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Dieter Hoelzer

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Gianni Capalbo; Dieter Hoelzer; Hans-Ulrich Klein; Steffen Koschmieder; Thea Mueller-Kuller; Oliver G Ottmann; Urban J Scheuring
Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.
Ebru Coskun; Nicola Goekbuget; Sandra Heesch; Dieter Hoelzer; Frauke Liebertz; Martin Neumann; Cornelia Schlee; Claudia D Baldus
MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia.
Sandra Heesch; Michael Heuser; Dieter Hoelzer; Wolf-Karsten Hofmann; Martin Neumann; Cornelia Schlee; Stefan Schwartz; Eckhard Thiel; Clemens-Martin Wendtner; Isabelle Bartram; Wolfgang E Berdel; Thomas Burmeister; Arnold Ganser; Nicola Gökbuget; Matthias Hänel; Claudia D Baldus
Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization.

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2013: Gianni Capalbo; Dieter Hoelzer; Hans-Ulrich Klein; Steffen Koschmieder; Thea Mueller-Kuller; Oliver G Ottmann; Urban J Scheuring
Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.
International journal of oncology 2013;43(1):246-54.
2013: Ebru Coskun; Nicola Goekbuget; Sandra Heesch; Dieter Hoelzer; Frauke Liebertz; Martin Neumann; Cornelia Schlee; Claudia D Baldus
MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia.
Leukemia research 2013;37(6):647-56.
2013: Sandra Heesch; Michael Heuser; Dieter Hoelzer; Wolf-Karsten Hofmann; Martin Neumann; Cornelia Schlee; Stefan Schwartz; Eckhard Thiel; Clemens-Martin Wendtner; Isabelle Bartram; Wolfgang E Berdel; Thomas Burmeister; Arnold Ganser; Nicola Gökbuget; Matthias Hänel; Claudia D Baldus
Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization.
Annals of hematology 2013;92(6):747-58.
2013: Mathias J Rummel; Martina Stauch; Ulrich von Grünhagen; Eckhart Weidmann; Manfred Welslau; Harald Ballo; C Balser; G Andre Banat; Juergen Barth; Wolfram Brugger; Heinz Duerk; Gerhard Heil; Axel Hinke; Dieter Hoelzer; Ulrich Kaiser; Dorothea Kofahl-Krause; Christoph Losem; Georg Maschmeyer; Norbert Niederle; Fritz Roller
Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non-inferiority trial.
Lancet 2013;381(9873):1203-10.
2013: Thorsten Raff; Regina Reutzel; Matthias Ritgen; H Trautmann; Nicola Gökbuget; Dieter Hoelzer; M Kaiser; Michael Kneba; Silke Lüschen; Monika Brüggemann
Uncovering early, lineage-dependent effects of TPMT genotype in adult acute lymphoblastic leukemia by minimal residual disease.
Leukemia 2013;27(4):989-92.
2013: Martin Neumann; Cornelia Schlee; Stefan Schwartz; Eckhard Thiel; Nasrin Farhadi Sartangi; Isabelle Bartram; Olga Blau; Christian Brandts; Thomas Burmeister; Ebru Coskun; Hartmut Döhner; Ulrich Dührsen; Gerhard Ehninger; Lars Fransecky; Nicola Gökbuget; Martin Griesshammer; Rainer Haas; Sandra Heesch; Dieter Hoelzer; Wolf-Karsten Hofmann; Liliana H Mochmann; Claudia D Baldus
FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors.
PloS one 2013;8(1):e53190.
2012: Max S Topp; Andreas Viardot; Gerhard Zugmaier; Patrick A Baeuerle; Monika Brüggemann; Thomas Burmeister; Evelyn Degenhard; Hermann Einsele; Marie-Elisabeth Goebeler; Nicola Gökbuget; Dieter Hoelzer; Heinz A Horst; Matthias Klinger; Michael Kneba; Rudolf Köhne-Volland; Peter Kufer; Dirk Nagorsen; Svenja A Neumann; Oliver G Ottmann; Thorsten Raff; Gert Riethmüller; Markus Schaich; Margit Schmidt; Matthias Stelljes; Ralf C Bargou
Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL.
Blood 2012;120(26):5185-7.
2012: Seval Türkmen; Gesine Bartels; Nicola Gökbuget; Daniela Gröger; Claudia Haferlach; Dieter Hoelzer; Rolf Marschalek; Claus Meyer; Harald Rieder; Stefan Schwartz; Bernd Timmermann; Thomas Burmeister
Involvement of the MLL gene in adult T-lymphoblastic leukemia.
Genes, chromosomes & cancer 2012;51(12):1114-24.
2012: Patrick Brück; Dieter Hoelzer; Marta Kaluzna-Oleksy; Malgorzata Pierzchlewska; Maria Elizabeth Ramos Lopez; Mathias Rummel; Angelika Böhme
Dying of hematologic patients--treatment characteristics in a German University Hospital.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2012;20(11):2895-902.
2012: Thomas Büchner; Hartmut Döhner; Konstanze Döhner; Gerhard Ehninger; Arnold Ganser; Joerg Hasford; Rüdiger Hehlmann; Gerhard Heil; Achim Heinecke; Wolfgang Hiddemann; Dieter Hoelzer; Verena S Hoffmann; Rainer Krahl; Michael Kramer; Jürgen Krauter; Utz Krug; Dietger W Niederwieser; Maria Cristina Sauerland; Markus Schaich; Richard F Schlenk; Sebastian Scholl; Daniela Späth; Wolfgang E Berdel; Markus Pfirrmann
Acute Myeloid Leukemia (AML): different treatment strategies versus a common standard arm--combined prospective analysis by the German AML Intergroup.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(29):3604-10.
2012: Nicola Gökbuget; Dieter Hoelzer; Heinz-August Horst; Andreas Hüttmann; Guido Kobbe; Karl-Anton Kreuzer; Lothar Leimer; Albrecht Reichle; Markus Schaich; Stefan Schwartz; Hubert Serve; Daniel Stanze; Michael Starck; Matthias Stelljes; Reingard Stuhlmann; Andreas Viardot; Knut Wendelin; Joachim Beck; Helmut Diedrich; Mathias Freund
Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation.
Blood 2012;120(10):2032-41.
2012: Nicola Gökbuget; Dieter Hoelzer; Michael Kneba; Wolf-Dieter Ludwig; Georg Maschmeyer; Thorsten Raff; Harald Rieder; Stefan Schwartz; Hubert Serve; Eckhard Thiel; Heiko Trautmann; Renate Arnold; Claus-Rainer Bartram; Monika Brüggemann; Rainer Fietkau; Mathias Freund; Arnold Ganser
Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies.
Blood 2012;120(9):1868-76.
2012: Heike Pfeifer; M Schmalzing; A Schmidt; Hubert Serve; Matthias Stelljes; Barbara Wassmann; Lydia Wunderle; S Wystub; Anja Binckebanck; Patrick Brück; Ulrich Dührsen; Aristoteles Giagounidis; Dieter Hoelzer; Thoralf Lange; J Maier; Oliver G Ottmann
Prevalence and dynamics of bcr-abl kinase domain mutations during imatinib treatment differ in patients with newly diagnosed and recurrent bcr-abl positive acute lymphoblastic leukemia.
Leukemia 2012;26(7):1475-81.
2012: Matthias Klinger; Dirk Nagorsen; Svenja Neumann; Matthias Stelljes; Max S Topp; Andreas Viardot; Andreas Wolf; Gerhard Zugmaier; Patrick A Baeuerle; Ralf C Bargou; Christian Brandl; Monika Brüggemann; Evelyn Degenhard; Mariele Goebeler; Nicola Gökbuget; Youssef Hijazi; Dieter Hoelzer; Peter Kufer
Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab.
Blood 2012;119(26):6226-33.
2012: Sabine Mousset; Susanne Kriener; Hans Martin; Annemarie Berger; Gesine Bug; K Engels; S Heß; Dieter Hoelzer; Stefan A Klein
Human herpesvirus 6 in biopsies from patients with gastrointestinal symptoms after allogeneic stem cell transplantation.
Annals of hematology 2012;91(5):737-42.
2012: Dieter Hoelzer
Anti-CD22 therapy in acute lymphoblastic leukaemia.
The lancet oncology 2012;13(4):329-31.
2012: Olaf Hopfer; Anke Kmetsch; Martina Komor; Maximilan Mossner; Florian Nolte; Daniel Nowak; Monika Reissmann; Eckhard Thiel; Ouidad Benslasfer; Dieter Hoelzer; Wolf-Karsten Hofmann
Epigenetic dysregulation of GATA1 is involved in myelodysplastic syndromes dyserythropoiesis.
European journal of haematology 2012;88(2):144-53.
2012: Gianni Capalbo; Dieter Hoelzer; Thea Müller-Kuller; Oliver G Ottmann; Urban J Scheuring
HIV-1 infection suppresses expression of host cell cycle-associated gene PDS5A.
Intervirology 2012;55(4):263-75.
2011: Gianni Capalbo; Ursula Dietrich; Dieter Hoelzer; Stefan A Klein; Sandra Markovic; Thea Mueller-Kuller; Oliver G Ottmann; Urban J Scheuring
Knockdown of ERM family member moesin in host cells increases HIV type 1 replication.
AIDS research and human retroviruses 2011;27(12):1317-22.
2011: Thomas Burmeister; Daniela Gröger; Dieter Hoelzer; Anett Kühn; Eckhard Thiel; Richard Reinhardt
Fine structure of translocation breakpoints within the major breakpoint region in BCR-ABL1-positive leukemias.
DNA repair 2011;10(11):1131-7.
2011: Annette Deichmann; Cynthia E Dunbar; Alain Fischer; Richard Gabriel; H Bobby Gaspar; Hanno Glimm; Manuel Grez; Salima Hacein-Bey-Abina; Dieter Hoelzer; Steven J Howe; Fulvio Mavilio; Marion G Ott; Anna Paruzynski; Manfred Schmidt; Kerstin Schwarzwaelder; Reinhard Seger; Adrian J Thrasher; Monique M A Verstegen; Christof von Kalle; Ulrich Abel; Alessandro Aiuti; Anne Arens; Cynthia C Bartholomae; Christopher Baum; Martijn Brugman; Barbara Cassani; Claudia Cattoglio; Marina Cavazzana-Calvo; Gerard Wagemaker
Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(11):2031-9.
2011: Nicola Gökbuget; Björn Güldenzoph; Gernot Hartung; Nadezda Basara; Herrad Baurmann; Joachim Beck; Monika Brüggemann; Helmut Diedrich; Heinz-August Horst; Andreas Hüttmann; Guido Kobbe; Ralph Naumann; Richard Ratei; Albrecht Reichle; Hubert Serve; Matthias Stelljes; Andreas Viardot; Mohammed Wattad; Dieter Hoelzer
High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation.
Blood 2011;118(13):3504-11.
2011: Sergio Cortelazzo; Andrés J M Ferreri; Maurilio Ponzoni; Dieter Hoelzer
Lymphoblastic lymphoma.
Critical reviews in oncology/hematology 2011;79(3):330-43.
2011: Felicitas Thol; Katharina Wagner; Claudia Winschel; Haiyang Yun; Frederik Damm; Walter Fiedler; Arnold Ganser; Gudrun Göhring; Gerhard Heil; Dieter Hoelzer; Lothar Kanz; Hartmut Kirchner; Jürgen Krauter; Michael Lübbert; Andrea Lüdeking; Michael Morgan; Brigitte Schlegelberger; Michael Heuser
Incidence and prognostic influence of DNMT3A mutations in acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(21):2889-96.
2011: Stefan A Klein; Gesine Bug; Dieter Hoelzer; Wolf-Karsten Hofmann; Sabine Mousset; Hans Martin
Long term outcome of patients with steroid-refractory acute intestinal graft versus host disease after treatment with pentostatin.
British journal of haematology 2011;154(1):143-6.
2011: Max S Topp; Andreas Viardot; Gerhard Zugmaier; Patrick A Baeuerle; Monika Brüggemann; Thomas Burmeister; Evelyn Degenhard; Hermann Einsele; Mariele Goebeler; Nicola Gökbuget; Dieter Hoelzer; Heinz-A Horst; Matthias Klinger; Michael Kneba; Rudolf Köhne-Volland; Peter Kufer; Ralf Lutterbuese; Dirk Nagorsen; Svenja Neumann; Oliver Ottmann; Heike Pfeifer; Thorsten Raff; Carsten Reinhardt; Gert Riethmüller; Markus Schaich; Mathias Schmid; Margit Schmidt; Matthias Stelljes; Ralf C Bargou
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(18):2493-8.
2011: Gero Hütter; Martin Kaiser; Martin Neumann; Maximilian Mossner; Daniel Nowak; Claudia D Baldus; Nicola Gökbuget; Dieter Hoelzer; Eckhard Thiel; Wolf-Karsten Hofmann
Epigenetic regulation of PAX5 expression in acute T-cell lymphoblastic leukemia.
Leukemia research 2011;35(5):614-9.
2011: Blanca Xicoy; Salut Brunet; Julián de la Torre; Jordi Esteve; Dieter Hoelzer; José La Cruz; Beatriz Mahillo; Pilar Miralles; Mireia Morgades; Albert Oriol; Josep María Ribera; María Jesús Téllez; Eulalia Valencia
Comparison of CHOP treatment with specific short-intensive chemotherapy in AIDS-related Burkitt's lymphoma or leukemia.
Medicina clínica 2011;136(8):323-8.
2011: Renato Bassan; Dieter Hoelzer
Modern therapy of acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(5):532-43.
2011: Nicola Gökbuget; Christina-Maria Hartog; Renato Bassan; Heinz-Gerd Derigs; Hervé Dombret; Richard Greil; Jesus-Maria Hernández-Rivas; Francoise Huguet; Tamara Intermesoli; Eric Jourdan; Christian Junghanss; Lothar Leimer; Maria-Jose Moreno; Albrecht Reichle; Josep Ribera; Matthias Schmid; Hubert Serve; Matthias Stelljes; Reingard Stuhlmann; Dieter Hoelzer
Liposomal cytarabine is effective and tolerable in the treatment of central nervous system relapse of acute lymphoblastic leukemia and very aggressive lymphoma.
Haematologica 2011;96(2):238-44.
2011: Ebru Coskun; Eva Kristin von der Heide; Cornelia Schlee; Andrea Kühnl; Nicola Gökbuget; Dieter Hoelzer; Wolf-Karsten Hofmann; Eckhard Thiel; Claudia D Baldus
The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia.
Leukemia research 2011;35(2):208-13.
2011: Michael Heuser; Arnold Ganser; Dieter Hoelzer
The hematopoietic growth factors in acute leukemia: a European perspective.
Cancer treatment and research 2011;157():339-62.
2011: Sandra Heesch; Isabelle Bartram; Martin Neumann; Jana Reins; Maximilian Mossner; Cornelia Schlee; Andrea Stroux; Torsten Haferlach; Nicola Goekbuget; Dieter Hoelzer; Wolf-Karsten Hofmann; Eckhard Thiel; Claudia D Baldus
Expression of IGFBP7 in acute leukemia is regulated by DNA methylation.
Cancer science 2011;102(1):253-9.
2010: Gianni Capalbo; Thea Müller-Kuller; Ursula Dietrich; Dieter Hoelzer; Oliver G Ottmann; Urban J Scheuring
Inhibition of X4-tropic HIV type 1 replication by knockdown of the cellular protein LEREPO4.
AIDS research and human retroviruses 2010;26(10):1155-61.
2010: Saskia Gueller; Martina Komor; Daniel Nowak; Claudia D Baldus; Sven de Vos; Dieter Hoelzer; Oliver G Ottmann; Wolf-Karsten Hofmann
Identification of defects in the transcriptional program during lineage-specific in vitro differentiation of CD34(+) cells selected from patients with both low- and high-risk myelodysplastic syndrome.
Experimental hematology 2010;38(9):718-32, 732.e1-6.
2010: S Heesch; C Schlee; M Neumann; Andrea Stroux; A Kühnl; Stefan Schwartz; T Haferlach; Nicola Goekbuget; Dieter Hoelzer; Eckhard Thiel; Wolf-Karsten Hofmann; Claudia D Baldus
BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia.
Leukemia 2010;24(8):1429-36.
2010: Felicitas Thol; Frederik Damm; Katharina Wagner; Gudrun Göhring; Brigitte Schlegelberger; Dieter Hoelzer; Michael Lübbert; Wolfgang Heit; Lothar Kanz; Günter Schlimok; Aruna Raghavachar; Walter Fiedler; Hartmut Kirchner; Gerhard Heil; Michael Heuser; Jürgen Krauter; Arnold Ganser
Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia.
Blood 2010;116(4):614-6.
2010: Sandra Heesch; Nicola Goekbuget; Andrea Stroux; Jutta Ortiz Tanchez; Cornelia Schlee; Thomas Burmeister; Stefan Schwartz; Olga Blau; Ulrich Keilholz; Antonia Busse; Dieter Hoelzer; Eckhard Thiel; Wolf-Karsten Hofmann; Claudia D Baldus
Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia.
Haematologica 2010;95(6):942-9.
2010: Andrea Kühnl; Nicola Gökbuget; Andrea Stroux; Thomas Burmeister; Martin Neumann; Sandra Heesch; Torsten Haferlach; Dieter Hoelzer; Wolf-Karsten Hofmann; Eckhard Thiel; Claudia D Baldus
High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia.
Blood 2010;115(18):3737-44.
2010: Stefan Faderl; Susan O'Brien; Ching-Hon Pui; Wendy Stock; Meir Wetzler; Dieter Hoelzer; Hagop M Kantarjian
Adult acute lymphoblastic leukemia: concepts and strategies.
Cancer 2010;116(5):1165-76.
2010: Bruce D Cheson; Clemens-Martin Wendtner; Angelika Pieper; Martin Dreyling; Jonathan Friedberg; Dieter Hoelzer; Philippe Moreau; John Gribben; Stefan Knop; Marco Montillo; Mathias Rummel
Optimal use of bendamustine in chronic lymphocytic leukemia, non-Hodgkin lymphomas, and multiple myeloma: treatment recommendations from an international consensus panel.
Clinical lymphoma, myeloma & leukemia 2010;10(1):21-7.
2010: Stefan Stein; Marion G Ott; Stephan Schultze-Strasser; Anna Jauch; Barbara Burwinkel; Andrea Kinner; Manfred Schmidt; Alwin Krämer; Joachim Schwäble; Hanno Glimm; Ulrike Koehl; Carolin Preiss; Claudia Ball; Hans Martin; Gudrun Göhring; Kerstin Schwarzwaelder; Wolf-Karsten Hofmann; Kadin Karakaya; Sandrine Tchatchou; Rongxi Yang; Petra Reinecke; Klaus Kühlcke; Brigitte Schlegelberger; Adrian J Thrasher; Dieter Hoelzer; Reinhard Seger; Christof von Kalle; Manuel Grez
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease.
Nature medicine 2010;16(2):198-204.
2010: Thomas Burmeister; Nicola Gökbuget; Stefan Schwartz; Lars Fischer; Daniela Hubert; Annette Sindram; Dieter Hoelzer; Eckhard Thiel
Clinical features and prognostic implications of TCF3-PBX1 and ETV6-RUNX1 in adult acute lymphoblastic leukemia.
Haematologica 2010;95(2):241-6.
2010: Shuling Wu; Lars Fischer; Nicola Gökbuget; Stefan Schwartz; Thomas Burmeister; Michael Notter; Dieter Hoelzer; Hendrik Fuchs; Igor Wolfgang Blau; Wolf K Hofmann; Eckhard Thiel
Expression of interleukin 15 in primary adult acute lymphoblastic leukemia.
Cancer 2010;116(2):387-92.
2010: Gianni Capalbo; Thea Müller-Kuller; Ursula Dietrich; Dieter Hoelzer; Oliver G Ottmann; Urban J Scheuring
Inhibition of HIV-1 replication by small interfering RNAs directed against glioma pathogenesis related protein (GliPR) expression.
Retrovirology 2010;7():26.
2009: Monika Brüggemann; Heiko Trautmann; Dieter Hoelzer; Michael Kneba; Nicola Gökbuget; Thorsten Raff
Multidrug resistance-associated protein 4 (MRP4) gene polymorphisms and treatment response in adult acute lymphoblastic leukemia.
Blood 2009;114(26):5400-1; author reply 5401-2.
2009: Antonia Busse; Nicola Gökbuget; Jan M Siehl; Dieter Hoelzer; Stefan Schwartz; Anika Rietz; Eckhard Thiel; Ulrich Keilholz
Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome.
Annals of hematology 2009;88(12):1199-205.
2009: Dieter Hoelzer
Update on burkitt lymphoma and leukemia.
Clinical advances in hematology & oncology : H&O 2009;7(11):728-9.
2009: Claudia D Baldus; Julia Thibaut; Nicola Goekbuget; Andrea Stroux; Cornelia Schlee; Max Mossner; Thomas Burmeister; Stefan Schwartz; Clara D Bloomfield; Dieter Hoelzer; Eckhard Thiel; Wolf-Karsten Hofmann
Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia.
Haematologica 2009;94(10):1383-90.
2009: Jennifer L Kelly; Stephen R Toothaker; Lauren Ciminello; Dieter Hoelzer; Harald Holte; Ann S LaCasce; Graham Mead; Deborah Thomas; Gustaaf W van Imhoff; Brad S Kahl; Bruce D Cheson; Ian Trevor Magrath; Richard I Fisher; Jonathan W Friedberg
Outcomes of patients with Burkitt lymphoma older than age 40 treated with intensive chemotherapeutic regimens.
Clinical lymphoma & myeloma 2009;9(4):307-10.
2009: Thomas Burmeister; Claus Meyer; Stefan Schwartz; Julia Hofmann; Mara Molkentin; Eric Kowarz; Björn Schneider; Thorsten Raff; Richard Reinhardt; Nicola Gökbuget; Dieter Hoelzer; Eckhard Thiel; Rolf Marschalek
The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.
Blood 2009;113(17):4011-5.
2009: Olaf Hopfer; Martina Komor; Ina Sabine Koehler; Claudia Freitag; Matthias Schulze; Dieter Hoelzer; Eckhard Thiel; Wolf-Karsten Hofmann
Aberrant promotor methylation in MDS hematopoietic cells during in vitro lineage specific differentiation is differently associated with DNMT isoforms.
Leukemia research 2009;33(3):434-42.
2009: Lars Fischer; Nicola Gökbuget; Stefan Schwartz; Thomas Burmeister; Harald Rieder; Monika Brüggemann; Dieter Hoelzer; Eckhard Thiel
CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy.
Haematologica 2009;94(2):224-9.
2009: Dieter Hoelzer; Nicola Gökbuget
T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity?
Clinical lymphoma & myeloma 2009;9 Suppl 3():S214-21.
2008: Thomas Burmeister; Stefan Schwartz; Claus R Bartram; Nicola Gökbuget; Dieter Hoelzer; Eckhard Thiel
Patients' age and BCR-ABL frequency in adult B-precursor ALL: a retrospective analysis from the GMALL study group.
Blood 2008;112(3):918-9.
2008: Albert Oriol; Josep-Maria Ribera; Juan Bergua; Eduardo Giménez Mesa; Carlos Grande; Jordi Esteve; Salut Brunet; Maria-Jose Moreno; Lourdes Escoda; Jesus-Maria Hernandez-Rivas; Dieter Hoelzer
High-dose chemotherapy and immunotherapy in adult Burkitt lymphoma: comparison of results in human immunodeficiency virus-infected and noninfected patients.
Cancer 2008;113(1):117-25.
2008: U Baak; Nicola Gökbuget; Helmut Orawa; Stefan Schwartz; Dieter Hoelzer; Eckhard Thiel; Thomas Burmeister
Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group.
Leukemia 2008;22(6):1154-60.
2007: Richard R Furman; Dieter Hoelzer
Purine nucleoside phosphorylase inhibition as a novel therapeutic approach for B-cell lymphoid malignancies.
Seminars in oncology 2007;34(6 Suppl 5):S29-34.
2007: Thomas Burmeister; Stefan Schwartz; Almut Taubald; Edgar Jost; Thomas Lipp; Folker Schneller; Helmut Diedrich; Henrike Thomssen; Ulrich Mey; Jan Eucker; Harald Rieder; Nicola Gökbuget; Dieter Hoelzer; Eckhard Thiel
Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.
Haematologica 2007;92(12):1699-702.
2007: Gesine Bug; Konstantinos Anargyrou; Torsten Tonn; Heike Bialleck; Erhard Seifried; Dieter Hoelzer; Oliver G Ottmann
Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis.
Transfusion 2007;47(10):1843-50.
2007: Daniel Nowak; Simone Boehrer; Simone Hochmuth; Bettina Trepohl; Wencke Hofmann; Dieter Hoelzer; Wolf-Karsten Hofmann; Paris S Mitrou; Martin Ruthardt; Kai Uwe Chow
Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells.
Anti-cancer drugs 2007;18(9):981-95.
2007: Claudia D Baldus; Peter Martus; Thomas Burmeister; Stefan Schwartz; Nicola Gökbuget; Clara D Bloomfield; Dieter Hoelzer; Eckhard Thiel; Wolf-Karsten Hofmann
Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(24):3739-45.
2007: Heike Pfeifer; Barbara Wassmann; Anna Pavlova; Lydia Wunderle; Johannes Oldenburg; Anja Binckebanck; Thoralf Lange; Andreas Hochhaus; Silvia Wystub; Patrick Brück; Dieter Hoelzer; Oliver G Ottmann
Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).
Blood 2007;110(2):727-34.
2007: Patrick Brück; Sabine Mousset; A Bühme; Dieter Hoelzer; Johannes Atta
Nonsecretory primary plasma cell leukemia with good response to thalidomide-based treatment.
International journal of hematology 2007;86(1):66-8.
2007: Kai Uwe Chow; Daniel Nowak; Bettina Trepohl; Simone Hochmuth; Bernd Schneider; Dieter Hoelzer; Paris S Mitrou; Lothar Bergmann; Oliver G Ottmann; Simone Boehrer
The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines.
Leukemia & lymphoma 2007;48(7):1379-88.
2007: Marion G Ott; Reinhard Seger; Stefan Stein; Ulrich Siler; Dieter Hoelzer; Manuel Grez
Advances in the treatment of Chronic Granulomatous Disease by gene therapy.
Current gene therapy 2007;7(3):155-61.
2007: Oliver G Ottmann; Barbara Wassmann; Heike Pfeifer; Aristoteles Giagounidis; Matthias Stelljes; Ulrich Dührsen; Marc Schmalzing; Lydia Wunderle; Anja Binckebanck; Dieter Hoelzer
Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).
Cancer 2007;109(10):2068-76.
2007: Olaf Hopfer; Martina Komor; Ina Sabine Koehler; Matthias Schulze; Dieter Hoelzer; Eckhard Thiel; Wolf-Karsten Hofmann
DNA methylation profiling of myelodysplastic syndrome hematopoietic progenitor cells during in vitro lineage-specific differentiation.
Experimental hematology 2007;35(5):712-23.
2007: Gesine Bug; Kerstin Schwarz; Claudia Schoch; Manuela Kampfmann; Reinhard Henschler; Dieter Hoelzer; Oliver G Ottmann; Martin Ruthardt
Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia.
Haematologica 2007;92(4):542-5.
2007: Xiaomin Zheng; Anita Seshire; Brigitte Rüster; Gesine Bug; Tim Beissert; Elena Puccetti; Dieter Hoelzer; Reinhard Henschler; Martin Ruthardt
Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.
Haematologica 2007;92(3):323-31.
2007: Johannes Atta; Kai Uwe Chow; Eckhart Weidmann; Paris S Mitrou; Dieter Hoelzer; Hans Martin
Dexa-BEAM as salvage therapy in patients with primary refractory aggressive non-Hodgkin lymphoma.
Leukemia & lymphoma 2007;48(2):349-56.
2007: Thorsten Raff; Nicola Gökbuget; Silke Lüschen; Regina Reutzel; Matthias Ritgen; Sebastian Irmer; Sebastian Böttcher; Heinz-August Horst; Michael Kneba; Dieter Hoelzer; Monika Brüggemann
Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials.
Blood 2007;109(3):910-5.
2007: Thomas Burmeister; Stefan Schwartz; Michael Hummel; Dieter Hoelzer; Eckhard Thiel
No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms.
Retrovirology 2007;4():11.
2006: Thomas Burmeister; Nicola Gökbuget; Richard Reinhardt; Harald Rieder; Dieter Hoelzer; Stefan Schwartz
NUP214-ABL1 in adult T-ALL: the GMALL study group experience.
Blood 2006;108(10):3556-9.
2006: Dieter Hoelzer
Advances in the management of Ph-positive ALL.
Clinical advances in hematology & oncology : H&O 2006;4(11):804-5.
2006: Wolf-Karsten Hofmann; S Takeuchi; N Takeuchi; Eckhard Thiel; Dieter Hoelzer; H Phillip Koeffler
Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome.
Leukemia research 2006;30(11):1347-53.
2006: Susanne Saussele; K Adam; Andreas Hochhaus; marie bene; Thomas Büchner; A Burnett; G Finazzi; Christa Fonatsch; E Gluckman; Nicola Gökbuget; David Grimwade; Torsten Haferlach; M Hallek; Joerg Hasford; Dieter Hoelzer; P Ljungman; Dietger Niederwieser; Hubert Serve; B Simonsson; T J de Witte; Rüdiger Hehlmann
[Clinical research at the European LeukemiaNet].
Deutsche medizinische Wochenschrift (1946) 2006;131(43):2423-6.
2006: Claudia D Baldus; Thomas Burmeister; Peter Martus; Stefan Schwartz; Nicola Gökbuget; Clara D Bloomfield; Dieter Hoelzer; Eckhard Thiel; Wolf-Karsten Hofmann
High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(29):4714-20.
2006: Christian Hoffmann; Eva Wolf; Christoph Wyen; Gerd Fätkenheuer; Jan van Lunzen; Hans-Jürgen Stellbrink; Albrecht Stoehr; Andreas Plettenberg; Hans Jaeger; Richard Noppeney; Marcus Hentrich; Nicola Goekbuget; Dieter Hoelzer; Heinz-August Horst
AIDS-associated Burkitt or Burkitt-like lymphoma: short intensive polychemotherapy is feasible and effective.
Leukemia & lymphoma 2006;47(9):1872-80.
2006: Barbara Wassmann; Heike Pfeifer; Nicola Goekbuget; Dietrich W Beelen; Joachim Beck; Matthias Stelljes; Martin Bornhäuser; Albrecht Reichle; Jolanta B Perz; Rainer Haas; Arnold Ganser; Mathias Schmid; Lothar Kanz; Georg Lenz; Martin Kaufmann; Anja Binckebanck; Patrick Brück; Regina Reutzel; Harald Gschaidmeier; Stefan Schwartz; Dieter Hoelzer; Oliver G Ottmann
Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).
Blood 2006;108(5):1469-77.
2006: Andrew Lamb; Francis Giles; Lydia Wunderle; Kapil N Bhalla; Susan O'Brien; Barbara Wassmann; Chiaki Tanaka; Paul Manley; Patricia Rae; William Mietlowski; Kathy Bochinski; Andreas Hochhaus; James D Griffin; Dieter Hoelzer; Maher Albitar; Margaret Dugan; Jorge Cortes; Leila Alland; Oliver G Ottmann
Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL.
The New England journal of medicine 2006;354(24):2542-51.
2006: Susanne Saussele; Ute Berger; Carlo Aul; Thomas Büchner; Hartmut Döhner; Gerhard Ehninger; Arnold Ganser; Nicola Gökbuget; Dieter Hoelzer; Karl Uberla; Rüdiger Hehlmann
[Clinical research within the German competence net "acute and chronic leukemias"].
Medizinische Klinik (Munich, Germany : 1983) 2006;101(5):414-20.
2006: Simone Boehrer; Daniel Nowak; Elena Puccetti; Martin Ruthardt; Nicole Sattler; Bettina Trepohl; Bernd Schneider; Dieter Hoelzer; Paris S Mitrou; Kai Uwe Chow
Prostate-apoptosis-response-gene-4 increases sensitivity to TRAIL-induced apoptosis.
Leukemia research 2006;30(5):597-605.
2006: Noriko Koyama; Steffen Koschmieder; Sandhya Tyagi; Ignacio Portero-Robles; Jörg Chromic; Silke Myloch; Heike Nürnberger; Tanja Rossmanith; Wolf-Karsten Hofmann; Dieter Hoelzer; Oliver G Ottmann
Inhibition of phosphotyrosine phosphatase 1B causes resistance in BCR-ABL-positive leukemia cells to the ABL kinase inhibitor STI571.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):2025-31.
2006: Marion G Ott; Manfred Schmidt; Kerstin Schwarzwaelder; Stefan Stein; Ulrich Siler; Ulrike Koehl; Hanno Glimm; Klaus Kühlcke; Andrea Schilz; Hana Kunkel; Sonja Naundorf; Andrea Brinkmann; Annette Deichmann; Marlene Fischer; Claudia Ball; Ingo Pilz; Cynthia Dunbar; Yang Du; Nancy A Jenkins; Neal G Copeland; Ursula Lüthi; Moustapha Hassan; Adrian J Thrasher; Dieter Hoelzer; Christof von Kalle; Reinhard Seger; Manuel Grez
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.
Nature medicine 2006;12(4):401-9.
2006: Thomas Burmeister; Rolf Marschalek; B Schneider; Claus Meyer; Nicola Gökbuget; Stefan Schwartz; Dieter Hoelzer; Eckhard Thiel
Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations.
Leukemia 2006;20(3):451-7.
2006: Gerhard Heil; Dieter Hoelzer; MA Sanz; Klaus Lechner; L Noens; Jeff Szer; Arnold Ganser; James Matcham; J Renwick
Long-term survival data from a phase 3 study of Filgrastim as an adjunct to chemotherapy in adults with de novo acute myeloid leukemia.
Leukemia 2006;20(3):404-9.
2006: Monika Brüggemann; Thorsten Raff; Thomas Flohr; Nicola Gökbuget; Makoto Nakao; Jo Droese; Silke Lüschen; Christiane Pott; Matthias Ritgen; Urban J Scheuring; Heinz-August Horst; Eckhard Thiel; Dieter Hoelzer; Claus R Bartram; Michael Kneba
Clinical significance of minimal residual disease quantification in adult patients with standard-risk acute lymphoblastic leukemia.
Blood 2006;107(3):1116-23.
2006: Nicola Gökbuget; Dieter Hoelzer
Treatment of adult acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2006;():133-41.
2006: Nicola Gökbuget; Dieter Hoelzer
Novel antibody-based therapy for acute lymphoblastic leukaemia.
Best practice & research. Clinical haematology 2006;19(4):701-13.
2006: Simone Boehrer; Daniel Nowak; Dieter Hoelzer; Paris S Mitrou; Kai Uwe Chow
The molecular biology of TRAIL-mediated signaling and its potential therapeutic exploitation in hematopoietic malignancies.
Current medicinal chemistry 2006;13(18):2091-100.
2006: Simone Boehrer; Daniel Nowak; Dieter Hoelzer; Paris S Mitrou; Kai Uwe Chow
Novel agents aiming at specific molecular targets increase chemosensitivity and overcome chemoresistance in hematopoietic malignancies.
Current pharmaceutical design 2006;12(1):111-28.
2006: Kai Uwe Chow; Daniel Nowak; Soo-Zin Kim; Bernd Schneider; Martina Komor; Simone Boehrer; Paris S Mitrou; Dieter Hoelzer; Eckhart Weidmann; Wolf-Karsten Hofmann
In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling.
Pharmacological research : the official journal of the Italian Pharmacological Society 2006;53(1):49-61.
2005: Gesine Bug; Markus Ritter; Barbara Wassmann; Claudia Schoch; Thorsten Heinzel; Kerstin Schwarz; Annette Romanski; Oliver H Kramer; Manuela Kampfmann; Dieter Hoelzer; Andreas Neubauer; Martin Ruthardt; Oliver G Ottmann
Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia.
Cancer 2005;104(12):2717-25.
2005: Beate Gleissner; Nicola Goekbuget; Harald Rieder; Renate Arnold; Stefan Schwartz; Helmut Diedrich; Claudia Schoch; Barbara Heinze; Christa Fonatsch; Claus R Bartram; Dieter Hoelzer; Eckhard Thiel
CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL).
Blood 2005;106(13):4054-6.
2005: Gesine Bug; Johannes Atta; Stefan A Klein; Bernd Hertenstein; Lothar Bergmann; Simone Boehrer; Sabine Mousset; Dieter Hoelzer; Hans Martin
High-dose melphalan is an effective salvage therapy in acute myeloid leukaemia patients with refractory relapse and relapse after autologous stem cell transplantation.
Annals of hematology 2005;84(11):748-54.
2005: Sabine Mousset; Stella Hermann; Stefan A Klein; Heike Bialleck; Michaele Duchscherer; Barbara Bomke; Barbara Wassmann; Angelika Böhme; Dieter Hoelzer; Hans Martin
Prophylactic and interventional granulocyte transfusions in patients with haematological malignancies and life-threatening infections during neutropenia.
Annals of hematology 2005;84(11):734-41.
2005: Martina Komor; Saskia Güller; Claudia D Baldus; Sven de Vos; Dieter Hoelzer; Oliver G Ottmann; Wolf-Karsten Hofmann
Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation.
Stem cells (Dayton, Ohio) 2005;23(8):1154-69.
2005: Thomas Burmeister; Stefan Schwartz; Heinz-August Horst; Harald Rieder; Nicola Gökbuget; Dieter Hoelzer; Eckhard Thiel
Molecular heterogeneity of sporadic adult Burkitt-type leukemia/lymphoma as revealed by PCR and cytogenetics: correlation with morphology, immunology and clinical features.
Leukemia 2005;19(8):1391-8.
2005: Kerol Bartolović; Stefan Balabanov; Birgit Berner; Hans-Jörg Bühring; Martina Komor; Sven Becker; Dieter Hoelzer; Lothar Kanz; Wolf-Karsten Hofmann; Tim H Brümmendorf
Clonal heterogeneity in growth kinetics of CD34+CD38- human cord blood cells in vitro is correlated with gene expression pattern and telomere length.
Stem cells (Dayton, Ohio) 2005;23(7):946-57.
2005: Elena Puccetti; Xiaomin Zheng; Daria Brambilla; Anita Seshire; Tim Beissert; Simone Boehrer; Heike Nürnberger; Dieter Hoelzer; Oliver G Ottmann; Clara Nervi; Martin Ruthardt
The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.
Cancer research 2005;65(14):6080-8.
2005: Barbara Wassmann; Heike Pfeifer; Michael Stadler; Martin Bornhaüser; Gesine Bug; Urban J Scheuring; Patrick Brück; Matthias Stelljes; Rainer Schwerdtfeger; Nadezda Basara; Jolanta B Perz; Donald Bunjes; Georg Ledderose; Rolf Mahlberg; Anja Binckebanck; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).
Blood 2005;106(2):458-63.
2005: Mathias J Rummel; Salah-Eddin Al-Batran; Soo-Zin Kim; Manfred Welslau; Ralf Hecker; Dorothea Kofahl-Krause; Klaus-M Josten; Heinz Duerk; Andreas Rost; Michael Neise; Ulrich von Grünhagen; Kai Uwe Chow; Martin-Leo Hansmann; Dieter Hoelzer; Paris S Mitrou
Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(15):3383-9.
2005: Simone Boehrer; Daniel Nowak; Simone Hochmuth; Soo-Zin Kim; Bettina Trepohl; Amina Afkir; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Kai Uwe Chow
Daxx overexpression in T-lymphoblastic Jurkat cells enhances caspase-dependent death receptor- and drug-induced apoptosis in distinct ways.
Cellular signalling 2005;17(5):581-95.
2005: Gesine Bug; Hilal Gül; Kerstin Schwarz; Heike Pfeifer; Manuela Kampfmann; Xiaomin Zheng; Tim Beissert; Simone Boehrer; Dieter Hoelzer; Oliver G Ottmann; Martin Ruthardt
Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells.
Cancer research 2005;65(7):2537-41.
2005: Simone Boehrer; Daniel Nowak; Natasa Kukoc-Zivojnov; Simone Hochmuth; Soo-Zin Kim; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Kai Uwe Chow
Expression of Daxx sensitizes Jurkat T-cells to the apoptosis-inducing effect of chemotherapeutic agents.
Pharmacological research : the official journal of the Italian Pharmacological Society 2005;51(4):367-74.
2005: Annette Romanski; Gesine Bug; Sven Becker; Manuela Kampfmann; Erhard Seifried; Dieter Hoelzer; Oliver G Ottmann; Torsten Tonn
Mechanisms of resistance to natural killer cell-mediated cytotoxicity in acute lymphoblastic leukemia.
Experimental hematology 2005;33(3):344-52.
2005: Uta Arndt; Joachim Peter Kaltwasser; R Gottschalk; Dieter Hoelzer; Burkhard Möller
Correction of iron-deficient erythropoiesis in the treatment of anemia of chronic disease with recombinant human erythropoietin.
Annals of hematology 2005;84(3):159-66.
2005: Timo Wolf; Hans-Reinhard Brodt; Stephan Fichtlscherer; Kathleen Mantzsch; Dieter Hoelzer; Eilke B Helm; Paris S Mitrou; Kai Uwe Chow
Changing incidence and prognostic factors of survival in AIDS-related non-Hodgkin's lymphoma in the era of highly active antiretroviral therapy (HAART).
Leukemia & lymphoma 2005;46(2):207-15.
2004: Rüdiger Hehlmann; Ute Berger; Carlo Aul; Thomas Büchner; Hartmut Döhner; Gerhard Ehninger; Arnold Ganser; Nicola Gökbuget; Dieter Hoelzer; Karl Uberla
[The competence network "acute and chronic leukemias"].
Deutsche medizinische Wochenschrift (1946) 2004;129(49):2660-5.
2004: Patrick Brück; Barbara Wassmann; Elizabeth Ramos Lopez; Dieter Hoelzer; Oliver G Ottmann
Development of hygromas or severe edema during treatment with the tyrosine kinase inhibitor STI571 is not associated with platelet-derived growth factor receptor (PDGFR) gene polymorphisms.
Leukemia research 2004;28(11):1153-7.
2004: Simone Boehrer; Natasa Kukoc-Zivojnov; Daniel Nowak; Marion Bergmann; Christine Baum; Elena Puccetti; Eckhart Weidmann; Dieter Hoelzer; Paris S Mitrou; Kai Uwe Chow
Upon drug-induced apoptosis expression of prostate-apoptosis-response-gene-4 promotes cleavage of caspase-8, bid and mitochondrial release of cytochrome c.
Hematology (Amsterdam, Netherlands) 2004;9(5-6):425-31.
2004: Soo-Zin Kim; Kai Uwe Chow; Natasa Kukoc-Zivojnov; Simone Boehrer; Angela Brieger; Susanne Annette Steimle-Grauer; Lana Harder; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
Expression of ZAP-70 protein correlates with disease stage in chronic lymphocytic leukemia and is associated with, but not generally restricted to, non-mutated Ig VH status.
Leukemia & lymphoma 2004;45(10):2037-45.
2004: Marion Bergmann; Natasa Kukoc-Zivojnov; Kai Uwe Chow; Bettina Trepohl; Dieter Hoelzer; Eckhart Weidmann; Paris S Mitrou; Simone Boehrer
Prostate apoptosis response gene-4 sensitizes neoplastic lymphocytes to CD95-induced apoptosis.
Annals of hematology 2004;83(10):646-53.
2004: Ulrich Mahlknecht; Jutta Will; Audrey Varin; Dieter Hoelzer; Georges Herbein
Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(6):3979-90.
2004: Wolf-Karsten Hofmann; G Heil; C Zander; S Wiebe; Oliver G Ottmann; Lothar Bergmann; K Hoeffken; JT Fischer; A Knuth; K Kolbe; H J Schmoll; W Langer; M Westerhausen; C B Koelbel; Dieter Hoelzer; Arnold Ganser
Intensive chemotherapy with idarubicin, cytarabine, etoposide, and G-CSF priming in patients with advanced myelodysplastic syndrome and high-risk acute myeloid leukemia.
Annals of hematology 2004;83(8):498-503.
2004: Michael Kiehl; Ludwig Kraut; Rainer Schwerdtfeger; Bernd Hertenstein; Mats Remberger; Nicolaus Kroeger; Mathias Stelljes; Martin Bornhaeuser; Hans Martin; Christoph Scheid; Arnold Ganser; Axel R Zander; Joachim Kienast; Gerhard Ehninger; Dieter Hoelzer; Volker Diehl; Axel A Fauser; Olle Ringden
Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(14):2816-25.
2004: Simone Boehrer; Angela Brieger; Simone Schaaf; Natasa Kukoc-Zivojnov; Daniel Nowak; Martin Ruthardt; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Kai Uwe Chow
In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis.
Leukemia & lymphoma 2004;45(7):1445-51.
2004: Daniel Nowak; Simone Boehrer; Angela Brieger; Soo-Zin Kim; Simone Schaaf; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Kai Uwe Chow
Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus.
Leukemia & lymphoma 2004;45(7):1429-36.
2004: Natasa Kukoc-Zivojnov; Elena Puccetti; Kai Uwe Chow; Marion Bergmann; Martin Ruthardt; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Simone Boehrer
Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells.
Experimental hematology 2004;32(7):649-56.
2004: Angela Brieger; Simone Boehrer; Simone Schaaf; Daniel Nowak; Martin Ruthardt; Soo-Zin Kim; Peter Atadja; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Kai Uwe Chow
In bcr-abl-positive myeloid cells resistant to conventional chemotherapeutic agents, expression of Par-4 increases sensitivity to imatinib (STI571) and histone deacetylase-inhibitors.
Biochemical pharmacology 2004;68(1):85-93.
2004: Gerhard Heil; Jürgen Krauter; A Raghavachar; Lothar Bergmann; Dieter Hoelzer; W Fiedler; M Lübbert; L Noens; G Schlimok; Renate Arnold; Holger Kirchner; Arnold Ganser
Risk-adapted induction and consolidation therapy in adults with de novo AML aged
Annals of hematology 2004;83(6):336-44.

2004: James O Armitage; Kensei Tobinai; Dieter Hoelzer; Mathias J Rummel
Treatment of indolent non-Hodgkin's lymphoma with cladribine as single-agent therapy and in combination with mitoxantrone.
International journal of hematology 2004;79(4):311-21.
2004: Xiaomin Zheng; Tim Beissert; Natasa Kukoc-Zivojnov; Elena Puccetti; Joachim Altschmied; Corinna Strolz; Simone Boehrer; Hilal Gul; Orinta Schneider; Oliver G Ottmann; Dieter Hoelzer; Reinhard Henschler; Martin Ruthardt
Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.
Blood 2004;103(9):3535-43.
2004: Wolf-Karsten Hofmann; Martina Komor; Dieter Hoelzer; Oliver G Ottmann
Mechanisms of resistance to STI571 (Imatinib) in Philadelphia-chromosome positive acute lymphoblastic leukemia.
Leukemia & lymphoma 2004;45(4):655-60.
2004: Annette Romanski; Biserka Bacic; Gesine Bug; Heike Pfeifer; Hilal Gul; Stacy W Remiszewski; Dieter Hoelzer; Peter Atadja; Martin Ruthardt; Oliver G Ottmann
Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.
Haematologica 2004;89(4):419-26.
2004: Rüdiger Hehlmann; Ute Berger; Carlo Aul; Thomas Büchner; Hartmut Döhner; Gerhard Ehninger; Arnold Ganser; Dieter Hoelzer; Nicola Gökbuget; Karl Uberla
[Clinical research in the "acute and chronic leukemias"competence network ].
Der Internist 2004;45(4):384-92.
2004: Monika Brüggemann; V H J van der Velden; Thorsten Raff; Jo Droese; Matthias Ritgen; Christiane Pott; A J M Wijkhuijs; Nicola Gökbuget; Dieter Hoelzer; Elisabeth R van Wering; Jacques J M van Dongen; Michael Kneba
Rearranged T-cell receptor beta genes represent powerful targets for quantification of minimal residual disease in childhood and adult T-cell acute lymphoblastic leukemia.
Leukemia 2004;18(4):709-19.
2004: Nicola Gökbuget; Dieter Hoelzer
Treatment with monoclonal antibodies in acute lymphoblastic leukemia: current knowledge and future prospects.
Annals of hematology 2004;83(4):201-5.
2004: Noriko Koyama; Dieter Hoelzer; Oliver G Ottmann
Regulation of human IL-18 gene expression: interaction of PU.1 with GC-box binding protein is involved in human IL-18 expression in myeloid cells.
European journal of immunology 2004;34(3):817-26.
2004: Barbara Wassmann; Heike Pfeifer; Urban J Scheuring; Anja Binckebanck; Nicola Gökbuget; Johannes Atta; Patrick Brück; Harald Rieder; Claudia Schoch; Lothar Leimer; Rainer Schwerdtfeger; Gerhard Ehninger; Thomas Lipp; Jolanta B Perz; Matthias Stelljes; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Early prediction of response in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib.
Blood 2004;103(4):1495-8.
2004: Kerol Bartolovic; Stefan Balabanov; Ulrike Hartmann; Martina Komor; Andreas M Boehmler; Hans-Jörg Bühring; Robert Möhle; Dieter Hoelzer; Lothar Kanz; Wolf-Karsten Hofmann; Tim H Brümmendorf
Inhibitory effect of imatinib on normal progenitor cells in vitro.
Blood 2004;103(2):523-9.
2004: Simone Boehrer; Daniel Nowak; Simone Schaaf; Marion Bergmann; Angela Brieger; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann; Kai Uwe Chow
In malignant myeloid cells expression of Daxx downregulates expression of p53 and of the inhibitors of apoptosis proteins.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(6):513-8.
2004: Nicola Gökbuget; Renato Bassan; Adriaan Dekker; Hervé Dombret; Robin Foà; Norbert Ifrah; Tibor J Kovacsovics; Boris Labar; Franco Mandelli; Giovanna Meloni; Joseph Maria Ribera; Bengt Smedmyr; Jean-Paul Vernant; Jan Walewski; Rein Willemze; Dieter Hoelzer
Developing a European network for adult ALL.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5 Suppl 3():S46-52.
2004: Nicola Gökbuget; R Raff; M Brügge-Mann; T Flohr; Urban J Scheuring; Heike Pfeifer; Claus R Bartram; Michael Kneba; Dieter Hoelzer
Risk/MRD adapted GMALL trials in adult ALL.
Annals of hematology 2004;83 Suppl 1():S129-31.
2004: Mathias J Rummel; Sven de Vos; Dieter Hoelzer; H Phillip Koeffler; Wolf-Karsten Hofmann
Altered apoptosis pathways in mantle cell lymphoma.
Leukemia & lymphoma 2004;45(1):49-54.
2004: Wolf-Karsten Hofmann; Michael Lübbert; Dieter Hoelzer; H Phillip Koeffler
Myelodysplastic syndromes.
The hematology journal : the official journal of the European Haematology Association / EHA 2004;5(1):1-8.
2003: Oliver Rosen; H J Müller; Nicola Gökbuget; W Langer; N Peter; Stefan Schwartz; D Hähling; Frank Hartmann; Thomas Ittel; R Mück; Frank Rothmann; Renate Arnold; J Boos; Dieter Hoelzer
Pegylated asparaginase in combination with high-dose methotrexate for consolidation in adult acute lymphoblastic leukaemia in first remission: a pilot study.
British journal of haematology 2003;123(5):836-41.
2003: Ulrich Mahlknecht; Dieter Hoelzer
[Epigenetic regulators as novel therapeutic targets in hematology/oncology].
Deutsche medizinische Wochenschrift (1946) 2003;128(46):2423-6.
2003: Barbara Wassmann; Nicola Gökbuget; Urban J Scheuring; Anja Binckebanck; Regina Reutzel; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
A randomized multicenter open label phase II study to determine the safety and efficacy of induction therapy with imatinib (Glivec, formerly STI571) in comparison with standard induction chemotherapy in elderly (>55 years) patients with Philadelphia chromosome-positive (Ph+/BCR-ABL+) acute lymphoblastic leukemia (ALL) (CSTI571ADE 10).
Annals of hematology 2003;82(11):716-20.
2003: Harald Rieder; Ina Bachmann; Sylke Busch; Stefan Schwartz; Barbara Reckzeh; Dieter Hoelzer
Cell lineage assignment of cytogenetic findings in acute lymphoblastic leukemia using combined immunomagnetic cell separation and chromosome preparation.
Haematologica 2003;88(11):1317-20.
2003: Heike Pfeifer; Barbara Wassmann; Wolf-Karsten Hofmann; Martina Komor; Urban J Scheuring; Patrick Brück; Anja Binckebanck; Eberhard Schleyer; Nicola Gökbuget; Thomas Wolff; Michael Lübbert; Lothar Leimer; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4674-81.
2003: Tim Beissert; Elena Puccetti; Andrea Bianchini; Saskia Güller; Simone Boehrer; Dieter Hoelzer; Oliver G Ottmann; Clara Nervi; Martin Ruthardt
Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571.
Blood 2003;102(8):2985-93.
2003: Elena Puccetti; Tim Beissert; Saskia Güller; Jun E Li; Dieter Hoelzer; Oliver G Ottmann; Martin Ruthardt
Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.
Oncogene 2003;22(44):6900-8.
2003: Barbara Wassmann; Urban J Scheuring; Heike Pfeifer; Anja Binckebanck; A Käbisch; M Lübbert; Lothar Leimer; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Efficacy and safety of imatinib mesylate (Glivec) in combination with interferon-alpha (IFN-alpha) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).
Leukemia 2003;17(10):1919-24.
2003: Ulrich Mahlknecht; Jason Chesney; Dieter Hoelzer; Richard Bucala
Cloning and chromosomal characterization of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 gene (PFKFB3, iPFK2).
International journal of oncology 2003;23(4):883-91.
2003: Urban J Scheuring; Heike Pfeifer; Barbara Wassmann; Patrick Brück; B Gehrke; Eduard K Petershofen; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Serial minimal residual disease (MRD) analysis as a predictor of response duration in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) during imatinib treatment.
Leukemia 2003;17(9):1700-6.
2003: Urban J Scheuring; Heike Pfeifer; Barbara Wassmann; Patrick Brück; Dieter Hoelzer; Oliver G Ottmann
Methodologic and biological variability of quantitative real-time polymerase chain reaction analysis of Bcr-Abl expression in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Haematologica 2003;88(9):1074-6.
2003: Kai Uwe Chow; Daniel Nowak; Simone Boehrer; Martin Ruthardt; Andrea Knau; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation.
Biochemical pharmacology 2003;66(5):711-24.
2003: Wolf-Karsten Hofmann; Martina Komor; Barbara Wassmann; Letetia C Jones; Harald Gschaidmeier; Dieter Hoelzer; H Phillip Koeffler; Oliver G Ottmann
Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia.
Blood 2003;102(2):659-61.
2003: Nicola Gökbuget; Dieter Hoelzer
Non-myeloablative conditioning before allogeneic stem cell transplantation in adult acute lymphoblastic leukemia.
Haematologica 2003;88(5):484-6.
2003: Barbara Wassmann; Urban J Scheuring; Christian Thiede; Heike Pfeifer; Martin Bornhäuser; F Griesinger; Andreas Hochhaus; Eberhard Schleyer; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Stable molecular remission induced by imatinib mesylate (STI571) in a patient with CML lymphoid blast crisis relapsing after allogeneic stem cell transplantation.
Bone marrow transplantation 2003;31(7):611-4.
2003: Soo-Zin Kim; Thomas M Zollner; Daniela K Schui; Kai Uwe Chow; Wolfram Sterry; Susanne Kriener; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
CD4+ CD56+ neoplasia: clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis X.
Leukemia & lymphoma 2003;44(2):281-9.
2003: Stefan A Klein; Susanne Karsten; Brigitte Rüster; Christian Klebba; Martine Pape; Oliver G Ottmann; Dieter Hoelzer; W Kurt Roth
Comparison of TaqMan real-time PCR and p24 Elisa for quantification of in vitro HIV-1 replication.
Journal of virological methods 2003;107(2):169-75.
2003: Kai Uwe Chow; Simone Boehrer; Simone Napieralski; Daniel Nowak; Andrea Knau; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
In AML cell lines Ara-C combined with purine analogues is able to exert synergistic as well as antagonistic effects on proliferation, apoptosis and disruption of mitochondrial membrane potential.
Leukemia & lymphoma 2003;44(1):165-73.
2003: Urban J Scheuring; Heike Pfeifer; Barbara Wassmann; Patrick Bruck; Johannes Atta; Eduard K Petershofen; Brigitte Gehrke; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl-positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571).
Blood 2003;101(1):85-90.
2002: Marcella Grundmann-Kollmann; Hans Martin; Ralf Ludwig; Stefan Klein; Wolf-Henning Boehncke; Dieter Hoelzer; Roland Kaufmann; Maurizio Podda
Narrowband UV-B phototherapy in the treatment of cutaneous graft versus host disease.
Transplantation 2002;74(11):1631-4.
2002: Birgit Assmus; Volker Schächinger; Claudius Teupe; Martina B Britten; Ralf Lehmann; Natascha Döbert; Frank Grünwald; Alexandra Aicher; Carmen Urbich; Hans Martin; Dieter Hoelzer; Stefanie Dimmeler; Andreas M Zeiher
Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI).
Circulation 2002;106(24):3009-17.
2002: Dieter Hoelzer; Nicola Gökbuget
Treatment of lymphoblastic lymphoma in adults.
Best practice & research. Clinical haematology 2002;15(4):713-28.
2002: Nicola Gökbuget; Michael Kneba; Thorsten Raff; Monika Bruggemann; Urban J Scheuring; Regina Reutzel; Dieter Hoelzer
Risk-adapted treatment according to minimal residual disease in adult ALL.
Best practice & research. Clinical haematology 2002;15(4):639-52.
2002: Simone Boehrer; Daniela K Schui; Kai Uwe Chow; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
Cytotoxic activity of T- and NK-cell lymphoma cells is not dependent on a mature cytotoxic phenotype.
Leukemia & lymphoma 2002;43(12):2363-8.
2002: Elena Puccetti; Darja Obradovic; Tim Beissert; Andrea Bianchini; Birgit Washburn; Ferdinando Chiaradonna; Simone Boehrer; Dieter Hoelzer; Oliver G Ottmann; Pier Giuseppe Pelicci; Clara Nervi; Martin Ruthardt
AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor.
Cancer research 2002;62(23):7050-8.
2002: Renate Arnold; Gero Massenkeil; Martin Bornhäuser; Gerhard Ehninger; Dietrich W Beelen; Axel A Fauser; Ute Hegenbart; Bernd Hertenstein; A D Ho; Wolfgang Knauf; H J Kolb; K Kolbe; Herbert G Sayer; Rainer Schwerdtfeger; Hannes Wandt; Dieter Hoelzer
Nonmyeloablative stem cell transplantation in adults with high-risk ALL may be effective in early but not in advanced disease.
Leukemia 2002;16(12):2423-8.
2002: Barbara Wassmann; Heike Pfeifer; Urban J Scheuring; Stefan A Klein; Nicola Gökbuget; Anja Binckebanck; Hans Martin; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Therapy with imatinib mesylate (Glivec) preceding allogeneic stem cell transplantation (SCT) in relapsed or refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL).
Leukemia 2002;16(12):2358-65.
2002: Wolf-Karsten Hofmann; Sven de Vos; Martina Komor; Dieter Hoelzer; William Wachsman; H Phillip Koeffler
Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow.
Blood 2002;100(10):3553-60.
2002: Burkhard Möller; T T Nguyen; Uta Kessler; Joachim Peter Kaltwasser; Dieter Hoelzer; Oliver G Ottmann
Interleukin-10 expression: is there a neglected contribution of CD8+ T cells in rheumatoid arthritis joints?
Clinical and experimental rheumatology 2002;20(6):813-22.
2002: Dieter Hoelzer; Renate Arnold; Claus R Bartram; Angelika Böhme; M Freund; Arnold Ganser; Michael Kneba; Thomas Lipp; Wolf-Dieter Ludwig; Georg Maschmeyer; Harald Rieder; Eckhard Thiel; D Messerer; A Weiss; Nicola Gökbuget
[Acute lymphatic leukemia in the adult. Diagnosis, risk groups and therapy].
Der Internist 2002;43(10):1212-6, 1219-22, 1224-7.
2002: Dieter Hoelzer; Nicola Gökbuget; Oliver G Ottmann
Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Seminars in hematology 2002;39(4 Suppl 3):32-7.
2002: Wolf-Karsten Hofmann; Gernot Seipelt; S Langenhan; Regina Reutzel; D Schott; O Schoeffski; Hans-Jochen Illiger; Frank Hartmann; Leopold Balleisen; Astrid Franke; Friedrich Fiedler; Christoph Huber; Herbert Rasche; Lothar Bergmann; Arnold Ganser; Christiane Pott; Rita Pasold; C Rudolph; Oliver G Ottmann; Nicola Gökbuget; Dieter Hoelzer
Prospective randomized trial to evaluate two delayed granulocyte colony stimulating factor administration schedules after high-dose cytarabine therapy in adult patients with acute lymphoblastic leukemia.
Annals of hematology 2002;81(10):570-4.
2002: Gesine Bug; Tanja Rossmanith; Reinhard Henschler; Leoni A Kunz-Schughart; B Schröder; Manuela Kampfmann; M Kreutz; Dieter Hoelzer; Oliver G Ottmann
Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells.
Journal of leukocyte biology 2002;72(4):837-45.
2002: Oliver G Ottmann; Brian J Druker; Charles L Sawyers; John M Goldman; Josy Reiffers; Richard T Silver; Sante Tura; Thomas Fischer; Michael W N Deininger; Charles Alan Schiffer; Michele Baccarani; Alois Gratwohl; Andreas Hochhaus; Dieter Hoelzer; Sofia Fernandes-Reese; Insa Gathmann; Renaud Capdeville; Stephen G O'Brien
A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias.
Blood 2002;100(6):1965-71.
2002: Simone Boehrer; Kai Uwe Chow; Martin Ruthardt; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
Expression and function of prostate-apoptosis-response-gene-4 in lymphatic cells.
Leukemia & lymphoma 2002;43(9):1737-41.
2002: Burkhard Möller; Natasa Kukoc-Zivojnov; Noriko Koyama; S Grapenthin; Uta Kessler; Stefan A Klein; Uwe Kalina; Joachim Peter Kaltwasser; Dieter Hoelzer; Oliver G Ottmann
Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2002;51(9):457-63.
2002: Uwe Kalina; Noriko Koyama; Tomoko Hosoda; Heike Nuernberger; Kazuto Sato; Dieter Hoelzer; Frank Herweck; Tobias Manigold; Manfred V Singer; Siegbert Rossol; Ulrich Böcker
Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region.
European journal of immunology 2002;32(9):2635-43.
2002: Mathias J Rummel; Kai Uwe Chow; T Karakas; E Jäger; J Mezger; U von Grünhagen; K P Schalk; O Burkhard; Martin-Leo Hansmann; H Ritzel; Lothar Bergmann; Dieter Hoelzer; Paris S Mitrou
Reduced-dose cladribine (2-CdA) plus mitoxantrone is effective in the treatment of mantle-cell and low-grade non-Hodgkin's lymphoma.
European journal of cancer (Oxford, England : 1990) 2002;38(13):1739-46.
2002: Marion G Ott; Heike Merget-Millitzer; Oliver G Ottmann; Hans Martin; Nicole Brüggenolte; Heike Bialek; Reinhard Seger; Johann Peter Hossle; Dieter Hoelzer; Manuel Grez
Mobilization and transduction of CD34(+) peripheral blood stem cells in patients with X-linked chronic granulomatous disease.
Journal of hematotherapy & stem cell research 2002;11(4):683-94.
2002: Eckhart Weidmann; Soo-Zin Kim; Andreas Rost; H Schuppert; Gernot Seipelt; Dieter Hoelzer; Paris S Mitrou
Bendamustine is effective in relapsed or refractory aggressive non-Hodgkin's lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2002;13(8):1285-9.
2002: Mathias J Rummel; Paris S Mitrou; Dieter Hoelzer
Bendamustine in the treatment of non-Hodgkin's lymphoma: results and future perspectives.
Seminars in oncology 2002;29(4 Suppl 13):27-32.
2002: Mathias J Rummel; Kai Uwe Chow; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
In vitro studies with bendamustine: enhanced activity in combination with rituximab.
Seminars in oncology 2002;29(4 Suppl 13):12-4.
2002: Thomas S Dobmeyer; Rita Dobmeyer; Daniela Wesch; Eilke B Helm; Dieter Hoelzer; Dieter Kabelitz
Reciprocal alterations of Th1/Th2 function in gammadelta T-cell subsets of human immunodeficiency virus-1-infected patients.
British journal of haematology 2002;118(1):282-8.
2002: Dieter Hoelzer; Nicola Gökbuget; Werner Digel; Thomas Faak; Michael Kneba; Regina Reutzel; Joanna Romejko-Jarosinska; Jacek Zwolinski; Jan Walewski
Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia.
Blood 2002;99(12):4379-85.
2002: Nicola Gökbuget; Dieter Hoelzer
Recent approaches in acute lymphoblastic leukemia in adults.
Reviews in clinical and experimental hematology 2002;6(2):114-41; discussion 200-2.
2002: Burkhard Möller; Natasa Kukoc-Zivojnov; Stella Okamgba; Uta Kessler; Elena Puccetti; Oliver G Ottmann; Joachim Peter Kaltwasser; Dieter Hoelzer; Martin Ruthardt
Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.
Rheumatology international 2002;22(2):60-7.
2002: Katharina Schroeder; Steffen Koschmieder; Oliver G Ottmann; Dieter Hoelzer; Hansjörg Hauser; Peter P Mueller
Coordination of cell growth in cocultures by a genetic proliferation control system.
Biotechnology and bioengineering 2002;78(3):346-52.
2002: T Karakas; CC Miething; U Maurer; Eckhart Weidmann; H Ackermann; Dieter Hoelzer; Lothar Bergmann
The coexpression of the apoptosis-related genes bcl-2 and wt1 in predicting survival in adult acute myeloid leukemia.
Leukemia 2002;16(5):846-54.
2002: Nicola Gökbuget; Dieter Hoelzer
The role of high-dose cytarabine in induction therapy for adult ALL.
Leukemia research 2002;26(5):473-6.
2002: Ulrich Mahlknecht; Susanne Schnittger; Jutta Will; Nurten Cicek; Dieter Hoelzer
Chromosomal organization and localization of the human histone deacetylase 9 gene (HDAC9).
Biochemical and biophysical research communications 2002;293(1):182-91.
2002: Noriko Koyama; Steffen Koschmieder; Sandhya Tyagi; Heike Nürnberger; Sandra Wagner; Ulrich Böcker; Dieter Hoelzer; Oliver Gerhard Ottmann; Uwe Kalina
Differential effects of histone deacetylase inhibitors on interleukin-18 gene expression in myeloid cells.
Biochemical and biophysical research communications 2002;292(4):937-43.
2002: Wolf-Karsten Hofmann; Seisho Takeuchi; Malka A Frantzen; Dieter Hoelzer; H Phillip Koeffler
Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.
Experimental hematology 2002;30(4):318-23.
2002: Daniela K Schui; Lisa Singh; Bernd Schneider; Andrea Knau; Dieter Hoelzer; Eckhart Weidmann
Inhibiting effects on the induction of cytotoxic T lymphocytes by dendritic cells pulsed with lysates from acute myeloid leukemia blasts.
Leukemia research 2002;26(4):383-9.
2002: Simone Boehrer; Kai Uwe Chow; Florian Beske; Natasa Kukoc-Zivojnov; Elena Puccetti; Martin Ruthardt; Christine Baum; Vivek M Rangnekar; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation.
Cancer research 2002;62(6):1768-75.
2002: Stefan A Klein; Stella Hermann; Johann Wolfgang Dietrich; Dieter Hoelzer; Hans Martin
Transplantation-related toxicity and acute intestinal graft-versus-host disease after conditioning regimens intensified with Rhenium 188-labeled anti-CD66 monoclonal antibodies.
Blood 2002;99(6):2270-1.
2002: Steffen Koschmieder; Florian Fauth; Susanne Kriener; Dieter Hoelzer; Gernot Seipelt
Effective treatment of simultaneous small cell lung cancer and B-cell lymphoma.
Leukemia & lymphoma 2002;43(3):645-7.
2002: Wolf-Karsten Hofmann; Letetia C Jones; Nathan Lemp; Sven de Vos; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann; H Phillip Koeffler
Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.
Blood 2002;99(5):1860-2.
2002: Beate Gleissner; Nicola Gökbuget; Claus R Bartram; Bart Janssen; Harald Rieder; Johannes W G Janssen; Christa Fonatsch; Axel Heyll; Dimitris Voliotis; Joachim Beck; Thomas Lipp; Gerd Munzert; Jürgen Maurer; Dieter Hoelzer; Eckhard Thiel
Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis.
Blood 2002;99(5):1536-43.
2002: Adrian F Gombart; Wolf-Karsten Hofmann; Seiji Kawano; Seisho Takeuchi; Utz Krug; Scott H Kwok; Renee J Larsen; Hiroya Asou; Carl W Miller; Dieter Hoelzer; H Phillip Koeffler
Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.
Blood 2002;99(4):1332-40.
2002: Wolf-Karsten Hofmann; Sven de Vos; David Elashoff; Harald Gschaidmeier; Dieter Hoelzer; H Phillip Koeffler; Oliver G Ottmann
Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study.
Lancet 2002;359(9305):481-6.
2002: Kai Uwe Chow; Simone Boehrer; Jörg Bojunga; Manuela Stieler; Mathias J Rummel; Florian Fauth; Bernd Schneider; Hans Martin; Dieter Hoelzer; Eckhart Weidmann; Paris S Mitrou
Induction of apoptosis by cladribine (2-CdA), gemcitabine and other chemotherapeutic drugs on CD34+/CD38+ and CD34+/CD38- hematopoietic progenitor cells: selective effects of doxorubicin and 2-CdA with protection of immature cells.
Leukemia & lymphoma 2002;43(2):377-84.
2002: Gernot Seipelt; Ulrich Germing; Steffen Koschmieder; Angelika Böhme; Carlo Aul; Dieter Hoelzer
Secondary acute myeloid leukaemia with monosomy 7 in identical adult twins.
British journal of haematology 2002;116(2):338-40.
2002: Oliver G Ottmann; Barbara Wassmann; Dieter Hoelzer
[Therapy of Philadelphia chromosome positive acute lymphatic leukemia (Ph+ ALL) with an inhibitor of abl-tyrosine kinase (Glivec)].
Medizinische Klinik (Munich, Germany : 1983) 2002;97 Suppl 1():16-21.
2002: Oliver G Ottmann; Barbara Wassmann; Dieter Hoelzer
Imatinib for relapsed BCR/ABL positive leukemias.
Annals of hematology 2002;81 Suppl 2():S36-7.
2002: Dieter Hoelzer; Nicola Gökbuget; Oliver G Ottmann; Ching-Hon Pui; Mary Relling; Frederick R Appelbaum; Jacques J M van Dongen; Tomasz Szczepański
Acute lymphoblastic leukemia.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2002;():162-92.
2002: Oliver G Ottmann; Dieter Hoelzer
The ABL tyrosine kinase inhibitor STI571 (Glivec) in Philadelphia positive acute lymphoblastic leukemia - promises, pitfalls and possibilities.
The hematology journal : the official journal of the European Haematology Association / EHA 2002;3(1):2-6.
2002: Burkhard Möller; Uta Kessler; Stefan Rehart; Uwe Kalina; Oliver G Ottmann; Joachim Peter Kaltwasser; Dieter Hoelzer; Natasa Kukoc-Zivojnov
Expression of interleukin-18 receptor in fibroblast-like synoviocytes.
Arthritis research 2002;4(2):139-44.
2002: Kai Uwe Chow; Wolf Daniel Sommerlad; Simone Boehrer; Bernd Schneider; Gernot Seipelt; Mathias J Rummel; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.
Haematologica 2002;87(1):33-43.
2001: Stefan A Klein; Hans Martin; Dagmar Schreiber-Dietrich; Stella Hermann; Wolfgang F Caspary; Dieter Hoelzer; Christoph F Dietrich
A new approach to evaluating intestinal acute graft-versus-host disease by transabdominal sonography and colour Doppler imaging.
British journal of haematology 2001;115(4):929-34.
2001: Beate Gleissner; Harald Rieder; Eckhard Thiel; Christa Fonatsch; L A Janssen; Barbara Heinze; Johannes W G Janssen; Claudia Schoch; Nicola Goekbuget; Jürgen Maurer; Dieter Hoelzer; Claus R Bartram
Prospective BCR-ABL analysis by polymerase chain reaction (RT-PCR) in adult acute B-lineage lymphoblastic leukemia: reliability of RT-nested-PCR and comparison to cytogenetic data.
Leukemia 2001;15(12):1834-40.
2001: Barbara Wassmann; Stefan A Klein; Urban J Scheuring; Heike Pfeifer; Hans Martin; Harald Gschaidmeier; Dieter Hoelzer; Oliver G Ottmann
Hematologic and cytogenetic remission by STI571 (Glivec) in a patient relapsing with accelerated phase CML after second allogeneic stem cell transplantation.
Bone marrow transplantation 2001;28(7):721-4.
2001: Wolf-Karsten Hofmann; Seisho Takeuchi; D Xie; Carl W Miller; Dieter Hoelzer; H Phillip Koeffler
Frequent loss of heterozygosity in the region of D1S450 at 1p36.2 in myelodysplastic syndromes.
Leukemia research 2001;25(10):855-8.
2001: Steffen Koschmieder; Wolf-Karsten Hofmann; J Kunert; Sandra Wagner; K Ballas; Gernot Seipelt; Dieter Hoelzer; Oliver G Ottmann; Uwe Kalina
TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.
Leukemia 2001;15(6):942-9.
2001: Kai Uwe Chow; Simone Boehrer; K Geduldig; A Krapohl; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
In vitro induction of apoptosis of neoplastic cells in low-grade non-Hodgkin's lymphomas using combinations of established cytotoxic drugs with bendamustine.
Haematologica 2001;86(5):485-93.
2001: Stella Hermann; Stefan A Klein; Volkmar Jacobi; Axel Thalhammer; Heike Bialleck; M Duchscherer; Barbara Wassmann; Dieter Hoelzer; Hans Martin
Older patients with high-risk fungal infections can be successfully allografted using non-myeloablative conditioning in combination with intensified supportive care regimens.
British journal of haematology 2001;113(2):446-54.
2001: Uwe Kalina; Steffen Koschmieder; Wolf-Karsten Hofmann; Sandra Wagner; D Kauschat; Dieter Hoelzer; Oliver G Ottmann
Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.
Experimental hematology 2001;29(5):602-8.
2001: Eckhart Weidmann; Simone Boehrer; Kai Uwe Chow; Knut Engels; Lana Harder; Thomas Hinz; Ottmar Janssen; Susanne Kriener; Mathias J Rummel; Reiner Siebert; Dieter Kabelitz; Martin-Leo Hansmann; Dieter Hoelzer; Paris S Mitrou
Treatment of aggressive, or progressing indolent peripheral T- and NK-cell neoplasias by combination of fludarabine, cyclophosphamide and doxorubicine.
Onkologie 2001;24(2):162-4.
2001: Wolf-Karsten Hofmann; Carl W Miller; Kunihiro Tsukasaki; Sigal Tavor; Takayuki Ikezoe; Dieter Hoelzer; Seisho Takeuchi; H Phillip Koeffler
Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias.
Leukemia research 2001;25(4):333-8.
2001: Kai Uwe Chow; Paris S Mitrou; K Geduldig; Eilke B Helm; Dieter Hoelzer; Hans-Reinhard Brodt
Changing incidence and survival in patients with aids-related non-Hodgkin's lymphomas in the era of highly active antiretroviral therapy (HAART).
Leukemia & lymphoma 2001;41(1-2):105-16.
2001: Gernot Seipelt; Angelika Böhme; Steffen Koschmieder; Dieter Hoelzer
Effective treatment with rituximab in a patient with refractory prolymphocytoid transformed B-chronic lymphocytic leukemia and Evans syndrome.
Annals of hematology 2001;80(3):170-3.
2001: Burkhard Möller; Natasa Kukoc-Zivojnov; Uta Kessler; Stefan Rehart; Joachim Peter Kaltwasser; Dieter Hoelzer; Uwe Kalina; Oliver G Ottmann
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis.
Rheumatology (Oxford, England) 2001;40(3):302-9.
2001: Florian Fauth; Eckhart Weidmann; Hans Martin; Bernd Schneider; S Sonnhoff; Dieter Hoelzer
AC133 expression on acute myeloid leukemia blasts: correlation to FAB and to CD34 expression and possible implications for peripheral blood progenitor cell purging in AML.
Leukemia research 2001;25(3):191-6.
2001: Elena Puccetti; B Sennewald; F Fosca-Ferrara; Simone Boehrer; Andrea Bianchini; Dieter Hoelzer; Oliver G Ottmann; Clara Nervi; Martin Ruthardt
Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(6):385-92.
2001: Tanja Rossmanith; B Schröder; Gesine Bug; P Müller; T Klenner; R Knaus; Dieter Hoelzer; Oliver G Ottmann
Interleukin 3 improves the ex vivo expansion of primitive human cord blood progenitor cells and maintains the engraftment potential of scid repopulating cells.
Stem cells (Dayton, Ohio) 2001;19(4):313-20.
2001: Simone Boehrer; Kai Uwe Chow; Elena Puccetti; Martin Ruthardt; S Godzisard; A Krapohl; B Schneider; Dieter Hoelzer; Paris S Mitrou; Vivek M Rangnekar; Eckhart Weidmann
Deregulated expression of prostate apoptosis response gene-4 in less differentiated lymphocytes and inverse expressional patterns of par-4 and bcl-2 in acute lymphocytic leukemia.
The hematology journal : the official journal of the European Haematology Association / EHA 2001;2(2):103-7.
2001: Steffen Koschmieder; Gesine Bug; B Schröder; Tanja Rossmanith; Wolf-Karsten Hofmann; Uwe Kalina; Dieter Hoelzer; Oliver G Ottmann
Murine M2-10B4 and SL/SL cell lines differentially affect the balance between CD34+ cell expansion and maturation.
International journal of hematology 2001;73(1):71-7.
2001: Simone Boehrer; Thomas Hinz; Daniela K Schui; S Harder; Kai Uwe Chow; Bernd Schneider; Dieter Hoelzer; Paris S Mitrou; Eckhart Weidmann
T-large granular lymphocyte leukaemia with natural killer cell-like cytotoxicity and expression of two different alpha- and beta-T-cell receptor chains.
British journal of haematology 2001;112(1):201-3.
2000: Nicola Gökbuget; Dieter Hoelzer; Renate Arnold; Angelika Böhme; Claus R Bartram; M Freund; Arnold Ganser; Michael Kneba; W Langer; Thomas Lipp; Wolf-Dieter Ludwig; Georg Maschmeyer; Harald Rieder; Eckhard Thiel; A Weiss; D Messerer
Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL).
Hematology/oncology clinics of North America 2000;14(6):1307-25, ix.
2000: Uwe Kalina; K Ballas; Noriko Koyama; D Kauschat; C Miething; Joachim Arnemann; H Martin; Dieter Hoelzer; Oliver G Ottmann
Genomic organization and regulation of the human interleukin-18 gene.
Scandinavian journal of immunology 2000;52(6):525-30.
2000: Ulrich Mahlknecht; S Schnittger; Oliver G Ottmann; Claudia Schoch; M Mosebach; Wolfgang Hiddemann; Dieter Hoelzer
Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5).
Biochimica et biophysica acta 2000;1493(3):342-8.
2000: Dieter Hoelzer; Nicola Gökbuget
New approaches to acute lymphoblastic leukemia in adults: where do we go?
Seminars in oncology 2000;27(5):540-59.
2000: Uwe Kalina; Wolf-Karsten Hofmann; Steffen Koschmieder; Sandra Wagner; D Kauschat; Dieter Hoelzer; Oliver G Ottmann
Alteration of c-mpl-mediated signal transduction in CD34(+) cells from patients with myelodysplastic syndromes.
Experimental hematology 2000;28(10):1158-63.
2000: Eckhart Weidmann; Thomas Hinz; S Klein; Daniela K Schui; S Harder; Susanne Kriener; Dieter Kabelitz; Dieter Hoelzer; Paris S Mitrou
Cytotoxic hepatosplenic gammadelta T-cell lymphoma following acute myeloid leukemia bearing two distinct gamma chains of the T-cell receptor. Biologic and clinical features.
Haematologica 2000;85(10):1024-31.
2000: Kai Uwe Chow; J Ries; Eckhart Weidmann; F Pourebrahim; Simone Napieralski; M Stieler; Simone Boehrer; Mathias J Rummel; Jürgen Stein; Dieter Hoelzer; Paris S Mitrou
Induction of apoptosis using 2',2' difluorodeoxycytidine (gemcitabine) in combination with antimetabolites or anthracyclines on malignant lymphatic and myeloid cells. Antagonism or synergism depends on incubation schedule and origin of neoplastic cells.
Annals of hematology 2000;79(9):485-92.
2000: Wolf-Karsten Hofmann; W Jonathan Kell; Pierre Fenaux; Sylvie Castaigne; Arnold Ganser; Christine Chomienne; R Burnett; C Kowal; Dieter Hoelzer; Alan K Burnett
Oral 9-cis retinoic acid (Alitretinoin) in the treatment of myelodysplastic syndromes: results from a pilot study.
Leukemia 2000;14(9):1583-8.
2000: Uwe Kalina; D Kauschat; Noriko Koyama; H Nuernberger; K Ballas; Steffen Koschmieder; Gesine Bug; Wolf-Karsten Hofmann; Dieter Hoelzer; Oliver G Ottmann
IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(3):1307-13.
2000: Thomas J Vogl; Timo Hinrichs; Volkmar Jacobi; Angelika Böhme; Dieter Hoelzer
[Computed tomographic appearance of pulmonary mucormycosis].
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 2000;172(7):604-8.
2000: Elena Puccetti; Saskia Güller; Annette Orleth; Nicole Brüggenolte; Dieter Hoelzer; Oliver G Ottmann; Martin Ruthardt
BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity.
Cancer research 2000;60(13):3409-13.
2000: R Gottschalk; Christian Seidl; S Schilling; A Braner; Erhard Seifried; Dieter Hoelzer; Joachim Peter Kaltwasser
Iron-overload and genotypic expression of HFE mutations H63D/C282Y and transferrin receptor Hin6I and BanI polymorphism in german patients with hereditary haemochromatosis.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 2000;27(3):129-34.
2000: Wolf-Karsten Hofmann; Uwe Kalina; Steffen Koschmieder; Gernot Seipelt; Dieter Hoelzer; Oliver G Ottmann
Defective megakaryocytic development in myelodysplastic syndromes.
Leukemia & lymphoma 2000;38(1-2):13-9.
2000: Manuel Grez; S Becker; So Saulnier; H Knöss; Marion G Ott; Alexander B Maurer; Mary C Dinauer; Dieter Hoelzer; Reinhard Seger; Johann Peter Hossle
Gene therapy of chronic granulomatous disease.
Bone marrow transplantation 2000;25 Suppl 2():S99-104.
2000: Wolf-Karsten Hofmann; Gernot Seipelt; Oliver G Ottmann; Uwe Kalina; Steffen Koschmieder; J Brücher; N Frickhofen; M Klausmann; Paris S Mitrou; Dieter Hoelzer
Effect of treatment with amifostine used as a single agent in patients with refractory anemia on clinical outcome and serum tumor necrosis factor alpha levels.
Annals of hematology 2000;79(5):255-8.
2000: D Xie; Wolf-Karsten Hofmann; N Mori; Carl W Miller; Dieter Hoelzer; H Phillip Koeffler
Allelotype analysis of the myelodysplastic syndrome.
Leukemia 2000;14(5):805-10.
2000: Gernot Seipelt; Oliver G Ottmann; Dieter Hoelzer
Cytokine therapy for myelodysplastic syndrome.
Current opinion in hematology 2000;7(3):156-60.
2000: Florian Fauth; Hans Martin; S Sonnhoff; Heike Bialleck; M Wiesneth; B Mihanovic; Dieter Hoelzer
Purging of G-CSF-mobilized peripheral autografts in acute leukemia with mafosfamide and amifostine to protect normal progenitor cells.
Bone marrow transplantation 2000;25(8):831-6.
2000: Barbara Wassmann; Gernot Seipelt; F Länger; Mathias J Rummel; Angelika Böhme; Martin-Leo Hansmann; Dieter Hoelzer
[Pancytopenia, hepatosplenomegaly and fever in a 49-year old patient].
Der Internist 2000;41(3):304-8.
2000: Stefan A Klein; Christian Klebba; D Kauschat; Martine Pape; L Ozmen; Dieter Hoelzer; Oliver G Ottmann; Uwe Kalina
Interleukin-18 stimulates HIV-1 replication in a T-cell line.
European cytokine network 2000;11(1):47-52.
2000: R Gottschalk; R Wigand; C F Dietrich; Gerhard Oremek; F Liebisch; Dieter Hoelzer; Joachim Peter Kaltwasser
Total iron-binding capacity and serum transferrin determination under the influence of several clinical conditions.
Clinica chimica acta; international journal of clinical chemistry 2000;293(1-2):127-38.
2000: Christian Klebba; Oliver G Ottmann; Michaela Scherr; Martine Pape; Joachim W Engels; Manuel Grez; Dieter Hoelzer; Stefan A Klein
Retrovirally expressed anti-HIV ribozymes confer a selective survival advantage on CD4+ T cells in vitro.
Gene therapy 2000;7(5):408-16.
2000: Kai Uwe Chow; Mathias J Rummel; Eckhart Weidmann; J Ries; P Jantschke; Simone Boehrer; F Pourebrahim; Simone Napieralski; Jürgen Stein; Hans Martin; Dieter Hoelzer; Paris S Mitrou
Induction of apoptosis by 2-chloro-2'deoxyadenosine (2-CdA) alone and in combination with other cytotoxic drugs: synergistic effects on normal and neoplastic lymphocytes by addition of doxorubicin and mitoxantrone.
Leukemia & lymphoma 2000;36(5-6):559-67.
2000: Arnold Ganser; G Heil; Gernot Seipelt; W Hofmann; JT Fischer; W Langer; W Brockhaus; K Kolbe; Thomas Ittel; N Brack; H G Fuhr; P Knuth; K Höffken; Lothar Bergmann; Dieter Hoelzer
Intensive chemotherapy with idarubicin, ara-C, etoposide, and m-AMSA followed by immunotherapy with interleukin-2 for myelodysplastic syndromes and high-risk Acute Myeloid Leukemia (AML).
Annals of hematology 2000;79(1):30-5.
2000: Johannes Atta; Florian Fauth; M Keyser; Eduard K Petershofen; C Weber; G Lippok; Dieter Hoelzer; Hans Martin
Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction.
Bone marrow transplantation 2000;25(1):97-104.
1999: Eric Archimbaud; O G Ottmann; J A Yin; Klaus Lechner; Hervé Dombret; MA Sanz; Gerhard Heil; Pierre Fenaux; W Brugger; A Barge; C O'Brien-Ewen; James Matcham; Dieter Hoelzer
A randomized, double-blind, placebo-controlled study with pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) as an adjunct to chemotherapy for adults with de novo acute myeloid leukemia.
Blood 1999;94(11):3694-701.
1999: Mathias J Rummel; Kai Uwe Chow; E Jäger; Lothar Leimer; D K Hossfeld; Lothar Bergmann; H D Peters; Martin-Leo Hansmann; A Meyer; Dieter Hoelzer; Paris S Mitrou
Intermittent 2-hour-infusion of cladribine as first-line therapy or in first relapse of progressive advanced low-grade and mantle cell lymphomas.
Leukemia & lymphoma 1999;35(1-2):129-38.
1999: E Wiedmann; B Baican; Andreas Hertel; Richard P Baum; Kai Uwe Chow; B Knupp; Stefan Adams; Gustav Hör; Dieter Hoelzer; Paris S Mitrou
Positron emission tomography (PET) for staging and evaluation of response to treatment in patients with Hodgkin's disease.
Leukemia & lymphoma 1999;34(5-6):545-51.
1999: Thomas Sternsdorf; Elena Puccetti; Kirsten Jensen; Dieter Hoelzer; Hans Will; Oliver G Ottmann; Martin Ruthardt
PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
Molecular and cellular biology 1999;19(7):5170-8.
1999: Jürgen Krauter; Arnold Ganser; Lothar Bergmann; A Raghavachar; Dieter Hoelzer; M Lübbert; G Schlimok; Renate Arnold; Holger Kirchner; M Port; Gerhard Heil
Association between structural and numerical chromosomal aberrations in acute myeloblastic leukemia: a study by RT-PCR and FISH in 447 patients with de-novo AML.
Annals of hematology 1999;78(6):265-9.
1999: Stefan A Klein; Oliver G Ottmann; K Ballas; Thomas S Dobmeyer; Martine Pape; E Weidmann; Dieter Hoelzer; Uwe Kalina
Quantification of human interleukin 18 mRNA expression by competitive reverse transcriptase polymerase chain reaction.
Cytokine 1999;11(6):451-8.
1999: Wolf-Karsten Hofmann; Uwe Kalina; Gernot Seipelt; K Hoffmann; Sandra Wagner; Dieter Hoelzer; Oliver G Ottmann
Megakaryocytic growth in patients with refractory anemia is suppressed by treatment with interferon alpha.
European journal of haematology 1999;62(5):336-40.
1999: Wolf-Karsten Hofmann; Oliver G Ottmann; Dieter Hoelzer
Memorial lecture. Megakaryocytic growth factors: is there a new approach for management of thrombocytopenia in patients with malignancies?
Leukemia 1999;13 Suppl 1():S14-8.
1999: Nicola Gökbuget; Renate Arnold; Thomas Büchner; M Freund; Winfried Gassmann; Gerhard Heil; Wolfgang Hiddemann; Helmut Löffler; Thomas Lipp; Wolf-Dieter Ludwig; Georg Maschmeyer; Eckhard Thiel; D Messerer; Dieter Hoelzer
[Treatment of adult acute lymphoblastic leukemia].
Praxis 1999;88(10):407-20.
1999: Wolf-Karsten Hofmann; Arnold Ganser; Gernot Seipelt; Oliver G Ottmann; C Zander; G Geissler; K Hoffmann; K Höffken; JT Fischer; G Isele; Dieter Hoelzer
Treatment of patients with low-risk myelodysplastic syndromes using a combination of all-trans retinoic acid, interferon alpha, and granulocyte colony-stimulating factor.
Annals of hematology 1999;78(3):125-30.
1999: Wolf-Karsten Hofmann; Uwe Kalina; Sandra Wagner; Gernot Seipelt; C Ries; Dieter Hoelzer; Oliver G Ottmann
Characterization of defective megakaryocytic development in patients with myelodysplastic syndromes.
Experimental hematology 1999;27(3):395-400.
1999: Mathias J Rummel; G Käfer; M Pfreundschuh; E Jäger; U Reinhardt; Paris S Mitrou; Dieter Hoelzer; Lothar Bergmann
Fludarabine and epirubicin in the treatment of chronic lymphocytic leukaemia: a German multicenter phase II study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(2):183-8.
1999: Mathias J Rummel; Kai Uwe Chow; E Jäger; D K Hossfeld; Lothar Bergmann; H D Peters; Martin-Leo Hansmann; A Meyer; Dieter Hoelzer; Paris S Mitrou
Treatment of mantle-cell lymphomas with intermittent two-hour infusion of cladribine as first-line therapy or in first relapse.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1999;10(1):115-7.
1999: Wolf-Karsten Hofmann; Oliver G Ottmann; Dieter Hoelzer
Megakaryocytic growth factors: is there a new approach for management of thrombocytopenia in patients with malignancies?
Leukemia 1999;13(1):14-8.
1998: Oliver G Ottmann; Dieter Hoelzer
Growth factors in the treatment of acute lymphoblastic leukemia.
Leukemia research 1998;22(12):1171-8.
1998: Angelika Böhme; M Wolter; Dieter Hoelzer
L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia.
Annals of hematology 1998;77(5):235-8.
1998: Andrea Schilz; Gaby Brouns; H Knöss; Oliver G Ottmann; Dieter Hoelzer; Axel A Fauser; Adrian J Thrasher; Manuel Grez
High efficiency gene transfer to human hematopoietic SCID-repopulating cells under serum-free conditions.
Blood 1998;92(9):3163-71.
1998: Jürgen Krauter; W Peter; U Pascheberg; Barbara Heinze; Lothar Bergmann; Dieter Hoelzer; M Lübbert; G Schlimok; Renate Arnold; Holger Kirchner; M Port; Arnold Ganser; Gerhard Heil
Detection of karyotypic aberrations in acute myeloblastic leukaemia: a prospective comparison between PCR/FISH and standard cytogenetics in 140 patients with de novo AML.
British journal of haematology 1998;103(1):72-8.
1998: Wolf-Dieter Ludwig; Harald Rieder; Claus R Bartram; Barbara Heinze; Stefan Schwartz; Winfried Gassmann; Helmut Löffler; Dieter K Hossfeld; Gerhard Heil; S Handt; Axel Heyll; Helmut Diedrich; K Fischer; A Weiss; B Völkers; U Aydemir; Christa Fonatsch; Nicola Gökbuget; Eckhard Thiel; Dieter Hoelzer
Immunophenotypic and genotypic features, clinical characteristics, and treatment outcome of adult pro-B acute lymphoblastic leukemia: results of the German multicenter trials GMALL 03/87 and 04/89.
Blood 1998;92(6):1898-909.
1998: Angelika Böhme; PM Shah; W Stille; Dieter Hoelzer
[Antibiotic therapy in leukopenia].
Praxis 1998;87(36):1120-5.
1998: Harald Rieder; C Bonwetsch; L A Janssen; Jürgen Maurer; Johannes W G Janssen; Stefan Schwartz; Wolf-Dieter Ludwig; Winfried Gassmann; Claus R Bartram; Eckhard Thiel; Helmut Löffler; Nicola Gökbuget; Dieter Hoelzer; Christa Fonatsch
High rate of chromosome abnormalities detected by fluorescence in situ hybridization using BCR and ABL probes in adult acute lymphoblastic leukemia.
Leukemia 1998;12(9):1473-81.
1998: S Becker; S Wasser; M Hauses; Johann Peter Hossle; Marion G Ott; Mary C Dinauer; Arnold Ganser; Dieter Hoelzer; Reinhard Seger; Manuel Grez
Correction of respiratory burst activity in X-linked chronic granulomatous cells to therapeutically relevant levels after gene transfer into bone marrow CD34+ cells.
Human gene therapy 1998;9(11):1561-70.
1998: Angelika Böhme; PM Shah; W Stille; Dieter Hoelzer
Piperacillin/tazobactam versus cefepime as initial empirical antimicrobial therapy in febrile neutropenic patients: a prospective randomized pilot study.
European journal of medical research 1998;3(7):324-30.
1998: Thomas S Dobmeyer; Stefan A Klein; JM Dobmeyer; B Raffel; S Findhammer; Dieter Hoelzer; Eilke B Helm; R Rossol; Dieter Kabelitz
Differential expression of bcl-2 and susceptibility to programmed cell death in lymphocytes of HIV-1-infected individuals.
Clinical immunology and immunopathology 1998;87(3):230-9.
1998: Gernot Seipelt; Wolf-Karsten Hofmann; H Martin; Barbara Wassmann; A Boehme; Oliver G Ottmann; Dieter Hoelzer
Comparison of toxicity and outcome in patients with acute myeloid leukemia treated with high-dose cytosine arabinoside consolidation after induction with a regimen containing idarubicin or daunorubicin.
Annals of hematology 1998;76(3-4):145-51.
1998: R Gottschalk; Christian Seidl; Torsten Löffler; Erhard Seifried; Dieter Hoelzer; Joachim Peter Kaltwasser
HFE codon 63/282 (H63D/C282Y) dimorphism in German patients with genetic hemochromatosis.
Tissue antigens 1998;51(3):270-5.
1998: R Rossol; JM Dobmeyer; Thomas S Dobmeyer; Stefan A Klein; S Rossol; Daniela Wesch; Dieter Hoelzer; Dieter Kabelitz; Eilke B Helm
Increase in Vdelta1+ gammadelta T cells in the peripheral blood and bone marrow as a selective feature of HIV-1 but not other virus infections.
British journal of haematology 1998;100(4):728-34.
1998: Thomas S Dobmeyer; JM Dobmeyer; S A Klein; Daniela Wesch; S Wagner; Eilke B Helm; Dieter Hoelzer; R Rossol; Dieter Kabelitz
Mechanism of gamma sigma T-cell-mediated inhibition of stem cell differentiation in vitro: possible relevance for myelosuppression in HIV-infected individuals.
Cellular immunology 1998;184(1):26-36.
1998: T Karakas; U Maurer; Eckhart Weidmann; CC Miething; Dieter Hoelzer; Lothar Bergmann
High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1998;9(2):159-65.
1998: Dieter Hoelzer; T M Fliedner
A tribute to Theodor M. Fliedner.
Stem cells (Dayton, Ohio) 1998;16 Suppl 1():ix-xvii.
1998: Angelika Böhme; PM Shah; W Stille; Dieter Hoelzer
Prospective randomized study to compare imipenem 1.5 grams per day vs. 3.0 grams per day in infections of granulocytopenic patients.
The Journal of infection 1998;36(1):35-42.
1997: Gerhard Heil; Dieter Hoelzer; MA Sanz; Klaus Lechner; J A Liu Yin; G Papa; L Noens; Jeff Szer; Arnold Ganser; C O'Brien; James Matcham; A Barge
A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia. The International Acute Myeloid Leukemia Study Group.
Blood 1997;90(12):4710-8.
1997: Oliver G Ottmann; Gernot Seipelt; Dieter Hoelzer
[Clinical administration of hematopoietic growth factors. When and where?].
Der Internist 1997;38(12):1160-7.
1997: U Maurer; Eckhart Weidmann; T Karakas; Dieter Hoelzer; Lothar Bergmann
Wilms tumor gene (wt1) mRNA is equally expressed in blast cells from acute myeloid leukemia and normal CD34+ progenitors.
Blood 1997;90(10):4230-2.
1997: Nicola Gökbuget; Dieter Hoelzer
Vindesine in the treatment of leukaemia.
Leukemia & lymphoma 1997;26(5-6):497-506.
1997: U Maurer; J Brieger; Eckhart Weidmann; Paris S Mitrou; Dieter Hoelzer; Lothar Bergmann
The Wilms' tumor gene is expressed in a subset of CD34+ progenitors and downregulated early in the course of differentiation in vitro.
Experimental hematology 1997;25(9):945-50.
1997: Lothar Bergmann; CC Miething; U Maurer; J Brieger; T Karakas; Eckhart Weidmann; Dieter Hoelzer
High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome.
Blood 1997;90(3):1217-25.
1997: Stefan A Klein; JM Dobmeyer; Thomas S Dobmeyer; Martine Pape; Oliver G Ottmann; Eilke B Helm; Dieter Hoelzer; R Rossol
Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry.
AIDS (London, England) 1997;11(9):1111-8.
1997: Eckhart Weidmann; J Brieger; T Karakas; U Maurer; U Pascheberg; Dieter Hoelzer; Paris S Mitrou; Lothar Bergmann
Establishment and characterization of a new, factor-independent acute myeloid leukemia line designated Ei501.
Leukemia 1997;11(5):709-13.
1997: Winfried Gassmann; Helmut Löffler; Eckhard Thiel; Wolf-Dieter Ludwig; Stefan Schwartz; Torsten Haferlach; J Maurer; Harald Rieder; Christa Fonatsch; Nicola Gökbuget; Dieter Hoelzer
Morphological and cytochemical findings in 150 cases of T-lineage acute lymphoblastic leukaemia in adults. German Multicentre ALL Study Group (GMALL).
British journal of haematology 1997;97(2):372-82.
1997: R Wigand; R Gottschalk; Albrecht Falkenbach; Torsten Matthias; Joachim Peter Kaltwasser; Dieter Hoelzer
[Detection of dsDNA antibodies in diagnosis of systemic lupus erythematosus--comparative studies of diagnostic effectiveness of 3 ELISA methods with different antigens and a Crithidia luciliae immunofluorescence test].
Zeitschrift für Rheumatologie 1997;56(2):53-62.
1997: Dieter Kabelitz; Thomas Hinz; Thomas S Dobmeyer; U Mentzel; S Marx; A Böhme; B Arden; R Rossol; Dieter Hoelzer
Clonal expansion of Vgamma3/Vdelta3-expressing gammadelta T cells in an HIV-1/2-negative patient with CD4 T-cell deficiency.
British journal of haematology 1997;96(2):266-71.
1997: Thomas S Dobmeyer; S Findhammer; JM Dobmeyer; S A Klein; B Raffel; Dieter Hoelzer; Eilke B Helm; Dieter Kabelitz; R Rossol
Ex vivo induction of apoptosis in lymphocytes is mediated by oxidative stress: role for lymphocyte loss in HIV infection.
Free radical biology & medicine 1997;22(5):775-85.
1996: T Karakas; Lothar Bergmann; HJ Stutte; E Jäger; A Knuth; Eckhart Weidmann; Paris S Mitrou; Dieter Hoelzer
Peripheral T-cell lymphomas respond well to vincristine, adriamycin, cyclophosphamide, prednisone and etoposide (VACPE) and have a similar outcome as high-grade B-cell lymphomas.
Leukemia & lymphoma 1996;24(1-2):121-9.
1996: Angelika Böhme; Gudrun Just-Nübling; L Bergmann; P M Shah; W Stille; Dieter Hoelzer
Itraconazole for prophylaxis of systemic mycoses in neutropenic patients with haematological malignancies.
The Journal of antimicrobial chemotherapy 1996;38(6):953-61.
1996: Harald Rieder; Wolf-Dieter Ludwig; Winfried Gassmann; J Maurer; J W Janssen; Nicola Gökbuget; Stefan Schwartz; Eckhard Thiel; Helmut Löffler; Claus R Bartram; Dieter Hoelzer; Christa Fonatsch
Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia.
British journal of haematology 1996;95(4):678-91.
1996: Angelika Böhme; Dieter Hoelzer
Liposomal amphotericin B as early empiric antimycotic therapy of pneumonia in granulocytopenic patients.
Mycoses 1996;39(11-12):419-26.
1996: Dieter Hoelzer; Nicola Gökbuget; R Arnold; Thomas Büchner; Mathias Freund; Winfried Gassmann; Gerhard Heil; Wolfgang Hiddemann; Helmut Löffler; T Lipp; Wolf-Dieter Ludwig; Georg Maschmeyer; Eckhard Thiel; D Messerer
[Acute lymphatic leukemia of the adult. Diagnosis, risk groups and therapy].
Der Internist 1996;37(10):994-1007.
1996: J Atta; H Martin; J Bruecher; S Elsner; B Wassmann; C Rode; A Russ; G Kvalheim; Dieter Hoelzer
Residual leukemia and immunomagnetic bead purging in patients with BCR-ABL-positive acute lymphoblastic leukemia.
Bone marrow transplantation 1996;18(3):541-8.
1996: Arnold Ganser; Dieter Hoelzer
Clinical use of hematopoietic growth factors in the myelodysplastic syndromes.
Seminars in hematology 1996;33(3):186-95.
1996: Wolf-Karsten Hofmann; Oliver G Ottmann; Arnold Ganser; Dieter Hoelzer
Myelodysplastic syndromes: clinical features.
Seminars in hematology 1996;33(3):177-85.
1996: RG Geissler; R Rossol; U Mentzel; Oliver G Ottmann; A S Klein; Peter Gute; E B Helm; Dieter Hoelzer; Arnold Ganser
Gamma delta-T cell-receptor-positive lymphocytes inhibit human hematopoietic progenitor cell growth in HIV type 1-infected patients.
AIDS research and human retroviruses 1996;12(7):577-84.
1996: Arnold Ganser; A Maurer; C Contzen; Gernot Seipelt; Oliver G Ottmann; C Schadeck-Gressel; K Kolbe; R Haas; C Zander; R Reutzel; Dieter Hoelzer
Improved multilineage response of hematopoiesis in patients with myelodysplastic syndromes to a combination therapy with all-trans-retinoic acid, granulocyte colony-stimulating factor, erythropoietin and alpha-tocopherol.
Annals of hematology 1996;72(4):237-44.
1996: Stefan A Klein; JM Dobmeyer; Thomas S Dobmeyer; D Falke; Dieter Kabelitz; K Friese; Eilke B Helm; Dieter Hoelzer; R Rossol-Voth
TNF-alpha mediated apoptosis of CD4 positive T-lymphocytes. A model of T-cell depletion in HIV infected individuals.
European journal of medical research 1996;1(5):249-58.
1996: Matthias Eder; P Hemmati; Uwe Kalina; O G Ottman; Dieter Hoelzer; S D Lyman; Arnold Ganser
Effects of Flt3 ligand and interleukin-7 on in vitro growth of acute lymphoblastic leukemia cells.
Experimental hematology 1996;24(2):371-7.
1996: Dieter Hoelzer; Wolf-Dieter Ludwig; Eckhard Thiel; Winfried Gassmann; Helmut Löffler; Christa Fonatsch; Harald Rieder; Gerhard Heil; Barbara Heinze; R Arnold; Dieter K Hossfeld; Thomas Büchner; P Koch; Mathias Freund; Wolfgang Hiddemann; Georg Maschmeyer; Axel Heyll; Carlo Aul; T Faak; R Kuse; T H Ittel; M Gramatzki; Helmut Diedrich; K Kolbe; H G Fuhr; K Fischer; C Schadeck-Gressel; A Weiss; I Strohscheer; Bernd Metzner; U Fabry; Nicola Gökbuget; B Völkers; D Messerer; K Uberla
Improved outcome in adult B-cell acute lymphoblastic leukemia.
Blood 1996;87(2):495-508.
1995: Lothar Bergmann; T Karakas; G Lautenschlager; E Jager; A Knuth; Paris S Mitrou; Dieter Hoelzer
Vincristine, doxorubicin, cyclophosphamide, prednisone and etoposide (VACPE) in high-grade non-Hodgkin's lymphoma--a multicenter phase II study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(10):1019-24.
1995: H Martin; J Atta; P Zumpe; Matthias Eder; S Elsner; C Rode; B Wassmann; J Bruecher; Dieter Hoelzer
Purging of peripheral blood stem cells yields BCR-ABL-negative autografts in patients with BCR-ABL-positive acute lymphoblastic leukemia.
Experimental hematology 1995;23(14):1612-8.
1995: Lothar Bergmann; D K Schui; J Brieger; Eckhart Weidmann; Paris S Mitrou; Dieter Hoelzer
The inhibition of lymphokine-activated killer cells in acute myeloblastic leukemia is mediated by transforming growth factor-beta 1.
Experimental hematology 1995;23(14):1574-80.
1995: Angelika Böhme; Arnold Ganser; Dieter Hoelzer
Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL.
Annals of hematology 1995;71(6):311-2.
1995: Angelika Böhme; Gudrun Just-Nübling; L Bergmann; P M Shah; W Stille; Dieter Hoelzer
A randomized study of imipenem compared to cefotaxime plus piperacillin as initial therapy of infections in granulocytopenic patients.
Infection 1995;23(6):349-55.
1995: Gerhard Heil; Paris S Mitrou; Dieter Hoelzer; Mathias Freund; H Link; Gerhard Ehninger; B Steinke; S Ohl; Hannes Wandt; E Fackler-Schwalbe
High-dose cytosine arabinoside and daunorubicin postremission therapy in adults with de novo acute myeloid leukemia. Long-term follow-up of a prospective multicenter trial.
Annals of hematology 1995;71(5):219-25.
1995: Thomas S Dobmeyer; B Raffel; JM Dobmeyer; S Findhammer; Stefan A Klein; Dieter Kabelitz; Dieter Hoelzer; Eilke B Helm; R Rossol
Decreased function of monocytes and granulocytes during HIV-1 infection correlates with CD4 cell counts.
European journal of medical research 1995;1(1):9-15.
1995: J Brieger; Eckhart Weidmann; U Maurer; Dieter Hoelzer; Paris S Mitrou; Lothar Bergmann
The Wilms' tumor gene is frequently expressed in acute myeloblastic leukemias and may provide a marker for residual blast cells detectable by PCR.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(8):811-6.
1995: Mei-Jie Zhang; Dieter Hoelzer; Mary M Horowitz; Robert Peter Gale; D Messerer; John P Klein; H Löffler; Kathleen A Sobocinski; E Thiel; D J Weisdorf
Long-term follow-up of adults with acute lymphoblastic leukemia in first remission treated with chemotherapy or bone marrow transplantation. The Acute Lymphoblastic Leukemia Working Committee.
Annals of internal medicine 1995;123(6):428-31.
1995: K Fenchel; Lothar Bergmann; P Wijermans; A Engert; H Pralle; Paris S Mitrou; V Diehl; Dieter Hoelzer
Clinical experience with fludarabine and its immunosuppressive effects in pretreated chronic lymphocytic leukemias and low-grade lymphomas.
Leukemia & lymphoma 1995;18(5-6):485-92.
1995: RG Geissler; J Muth; A Maurer; U Mentzel; M Mag; Joachim W Engels; Dieter Hoelzer; Arnold Ganser
Modified antisense oligodeoxynucleotides against the splice acceptor site of tat do not inhibit in vitro hematopoietic colony growth in HIV-positive patients.
Annals of hematology 1995;71(2):89-95.
1995: Oliver G Ottmann; Dieter Hoelzer; E Gracien; Arnold Ganser; K Kelly; R Reutzel; T Lipp; F W Busch; M Schwonzen; Gerhard Heil
Concomitant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult acute lymphoblastic leukemia: a randomized phase III trial.
Blood 1995;86(2):444-50.
1995: Gernot Seipelt; Dieter Hoelzer
[Current aspects of therapy in chronic and acute leukemias].
Schweizerische medizinische Wochenschrift 1995;125(27-28):1354-63.
1995: Eckhart Weidmann; J Brieger; Lothar Bergmann; Dieter Hoelzer; Paris S Mitrou
AML blasts variably express interleukin 2 receptor alpha, beta or gamma chains without measurable effects on proliferation, cytokine message expression or surface expression of adhesion molecules upon stimulation with interleukin 2.
Leukemia research 1995;19(7):469-76.
1995: Dieter Hoelzer; Gernot Seipelt
Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the treatment of myeloid leukemia.
Current opinion in hematology 1995;2(3):196-203.
1995: RG Geissler; Arnold Ganser; K Hübner; Gustav Hör; Dieter Hoelzer
[47-year-old patient with pulmonary hypertension, anemia and thrombocytopenia].
Der Internist 1995;36(4):385-8.
1995: Harald von Melchner; Arnold Ganser; H Martin; Manuel Grez; Dieter Hoelzer
[Molecular mechanisms of hematopoietic stem cell differentiation].
Der Internist 1995;36(4):372-7.
1995: Eckhart Weidmann; J Brieger; B Jahn; Dieter Hoelzer; Lothar Bergmann; Paris S Mitrou
Lactate dehydrogenase-release assay: a reliable, nonradioactive technique for analysis of cytotoxic lymphocyte-mediated lytic activity against blasts from acute myelocytic leukemia.
Annals of hematology 1995;70(3):153-8.
1995: A B Maurer; Arnold Ganser; Gernot Seipelt; Oliver G Ottmann; U Mentzel; G R Geissler; Dieter Hoelzer
Changes in erythroid progenitor cell and accessory cell compartments in patients with myelodysplastic syndromes during treatment with all-trans retinoic acid and haemopoietic growth factors.
British journal of haematology 1995;89(3):449-56.
1995: B Jahn; Lothar Bergmann; Eckhart Weidmann; J Brieger; K Fenchel; U Schwulera; Dieter Hoelzer; Paris S Mitrou
Bone marrow-derived T-cell clones obtained from untreated acute myelocytic leukemia exhibit blast directed autologous cytotoxicity.
Leukemia research 1995;19(2):73-82.
1995: Gerhard Heil; L Chadid; Dieter Hoelzer; Gernot Seipelt; Paris S Mitrou; C Huber; K Kolbe; Roland Mertelsmann; A Lindemann; J Frisch
GM-CSF in a double-blind randomized, placebo controlled trial in therapy of adult patients with de novo acute myeloid leukemia (AML).
Leukemia 1995;9(1):3-9.
1995: Lothar Bergmann; Gerhard Heil; K Kolbe; E Lengfelder; E Puzicha; H Martin; Jürgen Lohmeyer; Paris S Mitrou; Dieter Hoelzer
Interleukin-2 bolus infusion as late consolidation therapy in 2nd remission of acute myeloblastic leukemia.
Leukemia & lymphoma 1995;16(3-4):271-9.
1994: J Brieger; Eckhart Weidmann; K Fenchel; Paris S Mitrou; Dieter Hoelzer; Lothar Bergmann
The expression of the Wilms' tumor gene in acute myelocytic leukemias as a possible marker for leukemic blast cells.
Leukemia 1994;8(12):2138-43.
1994: B Wassmann; H Martin; S Elsner; J Bruecher; F Thaiss; R A Stahl; Dieter Hoelzer
Microangiopathic hemolytic anemia and renal impairment following autologous bone marrow transplantation: a case of hemolytic uremic syndrome?
Bone marrow transplantation 1994;14(5):849-51.
1994: Gerhard Ehninger; C M Rutt; A Ebert; P Harf; Dieter Hoelzer; Dietrich Niethammer; J von Keller; A Rodert; Ulrich Schuler
[Accumulation of German bone marrow donor data].
Deutsche medizinische Wochenschrift (1946) 1994;119(40):1359-64.
1994: RG Geissler; Arnold Ganser; Oliver G Ottmann; Peter Gute; A Morawetz; P Guba; Eilke B Helm; Dieter Hoelzer
In vitro improvement of bone marrow-derived hematopoietic colony formation in HIV-positive patients by alpha-D-tocopherol and erythropoietin.
European journal of haematology 1994;53(4):201-6.
1994: D Messerer; A Neiss; Mary M Horowitz; Dieter Hoelzer; Robert Peter Gale
Comparison of chemotherapy and bone marrow transplants using two independent clinical databases.
Journal of clinical epidemiology 1994;47(10):1119-26.
1994: Arnold Ganser; Dieter Hoelzer
Acute leukemia.
Current opinion in hematology 1994;1(4):248-55.
1994: Gerhard Heil; E Gunsilius; Dieter Hoelzer; Eckhard Thiel; Hermann Heimpel
Peroxidase expression in acute unclassified leukemias: ultrastructural studies in combination with immunophenotyping.
Leukemia & lymphoma 1994;14(1-2):103-9.
1994: Dieter Hoelzer
Therapy and prognostic factors in adult acute lymphoblastic leukaemia.
Baillière's clinical haematology 1994;7(2):299-320.
1994: Jörg Schubert; H G Vogt; M Zielinska-Skowronek; Mathias Freund; Joachim Peter Kaltwasser; Dieter Hoelzer; Reinhold E Schmidt
Development of the glycosylphosphatitylinositol-anchoring defect characteristic for paroxysmal nocturnal hemoglobinuria in patients with aplastic anemia.
Blood 1994;83(8):2323-8.
1994: Gernot Seipelt; Arnold Ganser; H Duranceyk; A Maurer; Oliver G Ottmann; Dieter Hoelzer
Induction of soluble IL-2 receptor in patients with myelodysplastic syndromes undergoing high-dose interleukin-3 treatment.
Annals of hematology 1994;68(4):167-70.
1994: Frank Griesinger; H Elfers; Wolf-Dieter Ludwig; M Falk; Harald Rieder; Jochen Harbott; Fritz H Lampert; Barbara Heinze; Dieter Hoelzer; Eckhard Thiel
Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11).
Leukemia 1994;8(4):542-8.
1994: Angelika Böhme; Dieter Hoelzer
[Pneumonia after cytostatic drug therapy].
Pneumologie (Stuttgart, Germany) 1994;48(2):121-5.
1994: H Martin; J Atta; J Bruecher; S Elsner; C Schardt; M Stadler; Harald von Melchner; Dieter Hoelzer
In patients with BCR-ABL-positive ALL in CR peripheral blood contains less residual disease than bone marrow: implications for autologous BMT.
Annals of hematology 1994;68(2):85-7.
1994: Dieter Hoelzer
Treatment of acute lymphoblastic leukemia.
Seminars in hematology 1994;31(1):1-15.
1994: Dieter Hoelzer
Application of hemopoietic growth factors in MDS.
Acta haematologica Polonica 1994;25(2 Suppl 1):104-11.
1993: H Martin; J Bruecher; R Claudé; Dieter Hoelzer
Cumulative chemotherapy increases mafosfamide toxicity for normal progenitor cells in AML patients: rationale for cryopreserving adapted-dose purged marrow early in first complete remission.
Bone marrow transplantation 1993;12(5):495-9.
1993: A B Maurer; Arnold Ganser; R Buhl; Gernot Seipelt; Oliver G Ottmann; U Mentzel; RG Geissler; Dieter Hoelzer
Restoration of impaired cytokine secretion from monocytes of patients with myelodysplastic syndromes after in vivo treatment with GM-CSF or IL-3.
Leukemia 1993;7(11):1728-33.
1993: Arnold Ganser; Oliver G Ottmann; Dieter Hoelzer
Interleukin 3 and interleukin 3/GM-CSF combination therapy--clinical implications.
Stem cells (Dayton, Ohio) 1993;11(6):465-73.
1993: Oliver G Ottmann; Arnold Ganser; M Freund; Gerhard Heil; W Hiddemann; W Heit; E Gracien; Dieter Hoelzer
Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia. A pilot study.
Annals of hematology 1993;67(4):161-7.
1993: Dieter Hoelzer; Eckhard Thiel; Wolf-Dieter Ludwig; Helmut Löffler; Thomas Büchner; Mathias Freund; Gerhard Heil; Wolfgang Hiddemann; Georg Maschmeyer; B Völkers
Follow-up of the first two successive German multicentre trials for adult ALL (01/81 and 02/84). German Adult ALL Study Group.
Leukemia 1993;7 Suppl 2():S130-4.
1993: Gernot Seipelt; Arnold Ganser; H Duranceyk; A Maurer; Oliver G Ottmann; Dieter Hoelzer
Induction of TNF-alpha in patients with myelodysplastic syndromes undergoing treatment with interleukin-3.
British journal of haematology 1993;84(4):749-51.
1993: Arnold Ganser; Dieter Hoelzer
Therapeutic value of interleukin-3 given alone or in combination with other cytokines.
Nouvelle revue française d'hématologie 1993;35(3):245-6.
1993: Dieter Hoelzer
[Acute lymphatic leukemia. Risk factors, chemotherapy/radiotherapy].
Der Internist 1993;34(6):526-33.
1993: S Lob; Lothar Bergmann; H Müller; Volkmar Jacobi; Dieter Hoelzer
[Pleomorphic T-cell lymphoma. The diagnostic problems, therapeutic possibilities and infection-induced complications].
Deutsche medizinische Wochenschrift (1946) 1993;118(21):780-4.
1993: Lothar Bergmann; K Fenchel; B Jahn; Paris S Mitrou; Dieter Hoelzer
Immunosuppressive effects and clinical response of fludarabine in refractory chronic lymphocytic leukemia.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(5):371-5.
1993: U Mentzel; H Vogt; R Rossol; RG Geissler; A Maurer; Arnold Ganser; W E Trommer; Dieter Hoelzer
Analysis of lymphocyte subsets in patients with aplastic anemia before and during immunosuppressive therapy.
Annals of hematology 1993;66(3):127-9.
1993: Dieter Hoelzer
Therapy of the newly diagnosed adult with acute lymphoblastic leukemia.
Hematology/oncology clinics of North America 1993;7(1):139-60.
1993: RG Geissler; Oliver G Ottmann; K Kleiner; U Mentzel; A Bickelhaupt; Dieter Hoelzer; Arnold Ganser
Decreased haematopoietic colony growth in long-term bone marrow cultures of HIV-positive patients.
Research in virology 1993;144(1):69-73.
1992: C Schardt; M Stadler; Dieter Hoelzer; Arnold Ganser
Lack of c-kit proto-oncogene rearrangement in patients with acute lymphoblastic leukemia (ALL) and the t(4;11)(q21;q23) translocation.
Leukemia 1992;6(10):1079-80.
1992: Matthias Eder; Oliver G Ottmann; T E Hansen-Hagge; C R Bartram; S Falk; S Gillis; Dieter Hoelzer; Arnold Ganser
In vitro culture of common acute lymphoblastic leukemia blasts: effects of interleukin-3, interleukin-7, and accessory cells.
Blood 1992;79(12):3274-84.
1992: Arnold Ganser; Dieter Hoelzer
Clinical course of myelodysplastic syndromes.
Hematology/oncology clinics of North America 1992;6(3):607-18.
1992: Arnold Ganser; Dieter Hoelzer
Treatment of myelodysplastic syndromes with hematopoietic growth factors.
Hematology/oncology clinics of North America 1992;6(3):633-53.
1992: C Schardt; Oliver G Ottmann; Dieter Hoelzer; Arnold Ganser
Acute lymphoblastic leukemia with the (4;11) translocation: combined cytogenetic, immunological and molecular genetic analyses.
Leukemia 1992;6(5):370-4.
1992: RG Geissler; Oliver G Ottmann; G Kojouharoff; P Reutzel; Matthias Eder; Dieter Hoelzer; Arnold Ganser
Influence of human recombinant interferon-alpha and interferon-gamma on bone marrow progenitor cells of HIV-positive individuals.
AIDS research and human retroviruses 1992;8(4):521-5.
1992: Arnold Ganser; Gernot Seipelt; Matthias Eder; G Geissler; Oliver G Ottmann; U Hess; Dieter Hoelzer
Treatment of myelodysplastic syndromes with cytokines and cytotoxic drugs.
Seminars in oncology 1992;19(2 Suppl 4):95-101.
1992: G Götz; H J Weh; T A Walter; R Kuse; K Kolbe; G Dölken; K P Hellriegel; Dieter Hoelzer; D K Hossfeld
Clinical and prognostic significance of the Philadelphia chromosome in adult patients with acute lymphoblastic leukemia.
Annals of hematology 1992;64(2):97-100.
1992: C Schardt; Dieter Hoelzer; Arnold Ganser
Presence of more than two rearranged immunoglobulin heavy-chain genes in adult precursor B-cell acute lymphoblastic leukemia.
Annals of hematology 1992;64(2):72-7.
1992: U Hess; Arnold Ganser; H G Schnürch; Gernot Seipelt; Oliver G Ottmann; S Falk; G Schulz; Dieter Hoelzer
Myelokathexis treated with recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF).
British journal of haematology 1992;80(2):254-6.
1992: Dieter Hoelzer; Eckhard Thiel; Wolf-Dieter Ludwig; Helmut Löffler; Thomas Büchner; Mathias Freund; Gerhard Heil; Wolfgang Hiddemann; Georg Maschmeyer; B Völkers
The German multicentre trials for treatment of acute lymphoblastic leukemia in adults. The German Adult ALL Study Group.
Leukemia 1992;6 Suppl 2():175-7.
1992: Dieter Hoelzer
Therapy of acute lymphoblastic leukemia in adults.
Leukemia 1992;6 Suppl 2():132-5.
1992: J Frisch; Arnold Ganser; Dieter Hoelzer; Wolfram Brugger; Lothar Kanz; Roland Mertelsmann; G Schulz
Interleukin-3 and granulocyte-macrophage colony-stimulating factor in combination: clinical implication.
Medical and pediatric oncology. Supplement 1992;2():34-7.
1991: A Lindemann; Arnold Ganser; F Herrmann; J Frisch; Gernot Seipelt; G Schulz; Dieter Hoelzer; Roland Mertelsmann
Biologic effects of recombinant human interleukin-3 in vivo.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(12):2120-7.
1991: RG Geissler; Arnold Ganser; Oliver G Ottmann; G Kojouharoff; P Reutzel; Koen Andries; K Schellekens; Dieter Hoelzer
TIBO R82913, a new HIV-1 inhibiting agent, does not inhibit hematopoietic progenitor cells.
AIDS research and human retroviruses 1991;7(12):1021-3.
1991: Arnold Ganser; Oliver G Ottmann; Gernot Seipelt; U Hess; G Geissler; Rolf Merget; S Falk; A Maurer; Matthias Eder; Dieter Hoelzer
Preclinical and clinical evaluation of interleukin 3.
Behring Institute Mitteilungen 1991;(90):50-61.
1991: Oliver G Ottmann; C C Stella; Matthias Eder; P Reutzel; S Ströcker; Dieter Hoelzer; Arnold Ganser
Regulation of early hematopoiesis in serum-deprived cultures of mafosfamide-treated and untreated CD34-enriched bone marrow cells.
Experimental hematology 1991;19(8):773-8.
1991: Mary M Horowitz; D Messerer; Dieter Hoelzer; Robert Peter Gale; A Neiss; K Atkinson; A J Barrett; Thomas Büchner; Mathias Freund; Gerhard Heil
Chemotherapy compared with bone marrow transplantation for adults with acute lymphoblastic leukemia in first remission.
Annals of internal medicine 1991;115(1):13-8.
1991: Dieter Hoelzer
High-dose chemotherapy in adult acute lymphoblastic leukemia.
Seminars in hematology 1991;28(3 Suppl 4):84-9.
1991: S Lob; Lothar Bergmann; H Müller; Dieter Hoelzer
[Pleomorphic T-cell lymphoma. Its diagnosis and the therapeutic possibilities].
Deutsche medizinische Wochenschrift (1946) 1991;116(25):986-91.
1991: RG Geissler; Oliver G Ottmann; Matthias Eder; G Kojouharoff; Dieter Hoelzer; Arnold Ganser
Effect of recombinant human transforming growth factor beta and tumor necrosis factor alpha on bone marrow progenitor cells of HIV-infected persons.
Annals of hematology 1991;62(5):151-5.
1991: A Lindemann; Arnold Ganser; Dieter Hoelzer; Roland Mertelsmann; F Herrmann
In vivo administration of recombinant human interleukin-3 elicits an acute phase response involving endogenous synthesis of interleukin-6.
European cytokine network 1991;2(3):173-6.
1991: Dieter Hoelzer; Gernot Seipelt; Arnold Ganser
Interleukin 3 alone and in combination with GM-CSF in the treatment of patients with neoplastic disease.
Seminars in hematology 1991;28(2 Suppl 2):17-24.
1991: Gerhard Heil; E Gunsilius; A Raghavachar; Claus R Bartram; Arnold Ganser; E Kurrle; U Aydemir; Helmut Löffler; Dieter Hoelzer; Eckhard Thiel
Ultrastructural demonstration of peroxidase expression in acute unclassified leukemias: correlation to immunophenotype and treatment outcome.
Blood 1991;77(6):1305-12.
1991: S Falk; Gernot Seipelt; Arnold Ganser; Oliver G Ottmann; Dieter Hoelzer; HJ Stutte; K Hübner
Bone marrow findings after treatment with recombinant human interleukin-3.
American journal of clinical pathology 1991;95(3):355-62.
1991: G Kojouharoff; Oliver G Ottmann; H von Briesen; G Geissler; H Rübsamen-Waigmann; Dieter Hoelzer; Arnold Ganser
Infection of granulocyte/monocyte progenitor cells with HIV1.
Research in virology 1991;142(2-3):151-7.
1991: D Messerer; A Neiss; U Aydemir; Dieter Hoelzer; R Arnold
How can disease-free survival of adult ALL patients with or without transplants be compared?
Onkologie 1991;14(1):53-5.
1991: Arnold Ganser; A Lindemann; Gernot Seipelt; Oliver G Ottmann; F Herrmann; Matthias Eder; J Frisch; G Schulz; Roland Mertelsmann; Dieter Hoelzer
Clinical effects of recombinant human interleukin-3.
American journal of clinical oncology 1991;14 Suppl 1():S51-63.
1991: Arnold Ganser; Gernot Seipelt; Dieter Hoelzer
The role of GM-CSF, G-CSF, interleukin-3, and erythropoietin in myelodysplastic syndromes.
American journal of clinical oncology 1991;14 Suppl 1():S34-9.
1991: J Koberda; Lothar Bergmann; Paris S Mitrou; Dieter Hoelzer
High release of tumor necrosis factor alpha, interferon gamma and interleukin-6 by adherent lymphokine-activated killer cells phenotypically derived from T cells.
Journal of cancer research and clinical oncology 1991;117(5):425-30.
1991: Arnold Ganser; A Lindemann; Gernot Seipelt; Oliver G Ottmann; Matthias Eder; F Herrmann; J Frisch; G Schulz; Roland Mertelsmann; Dieter Hoelzer
Recombinant human interleukin-3 in patients with hematopoietic failure.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1991;121():162-72.
1991: Gernot Seipelt; Arnold Ganser; Dieter Hoelzer
Hemopoietic growth factors in the treatment of acute leukemias and myelodysplastic syndromes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1991;121():141-54.
1991: F Herrmann; Roland Mertelsmann; A Lindemann; Oliver G Ottmann; Gernot Seipelt; Wolfgang Oster; Dieter Hoelzer; Arnold Ganser
Clinical use of recombinant human hematopoietic growth factors (GM-CSF, IL-3, EPO) in patients with myelodysplastic syndrome.
Biotechnology therapeutics 1991;2(3-4):299-311.
1990: Oliver G Ottmann; Arnold Ganser; Gernot Seipelt; Matthias Eder; G Schulz; Dieter Hoelzer
Effects of recombinant human interleukin-3 on human hematopoietic progenitor and precursor cells in vivo.
Blood 1990;76(8):1494-502.
1990: Arnold Ganser; A Lindemann; Gernot Seipelt; Oliver G Ottmann; F Herrmann; Matthias Eder; J Frisch; G Schulz; Roland Mertelsmann; Dieter Hoelzer
Effects of recombinant human interleukin-3 in patients with normal hematopoiesis and in patients with bone marrow failure.
Blood 1990;76(4):666-76.
1990: Matthias Eder; Oliver G Ottmann; T E Hansen-Hagge; C R Bartram; S Gillis; Dieter Hoelzer; Arnold Ganser
Effects of recombinant human IL-7 on blast cell proliferation in acute lymphoblastic leukemia.
Leukemia 1990;4(8):533-40.
1990: Dieter Hoelzer
Change in treatment strategies for adult acute lymphoblastic leukemia (ALL) according to prognostic factors and minimal residual disease.
Bone marrow transplantation 1990;6 Suppl 1():66-70.
1990: Arnold Ganser; Oliver G Ottmann; H von Briesen; B Völkers; H Rübsamen-Waigmann; Dieter Hoelzer
Changes in the haematopoietic progenitor cell compartment in the acquired immunodeficiency syndrome.
Research in virology 1990;141(2):185-93.
1990: Dieter Hoelzer; Arnold Ganser; Oliver G Ottmann; K Höffken; R Becher; D Lutz; O Krieger; V Diehl; B Lathan; M A Boogaerts
Effect of treatment with rhGM-CSF and low-dose cytosine arabinoside on leukemic blast cells in patients with myelodysplastic syndromes.
Haematology and blood transfusion 1990;33():763-9.
1990: Gerhard Ehninger; E Fackler-Schwalbe; Mathias Freund; Gerhard Heil; M Henke; Dieter Hoelzer; R Hoffmann; E Kurrle; H Link; A Lösch
Combination of mitoxantrone and etoposide in patients aged over 60 years with untreated acute myelogenous leukemia.
Haematology and blood transfusion 1990;33():316-7.
1990: E Kurrle; Gerhard Ehninger; E Fackler-Schwalbe; Mathias Freund; Gerhard Heil; Dieter Hoelzer; H Link; B Löffler; A Lösch; Paris S Mitrou
Consolidation therapy with high-dose cytosine arabinoside: experiences of a prospective study in acute myeloid leukemia.
Haematology and blood transfusion 1990;33():254-60.
1990: Gerhard Heil; E Gunsilius; A Raghavachar; E Kurrle; Dieter Hoelzer; Hermann Heimpel; Eckhard Thiel
Correlation between the expression of myelomonocytic surface antigens and ultrastructural demonstration of early myeloperoxidase expression in null-AL(L) cells.
Haematology and blood transfusion 1990;33():67-71.
1990: Gernot Seipelt; Oliver G Ottmann; Arnold Ganser; Matthias Eder; A Lindemann; S Falk; HJ Stutte; K Hübner; Roland Mertelsmann; Dieter Hoelzer
[In vitro and in vivo effects of recombinant human interleukin-3 on hematopoietic progenitor cells].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1990;74():116-9.
1990: S Falk; Gernot Seipelt; Arnold Ganser; Dieter Hoelzer; HJ Stutte; K Hübner
[Effects on bone marrow during stimulation of hematopoietic stem cells with recombinant human interleukin-3].
Verhandlungen der Deutschen Gesellschaft für Pathologie 1990;74():111-5.
1990: Rolf Merget; A B Maurer; U Koch; Arnold Ganser; Oliver G Ottmann; Gerhard Schultze-Werninghaus; Gernot Seipelt; W Zachgo; Dieter Hoelzer; J Meier-Sydow
Histamine release from basophils after in vivo application of recombinant human interleukin-3 in man.
International archives of allergy and applied immunology 1990;92(4):366-74.
1989: Arnold Ganser; Oliver G Ottmann; H Erdmann; G Schulz; Dieter Hoelzer
The effect of recombinant human granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity in chronic severe neutropenia.
Annals of internal medicine 1989;111(11):887-92.
1989: Arnold Ganser; M Bergmann; B Völkers; P Grützmacher; P Scigalla; Dieter Hoelzer
In vivo effects of recombinant human erythropoietin on circulating human hemopoietic progenitor cells.
Experimental hematology 1989;17(5):433-5.
1989: B Völkers; Arnold Ganser; J Greher; C C Stella; Dieter Hoelzer
[Effect of tumor necrosis factor on human hematopoietic precursor cells].
Onkologie 1989;12(3):109-15.
1989: Arnold Ganser; J Greher; B Völkers; Schlomo Staszewski; Dieter Hoelzer
Inhibitory effect of azidothymidine, 2'-3'-dideoxyadenosine, and 2'-3'-dideoxycytidine on in vitro growth of hematopoietic progenitor cells from normal persons and from patients with AIDS.
Experimental hematology 1989;17(4):321-5.
1989: Arnold Ganser; Oliver G Ottmann; G Schulz; Dieter Hoelzer
Recombinant human granulocyte-macrophage colony-stimulating factor and low-dose cytosine arabinoside in patients with myelodysplastic syndrome. A pilot study.
Onkologie 1989;12(1):13-5.
1989: Dieter Hoelzer
Which factors influence the different outcome of therapy in adults and children with ALL?
Bone marrow transplantation 1989;4 Suppl 1():98-100.
1989: Arnold Ganser; B Völkers; J Greher; Oliver G Ottmann; F Walther; R Becher; Lothar Bergmann; G Schulz; Dieter Hoelzer
Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase I/II trial.
Blood 1989;73(1):31-7.
1988: C Carlo-Stella; Mario Cazzola; Arnold Ganser; Gaetano Bergamaschi; Paolo Pedrazzoli; Dieter Hoelzer; Edoardo Ascari
Synergistic antiproliferative effect of recombinant interferon-gamma with recombinant interferon-alpha on chronic myelogenous leukemia hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM).
Blood 1988;72(4):1293-9.
1988: S Grünwald; Pablo Hernáiz Driever; Dieter Hoelzer; D Drahovsky
Reduced methyl group acceptance of 1-beta-D-arabinofuranosylcytosine-containing DNA polymers.
Biochimica et biophysica acta 1988;950(3):366-73.
1988: Arnold Ganser; B Völkers; J Greher; Dieter Hoelzer
Effect of recombinant human granulocyte-macrophage colony-stimulating factor on the hemopoietic progenitor cells from patients with AIDS.
Behring Institute Mitteilungen 1988;(83):284-8.
1988: Dieter Hoelzer; Arnold Ganser; J Greher; B Völkers; F Walther
Phase I/II study with GM-CSF in patients with myelodysplastic syndromes.
Behring Institute Mitteilungen 1988;(83):134-8.
1988: E Kurrle; Gerhard Ehninger; Mathias Freund; Gerhard Heil; Dieter Hoelzer; H Link; Paris S Mitrou; S Ohl; W Queisser; G Schlimok
A multicentre study on intensive induction and consolidation therapy in acute myelogenous leukaemia.
Blut 1988;56(5):233-6.
1988: Ernst D Kreuser; W D Hetzel; W Heit; Dieter Hoelzer; E Kurrle; N Xiros; Hermann Heimpel
Reproductive and endocrine gonadal functions in adults following multidrug chemotherapy for acute lymphoblastic or undifferentiated leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1988;6(4):588-95.
1988: Arnold Ganser; B Völkers; P Scigalla; Dieter Hoelzer
Effect of human recombinant erythropoietin on human hemopoietic progenitor cells in vitro.
Klinische Wochenschrift 1988;66(6):236-40.
1988: Arnold Ganser; B Völkers; J Greher; F Walther; Dieter Hoelzer
Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase-I/II trial.
Onkologie 1988;11(1):53-5.
1988: E Kurrle; Gerhard Ehninger; Mathias Freund; Gerhard Heil; Dieter Hoelzer; H Link; Paris S Mitrou; S Ohl; W Queisser; G Schlimok
[Induction and intensive combined therapy of acute myeloid leukemia in adults].
Onkologie 1988;11(1):5-9.
1988: Dieter Hoelzer; Eckhard Thiel; Helmut Löffler; Thomas Büchner; Arnold Ganser; Gerhard Heil; E Kurrle; H Heimpel; P Koch; T Lipp
[Intensive combined therapy for high-risk ALL patients].
Onkologie 1988;11(1):18-24.
1988: Arnold Ganser; M Bergmann; B Völkers; P Grützmacher; Dieter Hoelzer
In vitro and in vivo effects of recombinant human erythropoietin on human hemopoietic progenitor cells.
Contributions to nephrology 1988;66():123-30.
1988: Dieter Hoelzer
Cytobiology and clinical findings of myelodysplastic syndromes.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1988;106():172-9.
1988: C Carlo Stella; Mario Cazzola; Arnold Ganser; Gaetano Bergamaschi; F Meloni; Paolo Pedrazzoli; Paolo Bernasconi; Rosangela Invernizzi; Dieter Hoelzer; Edoardo Ascari
Recombinant gamma-interferon induces in vitro monocytic differentiation of blast cells from patients with acute nonlymphocytic leukemia and myelodysplastic syndromes.
Leukemia 1988;2(1):55-9.
1988: Dieter Hoelzer; Arnold Ganser; B Völkers; J Greher; F Walther
In vitro and in vivo action of recombinant human GM-CSF (rhGM-CSF) in patients with myelodysplastic syndromes.
Blood cells 1988;14(2-3):551-9.
1988: Gerhard Heil; Arnold Ganser; A Raghavachar; E Kurrle; W Heit; Dieter Hoelzer; Hermann Heimpel
Induction of myeloperoxidase in five cases of acute unclassified leukaemia.
British journal of haematology 1988;68(1):23-32.
1987: Arnold Ganser; C Carlo-Stella; J Greher; B Völkers; Dieter Hoelzer
Effect of recombinant interferons alpha and gamma on human bone marrow-derived megakaryocytic progenitor cells.
Blood 1987;70(4):1173-9.
1987: C Carlo-Stella; Mario Cazzola; A Gasner; Giovanni Barosi; L Dezza; F Meloni; Paolo Pedrazzoli; Dieter Hoelzer; Edoardo Ascari
Effects of recombinant alpha and gamma interferons on the in vitro growth of circulating hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) from patients with myelofibrosis with myeloid metaplasia.
Blood 1987;70(4):1014-9.
1987: Dieter Hoelzer; Eckhard Thiel; Helmut Löffler; Thomas Büchner; Arnold Ganser; Gerhard Heil; E Kurrle; H Heimpel; P Koch; T Lipp
Teniposide (VM-26) and cytosine arabinoside as consolidation therapy in adult high-risk patients with acute lymphoblastic leukemia.
Seminars in oncology 1987;14(2 Suppl 1):92-7.
1987: D Messerer; J Hasford; Dieter Hoelzer; A Neiss; T Zwingers
Pitfalls in the evaluation of prognostic factors.
Haematology and blood transfusion 1987;30():308-12.
1987: Arnold Ganser; C Carlo Stella; B Völkers; K H Brodt; Eilke B Helm; Dieter Hoelzer
Loss of hematopoietic progenitor cells CFU-GEMM, BFU-E, CFU-Mk, and CFU-GM in the acquired immunodeficiency syndrome (AIDS)?
Haematology and blood transfusion 1987;31():175-6.
1985: Dieter Hoelzer; Eckhard Thiel; Helmut Löffler; H Bodenstein; Thomas Büchner; R Engelhardt; Arnold Ganser; D Messerer; H Rühl; T Zwingers
Risk groups in a multicenter pilot study for treatment of acute lymphoblastic and acute undifferentiated leukemia in adults.
Haematology and blood transfusion 1985;29():48-50.
1983: Dieter Hoelzer; Eckhard Thiel; Helmut Löffler; H Bodenstein; Thomas Büchner; D Messerer
Multicentre pilot study for therapy of acute lymphoblastic and acute undifferentiated leukemia in adults.
Haematology and blood transfusion 1983;28():36-40.

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