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Dieter Hoelzer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Busse Antonia; Gökbuget Nicola; Siehl Jan Michael; Hoelzer Dieter; Schwartz Stefan; Rietz Anika; Thiel Eckhard; Keilholz Ulrich
Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome.
Baldus Claudia D; Thibaut Julia; Goekbuget Nicola; Stroux Andrea; Schlee Cornelia; Mossner Max; Burmeister Thomas; Schwartz Stefan; Bloomfield Clara D; Hoelzer Dieter; Thiel Eckhard; Hofmann Wolf-Karsten
Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia.
Kelly Jennifer L; Toothaker Stephen R; Ciminello Lauren; Hoelzer Dieter; Holte Harald; LaCasce Ann S; Mead Graham; Thomas Deborah; Van Imhoff Gustaaf W; Kahl Brad S; Cheson Bruce D; Magrath Ian T; Fisher Richard I; Friedberg Jonathan W
Outcomes of patients with burkitt lymphoma older than age 40 treated with intensive chemotherapeutic regimens.

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All Publications

2009: Busse Antonia; Gökbuget Nicola; Siehl Jan Michael; Hoelzer Dieter; Schwartz Stefan; Rietz Anika; Thiel Eckhard; Keilholz Ulrich
Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome.
Annals of hematology 2009;88(12):1199-205.
2009: Baldus Claudia D; Thibaut Julia; Goekbuget Nicola; Stroux Andrea; Schlee Cornelia; Mossner Max; Burmeister Thomas; Schwartz Stefan; Bloomfield Clara D; Hoelzer Dieter; Thiel Eckhard; Hofmann Wolf-Karsten
Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia.
Haematologica 2009;94(10):1383-90.
2009: Kelly Jennifer L; Toothaker Stephen R; Ciminello Lauren; Hoelzer Dieter; Holte Harald; LaCasce Ann S; Mead Graham; Thomas Deborah; Van Imhoff Gustaaf W; Kahl Brad S; Cheson Bruce D; Magrath Ian T; Fisher Richard I; Friedberg Jonathan W
Outcomes of patients with burkitt lymphoma older than age 40 treated with intensive chemotherapeutic regimens.
Clinical lymphoma & myeloma 2009;9(4):307-10.
2009: Burmeister Thomas; Meyer Claus; Schwartz Stefan; Hofmann Julia; Molkentin Mara; Kowarz Eric; Schneider Björn; Raff Thorsten; Reinhardt Richard; Gökbuget Nicola; Hoelzer Dieter; Thiel Eckhard; Marschalek Rolf
The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.
Blood 2009;113(17):4011-5.
2009: Hopfer Olaf; Komor Martina; Koehler Ina Sabine; Freitag Claudia; Schulze Matthias; Hoelzer Dieter; Thiel Eckhard; Hofmann Wolf-Karsten
Aberrant promotor methylation in MDS hematopoietic cells during in vitro lineage specific differentiation is differently associated with DNMT isoforms.
Leukemia research 2009;33(3):434-42.
2009: Fischer Lars; Gökbuget Nicola; Schwartz Stefan; Burmeister Thomas; Rieder Harald; Brüggemann Monika; Hoelzer Dieter; Thiel Eckhard
CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy.
Haematologica 2009;94(2):224-9.
2009: Hoelzer Dieter; Gökbuget Nicola
T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity?
Clinical lymphoma & myeloma 2009;9 Suppl 3():S214-21.
2008: Burmeister Thomas; Schwartz Stefan; Bartram Claus R; Gökbuget Nicola; Hoelzer Dieter; Thiel Eckhard;
Patients' age and BCR-ABL frequency in adult B-precursor ALL: a retrospective analysis from the GMALL study group.
Blood 2008;112(3):918-9.
2008: Oriol Albert; Ribera Josep-Maria; Bergua Juan; Giménez Mesa Eduardo; Grande Carlos; Esteve Jordi; Brunet Salut; Moreno Maria-Jose; Escoda Lourdes; Hernandez-Rivas Jesus-Maria; Hoelzer Dieter
High-dose chemotherapy and immunotherapy in adult Burkitt lymphoma: comparison of results in human immunodeficiency virus-infected and noninfected patients.
Cancer 2008;113(1):117-25.
2008: Baak U; Gökbuget N; Orawa H; Schwartz S; Hoelzer D; Thiel E; Burmeister T;
Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2008;22(6):1154-60.
2007: Furman Richard R; Hoelzer Dieter
Purine nucleoside phosphorylase inhibition as a novel therapeutic approach for B-cell lymphoid malignancies.
Seminars in oncology 2007;34(6 Suppl 5):S29-34.
2007: Burmeister Thomas; Schwartz Stefan; Taubald Almut; Jost Edgar; Lipp Thomas; Schneller Folker; Diedrich Helmut; Thomssen Henrike; Mey Ulrich J M; Eucker Jan; Rieder Harald; Gökbuget Nicola; Hoelzer Dieter; Thiel Eckhard
Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.
Haematologica 2007;92(12):1699-702.
2007: Bug Gesine; Anargyrou Konstantinos; Tonn Torsten; Bialleck Heike; Seifried Erhard; Hoelzer Dieter; Ottmann Oliver G
Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis.
Transfusion 2007;47(10):1843-50.
2007: Nowak Daniel; Boehrer Simone; Hochmuth Simone; Trepohl Bettina; Hofmann Wencke; Hoelzer Dieter; Hofmann Wolf-Karsten; Mitrou Paris S; Ruthardt Martin; Chow Kai Uwe
Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.
Anti-cancer drugs 2007;18(9):981-95.
2007: Baldus Claudia D; Martus Peter; Burmeister Thomas; Schwartz Stefan; Gökbuget Nicola; Bloomfield Clara D; Hoelzer Dieter; Thiel Eckhard; Hofmann Wolf K
Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(24):3739-45.
2007: Brück P; Mousset S; Bühme A; Hoelzer D; Atta J
Nonsecretory primary plasma cell leukemia with good response to thalidomide-based treatment.
International journal of hematology 2007;86(1):66-8.
2007: Chow Kai Uwe; Nowak Daniel; Trepohl Bettina; Hochmuth Simone; Schneider Bernd; Hoelzer Dieter; Mitrou Paris S; Bergmann Lothar; Ottmann Oliver Gerhard; Boehrer Simone
The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines.
Leukemia & lymphoma 2007;48(7):1379-88.
2007: Pfeifer Heike; Wassmann Barbara; Pavlova Anna; Wunderle Lydia; Oldenburg Johannes; Binckebanck Anja; Lange Thoralf; Hochhaus Andreas; Wystub Silvia; Brück Patrick; Hoelzer Dieter; Ottmann Oliver G
Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).
Blood 2007;110(2):727-34.
2007: Ott Marion G; Seger Reinhard; Stein Stefan; Siler Ulrich; Hoelzer Dieter; Grez Manuel
Advances in the treatment of Chronic Granulomatous Disease by gene therapy.
Current gene therapy 2007;7(3):155-61.
2007: Hopfer Olaf; Komor Martina; Koehler Ina Sabine; Schulze Matthias; Hoelzer Dieter; Thiel Eckhard; Hofmann Wolf-Karsten
DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation.
Experimental hematology 2007;35(5):712-23.
2007: Ottmann Oliver G; Wassmann Barbara; Pfeifer Heike; Giagounidis Aristoteles; Stelljes Matthias; Dührsen Ulrich; Schmalzing Marc; Wunderle Lydia; Binckebanck Anja; Hoelzer Dieter;
Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).
Cancer 2007;109(10):2068-76.
2007: Bug Gesine; Schwarz Kerstin; Schoch Claudia; Kampfmann Manuela; Henschler Reinhard; Hoelzer Dieter; Ottmann Oliver G; Ruthardt Martin
Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.
Haematologica 2007;92(4):542-5.
2007: Zheng Xiaomin; Seshire Anita; Rüster Brigitte; Bug Gesine; Beissert Tim; Puccetti Elena; Hoelzer Dieter; Henschler Reinhard; Ruthardt Martin
Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.
Haematologica 2007;92(3):323-31.
2007: Atta Johannes; Chow Kai U; Weidmann Eckhart; Mitrou Paris S; Hoelzer Dieter; Martin Hans
Dexa-BEAM as salvage therapy in patients with primary refractory aggressive non-Hodgkin lymphoma.
Leukemia & lymphoma 2007;48(2):349-56.
2007: Raff Thorsten; Gökbuget Nicola; Lüschen Silke; Reutzel Regina; Ritgen Matthias; Irmer Sebastian; Böttcher Sebastian; Horst Heinz-August; Kneba Michael; Hoelzer Dieter; Brüggemann Monika;
Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials.
Blood 2007;109(3):910-5.
2007: Burmeister Thomas; Schwartz Stefan; Hummel Michael; Hoelzer Dieter; Thiel Eckhard
No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms.
Retrovirology 2007;4():11.
2006: Hoelzer Dieter
Advances in the management of Ph-positive ALL.
Clinical advances in hematology & oncology : H&O 2006;4(11):804-5.
2006: Burmeister Thomas; Gökbuget Nicola; Reinhardt Richard; Rieder Harald; Hoelzer Dieter; Schwartz Stefan
NUP214-ABL1 in adult T-ALL: the GMALL study group experience.
Blood 2006;108(10):3556-9.
2006: Hofmann W-K; Takeuchi S; Takeuchi N; Thiel E; Hoelzer D; Koeffler H P
Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome.
Leukemia research 2006;30(11):1347-53.
2006: Saussele S; Adam K; Hochhaus A; Béné M C; Büchner T; Burnett A; Finazzi G; Fonatsch C; Gluckman E; Gökbuget N; Grimwade D J; Haferlach T; Hallek M; Hasford J; Hoelzer D; Ljungman P; Niederwieser D; Serve H; Simonsson B; de Witte T J; Hehlmann R;
[Clinical research at the European LeukemiaNet]
Deutsche medizinische Wochenschrift (1946) 2006;131(43):2423-6.
2006: Baldus Claudia D; Burmeister Thomas; Martus Peter; Schwartz Stefan; Gökbuget Nicola; Bloomfield Clara D; Hoelzer Dieter; Thiel Eckhard; Hofmann Wolf K
High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(29):4714-20.
2006: Hoffmann Christian; Wolf Eva; Wyen Christoph; Fätkenheuer Gerd; Van Lunzen Jan; Stellbrink Hans-Juergen; Stoehr Albrecht; Plettenberg Andreas; Jaeger Hans; Noppeney Richard; Hentrich Marcus; Goekbuget Nicola; Hoelzer Dieter; Horst Heinz-August
AIDS-associated Burkitt or Burkitt-like lymphoma: short intensive polychemotherapy is feasible and effective.
Leukemia & lymphoma 2006;47(9):1872-80.
2006: Wassmann Barbara; Pfeifer Heike; Goekbuget Nicola; Beelen Dietrich W; Beck Joachim; Stelljes Matthias; Bornhäuser Martin; Reichle Albrecht; Perz Jolanta; Haas Rainer; Ganser Arnold; Schmid Mathias; Kanz Lothar; Lenz Georg; Kaufmann Martin; Binckebanck Anja; Brück Patrick; Reutzel Regina; Gschaidmeier Harald; Schwartz Stefan; Hoelzer Dieter; Ottmann Oliver G
Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).
Blood 2006;108(5):1469-77.
2006: Kantarjian Hagop; Giles Francis; Wunderle Lydia; Bhalla Kapil; O'Brien Susan; Wassmann Barbara; Tanaka Chiaki; Manley Paul; Rae Patricia; Mietlowski William; Bochinski Kathy; Hochhaus Andreas; Griffin James D; Hoelzer Dieter; Albitar Maher; Dugan Margaret; Cortes Jorge; Alland Leila; Ottmann Oliver G
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL.
The New England journal of medicine 2006;354(24):2542-51.
2006: Saussele Susanne; Berger Ute; Aul Carlo; Büchner Thomas; Döhner Hartmut; Ehninger Gerhard; Ganser Arnold; Gökbuget Nicola; Hoelzer Dieter; Uberla Karl; Hehlmann Rüdiger
[Clinical research within the German competence net "acute and chronic leukemias"]
Medizinische Klinik (Munich, Germany : 1983) 2006;101(5):414-20.
2006: Boehrer Simone; Nowak Daniel; Puccetti Elena; Ruthardt Martin; Sattler Nicole; Trepohl Bettina; Schneider Bernd; Hoelzer Dieter; Mitrou Paris S; Chow Kai Uwe
Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.
Leukemia research 2006;30(5):597-605.
2006: Koyama Noriko; Koschmieder Steffen; Tyagi Sandhya; Portero-Robles Ignacio; Chromic Jörg; Myloch Silke; Nürnberger Heike; Rossmanith Tanja; Hofmann Wolf-Karsten; Hoelzer Dieter; Ottmann Oliver Gerhard
Inhibition of phosphotyrosine phosphatase 1B causes resistance in BCR-ABL-positive leukemia cells to the ABL kinase inhibitor STI571.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2025-31.
2006: Ott Marion G; Schmidt Manfred; Schwarzwaelder Kerstin; Stein Stefan; Siler Ulrich; Koehl Ulrike; Glimm Hanno; Kühlcke Klaus; Schilz Andrea; Kunkel Hana; Naundorf Sonja; Brinkmann Andrea; Deichmann Annette; Fischer Marlene; Ball Claudia; Pilz Ingo; Dunbar Cynthia; Du Yang; Jenkins Nancy A; Copeland Neal G; Lüthi Ursula; Hassan Moustapha; Thrasher Adrian J; Hoelzer Dieter; von Kalle Christof; Seger Reinhard; Grez Manuel
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Nature medicine 2006;12(4):401-9.
2006: Burmeister T; Marschalek R; Schneider B; Meyer C; Gökbuget N; Schwartz S; Hoelzer D; Thiel E
Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(3):451-7.
2006: Heil G; Hoelzer D; Sanz M A; Lechner K; Noens L; Szer J; Ganser A; Matcham J; Renwick J;
Long-term survival data from a phase 3 study of Filgrastim as an adjunct to chemotherapy in adults with de novo acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(3):404-9.
2006: Brüggemann Monika; Raff Thorsten; Flohr Thomas; Gökbuget Nicola; Nakao Makoto; Droese Jo; Lüschen Silke; Pott Christiane; Ritgen Matthias; Scheuring Urban; Horst Heinz-August; Thiel Eckhard; Hoelzer Dieter; Bartram Claus R; Kneba Michael;
Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia.
Blood 2006;107(3):1116-23.
2006: Chow Kai Uwe; Nowak Daniel; Kim Soo-Zin; Schneider Bernd; Komor Martina; Boehrer Simone; Mitrou Paris S; Hoelzer Dieter; Weidmann Eckhart; Hofmann Wolf-Karsten
In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling.
Pharmacological research : the official journal of the Italian Pharmacological Society 2006;53(1):49-61.
2006: Gökbuget Nicola; Hoelzer Dieter
Treatment of adult acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2006;():133-41.
2006: Gökbuget Nicola; Hoelzer Dieter
Novel antibody-based therapy for acute lymphoblastic leukaemia.
Best practice & research. Clinical haematology 2006;19(4):701-13.
2006: Boehrer Simone; Nowak Daniel; Hoelzer Dieter; Mitrou Paris S; Chow Kai Uwe
The molecular biology of TRAIL-mediated signaling and its potential therapeutic exploitation in hematopoietic malignancies.
Current medicinal chemistry 2006;13(18):2091-100.
2006: Boehrer Simone; Nowak Daniel; Hoelzer Dieter; Mitrou Paris S; Chow Kai Uwe
Novel agents aiming at specific molecular targets increase chemosensitivity and overcome chemoresistance in hematopoietic malignancies.
Current pharmaceutical design 2006;12(1):111-28.
2005: Bug Gesine; Ritter Markus; Wassmann Barbara; Schoch Claudia; Heinzel Thorsten; Schwarz Kerstin; Romanski Annette; Kramer Oliver H; Kampfmann Manuela; Hoelzer Dieter; Neubauer Andreas; Ruthardt Martin; Ottmann Oliver G
Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia.
Cancer 2005;104(12):2717-25.
2005: Gleissner Beate; Goekbuget Nicola; Rieder Harald; Arnold Renate; Schwartz Stefan; Diedrich Helmut; Schoch Claudia; Heinze Barbara; Fonatsch Christa; Bartram Claus R; Hoelzer Dieter; Thiel Eckhard;
CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL).
Blood 2005;106(13):4054-6.
2005: Bug Gesine; Atta Johannes; Klein Stefan A; Hertenstein Bernd; Bergmann Lothar; Boehrer Simone; Mousset Sabine; Hoelzer Dieter; Martin Hans
High-dose melphalan is an effective salvage therapy in acute myeloid leukaemia patients with refractory relapse and relapse after autologous stem cell transplantation.
Annals of hematology 2005;84(11):748-54.
2005: Mousset Sabine; Hermann Stella; Klein Stefan A; Bialleck Heike; Duchscherer Michaele; Bomke Barbara; Wassmann Barbara; Böhme Angelika; Hoelzer Dieter; Martin Hans
Prophylactic and interventional granulocyte transfusions in patients with haematological malignancies and life-threatening infections during neutropenia.
Annals of hematology 2005;84(11):734-41.
2005: Komor Martina; Güller Saskia; Baldus Claudia D; de Vos Sven; Hoelzer Dieter; Ottmann Oliver G; Hofmann Wolf-K
Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation.
Stem cells (Dayton, Ohio) 2005;23(8):1154-69.
2005: Burmeister T; Schwartz S; Horst H-A; Rieder H; Gökbuget N; Hoelzer D; Thiel E
Molecular heterogeneity of sporadic adult Burkitt-type leukemia/lymphoma as revealed by PCR and cytogenetics: correlation with morphology, immunology and clinical features.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2005;19(8):1391-8.
2005: Bartolovic Kerol; Balabanov Stefan; Berner Birgit; Bühring Hans-Jörg; Komor Martina; Becker Sven; Hoelzer Dieter; Kanz Lothar; Hofmann Wolf-Karsten; Brümmendorf Tim H
Clonal heterogeneity in growth kinetics of CD34+CD38- human cord blood cells in vitro is correlated with gene expression pattern and telomere length.
Stem cells (Dayton, Ohio) 2005;23(7):946-57.
2005: Puccetti Elena; Zheng Xiaomin; Brambilla Daria; Seshire Anita; Beissert Tim; Boehrer Simone; Nürnberger Heike; Hoelzer Dieter; Ottmann Oliver Gerhard; Nervi Clara; Ruthardt Martin
The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.
Cancer research 2005;65(14):6080-8.
2005: Wassmann Barbara; Pfeifer Heike; Stadler Michael; Bornhaüser Martin; Bug Gesine; Scheuring Urban J; Brück Patrick; Stelljes Matthias; Schwerdtfeger Rainer; Basara Nadezda; Perz Jolanta; Bunjes Donald; Ledderose Georg; Mahlberg Rolf; Binckebanck Anja; Gschaidmeier Harald; Hoelzer Dieter; Ottmann Oliver G
Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).
Blood 2005;106(2):458-63.
2005: Rummel Mathias J; Al-Batran Salah E; Kim Soo-Z; Welslau Manfred; Hecker Ralf; Kofahl-Krause Dorothea; Josten Klaus-M; Dürk Heinz; Rost Andreas; Neise Michael; von Grünhagen Ulrich; Chow Kai U; Hansmann Martin-L; Hoelzer Dieter; Mitrou Paris S
Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(15):3383-9.
2005: Boehrer Simone; Nowak Daniel; Hochmuth Simone; Kim Soo-Zin; Trepohl Bettina; Afkir Amina; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart; Chow Kai Uwe
Daxx overexpression in T-lymphoblastic Jurkat cells enhances caspase-dependent death receptor- and drug-induced apoptosis in distinct ways.
Cellular signalling 2005;17(5):581-95.
2005: Bug Gesine; Gül Hilal; Schwarz Kerstin; Pfeifer Heike; Kampfmann Manuela; Zheng Xiaomin; Beissert Tim; Boehrer Simone; Hoelzer Dieter; Ottmann Oliver Gerhard; Ruthardt Martin
Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells.
Cancer research 2005;65(7):2537-41.
2005: Boehrer Simone; Nowak Daniel; Kukoc-Zivojnov Natasa; Hochmuth Simone; Kim Soo-Zin; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart; Chow Kai Uwe
Expression of Daxx sensitizes Jurkat T-cells to the apoptosis-inducing effect of chemotherapeutic agents.
Pharmacological research : the official journal of the Italian Pharmacological Society 2005;51(4):367-74.
2005: Romanski Annette; Bug Gesine; Becker Sven; Kampfmann Manuela; Seifried Erhard; Hoelzer Dieter; Ottmann Oliver G; Tonn Torsten
Mechanisms of resistance to natural killer cell-mediated cytotoxicity in acute lymphoblastic leukemia.
Experimental hematology 2005;33(3):344-52.
2005: Arndt U; Kaltwasser J P; Gottschalk R; Hoelzer D; Möller B
Correction of iron-deficient erythropoiesis in the treatment of anemia of chronic disease with recombinant human erythropoietin.
Annals of hematology 2005;84(3):159-66.
2005: Wolf Timo; Brodt Hans-Reinhard; Fichtlscherer Stephan; Mantzsch Kathleen; Hoelzer Dieter; Helm Eilke B; Mitrou Paris S; Chow Kai Uwe
Changing incidence and prognostic factors of survival in AIDS-related non-Hodgkin's lymphoma in the era of highly active antiretroviral therapy (HAART).
Leukemia & lymphoma 2005;46(2):207-15.
2004: Hehlmann R; Berger U; Aul C; Büchner Th; Döhner H; Ehninger G; Ganser A; Gökbuget N; Hoelzer D; Uberla K
[The competence network "acute and chronic leukemias"]
Deutsche medizinische Wochenschrift (1946) 2004;129(49):2660-5.
2004: Brück Patrick; Wassmann Barbara; Lopez Elizabeth Ramos; Hoelzer Dieter; Ottmann Oliver G
Development of hygromas or severe edema during treatment with the tyrosine kinase inhibitor STI571 is not associated with platelet-derived growth factor receptor (PDGFR) gene polymorphisms.
Leukemia research 2004;28(11):1153-7.
2004: Boehrer Simone; Kukoc-Zivojnov Natasa; Nowak Daniel; Bergmann Marion; Baum Christine; Puccetti Elena; Weidmann Eckhart; Hoelzer Dieter; Mitrou Paris S; Chow Kai Uwe
Upon drug-induced apoptosis expression of prostate-apoptosis-response-gene-4 promotes cleavage of caspase-8, bid and mitochondrial release of cytochrome c.
Hematology (Amsterdam, Netherlands) 2004;9(5-6):425-31.
2004: Kim Soo-Zin; Chow Kai Uwe; Kukoc-Zivojnov Natasa; Boehrer Simone; Brieger Angela; Steimle-Grauer Susanne Annette; Harder Lana; Hoelzer Dieter; Mitrou Paris Sophokles; Weidmann Eckhart
Expression of ZAP-70 protein correlates with disease stage in chronic lymphocytic leukemia and is associated with, but not generally restricted to, non-mutated Ig VH status.
Leukemia & lymphoma 2004;45(10):2037-45.
2004: Bergmann Marion; Kukoc-Zivojnov Natasa; Chow Kai U; Trepohl Bettina; Hoelzer Dieter; Weidmann Eckhart; Mitrou Paris S; Boehrer Simone
Prostate apoptosis response gene-4 sensitizes neoplastic lymphocytes to CD95-induced apoptosis.
Annals of hematology 2004;83(10):646-53.
2004: Mahlknecht Ulrich; Will Jutta; Varin Audrey; Hoelzer Dieter; Herbein Georges
Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3979-90.
2004: Hofmann W K; Heil G; Zander C; Wiebe S; Ottmann O G; Bergmann L; Hoeffken K; Fischer J T; Knuth A; Kolbe K; Schmoll H J; Langer W; Westerhausen M; Koelbel C B; Hoelzer D; Ganser A
Intensive chemotherapy with idarubicin, cytarabine, etoposide, and G-CSF priming in patients with advanced myelodysplastic syndrome and high-risk acute myeloid leukemia.
Annals of hematology 2004;83(8):498-503.
2004: Boehrer Simone; Brieger Angela; Schaaf Simone; Kukoc-Zivojnov Natasa; Nowak Daniel; Ruthardt Martin; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart; Chow Kai Uwe
In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis.
Leukemia & lymphoma 2004;45(7):1445-51.
2004: Nowak Daniel; Boehrer Simone; Brieger Angela; Kim Soo-Zin; Schaaf Simone; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart; Chow Kai Uwe
Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus.
Leukemia & lymphoma 2004;45(7):1429-36.
2004: Kiehl Michael G; Kraut Ludwig; Schwerdtfeger Rainer; Hertenstein Bernd; Remberger Mats; Kroeger Nicolaus; Stelljes Mathias; Bornhaeuser Martin; Martin Hans; Scheid Christoph; Ganser Arnold; Zander Axel R; Kienast Joachim; Ehninger Gerhard; Hoelzer Dieter; Diehl Volker; Fauser Axel A; Ringden Olle
Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(14):2816-25.
2004: Kukoc-Zivojnov Natasa; Puccetti Elena; Chow Kai U; Bergmann Marion; Ruthardt Martin; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart; Boehrer Simone
Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells.
Experimental hematology 2004;32(7):649-56.
2004: Brieger Angela; Boehrer Simone; Schaaf Simone; Nowak Daniel; Ruthardt Martin; Kim Soo-Zin; Atadja Peter; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart; Chow Kai Uwe
In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.
Biochemical pharmacology 2004;68(1):85-93.
2004: Heil G; Krauter J; Raghavachar A; Bergmann L; Hoelzer D; Fiedler W; Lübbert M; Noens L; Schlimok G; Arnold R; Kirchner H; Ganser A
Risk-adapted induction and consolidation therapy in adults with de novo AML aged </= 60 years: results of a prospective multicenter trial.
Annals of hematology 2004;83(6):336-44.
2004: Armitage James O; Tobinai Kensei; Hoelzer Dieter; Rummel Mathias J
Treatment of indolent non-Hodgkin's lymphoma with cladribine as single-agent therapy and in combination with mitoxantrone.
International journal of hematology 2004;79(4):311-21.
2004: Zheng Xiaomin; Beissert Tim; Kukoc-Zivojnov Natasa; Puccetti Elena; Altschmied Joachim; Strolz Corinna; Boehrer Simone; Gul Hilal; Schneider Orinta; Ottmann Oliver Gerhard; Hoelzer Dieter; Henschler Reinhard; Ruthardt Martin
Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.
Blood 2004;103(9):3535-43.
2004: Hofmann Wolf-K; Komor Martina; Hoelzer Dieter; Ottmann Oliver G
Mechanisms of resistance to STI571 (Imatinib) in Philadelphia-chromosome positive acute lymphoblastic leukemia.
Leukemia & lymphoma 2004;45(4):655-60.
2004: Romanski Annette; Bacic Biserka; Bug Gesine; Pfeifer Heike; Gul Hilal; Remiszewski Stacy; Hoelzer Dieter; Atadja Peter; Ruthardt Martin; Ottmann Oliver G
Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.
Haematologica 2004;89(4):419-26.
2004: Hehlmann R; Berger U; Aul C; Büchner T; Döhner H; Ehninger G; Ganser A; Hoelzer D; Gökbuget N; Uberla K
[Clinical research in the "acute and chronic leukemias"competence network ]
Der Internist 2004;45(4):384-92.
2004: Brüggemann M; van der Velden V H J; Raff T; Droese J; Ritgen M; Pott C; Wijkhuijs A J; Gökbuget N; Hoelzer D; van Wering E R; van Dongen J J M; Kneba M
Rearranged T-cell receptor beta genes represent powerful targets for quantification of minimal residual disease in childhood and adult T-cell acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(4):709-19.
2004: Gökbuget Nicola; Hoelzer Dieter
Treatment with monoclonal antibodies in acute lymphoblastic leukemia: current knowledge and future prospects.
Annals of hematology 2004;83(4):201-5.
2004: Koyama Noriko; Hoelzer Dieter; Ottmann Oliver G
Regulation of human IL-18 gene expression: interaction of PU.1 with GC-box binding protein is involved in human IL-18 expression in myeloid cells.
European journal of immunology 2004;34(3):817-26.
2004: Wassmann Barbara; Pfeifer Heike; Scheuring Urban J; Binckebanck Anja; Gökbuget Nicola; Atta Johannes; Brück Patrick; Rieder Harald; Schoch Claudia; Leimer Lothar; Schwerdtfeger Rainer; Ehninger Gerhard; Lipp Thomas; Perz Jolanta; Stelljes Matthias; Gschaidmeier Harald; Hoelzer Dieter; Ottmann Oliver G
Early prediction of response in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib.
Blood 2004;103(4):1495-8.
2004: Rummel Mathias J; de Vos Sven; Hoelzer Dieter; Koeffler H Phillip; Hofmann Wolf-K
Altered apoptosis pathways in mantle cell lymphoma.
Leukemia & lymphoma 2004;45(1):49-54.
2004: Bartolovic Kerol; Balabanov Stefan; Hartmann Ulrike; Komor Martina; Boehmler Andreas M; Bühring Hans-Jörg; Möhle Robert; Hoelzer Dieter; Kanz Lothar; Hofmann Wolf-Karsten; Brümmendorf Tim H
Inhibitory effect of imatinib on normal progenitor cells in vitro.
Blood 2004;103(2):523-9.
2004: Boehrer Simone; Nowak Daniel; Schaaf Simone; Bergmann Marion; Brieger Angela; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart; Chow Kai Uwe
In malignant myeloid cells expression of Daxx downregulates expression of p53 and of the inhibitors of apoptosis proteins.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(6):513-8.
2004: Gökbuget Nicola; Bassan Renato; Dekker Adriaan; Dombret Hervé; Foà Robin; Ifrah Norbert; Kovacsovics Tibor; Labar Boris; Mandelli Franco; Meloni Giovanna; Ribera Joseph Maria; Smedmyr Bengt; Vernant Jean-Paul; Walewski Jan; Willemze Roelof; Hoelzer Dieter;
Developing a European network for adult ALL.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5 Suppl 3():S46-52.
2004: Gökbuget N; Raff R; Brügge-Mann M; Flohr T; Scheuring U; Pfeifer H; Bartram C R; Kneba M; Hoelzer D
Risk/MRD adapted GMALL trials in adult ALL.
Annals of hematology 2004;83 Suppl 1():S129-31.
2004: Hofmann Wolf-Karsten; Lübbert Michael; Hoelzer Dieter; Phillip Koeffler H
Myelodysplastic syndromes.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(1):1-8.
2003: Rosen O; Müller H J; Gökbuget N; Langer W; Peter N; Schwartz S; Hähling D; Hartmann F; Ittel T H; Mück R; Rothmann F; Arnold R; Boos J; Hoelzer D
Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot study.
British journal of haematology 2003;123(5):836-41.
2003: Wassmann B; Gökbuget N; Scheuring U J; Binckebanck A; Reutzel R; Gschaidmeier H; Hoelzer D; Ottmann O G;
A randomized multicenter open label phase II study to determine the safety and efficacy of induction therapy with imatinib (Glivec, formerly STI571) in comparison with standard induction chemotherapy in elderly (>55 years) patients with Philadelphia chromosome-positive (Ph+/BCR-ABL+) acute lymphoblastic leukemia (ALL) (CSTI571ADE 10).
Annals of hematology 2003;82(11):716-20.
2003: Mahlknecht U; Hoelzer D
[Epigenetic regulators as novel therapeutic targets in hematology/oncology]
Deutsche medizinische Wochenschrift (1946) 2003;128(46):2423-6.
2003: Rieder Harald; Bachmann Ina; Busch Sylke; Schwartz Stefan; Reckzeh Barbara; Hoelzer Dieter
Cell lineage assignment of cytogenetic findings in acute lymphoblastic leukemia using combined immunomagnetic cell separation and chromosome preparation.
Haematologica 2003;88(11):1317-20.
2003: Pfeifer Heike; Wassmann Barbara; Hofmann Wolf-Karsten; Komor Martina; Scheuring Urban; Brück Patrick; Binckebanck Anja; Schleyer Eberhard; Gökbuget Nicola; Wolff Thomas; Lübbert Michael; Leimer Lothar; Gschaidmeier Harald; Hoelzer Dieter; Ottmann Oliver G
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4674-81.
2003: Puccetti Elena; Beissert Tim; Güller Saskia; Li Jun E; Hoelzer Dieter; Ottmann Oliver G; Ruthardt Martin
Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.
Oncogene 2003;22(44):6900-8.
2003: Wassmann B; Scheuring U; Pfeifer H; Binckebanck A; Käbisch A; Lübbert M; Leimer L; Gschaidmeier H; Hoelzer D; Ottmann O G
Efficacy and safety of imatinib mesylate (Glivec) in combination with interferon-alpha (IFN-alpha) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(10):1919-24.
2003: Mahlknecht Ulrich; Chesney Jason; Hoelzer Dieter; Bucala Richard
Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2).
International journal of oncology 2003;23(4):883-91.
2003: Beissert Tim; Puccetti Elena; Bianchini Andrea; Güller Saskia; Boehrer Simone; Hoelzer Dieter; Ottmann Oliver Gerhard; Nervi Clara; Ruthardt Martin
Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571.
Blood 2003;102(8):2985-93.
2003: Scheuring U J; Pfeifer H; Wassmann B; Brück P; Gehrke B; Petershofen E K; Gschaidmeier H; Hoelzer D; Ottmann O G
Serial minimal residual disease (MRD) analysis as a predictor of response duration in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) during imatinib treatment.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(9):1700-6.
2003: Scheuring Urban J; Pfeifer Heike; Wassmann Barbara; Brück Patrick; Hoelzer Dieter; Ottmann Oliver G
Methodologic and biological variability of quantitative real-time polymerase chain reaction analysis of Bcr-Abl expression in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Haematologica 2003;88(9):1074-6.
2003: Chow Kai Uwe; Nowak Daniel; Boehrer Simone; Ruthardt Martin; Knau Andrea; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart
Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation.
Biochemical pharmacology 2003;66(5):711-24.
2003: Hofmann Wolf-Karsten; Komor Martina; Wassmann Barbara; Jones Letetia C; Gschaidmeier Harald; Hoelzer Dieter; Koeffler H Phillip; Ottmann Oliver G
Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia.
Blood 2003;102(2):659-61.
2003: Gökbuget Nicola; Hoelzer Dieter
Non-myeloablative conditioning before allogeneic stem cell transplantation in adult acute lymphoblastic leukemia.
Haematologica 2003;88(5):484-6.
2003: Wassmann B; Scheuring U; Thiede C; Pfeifer H; Bornhäuser M; Griesinger F; Hochhaus A; Schleyer E; Gschaidmeier H; Hoelzer D; Ottmann O G
Stable molecular remission induced by imatinib mesylate (STI571) in a patient with CML lymphoid blast crisis relapsing after allogeneic stem cell transplantation.
Bone marrow transplantation 2003;31(7):611-4.
2003: Kim Soo-Zin; Zollner Thomas M; Schui Daniela K; Chow Kai U; Sterry Wolfram; Kriener Susanne; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart
CD4+ CD56+ neoplasia: clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis X.
Leukemia & lymphoma 2003;44(2):281-9.
2003: Klein Stefan A; Karsten Susanne; Rüster Brigitte; Klebba Christian; Pape Martine; Ottmann Oliver G; Hoelzer Dieter; Roth Willi K
Comparison of TaqMan real-time PCR and p24 Elisa for quantification of in vitro HIV-1 replication.
Journal of virological methods 2003;107(2):169-75.
2003: Chow Kai U; Boehrer Simone; Napieralski Simone; Nowak Daniel; Knau Andrea; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart
In AML cell lines Ara-C combined with purine analogues is able to exert synergistic as well as antagonistic effects on proliferation, apoptosis and disruption of mitochondrial membrane potential.
Leukemia & lymphoma 2003;44(1):165-73.
2003: Scheuring Urban J; Pfeifer Heike; Wassmann Barbara; Bruck Patrick; Atta Johannes; Petershofen Eduard K; Gehrke Brigitte; Gschaidmeier Harald; Hoelzer Dieter; Ottmann Oliver G
Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl-positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571).
Blood 2003;101(1):85-90.
2002: Hoelzer Dieter; Gökbuget Nicola
Treatment of lymphoblastic lymphoma in adults.
Best practice & research. Clinical haematology 2002;15(4):713-28.
2002: Gökbuget Nicola; Kneba Michael; Raff Thorsten; Bruggemann Monika; Scheuring Urban; Reutzel Regina; Hoelzer Dieter
Risk-adapted treatment according to minimal residual disease in adult ALL.
Best practice & research. Clinical haematology 2002;15(4):639-52.
2002: Boehrer Simone; Schui Daniela K; Chow Kai U; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart
Cytotoxic activity of T- and NK-cell lymphoma cells is not dependent on a mature cytotoxic phenotype.
Leukemia & lymphoma 2002;43(12):2363-8.
2002: Grundmann-Kollmann Marcella; Martin Hans; Ludwig Ralf; Klein Stefan; Boehncke Wolf-Henning; Hoelzer Dieter; Kaufmann Roland; Podda Maurizio
Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease.
Transplantation 2002;74(11):1631-4.
2002: Assmus Birgit; Schächinger Volker; Teupe Claudius; Britten Martina; Lehmann Ralf; Döbert Natascha; Grünwald Frank; Aicher Alexandra; Urbich Carmen; Martin Hans; Hoelzer Dieter; Dimmeler Stefanie; Zeiher Andreas M
Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI).
Circulation 2002;106(24):3009-17.
2002: Puccetti Elena; Obradovic Darja; Beissert Tim; Bianchini Andrea; Washburn Birgit; Chiaradonna Ferdinando; Boehrer Simone; Hoelzer Dieter; Ottmann Oliver Gerhard; Pelicci Pier Giuseppe; Nervi Clara; Ruthardt Martin
AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.
Cancer research 2002;62(23):7050-8.
2002: Arnold R; Massenkeil G; Bornhäuser M; Ehninger G; Beelen D W; Fauser A A; Hegenbart U; Hertenstein B; Ho A D; Knauf W; Kolb H J; Kolbe K; Sayer H G; Schwerdtfeger R; Wandt H; Hoelzer D
Nonmyeloablative stem cell transplantation in adults with high-risk ALL may be effective in early but not in advanced disease.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(12):2423-8.
2002: Wassmann B; Pfeifer H; Scheuring U; Klein S A; Gökbuget N; Binckebanck A; Martin H; Gschaidmeier H; Hoelzer D; Ottmann O G
Therapy with imatinib mesylate (Glivec) preceding allogeneic stem cell transplantation (SCT) in relapsed or refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL).
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(12):2358-65.
2002: Möller B; Nguyen T T; Kessler U; Kaltwasser J P; Hoelzer D; Ottmann O G
Interleukin-10 expression: is there a neglected contribution of CD8+ T cells in rheumatoid arthritis joints?
Clinical and experimental rheumatology 2002;20(6):813-22.
2002: Hofmann Wolf-K; de Vos Sven; Komor Martina; Hoelzer Dieter; Wachsman William; Koeffler H Phillip
Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow.
Blood 2002;100(10):3553-60.
2002: Hoelzer D; Arnold R; Bartram C R; Böhme A; Freund M; Ganser A; Kneba M; Lipp T; Ludwig W D; Maschmeyer G; Rieder H; Thiel E; Messerer D; Weiss A; Gökbuget N
[Acute lymphatic leukemia in the adult. Diagnosis, risk groups and therapy]
Der Internist 2002;43(10):1212-6, 1219-22, 1224-7.
2002: Hoelzer Dieter; Gökbuget Nicola; Ottmann Oliver G
Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Seminars in hematology 2002;39(4 Suppl 3):32-7.
2002: Hofmann W K; Seipelt G; Langenhan S; Reutzel R; Schott D; Schoeffski O; Illiger H J; Hartmann F; Balleisen L; Franke A; Fiedler F; Huber C; Rasche H; Bergmann L; Ganser A; Pott C; Pasold R; Rudolph C; Ottmann O G; Gökbuget N; Hoelzer D
Prospective randomized trial to evaluate two delayed granulocyte colony stimulating factor administration schedules after high-dose cytarabine therapy in adult patients with acute lymphoblastic leukemia.
Annals of hematology 2002;81(10):570-4.
2002: Bug G; Rossmanith T; Henschler R; Kunz-Schughart L A; Schröder B; Kampfmann M; Kreutz M; Hoelzer D; Ottmann O G
Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells.
Journal of leukocyte biology 2002;72(4):837-45.
2002: Boehrer Simone; Chow Kai U; Ruthardt Martin; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart
Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells.
Leukemia & lymphoma 2002;43(9):1737-41.
2002: Möller B; Kukoc-Zivojnov N; Koyama N; Grapenthin S; Kessler U; Klein S A; Kalina U; Kaltwasser J P; Hoelzer D; Ottmann O G
Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(9):457-63.
2002: Kalina Uwe; Koyama Noriko; Hosoda Tomoko; Nuernberger Heike; Sato Kazuto; Hoelzer Dieter; Herweck Frank; Manigold Tobias; Singer Manfred V; Rossol Siegbert; Böcker Ulrich
Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region.
European journal of immunology 2002;32(9):2635-43.
2002: Ottmann Oliver G; Druker Brian J; Sawyers Charles L; Goldman John M; Reiffers Jose; Silver Richard T; Tura Sante; Fischer Thomas; Deininger Michael W; Schiffer Charles A; Baccarani Michele; Gratwohl Alois; Hochhaus Andreas; Hoelzer Dieter; Fernandes-Reese Sofia; Gathmann Insa; Capdeville Renaud; O'Brien Stephen G
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias.
Blood 2002;100(6):1965-71.
2002: Rummel M J; Chow K U; Karakas T; Jäger E; Mezger J; von Grünhagen U; Schalk K P; Burkhard O; Hansmann M L; Ritzel H; Bergmann L; Hoelzer D; Mitrou P S
Reduced-dose cladribine (2-CdA) plus mitoxantrone is effective in the treatment of mantle-cell and low-grade non-Hodgkin's lymphoma.
European journal of cancer (Oxford, England : 1990) 2002;38(13):1739-46.
2002: Ott Marion-Gabriele; Merget-Millitzer Heike; Ottmann Oliver Gerhard; Martin Hans; Brüggenolte Nicole; Bialek Heike; Seger Reinhard; Hossle Johann Peter; Hoelzer Dieter; Grez Manuel
Mobilization and transduction of CD34(+) peripheral blood stem cells in patients with X-linked chronic granulomatous disease.
Journal of hematotherapy & stem cell research 2002;11(4):683-94.
2002: Weidmann E; Kim S-Z; Rost A; Schuppert H; Seipelt G; Hoelzer D; Mitrou P S
Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(8):1285-9.
2002: Rummel Mathias J; Mitrou Paris S; Hoelzer Dieter
Bendamustine in the treatment of non-Hodgkin's lymphoma: results and future perspectives.
Seminars in oncology 2002;29(4 Suppl 13):27-32.
2002: Rummel Mathias J; Chow Kai U; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart
In vitro studies with bendamustine: enhanced activity in combination with rituximab.
Seminars in oncology 2002;29(4 Suppl 13):12-4.
2002: Dobmeyer Thomas S; Dobmeyer Rita; Wesch Daniela; Helm Eilke B; Hoelzer Dieter; Kabelitz Dieter
Reciprocal alterations of Th1/Th2 function in gammadelta T-cell subsets of human immunodeficiency virus-1-infected patients.
British journal of haematology 2002;118(1):282-8.
2002: Gökbuget Nicola; Hoelzer Dieter
Recent approaches in acute lymphoblastic leukemia in adults.
Reviews in clinical and experimental hematology 2002;6(2):114-41; discussion 200-2.
2002: Möller Burkhard; Kukoc-Zivojnov Natasa; Okamgba Stella; Kessler Uta; Puccetti Elena; Ottmann Oliver G; Kaltwasser Joachim P; Hoelzer Dieter; Ruthardt Martin
Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.
Rheumatology international 2002;22(2):60-7.
2002: Hoelzer Dieter; Gökbuget Nicola; Digel Werner; Faak Thomas; Kneba Michael; Reutzel Regina; Romejko-Jarosinska Joanna; Zwolinski Jacek; Walewski Jan
Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia.
Blood 2002;99(12):4379-85.
2002: Karakas T; Miething C C; Maurer U; Weidmann E; Ackermann H; Hoelzer D; Bergmann L
The coexpression of the apoptosis-related genes bcl-2 and wt1 in predicting survival in adult acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(5):846-54.
2002: Schroeder Katharina; Koschmieder Steffen; Ottmann Oliver G; Hoelzer Dieter; Hauser Hansjörg; Mueller Peter P
Coordination of cell growth in cocultures by a genetic proliferation control system.
Biotechnology and bioengineering 2002;78(3):346-52.
2002: Gökbuget Nicola; Hoelzer Dieter
The role of high-dose cytarabine in induction therapy for adult ALL.
Leukemia research 2002;26(5):473-6.
2002: Mahlknecht Ulrich; Schnittger Susanne; Will Jutta; Cicek Nurten; Hoelzer Dieter
Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9).
Biochemical and biophysical research communications 2002;293(1):182-91.
2002: Koyama Noriko; Koschmieder Steffen; Tyagi Sandhya; Nürnberger Heike; Wagner Sandra; Böcker U; Hoelzer Dieter; Gerhard Ottmann Oliver; Kalina Uwe
Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells.
Biochemical and biophysical research communications 2002;292(4):937-43.
2002: Hofmann Wolf K; Takeuchi Seisho; Frantzen Malka A; Hoelzer Dieter; Koeffler H Phillip
Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.
Experimental hematology 2002;30(4):318-23.
2002: Schui Daniela K; Singh Lisa; Schneider Bernd; Knau Andrea; Hoelzer Dieter; Weidmann Eckhart
Inhibiting effects on the induction of cytotoxic T lymphocytes by dendritic cells pulsed with lysates from acute myeloid leukemia blasts.
Leukemia research 2002;26(4):383-9.
2002: Koschmieder Steffen; Fauth Florian; Kriener Susanne; Hoelzer Dieter; Seipelt Gernot
Effective treatment of simultaneous small cell lung cancer and B-cell lymphoma.
Leukemia & lymphoma 2002;43(3):645-7.
2002: Boehrer Simone; Chow Kai U; Beske Florian; Kukoc-Zivojnov Natasa; Puccetti Elena; Ruthardt Martin; Baum Christine; Rangnekar Vivek M; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckhart
In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation.
Cancer research 2002;62(6):1768-75.
2002: Klein Stefan A; Hermann Stella; Dietrich Johann Wolfgang; Hoelzer Dieter; Martin Hans
Transplantation-related toxicity and acute intestinal graft-versus-host disease after conditioning regimens intensified with Rhenium 188-labeled anti-CD66 monoclonal antibodies.
Blood 2002;99(6):2270-1.
2002: Hofmann Wolf-K; Jones Letetia C; Lemp Nathan A; de Vos Sven; Gschaidmeier Harald; Hoelzer Dieter; Ottmann Oliver G; Koeffler H Phillip
Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.
Blood 2002;99(5):1860-2.
2002: Gleissner Beate; Gökbuget Nicola; Bartram Claus R; Janssen Bart; Rieder Harald; Janssen Johannes W G; Fonatsch Christa; Heyll Axel; Voliotis Dimitris; Beck Joachim; Lipp Thomas; Munzert Gerd; Maurer Jürgen; Hoelzer Dieter; Thiel Eckhard;
Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis.
Blood 2002;99(5):1536-43.
2002: Chow Kai U; Boehrer Simone; Bojunga Joerg; Stieler Manuela; Rummel Mathias J; Fauth Florian; Schneider Bernd; Martin Hans; Hoelzer Dieter; Weidmann Eckhart; Mitrou Paris S
Induction of apoptosis by cladribine (2-CdA), gemcitabine and other chemotherapeutic drugs on CD34+/CD38+ and CD34+/CD38- hematopoietic progenitor cells: selective effects of doxorubicin and 2-CdA with protection of immature cells.
Leukemia & lymphoma 2002;43(2):377-84.
2002: Hofmann Wolf K; de Vos Sven; Elashoff David; Gschaidmeier Harald; Hoelzer Dieter; Koeffler H Phillip; Ottmann Oliver G
Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study.
Lancet 2002;359(9305):481-6.
2002: Seipelt Gernot; Germing Ulrich; Koschmieder Steffen; Böhme Angelika; Aul Carlo; Hoelzer Dieter
Secondary acute myeloid leukaemia with monosomy 7 in identical adult twins.
British journal of haematology 2002;116(2):338-40.
2002: Gombart Adrian F; Hofmann Wolf-K; Kawano Seiji; Takeuchi Seisho; Krug Utz; Kwok Scott H; Larsen Renee J; Asou Hiroya; Miller Carl W; Hoelzer Dieter; Koeffler H Phillip
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.
Blood 2002;99(4):1332-40.
2002: Ottmann Oliver G; Wassmann Barbara; Hoelzer Dieter
[Therapy of Philadelphia chromosome positive acute lymphatic leukemia (Ph+ ALL) with an inhibitor of abl-tyrosine kinase (Glivec)]
Medizinische Klinik (Munich, Germany : 1983) 2002;97 Suppl 1():16-21.
2002: Chow Kai U; Sommerlad Wolf Daniel; Boehrer Simone; Schneider Bernd; Seipelt Gernot; Rummel Mathias Johannes; Hoelzer Dieter; Mitrou Paris S; Weidmann Eckart
Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.
Haematologica 2002;87(1):33-43.
2002: Ottmann O G; Wassmann B; Hoelzer D
Imatinib for relapsed BCR/ABL positive leukemias.
Annals of hematology 2002;81 Suppl 2():S36-7.
2002: Hoelzer Dieter; Gökbuget Nicola; Ottmann Oliver; Pui Ching-Hon; Relling Mary V; Appelbaum Frederick R; van Dongen Jacques J M; Szczepanski Tomasz
Acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2002;():162-92.
2002: Ottmann Oliver G; Hoelzer Dieter
The ABL tyrosine kinase inhibitor STI571 (Glivec) in Philadelphia positive acute lymphoblastic leukemia - promises, pitfalls and possibilities.
The hematology journal : the official journal of the European Haematology Association / EHA 2002;3(1):2-6.
2002: Möller Burkhard; Kessler Uta; Rehart Stefan; Kalina Uwe; Ottmann Oliver G; Kaltwasser Joachim Peter; Hoelzer Dieter; Kukoc-Zivojnov Natasa
Expression of interleukin-18 receptor in fibroblast-like synoviocytes.
Arthritis research 2002;4(2):139-44.
2001: Klein S A; Martin H; Schreiber-Dietrich D; Hermann S; Caspary W F; Hoelzer D; Dietrich C F
A new approach to evaluating intestinal acute graft-versus-host disease by transabdominal sonography and colour Doppler imaging.
British journal of haematology 2001;115(4):929-34.
2001: Gleissner B; Rieder H; Thiel E; Fonatsch C; Janssen L A; Heinze B; Janssen J W; Schoch C; Goekbuget N; Maurer J; Hoelzer D; Bartram C R
Prospective BCR-ABL analysis by polymerase chain reaction (RT-PCR) in adult acute B-lineage lymphoblastic leukemia: reliability of RT-nested-PCR and comparison to cytogenetic data.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(12):1834-40.
2001: Wassmann B; Klein S A; Scheuring U; Pfeifer H; Martin H; Gschaidmeier H; Hoelzer D; Ottmann O G
Hematologic and cytogenetic remission by STI571 (Glivec) in a patient relapsing with accelerated phase CML after second allogeneic stem cell transplantation.
Bone marrow transplantation 2001;28(7):721-4.
2001: Hofmann W K; Takeuchi S; Xie D; Miller C W; Hoelzer D; Koeffler H P
Frequent loss of heterozygosity in the region of D1S450 at 1p36.2 in myelodysplastic syndromes.
Leukemia research 2001;25(10):855-8.
2001: Koschmieder S; Hofmann W K; Kunert J; Wagner S; Ballas K; Seipelt G; Hoelzer D; Ottmann O G; Kalina U
TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(6):942-9.
2001: Chow K U; Boehrer S; Geduldig K; Krapohl A; Hoelzer D; Mitrou P S; Weidmann E
In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine.
Haematologica 2001;86(5):485-93.
2001: Hermann S; Klein S A; Jacobi V; Thalhammer A; Bialleck H; Duchscherer M; Wassmann B; Hoelzer D; Martin H
Older patients with high-risk fungal infections can be successfully allografted using non-myeloablative conditioning in combination with intensified supportive care regimens.
British journal of haematology 2001;113(2):446-54.
2001: Kalina U; Koschmieder S; Hofmann W K; Wagner S; Kauschat D; Hoelzer D; Ottmann O G
Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.
Experimental hematology 2001;29(5):602-8.
2001: Weidmann E; Boehrer S; Chow K U; Engels K; Harder L; Hinz T; Janssen O; Kriener S; Rummel M J; Siebert R; Kabelitz D; Hansmann M L; Hoelzer D; Mitrou P S;
Treatment of aggressive, or progressing indolent peripheral T- and NK-cell neoplasias by combination of fludarabine, cyclophosphamide and doxorubicine.
Onkologie 2001;24(2):162-4.
2001: Hofmann W K; Miller C W; Tsukasaki K; Tavor S; Ikezoe T; Hoelzer D; Takeuchi S; Koeffler H P
Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias.
Leukemia research 2001;25(4):333-8.
2001: Chow K U; Mitrou P S; Geduldig K; Helm E B; Hoelzer D; Brodt H R
Changing incidence and survival in patients with aids-related non-Hodgkin's lymphomas in the era of highly active antiretroviral therapy (HAART).
Leukemia & lymphoma 2001;41(1-2):105-16.
2001: Seipelt G; Böhme A; Koschmieder S; Hoelzer D
Effective treatment with rituximab in a patient with refractory prolymphocytoid transformed B-chronic lymphocytic leukemia and Evans syndrome.
Annals of hematology 2001;80(3):170-3.
2001: Möller B; Kukoc-Zivojnov N; Kessler U; Rehart S; Kaltwasser J P; Hoelzer D; Kalina U; Ottmann O G
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis.
Rheumatology (Oxford, England) 2001;40(3):302-9.
2001: Fauth F; Weidmann E; Martin H; Schneider B; Sonnhoff S; Hoelzer D
AC133 expression on acute myeloid leukemia blasts: correlation to FAB and to CD34 expression and possible implications for peripheral blood progenitor cell purging in AML.
Leukemia research 2001;25(3):191-6.
2001: Koschmieder S; Bug G; Schröder B; Rossmanith T; Hofmann W K; Kalina U; Hoelzer D; Ottmann O G
Murine M2-10B4 and SL/SL cell lines differentially affect the balance between CD34+ cell expansion and maturation.
International journal of hematology 2001;73(1):71-7.
2001: Boehrer S; Hinz T; Schui D; Harder S; Chow K U; Schneider B; Hoelzer D; Mitrou P S; Weidmann E
T-large granular lymphocyte leukaemia with natural killer cell-like cytotoxicity and expression of two different alpha- and beta-T-cell receptor chains.
British journal of haematology 2001;112(1):201-3.
2001: Puccetti E; Sennewald B; Fosca-Ferrara F; Boehrer S; Bianchini A; Hoelzer D; Ottmann O G; Nervi C; Ruthardt M
Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(6):385-92.
2001: Rossmanith T; Schröder B; Bug G; Müller P; Klenner T; Knaus R; Hoelzer D; Ottmann O G
Interleukin 3 improves the ex vivo expansion of primitive human cord blood progenitor cells and maintains the engraftment potential of scid repopulating cells.
Stem cells (Dayton, Ohio) 2001;19(4):313-20.
2001: Boehrer S; Chow K U; Puccetti E; Ruthardt M; Godzisard S; Krapohl A; Schneider B; Hoelzer D; Mitrou P S; Rangnekar V M; Weidmann E
Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(2):103-7.
2000: Gökbuget N; Hoelzer D; Arnold R; Böhme A; Bartram C R; Freund M; Ganser A; Kneba M; Langer W; Lipp T; Ludwig W D; Maschmeyer G; Rieder H; Thiel E; Weiss A; Messerer D
Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL).
Hematology/oncology clinics of North America 2000;14(6):1307-25, ix.
2000: Kalina U; Ballas K; Koyama N; Kauschat D; Miething C; Arnemann J; Martin H; Hoelzer D; Ottmann O G
Genomic organization and regulation of the human interleukin-18 gene.
Scandinavian journal of immunology 2000;52(6):525-30.
2000: Hoelzer D; Gökbuget N
New approaches to acute lymphoblastic leukemia in adults: where do we go?
Seminars in oncology 2000;27(5):540-59.
2000: Kalina U; Hofmann W K; Koschmieder S; Wagner S; Kauschat D; Hoelzer D; Ottmann O G
Alteration of c-mpl-mediated signal transduction in CD34(+) cells from patients with myelodysplastic syndromes.
Experimental hematology 2000;28(10):1158-63.
2000: Weidmann E; Hinz T; Klein S; Schui D K; Harder S; Kriener S; Kabelitz D; Hoelzer D; Mitrou P S
Cytotoxic hepatosplenic gammadelta T-cell lymphoma following acute myeloid leukemia bearing two distinct gamma chains of the T-cell receptor. Biologic and clinical features.
Haematologica 2000;85(10):1024-31.
2000: Mahlknecht U; Schnittger S; Ottmann O G; Schoch C; Mosebach M; Hiddemann W; Hoelzer D
Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5).
Biochimica et biophysica acta 2000;1493(3):342-8.
2000: Chow K U; Ries J; Weidmann E; Pourebrahim F; Napieralski S; Stieler M; Boehrer S; Rummel M J; Stein J; Hoelzer D; Mitrou P S
Induction of apoptosis using 2',2' difluorodeoxycytidine (gemcitabine) in combination with antimetabolites or anthracyclines on malignant lymphatic and myeloid cells. Antagonism or synergism depends on incubation schedule and origin of neoplastic cells.
Annals of hematology 2000;79(9):485-92.
2000: Hofmann W K; Kell W J; Fenaux P; Castaigne S; Ganser A; Chomienne C; Burnett R; Kowal C; Hoelzer D; Burnett A K
Oral 9-cis retinoic acid (Alitretinoin) in the treatment of myelodysplastic syndromes: results from a pilot study.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(9):1583-8.
2000: Kalina U; Kauschat D; Koyama N; Nuernberger H; Ballas K; Koschmieder S; Bug G; Hofmann W K; Hoelzer D; Ottmann O G
IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1307-13.
2000: Vogl T J; Hinrichs T; Jacobi V; Böhme A; Hoelzer D
[Computed tomographic appearance of pulmonary mucormycosis]
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 2000;172(7):604-8.
2000: Puccetti E; Güller S; Orleth A; Brüggenolte N; Hoelzer D; Ottmann O G; Ruthardt M
BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity.
Cancer research 2000;60(13):3409-13.
2000: Gottschalk R; Seidl C; Schilling S; Braner A; Seifried E; Hoelzer D; Kaltwasser J P
Iron-overload and genotypic expression of HFE mutations H63D/C282Y and transferrin receptor Hin6I and BanI polymorphism in german patients with hereditary haemochromatosis.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2000;27(3):129-34.
2000: Hofmann W K; Kalina U; Koschmieder S; Seipelt G; Hoelzer D; Ottmann O G
Defective megakaryocytic development in myelodysplastic syndromes.
Leukemia & lymphoma 2000;38(1-2):13-9.
2000: Grez M; Becker S; Saulnier S; Knöss H; Ott M G; Maurer A; Dinauer M C; Hoelzer D; Seger R; Hossle J P
Gene therapy of chronic granulomatous disease.
Bone marrow transplantation 2000;25 Suppl 2():S99-104.
2000: Hofmann W K; Seipelt G; Ottmann O G; Kalina U; Koschmieder S; Brücher J; Frickhofen N; Klausmann M; Mitrou P S; Hoelzer D
Effect of treatment with amifostine used as a single agent in patients with refractory anemia on clinical outcome and serum tumor necrosis factor alpha levels.
Annals of hematology 2000;79(5):255-8.
2000: Xie D; Hofmann W K; Mori N; Miller C W; Hoelzer D; Koeffler H P
Allelotype analysis of the myelodysplastic syndrome.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2000;14(5):805-10.
2000: Seipelt G; Ottmann O G; Hoelzer D
Cytokine therapy for myelodysplastic syndrome.
Current opinion in hematology 2000;7(3):156-60.
2000: Fauth F; Martin H; Sonnhoff S; Bialleck H; Wiesneth M; Mihanovic B; Hoelzer D
Purging of G-CSF-mobilized peripheral autografts in acute leukemia with mafosfamide and amifostine to protect normal progenitor cells.
Bone marrow transplantation 2000;25(8):831-6.
2000: Wassmann B; Seipelt G; Länger F; Rummel M; Böhme A; Hansmann M L; Hoelzer D
[Pancytopenia, hepatosplenomegaly and fever in a 49-year old patient]
Der Internist 2000;41(3):304-8.
2000: Klein S A; Klebba C; Kauschat D; Pape M; Ozmen L; Hoelzer D; Ottmann O G; Kalina U
Interleukin-18 stimulates HIV-1 replication in a T-cell line.
European cytokine network 2000;11(1):47-52.
2000: Gottschalk R; Wigand R; Dietrich C F; Oremek G; Liebisch F; Hoelzer D; Kaltwasser J P
Total iron-binding capacity and serum transferrin determination under the influence of several clinical conditions.
Clinica chimica acta; international journal of clinical chemistry 2000;293(1-2):127-38.
2000: Klebba C; Ottmann O G; Scherr M; Pape M; Engels J W; Grez M; Hoelzer D; Klein S A
Retrovirally expressed anti-HIV ribozymes confer a selective survival advantage on CD4+ T cells in vitro.
Gene therapy 2000;7(5):408-16.
2000: Chow K U; Rummel M J; Weidmann E; Ries J; Jantschke P; Boehrer S; Pourebrahim F; Napieralski S; Stein J; Martin H; Hoelzer D; Mitrou P S
Induction of apoptosis by 2-chloro-2'deoxyadenosine (2-CdA) alone and in combination with other cytotoxic drugs: synergistic effects on normal and neoplastic lymphocytes by addition of doxorubicin and mitoxantrone.
Leukemia & lymphoma 2000;36(5-6):559-67.
2000: Ganser A; Heil G; Seipelt G; Hofmann W; Fischer J T; Langer W; Brockhaus W; Kolbe K; Ittel T H; Brack N; Fuhr H G; Knuth P; Höffken K; Bergmann L; Hoelzer D
Intensive chemotherapy with idarubicin, ara-C, etoposide, and m-AMSA followed by immunotherapy with interleukin-2 for myelodysplastic syndromes and high-risk Acute Myeloid Leukemia (AML).
Annals of hematology 2000;79(1):30-5.
2000: Atta J; Fauth F; Keyser M; Petershofen E; Weber C; Lippok G; Hoelzer D; Martin H
Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction.
Bone marrow transplantation 2000;25(1):97-104.
1999: Archimbaud E; Ottmann O G; Yin J A; Lechner K; Dombret H; Sanz M A; Heil G; Fenaux P; Brugger W; Barge A; O'Brien-Ewen C; Matcham J; Hoelzer D
A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia.
Blood 1999;94(11):3694-701.
1999: Rummel M J; Chow K U; Jäger E; Leimer L; Hossfeld D K; Bergmann L; Peters H D; Hansmann M L; Meyer A; Hoelzer D; Mitrou P S
Intermittent 2-hour-infusion of cladribine as first-line therapy or in first relapse of progressive advanced low-grade and mantle cell lymphomas.
Leukemia & lymphoma 1999;35(1-2):129-38.
1999: Wiedmann E; Baican B; Hertel A; Baum R P; Chow K U; Knupp B; Adams S; Hör G; Hoelzer D; Mitrou P S
Positron emission tomography (PET) for staging and evaluation of response to treatment in patients with Hodgkin's disease.
Leukemia & lymphoma 1999;34(5-6):545-51.
1999: Sternsdorf T; Puccetti E; Jensen K; Hoelzer D; Will H; Ottmann O G; Ruthardt M
PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Molecular and cellular biology 1999;19(7):5170-8.
1999: Krauter J; Ganser A; Bergmann L; Raghavachar A; Hoelzer D; Lübbert M; Schlimok G; Arnold R; Kirchner H; Port M; Heil G
Association between structural and numerical chromosomal aberrations in acute myeloblastic leukemia: a study by RT-PCR and FISH in 447 patients with de-novo AML.
Annals of hematology 1999;78(6):265-9.
1999: Klein S A; Ottmann O G; Ballas K; Dobmeyer T S; Pape M; Weidmann E; Hoelzer D; Kalina U
Quantification of human interleukin 18 mRNA expression by competitive reverse transcriptase polymerase chain reaction.
Cytokine 1999;11(6):451-8.
1999: Hofmann W K; Kalina U; Seipelt G; Hoffmann K; Wagner S; Hoelzer D; Ottmann O G
Megakaryocytic growth in patients with refractory anemia is suppressed by treatment with interferon alpha.
European journal of haematology 1999;62(5):336-40.
1999: Hofmann W K; Ottmann O G; Hoelzer D
Memorial lecture. Megakaryocytic growth factors: is there a new approach for management of thrombocytopenia in patients with malignancies?
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13 Suppl 1():S14-8.
1999: Hofmann W K; Ganser A; Seipelt G; Ottmann O G; Zander C; Geissler G; Hoffmann K; Höffken K; Fischer J T; Isele G; Hoelzer D
Treatment of patients with low-risk myelodysplastic syndromes using a combination of all-trans retinoic acid, interferon alpha, and granulocyte colony-stimulating factor.
Annals of hematology 1999;78(3):125-30.
1999: Gökbuget N; Arnold R; Büchner T; Freund M; Gassmann W; Heil G; Hiddemann W; Löffler H; Lipp T; Ludwig W D; Maschmeyer G; Thiel E; Messerer D; Hoelzer D
[Treatment of adult acute lymphoblastic leukemia]
Praxis 1999;88(10):407-20.
1999: Hofmann W K; Kalina U; Wagner S; Seipelt G; Ries C; Hoelzer D; Ottmann O G
Characterization of defective megakaryocytic development in patients with myelodysplastic syndromes.
Experimental hematology 1999;27(3):395-400.
1999: Rummel M J; Käfer G; Pfreundschuh M; Jäger E; Reinhardt U; Mitrou P S; Hoelzer D; Bergmann L
Fludarabine and epirubicin in the treatment of chronic lymphocytic leukaemia: a German multicenter phase II study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(2):183-8.
1999: Rummel M J; Chow K U; Jäger E; Hossfeld D K; Bergmann L; Peters H D; Hansmann M L; Meyer A; Hoelzer D; Mitrou P S
Treatment of mantle-cell lymphomas with intermittent two-hour infusion of cladribine as first-line therapy or in first relapse.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(1):115-7.
1999: Hofmann W K; Ottmann O G; Hoelzer D
Megakaryocytic growth factors: is there a new approach for management of thrombocytopenia in patients with malignancies?
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1999;13(1):14-8.
1998: Ottmann O G; Hoelzer D
Growth factors in the treatment of acute lymphoblastic leukemia.
Leukemia research 1998;22(12):1171-8.
1998: Böhme A; Wolter M; Hoelzer D
L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia.
Annals of hematology 1998;77(5):235-8.
1998: Schilz A J; Brouns G; Knöss H; Ottmann O G; Hoelzer D; Fauser A A; Thrasher A J; Grez M
High efficiency gene transfer to human hematopoietic SCID-repopulating cells under serum-free conditions.
Blood 1998;92(9):3163-71.
1998: Krauter J; Peter W; Pascheberg U; Heinze B; Bergmann L; Hoelzer D; Lübbert M; Schlimok G; Arnold R; Kirchner H; Port M; Ganser A; Heil G
Detection of karyotypic aberrations in acute myeloblastic leukaemia: a prospective comparison between PCR/FISH and standard cytogenetics in 140 patients with de novo AML.
British journal of haematology 1998;103(1):72-8.
1998: Böhme A; Shah P M; Stille W; Hoelzer D
[Antibiotic therapy in leukopenia]
Praxis 1998;87(36):1120-5.
1998: Rieder H; Bonwetsch C; Janssen L A; Maurer J; Janssen J W; Schwartz S; Ludwig W D; Gassmann W; Bartram C R; Thiel E; Löffler H; Gökbuget N; Hoelzer D; Fonatsch C
High rate of chromosome abnormalities detected by fluorescence in situ hybridization using BCR and ABL probes in adult acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(9):1473-81.
1998: Ludwig W D; Rieder H; Bartram C R; Heinze B; Schwartz S; Gassmann W; Löffler H; Hossfeld D; Heil G; Handt S; Heyll A; Diedrich H; Fischer K; Weiss A; Völkers B; Aydemir U; Fonatsch C; Gökbuget N; Thiel E; Hoelzer D
Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: results of the German multicenter trials GMALL 03/87 and 04/89.
Blood 1998;92(6):1898-909.
1998: Becker S; Wasser S; Hauses M; Hossle J P; Ott M G; Dinauer M C; Ganser A; Hoelzer D; Seger R; Grez M
Correction of respiratory burst activity in X-linked chronic granulomatous cells to therapeutically relevant levels after gene transfer into bone marrow CD34+ cells.
Human gene therapy 1998;9(11):1561-70.
1998: Böhme A; Shah P M; Stille W; Hoelzer D
Piperacillin/tazobactam versus cefepime as initial empirical antimicrobial therapy in febrile neutropenic patients: a prospective randomized pilot study.
European journal of medical research 1998;3(7):324-30.
1998: Dobmeyer T S; Klein S A; Dobmeyer J M; Raffel B; Findhammer S; Hoelzer D; Helm E B; Rossol R; Kabelitz D
Differential expression of bcl-2 and susceptibility to programmed cell death in lymphocytes of HIV-1-infected individuals.
Clinical immunology and immunopathology 1998;87(3):230-9.
1998: Seipelt G; Hofmann W K; Martin H; Wassmann B; Boehme A; Ottmann O G; Hoelzer D
Comparison of toxicity and outcome in patients with acute myeloid leukemia treated with high-dose cytosine arabinoside consolidation after induction with a regimen containing idarubicin or daunorubicin.
Annals of hematology 1998;76(3-4):145-51.
1998: Gottschalk R; Seidl C; Löffler T; Seifried E; Hoelzer D; Kaltwasser J P
HFE codon 63/282 (H63D/C282Y) dimorphism in German patients with genetic hemochromatosis.
Tissue antigens 1998;51(3):270-5.
1998: Rossol R; Dobmeyer J M; Dobmeyer T S; Klein S A; Rossol S; Wesch D; Hoelzer D; Kabelitz D; Helm E B
Increase in Vdelta1+ gammadelta T cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections.
British journal of haematology 1998;100(4):728-34.
1998: Dobmeyer T S; Dobmeyer J M; Klein S A; Wesch D; Wagner S; Helm E B; Hoelzer D; Rossol R; Kabelitz D
Mechanism of gamma sigma T-cell-mediated inhibition of stem cell differentiation in vitro: possible relevance for myelosuppression in HIV-infected individuals.
Cellular immunology 1998;184(1):26-36.
1998: Karakas T; Maurer U; Weidmann E; Miething C C; Hoelzer D; Bergmann L
High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9(2):159-65.
1998: Böhme A; Shah P M; Stille W; Hoelzer D
Prospective randomized study to compare imipenem 1.5 grams per day vs. 3.0 grams per day in infections of granulocytopenic patients.
The Journal of infection 1998;36(1):35-42.
1998: Hoelzer D; Fliedner T M
A tribute to Theodor M. Fliedner.
Stem cells (Dayton, Ohio) 1998;16 Suppl 1():ix-xvii.
1997: Ottmann O G; Seipelt G; Hoelzer D
[Clinical administration of hematopoietic growth factors. When and where?]
Der Internist 1997;38(12):1160-7.
1997: Heil G; Hoelzer D; Sanz M A; Lechner K; Liu Yin J A; Papa G; Noens L; Szer J; Ganser A; O'Brien C; Matcham J; Barge A
A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia. The International Acute Myeloid Leukemia Study Group.
Blood 1997;90(12):4710-8.
1997: Maurer U; Weidmann E; Karakas T; Hoelzer D; Bergmann L
Wilms tumor gene (wt1) mRNA is equally expressed in blast cells from acute myeloid leukemia and normal CD34+ progenitors.
Blood 1997;90(10):4230-2.
1997: Gökbuget N; Hoelzer D
Vindesine in the treatment of leukaemia.
Leukemia & lymphoma 1997;26(5-6):497-506.
1997: Maurer U; Brieger J; Weidmann E; Mitrou P S; Hoelzer D; Bergmann L
The Wilms' tumor gene is expressed in a subset of CD34+ progenitors and downregulated early in the course of differentiation in vitro.
Experimental hematology 1997;25(9):945-50.
1997: Bergmann L; Miething C; Maurer U; Brieger J; Karakas T; Weidmann E; Hoelzer D
High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome.
Blood 1997;90(3):1217-25.
1997: Klein S A; Dobmeyer J M; Dobmeyer T S; Pape M; Ottmann O G; Helm E B; Hoelzer D; Rossol R
Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry.
AIDS (London, England) 1997;11(9):1111-8.
1997: Weidmann E; Brieger J; Karakas T; Maurer U; Pascheberg U; Hoelzer D; Mitrou P S; Bergmann L
Establishment and characterization of a new, factor-independent acute myeloid leukemia line designated Ei501.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(5):709-13.
1997: Gassmann W; Löffler H; Thiel E; Ludwig W D; Schwartz S; Haferlach T; Maurer J; Rieder H; Fonatsch C; Gökbuget N; Hoelzer D
Morphological and cytochemical findings in 150 cases of T-lineage acute lymphoblastic leukaemia in adults. German Multicentre ALL Study Group (GMALL).
British journal of haematology 1997;97(2):372-82.
1997: Wigand R; Gottschalk R; Falkenbach A; Matthias T; Kaltwasser J P; Hoelzer D
[Detection of dsDNA antibodies in diagnosis of systemic lupus erythematosus--comparative studies of diagnostic effectiveness of 3 ELISA methods with different antigens and a Crithidia luciliae immunofluorescence test]
Zeitschrift für Rheumatologie 1997;56(2):53-62.
1997: Kabelitz D; Hinz T; Dobmeyer T; Mentzel U; Marx S; Böhme A; Arden B; Rossol R; Hoelzer D
Clonal expansion of Vgamma3/Vdelta3-expressing gammadelta T cells in an HIV-1/2-negative patient with CD4 T-cell deficiency.
British journal of haematology 1997;96(2):266-71.
1997: Dobmeyer T S; Findhammer S; Dobmeyer J M; Klein S A; Raffel B; Hoelzer D; Helm E B; Kabelitz D; Rossol R
Ex vivo induction of apoptosis in lymphocytes is mediated by oxidative stress: role for lymphocyte loss in HIV infection.
Free radical biology & medicine 1997;22(5):775-85.
1996: Karakas T; Bergmann L; Stutte H J; Jäger E; Knuth A; Weidmann E; Mitrou P S; Hoelzer D
Peripheral T-cell lymphomas respond well to vincristine, adriamycin, cyclophosphamide, prednisone and etoposide (VACPE) and have a similar outcome as high-grade B-cell lymphomas.
Leukemia & lymphoma 1996;24(1-2):121-9.
1996: Böhme A; Just-Nübling G; Bergmann L; Shah P M; Stille W; Hoelzer D
Itraconazole for prophylaxis of systemic mycoses in neutropenic patients with haematological malignancies.
The Journal of antimicrobial chemotherapy 1996;38(6):953-61.
1996: Rieder H; Ludwig W D; Gassmann W; Maurer J; Janssen J W; Gökbuget N; Schwartz S; Thiel E; Löffler H; Bartram C R; Hoelzer D; Fonatsch C
Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia.
British journal of haematology 1996;95(4):678-91.
1996: Böhme A; Hoelzer D
Liposomal amphotericin B as early empiric antimycotic therapy of pneumonia in granulocytopenic patients.
Mycoses 1996;39(11-12):419-26.
1996: Hoelzer D; Gökbuget N; Arnold R; Büchner T; Freund M; Gassmann W; Heil G; Hiddemann W; Löffler H; Lipp T; Ludwig W D; Maschmeyer G; Thiel E; Messerer D
[Acute lymphatic leukemia of the adult. Diagnosis, risk groups and therapy]
Der Internist 1996;37(10):994-1007.
1996: Atta J; Martin H; Bruecher J; Elsner S; Wassmann B; Rode C; Russ A; Kvalheim G; Hoelzer D
Residual leukemia and immunomagnetic bead purging in patients with BCR-ABL-positive acute lymphoblastic leukemia.
Bone marrow transplantation 1996;18(3):541-8.
1996: Ganser A; Hoelzer D
Clinical use of hematopoietic growth factors in the myelodysplastic syndromes.
Seminars in hematology 1996;33(3):186-95.
1996: Hofmann W K; Ottmann O G; Ganser A; Hoelzer D
Myelodysplastic syndromes: clinical features.
Seminars in hematology 1996;33(3):177-85.
1996: Geissler R G; Rossol R; Mentzel U; Ottmann O G; Klein A S; Gute P; Helm E B; Hoelzer D; Ganser A
Gamma delta-T cell-receptor-positive lymphocytes inhibit human hematopoietic progenitor cell growth in HIV type 1-infected patients.
AIDS research and human retroviruses 1996;12(7):577-84.
1996: Ganser A; Maurer A; Contzen C; Seipelt G; Ottmann O G; Schadeck-Gressel C; Kolbe K; Haas R; Zander C; Reutzel R; Hoelzer D
Improved multilineage response of hematopoiesis in patients with myelodysplastic syndromes to a combination therapy with all-trans-retinoic acid, granulocyte colony-stimulating factor, erythropoietin and alpha-tocopherol.
Annals of hematology 1996;72(4):237-44.
1996: Klein S A; Dobmeyer J M; Dobmeyer T S; Falke D; Kabelitz D; Friese K; Helm E B; Hoelzer D; Rossol-Voth R
TNF-alpha mediated apoptosis of CD4 positive T-lymphocytes. A model of T-cell depletion in HIV infected individuals.
European journal of medical research 1996;1(5):249-58.
1996: Eder M; Hemmati P; Kalina U; Ottman O G; Hoelzer D; Lyman S D; Ganser A
Effects of Flt3 ligand and interleukin-7 on in vitro growth of acute lymphoblastic leukemia cells.
Experimental hematology 1996;24(2):371-7.
1996: Hoelzer D; Ludwig W D; Thiel E; Gassmann W; Löffler H; Fonatsch C; Rieder H; Heil G; Heinze B; Arnold R; Hossfeld D; Büchner T; Koch P; Freund M; Hiddemann W; Maschmeyer G; Heyll A; Aul C; Faak T; Kuse R; Ittel T H; Gramatzki M; Diedrich H; Kolbe K; Fuhr H G; Fischer K; Schadeck-Gressel C; Weiss A; Strohscheer I; Metzner B; Fabry U; Gökbuget N; Völkers B; Messerer D; Uberla K
Improved outcome in adult B-cell acute lymphoblastic leukemia.
Blood 1996;87(2):495-508.
1995: Bergmann L; Karakas T; Lautenschlager G; Jager E; Knuth A; Mitrou P S; Hoelzer D
Vincristine, doxorubicin, cyclophosphamide, prednisone and etoposide (VACPE) in high-grade non-Hodgkin's lymphoma--a multicenter phase II study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(10):1019-24.
1995: Martin H; Atta J; Zumpe P; Eder M; Elsner S; Rode C; Wassmann B; Bruecher J; Hoelzer D
Purging of peripheral blood stem cells yields BCR-ABL-negative autografts in patients with BCR-ABL-positive acute lymphoblastic leukemia.
Experimental hematology 1995;23(14):1612-8.
1995: Bergmann L; Schui D K; Brieger J; Weidmann E; Mitrou P S; Hoelzer D
The inhibition of lymphokine-activated killer cells in acute myeloblastic leukemia is mediated by transforming growth factor-beta 1.
Experimental hematology 1995;23(14):1574-80.
1995: Böhme A; Ganser A; Hoelzer D
Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL.
Annals of hematology 1995;71(6):311-2.
1995: Böhme A; Just-Nübling G; Bergmann L; Shah P M; Stille W; Hoelzer D
A randomized study of imipenem compared to cefotaxime plus piperacillin as initial therapy of infections in granulocytopenic patients.
Infection 1995;23(6):349-55.
1995: Heil G; Mitrou P S; Hoelzer D; Freund M; Link H; Ehninger G; Steinke B; Ohl S; Wandt H; Fackler-Schwalbe E
High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia. Long-term follow-up of a prospective multicenter trial.
Annals of hematology 1995;71(5):219-25.
1995: Dobmeyer T S; Raffel B; Dobmeyer J M; Findhammer S; Klein S A; Kabelitz D; Hoelzer D; Helm E B; Rossol R
Decreased function of monocytes and granulocytes during HIV-1 infection correlates with CD4 cell counts.
European journal of medical research 1995;1(1):9-15.
1995: Brieger J; Weidmann E; Maurer U; Hoelzer D; Mitrou P S; Bergmann L
The Wilms' tumor gene is frequently expressed in acute myeloblastic leukemias and may provide a marker for residual blast cells detectable by PCR.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(8):811-6.
1995: Zhang M J; Hoelzer D; Horowitz M M; Gale R P; Messerer D; Klein J P; Löffler H; Sobocinski K A; Thiel E; Weisdorf D J
Long-term follow-up of adults with acute lymphoblastic leukemia in first remission treated with chemotherapy or bone marrow transplantation. The Acute Lymphoblastic Leukemia Working Committee.
Annals of internal medicine 1995;123(6):428-31.
1995: Fenchel K; Bergmann L; Wijermans P; Engert A; Pralle H; Mitrou P S; Diehl V; Hoelzer D
Clinical experience with fludarabine and its immunosuppressive effects in pretreated chronic lymphocytic leukemias and low-grade lymphomas.
Leukemia & lymphoma 1995;18(5-6):485-92.
1995: Geissler R G; Muth J; Maurer A; Mentzel U; Mag M; Engels J W; Hoelzer D; Ganser A
Modified antisense oligodeoxynucleotides against the splice acceptor site of tat do not inhibit in vitro hematopoietic colony growth in HIV-positive patients.
Annals of hematology 1995;71(2):89-95.
1995: Weidmann E; Brieger J; Bergmann L; Hoelzer D; Mitrou P S
AML blasts variably express interleukin 2 receptor alpha, beta or gamma chains without measurable effects on proliferation, cytokine message expression or surface expression of adhesion molecules upon stimulation with interleukin 2.
Leukemia research 1995;19(7):469-76.
1995: Seipelt G; Hoelzer D
[Current aspects of therapy in chronic and acute leukemias]
Schweizerische medizinische Wochenschrift 1995;125(27-28):1354-63.
1995: Ottmann O G; Hoelzer D; Gracien E; Ganser A; Kelly K; Reutzel R; Lipp T; Busch F W; Schwonzen M; Heil G
Concomitant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult acute lymphoblastic leukemia: a randomized phase III trial.
Blood 1995;86(2):444-50.
1995: Hoelzer D; Seipelt G
Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the treatment of myeloid leukemia.
Current opinion in hematology 1995;2(3):196-203.
1995: Geissler R G; Ganser A; Hübner K; Hör G; Hoelzer D
[47-year-old patient with pulmonary hypertension, anemia and thrombocytopenia]
Der Internist 1995;36(4):385-8.
1995: von Melchner H; Ganser A; Martin H; Grez M; Hoelzer D
[Molecular mechanisms of hematopoietic stem cell differentiation]
Der Internist 1995;36(4):372-7.
1995: Weidmann E; Brieger J; Jahn B; Hoelzer D; Bergmann L; Mitrou P S
Lactate dehydrogenase-release assay: a reliable, nonradioactive technique for analysis of cytotoxic lymphocyte-mediated lytic activity against blasts from acute myelocytic leukemia.
Annals of hematology 1995;70(3):153-8.
1995: Maurer A B; Ganser A; Seipelt G; Ottmann O G; Mentzel U; Geissler G R; Hoelzer D
Changes in erythroid progenitor cell and accessory cell compartments in patients with myelodysplastic syndromes during treatment with all-trans retinoic acid and haemopoietic growth factors.
British journal of haematology 1995;89(3):449-56.
1995: Jahn B; Bergmann L; Weidmann E; Brieger J; Fenchel K; Schwulera U; Hoelzer D; Mitrou P S
Bone marrow-derived T-cell clones obtained from untreated acute myelocytic leukemia exhibit blast directed autologous cytotoxicity.
Leukemia research 1995;19(2):73-82.
1995: Heil G; Chadid L; Hoelzer D; Seipelt G; Mitrou P; Huber C; Kolbe K; Mertelsmann R; Lindemann A; Frisch J
GM-CSF in a double-blind randomized, placebo controlled trial in therapy of adult patients with de novo acute myeloid leukemia (AML).
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(1):3-9.
1995: Bergmann L; Heil G; Kolbe K; Lengfelder E; Puzicha E; Martin H; Lohmeyer J; Mitrou P S; Hoelzer D
Interleukin-2 bolus infusion as late consolidation therapy in 2nd remission of acute myeloblastic leukemia.
Leukemia & lymphoma 1995;16(3-4):271-9.
1994: Brieger J; Weidmann E; Fenchel K; Mitrou P S; Hoelzer D; Bergmann L
The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(12):2138-43.
1994: Wassmann B; Martin H; Elsner S; Bruecher J; Thaiss F; Stahl R A; Hoelzer D
Microangiopathic hemolytic anemia and renal impairment following autologous bone marrow transplantation: a case of hemolytic uremic syndrome?
Bone marrow transplantation 1994;14(5):849-51.
1994: Geissler R G; Ganser A; Ottmann O G; Gute P; Morawetz A; Guba P; Helm E B; Hoelzer D
In vitro improvement of bone marrow-derived hematopoietic colony formation in HIV-positive patients by alpha-D-tocopherol and erythropoietin.
European journal of haematology 1994;53(4):201-6.
1994: Ehninger G; Rutt C M; Ebert A; Harf P; Hoelzer D; Niethammer D; von Keller J; Rodert A; Schuler U
[Accumulation of German bone marrow donor data]
Deutsche medizinische Wochenschrift (1946) 1994;119(40):1359-64.
1994: Messerer D; Neiss A; Horowitz M M; Hoelzer D; Gale R P
Comparison of chemotherapy and bone marrow transplants using two independent clinical databases.
Journal of clinical epidemiology 1994;47(10):1119-26.
1994: Ganser A; Hoelzer D
Acute leukemia.
Current opinion in hematology 1994;1(4):248-55.
1994: Heil G; Gunsilius E; Hoelzer D; Thiel E; Heimpel H
Peroxidase expression in acute unclassified leukemias: ultrastructural studies in combination with immunophenotyping.
Leukemia & lymphoma 1994;14(1-2):103-9.
1994: Hoelzer D
Therapy and prognostic factors in adult acute lymphoblastic leukaemia.
Baillière's clinical haematology 1994;7(2):299-320.
1994: Schubert J; Vogt H G; Zielinska-Skowronek M; Freund M; Kaltwasser J P; Hoelzer D; Schmidt R E
Development of the glycosylphosphatitylinositol-anchoring defect characteristic for paroxysmal nocturnal hemoglobinuria in patients with aplastic anemia.
Blood 1994;83(8):2323-8.
1994: Seipelt G; Ganser A; Duranceyk H; Maurer A; Ottmann O G; Hoelzer D
Induction of soluble IL-2 receptor in patients with myelodysplastic syndromes undergoing high-dose interleukin-3 treatment.
Annals of hematology 1994;68(4):167-70.
1994: Griesinger F; Elfers H; Ludwig W D; Falk M; Rieder H; Harbott J; Lampert F; Heinze B; Hoelzer D; Thiel E
Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11).
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(4):542-8.
1994: Böhme A; Hoelzer D
[Pneumonia after cytostatic drug therapy]
Pneumologie (Stuttgart, Germany) 1994;48(2):121-5.
1994: Martin H; Atta J; Bruecher J; Elsner S; Schardt C; Stadler M; von Melchner H; Hoelzer D
In patients with BCR-ABL-positive ALL in CR peripheral blood contains less residual disease than bone marrow: implications for autologous BMT.
Annals of hematology 1994;68(2):85-7.
1994: Hoelzer D
Treatment of acute lymphoblastic leukemia.
Seminars in hematology 1994;31(1):1-15.
1994: Hoelzer D
Application of hemopoietic growth factors in MDS.
Acta haematologica Polonica 1994;25(2 Suppl 1):104-11.
1993: Martin H; Bruecher J; Claudé R; Hoelzer D
Cumulative chemotherapy increases mafosfamide toxicity for normal progenitor cells in AML patients: rationale for cryopreserving adapted-dose purged marrow early in first complete remission.
Bone marrow transplantation 1993;12(5):495-9.
1993: Maurer A B; Ganser A; Buhl R; Seipelt G; Ottmann O G; Mentzel U; Geissler R G; Hoelzer D
Restoration of impaired cytokine secretion from monocytes of patients with myelodysplastic syndromes after in vivo treatment with GM-CSF or IL-3.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(11):1728-33.
1993: Ganser A; Ottmann O G; Hoelzer D
Interleukin 3 and interleukin 3/GM-CSF combination therapy--clinical implications.
Stem cells (Dayton, Ohio) 1993;11(6):465-73.
1993: Ottmann O G; Ganser A; Freund M; Heil G; Hiddemann W; Heit W; Gracien E; Hoelzer D
Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia. A pilot study.
Annals of hematology 1993;67(4):161-7.
1993: Hoelzer D; Thiel E; Ludwig W D; Löffler H; Büchner T; Freund M; Heil G; Hiddemann W; Maschmeyer G; Völkers B
Follow-up of the first two successive German multicentre trials for adult ALL (01/81 and 02/84). German Adult ALL Study Group.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7 Suppl 2():S130-4.
1993: Seipelt G; Ganser A; Duranceyk H; Maurer A; Ottmann O G; Hoelzer D
Induction of TNF-alpha in patients with myelodysplastic syndromes undergoing treatment with interleukin-3.
British journal of haematology 1993;84(4):749-51.
1993: Ganser A; Hoelzer D
Therapeutic value of interleukin-3 given alone or in combination with other cytokines.
Nouvelle revue française d'hématologie 1993;35(3):245-6.
1993: Hoelzer D
[Acute lymphatic leukemia. Risk factors, chemotherapy/radiotherapy]
Der Internist 1993;34(6):526-33.
1993: Bergmann L; Fenchel K; Jahn B; Mitrou P S; Hoelzer D
Immunosuppressive effects and clinical response of fludarabine in refractory chronic lymphocytic leukemia.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(5):371-5.
1993: Lob S; Bergmann L; Müller H; Jacobi V; Hoelzer D
[Pleomorphic T-cell lymphoma. The diagnostic problems, therapeutic possibilities and infection-induced complications]
Deutsche medizinische Wochenschrift (1946) 1993;118(21):780-4.
1993: Mentzel U; Vogt H; Rossol R; Geissler R G; Maurer A; Ganser A; Trommer W E; Hoelzer D
Analysis of lymphocyte subsets in patients with aplastic anemia before and during immunosuppressive therapy.
Annals of hematology 1993;66(3):127-9.
1993: Hoelzer D F
Therapy of the newly diagnosed adult with acute lymphoblastic leukemia.
Hematology/oncology clinics of North America 1993;7(1):139-60.
1993: Geissler R G; Ottmann O G; Kleiner K; Mentzel U; Bickelhaupt A; Hoelzer D; Ganser A
Decreased haematopoietic colony growth in long-term bone marrow cultures of HIV-positive patients.
Research in virology 1993;144(1):69-73.
1992: Schardt C; Stadler M; Hoelzer D; Ganser A
Lack of c-kit proto-oncogene rearrangement in patients with acute lymphoblastic leukemia (ALL) and the t(4;11)(q21;q23) translocation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(10):1079-80.
1992: Ganser A; Hoelzer D
Clinical course of myelodysplastic syndromes.
Hematology/oncology clinics of North America 1992;6(3):607-18.
1992: Eder M; Ottmann O G; Hansen-Hagge T E; Bartram C R; Falk S; Gillis S; Hoelzer D; Ganser A
In vitro culture of common acute lymphoblastic leukemia blasts: effects of interleukin-3, interleukin-7, and accessory cells.
Blood 1992;79(12):3274-84.
1992: Ganser A; Hoelzer D
Treatment of myelodysplastic syndromes with hematopoietic growth factors.
Hematology/oncology clinics of North America 1992;6(3):633-53.
1992: Schardt C; Ottmann O G; Hoelzer D; Ganser A
Acute lymphoblastic leukemia with the (4;11) translocation: combined cytogenetic, immunological and molecular genetic analyses.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(5):370-4.
1992: Geissler R G; Ottmann O G; Kojouharoff G; Reutzel P; Eder M; Hoelzer D; Ganser A
Influence of human recombinant interferon-alpha and interferon-gamma on bone marrow progenitor cells of HIV-positive individuals.
AIDS research and human retroviruses 1992;8(4):521-5.
1992: Ganser A; Seipelt G; Eder M; Geissler G; Ottmann O G; Hess U; Hoelzer D
Treatment of myelodysplastic syndromes with cytokines and cytotoxic drugs.
Seminars in oncology 1992;19(2 Suppl 4):95-101.
1992: Götz G; Weh H J; Walter T A; Kuse R; Kolbe K; Dölken G; Hellriegel K P; Hoelzer D; Hossfeld D K
Clinical and prognostic significance of the Philadelphia chromosome in adult patients with acute lymphoblastic leukemia.
Annals of hematology 1992;64(2):97-100.
1992: Schardt C; Hoelzer D; Ganser A
Presence of more than two rearranged immunoglobulin heavy-chain genes in adult precursor B-cell acute lymphoblastic leukemia.
Annals of hematology 1992;64(2):72-7.
1992: Hess U; Ganser A; Schnürch H G; Seipelt G; Ottmann O G; Falk S; Schulz G; Hoelzer D
Myelokathexis treated with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF).
British journal of haematology 1992;80(2):254-6.
1992: Hoelzer D; Thiel E; Ludwig W D; Löffler H; Büchner T; Freund M; Heil G; Hiddemann W; Maschmeyer G; Völkers B
The German multicentre trials for treatment of acute lymphoblastic leukemia in adults. The German Adult ALL Study Group.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6 Suppl 2():175-7.
1992: Hoelzer D
Therapy of acute lymphoblastic leukemia in adults.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6 Suppl 2():132-5.
1992: Frisch J; Ganser A; Hoelzer D; Brugger W; Kanz L; Mertelsmann R; Schulz G
Interleukin-3 and granulocyte-macrophage colony-stimulating factor in combination: clinical implication.
Medical and pediatric oncology. Supplement 1992;2():34-7.
1991: Lindemann A; Ganser A; Herrmann F; Frisch J; Seipelt G; Schulz G; Hoelzer D; Mertelsmann R
Biologic effects of recombinant human interleukin-3 in vivo.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(12):2120-7.
1991: Geissler R G; Ganser A; Ottmann O G; Kojouharoff G; Reutzel P; Andries K; Schellekens K; Hoelzer D
TIBO R82913, a new HIV-1 inhibiting agent, does not inhibit hematopoietic progenitor cells.
AIDS research and human retroviruses 1991;7(12):1021-3.
1991: Ganser A; Ottmann O G; Seipelt G; Hess U; Geissler G; Merget R; Falk S; Maurer A; Eder M; Hoelzer D
Preclinical and clinical evaluation of interleukin 3.
Behring Institute Mitteilungen 1991;(90):50-61.
1991: Ottmann O G; Stella C C; Eder M; Reutzel P; Ströcker S; Hoelzer D; Ganser A
Regulation of early hematopoiesis in serum-deprived cultures of mafosfamide-treated and untreated CD34-enriched bone marrow cells.
Experimental hematology 1991;19(8):773-8.
1991: Horowitz M M; Messerer D; Hoelzer D; Gale R P; Neiss A; Atkinson K; Barrett A J; Büchner T; Freund M; Heil G
Chemotherapy compared with bone marrow transplantation for adults with acute lymphoblastic leukemia in first remission.
Annals of internal medicine 1991;115(1):13-8.
1991: Hoelzer D
High-dose chemotherapy in adult acute lymphoblastic leukemia.
Seminars in hematology 1991;28(3 Suppl 4):84-9.
1991: Lob S; Bergmann L; Müller H; Hoelzer D
[Pleomorphic T-cell lymphoma. Its diagnosis and the therapeutic possibilities]
Deutsche medizinische Wochenschrift (1946) 1991;116(25):986-91.
1991: Geissler R G; Ottmann O G; Eder M; Kojouharoff G; Hoelzer D; Ganser A
Effect of recombinant human transforming growth factor beta and tumor necrosis factor alpha on bone marrow progenitor cells of HIV-infected persons.
Annals of hematology 1991;62(5):151-5.
1991: Lindemann A; Ganser A; Hoelzer D; Mertelsmann R; Herrmann F
In vivo administration of recombinant human interleukin-3 elicits an acute phase response involving endogenous synthesis of interleukin-6.
European cytokine network 1991;2(3):173-6.
1991: Hoelzer D; Seipelt G; Ganser A
Interleukin 3 alone and in combination with GM-CSF in the treatment of patients with neoplastic disease.
Seminars in hematology 1991;28(2 Suppl 2):17-24.
1991: Falk S; Seipelt G; Ganser A; Ottmann O G; Hoelzer D; Stutte H J; Hübner K
Bone marrow findings after treatment with recombinant human interleukin-3.
American journal of clinical pathology 1991;95(3):355-62.
1991: Kojouharoff G; Ottmann O G; von Briesen H; Geissler G; Rübsamen-Waigmann H; Hoelzer D; Ganser A
Infection of granulocyte/monocyte progenitor cells with HIV1.
Research in virology 1991;142(2-3):151-7.
1991: Heil G; Gunsilius E; Raghavachar A; Bartram C R; Ganser A; Kurrle E; Aydemir U; Löffler H; Hoelzer D; Thiel E
Ultrastructural demonstration of peroxidase expression in acute unclassified leukemias: correlation to immunophenotype and treatment outcome.
Blood 1991;77(6):1305-12.
1991: Messerer D; Neiss A; Aydemir U; Hoelzer D; Arnold R
How can disease-free survival of adult ALL patients with or without transplants be compared?
Onkologie 1991;14(1):53-5.
1991: Ganser A; Lindemann A; Seipelt G; Ottmann O G; Herrmann F; Eder M; Frisch J; Schulz G; Mertelsmann R; Hoelzer D
Clinical effects of recombinant human interleukin-3.
American journal of clinical oncology 1991;14 Suppl 1():S51-63.
1991: Ganser A; Seipelt G; Hoelzer D
The role of GM-CSF, G-CSF, interleukin-3, and erythropoietin in myelodysplastic syndromes.
American journal of clinical oncology 1991;14 Suppl 1():S34-9.
1991: Koberda J; Bergmann L; Mitrou P S; Hoelzer D
High release of tumor necrosis factor alpha, interferon gamma and interleukin-6 by adherent lymphokine-activated killer cells phenotypically derived from T cells.
Journal of cancer research and clinical oncology 1991;117(5):425-30.
1991: Ganser A; Lindemann A; Seipelt G; Ottmann O G; Eder M; Herrmann F; Frisch J; Schulz G; Mertelsmann R; Hoelzer D
Recombinant human interleukin-3 in patients with hematopoietic failure.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1991;121():162-72.
1991: Seipelt G; Ganser A; Hoelzer D
Hemopoietic growth factors in the treatment of acute leukemias and myelodysplastic syndromes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1991;121():141-54.
1991: Herrmann F; Mertelsmann R; Lindemann A; Ottmann O G; Seipelt G; Oster W; Hoelzer D; Ganser A
Clinical use of recombinant human hematopoietic growth factors (GM-CSF, IL-3, EPO) in patients with myelodysplastic syndrome.
Biotechnology therapeutics 1991;2(3-4):299-311.
1990: Ottmann O G; Ganser A; Seipelt G; Eder M; Schulz G; Hoelzer D
Effects of recombinant human interleukin-3 on human hematopoietic progenitor and precursor cells in vivo.
Blood 1990;76(8):1494-502.
1990: Eder M; Ottmann O G; Hansen-Hagge T E; Bartram C R; Gillis S; Hoelzer D; Ganser A
Effects of recombinant human IL-7 on blast cell proliferation in acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1990;4(8):533-40.
1990: Ganser A; Lindemann A; Seipelt G; Ottmann O G; Herrmann F; Eder M; Frisch J; Schulz G; Mertelsmann R; Hoelzer D
Effects of recombinant human interleukin-3 in patients with normal hematopoiesis and in patients with bone marrow failure.
Blood 1990;76(4):666-76.
1990: Hoelzer D
Change in treatment strategies for adult acute lymphoblastic leukemia (ALL) according to prognostic factors and minimal residual disease.
Bone marrow transplantation 1990;6 Suppl 1():66-70.
1990: Ganser A; Ottmann O G; von Briesen H; Völkers B; Rübsamen-Waigmann H; Hoelzer D
Changes in the haematopoietic progenitor cell compartment in the acquired immunodeficiency syndrome.
Research in virology 1990;141(2):185-93.
1990: Hoelzer D; Ganser A; Ottmann O G; Höffken K; Becher R; Lutz D; Krieger O; Diehl V; Lathan B; Boogaerts M A
Effect of treatment with rhGM-CSF and low-dose cytosine arabinoside on leukemic blast cells in patients with myelodysplastic syndromes.
Haematology and blood transfusion 1990;33():763-9.
1990: Ehninger G; Fackler-Schwalbe E; Freund M; Heil G; Henke M; Hoelzer D; Hoffmann R; Kurrle E; Link H; Lösch A
Combination of mitoxantrone and etoposide in patients aged over 60 years with untreated acute myelogenous leukemia.
Haematology and blood transfusion 1990;33():316-7.
1990: Kurrle E; Ehninger G; Fackler-Schwalbe E; Freund M; Heil G; Hoelzer D; Link H; Löffler B; Lösch A; Mitrou P S
Consolidation therapy with high-dose cytosine arabinoside: experiences of a prospective study in acute myeloid leukemia.
Haematology and blood transfusion 1990;33():254-60.
1990: Heil G; Gunsilius E; Raghavachar A N; Kurrle E; Hoelzer D; Heimpel H; Thiel E
Correlation between the expression of myelomonocytic surface antigens and ultrastructural demonstration of early myeloperoxidase expression in null-AL(L) cells.
Haematology and blood transfusion 1990;33():67-71.
1990: Seipelt G; Ottmann O G; Ganser A; Eder M; Lindemann A; Falk S; Stutte H J; Hübner K; Mertelsmann R; Hoelzer D
[In vitro and in vivo effects of recombinant human interleukin-3 on hematopoietic progenitor cells]
Verhandlungen der Deutschen Gesellschaft für Pathologie 1990;74():116-9.
1990: Falk S; Seipelt G; Ganser A; Hoelzer D; Stutte H J; Hübner K
[Effects on bone marrow during stimulation of hematopoietic stem cells with recombinant human interleukin-3]
Verhandlungen der Deutschen Gesellschaft für Pathologie 1990;74():111-5.
1990: Merget R D; Maurer A B; Koch U; Ganser A; Ottmann O G; Schultze-Werninghaus G; Seipelt G; Zachgo W; Hoelzer D; Meier-Sydow J
Histamine release from basophils after in vivo application of recombinant human interleukin-3 in man.
International archives of allergy and applied immunology 1990;92(4):366-74.
1989: Ganser A; Ottmann O G; Erdmann H; Schulz G; Hoelzer D
The effect of recombinant human granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity in chronic severe neutropenia.
Annals of internal medicine 1989;111(11):887-92.
1989: Ganser A; Bergmann M; Völkers B; Grützmacher P; Scigalla P; Hoelzer D
In vivo effects of recombinant human erythropoietin on circulating human hemopoietic progenitor cells.
Experimental hematology 1989;17(5):433-5.
1989: Völkers B; Ganser A; Greher J; Stella C C; Hoelzer D
[Effect of tumor necrosis factor on human hematopoietic precursor cells]
Onkologie 1989;12(3):109-15.
1989: Ganser A; Greher J; Völkers B; Staszewski S; Hoelzer D
Inhibitory effect of azidothymidine, 2'-3'-dideoxyadenosine, and 2'-3'-dideoxycytidine on in vitro growth of hematopoietic progenitor cells from normal persons and from patients with AIDS.
Experimental hematology 1989;17(4):321-5.
1989: Ganser A; Ottmann O G; Schulz G; Hoelzer D
Recombinant human granulocyte-macrophage colony-stimulating factor and low-dose cytosine arabinoside in patients with myelodysplastic syndrome. A pilot study.
Onkologie 1989;12(1):13-5.
1989: Hoelzer D
Which factors influence the different outcome of therapy in adults and children with ALL?
Bone marrow transplantation 1989;4 Suppl 1():98-100.
1989: Ganser A; Völkers B; Greher J; Ottmann O G; Walther F; Becher R; Bergmann L; Schulz G; Hoelzer D
Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase I/II trial.
Blood 1989;73(1):31-7.
1988: Carlo-Stella C; Cazzola M; Ganser A; Bergamaschi G; Pedrazzoli P; Hoelzer D; Ascari E
Synergistic antiproliferative effect of recombinant interferon-gamma with recombinant interferon-alpha on chronic myelogenous leukemia hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM).
Blood 1988;72(4):1293-9.
1988: Grünwald S; Driever P H; Hoelzer D; Drahovsky D
Reduced methyl group acceptance of 1-beta-D-arabinofuranosylcytosine-containing DNA polymers.
Biochimica et biophysica acta 1988;950(3):366-73.
1988: Ganser A; Völkers B; Greher J; Hoelzer D
Effect of recombinant human granulocyte-macrophage colony-stimulating factor on the hemopoietic progenitor cells from patients with AIDS.
Behring Institute Mitteilungen 1988;(83):284-8.
1988: Hoelzer D; Ganser A; Greher J; Völkers B; Walther F
Phase I/II study with GM-CSF in patients with myelodysplastic syndromes.
Behring Institute Mitteilungen 1988;(83):134-8.
1988: Kurrle E; Ehninger G; Freund M; Heil G; Hoelzer D; Link H; Mitrou P S; Ohl S; Queisser W; Schlimok G
A multicentre study on intensive induction and consolidation therapy in acute myelogenous leukaemia.
Blut 1988;56(5):233-6.
1988: Kreuser E D; Hetzel W D; Heit W; Hoelzer D; Kurrle E; Xiros N; Heimpel H
Reproductive and endocrine gonadal functions in adults following multidrug chemotherapy for acute lymphoblastic or undifferentiated leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(4):588-95.
1988: Ganser A; Völkers B; Scigalla P; Hoelzer D
Effect of human recombinant erythropoietin on human hemopoietic progenitor cells in vitro.
Klinische Wochenschrift 1988;66(6):236-40.
1988: Ganser A; Völkers B; Greher J; Walther F; Hoelzer D
Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase-I/II trial.
Onkologie 1988;11(1):53-5.
1988: Kurrle E; Ehninger G; Freund M; Heil G; Hoelzer D; Link H; Mitrou P S; Ohl S; Queisser W; Schlimok G
[Induction and intensive combined therapy of acute myeloid leukemia in adults]
Onkologie 1988;11(1):5-9.
1988: Hoelzer D; Thiel E; Löffler H; Büchner T; Ganser A; Heil G; Kurrle E; Heimpel H; Koch P; Lipp T
[Intensive combined therapy for high-risk ALL patients]
Onkologie 1988;11(1):18-24.
1988: Carlo Stella C; Cazzola M; Ganser A; Bergamaschi G; Meloni F; Pedrazzoli P; Bernasconi P; Invernizzi R; Hoelzer D; Ascari E
Recombinant gamma-interferon induces in vitro monocytic differentiation of blast cells from patients with acute nonlymphocytic leukemia and myelodysplastic syndromes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(1):55-9.
1988: Heil G; Ganser A; Raghavachar A; Kurrle E; Heit W; Hoelzer D; Heimpel H
Induction of myeloperoxidase in five cases of acute unclassified leukaemia.
British journal of haematology 1988;68(1):23-32.
1988: Ganser A; Bergmann M; Völkers B; Grützmacher P; Hoelzer D
In vitro and in vivo effects of recombinant human erythropoietin on human hemopoietic progenitor cells.
Contributions to nephrology 1988;66():123-30.
1988: Hoelzer D
Cytobiology and clinical findings of myelodysplastic syndromes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1988;106():172-9.
1988: Hoelzer D; Ganser A; Völkers B; Greher J; Walther F
In vitro and in vivo action of recombinant human GM-CSF (rhGM-CSF) in patients with myelodysplastic syndromes.
Blood cells 1988;14(2-3):551-9.
1987: Ganser A; Carlo-Stella C; Greher J; Völkers B; Hoelzer D
Effect of recombinant interferons alpha and gamma on human bone marrow-derived megakaryocytic progenitor cells.
Blood 1987;70(4):1173-9.
1987: Carlo-Stella C; Cazzola M; Gasner A; Barosi G; Dezza L; Meloni F; Pedrazzoli P; Hoelzer D; Ascari E
Effects of recombinant alpha and gamma interferons on the in vitro growth of circulating hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) from patients with myelofibrosis with myeloid metaplasia.
Blood 1987;70(4):1014-9.
1987: Hoelzer D; Thiel E; Löffler H; Büchner T; Ganser A; Heil G; Kurrle E; Heimpel H; Koch P; Lipp T
Teniposide (VM-26) and cytosine arabinoside as consolidation therapy in adult high-risk patients with acute lymphoblastic leukemia.
Seminars in oncology 1987;14(2 Suppl 1):92-7.
1987: Messerer D; Hasford J; Hoelzer D; Neiss A; Zwingers T
Pitfalls in the evaluation of prognostic factors.
Haematology and blood transfusion 1987;30():308-12.
1987: Ganser A; Carlo Stella C; Völkers B; Brodt K H; Helm E B; Hoelzer D
Loss of hematopoietic progenitor cells CFU-GEMM, BFU-E, CFU-Mk, and CFU-GM in the acquired immunodeficiency syndrome (AIDS)?
Haematology and blood transfusion 1987;31():175-6.
1985: Hoelzer D; Thiel E; Löffler H; Bodenstein H; Büchner T; Engelhardt R; Ganser A; Messerer D; Rühl H; Zwingers T
Risk groups in a multicenter pilot study for treatment of acute lymphoblastic and acute undifferentiated leukemia in adults.
Haematology and blood transfusion 1985;29():48-50.
1983: Hoelzer D; Thiel E; Löffler H; Bodenstein H; Büchner T; Messerer D
Multicentre pilot study for therapy of acute lymphoblastic and acute undifferentiated leukemia in adults.
Haematology and blood transfusion 1983;28():36-40.

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