FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Achim Hoerauf

Research Profile

Living Beings

Disorders

Chemicals & Drugs

Phenomena

Symbiosis

Geographic Areas

Ghana

Co-author Network

Publications

TOP 3
Jennifer Vollmer; Achim Hoerauf; Kelly L Johnston; Karen Jülicher; Hans-Georg Sahl; Andrea Schiefer; Tanja Schneider; Mark J Taylor; Kenneth Pfarr
Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes.
Christian S Lentz; Günter Mayer; Björn Niebel; Michael Famulok; Victoria Halls; Jeffrey S Hannam; Achim Hoerauf; Uta Strübing; Kenneth Pfarr
A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro.
Sabine Mand; Yeboah Marfo-Debrekyei; Sabine Specht; Mark Taylor; Ohene Adjei; Linda Batsa; Aurea Belda-Domene; Alexander Yaw Debrah; Rolf Fimmers; Ute Klarmann; Alexander Kwarteng; Achim Hoerauf
Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Achim Hoerauf (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Jennifer Vollmer; Achim Hoerauf; Kelly L Johnston; Karen Jülicher; Hans-Georg Sahl; Andrea Schiefer; Tanja Schneider; Mark J Taylor; Kenneth Pfarr
Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes.
International journal of medical microbiology : IJMM 2013;303(3):140-9.
2013: Christian S Lentz; Günter Mayer; Björn Niebel; Michael Famulok; Victoria Halls; Jeffrey S Hannam; Achim Hoerauf; Uta Strübing; Kenneth Pfarr
A selective inhibitor of heme biosynthesis in endosymbiotic bacteria elicits antifilarial activity in vitro.
Chemistry & biology 2013;20(2):177-87.
2012: Sabine Mand; Yeboah Marfo-Debrekyei; Sabine Specht; Mark Taylor; Ohene Adjei; Linda Batsa; Aurea Belda-Domene; Alexander Yaw Debrah; Rolf Fimmers; Ute Klarmann; Alexander Kwarteng; Achim Hoerauf
Doxycycline improves filarial lymphedema independent of active filarial infection: a randomized controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012;55(5):621-30.
2012: Sabine Specht; Matthew D Taylor; Judith E Allen; Marieke A Hoeve; Roland Lang; Achim Hoerauf
Over expression of IL-10 by macrophages overcomes resistance to murine filariasis.
Experimental parasitology 2012;132(1):90-6.
2012: Hidayat Hussain; Salem R Sarite; Sabine Specht; Achim Hoerauf; Karsten Krohn
New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain.
European journal of medicinal chemistry 2012;54():936-42.
2012: Andrea Schiefer; Alexander Schmitz; Sabine Specht; Dmitry G Vassylyev; Achim Hoerauf; Kelly L Johnston; Gabriele M König; Christine Lämmer; Till F Schäberle; Kenneth Pfarr
Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo.
The Journal of infectious diseases 2012;206(2):249-57.
2012: Kathrin Arndts; Linda Batsa; Alexander Yaw Debrah; Susanne Deininger; Christian Epp; Ute Klarmann; Alexander Kwarteng; Laura E Layland; Sabine Mand; Sabine Specht; Mark Taylor; Ohene Adjei; Tomabu Adjobimey; Achim Hoerauf
Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti.
PLoS neglected tropical diseases 2012;6(4):e1611.
2012: Sebastian Ziewer; Odile Bain; Bettina Dubben; Achim Hoerauf; Wolfgang H Hoffmann; Marc P Hübner; Coralie Martin; Sabine Specht
Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis.
PLoS neglected tropical diseases 2012;6(3):e1558.
2012: Nicholas Tendongfor; Samuel Wanji; Peter Enyong; Mathias Eyong Esum; Klaus I Matthaei; Julius C Ngwa; Sabine Specht; Achim Hoerauf
The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization.
Parasites & vectors 2012;5():43.
2012: Anna Albers; Peter Enyong; Mathias Eyong Esum; Achim Hoerauf; Ute Klarmann; Nicholas Tendongfor; Samuel Wanji; Kenneth Pfarr
Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host.
Parasites & vectors 2012;5():12.
2011: Alexander Yaw Debrah; Achim Hoerauf; Sabine Mand; Peter Nürnberg; Ohene Adjei; Anna Albers; Linda Batsa; Mohammad R Toliat; Kenneth Pfarr
Transforming growth factor-β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis.
Human immunology 2011;72(11):1143-8.
2011: Sabine Mand; Sunny Mante; Yeboah Marfo-Debrekyei; Ute Klarmann; Alexander Kwarteng; Ohene Adjei; Linda Batsa; Alexander Yaw Debrah; Achim Hoerauf
The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis.
Acta tropica 2011;120 Suppl 1():S23-32.
2011: Hidayat Hussain; Achim Hoerauf; Michael Saeftel; Salem R Sarite; Barbara Schulz; Sabine Specht; Karsten Krohn
A new class of phenazines with activity against a chloroquine resistant Plasmodium falciparum strain and antimicrobial activity.
Journal of medicinal chemistry 2011;54(13):4913-7.
2011: Francesca Tamarozzi; Katrin Gentil; Alice Halliday; Achim Hoerauf; Eric Pearlman; Mark J Taylor
Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment.
Clinical microbiology reviews 2011;24(3):459-68.
2011: Achim Hoerauf; Sabine Mand; Kenneth Pfarr; Alexander Yaw Debrah; Sabine Specht
Filariasis in Africa--treatment challenges and prospects.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2011;17(7):977-85.
2011: Norbert Brattig; Paul Racz; Achim Hoerauf; Dietrich W Büttner
Strong expression of TGF-beta in human host tissues around subcutaneous Dirofilaria repens.
Parasitology research 2011;108(6):1347-54.
2011: Sabine Specht; Jutta K Frank; Judith Alferink; Bettina Dubben; Laura E Layland; Gaelle Denece; Odile Bain; Irmgard Förster; Carsten J Kirschning; Coralie Martin; Achim Hoerauf
CCL17 controls mast cells for the defense against filarial larval entry.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(8):4845-52.
2011: Oliver Liesenfeld; Maria M Mota; Melba Muñoz; Iana Parvanova; Gaby Reichmann; Michael Saeftel; Sabine Specht; Olaf Utermöhlen; Friederike D Von Loewenich; Esther Von Stebut; Ari Waisman; Jens Zerrahn; Toni Aebischer; Christian Bogdan; Thorsten Buch; Seong-Ji Han; Frederik Heinrich; Achim Hoerauf; Frank Kaiser; Stefan H E Kaufmann; S Könen-Waisman; Jonathan C Howard
The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.
PloS one 2011;6(6):e20568.
2011: Alexander Yaw Debrah; Ohene Adjei; Anna Albers; Linda Batsa; Ute Klarmann; Sabine Mand; Yeboah Marfo-Debrekyei; Kenneth Pfarr; Sabine Specht; Achim Hoerauf
Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline.
Journal of parasitology research 2011;2011():201617.
2011: S Korten; Achim Hoerauf; J T Kaifi; Dietrich W Büttner
Low levels of transforming growth factor-beta (TGF-beta) and reduced suppression of Th2-mediated inflammation in hyperreactive human onchocerciasis.
Parasitology 2011;138(1):35-45.
2010: Mark J Taylor; Achim Hoerauf; Moses J Bockarie
Lymphatic filariasis and onchocerciasis.
Lancet 2010;376(9747):1175-85.
2010: Björn Niebel; Christian Lentz; Monika Pofahl; Günter Mayer; Achim Hoerauf; Kenneth Pfarr; Michael Famulok
ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(36):11100-7.
2010: Tomabu Adjobimey; Achim Hoerauf
Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation.
Annals of tropical medicine and parasitology 2010;104(6):455-64.
2010: Uta Strübing; Richard Lucius; Achim Hoerauf; Kenneth Pfarr
Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes.
International journal for parasitology 2010;40(10):1193-202.
2010: Norbert Brattig; Klara Tenner-Racz; Simone Korten; Achim Hoerauf; Dietrich W Büttner
Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda).
Parasitology research 2010;107(3):657-66.
2010: Sabine Specht; Daniel Fernández Ruiz; Bettina Dubben; Susanne Deininger; Achim Hoerauf
Filaria-induced IL-10 suppresses murine cerebral malaria.
Microbes and infection / Institut Pasteur 2010;12(8-9):635-42.
2010: Simone Korten; Jussuf T Kaifi; Dietrich W Büttner; Achim Hoerauf
Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia.
Microbes and infection / Institut Pasteur 2010;12(7):555-64.
2010: Bettina Langhans; Ingrid Braunschweiger; Simone Arndt; Wibke Schulte; Judith Sedaminou Satoguina; Laura E Layland; Natascha Vidovic; Achim Hoerauf; Johannes Oldenburg; Tilman Sauerbruch; Ulrich Spengler
Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C.
Clinical science (London, England : 1979) 2010;119(2):97-109.
2010: Norbert Brattig; Achim Hoerauf; P U Fischer; Eva Liebau; Claudio Bandi; Alexander Yaw Debrah; M Büttner; Dietrich W Büttner
Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.
Parasitology 2010;137(5):841-54.
2010: Laura E Layland; Jörg Mages; Christoph Loddenkemper; Achim Hoerauf; Hermann Wagner; Roland Lang; Clarissa U Prazeres Da Costa
Pronounced phenotype in activated regulatory T cells during a chronic helminth infection.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(2):713-24.
2010: Joseph D Turner; Nicholas Tendongfor; Mathias Esum; Kelly L Johnston; R Stuart Langley; Louise Ford; Brian Faragher; Sabine Specht; Sabine Mand; Achim Hoerauf; Peter Enyong; Samuel Wanji; Mark J Taylor
Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial.
PLoS neglected tropical diseases 2010;4(4):e660.
2009: Sabine Specht; Achim Hoerauf; Ohene Adjei; Alexander Yaw Debrah; Dietrich W Büttner
Newly acquired Onchocerca volvulus filariae after doxycycline treatment.
Parasitology research 2009;106(1):23-31.
2009: Kenneth Pfarr; Alexander Yaw Debrah; Sabine Specht; Achim Hoerauf
Filariasis and lymphoedema.
Parasite immunology 2009;31(11):664-72.
2009: Norbert Brattig; Arline Schwohl; Achim Hoerauf; Dietrich W Büttner
Identification of the lipid mediator prostaglandin E2 in tissue immune cells of humans infected with the filaria Onchocerca volvulus.
Acta tropica 2009;112(2):231-5.
2009: Sabine Mand; Kenneth Pfarr; Prakash K Sahoo; Ashok K Satapathy; Sabine Specht; Ute Klarmann; Alexander Yaw Debrah; Balachandran Ravindran; Achim Hoerauf
Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine.
The American journal of tropical medicine and hygiene 2009;81(4):702-11.
2009: Beate Henrichfreise; Andrea Schiefer; Tanja Schneider; Edith Nzukou; Christina Poellinger; Theo-Julian Hoffmann; Kelly L Johnston; Katja Moelleken; Imke Wiedemann; Kenneth Pfarr; Achim Hoerauf; Hans-Georg Sahl
Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed?
Molecular microbiology 2009;73(5):913-23.
2009: Simone Korten; Dietrich W Büttner; Christel Schmetz; Achim Hoerauf; Sabine Mand; Norbert Brattig
The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta).
Parasitology research 2009;105(3):731-41.
2009: Alexander Yaw Debrah; Sabine Mand; Yeboah Marfo-Debrekyei; Linda Batsa; Kenneth Pfarr; Bernard Lawson; Mark Taylor; Ohene Adjei; Achim Hoerauf
Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline.
The American journal of tropical medicine and hygiene 2009;80(6):956-63.
2009: Sabine Specht; Achim Hoerauf
Filarial parasites in the postgenomic era.
Expert review of anti-infective therapy 2009;7(2):189-92.
2009: Daniel Fernández Ruiz; Bettina Dubben; Michael Saeftel; Elmar Endl; Susanne Deininger; Achim Hoerauf; Sabine Specht
Filarial infection induces protection against P. berghei liver stages in mice.
Microbes and infection / Institut Pasteur 2009;11(2):172-80.
2009: Tarik Attout; Achim Hoerauf; Gaëlle Dénécé; Alexander Yaw Debrah; Yeboah Marfo-Debrekyei; Michel Boussinesq; Samuel Wanji; Valérie Martinez; Sabine Mand; Ohene Adjei; Odile Bain; Sabine Specht; Coralie Martin
Lymphatic vascularisation and involvement of Lyve-1+ macrophages in the human onchocerca nodule.
PloS one 2009;4(12):e8234.
2009: Samuel Wanji; Nicholas Tendongfor; Theolbald Nji; Mathias Esum; Julious N Che; Armand Nkwescheu; Fifen Alassa; Geremy Kamnang; Peter A Enyong; Mark J Taylor; Achim Hoerauf; David W Taylor
Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon.
Parasites & vectors 2009;2(1):39.
2009: Ingrid Reiter-Owona; Beate Grüner; Matthias Frosch; Achim Hoerauf; Peter Kern; Dennis Tappe
Serological confirmatory testing of alveolar and cystic echinococcosis in clinical practice: results of a comparative study with commercialized and in-house assays.
Clinical laboratory 2009;55(1-2):41-8.
2009: Mark J Taylor; Kwablah Awadzi; María-Gloria Basáñez; Nana Biritwum; Daniel Boakye; Boakye A Boatin; Moses Bockarie; Thomas S Churcher; Alexander Yaw Debrah; Geoffrey Edwards; Achim Hoerauf; Sabine Mand; Graham Matthews; Mike Osei-Atweneboana; Roger K Prichard; Samuel Wanji; Ohene Adjei
Onchocerciasis Control: Vision for the Future from a Ghanian perspective.
Parasites & vectors 2009;2(1):7.
2009: Achim Hoerauf; Sabine Specht; Yeboah Marfo-Debrekyei; Marcelle Büttner; Alexander Yaw Debrah; Sabine Mand; Linda Batsa; Norbert Brattig; Peter Konadu; Claudio Bandi; Rolf Fimmers; Ohene Adjei; Dietrich W Büttner
Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus.
Parasitology research 2009;104(2):437-47.
2008: Achim Hoerauf
Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis.
Current opinion in infectious diseases 2008;21(6):673-81.
2008: Judith Sedaminou Satoguina; Tomabu Adjobimey; Kathrin Arndts; Jochen Hoch; Johannes Oldenburg; Laura E Layland; Achim Hoerauf
Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta.
European journal of immunology 2008;38(11):3101-13.
2008: Sabine Specht; Sabine Mand; Yeboah Marfo-Debrekyei; Alexander Yaw Debrah; Peter Konadu; Ohene Adjei; Dietrich W Büttner; Achim Hoerauf
Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus.
Parasitology research 2008;103(6):1303-9.
2008: Achim Hoerauf; Sabine Specht; Marcelle Büttner; Kenneth Pfarr; Sabine Mand; Rolf Fimmers; Yeboah Marfo-Debrekyei; Peter Konadu; Alexander Yaw Debrah; Claudio Bandi; Norbert W Brattig; Anna Albers; John Larbi; Linda Batsa; Mark J Taylor; Ohene Adjei; Dietrich W Büttner
Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study.
Medical microbiology and immunology 2008;197(3):295-311.
2008: Achim Hoerauf; Yeboah Marfo-Debrekyei; Marcelle Büttner; Alexander Yaw Debrah; Peter Konadu; Sabine Mand; Ohene Adjei; Dietrich W Büttner
Effects of 6-week azithromycin treatment on the Wolbachia endobacteria of Onchocerca volvulus.
Parasitology research 2008;103(2):279-86.
2008: Sridhar Arumugam; Kenneth Pfarr; Achim Hoerauf
Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms.
International journal for parasitology 2008;38(8-9):981-7.
2008: Sabine Mand; Dietrich W Büttner; Achim Hoerauf
Bancroftian filariasis--absence of Wolbachia after doxycycline treatment.
The American journal of tropical medicine and hygiene 2008;78(6):854-5.
2008: Kenneth Pfarr; U Heider; C Schmetz; Dietrich W Büttner; Achim Hoerauf
The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia.
Parasitology 2008;135(4):529-38.
2008: Simone Korten; Marlis Badusche; Dietrich W Büttner; Achim Hoerauf; Norbert W Brattig; Bernhard Fleischer
Natural death of adult Onchocerca volvulus and filaricidal effects of doxycycline induce local FOXP3+/CD4+ regulatory T cells and granzyme expression.
Microbes and infection / Institut Pasteur 2008;10(3):313-24.
2008: Anna-Maria Dittrich; Annika Erbacher; Sabine Specht; Felix Diesner; Martin Krokowski; Anzhela Avagyan; Philippe Stock; Birgit Ahrens; Wolfgang H Hoffmann; Achim Hoerauf; Eckard Hamelmann
Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1792-9.
2008: Tim Goebel; Daniela Ulmer; Holger Projahn; Jessica Kloeckner; Eberhard Heller; Melanie Glaser; Alicia Ponte-Sucre; Sabine Specht; Salem Ramadan Sarite; Achim Hoerauf; Annette Kaiser; Ilona Hauber; Joachim Hauber; Ulrike Holzgrabe
In search of novel agents for therapy of tropical diseases and human immunodeficiency virus.
Journal of medicinal chemistry 2008;51(2):238-50.
2007: Alexander Yaw Debrah; Sabine Mand; Yeboah Marfo-Debrekyei; Linda Batsa; Kenneth Pfarr; Marcelle Buttner; Ohene Adjei; Dietrich Buttner; Achim Hoerauf
Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti.
Tropical medicine & international health : TM & IH 2007;12(12):1433-41.
2007: Alexander Yaw Debrah; Sabine Mand; Mohammad R Toliat; Yeboah Marfo-Debrekyei; Linda Batsa; Peter Nürnberg; Bernard Lawson; Ohene Adjei; Achim Hoerauf; Kenneth Pfarr
Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis.
The American journal of tropical medicine and hygiene 2007;77(4):601-8.
2007: Kenneth Pfarr; Jeremy Foster; Barton Slatko; Achim Hoerauf; Jonathan Eisen
On the taxonomic status of the intracellular bacterium Wolbachia pipientis: should this species name include the intracellular bacteria of filarial nematodes?
International journal of systematic and evolutionary microbiology 2007;57(Pt 8):1677-8.
2007: Sabine Specht; Achim Hoerauf
Does helminth elimination promote or prevent malaria?
Lancet 2007;369(9560):446-7.
2007: Kenneth Pfarr; Achim Hoerauf
A niche for Wolbachia.
Trends in parasitology 2007;23(1):5-7.
2006: A Kaiser; D Ulmer; T Goebel; Ulrike Holzgrabe; Michael Saeftel; Achim Hoerauf
Inhibition of hypusine biosynthesis in plasmodium: a possible, new strategy in prevention and therapy of malaria.
Mini reviews in medicinal chemistry 2006;6(11):1231-41.
2006: Alexander Yaw Debrah; Sabine Mand; Sabine Specht; Yeboah Marfo-Debrekyei; Linda Batsa; Kenneth Pfarr; John Larbi; Bernard Lawson; Mark Taylor; Ohene Adjei; Achim Hoerauf
Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis.
PLoS pathogens 2006;2(9):e92.
2006: Sabine Mand; Sabine Specht; H Zahner; Achim Hoerauf
Ultrasonography in filaria-infected rodents: detection of adult Litomosoides sigmodontis and Brugia malayi filariae.
Tropical medicine & international health : TM & IH 2006;11(9):1382-7.
2006: Sabine Mand; T Supali; J Djuardi; S Kar; B Ravindran; Achim Hoerauf
Detection of adult Brugia malayi filariae by ultrasonography in humans in India and Indonesia.
Tropical medicine & international health : TM & IH 2006;11(9):1375-81.
2006: Sabine Specht; Michael Saeftel; Manuela Arndt; Elmar Endl; Bettina Dubben; Nancy A Lee; James J Lee; Achim Hoerauf
Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection.
Infection and immunity 2006;74(9):5236-43.
2006: Ulrike Heider; Mark Blaxter; Achim Hoerauf; Kenneth Pfarr
Differential display of genes expressed in the filarial nematode Litomosoides sigmodontis reveals a putative phosphate permease up-regulated after depletion of Wolbachia endobacteria.
International journal of medical microbiology : IJMM 2006;296(4-5):287-99.
2006: Michael Saeftel; Ramadan Salem Sarite; Tujo Njuguna; Ulrike Holzgrabe; Daniela Ulmer; Achim Hoerauf; Annette Kaiser
Piperidones with activity against Plasmodium falciparum.
Parasitology research 2006;99(3):281-6.
2006: Kenneth Pfarr; Ulrike Heider; Achim Hoerauf
RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype.
International journal for parasitology 2006;36(6):661-9.
2006: Joseph D Turner; Sabine Mand; Alexander Yaw Debrah; Johannes Muehlfeld; Kenneth Pfarr; Helen F McGarry; Ohene Adjei; Mark J Taylor; Achim Hoerauf
A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006;42(8):1081-9.
2006: Sabine Specht; Sandra Arriens; Achim Hoerauf
Induction of chronic colitis in IL-10 deficient mice requires IL-4.
Microbes and infection / Institut Pasteur 2006;8(3):694-703.
2006: Kenneth Oben Eyong; Gabriel Ngosong Folefoc; Victor Kuete; Véronique Penlap Beng; Karsten Krohn; Hidayat Hussain; Augustin E Nkengfack; Michael Saeftel; Salem Ramadan Sarite; Achim Hoerauf
Newbouldiaquinone A: A naphthoquinone-anthraquinone ether coupled pigment, as a potential antimicrobial and antimalarial agent from Newbouldia laevis.
Phytochemistry 2006;67(6):605-9.
2006: Kenneth Pfarr; Achim Hoerauf
Antibiotics which target the Wolbachia endosymbionts of filarial parasites: a new strategy for control of filariasis and amelioration of pathology.
Mini reviews in medicinal chemistry 2006;6(2):203-10.
2006: James Njuguna; Marwa Nassar; Achim Hoerauf; Annette E Kaiser
Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax.
BMC microbiology 2006;6():91.
2006: Alexander Yaw Debrah; Sabine Mand; Yeboah Marfo-Debrekyei; John Larbi; Ohene Adjei; Achim Hoerauf
Assessment of microfilarial loads in the skin of onchocerciasis patients after treatment with different regimens of doxycycline plus ivermectin.
Filaria journal 2006;5():1.
2005: Achim Hoerauf; Judith Sedaminou Satoguina; Michael Saeftel; Sabine Specht
Immunomodulation by filarial nematodes.
Parasite immunology 2005;27(10-11):417-29.
2005: Mark J Taylor; Williams H Makunde; Helen F McGarry; Joseph D Turner; Sabine Mand; Achim Hoerauf
Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial.
Lancet 2005;365(9477):2116-21.
2005: Simon A Babayan; Tarik Attout; Sabine Specht; Achim Hoerauf; Georges Snounou; Laurent Rénia; Masataka Korenaga; Odile Bain; Coralie Martin
Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis.
Medical microbiology and immunology 2005;194(3):151-62.
2005: Judith Sedaminou Satoguina; Esther Weyand; John Larbi; Achim Hoerauf
T regulatory-1 cells induce IgG4 production by B cells: role of IL-10.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4718-26.
2005: Kenneth Pfarr; Achim Hoerauf
The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicine.
PLoS medicine 2005;2(4):e110.
2005: Tarik Attout; Simon A Babayan; Achim Hoerauf; D W Taylor; W J Kozek; Coralie Martin; Odile Bain
Blood-feeding in the young adult filarial worms Litomosoides sigmodontis.
Parasitology 2005;130(Pt 4):421-8.
2005: Andreas Lang; Dirk Benke; Frank Eitner; Daniel Engel; Svenja Ehrlich; Minka Breloer; Emma E Hamilton-Williams; Sabine Specht; Achim Hoerauf; Jürgen Floege; Arne von Bonin; Christian Kurts
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
Journal of the American Society of Nephrology : JASN 2005;16(2):383-91.
2005: Mark J Taylor; Claudio Bandi; Achim Hoerauf
Wolbachia bacterial endosymbionts of filarial nematodes.
Advances in parasitology 2005;60():245-84.
2004: Sabine Specht; Lars Volkmann; Tom Wynn; Achim Hoerauf
Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis.
Infection and immunity 2004;72(11):6287-93.
2004: Sabine Mand; Alexander Yaw Debrah; Linda Batsa; Ohene Adjei; Achim Hoerauf
Reliable and frequent detection of adult Wuchereria bancrofti in Ghanaian women by ultrasonography.
Tropical medicine & international health : TM & IH 2004;9(10):1111-4.
2004: Norbert W Brattig; Chiara Bazzocchi; Carsten J Kirschning; Norbert Reiling; Dietrich W Büttner; Fabrizio Ceciliani; Frank Geisinger; Hubertus Hochrein; Martin Ernst; Hermann Wagner; Claudio Bandi; Achim Hoerauf
The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):437-45.
2004: Jan ter Meulen; Marlis Badusche; Judith Sedaminou Satoguina; Thomas Strecker; Oliver Lenz; Cornelius Loeliger; Mohamed Sakho; Kekoura Koulemou; Lamine Koivogui; Achim Hoerauf
Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized by Lassa virus-specific human CD4+ T-cell clones.
Virology 2004;321(1):134-43.
2004: Michael Saeftel; Andreas Krueger; Sandra Arriens; Volker T Heussler; Paul Racz; Bernhard Fleischer; Frank Brombacher; Achim Hoerauf
Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice.
Infection and immunity 2004;72(1):322-31.
2003: Michael Saeftel; Manuela Arndt; Sabine Specht; Lars Volkmann; Achim Hoerauf
Synergism of gamma interferon and interleukin-5 in the control of murine filariasis.
Infection and immunity 2003;71(12):6978-85.
2003: David H Molyneux; Mark Bradley; Achim Hoerauf; Dominique Kyelem; Mark J Taylor
Mass drug treatment for lymphatic filariasis and onchocerciasis.
Trends in parasitology 2003;19(11):516-22.
2003: Achim Hoerauf; Sabine Mand; Kerstin Fischer; Thomas F Kruppa; Yeboah Marfo-Debrekyei; Alexander Yaw Debrah; Kenneth Pfarr; Ohene Adjei; Dietrich W Büttner
Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production.
Medical microbiology and immunology 2003;192(4):211-6.
2003: Achim Hoerauf
Control of filarial infections: not the beginning of the end, but more research is needed.
Current opinion in infectious diseases 2003;16(5):403-10.
2003: Lars Volkmann; Kerstin Fischer; Mark Taylor; Achim Hoerauf
Antibiotic therapy in murine filariasis (Litomosoides sigmodontis): comparative effects of doxycycline and rifampicin on Wolbachia and filarial viability.
Tropical medicine & international health : TM & IH 2003;8(5):392-401.
2003: Achim Hoerauf; Sabine Mand; Lars Volkmann; Marcelle Büttner; Yeboah Marfo-Debrekyei; Mark Taylor; Ohene Adjei; Dietrich W Büttner
Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms.
Microbes and infection / Institut Pasteur 2003;5(4):261-73.
2003: Kenneth Pfarr; Kerstin Fischer; Achim Hoerauf
Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis.
Medical microbiology and immunology 2003;192(1):53-6.
2003: Lars Volkmann; Odile Bain; Michael Saeftel; Sabine Specht; Kerstin Fischer; Frank Brombacher; Klaus I Matthaei; Achim Hoerauf
Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages.
Medical microbiology and immunology 2003;192(1):23-31.
2003: Achim Hoerauf
More research needed to consolidate achievements in filariasis control.
Medical microbiology and immunology 2003;192(1):1-2.
2003: Achim Hoerauf; Dietrich W Büttner; Ohene Adjei; Eric Pearlman
Onchocerciasis.
BMJ (Clinical research ed.) 2003;326(7382):207-10.
2002: Judith Sedaminou Satoguina; Martin Mempel; John Larbi; Marlis Badusche; Cornelius Löliger; Ohene Adjei; Gabriel Gachelin; Bernhard Fleischer; Achim Hoerauf
Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis).
Microbes and infection / Institut Pasteur 2002;4(13):1291-300.
2002: Simone Korten; Lars Volkmann; Michael Saeftel; Kerstin Fischer; Masaru Taniguchi; Bernhard Fleischer; Achim Hoerauf
Expansion of NK cells with reduction of their inhibitory Ly-49A, Ly-49C, and Ly-49G2 receptor-expressing subsets in a murine helminth infection: contribution to parasite control.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5199-206.
2002: Achim Hoerauf; Ohene Adjei; Dietrich W Büttner
Antibiotics for the treatment of onchocerciasis and other filarial infections.
Current opinion in investigational drugs (London, England : 2000) 2002;3(4):533-7.
2002: Amélie v Saint André; Nathan M Blackwell; Laurie R Hall; Achim Hoerauf; Norbert W Brattig; Lars Volkmann; Mark J Taylor; Louise Ford; Amy G Hise; Jonathan H Lass; Eugenia Diaconu; Eric Pearlman
The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness.
Science (New York, N.Y.) 2002;295(5561):1892-5.
2002: Achim Hoerauf; Norbert W Brattig
Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2.
Trends in parasitology 2002;18(1):25-31.
2002: Herbert Schmitz; Bernhard Köhler; Thomas Laue; Christian Drosten; Peter J Veldkamp; Stephan Günther; Petra Emmerich; Hans P Geisen; Klaus Fleischer; Matthias F C Beersma; Achim Hoerauf
Monitoring of clinical and laboratory data in two cases of imported Lassa fever.
Microbes and infection / Institut Pasteur 2002;4(1):43-50.
2002: Achim Hoerauf; Susanne Kruse; Norbert W Brattig; Andrea Heinzmann; Bertram Mueller-Myhsok; Klaus A Deichmann
The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda).
Microbes and infection / Institut Pasteur 2002;4(1):37-42.
2001: Mark J Taylor; Achim Hoerauf
A new approach to the treatment of filariasis.
Current opinion in infectious diseases 2001;14(6):727-31.
2001: Achim Hoerauf; Rolf D Walter; H Remme; J Lazdins; Bernhard Fleischer
Call to consolidate achievements for onchocerciasis and lymphatic filariasis control.
Trends in parasitology 2001;17(12):566-7.
2001: Coralie Martin; Michael Saeftel; P N Vuong; Simon A Babayan; Kerstin Fischer; Odile Bain; Achim Hoerauf
B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection.
Infection and immunity 2001;69(11):7067-73.
2001: Achim Hoerauf; Sabine Mand; Ohene Adjei; Bernhard Fleischer; Dietrich W Büttner
Depletion of wolbachia endobacteria in Onchocerca volvulus by doxycycline and microfilaridermia after ivermectin treatment.
Lancet 2001;357(9266):1415-6.
2001: Norbert W Brattig; Dietrich W Büttner; Achim Hoerauf
Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria.
Microbes and infection / Institut Pasteur 2001;3(6):439-46.
2001: Lars Volkmann; Michael Saeftel; Odile Bain; Kerstin Fischer; Bernhard Fleischer; Achim Hoerauf
Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis.
Infection and immunity 2001;69(5):2950-6.
2001: Michael Saeftel; Bernhard Fleischer; Achim Hoerauf
Stage-dependent role of nitric oxide in control of Trypanosoma cruzi infection.
Infection and immunity 2001;69(4):2252-9.
2001: Michael Saeftel; Lars Volkmann; Simone Korten; Norbert W Brattig; KM Al-Qaoud; Bernhard Fleischer; Achim Hoerauf
Lack of interferon-gamma confers impaired neutrophil granulocyte function and imparts prolonged survival of adult filarial worms in murine filariasis.
Microbes and infection / Institut Pasteur 2001;3(3):203-13.
2001: Achim Hoerauf; Bernhard Fleischer; Rolf D Walter
Of filariasis, mice and men.
Trends in parasitology 2001;17(1):4-5.
2000: Coralie Martin; KM Al-Qaoud; Marie-Noëlle Ungeheuer; K Paehle; Phat N Vuong; Odile Bain; Bernhard Fleischer; Achim Hoerauf
IL-5 is essential for vaccine-induced protection and for resolution of primary infection in murine filariasis.
Medical microbiology and immunology 2000;189(2):67-74.
2000: KM Al-Qaoud; E Pearlman; Thomas Hartung; J Klukowski; Bernhard Fleischer; Achim Hoerauf
A new mechanism for IL-5-dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5.
International immunology 2000;12(6):899-908.
2000: A Doetze; Judith Sedaminou Satoguina; Gerd D Burchard; T Rau; C Löliger; Bernhard Fleischer; Achim Hoerauf
Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift.
International immunology 2000;12(5):623-30.
2000: Achim Hoerauf; Lars Volkmann; Christoph Hamelmann; Ohene Adjei; I B Autenrieth; Bernhard Fleischer; Dietrich W Büttner
Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis.
Lancet 2000;355(9211):1242-3.
2000: Achim Hoerauf; Lars Volkmann; K Nissen-Paehle; Christel Schmetz; I Autenrieth; Dietrich W Büttner; Bernhard Fleischer
Targeting of Wolbachia endobacteria in Litomosoides sigmodontis: comparison of tetracyclines with chloramphenicol, macrolides and ciprofloxacin.
Tropical medicine & international health : TM & IH 2000;5(4):275-9.
2000: Jan ter Meulen; Marlis Badusche; K Kuhnt; A Doetze; Judith Sedaminou Satoguina; Thomas Marti; C Loeliger; Kekoura Koulemou; Lamine Koivogui; Herbert Schmitz; Bernhard Fleischer; Achim Hoerauf
Characterization of human CD4(+) T-cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein.
Journal of virology 2000;74(5):2186-92.
1999: Mark J Taylor; Achim Hoerauf
Wolbachia bacteria of filarial nematodes.
Parasitology today (Personal ed.) 1999;15(11):437-42.
1999: Achim Hoerauf; K Nissen-Pähle; Christel Schmetz; Kimberly Henkle-Dührsen; Mark Blaxter; Dietrich W Büttner; Michaela Gallin; KM Al-Qaoud; Richard Lucius; Bernhard Fleischer
Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility.
The Journal of clinical investigation 1999;103(1):11-8.
1998: KM Al-Qaoud; Bernhard Fleischer; Achim Hoerauf
The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine.
International immunology 1998;10(1):17-25.
1997: KM Al-Qaoud; Anja Taubert; Horst Zahner; Bernhard Fleischer; Achim Hoerauf
Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: role of CD4+ T cells in controlling larval development.
Infection and immunity 1997;65(6):2457-61.
1997: A Doetze; Klaus D Erttmann; Michaela Gallin; Bernhard Fleischer; Achim Hoerauf
Production of both IFN-gamma and IL-5 by Onchocerca volvulus S1 antigen-specific CD4+ T cells from putatively immune individuals.
International immunology 1997;9(5):721-9.