenboogaard; Heike Stachelscheid; Maria Fousteri; Wilfred van Ijcken; Timo M Breit; Harry van Steeg; Leon H F Mullenders; Gijsbertus T J van der Horst; Jens C Brüning; Carien M Niessen; Jan H J Hoeijmakers; Björn Schumacher
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.
Nature cell biology 2009;11(5):604-15.
2009: Denis Susa; James R Mitchell; Marielle Verweij; Marieke van de Ven; Henk Roest; Sandra van den Engel; Ingeborg M Bajema; Kirsten Mangundap; Jan N M Ijzermans; Jan H J Hoeijmakers; Ron W F de Bruin
Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice.
Aging cell 2009;8(2):192-200.
2009: Akiko Inagaki; Wiggert A van Cappellen; Roald van der Laan; Adriaan B Houtsmuller; Jan H J Hoeijmakers; J Anton Grootegoed; Willy M Baarends
Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair.
DNA repair 2009;8(2):190-201.
2008: Sergey Alekseev; Martijn S Luijsterburg; Alex Pines; Bart Geverts; Pierre-Olivier Mari; Giuseppina Giglia-Mari; Hannes Lans; Adriaan B Houtsmuller; Leon H F Mullenders; Jan H J Hoeijmakers; Wim Vermeulen
Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.
Molecular and cellular biology 2008;28(24):7402-13.
2008: George A Garinis; Gijsbertus T J van der Horst; Jan Vijg; Jan H J Hoeijmakers
DNA damage and ageing: new-age ideas for an age-old problem.
Nature cell biology 2008;10(11):1241-7.
2008: Harm de Waard; Edwin Sonneveld; Jan de Wit; Rebecca Esveldt-van Lange; Jan H J Hoeijmakers; Harry Vrieling; Gijsbertus T J van der Horst
Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.
DNA repair 2008;7(10):1659-69.
2008: Deborah Hoogstraten; Steven Bergink; Jessica M Y Ng; Vincent H M Verbiest; Martijn S Luijsterburg; Bart Geverts; Anja Raams; Christoffel Dinant; Jan H J Hoeijmakers; Wim Vermeulen; Adriaan B Houtsmuller
Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC.
Journal of cell science 2008;121(Pt 17):2850-9.
2008: Y Roche; D Zhang; G M J Segers-Nolten; Wim Vermeulen; Claire Wyman; K Sugasawa; Jan H J Hoeijmakers; Cees Otto
Fluorescence correlation spectroscopy of the binding of nucleotide excision repair protein XPC-hHr23B with DNA substrates.
Journal of fluorescence 2008;18(5):987-95.
2008: Akira Motegi; Hung-Jiun Liaw; Kyoo-Young Lee; Henk P Roest; Alex Maas; Xiaoli Wu; Helen Moinova; Sanford D Markowitz; Hao Ding; Jan H J Hoeijmakers; Kyungjae Myung
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(34):12411-6.
2008: Anwaar Ahmad; Andria Rasile Robinson; Anette Duensing; Ellen van Drunen; Berna Beverloo; David B Weisberg; Edward Hasty; Jan H J Hoeijmakers; Laura J Niedernhofer
ERCC1-XPF endonuclease facilitates DNA double-strand break repair.
Molecular and cellular biology 2008;28(16):5082-92.
2008: Joost P M Melis; Susan W P Wijnhoven; Rudolf B Beems; Marianne Roodbergen; Jolanda van den Berg; Hojin Moon; Errol Friedberg; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Jan Vijg; Harry van Steeg
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.
Cancer research 2008;68(5):1347-53.
2008: Devashish Das; Konstantinos Tripsianes; Nicolaas G J Jaspers; Jan H J Hoeijmakers; Robert Kaptein; Rolf Boelens; Gert E Folkers
The HhH domain of the human DNA repair protein XPF forms stable homodimers.
Proteins 2008;70(4):1551-63.
2008: Björn Schumacher; george garinis; Jan H J Hoeijmakers
Age to survive: DNA damage and aging.
Trends in genetics : TIG 2008;24(2):77-85.
2008: Björn Schumacher; Ingrid van der Pluijm; Michael J Moorhouse; Theodore Kosteas; Andria Rasile Robinson; Yousin Suh; Timo M Breit; Harry van Steeg; Laura J Niedernhofer; Wilfred van Ijcken; Andrzej Bartke; Stephen R Spindler; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; George A Garinis
Delayed and accelerated aging share common longevity assurance mechanisms.
PLoS genetics 2008;4(8):e1000161.
2007: Jan H J Hoeijmakers
Genome maintenance mechanisms are critical for preventing cancer as well as other aging-associated diseases.
Mechanisms of ageing and development 2007;128(7-8):460-2.
2007: Derrick J Rossi; David Bryder; Jun Seita; Andre Nussenzweig; Jan H J Hoeijmakers; Irving L Weissman
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.
Nature 2007;447(7145):725-9.
2007: Nicolaas G J Jaspers; Anja Raams; Margherita Silengo; Nils Wijgers; Laura J Niedernhofer; Andria Rasile Robinson; Giuseppina Giglia-Mari; Deborah Hoogstraten; Wim J Kleijer; Jan H J Hoeijmakers; Wim Vermeulen
First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
American journal of human genetics 2007;80(3):457-66.
2007: Theo G M F Gorgels; Ingrid van der Pluijm; Renata M C Brandt; george garinis; Harry van Steeg; Gerard van den Aardweg; Gerard H Jansen; Jan M Ruijter; Arthur A B Bergen; Dirk van Norren; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome.
Molecular and cellular biology 2007;27(4):1433-41.
2007: Ingrid van der Pluijm; george garinis; Renata M C Brandt; Theo G M F Gorgels; Susan W P Wijnhoven; Karin E M Diderich; Jan de Wit; James R Mitchell; Conny Th M van Oostrom; Rudolf B Beems; Laura J Niedernhofer; Susana Velasco; Errol C Friedberg; Kiyoji Tanaka; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
PLoS biology 2007;5(1):e2.
2007: Aart A van Apeldoorn; Jan de Boer; Harry van Steeg; Jan H J Hoeijmakers; Cees Otto; Clemens A van Blitterswijk
Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(1):34-40.
2007: Marieke van de Ven; Jaan-Olle Andressoo; Valerie B Holcomb; Edward Hasty; Yousin Suh; Harry van Steeg; george garinis; Jan H J Hoeijmakers; James R Mitchell
Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.
Mechanisms of ageing and development 2007;128(1):58-63.
2006: Laura J Niedernhofer; george garinis; Anja Raams; Astrid S Lalai; Andria Rasile Robinson; Esther Appeldoorn; Hanny Odijk; Roos Oostendorp; Anwaar Ahmad; Wibeke J van Leeuwen; Arjan F Theil; Wim Vermeulen; Gijsbertus T J van der Horst; Peter Meinecke; Wim J Kleijer; Jan Vijg; Nicolaas G J Jaspers; Jan H J Hoeijmakers
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
Nature 2006;444(7122):1038-43.
2006: Marieke van de Ven; Jaan-Olle Andressoo; Valerie B Holcomb; Marieke von Lindern; Willeke M C Jong; Chris I De Zeeuw; Yousin Suh; Edward Hasty; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; James R Mitchell
Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.
PLoS genetics 2006;2(12):e192.
2006: Jaan-Olle Andressoo; Jan H J Hoeijmakers; James R Mitchell
Nucleotide excision repair disorders and the balance between cancer and aging.
Cell cycle (Georgetown, Tex.) 2006;5(24):2886-8.
2006: Angelika Zotter; Martijn S Luijsterburg; Daniël O Warmerdam; Shehu Ibrahim; Alex L Nigg; Wiggert A van Cappellen; Jan H J Hoeijmakers; Roel Van Driel; Wim Vermeulen; Adriaan B Houtsmuller
Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH.
Molecular and cellular biology 2006;26(23):8868-79.
2006: Judith Jans; george garinis; Wouter Schul; Adri van Oudenaren; Michael J Moorhouse; Marcel Smid; Yurda-Gul Sert; Albertina van der Velde; Yvonne Rijksen; Frank R de Gruijl; Peter van der Spek; Akira Yasui; Jan H J Hoeijmakers; Pieter J M Leenen; Gijsbertus T J van der Horst
Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.
Molecular and cellular biology 2006;26(22):8515-26.
2006: Jaan-Olle Andressoo; Judith Jans; Jan de Wit; Frédéric Coin; Deborah Hoogstraten; Marieke van de Ven; Wendy Toussaint; Jan G M Huijmans; H Bing Thio; Wibeke J van Leeuwen; Jan de Boer; Jean-Marc Egly; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; James R Mitchell
Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.
PLoS biology 2006;4(10):e322.
2006: Steven Bergink; Lies-Anne Severijnen; Nils Wijgers; Kaoru Sugasawa; Humaira Yousaf; Johan M Kros; John C van Swieten; Ben A Oostra; Jan H J Hoeijmakers; Wim Vermeulen; Rob Willemsen
The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair.
Neurobiology of disease 2006;23(3):708-16.
2006: Jaan-Olle Andressoo; James R Mitchell; Jan de Wit; Deborah Hoogstraten; Marcel Volker; Wendy Toussaint; Ewoud Speksnijder; Rudolf B Beems; Harry van Steeg; Judith Jans; Chris I De Zeeuw; Nicolaas G J Jaspers; Anja Raams; Alan Lehmann; Wim Vermeulen; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.
Cancer cell 2006;10(2):121-32.
2006: Giuseppina Giglia-Mari; Catherine Miquel; Arjan F Theil; Pierre-Olivier Mari; Deborah Hoogstraten; Jessica M Y Ng; Christoffel Dinant; Jan H J Hoeijmakers; Wim Vermeulen
Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells.
PLoS biology 2006;4(6):e156.
2006: Steven Bergink; Florian A Salomons; Deborah Hoogstraten; Tom A M Groothuis; Harm de Waard; Junxin Wu; Li Yuan; Elisabetta Citterio; Adriaan B Houtsmuller; Jacques Neefjes; Jan H J Hoeijmakers; Wim Vermeulen; Nico P Dantuma
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.
Genes & development 2006;20(10):1343-52.
2006: Martijn E T Dollé; Rita A Busuttil; Ana Maria Garcia; Susan W P Wijnhoven; Ellen van Drunen; Laura J Niedernhofer; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Harry van Steeg; Jan Vijg
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.
Mutation research 2006;596(1-2):22-35.
2006: Stella A Martomo; William W Yang; Alexandra Vaisman; Alex Maas; Masayuki Yokoi; Jan H J Hoeijmakers; Fumio Hanaoka; Roger Woodgate; Patricia J Gearhart
Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota.
DNA repair 2006;5(3):392-8.
2006: Hannes Lans; Jan H J Hoeijmakers
Cell biology: ageing nucleus gets out of shape.
Nature 2006;440(7080):32-4.
2005: Laura J Niedernhofer; Astrid S Lalai; Jan H J Hoeijmakers
Fanconi anemia (cross)linked to DNA repair.
Cell 2005;123(7):1191-8.
2005: Konstantinos Tripsianes; Gert Folkers; Eiso Ab; Devashish Das; Hanny Odijk; Nicolaas G J Jaspers; Jan H J Hoeijmakers; Robert Kaptein; Rolf Boelens
The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair.
Structure (London, England : 1993) 2005;13(12):1849-58.
2005: Claude Backendorf; Jan de Wit; Marijke van Oosten; Gerdine J Stout; James R Mitchell; Anne-Marijke Borgstein; Gijsbertus T J van der Horst; Frank R de Gruijl; Jaap Brouwer; Leon H F Mullenders; Jan H J Hoeijmakers
Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice.
DNA repair 2005;4(11):1325-36.
2005: Susan W P Wijnhoven; Rudolf B Beems; Marianne Roodbergen; Jolanda van den Berg; Paul H M Lohman; Karin Diderich; Gijsbertus T J van der Horst; Jan Vijg; Jan H J Hoeijmakers; Harry van Steeg
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction.
DNA repair 2005;4(11):1314-24.
2005: george garinis; James R Mitchell; Michael J Moorhouse; Katsuhiro Hanada; Harm de Waard; Dimitri Vandeputte; Judith Jans; Karl Brand; Marcel Smid; Peter van der Spek; Jan H J Hoeijmakers; Roland Kanaar; Gijsbertus T J van der Horst
Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks.
The EMBO journal 2005;24(22):3952-62.
2005: Jaan-Olle Andressoo; Jan H J Hoeijmakers
Transcription-coupled repair and premature ageing.
Mutation research 2005;577(1-2):179-94.
2005: Emmanuel Compe; Pascal Drané; Camille Laurent; Karin Diderich; Cathy Braun; Jan H J Hoeijmakers; Jean-Marc Egly
Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations.
Molecular and cellular biology 2005;25(14):6065-76.
2005: Joanna M Prasher; Astrid S Lalai; Claudia Heijmans-Antonissen; Rob E Ploemacher; Jan H J Hoeijmakers; Ivo P Touw; Laura J Niedernhofer
Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice.
The EMBO journal 2005;24(4):861-71.
2005: Nancy Beerens; Jan H J Hoeijmakers; Roland Kanaar; Wim Vermeulen; Claire Wyman
The CSB protein actively wraps DNA.
The Journal of biological chemistry 2005;280(6):4722-9.
2005: Roald Laan; Willy M Baarends; Evelyne Wassenaar; Henk P Roest; Jan H J Hoeijmakers; J Anton Grootegoed
Expression and possible functions of DNA lesion bypass proteins in spermatogenesis.
International journal of andrology 2005;28(1):1-15.
2005: Willy M Baarends; Evelyne Wassenaar; Roald van der Laan; Jos W Hoogerbrugge; Esther Sleddens-Linkels; Jan H J Hoeijmakers; Peter de Boer; J Anton Grootegoed
Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.
Molecular and cellular biology 2005;25(3):1041-53.
2005: Jeroen Essers; Wiggert A van Cappellen; Arjan F Theil; Ellen van Drunen; Nicolaas G J Jaspers; Jan H J Hoeijmakers; Claire Wyman; Wim Vermeulen; Roland Kanaar
Dynamics of relative chromosome position during the cell cycle.
Molecular biology of the cell 2005;16(2):769-75.
2005: Judith Jans; Wouter Schul; Yurda-Gul Sert; Yvonne Rijksen; Heggert Rebel; Andre P M Eker; Satoshi Nakajima; Harry van Steeg; Frank R de Gruijl; Akira Yasui; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Powerful skin cancer protection by a CPD-photolyase transgene.
Current biology : CB 2005;15(2):105-15.
2005: Jaan-Olle Andressoo; Jan H J Hoeijmakers; Harm de Waard
Nucleotide excision repair and its connection with cancer and ageing.
Advances in experimental medicine and biology 2005;570():45-83.
2004: Martijn J Moné; Tytus Bernas; Christoffel Dinant; Feliks A Goedvree; Erik Manders; Marcel Volker; Adriaan B Houtsmuller; Jan H J Hoeijmakers; Wim Vermeulen; Roel Van Driel
In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(45):15933-7.
2004: Yuki Okuda; Ryotaro Nishi; Jessica M Y Ng; Wim Vermeulen; Gijsbertus T J van der Horst; Toshio Mori; Jan H J Hoeijmakers; Fumio Hanaoka; Kaoru Sugasawa
Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.
DNA repair 2004;3(10):1285-95.
2004: Roald van der Laan; Evert-Jan Uringa; Evelyne Wassenaar; Jos W Hoogerbrugge; Esther Sleddens; Hanny Odijk; Henk P Roest; Peter de Boer; Jan H J Hoeijmakers; J Anton Grootegoed; Willy M Baarends
Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.
Journal of cell science 2004;117(Pt 21):5023-33.
2004: Harm de Waard; Jan de Wit; Jaan-Olle Andressoo; Conny Th M van Oostrom; Bente Riis; Allan Weimann; Henrik E Poulsen; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.
Molecular and cellular biology 2004;24(18):7941-8.
2004: Magda Budzowska; Iris Jaspers; Jeroen Essers; Harm de Waard; Ellen van Drunen; Katsuhiro Hanada; Berna Beverloo; Rudolf W Hendriks; Annelies de Klein; Roland Kanaar; Jan H J Hoeijmakers; Alex Maas
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.
The EMBO journal 2004;23(17):3548-58.
2004: Carol E Schrader; Joycelyn Vardo; Erin K Linehan; Michael Z Twarog; Laura J Niedernhofer; Jan H J Hoeijmakers; Janet Stavnezer
Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.
The Journal of experimental medicine 2004;200(3):321-30.
2004: Vincent van den Boom; Elisabetta Citterio; Deborah Hoogstraten; Angelika Zotter; Jean-Marc Egly; Wiggert A van Cappellen; Jan H J Hoeijmakers; Adriaan B Houtsmuller; Wim Vermeulen
DNA damage stabilizes interaction of CSB with the transcription elongation machinery.
The Journal of cell biology 2004;166(1):27-36.
2004: Giuseppina Giglia-Mari; Frédéric Coin; Jeffrey A Ranish; Deborah Hoogstraten; Arjan F Theil; Nils Wijgers; Nicolaas G J Jaspers; Anja Raams; Manuela Argentini; Peter van der Spek; Elena Botta; Miria Stefanini; Jean-Marc Egly; Ruedi Aebersold; Jan H J Hoeijmakers; Wim Vermeulen
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.
Nature genetics 2004;36(7):714-9.
2004: Laura J Niedernhofer; Hanny Odijk; Magda Budzowska; Ellen van Drunen; Alex Maas; Arjan F Theil; Jan de Wit; Nicolaas G J Jaspers; Berna Beverloo; Jan H J Hoeijmakers; Roland Kanaar
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.
Molecular and cellular biology 2004;24(13):5776-87.
2004: Henk P Roest; Willy M Baarends; Jan de Wit; Jan W van Klaveren; Evelyne Wassenaar; Jos W Hoogerbrugge; Wiggert A van Cappellen; Jan H J Hoeijmakers; J Anton Grootegoed
The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.
Molecular and cellular biology 2004;24(12):5485-95.
2003: Eric Weterings; Nicole S Verkaik; Hennie T Brüggenwirth; Jan H J Hoeijmakers; Dik C van Gent
The role of DNA dependent protein kinase in synapsis of DNA ends.
Nucleic acids research 2003;31(24):7238-46.
2003: Xu-Dong Zhu; Laura Niedernhofer; Bernhard Kuster; Matthias Mann; Jan H J Hoeijmakers; Titia de Lange
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
Molecular cell 2003;12(6):1489-98.
2003: Karin E M Diderich; Jan H J Hoeijmakers; Johannes P T M van Leeuwen
Accelerated bone aging in the trichothiodystrophy mouse model.
The journals of gerontology. Series A, Biological sciences and medical sciences 2003;58(11):969.
2003: Wendy Kölgen; Harry van Steeg; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Willem A van Vloten; Frank R de Gruijl; Johan Garssen
Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.
The Journal of investigative dermatology 2003;121(4):751-6.
2003: Suzanne Rademakers; Marcel Volker; Deborah Hoogstraten; Alex L Nigg; Martijn J Moné; Albert A van Zeeland; Jan H J Hoeijmakers; Adriaan B Houtsmuller; Wim Vermeulen
Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions.
Molecular and cellular biology 2003;23(16):5755-67.
2003: Catherine Arnaudeau-Bégard; Florence Brellier; Odile Chevallier-Lagente; Jan H J Hoeijmakers; Françoise Bernerd; Alain Sarasin; Thierry Magnaldo
Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytes.
Human gene therapy 2003;14(10):983-96.
2003: Jessica M Y Ng; Wim Vermeulen; Gijsbertus T J van der Horst; Steven Bergink; Kaoru Sugasawa; Harry Vrieling; Jan H J Hoeijmakers
A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.
Genes & development 2003;17(13):1630-45.
2003: James R Mitchell; Jan H J Hoeijmakers; Laura J Niedernhofer
Divide and conquer: nucleotide excision repair battles cancer and ageing.
Current opinion in cell biology 2003;15(2):232-40.
2003: Ana Janićijević; Kaoru Sugasawa; Yuichiro Shimizu; Fumio Hanaoka; Nils Wijgers; Miodrag Djurica; Jan H J Hoeijmakers; Claire Wyman
DNA bending by the human damage recognition complex XPC-HR23B.
DNA repair 2003;2(3):325-36.
2003: Edward Hasty; Judith Campisi; Jan H J Hoeijmakers; Harry van Steeg; Jan Vijg
Aging and genome maintenance: lessons from the mouse?
Science (New York, N.Y.) 2003;299(5611):1355-9.
2003: Willy M Baarends; Evelyne Wassenaar; Jos W Hoogerbrugge; Gert van Cappellen; Henk P Roest; Jan Vreeburg; Marja Ooms; Jan H J Hoeijmakers; J Anton Grootegoed
Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.
Molecular and cellular biology 2003;23(4):1151-62.
2003: Harm de Waard; Jan de Wit; Theo G M F Gorgels; Gerard van den Aardweg; Jaan-Olle Andressoo; Marcel Vermeij; Harry van Steeg; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice.
DNA repair 2003;2(1):13-25.
2002: Nicolaas G J Jaspers; Anja Raams; Michael J Kelner; Jessica M Y Ng; yukiko yamashita; Shiunichi Takeda; Trevor C McMorris; Jan H J Hoeijmakers
Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.
DNA repair 2002;1(12):1027-38.
2002: Deborah Hoogstraten; Alex L Nigg; Helen Heath; Leon H F Mullenders; Roel Van Driel; Jan H J Hoeijmakers; Wim Vermeulen; Adriaan B Houtsmuller
Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo.
Molecular cell 2002;10(5):1163-74.
2002: G M J Segers-Nolten; Claire Wyman; Nils Wijgers; Wim Vermeulen; Aufried Lenferink; Jan H J Hoeijmakers; Jan Greve; Cees Otto
Scanning confocal fluorescence microscopy for single molecule analysis of nucleotide excision repair complexes.
Nucleic acids research 2002;30(21):4720-7.
2002: Jeroen Essers; Rudolf W Hendriks; Joanna Wesoly; Cecile E M T Beerens; Bep Smit; Jan H J Hoeijmakers; Claire Wyman; Mies L G Dronkert; Roland Kanaar
Analysis of mouse Rad54 expression and its implications for homologous recombination.
DNA repair 2002;1(10):779-93.
2002: Wouter Schul; Judith Jans; Yvonne Rijksen; Kyra H M Klemann; Andre P M Eker; Jan de Wit; Osamu Nikaido; Satoshi Nakajima; Akira Yasui; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice.
The EMBO journal 2002;21(17):4719-29.
2002: Masashi Takao; Shin-ichiro Kanno; Tatsuya Shiromoto; Rei Hasegawa; Hiroshi Ide; Shogo Ikeda; Altaf H Sarker; Shuji Seki; James Z Xing; X Chris Le; Michael Weinfeld; Kumiko Kobayashi; Jun-ichi Miyazaki; Manja Muijtjens; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; Akira Yasui; Altraf H Sarker
Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.
The EMBO journal 2002;21(13):3486-93.
2002: Jan de Boer; Jaan-Olle Andressoo; Jan de Wit; Jan G M Huijmans; Rudolf B Beems; Harry van Steeg; Geert Weeda; Gijsbertus T J van der Horst; Wibeke J van Leeuwen; Axel P N Themmen; Morteza Meradji; Jan H J Hoeijmakers
Premature aging in mice deficient in DNA repair and transcription.
Science (New York, N.Y.) 2002;296(5571):1276-9.
2002: Jeroen Essers; Adriaan B Houtsmuller; Lieneke R van Veelen; Coen C Paulusma; Alex L Nigg; Albert Pastink; Wim Vermeulen; Jan H J Hoeijmakers; Roland Kanaar
Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage.
The EMBO journal 2002;21(8):2030-7.
2002: Kazuhiro Yagita; Filippo Tamanini; Maya Yasuda; Jan H J Hoeijmakers; Gijsbertus T J van der Horst; Hitoshi Okamura
Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.
The EMBO journal 2002;21(6):1301-14.
2002: Nicole S Verkaik; Rebecca E E Esveldt-van Lange; Diana van Heemst; Hennie T Brüggenwirth; Jan H J Hoeijmakers; Malgorzata Z Zdzienicka; Dik C van Gent
Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.
European journal of immunology 2002;32(3):701-9.
2002: Gijsbertus T J van der Horst; Lisiane Meira; Theo G M F Gorgels; Jan de Wit; Susana Velasco-Miguel; James A Richardson; Yvonne Kamp; Maaike P G Vreeswijk; Bep Smit; Dirk Bootsma; Jan H J Hoeijmakers; Errol C Friedberg
UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.
DNA repair 2002;1(2):143-57.
2002: Jessica M Y Ng; Harry Vrieling; Kaoru Sugasawa; Marja Ooms; J Anton Grootegoed; Jan Vreeburg; Pim Visser; Rudolf B Beems; Theo G M F Gorgels; Fumio Hanaoka; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B.
Molecular and cellular biology 2002;22(4):1233-45.
2002: Shinya Kamiuchi; Masafumi Saijo; Elisabetta Citterio; Martijn de Jager; Jan H J Hoeijmakers; Kiyoji Tanaka
Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):201-6.
2001: Laura J Niedernhofer; Jeroen Essers; Geert Weeda; Berna Beverloo; Jan de Wit; Manja Muijtjens; Hanny Odijk; Jan H J Hoeijmakers; Roland Kanaar
The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells.
The EMBO journal 2001;20(22):6540-9.
2001: M Murai; Yasushi Enokido; N Inamura; Masafumi Yoshino; Yoshimichi Nakatsu; G T van der Horst; Jan H J Hoeijmakers; Keiichi Tanaka; Hiroshi Hatanaka
Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne syndrome Group B DNA repair genes.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13379-84.
2001: Marcel Volker; Martijn J Moné; parimal karmakar; Anneke Van Hoffen; W Schul; Wim Vermeulen; Jan H J Hoeijmakers; Roel Van Driel; Albert A van Zeeland; Leon H F Mullenders
Sequential assembly of the nucleotide excision repair factors in vivo.
Molecular cell 2001;8(1):213-24.
2001: A Boonstra; Adri van Oudenaren; Miranda Baert; Harry van Steeg; Pieter J M Leenen; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Huub F J Savelkoul; Johan Garssen
Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSB DNA repair-deficient mice.
The Journal of investigative dermatology 2001;117(1):141-6.
2001: Jan H J Hoeijmakers
Genome maintenance mechanisms for preventing cancer.
Nature 2001;411(6835):366-74.
2001: Dik C van Gent; Jan H J Hoeijmakers; Roland Kanaar
Chromosomal stability and the DNA double-stranded break connection.
Nature reviews. Genetics 2001;2(3):196-206.
2001: Wim Vermeulen; Suzanne Rademakers; Nicolaas G J Jaspers; Esther Appeldoorn; Anja Raams; B Klein; Wim J Kleijer; L K Hansen; Jan H J Hoeijmakers
A temperature-sensitive disorder in basal transcription and DNA repair in humans.
Nature genetics 2001;27(3):299-303.
2001: Jan H J Hoeijmakers
From xeroderma pigmentosum to the biological clock contributions of Dirk Bootsma to human genetics.
Mutation research 2001;485(1):43-59.
2001: Esther E A Verhoeven; Claire Wyman; Geri F Moolenaar; Jan H J Hoeijmakers; Nora Goosen
Architecture of nucleotide excision repair complexes: DNA is wrapped by UvrB before and after damage recognition.
The EMBO journal 2001;20(3):601-11.
2001: GS Winkler; Kaoru Sugasawa; Andre P M Eker; Wouter de Laat; Jan H J Hoeijmakers
Novel functional interactions between nucleotide excision DNA repair proteins influencing the enzymatic activities of TFIIH, XPG, and ERCC1-XPF.
Biochemistry 2001;40(1):160-5.
2000: T Seroz; GS Winkler; Jerome Auriol; Richard Verhage; Wim Vermeulen; B Smit; Jaap Brouwer; Andre P M Eker; Geert Weeda; Jean-Marc Egly; Jan H J Hoeijmakers
Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases.
Nucleic acids research 2000;28(22):4506-13.
2000: Yoshimichi Nakatsu; H Asahina; Elisabetta Citterio; Suzanne Rademakers; Wim Vermeulen; Shinya Kamiuchi; J P Yeo; M C Khaw; Masafumi Saijo; N Kodo; Toshio Matsuda; Jan H J Hoeijmakers; Keiichi Tanaka
XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription.
The Journal of biological chemistry 2000;275(45):34931-7.
2000: Wim Vermeulen; E Bergmann; Jerome Auriol; Suzanne Rademakers; Philippe Frit; Esther Appeldoorn; Jan H J Hoeijmakers; Jean-Marc Egly
Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder.
Nature genetics 2000;26(3):307-13.
2000: Roald van der Laan; Henk P Roest; Jos W Hoogerbrugge; Elisabeth M E Smit; Rosalyn Slater; Willy M Baarends; Jan H J Hoeijmakers; J Anton Grootegoed
Characterization of mRAD18Sc, a mouse homolog of the yeast postreplication repair gene RAD18.
Genomics 2000;69(1):86-94.
2000: Elisabetta Citterio; Vincent van den Boom; Gavin R Schnitzler; Roland Kanaar; E Bonte; Robert E Kingston; Jan H J Hoeijmakers; Wim Vermeulen
ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor.
Molecular and cellular biology 2000;20(20):7643-53.
2000: Mies L G Dronkert; Jan de Wit; M Boeve; M L Vasconcelos; Harry van Steeg; T L Raoul Tan; Jan H J Hoeijmakers; Roland Kanaar
Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.
Molecular and cellular biology 2000;20(13):4553-61.
2000: Johan Garssen; Harry van Steeg; Frank R de Gruijl; Jan de Boer; Gijsbertus T J van der Horst; Henk J van Kranen; Henk Van Loveren; M Van Dijk; A Fluitman; Geert Weeda; Jan H J Hoeijmakers
Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6199-205.
2000: Kazuhiro Yagita; Shun Yamaguchi; Filippo Tamanini; Gijsbertus T J van der Horst; Jan H J Hoeijmakers; Akira Yasui; Jennifer J Loros; Jay C Dunlap; Hitoshi Okamura
Dimerization and nuclear entry of mPER proteins in mammalian cells.
Genes & development 2000;14(11):1353-63.
2000: Elisabetta Citterio; Wim Vermeulen; Jan H J Hoeijmakers
Transcriptional healing.
Cell 2000;101(5):447-50.
2000: Mies L G Dronkert; Berna Beverloo; Roger D Johnson; Jan H J Hoeijmakers; Maria Jasin; Roland Kanaar
Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange.
Molecular and cellular biology 2000;20(9):3147-56.
2000: Annelies de Klein; Manja Muijtjens; RI van Os; Y Verhoeven; B Smit; A M Carr; Alan Lehmann; Jan H J Hoeijmakers
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.
Current biology : CB 2000;10(8):479-82.
2000: Jeroen Essers; Harry van Steeg; Jan de Wit; SM Swagemakers; Marcel Vermeij; Jan H J Hoeijmakers; Roland Kanaar
Homologous and non-homologous recombination differentially affect DNA damage repair in mice.
The EMBO journal 2000;19(7):1703-10.
2000: Jan de Boer; Jan H J Hoeijmakers
Nucleotide excision repair and human syndromes.
Carcinogenesis 2000;21(3):453-60.
2000: GS Winkler; S J Araújo; Ulrike Fiedler; Wim Vermeulen; Frédéric Coin; Jean-Marc Egly; Jan H J Hoeijmakers; Richard D Wood; H Th Marc Timmers; Geert Weeda
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
The Journal of biological chemistry 2000;275(6):4258-66.
1999: Hitoshi Okamura; S Miyake; Yasuo Sumi; Shun Yamaguchi; Akira Yasui; Manja Muijtjens; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock.
Science (New York, N.Y.) 1999;286(5449):2531-4.
1999: H Hiyama; Masayuki Yokoi; Chikahide Masutani; Kaoru Sugasawa; T Maekawa; Keiichi Tanaka; Jan H J Hoeijmakers; Fumio Hanaoka
Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome.
The Journal of biological chemistry 1999;274(39):28019-25.
1999: Jan de Boer; Gijsbertus T J van der Horst; Jan H J Hoeijmakers
[Mutant mice as a model of human diseases of aging. Defective transcription and premature aging].
Tijdschrift voor gerontologie en geriatrie 1999;30(4):168-70.
1999: Jan de Boer; Harry van Steeg; Rob J W Berg; Johan Garssen; Jan de Wit; C T van Oostrum; Rudolf B Beems; Gijsbertus T J van der Horst; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers; Geert Weeda
Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
Cancer research 1999;59(14):3489-94.
1999: Adriaan B Houtsmuller; Suzanne Rademakers; Alex L Nigg; Deborah Hoogstraten; Jan H J Hoeijmakers; Wim Vermeulen
Action of DNA repair endonuclease ERCC1/XPF in living cells.
Science (New York, N.Y.) 1999;284(5416):958-61.
1999: Brian Glassner; Geert Weeda; JM Allan; J L Broekhof; NH Carls; I Donker; Bevin P Engelward; R J Hampson; Remko Hersmus; Mark J Hickman; Richard B Roth; H B Warren; MM Wu; Jan H J Hoeijmakers; Leona D Samson
DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents.
Mutagenesis 1999;14(3):339-47.
1999: Gijsbertus T J van der Horst; Manja Muijtjens; Kumiko Kobayashi; R Takano; Shin-ichiro Kanno; Masashi Takao; Jan de Wit; A Verkerk; Andre P M Eker; Dik van Leenen; R Buijs; Dirk Bootsma; Jan H J Hoeijmakers; Akira Yasui
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.
Nature 1999;398(6728):627-30.
1999: Wouter de Laat; Nicolaas G J Jaspers; Jan H J Hoeijmakers
Molecular mechanism of nucleotide excision repair.
Genes & development 1999;13(7):768-85.
1999: T L Raoul Tan; Jeroen Essers; Elisabetta Citterio; SM Swagemakers; Jan de Wit; F E Benson; Jan H J Hoeijmakers; Roland Kanaar
Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation.
Current biology : CB 1999;9(6):325-8.
1999: Willy M Baarends; Jos W Hoogerbrugge; Henk P Roest; Marja Ooms; Jan Vreeburg; Jan H J Hoeijmakers; J Anton Grootegoed
Histone ubiquitination and chromatin remodeling in mouse spermatogenesis.
Developmental biology 1999;207(2):322-33.
1999: H A Bluyssen; Nicole C Naus; RI van Os; Iris Jaspers; Jan H J Hoeijmakers; Annelies de Klein
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Genomics 1999;55(2):219-28.
1998: H A Bluyssen; RI van Os; Nicole C Naus; Iris Jaspers; Jan H J Hoeijmakers; Annelies de Klein
A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene.
Genomics 1998;54(2):331-7.
1998: J Anton Grootegoed; Willy M Baarends; Henk P Roest; Jan H J Hoeijmakers
Knockout mouse model and gametogenic failure.
Molecular and cellular endocrinology 1998;145(1-2):161-6.
1998: SM Swagemakers; Jeroen Essers; Jan de Wit; Jan H J Hoeijmakers; Roland Kanaar
The human RAD54 recombinational DNA repair protein is a double-stranded DNA-dependent ATPase.
The Journal of biological chemistry 1998;273(43):28292-7.
1998: Wouter de Laat; AM Sijbers; Hanny Odijk; Nicolaas G J Jaspers; Jan H J Hoeijmakers
Mapping of interaction domains between human repair proteins ERCC1 and XPF.
Nucleic acids research 1998;26(18):4146-52.
1998: Wouter de Laat; Esther Appeldoorn; Kaoru Sugasawa; E Weterings; Nicolaas G J Jaspers; Jan H J Hoeijmakers
DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair.
Genes & development 1998;12(16):2598-609.
1998: Kaoru Sugasawa; Jessica M Y Ng; Chikahide Masutani; S Iwai; Peter van der Spek; Andre P M Eker; Fumio Hanaoka; Dirk Bootsma; Jan H J Hoeijmakers
Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair.
Molecular cell 1998;2(2):223-32.
1998: Jan de Boer; Jan de Wit; Harry van Steeg; Rob J W Berg; Hans Morreau; P Visser; Alan Lehmann; M Duran; Jan H J Hoeijmakers; Geert Weeda
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy.
Molecular cell 1998;1(7):981-90.
1998: Elisabetta Citterio; Suzanne Rademakers; Gijsbertus T J van der Horst; Alain van Gool; Jan H J Hoeijmakers; Wim Vermeulen
Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein.
The Journal of biological chemistry 1998;273(19):11844-51.
1998: Wouter de Laat; Esther Appeldoorn; Nicolaas G J Jaspers; Jan H J Hoeijmakers
DNA structural elements required for ERCC1-XPF endonuclease activity.
The Journal of biological chemistry 1998;273(14):7835-42.
1998: GS Winkler; Wim Vermeulen; Frédéric Coin; Jean-Marc Egly; Jan H J Hoeijmakers; Geert Weeda
Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein.
The Journal of biological chemistry 1998;273(2):1092-8.
1998: Geert Weeda; Jan de Boer; I Donker; Jan de Wit; S B Winkler; Gijsbertus T J van der Horst; Wim Vermeulen; Dirk Bootsma; Jan H J Hoeijmakers
Molecular basis of DNA repair mechanisms and syndromes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;154():147-55.
1998: Jan de Boer; I Donker; Jan de Wit; Jan H J Hoeijmakers; Geert Weeda
Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality.
Cancer research 1998;58(1):89-94.
1997: P Vichi; Frédéric Coin; Jean-Paul Renaud; Wim Vermeulen; Jan H J Hoeijmakers; Dino Moras; Jean-Marc Egly
Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP.
The EMBO journal 1997;16(24):7444-56.
1997: Kaoru Sugasawa; Jessica M Y Ng; Chikahide Masutani; T Maekawa; Akio Uchida; Peter van der Spek; Andre P M Eker; Suzanne Rademakers; C Visser; A Aboussekhra; Richard D Wood; Fumio Hanaoka; Dirk Bootsma; Jan H J Hoeijmakers
Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity.
Molecular and cellular biology 1997;17(12):6924-31.
1997: Chikahide Masutani; Marito Araki; Kaoru Sugasawa; Peter van der Spek; Ayumi Yamada; Akio Uchida; T Maekawa; Dirk Bootsma; Jan H J Hoeijmakers; Fumio Hanaoka
Identification and characterization of XPC-binding domain of hHR23B.
Molecular and cellular biology 1997;17(12):6915-23.
1997: Bevin P Engelward; Geert Weeda; Michael D Wyatt; J L Broekhof; Jan de Wit; I Donker; JM Allan; B Gold; Jan H J Hoeijmakers; Leona D Samson
Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13087-92.
1997: Alain van Gool; Elisabetta Citterio; Suzanne Rademakers; RI van Os; Wim Vermeulen; Angelos Constantinou; Jean-Marc Egly; Dirk Bootsma; Jan H J Hoeijmakers
The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.
The EMBO journal 1997;16(19):5955-65.
1997: Alain van Gool; Gijsbertus T J van der Horst; Elisabetta Citterio; Jan H J Hoeijmakers
Cockayne syndrome: defective repair of transcription?
The EMBO journal 1997;16(14):4155-62.
1997: Geert Weeda; M Rossignol; RA Fraser; GS Winkler; Wim Vermeulen; L J van 't Veer; L Ma; Jan H J Hoeijmakers; Jean-Marc Egly
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.
Nucleic acids research 1997;25(12):2274-83.
1997: Roland Kanaar; Jan H J Hoeijmakers
Recombination and joining: different means to the same ends.
Genes and function 1997;1(3):165-74.
1997: Geert Weeda; I Donker; Jan de Wit; Hans Morreau; R Janssens; C J Vissers; Alex L Nigg; Harry van Steeg; Dirk Bootsma; Jan H J Hoeijmakers
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.
Current biology : CB 1997;7(6):427-39.
1997: Gijsbertus T J van der Horst; Harry van Steeg; Rob J W Berg; Alain van Gool; Jan de Wit; Geert Weeda; Hans Morreau; Rudolf B Beems; Coen F van Kreijl; Frank R de Gruijl; Dirk Bootsma; Jan H J Hoeijmakers
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.
Cell 1997;89(3):425-35.
1997: Jeroen Essers; Rudolf W Hendriks; SM Swagemakers; C Troelstra; Jan de Wit; Dirk Bootsma; Jan H J Hoeijmakers; Roland Kanaar
Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination.
Cell 1997;89(2):195-204.
1997: David B Busch; H van Vuuren; Jan de Wit; A Collins; Malgorzata Z Zdzienicka; D L Mitchell; KW Brookman; M Stefanini; R Riboni; Larry H Thompson; Roberta B Albert; Alain van Gool; Jan H J Hoeijmakers
Phenotypic heterogeneity in nucleotide excision repair mutants of rodent complementation groups 1 and 4.
Mutation research 1997;383(2):91-106.
1997: JC Marinoni; R Roy; Wim Vermeulen; P Miniou; Yves Lutz; Geert Weeda; T Seroz; D M Gomez; Jan H J Hoeijmakers; Jean-Marc Egly
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.
The EMBO journal 1997;16(5):1093-102.
1997: Wim Vermeulen; Jan de Boer; Elisabetta Citterio; Alain van Gool; Gijsbertus T J van der Horst; Nicolaas G J Jaspers; Wouter de Laat; AM Sijbers; Peter van der Spek; Kaoru Sugasawa; Geert Weeda; GS Winkler; Dirk Bootsma; Jean-Marc Egly; Jan H J Hoeijmakers
Mammalian nucleotide excision repair and syndromes.
Biochemical Society transactions 1997;25(1):309-15.
1997: Geert Weeda; Eric Eveno; I Donker; Wim Vermeulen; O Chevallier-Lagente; A Taïeb; A Stary; Jan H J Hoeijmakers; M Mezzina; Alain Sarasin
A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy.
American journal of human genetics 1997;60(2):320-9.
1996: S Moriwaki; M Stefanini; Alan Lehmann; Jan H J Hoeijmakers; J H Robbins; Isabelle Rapin; Elena Botta; B Tanganelli; Wim Vermeulen; Bernard C Broughton; Kenneth H Kraemer
DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and cockayne syndrome resemble xeroderma pigmentosum cells.
The Journal of investigative dermatology 1996;107(4):647-53.
1996: AM Sijbers; Wouter de Laat; R R Ariza; M Biggerstaff; YF Wei; Jonathan G Moggs; K C Carter; BK Shell; E Evans; M C de Jong; Suzanne Rademakers; J de Rooij; Nicolaas G J Jaspers; Jan H J Hoeijmakers; Richard D Wood
Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease.
Cell 1996;86(5):811-22.
1996: Henk P Roest; J van Klaveren; Jan de Wit; C G van Gurp; Marcel Koken; M Vermey; J H van Roijen; Jos W Hoogerbrugge; Jan Vreeburg; Willy M Baarends; Dirk Bootsma; J Anton Grootegoed; Jan H J Hoeijmakers
Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.
Cell 1996;86(5):799-810.
1996: Michael McKay; C Troelstra; Peter van der Spek; Roland Kanaar; B Smit; Anne Hagemeijer; Dirk Bootsma; Jan H J Hoeijmakers
Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse.
Genomics 1996;36(2):305-15.
1996: AM Sijbers; Peter van der Spek; H Odijk; J van den Berg; M van Duin; A Westerveld; Nicolaas G J Jaspers; Dirk Bootsma; Jan H J Hoeijmakers
Mutational analysis of the human nucleotide excision repair gene ERCC1.
Nucleic acids research 1996;24(17):3370-80.
1996: Kaoru Sugasawa; Chikahide Masutani; Akio Uchida; T Maekawa; Peter van der Spek; Dirk Bootsma; Jan H J Hoeijmakers; F Hanaoka
HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro.
Molecular and cellular biology 1996;16(9):4852-61.
1996: J R Hwang; V Moncollin; Wim Vermeulen; T Seroz; H van Vuuren; Jan H J Hoeijmakers; Jean-Marc Egly
A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
The Journal of biological chemistry 1996;271(27):15898-904.
1996: Roland Kanaar; C Troelstra; SM Swagemakers; Jeroen Essers; B Smit; J H Franssen; Albert Pastink; Olga Bezzubova; Jean-Marie Buerstedde; B Clever; Wolf-Dietrich Heyer; Jan H J Hoeijmakers
Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation.
Current biology : CB 1996;6(7):828-38.
1996: Peter van der Spek; Andre P M Eker; Suzanne Rademakers; C Visser; Kaoru Sugasawa; Chikahide Masutani; F Hanaoka; Dirk Bootsma; Jan H J Hoeijmakers
XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.
Nucleic acids research 1996;24(13):2551-9.
1996: Xin Wei Wang; Wim Vermeulen; JD Coursen; M Gibson; Shawn E Lupold; K Forrester; G Xu; L Elmore; H Yeh; Jan H J Hoeijmakers; Curtis C Harris
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.
Genes & development 1996;10(10):1219-32.
1996: Jan H J Hoeijmakers; Jean-Marc Egly; Wim Vermeulen
TFIIH: a key component in multiple DNA transactions.
Current opinion in genetics & development 1996;6(1):26-33.
1996: Richard Verhage; Alain van Gool; N de Groot; Jan H J Hoeijmakers; P van de Putte; Jaap Brouwer
Double mutants of Saccharomyces cerevisiae with alterations in global genome and transcription-coupled repair.
Molecular and cellular biology 1996;16(2):496-502.
1996: Marcel Koken; Jos W Hoogerbrugge; I Jasper-Dekker; Jan de Wit; R Willemsen; Henk P Roest; J Anton Grootegoed; Jan H J Hoeijmakers
Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification.
Developmental biology 1996;173(1):119-32.
1996: Peter van der Spek; C E Visser; F Hanaoka; B Smit; Anne Hagemeijer; Dirk Bootsma; Jan H J Hoeijmakers
Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene RAD23.
Genomics 1996;31(1):20-7.
1995: L Ma; Jan H J Hoeijmakers; Alex J van der Eb
Mammalian nucleotide excision repair.
Biochimica et biophysica acta 1995;1242(2):137-63.
1995: Xin Wei Wang; M K Gibson; Wim Vermeulen; H Yeh; K Forrester; H W Stürzbecher; Jan H J Hoeijmakers; Curtis C Harris
Abrogation of p53-induced apoptosis by the hepatitis B virus X gene.
Cancer research 1995;55(24):6012-6.
1995: Eric Eveno; F Bourre; X Quilliet; O Chevallier-Lagente; L Roza; Andre P M Eker; W J Kleijer; O Nikaido; M Stefanini; Jan H J Hoeijmakers
Different removal of ultraviolet photoproducts in genetically related xeroderma pigmentosum and trichothiodystrophy diseases.
Cancer research 1995;55(19):4325-32.
1995: P J Hendriksen; Jos W Hoogerbrugge; Axel P N Themmen; Marcel Koken; Jan H J Hoeijmakers; Ben A Oostra; T van der Lende; J Anton Grootegoed
Postmeiotic transcription of X and Y chromosomal genes during spermatogenesis in the mouse.
Developmental biology 1995;170(2):730-3.
1995: A J van Vuuren; Esther Appeldoorn; H Odijk; S Humbert; V Moncollin; Andre P M Eker; Nicolaas G J Jaspers; Jean-Marc Egly; Jan H J Hoeijmakers
Partial characterization of the DNA repair protein complex, containing the ERCC1, ERCC4, ERCC11 and XPF correcting activities.
Mutation research 1995;337(1):25-39.
1995: N G Jaspers; Jan H J Hoeijmakers
DNA repair. Nucleotide excision-repair in the test tube.
Current biology : CB 1995;5(7):700-2.
1995: M Carreau; Eric Eveno; X Quilliet; O Chevalier-Lagente; A Benoit; B Tanganelli; M Stefanini; Wim Vermeulen; Jan H J Hoeijmakers; Alain Sarasin
Development of a new easy complementation assay for DNA repair deficient human syndromes using cloned repair genes.
Carcinogenesis 1995;16(5):1003-9.
1995: Dirk Bootsma; Geert Weeda; Wim Vermeulen; H van Vuuren; C Troelstra; Peter van der Spek; Jan H J Hoeijmakers
Nucleotide excision repair syndromes: molecular basis and clinical symptoms.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1995;347(1319):75-81.
1995: Bernard C Broughton; A F Thompson; S A Harcourt; Wim Vermeulen; Jan H J Hoeijmakers; Elena Botta; M Stefanini; M D King; C A Weber; J Cole
Molecular and cellular analysis of the DNA repair defect in a patient in xeroderma pigmentosum complementation group D who has the clinical features of xeroderma pigmentosum and Cockayne syndrome.
American journal of human genetics 1995;56(1):167-74.
1994: R Roy; J P Adamczewski; T Seroz; Wim Vermeulen; J P Tassan; L Schaeffer; E A Nigg; Jan H J Hoeijmakers; Jean-Marc Egly
The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor.
Cell 1994;79(6):1093-101.
1994: Alain van Gool; Richard Verhage; SM Swagemakers; P van de Putte; Jaap Brouwer; C Troelstra; Dirk Bootsma; Jan H J Hoeijmakers
RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6.
The EMBO journal 1994;13(22):5361-9.
1994: D F Muris; Olga Bezzubova; Jean-Marie Buerstedde; Kees Vreeken; Adayabalam S Balajee; C J Osgood; C Troelstra; Jan H J Hoeijmakers; K Ostermann; H Schmidt
Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination.
Mutation research 1994;315(3):295-305.
1994: Peter van der Spek; Elisabeth M E Smit; Berna Beverloo; Kaoru Sugasawa; Chikahide Masutani; F Hanaoka; Jan H J Hoeijmakers; Anne Hagemeijer
Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23.
Genomics 1994;23(3):651-8.
1994: M Mezzina; Eric Eveno; O Chevallier-Lagente; A Benoit; M Carreau; Wim Vermeulen; Jan H J Hoeijmakers; M Stefanini; Alan Lehmann; C A Weber
Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells.
Carcinogenesis 1994;15(8):1493-8.
1994: D Busch; C Greiner; K L Rosenfeld; R Ford; Jan de Wit; Jan H J Hoeijmakers; Larry H Thompson
Complementation group assignments of moderately UV-sensitive CHO mutants isolated by large-scale screening (FAECB).
Mutagenesis 1994;9(4):301-6.
1994: L Ma; A Westbroek; Aart G Jochemsen; G Weeda; A Bosch; D Bootsma; Jan H J Hoeijmakers; Alex J van der Eb
Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function.
Molecular and cellular biology 1994;14(6):4126-34.
1994: S Humbert; H van Vuuren; Yves Lutz; Jan H J Hoeijmakers; Jean-Marc Egly; V Moncollin
p44 and p34 subunits of the BTF2/TFIIH transcription factor have homologies with SSL1, a yeast protein involved in DNA repair.
The EMBO journal 1994;13(10):2393-8.
1994: L Schaeffer; V Moncollin; R Roy; A Staub; M Mezzina; Alain Sarasin; Geert Weeda; Jan H J Hoeijmakers; Jean-Marc Egly
The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.
The EMBO journal 1994;13(10):2388-92.
1994: Dirk Bootsma; Jan H J Hoeijmakers
The molecular basis of nucleotide excision repair syndromes.
Mutation research 1994;307(1):15-23.
1994: S Keeney; Andre P M Eker; T Brody; Wim Vermeulen; Dirk Bootsma; Jan H J Hoeijmakers; Stuart Linn
Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):4053-6.
1994: A J van Vuuren; Wim Vermeulen; L Ma; Geert Weeda; Esther Appeldoorn; Nicolaas G J Jaspers; A J van der Eb; Dirk Bootsma; Jan H J Hoeijmakers; S Humbert
Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH).
The EMBO journal 1994;13(7):1645-53.
1994: Wim Vermeulen; R J Scott; S Rodgers; H J Müller; J Cole; C F Arlett; Wim J Kleijer; Dirk Bootsma; Jan H J Hoeijmakers; Geert Weeda
Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3.
American journal of human genetics 1994;54(2):191-200.
1994: Jan H J Hoeijmakers
Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies.
European journal of cancer (Oxford, England : 1990) 1994;30A(13):1912-21.
1993: M Stefanini; Wim Vermeulen; Geert Weeda; S Giliani; Tiziana Nardo; M Mezzina; Alain Sarasin; J I Harper; C F Arlett; Jan H J Hoeijmakers
A new nucleotide-excision-repair gene associated with the disorder trichothiodystrophy.
American journal of human genetics 1993;53(4):817-21.
1993: Marcel Koken; H H Odijk; M van Duin; Maarten Fornerod; Jan H J Hoeijmakers
Augmentation of protein production by a combination of the T7 RNA polymerase system and ubiquitin fusion: overproduction of the human DNA repair protein, ERCC1, as a ubiquitin fusion protein in Escherichia coli.
Biochemical and biophysical research communications 1993;195(2):643-53.
1993: A J van Vuuren; Esther Appeldoorn; H Odijk; Akira Yasui; Nicolaas G J Jaspers; Dirk Bootsma; Jan H J Hoeijmakers
Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F.
The EMBO journal 1993;12(9):3693-701.
1993: Wim Vermeulen; J Jaeken; Nicolaas G J Jaspers; Dirk Bootsma; Jan H J Hoeijmakers
Xeroderma pigmentosum complementation group G associated with Cockayne syndrome.
American journal of human genetics 1993;53(1):185-92.
1993: Jan H J Hoeijmakers
Nucleotide excision repair. II: From yeast to mammals.
Trends in genetics : TIG 1993;9(6):211-7.
1993: M Molinete; Wim Vermeulen; Alexander Bürkle; Josiane Ménissier-de Murcia; JH Küpper; Jan H J Hoeijmakers; Gilbert de Murcia
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.
The EMBO journal 1993;12(5):2109-17.
1993: Jan H J Hoeijmakers
Nucleotide excision repair I: from E. coli to yeast.
Trends in genetics : TIG 1993;9(5):173-7.
1993: L Schaeffer; R Roy; S Humbert; V Moncollin; Wim Vermeulen; Jan H J Hoeijmakers; Pierre Chambon; Jean-Marc Egly
DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor.
Science (New York, N.Y.) 1993;260(5104):58-63.
1993: Geert Weeda; Jan H J Hoeijmakers; Dirk Bootsma
Genes controlling nucleotide excision repair in eukaryotic cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 1993;15(4):249-58.
1993: C Troelstra; W Hesen; Dirk Bootsma; Jan H J Hoeijmakers
Structure and expression of the excision repair gene ERCC6, involved in the human disorder Cockayne's syndrome group B.
Nucleic acids research 1993;21(3):419-26.
1992: C Troelstra; Alain van Gool; Jan de Wit; Wim Vermeulen; Dirk Bootsma; Jan H J Hoeijmakers
ERCC6, a member of a subfamily of putative helicases, is involved in Cockayne's syndrome and preferential repair of active genes.
Cell 1992;71(6):939-53.
1992: E Park; Sami Guzder; Marcel Koken; I Jaspers-Dekker; Geert Weeda; Jan H J Hoeijmakers; Satya Prakash; Louise Prakash
RAD25 (SSL2), the yeast homolog of the human xeroderma pigmentosum group B DNA repair gene, is essential for viability.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11416-20.
1992: Marcel Koken; C Vreeken; S A Bol; N C Cheng; I Jaspers-Dekker; Jan H J Hoeijmakers; Jan C J Eeken; Geert Weeda; Albert Pastink
Cloning and characterization of the Drosophila homolog of the xeroderma pigmentosum complementation-group B correcting gene, ERCC3.
Nucleic acids research 1992;20(21):5541-8.
1992: Andre P M Eker; Wim Vermeulen; N Miura; K Tanaka; Nicolaas G J Jaspers; Jan H J Hoeijmakers; Dirk Bootsma
Xeroderma pigmentosum group A correcting protein from calf thymus.
Mutation research 1992;274(3):211-24.
1992: C Troelstra; R M Landsvater; J Wiegant; M van der Ploeg; G Viel; Charles H C M Buys; Jan H J Hoeijmakers
Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21.
Genomics 1992;12(4):745-9.
1992: Marcel Koken; Elisabeth M E Smit; I Jaspers-Dekker; Ben A Oostra; Anne Hagemeijer; Dirk Bootsma; Jan H J Hoeijmakers
Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31.
Genomics 1992;12(3):447-53.
1992: L Ma; G Weeda; Aart G Jochemsen; D Bootsma; Jan H J Hoeijmakers; Alex J van der Eb
Molecular and functional analysis of the XPBC/ERCC-3 promoter: transcription activity is dependent on the integrity of an Sp1-binding site.
Nucleic acids research 1992;20(2):217-24.
1992: Alan Lehmann; Jan H J Hoeijmakers; A A van Zeeland; C M Backendorf; Bryn A Bridges; A Collins; Robert Fuchs; G P Margison; R Montesano; Ethel Moustacchi
Workshop on DNA repair.
Mutation research 1992;273(1):1-28.
1991: Jan H J Hoeijmakers
How relevant is the Escherichia coli UvrABC model for excision repair in eukaryotes?
Journal of cell science 1991;100 (Pt 4)():687-91.
1991: Geert Weeda; L Ma; R C van Ham; Dirk Bootsma; Alex J van der Eb; Jan H J Hoeijmakers
Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome.
Carcinogenesis 1991;12(12):2361-8.
1991: Geert Weeda; L B Ma; R C van Ham; Alex J van der Eb; Jan H J Hoeijmakers
Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome.
Nucleic acids research 1991;19(22):6301-8.
1991: P B Belt; M F van Oosterwijk; H Odijk; Jan H J Hoeijmakers; Claude Backendorf
Induction of a mutant phenotype in human repair proficient cells after overexpression of a mutated human DNA repair gene.
Nucleic acids research 1991;19(20):5633-7.
1991: Marcel Koken; P Reynolds; I Jaspers-Dekker; Louise Prakash; Satya Prakash; Dirk Bootsma; Jan H J Hoeijmakers
Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(20):8865-9.
1991: P B Belt; W Jongmans; J de Wit; Jan H J Hoeijmakers; P van de Putte; Claude Backendorf
Efficient cDNA cloning by direct phenotypic correction of a mutant human cell line (HPRT-) using an Epstein-Barr virus-derived cDNA expression vector.
Nucleic acids research 1991;19(18):4861-6.
1991: Wim Vermeulen; M Stefanini; S Giliani; Jan H J Hoeijmakers; Dirk Bootsma
Xeroderma pigmentosum complementation group H falls into complementation group D.
Mutation research 1991;255(2):201-8.
1991: Geert Weeda; J Wiegant; M van der Ploeg; A H Geurts van Kessel; Alex J van der Eb; Jan H J Hoeijmakers
Localization of the xeroderma pigmentosum group B-correcting gene ERCC3 to human chromosome 2q21.
Genomics 1991;10(4):1035-40.
1991: Marcel Koken; P Reynolds; Dirk Bootsma; Jan H J Hoeijmakers; Satya Prakash; Louise Prakash
Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(9):3832-6.
1991: Dirk Bootsma; Jan H J Hoeijmakers
The genetic basis of xeroderma pigmentosum.
Annales de génétique 1991;34(3-4):143-50.
1990: C Troelstra; H Odijk; Jan de Wit; A Westerveld; L H Thompson; Dirk Bootsma; Jan H J Hoeijmakers
Molecular cloning of the human DNA excision repair gene ERCC-6.
Molecular and cellular biology 1990;10(11):5806-13.
1990: Jan H J Hoeijmakers; Andre P M Eker; Richard D Wood; P Robins
Use of in vivo and in vitro assays for the characterization of mammalian excision repair and isolation of repair proteins.
Mutation research 1990;236(2-3):223-38.
1990: Geert Weeda; R C van Ham; Wim Vermeulen; Dirk Bootsma; Alex J van der Eb; Jan H J Hoeijmakers
A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome.
Cell 1990;62(4):777-91.
1990: Geert Weeda; R C van Ham; R Masurel; A Westerveld; H Odijk; Jan de Wit; Dirk Bootsma; Alex J van der Eb; Jan H J Hoeijmakers
Molecular cloning and biological characterization of the human excision repair gene ERCC-3.
Molecular and cellular biology 1990;10(6):2570-81.
1990: P Reynolds; Marcel Koken; Jan H J Hoeijmakers; Satya Prakash; Louise Prakash
The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae.
The EMBO journal 1990;9(5):1423-30.
1990: Gérard Gradwohl; Josiane Ménissier-de Murcia; M Molinete; Frédéric Simonin; Marcel Koken; Jan H J Hoeijmakers; Gilbert de Murcia
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):2990-4.
1990: L Roza; Wim Vermeulen; J B Bergen Henegouwen; Andre P M Eker; Nicolaas G J Jaspers; Paul H M Lohman; Jan H J Hoeijmakers
Effects of microinjected photoreactivating enzyme on thymine dimer removal and DNA repair synthesis in normal human and xeroderma pigmentosum fibroblasts.
Cancer research 1990;50(6):1905-10.
1989: M van Duin; J van Den Tol; Jan H J Hoeijmakers; Dirk Bootsma; I P Rupp; P Reynolds; Louise Prakash; Satya Prakash
Conserved pattern of antisense overlapping transcription in the homologous human ERCC-1 and yeast RAD10 DNA repair gene regions.
Molecular and cellular biology 1989;9(4):1794-8.
1989: M van Duin; G Vredeveldt; L V Mayne; H Odijk; Wim Vermeulen; B Klein; Geert Weeda; Jan H J Hoeijmakers; Dirk Bootsma; A Westerveld
The cloned human DNA excision repair gene ERCC-1 fails to correct xeroderma pigmentosum complementation groups A through I.
Mutation research 1989;217(2):83-92.
1989: W Keijzer; M P Mulder; J C Langeveld; Elisabeth M E Smit; J L Bos; Dirk Bootsma; Jan H J Hoeijmakers
Establishment and characterization of a melanoma cell line from a xeroderma pigmentosum patient: activation of N-ras at a potential pyrimidine dimer site.
Cancer research 1989;49(5):1229-35.
1988: M van Duin; J van den Tol; PG Warmerdam; H Odijk; Dies Meijer; A Westerveld; Dirk Bootsma; Jan H J Hoeijmakers
Evolution and mutagenesis of the mammalian excision repair gene ERCC-1.
Nucleic acids research 1988;16(12):5305-22.
1988: M van Duin; J H Janssen; Jan de Wit; Jan H J Hoeijmakers; L H Thompson; Dirk Bootsma; A Westerveld
Transfection of the cloned human excision repair gene ERCC-1 to UV-sensitive CHO mutants only corrects the repair defect in complementation group-2 mutants.
Mutation research 1988;193(2):123-30.
1987: M van Duin; Marcel Koken; J van den Tol; Peter ten Dijke; H Odijk; A Westerveld; Dirk Bootsma; Jan H J Hoeijmakers
Genomic characterization of the human DNA excision repair gene ERCC-1.
Nucleic acids research 1987;15(22):9195-213.
1987: Jan H J Hoeijmakers; H Odijk; A Westerveld
Differences between rodent and human cell lines in the amount of integrated DNA after transfection.
Experimental cell research 1987;169(1):111-9.
1987: Jan H J Hoeijmakers
Characterization of genes and proteins involved in excision repair of human cells.
Journal of cell science. Supplement 1987;6():111-25.
1986: J C Zwetsloot; A P Barbeiro; Wim Vermeulen; H M Arthur; Jan H J Hoeijmakers; C Backendorf
Microinjection of Escherichia coli UvrA, B, C and D proteins into fibroblasts of xeroderma pigmentosum complementation groups A and C does not result in restoration of UV-induced unscheduled DNA synthesis.
Mutation research 1986;166(1):89-98.
1986: M van Duin; Jan de Wit; H Odijk; A Westerveld; A Yasui; Marcel Koken; Jan H J Hoeijmakers; Dirk Bootsma
Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10.
Cell 1986;44(6):913-23.
1985: J C Zwetsloot; Wim Vermeulen; Jan H J Hoeijmakers; Akira Yasui; Andre P M Eker; Dirk Bootsma
Microinjected photoreactivating enzymes from Anacystis and Saccharomyces monomerize dimers in chromatin of human cells.
Mutation research 1985;146(1):71-7.
1984: A Westerveld; Jan H J Hoeijmakers; M van Duin; Jan de Wit; H Odijk; A Pastink; R D Wood; Dirk Bootsma
Molecular cloning of a human DNA repair gene.
Nature 1984;310(5976):425-9.