Victor Hoffbrand

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Steele Andrew J; Prentice Archibald G; Hoffbrand A Victor; Yogashangary Birunthini C; Hart Stephen M; Lowdell Mark W; Samuel Edward R; North Janet M; Nacheva Elisabeth P; Chanalaris Anastasios; Kottaridis Panagiotis; Cwynarski Kate; Wickremasinghe R Gitendra
2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.
Hoffbrand A V
Recent advances in the understanding of iron metabolism and iron-related diseases.
Steele Andrew J; Prentice Archibald G; Hoffbrand A Victor; Yogashangary Birunthini C; Hart Stephen M; Nacheva Elisabeth P; Howard-Reeves Julie D; Duke Veronique M; Kottaridis Panagiotis D; Cwynarski Kate; Vassilev Lyubomir T; Wickremasinghe R Gitendra
p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism.

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2009: Steele Andrew J; Prentice Archibald G; Hoffbrand A Victor; Yogashangary Birunthini C; Hart Stephen M; Lowdell Mark W; Samuel Edward R; North Janet M; Nacheva Elisabeth P; Chanalaris Anastasios; Kottaridis Panagiotis; Cwynarski Kate; Wickremasinghe R Gitendra
2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.
Blood 2009;114(6):1217-25.
2009: Hoffbrand A V
Recent advances in the understanding of iron metabolism and iron-related diseases.
Acta haematologica 2009;122(2-3):75-7.
2008: Steele Andrew J; Prentice Archibald G; Hoffbrand A Victor; Yogashangary Birunthini C; Hart Stephen M; Nacheva Elisabeth P; Howard-Reeves Julie D; Duke Veronique M; Kottaridis Panagiotis D; Cwynarski Kate; Vassilev Lyubomir T; Wickremasinghe R Gitendra
p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism.
Blood 2008;112(9):3827-34.
2008: Goulding C; Uttenthal B; Foroni L; Duke V; Traore A; Kottaridis P; Hoffbrand A V; Patch D; McNamara C
The JAK2(V617F) tyrosine kinase mutation identifies clinically latent myeloproliferative disorders in patients presenting with hepatic or portal vein thrombosis.
International journal of laboratory hematology 2008;30(5):415-9.
2008: El-Beshlawy Amal; Manz Chantal; Naja Mohammed; Eltagui Mona; Tarabishi Claudia; Youssry Ilham; Sobh Hewida; Hamdy Mona; Sharaf Iman; Mostafa Azza; Shaker Olfat; Hoffbrand A V; Taher Ali
Iron chelation in thalassemia: combined or monotherapy? The Egyptian experience.
Annals of hematology 2008;87(7):545-50.
2006: Steele A J; Jones D T; Ganeshaguru K; Duke V M; Yogashangary B C; North J M; Lowdell M W; Kottaridis P D; Mehta A B; Prentice A G; Hoffbrand A V; Wickremasinghe R G
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2006;20(6):1073-9.
2006: El-Beshlawy A; Abd El Raouf E; Mostafa F; Talaat M; Isma'eel H; Aoun E; Hoffbrand A V; Taher A
Diastolic dysfunction and pulmonary hypertension in sickle cell anemia: is there a role for L-carnitine treatment?
Acta haematologica 2006;115(1-2):91-6.
2005: Narat Santhosh; Gandla Jagdeesh; Hoffbrand Allan Victor; Hughes Robert George; Mehta Atul B
Rituximab in the treatment of refractory autoimmune cytopenias in adults.
Haematologica 2005;90(9):1273-4.
2005: Hoffbrand A Victor
Oral iron chelators in the treatment of hematologic diseases.
Clinical advances in hematology & oncology : H&O 2005;3(7):536-8.
2005: Hershko Chaim; Hoffbrand A Victor; Keret Dan; Souroujon Moshe; Maschler Itzhak; Monselise Yehudit; Lahad Amnon
Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia.
Haematologica 2005;90(5):585-95.
2005: Swale V J; Saha M; Kapur N; Hoffbrand A V; Rustin M H A
Pyoderma gangrenosum outside the context of inflammatory bowel disease treated successfully with infliximab.
Clinical and experimental dermatology 2005;30(2):134-6.
2005: Taher Ali; Sheikh-Taha Marwan; Sharara Ala; Inati Adlette; Koussa Suzane; Ellis Gareth; Dhillon A P; Hoffbrand A V
Safety and effectiveness of 100 mg/kg/day deferiprone in patients with thalassemia major: a two-year study.
Acta haematologica 2005;114(3):146-9.
2004: Wald Nicholas J; Law Malcolm; Hoffbrand A Victor
Folic acid fortification in the prevention of neural tube defects.
The American journal of clinical nutrition 2004;80(6):1665; author reply 1665-6.
2004: Jones Dylan T; Addison Elena; North Janet M; Lowdell Mark W; Hoffbrand A Victor; Mehta Atul B; Ganeshaguru Kanagasabai; Folarin Najeem I; Wickremasinghe R Gitendra
Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs.
Blood 2004;103(5):1855-61.
2004: Virchis Andres; Koh Mickey; Rankin Peter; Mehta Atul; Potter Michael; Hoffbrand A Victor; Prentice H Grant
Fludarabine, cytosine arabinoside, granulocyte-colony stimulating factor with or without idarubicin in the treatment of high risk acute leukaemia or myelodysplastic syndromes.
British journal of haematology 2004;124(1):26-32.
2004: Taher A; Aoun E; Sharara A I; Mourad F; Gharzuddine W; Koussa S; Inati A; Dhillon A P; Hoffbrand A V
Five-year trial of deferiprone chelation therapy in thalassaemia major patients.
Acta haematologica 2004;112(4):179-83.
2003: Duke Veronique M; Gandini Domenica; Sherrington Paul D; Lin Ke; Heelan Bridget; Amlot Peter; Mehta Atul B; Hoffbrand A Victor; Foroni Letizia
V(H) gene usage differs in germline and mutated B-cell chronic lymphocytic leukemia.
Haematologica 2003;88(11):1259-71.
2003: Hoffbrand A V
Haematology at the Hammersmith Hospital and Royal Postgraduate Medical School 1934-1994.
British journal of haematology 2003;123(2):207-18.
2003: Solomou E E; Sfikakis P P; Kotsi P; Papaioannou M; Karali V; Vervessou E; Hoffbrand A V; Panayiotidis P
13q deletion in chronic lymphocytic leukemia: characterization of E4.5, a novel chromosome condensation regulator-like guanine nucleotide exchange factor.
Leukemia & lymphoma 2003;44(9):1579-85.
2003: Pootrakul Pensri; Sirankapracha Pornpan; Sankote Jongkal; Kachintorn Udom; Maungsub Wanna; Sriphen Kosit; Thakernpol Kleonphan; Atisuk Kanit; Fucharoen Suthat; Chantraluksri Udom; Shalev Oded; Hoffbrand A Victor
Clinical trial of deferiprone iron chelation therapy in beta-thalassaemia/haemoglobin E patients in Thailand.
British journal of haematology 2003;122(2):305-10.
2003: Hoffbrand A Victor; Cohen Alan; Hershko Chaim
Role of deferiprone in chelation therapy for transfusional iron overload.
Blood 2003;102(1):17-24.
2003: Mourad Fadi H; Hoffbrand A Victor; Sheikh-Taha Marwan; Koussa Susane; Khoriaty Adlette I; Taher Ali
Comparison between desferrioxamine and combined therapy with desferrioxamine and deferiprone in iron overloaded thalassaemia patients.
British journal of haematology 2003;121(1):187-9.
2003: Jones Dylan T; Ganeshaguru Kanagasabai; Anderson Robert J; Jackson Trevor R; Bruckdorfer K Richard; Low Sylvia Y; Palmqvist Lars; Prentice H Grant; Hoffbrand A Victor; Mehta Atul B; Wickremasinghe R Gitendra
Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis.
Blood 2003;101(8):3174-80.
2003: Beutler Ernest; Hoffbrand A Victor; Cook James D
Iron deficiency and overload.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2003;():40-61.
2002: Gameiro Paula; Moreira Ilídia; Yetgin Sevgi; Papaioannou Mary; Potter Michael N; Prentice H Grant; Hoffbrand A Victor; Foroni Letizia
Polymerase chain reaction (PCR)- and reverse transcription PCR-based minimal residual disease detection in long-term follow-up of childhood acute lymphoblastic leukaemia.
British journal of haematology 2002;119(3):685-96.
2002: Gameiro Paula; Mortuza Forida Y; Hoffbrand A Victor; Foroni Letizia
Minimal residual disease monitoring in adult T-cell acute lymphoblastic leukemia: a molecular based approach using T-cell receptor G and D gene rearrangements.
Haematologica 2002;87(11):1126-34.
2002: Rowntree C; Duke V; Panayiotidis P; Kotsi P; Palmisano G L; Hoffbrand A V; Foroni L
Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(7):1267-75.
2002: Howard Jo; Hoffbrand A Victor; Prentice H Grant; Mehta Atul
Mycophenolate mofetil for the treatment of refractory auto-immune haemolytic anaemia and auto-immune thrombocytopenia purpura.
British journal of haematology 2002;117(3):712-5.
2002: Foroni Letizia; Hoffbrand A Victor
Molecular analysis of minimal residual disease in adult acute lymphoblastic leukaemia.
Best practice & research. Clinical haematology 2002;15(1):71-90.
2002: Mortuza Forida Y; Papaioannou Mary; Moreira Ilidia M; Coyle Luke A; Gameiro Paula; Gandini Domenica; Prentice H Grant; Goldstone Anthony; Hoffbrand A Victor; Foroni Letizia
Minimal residual disease tests provide an independent predictor of clinical outcome in adult acute lymphoblastic leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(4):1094-104.
2002: Ganeshaguru Kanagasabai; Wickremasinghe Ranmohan G; Jones Dylan T; Gordon Mathew; Hart Steve M; Virchis Andres E; Prentice H Grant; Hoffbrand A Victor; Man Anthony; Champain Kate; Csermak Katalin; Mehta Atul B
Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro.
Haematologica 2002;87(2):167-76.
2001: Jones D T; Ganeshaguru K; Virchis A E; Folarin N I; Lowdell M W; Mehta A B; Prentice H G; Hoffbrand A V; Wickremasinghe R G
Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation.
Blood 2001;98(9):2800-7.
2001: Moreira I; Papaioannou M; Mortuza F Y; Gameiro P; Palmisano G L; Harrison C J; Prentice H G; Mehta A B; Hoffbrand A V; Foroni L
Heterogeneity of VH-JH gene rearrangement patterns: an insight into the biology of B cell precursor ALL.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(10):1527-36.
2001: Wickremasinghe R G; Ganeshaguru K; Jones D T; Lindsay C; Spanswick V J; Hartley J A; Wadhwa M; Thorpe R; Hoffbrand A V; Prentice H G; Mehta A B
Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells.
British journal of haematology 2001;114(3):608-15.
2001: Shaw B E; Perry D; Hoffbrand A V
Progressive arterial thrombosis in a patient with non-Hodgkin's lymphoma, a lupus anticoagulant, factor V Leiden mutation and paraprotein, following chemotherapy.
Leukemia & lymphoma 2001;42(1-2):221-3.
2001: Gameiro P; Vieira S; Carrara P; Silva A L; Diamond J; Botelho de Sousa A; Mehta A B; Prentice H G; Guimarães J E; Hoffbrand A V; Foroni L; Parreira A
The PML-RAR alpha transcript in long-term follow-up of acute promyelocytic leukemia patients.
Haematologica 2001;86(6):577-85.
2001: Mortuza F Y; Moreira I M; Papaioannou M; Gameiro P; Coyle L A; Gricks C S; Amlot P; Prentice H G; Madrigal A; Hoffbrand A V; Foroni L
Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of J(H)-proximal variable gene segments.
Blood 2001;97(9):2716-26.
2000: Codrington R; O'Connor H E; Jalali G R; Carrara P; Papaioannou M; Hart S M; Hoffbrand A V; Potter M; Prentice H G; Harrison C J; Foroni L
Analysis of ETV6/AML1 abnormalities in acute lymphoblastic leukaemia: incidence, alternative spliced forms and minimal residual disease value.
British journal of haematology 2000;111(4):1071-9.
2000: Telfer P T; Prestcott E; Holden S; Walker M; Hoffbrand A V; Wonke B
Hepatic iron concentration combined with long-term monitoring of serum ferritin to predict complications of iron overload in thalassaemia major.
British journal of haematology 2000;110(4):971-7.
1999: Hoffbrand A V; Fantini B
Achievements in hematology in the twentieth century: an introduction.
Seminars in hematology 1999;36(4 Suppl 7):1-4.
1999: Wickremasinghe R G; Hoffbrand A V
Biochemical and genetic control of apoptosis: relevance to normal hematopoiesis and hematological malignancies.
Blood 1999;93(11):3587-600.
1999: Mengubas K; Fahey A A; Lewin J; Mehta A B; Hoffbrand A V; Wickremasinghe R G
Killing of T lymphocytes by synthetic ceramide is by a nonapoptotic mechanism and is abrogated following mitogenic activation.
Experimental cell research 1999;249(1):116-22.
1999: Foroni L; Harrison C J; Hoffbrand A V; Potter M N
Investigation of minimal residual disease in childhood and adult acute lymphoblastic leukaemia by molecular analysis.
British journal of haematology 1999;105(1):7-24.
1999: Mengubas K; Riordan F A; Bravery C A; Lewin J; Owens D L; Mehta A B; Hoffbrand A V; Wickremasinghe R G
Ceramide-induced killing of normal and malignant human lymphocytes is by a non-apoptotic mechanism.
Oncogene 1999;18(15):2499-506.
1998: Deane M; Koh M; Foroni L; Galactowicz G; Hoffbrand A V; Lawler M; Secker-Walker L; Prentice H G
FLAG-idarubicin and allogeneic stem cell transplantation for Ph-positive ALL beyond first remission.
Bone marrow transplantation 1998;22(12):1137-43.
1998: Jensen C E; Tuck S M; Agnew J E; Koneru S; Morris R W; Yardumian A; Prescott E; Hoffbrand A V; Wonke B
High prevalence of low bone mass in thalassaemia major.
British journal of haematology 1998;103(4):911-5.
1998: Wonke B; Telfer P; Hoffbrand A V
Iron chelation with oral deferiprone in patients with thalassemia.
The New England journal of medicine 1998;339(23):1712; author reply 1713-4.
1998: Wonke B; Wright C; Hoffbrand A V
Combined therapy with deferiprone and desferrioxamine.
British journal of haematology 1998;103(2):361-4.
1998: Riordan F A; Foroni L; Hoffbrand A V; Mehta A B; Wickremasinghe R G
Okadaic acid-induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl-2 mRNA and downregulation of bcl-2 protein.
FEBS letters 1998;435(2-3):195-8.
1998: Wonke B; Hoffbrand A V; Bouloux P; Jensen C; Telfer P
New approaches to the management of hepatitis and endocrine disorders in Cooley's anemia.
Annals of the New York Academy of Sciences 1998;850():232-41.
1998: Riordan F A; Bravery C A; Mengubas K; Ray N; Borthwick N J; Akbar A N; Hart S M; Hoffbrand A V; Mehta A B; Wickremasinghe R G
Herbimycin A accelerates the induction of apoptosis following etoposide treatment or gamma-irradiation of bcr/abl-positive leukaemia cells.
Oncogene 1998;16(12):1533-42.
1998: Foroni L; Panayiotidis P; Hoffbrand A V
Lack of clonal BCRA2 gene deletion on chromosome 13 in chronic lymphocytic leukaemia: an update of recent scientific reports.
British journal of haematology 1998;100(4):800.
1998: Hoffbrand A V; AL-Refaie F; Davis B; Siritanakatkul N; Jackson B F; Cochrane J; Prescott E; Wonke B
Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients.
Blood 1998;91(1):295-300.
1998: Jensen C E; Tuck S M; Agnew J E; Koneru S; Morris R W; Yardumian A; Prescott E; Hoffbrand A V; Wonke B
High incidence of osteoporosis in thalassaemia major.
Journal of pediatric endocrinology & metabolism : JPEM 1998;11 Suppl 3():975-7.
1998: Wonke B; Jensen C; Hanslip J J; Prescott E; Lalloz M; Layton M; Erten S; Tuck S; Agnew J E; Raja K; Davies K; Hoffbrand A V
Genetic and acquired predisposing factors and treatment of osteoporosis in thalassaemia major.
Journal of pediatric endocrinology & metabolism : JPEM 1998;11 Suppl 3():795-801.
1997: Hart S M; Ganeshaguru K; Scheper R J; Prentice H G; Hoffbrand A V; Mehta A B
Expression of the human major vault protein LRP in acute myeloid leukemia.
Experimental hematology 1997;25(12):1227-32.
1997: Foroni L; Coyle L A; Papaioannou M; Yaxley J C; Sinclair M F; Chim J S; Cannell P; Secker-Walker L M; Mehta A B; Prentice H G; Hoffbrand A V
Molecular detection of minimal residual disease in adult and childhood acute lymphoblastic leukaemia reveals differences in treatment response.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11(10):1732-41.
1997: Telfer P T; Garson J A; Whitby K; Grant P R; Yardumian A; Hoffbrand A V; Wonke B
Combination therapy with interferon alpha and ribavirin for chronic hepatitis C virus infection in thalassaemic patients.
British journal of haematology 1997;98(4):850-5.
1997: Jensen C E; Tuck S M; Old J; Morris R W; Yardumian A; De Sanctis V; Hoffbrand A V; Wonke B
Incidence of endocrine complications and clinical disease severity related to genotype analysis and iron overload in patients with beta-thalassaemia.
European journal of haematology 1997;59(2):76-81.
1997: Basu S; Panayiotidis P; Hart S M; He L Z; Man A; Hoffbrand A V; Ganeshaguru K
Role of double-stranded RNA-activated protein kinase in human hematological malignancies.
Cancer research 1997;57(5):943-7.
1997: Panayiotidis P; Ganeshaguru K; Hoffbrand A V; Rowntree C; Jabbar S A; Foroni L
Deletion of 13q14.3 and not 13q12 is the most common genetic abnormality detected in chronic lymphocytic leukemia cells.
Blood 1997;89(2):734-5.
1997: Hoffbrand A V; Wonke B
Iron chelation therapy.
Journal of internal medicine. Supplement 1997;740():37-41.
1996: Noble K E; Panayiotidis P; Collins P W; Hoffbrand A V; Yong K L
Monocytes induce E-selectin gene expression in endothelial cells: role of CD11/CD18 and extracellular matrix proteins.
European journal of immunology 1996;26(12):2944-51.
1996: Mengubas K; Riordan F A; Hoffbrand A V; Wickremasinghe R G
Co-ordinated downregulation of bcl-2 and bax expression during granulocytic and macrophage-like differentiation of the HL60 promyelocytic leukaemia cell line.
FEBS letters 1996;394(3):356-60.
1996: Coyle L A; Papaioannou M; Yaxley J C; Chim J S; Attard M; Hoffbrand A V; Foroni L
Molecular analysis of the leukaemic B cell in adult and childhood acute lymphoblastic leukaemia.
British journal of haematology 1996;94(4):685-93.
1996: Reittie J E; Yong K L; Panayiotidis P; Hoffbrand A V
Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia.
Leukemia & lymphoma 1996;22(1-2):83-90, follow. 186, color plate VI.
1996: Araujo A; Kosaryan M; MacDowell A; Wickens D; Puri S; Wonke B; Hoffbrand A V
A novel delivery system for continuous desferrioxamine infusion in transfusional iron overload.
British journal of haematology 1996;93(4):835-7.
1996: Yeghen T; Fenelon L; Campbell C K; Warnock D W; Hoffbrand A V; Prentice H G; Kibbler C C
Chaetomium pneumonia in patient with acute myeloid leukaemia.
Journal of clinical pathology 1996;49(2):184-6.
1996: Tay D L; Hoffbrand A V; Wickremasinghe G R
Expression of c-fos and c-jun proteins and AP-1 binding activity during cell cycle progression of HL60 cells and phytohemagglutinin-stimulated lymphocytes.
Experimental hematology 1996;24(2):277-84.
1996: Hoffbrand A V
Oral iron chelation.
Seminars in hematology 1996;33(1):1-8.
1996: Panayiotidis P; Jones D; Ganeshaguru K; Foroni L; Hoffbrand A V
Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro.
British journal of haematology 1996;92(1):97-103.
1995: Collins P W; Noble K E; Reittie J R; Hoffbrand A V; Pasi K J; Yong K L
Induction of tissue factor expression in human monocyte/endothelium cocultures.
British journal of haematology 1995;91(4):963-70.
1995: al-Refaie F N; Hershko C; Hoffbrand A V; Kosaryan M; Olivieri N F; Tondury P; Wonke B
Results of long-term deferiprone (L1) therapy: a report by the International Study Group on Oral Iron Chelators.
British journal of haematology 1995;91(1):224-9.
1995: Panayiotidis P; Ganeshaguru K; Foroni L; Hoffbrand A V
Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(7):1227-32.
1995: Jabbar S A; Hoffbrand A V; Wickremasinghe R G
Defects in signal transduction pathways in chronic B lymphocytic leukemia cells.
Leukemia & lymphoma 1995;18(1-2):163-70.
1995: Jabbar S A; Ganeshaguru K; Wickremasinghe R G; Hoffbrand A V; Foroni L
Deletion of chromosome 13 (band q14) but not trisomy 12 is a clonal event in B-chronic lymphocytic leukaemia (CLL).
British journal of haematology 1995;90(2):476-8.
1995: Devaraj P E; Foroni L; Janossy G; Hoffbrand A V; Secker-Walker L M
Expression of the E2A-PBX1 fusion transcripts in t(1;19)(q23;p13) and der(19)t(1;19) at diagnosis and in remission of acute lymphoblastic leukemia with different B lineage immunophenotypes.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(5):821-5.
1995: Hoffbrand A V
Iron chelation therapy.
Current opinion in hematology 1995;2(2):153-8.
1995: al-Refaie F N; Sheppard L N; Nortey P; Wonke B; Hoffbrand A V
Pharmacokinetics of the oral iron chelator deferiprone (L1) in patients with iron overload.
British journal of haematology 1995;89(2):403-8.
1995: al-Refaie F N; De Silva C E; Wonke B; Hoffbrand A V
Changes in transferrin saturation after treatment with the oral iron chelator deferiprone in patients with iron overload.
Journal of clinical pathology 1995;48(2):110-4.
1995: Hileti D; Panayiotidis P; Hoffbrand A V
Iron chelators induce apoptosis in proliferating cells.
British journal of haematology 1995;89(1):181-7.
1994: al-Refaie F N; Hoffbrand A V
Oral iron-chelating therapy: the L1 experience.
Baillière's clinical haematology 1994;7(4):941-63.
1994: Hart S M; Ganeshaguru K; Hoffbrand A V; Prentice H G; Mehta A B
Expression of the multidrug resistance-associated protein (MRP) in acute leukaemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(12):2163-8.
1994: al-Refaie F N; Wonke B; Hoffbrand A V
Deferiprone-associated myelotoxicity.
European journal of haematology 1994;53(5):298-301.
1994: Hawkins J M; Moorman A V; Hoffbrand A V; Martineau M; Wright F S; Mehta A B; Prentice H G; Secker-Walker L M
Association of 17p loss with late-stage or refractory disease in hematologic malignancy.
Cancer genetics and cytogenetics 1994;77(2):134-43.
1994: Mengubas K; Jabbar S A; Nye K E; Wilkes S; Hoffbrand A V; Wickremasinghe R G
Inactivation of calcium ion-regulating inositol polyphosphate second messengers is impaired in subpopulations of human leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(10):1718-25.
1994: al-Refaie F N; Wonke B; Wickens D G; Aydinok Y; Fielding A; Hoffbrand A V
Zinc concentration in patients with iron overload receiving oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one or desferrioxamine.
Journal of clinical pathology 1994;47(7):657-60.
1994: Cannell P K; Amlot P; Attard M; Hoffbrand A V; Foroni L
Variable kappa gene rearrangement in lymphoproliferative disorders: an analysis of V kappa gene usage, VJ joining and somatic mutation.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(7):1139-45.
1994: Jabbar S A; Hoffbrand A V; Wickremasinghe R G
Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kappa B following tumour necrosis factor treatment of chronic B-leukaemia cells.
Leukemia research 1994;18(7):523-30.
1994: al-Refaie F N; Wonke B; Hoffbrand A V
Arthropathy in thalassaemia patients receiving deferiprone.
Lancet 1994;344(8917):262-3.
1994: Devaraj P E; Foroni L; Sekhar M; Butler T; Wright F; Mehta A; Samson D; Prentice H G; Hoffbrand A V; Secker-Walker L M
E2A/HLF fusion cDNAs and the use of RT-PCR for the detection of minimal residual disease in t(17;19)(q22;p13) acute lymphoblastic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1994;8(7):1131-8.
1994: Cole-Sinclair M F; Foroni L; Hoffbrand A V
Genetic changes: relevance for diagnosis and detection of minimal residual disease in acute lymphoblastic leukaemia.
Baillière's clinical haematology 1994;7(2):183-233.
1994: al-Rafaie F N; Wilkes S; Wonke B; Hoffbrand A V
The effect of deferiprone (L1) and desferrioxamine on myelopoiesis using a liquid culture system.
British journal of haematology 1994;87(1):196-8.
1994: Hoffbrand A V
Prospects for oral iron chelation therapy.
The Journal of laboratory and clinical medicine 1994;123(4):492-4.
1994: Dixon R M; Styles P; al-Refaie F N; Kemp G J; Donohue S M; Wonke B; Hoffbrand A V; Radda G K; Rajagopalan B
Assessment of hepatic iron overload in thalassemic patients by magnetic resonance spectroscopy.
Hepatology (Baltimore, Md.) 1994;19(4):904-10.
1994: Cunningham J M; al-Refaie F N; Hunter A E; Sheppard L N; Hoffbrand A V
Differential toxicity of alpha-keto hydroxypyridine iron chelators and desferrioxamine to human haemopoietic precursors in vitro.
European journal of haematology 1994;52(3):176-9.
1994: Jabbar S A; Hoffbrand A V; Gitendra Wickremasinghe R
Regulation of transcription factors NF kappa B and AP-1 following tumour necrosis factor-alpha treatment of cells from chronic B cell leukaemia patients.
British journal of haematology 1994;86(3):496-504.
1994: Lyttelton M P; Hart S; Ganeshaguru K; Hoffbrand A V; Mehta A B
Quantitation of multidrug resistant MDR1 transcript in acute myeloid leukaemia by non-isotopic quantitative cDNA-polymerase chain reaction.
British journal of haematology 1994;86(3):540-6.
1994: Reittie J E; Hoffbrand A V
Interleukin-4 (IL-4) inhibits proliferation and spontaneous cytokine release by chronic lymphocytic leukaemia cells.
Leukemia research 1994;18(1):55-60.
1994: Panayiotidis P; Ganeshaguru K; Jabbar S A; Hoffbrand A V
Alpha-interferon (alpha-IFN) protects B-chronic lymphocytic leukaemia cells from apoptotic cell death in vitro.
British journal of haematology 1994;86(1):169-73.
1993: Panayiotidis P; Ganeshaguru K; Jabbar S A; Hoffbrand A V
Interleukin-4 inhibits apoptotic cell death and loss of the bcl-2 protein in B-chronic lymphocytic leukaemia cells in vitro.
British journal of haematology 1993;85(3):439-45.
1993: Hart S M; Ganeshaguru K; Lyttelton M P; Prentice H G; Hoffbrand A V; Mehta A B
Flow cytometric assessment of multidrug resistance (MDR) phenotype in acute myeloid leukaemia.
Leukemia & lymphoma 1993;11(3-4):239-48.
1993: Hoffbrand A V; Panayiotidis P; Reittie J; Ganeshaguru K
Autocrine and paracrine growth loops in chronic lymphocytic leukemia.
Seminars in hematology 1993;30(4):306-17.
1993: Wickremasinghe R G; Porfiri E; Hoffbrand A V
Evidence that inositol phospholipids, but not choline phospholipids, are a potential source of growth-regulating second messenger molecules in HL60 leukaemia cells.
Leukemia research 1993;17(9):763-9.
1993: Khan M A; Hoffbrand A V; Mehta A; Wright F; Tahami F; Wickremasinghe R G
MK 886, an antagonist of leukotriene generation, inhibits DNA synthesis in a subset of acute myeloid leukaemia cells.
Leukemia research 1993;17(9):759-62.
1993: McWhinney P H; Kibbler C C; Hamon M D; Smith O P; Gandhi L; Berger L A; Walesby R K; Hoffbrand A V; Prentice H G
Progress in the diagnosis and management of aspergillosis in bone marrow transplantation: 13 years' experience.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1993;17(3):397-404.
1993: Khan M A; Jeremy J Y; Hallinan T; Tateson J E; Hoffbrand A V; Wickremasinghe R G
Antioxidants impair the coupling of cell-surface ligand receptors to the inositol lipid signalling pathway in human T lymphocytes but not in Jurkat T lymphoblastic leukemia cells. Evidence that leukotrienes are not involved in the coupling mechanism.
Biochimica et biophysica acta 1993;1178(2):215-20.
1993: Porfiri E; Secker-Walker L M; Hoffbrand A V; Hancock J F
DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18.
Blood 1993;81(10):2696-701.
1993: Sissolak G; Hoffbrand A V; Mehta A B; Ganeshaguru K
Interferon-alpha inducible 2'-5' oligoadenylate synthetase transcripts in lymphoid and myeloid leukemias.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1993;7(5):712-6.
1993: Hoffbrand A V; Jackson B F
Correction of the DNA synthesis defect in vitamin B12 deficiency by tetrahydrofolate: evidence in favour of the methyl-folate trap hypothesis as the cause of megaloblastic anaemia in vitamin B12 deficiency.
British journal of haematology 1993;83(4):643-7.
1993: Ayyub Khan M; Tateson J E; Hoffbrand A V; Wickremasinghe R G
Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant hemopoietic cell lines.
Leukemia research 1993;17(3):241-5.
1993: Donohue S M; Wonke B; Hoffbrand A V; Reittie J; Ganeshaguru K; Scheuer P J; Brown D; Dusheiko G
Alpha interferon in the treatment of chronic hepatitis C infection in thalassaemia major.
British journal of haematology 1993;83(3):491-7.
1993: Wickremasinghe R G; Khan M A; Hoffbrand A V
Do leukotrienes play a role in the regulation of proliferation of normal and leukemic hemopoietic cells?
Prostaglandins, leukotrienes, and essential fatty acids 1993;48(2):123-6.
1993: al-Refaie F N; Veys P A; Wilkes S; Wonke B; Hoffbrand A V
Agranulocytosis in a patient with thalassaemia major during treatment with the oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one.
Acta haematologica 1993;89(2):86-90.
1993: Wonke B; Donohue S M; Hoffbrand A V; Scheuer P J; Brown D; Dusheiko G
Recombinant alpha 2B interferon (IFN) in the treatment of chronic hepatitis C disease in thalassaemia major (TM).
Bone marrow transplantation 1993;12 Suppl 1():24-5.
1993: Cole-Sinclair M; Foroni L; Wright F; Mehta A; Prentice H G; Hoffbrand A V
Minimal residual disease in acute lymphoblastic leukaemia--PCR analysis of immunoglobulin gene rearrangements.
Leukemia & lymphoma 1993;11 Suppl 2():49-58.
1993: Deane M; Hoffbrand A V
Detection of minimal residual disease in ALL.
Cancer treatment and research 1993;64():135-70.
1992: Sissolak G; Hoffbrand A V; Mehta A B; Ganeshaguru K
Effects of interferon-alpha (IFN) on the expression of interleukin 1-beta (IL-1), interleukin 6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF) and tumor necrosis factor-alpha (TNF) in acute myeloid leukemia (AML) blasts.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1992;6(11):1155-60.
1992: al-Refaie F N; Wickens D G; Wonke B; Kontoghiorghes G J; Hoffbrand A V
Serum non-transferrin-bound iron in beta-thalassaemia major patients treated with desferrioxamine and L1.
British journal of haematology 1992;82(2):431-6.
1992: al-Refaie F N; Wonke B; Hoffbrand A V; Wickens D G; Nortey P; Kontoghiorghes G J
Efficacy and possible adverse effects of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in thalassemia major.
Blood 1992;80(3):593-9.
1992: Huang D; Reittie J E; Stephens S; Hoffbrand A V; Brenner M K
Effects of anti-TNF monoclonal antibody infusion in patients with hairy cell leukaemia.
British journal of haematology 1992;81(2):231-4.
1992: Duncombe A S; Grundy J E; Oblakowski P; Prentice H G; Gottlieb D J; Roy D M; Reittie J E; Bello-Fernandez C; Hoffbrand A V; Brenner M K
Bone marrow transplant recipients have defective MHC-unrestricted cytotoxic responses against cytomegalovirus in comparison with Epstein-Barr virus: the importance of target cell expression of lymphocyte function-associated antigen 1 (LFA1).
Blood 1992;79(11):3059-66.
1992: McWhinney P H; Kibbler C C; Gillespie S H; Patel S; Morrison D; Hoffbrand A V; Prentice H G
Stomatococcus mucilaginosus: an emerging pathogen in neutropenic patients.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1992;14(3):641-6.
1992: Ganeshaguru K; de Mel W C; Sissolak G; Catovsky D; Dearden C E; Mehta A B; Hoffbrand A V
Increase in 2',5'-oligoadenylate synthetase caused by deoxycoformycin in hairy cell leukaemia.
British journal of haematology 1992;80(2):194-8.
1992: McWhinney P H; Madgwick J C; Hoffbrand A V; Bhamra A; Kibbler C C
Successful surgical management of septic arthritis due to Trichosporon beigelii in a patient with acute myeloid leukaemia.
Scandinavian journal of infectious diseases 1992;24(2):245-7.
1992: Veys P A; Wilkes S; Shah S; Noyelle R; Hoffbrand A V
Clinical experience of clozapine-induced neutropenia in the UK. Laboratory investigation using liquid culture systems and immunofluorocytometry.
Drug safety : an international journal of medical toxicology and drug experience 1992;7 Suppl 1():26-32.
1991: Veys P A; Wilkes S; Hoffbrand A V
Deficiency of neutrophil FcR III.
Blood 1991;78(3):852-3.
1991: Porfiri E; Hoffbrand A V; Wickremasinghe R G
Retinoic acid-induced granulocytic differentiation of HL60 human promyelocytic leukemia cells is preceded by downregulation of autonomous generation of inositol lipid-derived second messengers.
Blood 1991;78(4):1069-77.
1991: Gilmore M J; Hamon M D; Prentice H G; Katz F; Slaper-Cortenbach I C; Hunter A E; Gandhi L; Brenner M K; Hoffbrand A V; Mehta A B
Failure of purged autologous bone marrow transplantation in high risk acute lymphoblastic leukaemia in first complete remission.
Bone marrow transplantation 1991;8(1):19-26.
1991: Oblakowski P; Bello-Fernandez C; Reittie J E; Heslop H E; Galatowicz G; Veys P; Wilkes S; Prentice H G; Hazlehurst G; Hoffbrand A V
Possible mechanism of selective killing of myeloid leukemic blast cells by lymphokine-activated killer cells.
Blood 1991;77(9):1996-2001.
1991: Secker-Walker L M; Craig J M; Hawkins J M; Hoffbrand A V
Philadelphia positive acute lymphoblastic leukemia in adults: age distribution, BCR breakpoint and prognostic significance.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1991;5(3):196-9.
1991: Heslop H E; Duncombe A S; Reittie J E; Bello-Fernandez C; Gottlieb D J; Prentice H G; Mehta A B; Hoffbrand A V; Brenner M K
Interleukin 2 infusion induces haemopoietic growth factors and modifies marrow regeneration after chemotherapy or autologous marrow transplantation.
British journal of haematology 1991;77(2):237-44.
1991: Heslop H E; Duncombe A S; Reittie J E; Bello-Fernandez C; Gottlieb D J; Prentice H G; Hoffbrand A V; Brenner M K
Interleukin-2 infusion after autologous bone marrow transplantation enhances hemopoietic regeneration.
Transplantation proceedings 1991;23(1 Pt 2):1704-5.
1991: Bello-Fernandez C; Oblakowski P; Meager A; Duncombe A S; Rill D M; Hoffbrand A V; Brenner M K
IL-4 acts as a homeostatic regulator of IL-2-induced TNF and IFN-gamma.
Immunology 1991;72(2):161-6.
1991: McWhinney P H; Gillespie S H; Kibbler C C; Hoffbrand A V; Prentice H G
Streptococcus mitis and ARDS in neutropenic patients.
Lancet 1991;337(8738):429.
1991: Smith O P; Prentice H G; Hazlehurst G; Brozovic B; Hoffbrand A V; Mehta A B
Blood product support in patients undergoing chemotherapy and autologous or allogeneic bone marrow transplantation for haematological malignancies.
Clinical and laboratory haematology 1991;13(2):107-14.
1991: Ganeshaguru K; de Mel W C; Sissolak G; Catovsky D; Dearden C E; Mehta A B; Hoffbrand A V
Increase in 2',5'-oligoadenylate synthetase caused by deoxycoformycin in hairy cell leukaemia.
Advances in experimental medicine and biology 1991;309A():65-8.
1990: Heslop H E; Bianchi A C; Cordingley F T; Turner M; Chandima W; De Mel C P; Hoffbrand A V; Brenner M K
Effects of interferon alpha on autocrine growth factor loops in B lymphoproliferative disorders.
The Journal of experimental medicine 1990;172(6):1729-34.
1990: Bartlett A N; Hoffbrand A V; Kontoghiorghes G J
Long-term trial with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). II. Clinical observations.
British journal of haematology 1990;76(2):301-4.
1990: Kontoghiorghes G J; Bartlett A N; Hoffbrand A V; Goddard J G; Sheppard L; Barr J; Nortey P
Long-term trial with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1). I. Iron chelation and metabolic studies.
British journal of haematology 1990;76(2):295-300.
1990: Duncombe A S; Meager A; Prentice H G; Grundy J E; Heslop H E; Hoffbrand A V; Brenner M K
Gamma-interferon and tumor necrosis factor production after bone marrow transplantation is augmented by exposure to marrow fibroblasts infected with cytomegalovirus.
Blood 1990;76(5):1046-53.
1990: Gottlieb D J; Prentice H G; Mehta A B; Galazka A R; Heslop H E; Hoffbrand A V; Brenner M K
Malignant plasma cells are sensitive to LAK cell lysis: pre-clinical and clinical studies of interleukin 2 in the treatment of multiple myeloma.
British journal of haematology 1990;75(4):499-505.
1990: Wonke B; Hoffbrand A V; Brown D; Dusheiko G
Antibody to hepatitis C virus in multiply transfused patients with thalassaemia major.
Journal of clinical pathology 1990;43(8):638-40.
1990: Hall B S; Hoffbrand A V; Wickremasinghe R G
Multiple tyrosine protein kinases structurally related to p56 lck are down-regulated following mitogenic stimulation of human T lymphocytes.
Biochemical and biophysical research communications 1990;170(1):127-33.
1990: Gignac S M; Buschie M; Pettit G R; Hoffbrand A V; Drexler H G
Expression of proto-oncogene c-jun during differentiation of B-chronic lymphocytic leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1990;4(6):441-4.
1990: Gignac S M; Buschle M; Hoffbrand A V; Drexler H G
Down-regulation of CD5 mRNA in B-chronic lymphocytic leukemia cells by differentiation-inducing agents.
European journal of immunology 1990;20(5):1119-23.
1990: Aldouri M A; Lopes M E; Yacoub M; Mitchell A G; Fox K; Evans T R; Hoffbrand A V
Cardiac transplantation for doxorubicin-induced cardiomyopathy in acute myeloid leukaemia.
British journal of haematology 1990;74(4):541.
1990: de Mel W C; Hoffbrand A V; Giles F J; Goldstone A H; Mehta A B; Ganeshaguru K
Alpha interferon therapy for haematological malignancies: correlation between in vivo induction of the 2',5'oligoadenylate system and clinical response.
British journal of haematology 1990;74(4):452-6.
1990: Drexler H G; Gignac S M; Pettit G R; Hoffbrand A V
Synergistic action of calcium ionophore A23187 and protein kinase C activator bryostatin 1 on human B cell activation and proliferation.
European journal of immunology 1990;20(1):119-27.
1990: Evans J P; Mire-Sluis A R; Hoffbrand A V; Wickremasinghe R G
Binding of G-CSF, GM-CSF, tumor necrosis factor-alpha, and gamma-interferon to cell surface receptors on human myeloid leukemia cells triggers rapid tyrosine and serine phosphorylation of a 75-Kd protein.
Blood 1990;75(1):88-95.
1990: Aldouri M A; Wonke B; Hoffbrand A V; Flynn D M; Ward S E; Agnew J E; Hilson A J
High incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation.
Acta haematologica 1990;84(3):113-7.
1989: Mire-Sluis A R; Cox C A; Hoffbrand A V; Wickremasinghe R G
Inhibitors of arachidonic acid lipoxygenase impair the stimulation of inositol phospholipid hydrolysis by the T lymphocyte mitogen phytohaemagglutinin.
FEBS letters 1989;258(1):84-8.
1989: Gottlieb D J; Brenner M K; Heslop H E; Bianchi A C; Bello-Fernandez C; Mehta A B; Newland A C; Galazka A R; Scott E M; Hoffbrand A V
A phase I clinical trial of recombinant interleukin 2 following high dose chemo-radiotherapy for haematological malignancy: applicability to the elimination of minimal residual disease.
British journal of cancer 1989;60(4):610-5.
1989: Hall B S; Hoffbrand A V; Wickremasinghe R G
An endogenous inhibitor of the protein tyrosine kinase activity of normal and malignant human lymphoid cells.
Oncogene 1989;4(10):1225-31.
1989: Drexler H G; Gignac S M; Jones R A; Scott C S; Pettit G R; Hoffbrand A V
Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells.
Blood 1989;74(5):1747-57.
1989: Heslop H E; Gottlieb D J; Bianchi A C; Meager A; Prentice H G; Mehta A B; Hoffbrand A V; Brenner M K
In vivo induction of gamma interferon and tumor necrosis factor by interleukin-2 infusion following intensive chemotherapy or autologous marrow transplantation.
Blood 1989;74(4):1374-80.
1989: Drexler H G; Gignac S M; Hoffbrand A V; Minowada J
Formation of multinucleated cells in a Hodgkin's-disease-derived cell line.
International journal of cancer. Journal international du cancer 1989;43(6):1083-90.
1989: Chiu E K; Ganeshaguru K; Hoffbrand A V; Mehta A B
Circulating monoclonal B lymphocytes in multiple myeloma.
British journal of haematology 1989;72(1):28-31.
1989: Porfiri E; Hoffbrand A V; Wickremasinghe R G
Induction of macrophage-like differentiation of HL60 human myeloid leukemia cells by phorbol myristate acetate triggers an early decline in inositol lipid breakdown.
Experimental hematology 1989;17(4):344-50.
1989: Kibbler C C; Prentice H G; Sage R J; Hoffbrand A V; Brenner M K; Mannan P; Warner P; Bhamra A; Noone P
A comparison of double beta-lactam combinations with netilmicin/ureidopenicillin regimens in the empirical therapy of febrile neutropenic patients.
The Journal of antimicrobial chemotherapy 1989;23(5):759-71.
1989: Drexler H G; Janssen J W; Brenner M K; Hoffbrand A V; Bartram C R
Rapid expression of protooncogenes c-fos and c-myc in B-chronic lymphocytic leukemia cells during differentiation induced by phorbol ester and calcium ionophore.
Blood 1989;73(6):1656-63.
1989: Kibbler C C; Prentice H G; Sage R J; Hoffbrand A V; Brenner M K; Noone P
Do double-beta-lactam combinations prolong neutropenia in patients undergoing chemotherapy or bone marrow transplantation for hematological disease?
Antimicrobial agents and chemotherapy 1989;33(4):503-7.
1989: Reittie J E; Gottlieb D; Heslop H E; Leger O; Drexler H G; Hazlehurst G; Hoffbrand A V; Prentice H G; Brenner M K
Endogenously generated activated killer cells circulate after autologous and allogeneic marrow transplantation but not after chemotherapy.
Blood 1989;73(5):1351-8.
1989: Leber B F; Amlot P; Hoffbrand A V; Norton J D
Rearrangement of TCR gamma chain gene involving JP1 suggests early thymocyte origin of peripheral T-cell lymphoma.
European journal of haematology 1989;42(4):368-74.
1989: Barradas M A; Jeremy J Y; Kontoghiorghes G J; Mikhailidis D P; Hoffbrand A V; Dandona P
Iron chelators inhibit human platelet aggregation, thromboxane A2 synthesis and lipoxygenase activity.
FEBS letters 1989;245(1-2):105-9.
1989: Wonke B; Hoffbrand A V; Aldouri M; Wickens D; Flynn D; Stearns M; Warner P
Reversal of desferrioxamine induced auditory neurotoxicity during treatment with Ca-DTPA.
Archives of disease in childhood 1989;64(1):77-82.
1989: Rassam S M; Roderick P; al-Hakim I; Hoffbrand A V
A myelokathexis-like variant of myelodysplasia.
European journal of haematology 1989;42(1):99-102.
1989: Mire-Sluis A R; Hoffbrand A V; Wickremasinghe R G
The binding of ligands to the 55 kDa component of the interleukin-2 receptor triggers increased turnover of phosphate bound to an 85 kDa protein. Evidence for the role of cyclic AMP.
FEBS letters 1989;243(2):280-4.
1989: Leber B F; Amlot P; Hoffbrand A V; Norton J D
T-cell receptor gene rearrangement in B-cell non-Hodgkin's lymphoma: correlation with methylation and expression.
Leukemia research 1989;13(6):473-81.
1989: Wonke B; Hoffbrand A V; Aldouri M A; Ward S E
Cardiac complications in homozygous beta-thalassemia.
Progress in clinical and biological research 1989;309():51-6.
1989: Kontoghiorghes G J; Bartlett A N; Hoffbrand A V
Prospects for effective oral iron chelation therapy in man with 1,2-dimethyl-3-hydroxypyrid-4-one and other alpha-ketohydroxypyridines.
Progress in clinical and biological research 1989;309():107-14.
1989: O'Connor N T; Prentice H G; Hoffbrand A V
Prevention of urate nephropathy in the tumour lysis syndrome.
Clinical and laboratory haematology 1989;11(2):97-100.
1989: Drexler H G; Gignac S M; Hoffbrand A V; Leber B F; Norton J; Lok M S; Minowada J
Characterization of Hodgkin's disease derived cell line HDLM-2.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1989;117():75-82.
1989: Ganeshaguru K; Piga A; Latini L; Hoffbrand A V
Inability of poly-ADP-ribosylation inhibitors to protect peripheral blood lymphocytes from the toxic effects of ADA inhibition.
Advances in experimental medicine and biology 1989;253B():251-8.
1988: Lyttelton M P; Browett P J; Brenner M K; Norton J D; Kolman J L; McGee J O; Hamilton-Dutoit S; Hoffbrand A V; Prentice H G
Prolonged remission of Epstein-Barr virus associated lymphoma secondary to T cell-depleted bone marrow transplantation.
Bone marrow transplantation 1988;3(6):641-6.
1988: Drexler H G; Brenner M K; Gignac S M; Hoffbrand A V
Expression of tartrate-resistant acid phosphatase in B-CLL treated with phorbol ester or phorbol ester plus calcium ionophore.
European journal of haematology 1988;41(3):250-7.
1988: Cordingley F T; Hoffbrand A V; Brenner M K
Cytokine-induced enhancement of the susceptibility of hairy cell leukaemia lymphocytes to natural killer cell lysis.
British journal of haematology 1988;70(1):37-41.
1988: Secker-Walker L M; Cooke H M; Browett P J; Shippey C A; Norton J D; Coustan-Smith E; Hoffbrand A V
Variable Philadelphia breakpoints and potential lineage restriction of bcr rearrangement in acute lymphoblastic leukemia.
Blood 1988;72(2):784-91.
1988: Jeremy J Y; Kontoghiorghes G J; Hoffbrand A V; Dandona P
The iron chelators desferrioxamine and 1-alkyl-2-methyl-3-hydroxypyrid-4-ones inhibit vascular prostacyclin synthesis in vitro.
The Biochemical journal 1988;254(1):239-44.
1988: Sage R; Hann I; Prentice H G; Devereux S; Corringham R; Hoffbrand A V; Blacklock H; Stirling L; Guimaraes M; Trikka E
A randomized trial of empirical antibiotic therapy with one of four beta-lactam antibiotics in combination with netilmicin in febrile neutropenic patients.
The Journal of antimicrobial chemotherapy 1988;22(2):237-47.
1988: Porfiri E; Hoffbrand A V; Wickremasinghe R G
Granulocytic differentiation of HL60 human promyelocytic leukemia cells is preceded by a reduction in levels of inositol lipid-derived second messengers.
Experimental hematology 1988;16(7):641-6.
1988: Guimaraes J E; Berney J J; Broxmeyer H E; Hoffbrand A V; Francis G E
Acidic isoferritin stimulates differentiation of normal granulomonocytic progenitors.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(7):466-71.
1988: Drexler H G; Leber B F; Norton J; Yaxley J; Tatsumi E; Hoffbrand A V; Minowada J
Genotypes and immunophenotypes of Hodgkin's disease-derived cell lines.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(6):371-6.
1988: Reittie J E; Poulter L W; Prentice H G; Burns J; Drexler H G; Balfour B; Clarke J; Hoffbrand A V; McGee J O; Brenner M K
Differential recovery of phenotypically and functionally distinct circulating antigen-presenting cells after allogeneic marrow transplantation.
Transplantation 1988;45(6):1084-91.
1988: Heslop H E; Price G M; Prentice H G; Cordingley F T; Webster A D; Hoffbrand A V; Brenner M K
In vitro analysis of the interactions of recombinant IL-2 with regenerating lymphoid and myeloid cells after allogeneic marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(10):3461-6.
1988: Drexler H G; Brenner M K; Coustan-Smith E; Gignac S M; Hoffbrand A V
Analysis of signal transduction in B chronic lymphocytic leukemia cells.
Blood 1988;71(5):1461-9.
1988: Cordingley F T; Bianchi A; Hoffbrand A V; Reittie J E; Heslop H E; Vyakarnam A; Turner M; Meager A; Brenner M K
Tumour necrosis factor as an autocrine tumour growth factor for chronic B-cell malignancies.
Lancet 1988;1(8592):969-71.
1988: Hoffbrand A V; Leber B F; Browett P J; Norton J D
Mixed acute leukaemias.
Blood reviews 1988;2(1):9-15.
1988: Browett P J; Pattinson J; Pinkney J; Hoffbrand A V; Norton J D
Gene probe analysis demonstrates independent clonal evolution of co-existent chronic myeloid and chronic lymphocytic leukaemia.
European journal of haematology 1988;40(2):181-4.
1988: Drexler H G; Gignac S M; Brenner M K; Coustan-Smith E; Janossy G; Hoffbrand A V
Differential expression of MHC class II antigens in chronic B-cell disorders.
Clinical and experimental immunology 1988;71(2):217-23.
1988: Norton J D; Campana D; Hoffbrand A V; Janossy G; Couston-Smith E; Jani H; Yaxley J C; Prentice H G
Correlation of immunophenotype with rearrangement of T cell antigen receptor beta and gamma genes in acute lymphoblastic leukemia of adults.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1988;2(1):27-34.
1988: Norton J D; Pattinson J; Hoffbrand A V; Jani H; Yaxley J C; Leber B F
Rearrangement and expression of T cell antigen receptor genes in B cell chronic lymphocytic leukemia.
Blood 1988;71(1):178-85.
1988: Bianchi A C; Heslop H E; Drexler H G; Cordingley F T; Turner M; De Mel W C; Hoffbrand A V; Brenner M K
Effects of tumour necrosis factor and alpha interferon on chronic B cell malignancies.
Nouvelle revue française d'hématologie 1988;30(5-6):317-9.
1988: Michalevicz R; Campana D; Katz F E; Janossy G; Hoffbrand A V
Recombinant interleukin 2 and anti-Tac influence the growth of enriched multipotent hemopoietic progenitors: proposed hypotheses for different responses in early and late progenitors.
Leukemia research 1988;12(2):113-21.
1988: Browett P J; Ganeshaguru K; Hoffbrand A V; Norton J D
Absence of Kirsten-ras oncogene activation in B-cell chronic lymphocytic leukemia.
Leukemia research 1988;12(1):25-31.
1988: Browett P J; Hoffbrand A V; Norton J D
Use of the X-chromosome linked hypoxanthine phosphoribosyl transferase gene as a marker of cell monoclonality in hemopoietic malignancies.
Leukemia research 1988;12(4):321-6.
1987: Kontoghiorghes G J; Aldouri M A; Hoffbrand A V; Barr J; Wonke B; Kourouclaris T; Sheppard L
Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one.
British medical journal (Clinical research ed.) 1987;295(6612):1509-12.
1987: Norton J D; Campana D; Hoffbrand A V; Janossy G; Coustan-Smith E; Jani H; Yaxley J C; Prentice H G
Rearrangement of immunoglobulin and T cell antigen receptor genes in acute myeloid leukemia with lymphoid-associated markers.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(11):757-61.
1987: Evans J P; Wickremasinghe R G; Hoffbrand A V
Detection of tyrosine protein kinase substrates in fresh leukemia cells and normal blood cells using an immunoblotting technique.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(11):782-5.
1987: Aldouri M A; Wonke B; Hoffbrand A V; Flynn D M; Laulicht M; Fenton L A; Scheuer P J; Kibbler C C; Allwood C A; Brown D
Iron state and hepatic disease in patients with thalassaemia major, treated with long term subcutaneous desferrioxamine.
Journal of clinical pathology 1987;40(11):1353-9.
1987: Drexler H G; Brenner M K; Coustan-Smith E; Wickremasinghe R G; Hoffbrand A V
Synergistic action of calcium ionophore A23187 and phorbol ester TPA on B-chronic lymphocytic leukemia cells.
Blood 1987;70(5):1536-42.
1987: Mire-Sluis A R; Hoffbrand A V; Wickremasinghe R G
Evidence that guanine-nucleotide binding regulatory proteins couple cell-surface receptors to the breakdown of inositol-containing lipids during T-lymphocyte mitogenesis.
Biochemical and biophysical research communications 1987;148(3):1223-31.
1987: Hall B S; Hoffbrand A V; Wickremasinghe R G
Two major tyrosine protein kinases of resting human T lymphocytes are down-regulated following mitotic stimulation.
FEBS letters 1987;223(1):6-10.
1987: Dearden C E; Matutes E; Hoffbrand A V; Ganeshaguru K; Brozovic M; Williams H J; Traub N; Mills M; Linch D C; Catovsky D
Membrane phenotype and response to deoxycoformycin in mature T cell malignancies.
British medical journal (Clinical research ed.) 1987;295(6603):873-5.
1987: Wimperis J Z; Brenner M K; Drexler H G; Hoffbrand A V; Prentice H G
Rapid recovery of helper activity following T cell depleted allogeneic marrow transplant.
Clinical and experimental immunology 1987;69(3):601-10.
1987: Drexler H G; Coustan-Smith E; Gignac S M; Jani H; Hoffbrand A V
In vitro induction of myeloid surface markers in a rare case of acute leukemia.
American journal of hematology 1987;25(4):441-8.
1987: Wickremasinghe R G; Mire-Sluis A R; Hoffbrand A V
Interleukin-2 binding to activated human T lymphocytes triggers generation of cyclic AMP but not of inositol phosphates.
FEBS letters 1987;220(1):52-6.
1987: Drexler H G; Brenner M K; Wimperis J Z; Gignac S M; Janossy G; Prentice H G; Hoffbrand A V
CD5-positive B cells after T cell depleted bone marrow transplantation.
Clinical and experimental immunology 1987;68(3):662-8.
1987: Kontoghiorghes G J; Aldouri M A; Sheppard L; Hoffbrand A V
1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active chelator for treatment of iron overload.
Lancet 1987;1(8545):1294-5.
1987: Evans J P; Wickremasinghe R G; Hoffbrand A V
Tyrosine protein kinase substrates in Philadelphia-positive human chronic granulocytic leukemia derived cell lines (K562 and BV173): detection by using an immunoblotting technique.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1987;1(6):524-5.
1987: Grob J P; Grundy J E; Prentice H G; Griffiths P D; Hoffbrand A V; Hughes M D; Tate T; Wimperis J Z; Brenner M K
Immune donors can protect marrow-transplant recipients from severe cytomegalovirus infections.
Lancet 1987;1(8536):774-6.
1987: Brenner M K; Vyakarnam A; Reittie J E; Wimperis J Z; Grob J P; Hoffbrand A V; Prentice H G
Human large granular lymphocytes induce immunoglobulin synthesis after bone marrow transplantation.
European journal of immunology 1987;17(1):43-7.
1987: Mire-Sluis A R; Wickremasinghe R G; Hoffbrand A V; Timms A M; Francis G E
Human T lymphocytes stimulated by phytohaemagglutinin undergo a single round of cell division without a requirement for interleukin-2 or accessory cells.
Immunology 1987;60(1):7-12.
1987: Ganeshaguru K; Ho A D; Piga A; Catovsky D; Hoffbrand A V
Biochemical mechanisms of deoxycoformycin toxicity in chronic leukemias.
Leukemia research 1987;11(10):941-5.
1987: Katz F E; Michalevicz R; Lam G; Hoffbrand A V; Goldman J M
Effect of platelet-derived growth factor on enriched populations of haemopoietic progenitors from patients with chronic myeloid leukaemia.
Leukemia research 1987;11(4):339-44.
1987: Chatterjee R; Katz M; Wonke B; Hoffbrand A V; Politis D
Induction of puberty in patients with beta-thalassemia major.
Birth defects original article series 1987;23(5A):453-8.
1986: Gilmore M J; Patterson J; Ivory K; Brenner M K; Graphakos S; Janossy G; Hoffbrand A V; Prentice H G
Standardization of T-cell depletion in HLA matched bone marrow transplantation.
British journal of haematology 1986;64(1):69-75.
1986: Brenner M K; Wimperis J Z; Reittie J E; Patterson J; Asherson G L; Hoffbrand A V; Prentice H G
Recovery of immunoglobulin isotypes following T-cell depleted allogeneic bone marrow transplantation.
British journal of haematology 1986;64(1):125-32.
1986: Brenner M K; Reittie J E; Grob J P; Wimperis J Z; Stephens S; Patterson J; Hoffbrand A V; Prentice H G
The contribution of large granular lymphocytes to B cell activation and differentiation after T-cell-depleted allogeneic bone marrow transplantation.
Transplantation 1986;42(3):257-61.
1986: Wimperis J Z; Berry N J; Brenner M K; Grundy J; Hoffbrand A V; Griffiths P D; Prentice H G
Production of anti-cytomegalovirus antibody following T-cell depleted bone marrow transplant.
British journal of haematology 1986;63(4):659-64.
1986: Michalevicz R; Katz F; Stroobant P; Janossy G; Tindle R W; Hoffbrand A V
Platelet-derived growth factor stimulates growth of highly enriched multipotent haemopoietic progenitors.
British journal of haematology 1986;63(3):591-8.
1986: Wimperis J Z; Brenner M K; Prentice H G; Reittie J E; Karayiannis P; Griffiths P D; Hoffbrand A V
Transfer of a functioning humoral immune system in transplantation of T-lymphocyte-depleted bone marrow.
Lancet 1986;1(8477):339-43.
1986: Chiu H Y; Flynn D M; Hoffbrand A V; Politis D
Infection with Yersinia enterocolitica in patients with iron overload.
British medical journal (Clinical research ed.) 1986;292(6513):97.
1985: Guimaraes J E; Francis G E; Berney J J; Wing M A; Hoffbrand A V
Differentiation of human acute myeloid leukaemia cells in response to exogenous and endogenous stimuli: different patterns of response suggested by a bioassay system.
Leukemia research 1985;9(7):869-78.
1985: Michalevicz R; Taheri M R; Katz F; Hoffbrand A V
The effect of the leukemic cell line HL60 and acute myeloblastic leukemic cells before and after induction of differentiation on normal pluripotent hematopoietic progenitors (CFU-GEMM).
Leukemia research 1985;9(4):441-8.
1984: Blacklock H A; Katz F; Michalevicz R; Hazlehurst G R; Davies L; Prentice H G; Hoffbrand A V
A and B blood group antigen expression on mixed colony cells and erythroid precursors: relevance for human allogeneic bone marrow transplantation.
British journal of haematology 1984;58(2):267-76.
1984: Guimaraes J E; Berney J J; Francis G E; Hoffbrand A V
The identification of mixed granulocytic-erythrocytic colonies in vitro.
Experimental hematology 1984;12(7):535-8.
1984: Mieli-Vergani G; Vergani D; White Y; Mowat A P; Wonke B; Kennedy C J; Karameau A; Politis D; Laulicht M; Hoffbrand A V
Hepatitis B virus infection in thalassaemia major treated in London and Athens.
British medical journal (Clinical research ed.) 1984;288(6433):1804.
1984: Francis G E; Ho A D; Gray D A; Berney J J; Wing M A; Yaxley J J; Ma D D; Hoffbrand A V
DNA strand breakage and ADP-ribosyl transferase mediated DNA ligation during stimulation of human bone marrow cells by granulocyte-macrophage colony stimulating activity.
Leukemia research 1984;8(3):407-15.
1983: Gilmore M J; Prentice H G; Jones E P; Blacklock H A; Tidman N; Schey S; Goldstein G; Janossy G; Hoffbrand A V
Allogeneic bone marrow transplantation: the monitoring of granulocyte macrophage colonies following the collection of bone marrow mononuclear cells and after the subsequent in-vitro cytolysis of OKT3 positive lymphocytes.
British journal of haematology 1983;55(4):587-93.
1983: Francis G E; Gray D A; Berney J J; Wing M A; Guimaraes J E; Hoffbrand A V
Role of ADP-ribosyl transferase in differentiation of human granulocyte-macrophage progenitors to the macrophage lineage.
Blood 1983;62(5):1055-62.
1983: Francis G E; Wing M A; Miller E J; Berney J J; Wonke B; Hoffbrand A V
Use of bone-marrow culture in prediction of acute leukaemic transformation in preleukaemia.
Lancet 1983;1(8339):1409-12.
1983: Gilmore M J; Prentice H G; Corringham R E; Blacklock H A; Hoffbrand A V
A technique for the concentration of nucleated bone marrow cells for in vitro manipulation or cryopreservation using the IBM 2991 blood cell processor.
Vox sanguinis 1983;45(4):294-302.
1982: Blacklock H A; Gilmore M J; Prentice H G; Hazlehurst G R; Evans J P; Ma D D; Knight C B; Hoffbrand A V
ABO-incompatible bone-marrow transplantation: removal of red blood cells from donor marrow avoiding recipient antibody depletion.
Lancet 1982;2(8307):1061-4.
1982: Chapman R W; Hussain M A; Gorman A; Laulicht M; Politis D; Flynn D M; Sherlock S; Hoffbrand A V
Effect of ascorbic acid deficiency on serum ferritin concentration in patients with beta-thalassaemia major and iron overload.
Journal of clinical pathology 1982;35(5):487-91.
1982: Chapman R W; Gorman A; Laulicht M; Hussain M A; Sherlock S; Hoffbrand A V
Binding of serum ferritin to concanavalin A in patients with iron overload and with chronic liver disease.
Journal of clinical pathology 1982;35(5):481-6.
1982: Gilmore M J; Prentice H G; Blacklock H A; Janossy G; Hoffbrand A V
A technique for rapid isolation of bone marrow mononuclear cells using Ficoll-Metrizoate and the IBM 2991 blood cell processor.
British journal of haematology 1982;50(4):619-26.
1982: Hann I M; Prentice H G; Corringham R; Blacklock H A; Keaney M; Shannon M; Noone P; Gascoigne E; Fox J; Boesen E; Szawatkowski M; Hoffbrand A V
Ketoconazole versus nystatin plus amphotericin B for fungal prophylaxis in severely immunocompromised patients.
Lancet 1982;1(8276):826-9.
1982: Chapman R W; Bassendine M F; Laulicht M; Gorman A; Thomas H C; Sherlock S; Hoffbrand A V
Serum ferritin and binding of serum ferritin to concanavalin A as a tumor marker in patients with primary liver cell cancer and chronic liver disease.
Digestive diseases and sciences 1982;27(2):111-6.
1982: Guimaraes J E; Francis G E; Bol S J; Berney J J; Hoffbrand A V
Differentiation restriction in the neutrophil-granulocyte, macrophage, eosinophil-granulocyte pathway: analysis by equilibrium density centrifugation.
Leukemia research 1982;6(6):791-800.
1982: Janossy G; Tidman N; Bradstock K F; Hoffbrand A V; Bollum F J
Terminal transferase positive cells in the human bone marrow and thymus.
Advances in experimental medicine and biology 1982;145():161-76.
1982: Francis G E; Berney J J; Wing M A; Tuma G A; Hoffbrand A V
Relative and absolute deficiency of bone marrow endogenous colony stimulating activity in acute myeloid leukemia: relation to response to chemotherapy.
Leukemia research 1982;6(2):165-73.
1982: Francis G E; Guimaraes J E; Granger S; Berney J J; Tidman N; Wing M A; Janossy G; Hoffbrand A V
Distinct T lymphocyte subsets affect granulo-monocytic differentiation and proliferation.
Stem cells 1982;2(2):76-87.
1982: Flynn D M; Hoffbrand A V; Politis D
Subcutaneous desferrioxamine: the effect of three years' treatment on liver, iron, serum ferritin, and comments on echocardiography.
Birth defects original article series 1982;18(7):347-53.
1981: Bradstock K F; Pizzolo G; Papageorgiou E S; Cetto G L; Prentice H G; Ganeshaguru K; Prentice A G; Smith A; Chilosi M; Ambrosetti A; Hoffbrand A V
Terminal transferase expression in relapsed acute myeloid leukaemia.
British journal of haematology 1981;49(4):621-7.
1981: Francis G E; Tuma G A; Berney J J; Hoffbrand A V
Sensitivity of acute myeloid leukaemia cells to colony stimulating activity: relation to response to chemotherapy.
British journal of haematology 1981;49(2):259-67.
1981: Francis G E; Rhodes E G; Berney J J; Wing M A; Hoffbrand A V
Bone marrow endogenous colony stimulating factor(s): relation to granulopoiesis in vivo.
Experimental hematology 1981;9(4):332-45.
1981: Bradstock K F; Hoffbrand A V; Ganeshaguru K; Llewellin P; Patterson K; Wonke B; Prentice A G; Bennett M; Pizzolo G; Bollum F J; Janossy G
Terminal deoxynucleotidyl transferase expression in acute non-lymphoid leukaemia: an analysis by immunofluorescence.
British journal of haematology 1981;47(1):133-43.
1981: Bradstock K F; Janossy G; Hoffbrand A V; Ganeshaguru K; Llewellin P; Prentice H G; Bollum F J
Immunofluorescent and biochemical studies of terminal deoxynucleotidyl transferase in treated acute leukaemia.
British journal of haematology 1981;47(1):121-31.
1981: Bradstock K F; Janossy G; Tidman N; Papageorgiou E S; Prentice H G; Willoughby M; Hoffbrand A V
Immunological monitoring of residual disease in treated thymic acute lymphoblastic leukaemia.
Leukemia research 1981;5(4-5):301-9.
1981: Francis G E; Berney J J; Bodger M P; Bol S J; Wing M A; Hoffbrand A V
Clone size potential and sensitivity to colony-stimulating activity: differentiation-linked properties of granulocyte-macrophage progenitor cells.
Stem cells 1981;1(2):124-39.
1981: Ganeshaguru K; Lee N; Llewellin P; Prentice H G; Hoffbrand A V; Catovsky D; Habeshaw J A; Robinson J; Greaves M F
Adenosine deaminase concentrations in leukaemia and lymphoma: relation to cell phenotypes.
Leukemia research 1981;5(3):215-22.
1980: Bradstock K F; Papageorgiou E S; Janossy G; Hoffbrand A V; Willoughby M L; Roberts P D; Bollum F J
Detection of leukaemic lymphoblasts in CSF by immunofluorescence for terminal transferase.
Lancet 1980;1(8178):1144.
1980: Francis G E; Berney J J; Tuma G A; Wing M A; Hoffbrand A V
Divergent sensitivities of leukaemic cells to human placental conditioned medium and leucocyte feeder layers.
Leukemia research 1980;4(6):531-6.

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