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Ronald Hoffman

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John Mascarenhas; Vesna Najfeld; Bruce Petersen; Judith D Goldberg; Tsivia Hochman; Timmy Li; Min Lu; Ronald Hoffman
A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF).
Jane Lew; Steven J Frucht; Ronald Hoffman; Marina Kremyanskaya; John Mascarenhas
Hemichorea in a patient with JAK2V617F blood cells.
Xiaoli Wang; Paul Roda; Joseph Tripodi; Amanda Blouin; Ronald Hoffman; Marina Kremyanskaya; Vesna Najfeld
BCR-ABL1 is a secondary event after JAK2V617F in patients with polycythemia vera who develop chronic myeloid leukemia.

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All Publications

2013: John Mascarenhas; Vesna Najfeld; Bruce Petersen; Judith D Goldberg; Tsivia Hochman; Timmy Li; Min Lu; Ronald Hoffman
A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF).
British journal of haematology 2013;161(1):68-75.
2013: Jane Lew; Steven J Frucht; Ronald Hoffman; Marina Kremyanskaya; John Mascarenhas
Hemichorea in a patient with JAK2V617F blood cells.
Blood 2013;121(7):1239-40.
2013: Xiaoli Wang; Paul Roda; Joseph Tripodi; Amanda Blouin; Ronald Hoffman; Marina Kremyanskaya; Vesna Najfeld
BCR-ABL1 is a secondary event after JAK2V617F in patients with polycythemia vera who develop chronic myeloid leukemia.
Blood 2013;121(7):1238-9.
2013: Camelia Iancu-Rubin; Thomas Kraus; Goar Mosoyan; Victoria Sung; Jiapeng Wang; Ronald Hoffman
Stromal cell-mediated inhibition of erythropoiesis can be attenuated by Sotatercept (ACE-011), an activin receptor type II ligand trap.
Experimental hematology 2013;41(2):155-166.e17.
2012: John Mascarenhas; Vesna Najfeld; Bruce Petersen; Nikolai Podoltsev; Raajit Rampal; Farhad Ravandi; Gail Roboz; Martin Tallman; Omar Abdel-Wahab; Dan Douer; Eric Feldman; Mark L Heaney; Elizabeth Hexner; Ronald Hoffman; Ross Levine
Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium.
Leukemia research 2012;36(12):1500-4.
2012: Xiaoli Wang; Rona Weinberg; Fei Ye; Yan Li; Min Lu; Vesna Najfeld; Attilio Orazi; Sonam Prakash; Paul Roda; Myron Schwartz; Joseph Tripodi; Ronald Hoffman
Spleens of myelofibrosis patients contain malignant hematopoietic stem cells.
The Journal of clinical investigation 2012;122(11):3888-99.
2012: Jeffrey A Glassberg; Ronald Hoffman; Annie Chow; Michael R DeBaun; Juan Wisnivesky; Lynne D Richardson
Wheezing and asthma are independent risk factors for increased sickle cell disease morbidity.
British journal of haematology 2012;159(4):472-9.
2012: Min Lu; John Mascarenhas; Goar Mosoyan; Vesna Najfeld; Joseph Tripodi; Xiaoli Wang; Marina Kremyanskaya; Yan Li; Ronald Hoffman
Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-α 2a specifically targets JAK2V617F-positive polycythemia vera cells.
Blood 2012;120(15):3098-105.
2012: Min Lu; Ronald Hoffman
p53 as a target in myeloproliferative neoplasms.
Oncotarget 2012;3(10):1052-3.
2012: Camelia Iancu-Rubin; John Mascarenhas; Goar Mosoyan; Faye Feller; David Gajzer; Ronald Hoffman
Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation.
Experimental hematology 2012;40(7):564-74.
2012: John Mascarenhas; Ronald Hoffman
Ruxolitinib: the first FDA approved therapy for the treatment of myelofibrosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(11):3008-14.
2012: Marina Kremyanskaya; John Mascarenhas; Ronald Hoffman
Why does my patient have erythrocytosis?
Hematology/oncology clinics of North America 2012;26(2):267-83, vii-viii.
2011: Camelia Iancu-Rubin; David Gajzer; Joseph Tripodi; Vesna Najfeld; Ronald E Gordon; Ronald Hoffman; George F Atweh
Down-regulation of stathmin expression is required for megakaryocyte maturation and platelet production.
Blood 2011;117(17):4580-9.
2011: Pratima Chaurasia; Dmitriy Berenzon; Ronald Hoffman
Chromatin-modifying agents promote the ex vivo production of functional human erythroid progenitor cells.
Blood 2011;117(17):4632-41.
2011: Vesna Najfeld; Nathaniel Wisch; John Mascarenhas; Leonard Issa; Joseph Tripodi; Manpreet Sidhu; Ronald Hoffman
Development of t(8;21) and RUNX1-RUNX1T1 in the Philadelphia-positive clone of a patient with chronic myelogenous leukemia: additional evidence for multiple steps involved in disease progression.
Cancer genetics 2011;204(3):165-70.
2010: Xiaoli Wang; Wei Zhang; Joseph Tripodi; Min Lu; Mingjiang Xu; Vesna Najfeld; Yan Li; Ronald Hoffman
Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells.
Blood 2010;116(26):5972-82.
2010: Min Lu; Jiapeng Wang; Yan Li; Dmitriy Berenzon; Xiaoli Wang; John Mascarenhas; Mingjiang Xu; Ronald Hoffman
Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon α specifically targets JAK2V617F-positive polycythemia vera hematopoietic progenitor cells.
Blood 2010;116(20):4284-7.
2010: John Mascarenhas; Ronald Hoffman
Myeloproliferative neoplasms: new translational therapies.
The Mount Sinai journal of medicine, New York 2010;77(6):667-83.
2010: Hiroto Araki; John P Chute; Benjamin Petro; Lisa Halliday; Ronald Hoffman; Nadim Mahmud
Bone marrow CD34+ cells expanded on human brain endothelial cells reconstitute lethally irradiated baboons in a variable manner.
Leukemia & lymphoma 2010;51(6):1121-7.
2010: Min Lu; Wei Zhang; Yan Li; Dmitriy Berenzon; Xiaoli Wang; Jiapeng Wang; John Mascarenhas; Mingjiang Xu; Ronald Hoffman
Interferon-alpha targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway.
Experimental hematology 2010;38(6):472-80.
2010: Barbara Ghinassi; Fabrizio Martelli; Maria Verrucci; Emanuela D'Amore; Giovanni Migliaccio; Alessandro Maria Vannucchi; Ronald Hoffman; Anna Rita Migliaccio
Evidence for organ-specific stem cell microenvironments.
Journal of cellular physiology 2010;223(2):460-70.
2010: Sool Yeon Cho; Mingjiang Xu; Julia Roboz; Min Lu; John Mascarenhas; Ronald Hoffman
The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms.
Cancer research 2010;70(8):3402-10.
2010: Vincent Seaman; Steve M Dearwent; Debra Gable; Brian Lewis; Susan Metcalf; Ken Orloff; Bruce Tierney; Jane Zhu; James Logue; David Marchetto; Stephen Ostroff; Ronald Hoffman; Mingjiang Xu; David Carey; Porat Erlich; Glenn Gerhard; Paul Roda; Joseph Iannuzzo; Robert Lewis; John Mellow; Linda Mulvihill; Zachary Myles; Manxia Wu; Arthur Frank; Carol Ann Gross-Davis; Judith Klotz; Adam Lynch; Joel Weissfeld; Rona Weinberg; Henry Cole
A multidisciplinary investigation of a polycythemia vera cancer cluster of unknown origin.
International journal of environmental research and public health 2010;7(3):1139-52.
2010: Joseph Tripodi; Ronald Hoffman; Vesna Najfeld; Rona Weinberg
Frequency of heterozygous TET2 deletions in myeloproliferative neoplasms.
Cancer management and research 2010;2():219-23.
2009: Selcuk Sozer; Takefumi Ishii; M Isabel Fiel; Jiapeng Wang; Xiaoli Wang; Wei Zhang; Jim Godbold; Mingjiang Xu; Ronald Hoffman
Human CD34+ cells are capable of generating normal and JAK2V617F positive endothelial like cells in vivo.
Blood cells, molecules & diseases 2009;43(3):304-12.
2009: Xiaoli Wang; Wei Zhang; Takefumi Ishii; Selcuk Sozer; Jiapeng Wang; Mingjiang Xu; Ronald Hoffman
Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents.
Cancer research 2009;69(19):7612-8.
2009: Xiaoli Wang; Amanda LeBlanc; Steven Gruenstein; Mingjiang Xu; John Mascarenhas; Brenda Panzera; Nathaniel Wisch; Charles Parker; Judith D Goldberg; Josef Prchal; Ronald Hoffman; Vesna Najfeld
Clonal analyses define the relationships between chromosomal abnormalities and JAK2V617F in patients with Ph-negative myeloproliferative neoplasms.
Experimental hematology 2009;37(10):1194-200.
2009: J Wang; Takefumi Ishii; Wei Zhang; Selcuk Sozer; Yun Dai; J Mascarenhas; V Najfeld; Z J Zhao; Ronald Hoffman; N Wisch; Mingjiang Xu
Involvement of mast cells by the malignant process in patients with Philadelphia chromosome negative myeloproliferative neoplasms.
Leukemia 2009;23(9):1577-86.
2009: Takefumi Ishii; Jiapeng Wang; Wei Zhang; John Mascarenhas; Ronald Hoffman; Ying Dai; Nathaniel Wisch; Mingjiang Xu
Pivotal role of mast cells in pruritogenesis in patients with myeloproliferative disorders.
Blood 2009;113(23):5942-50.
2009: Selcuk Sozer; M Isabel Fiel; Thomas Schiano; Mingjiang Xu; John Mascarenhas; Ronald Hoffman
The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome.
Blood 2009;113(21):5246-9.
2009: Vincent Seaman; Aisha Jumaan; Emad Yanni; Brian Lewis; Jonathan Neyer; Paul Roda; Mingjiang Xu; Ronald Hoffman
Use of molecular testing to identify a cluster of patients with polycythemia vera in eastern Pennsylvania.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(2):534-40.
2008: Selcuk Sozer; Xiaoli Wang; Wei Zhang; M Isabel Fiel; Takefumi Ishii; Jiapeng Wang; Nathaniel Wisch; Mingjiang Xu; Ronald Hoffman
Circulating angiogenic monocyte progenitor cells are reduced in JAK2V617F high allele burden myeloproliferative disorders.
Blood cells, molecules & diseases 2008;41(3):284-91.
2008: Sandeep Chunduri; Sujata Gaitonde; Stefan O Ciurea; Ronald Hoffman; Damiano Rondelli
Pulmonary extramedullary hematopoiesis in patients with myelofibrosis undergoing allogeneic stem cell transplantation.
Haematologica 2008;93(10):1593-5.
2008: Stefan O Ciurea; Barry Sadegi; AC Wilbur; Victoria Alagiozian-Angelova; Sujata Gaitonde; LC Dobogai; Luke P Akard; Ronald Hoffman; Damiano Rondelli
Effects of extensive splenomegaly in patients with myelofibrosis undergoing a reduced intensity allogeneic stem cell transplantation.
British journal of haematology 2008;141(1):80-3.
2007: Takefumi Ishii; Yan Zhao; Jun Shi; Selcuk Sozer; Ronald Hoffman; Mingjiang Xu
T cells from patients with polycythemia vera elaborate growth factors which contribute to endogenous erythroid and megakaryocyte colony formation.
Leukemia 2007;21(12):2433-41.
2007: Takefumi Ishii; Yan Zhao; Selcuk Sozer; Jun Shi; Wei Zhang; Ronald Hoffman; Mingjiang Xu
Behavior of CD34+ cells isolated from patients with polycythemia vera in NOD/SCID mice.
Experimental hematology 2007;35(11):1633-40.
2007: Stefan O Ciurea; Delwin Merchant; Nadim Mahmud; Takefumi Ishii; Yan Zhao; WENYANG HU; Edward Bruno; Giovanni Barosi; Mingjiang Xu; Ronald Hoffman
Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis.
Blood 2007;110(3):986-93.
2007: Stefan O Ciurea; Ronald Hoffman
Cytokines for the treatment of thrombocytopenia.
Seminars in hematology 2007;44(3):166-82.
2007: Jun Shi; Yan Zhao; Takefumi Ishii; WENYANG HU; Selcuk Sozer; Wei Zhang; Edward Bruno; Valerie Lindgren; Mingjiang Xu; Ronald Hoffman
Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis.
Cancer research 2007;67(13):6417-24.
2007: WENYANG HU; Yan Zhao; Takefumi Ishii; Selcuk Sozer; Jun Shi; Wei Zhang; Edward Bruno; Ronald Hoffman; Mingjiang Xu
Haematopoietic cell lineage distribution of MPLW515L/K mutations in patients with idiopathic myelofibrosis.
British journal of haematology 2007;137(4):378-9.
2007: Hiroto Araki; Kazumi Yoshinaga; Piernicola Boccuni; Yan Zhao; Ronald Hoffman; Nadim Mahmud
Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential.
Blood 2007;109(8):3570-8.
2007: Takefumi Ishii; Mingjiang Xu; Yan Zhao; WENYANG HU; Stefan O Ciurea; E Bruno; Ronald Hoffman
Recurrence of clonal hematopoiesis after discontinuing pegylated recombinant interferon-alpha 2a in a patient with polycythemia vera.
Leukemia 2007;21(2):373-4.
2007: Ronald Hoffman; Josef T Prchal; Scott Samuelson; Stefan O Ciurea; Damiano Rondelli
Philadelphia chromosome-negative myeloproliferative disorders: biology and treatment.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(1 Suppl 1):64-72.
2006: Takefumi Ishii; Edward Bruno; Ronald Hoffman; Mingjiang Xu
Involvement of various hematopoietic-cell lineages by the JAK2V617F mutation in polycythemia vera.
Blood 2006;108(9):3128-34.
2006: Sandeep Chunduri; LC Dobogai; David J Peace; Yogen Saunthararajah; H Y Chen; Nadim Mahmud; John Quigley; Ronald Hoffman; Ellen Jessop; Rakesh Beri; Damiano Rondelli
Comparable kinetics of myeloablation between fludarabine/full-dose busulfan and fludarabine/melphalan conditioning regimens in allogeneic peripheral blood stem cell transplantation.
Bone marrow transplantation 2006;38(7):477-82.
2006: Javaneh Abbasian; Dolores Mahmud; Nadim Mahmud; Sandeep Chunduri; Hiroto Araki; Pavan Reddy; Ronald Hoffman; Mario Arpinati; James L M Ferrara; Damiano Rondelli
Allogeneic T cells induce rapid CD34+ cell differentiation into CD11c+CD86+ cells with direct and indirect antigen-presenting function.
Blood 2006;108(1):203-8.
2006: S Saraf; Yi-Hsiang Chen; LC Dobogai; Nadim Mahmud; David J Peace; Yogen Saunthararajah; Ronald Hoffman; Sandeep Chunduri; Damiano Rondelli
Prolonged responses after autologous stem cell transplantation in African-American patients with multiple myeloma.
Bone marrow transplantation 2006;37(12):1099-102.
2006: Hiroto Araki; Nadim Mahmud; Mohammed Milhem; Rafael Nunez; Mingjiang Xu; Craig Beam; Ronald Hoffman
Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents.
Experimental hematology 2006;34(2):140-9.
2005: Nadim Mahmud; David Rose; Wenxin Pang; Russell Walker; Veena Patil; Nadine Weich; Ronald Hoffman
Characterization of primitive marrow CD34+ cells that persist after a sublethal dose of total body irradiation.
Experimental hematology 2005;33(11):1388-401.
2005: Hongyu Ni; Giovanni Barosi; Damiano Rondelli; Ronald Hoffman
Studies of the site and distribution of CD34+ cells in idiopathic myelofibrosis.
American journal of clinical pathology 2005;123(6):833-9.
2005: Mingjiang Xu; Edward Bruno; Joseph Chao; Stephen Huang; Guido Finazzi; Steven Fruchtman; Uday Popat; Josef T Prchal; Giovanni Barosi; Ronald Hoffman
Constitutive mobilization of CD34+ cells into the peripheral blood in idiopathic myelofibrosis may be due to the action of a number of proteases.
Blood 2005;105(11):4508-15.
2005: Damiano Rondelli; Giovanni Barosi; Andrea Bacigalupo; Josef T Prchal; Uday Popat; Emilio Paolo Alessandrino; Jerry L Spivak; B Douglas Smith; Hans G Klingemann; Steven Fruchtman; Ronald Hoffman
Allogeneic hematopoietic stem-cell transplantation with reduced-intensity conditioning in intermediate- or high-risk patients with myelofibrosis with myeloid metaplasia.
Blood 2005;105(10):4115-9.
2005: Mingjiang Xu; Edward Bruno; Joseph Chao; Hongyu Ni; Valerie Lindgren; Rafael Nunez; Nadim Mahmud; Guido Finazzi; Steven Fruchtman; Uday Popat; Enli Liu; Josef T Prchal; Damiano Rondelli; Giovanni Barosi; Ronald Hoffman
The constitutive mobilization of bone marrow-repopulating cells into the peripheral blood in idiopathic myelofibrosis.
Blood 2005;105(4):1699-705.
2004: Mohammed Milhem; Nadim Mahmud; Donald Lavelle; Hiroto Araki; Joseph DeSimone; Yogen Saunthararajah; Ronald Hoffman
Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.
Blood 2004;103(11):4102-10.
2004: Nadim Mahmud; Wenxin Pang; Carrington Cobbs; Prasad Alur; Jade Borneman; Robert Dodds; Michael Archambault; Steven M Devine; Julius Turian; Amelia Bartholomew; P Vanguri; Alastair Mackay; Randell Young; Ronald Hoffman
Studies of the route of administration and role of conditioning with radiation on unrelated allogeneic mismatched mesenchymal stem cell engraftment in a nonhuman primate model.
Experimental hematology 2004;32(5):494-501.
2003: Yogen Saunthararajah; Cheryl A Hillery; Donald Lavelle; Robert Molokie; Louise Dorn; Linda Bressler; Stefana Gavazova; Yi-Hsiang Chen; Ronald Hoffman; Joseph DeSimone
Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell adhesion, and hematopoietic differentiation in patients with sickle cell disease.
Blood 2003;102(12):3865-70.
2003: Koen van Besien; Steven M Devine; Amittha Wickrema; Ellen Jessop; K Amin; M Yassine; Vera Maynard; Wendy Stock; David J Peace; Farhad Ravandi; Yi-Hsiang Chen; Ronald Hoffman; J Sossman
Regimen-related toxicity after fludarabine-melphalan conditioning: a prospective study of 31 patients with hematologic malignancies.
Bone marrow transplantation 2003;32(5):471-6.
2003: Koen van Besien; Steven M Devine; Amittha Wickrema; Ellen Jessop; K Amin; M Yassine; Vera Maynard; Wendy Stock; David J Peace; Farhad Ravandi; Yi-Hsiang Chen; T Cheung; S Vijayakumar; Ronald Hoffman; Jeffrey A Sosman
Safety and outcome after fludarabine-thiotepa-TBI conditioning for allogeneic transplantation: a prospective study of 30 patients with hematologic malignancies.
Bone marrow transplantation 2003;32(1):9-13.
2003: Steven M Devine; Carrington Cobbs; Matt Jennings; Amelia Bartholomew; Ronald Hoffman
Mesenchymal stem cells distribute to a wide range of tissues following systemic infusion into nonhuman primates.
Blood 2003;101(8):2999-3001.
2002: Hélène A Elicha Gussin; Farideh Z Bischoff; Ronald Hoffman; Sherman Elias
Endothelial precursor cells in the peripheral blood of pregnant women.
Journal of the Society for Gynecologic Investigation 2002;9(6):357-61.
2002: Nadim Mahmud; Paul Weiss; Fei Li; Ronald Hoffman
Primate skeletal muscle contains cells capable of sustaining in vitro hematopoiesis.
Experimental hematology 2002;30(8):925-36.
2002: Ronald Hoffman
Quality of life issues in patients with essential thrombocythemia and polycythemia vera.
Seminars in oncology 2002;29(3 Suppl 10):3-9.
2002: Steven M Devine; Ronald Hoffman; Amit Verma; Rajul Shah; Basil A Bradlow; Wendy Stock; Vera Maynard; Ellen Jessop; David J Peace; Marianne Huml; Deana Thomason; Yi-Hsiang Chen; Koen van Besien
Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia.
Blood 2002;99(6):2255-8.
2002: Amelia Bartholomew; Cord Sturgeon; Mandy Siatskas; Karen Ferrer; Kevin McIntosh; Sheila Patil; Wayne Hardy; Steven M Devine; David S Ucker; Robert Deans; Annemarie Moseley; Ronald Hoffman
Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.
Experimental hematology 2002;30(1):42-8.
2001: Amelia Bartholomew; Sheila Patil; A Mackay; M Nelson; D Buyaner; Wayne Hardy; Joseph Mosca; Cord Sturgeon; M Siatskas; Nadim Mahmud; Karen Ferrer; Robert Deans; Annemarie Moseley; Ronald Hoffman; Steven M Devine
Baboon mesenchymal stem cells can be genetically modified to secrete human erythropoietin in vivo.
Human gene therapy 2001;12(12):1527-41.
2001: Ignatius Gomes; T T Sharma; Nadim Mahmud; J D Kapp; Seby Edassery; Noreen Fulton; Jie Liang; Ronald Hoffman; Carol A Westbrook
Highly abundant genes in the transcriptosome of human and baboon CD34 antigen-positive bone marrow cells.
Blood 2001;98(1):93-9.
2001: Nadim Mahmud; Steven M Devine; K P Weller; S Parmar; Cord Sturgeon; MC Nelson; Terry A Hewett; Ronald Hoffman
The relative quiescence of hematopoietic stem cells in nonhuman primates.
Blood 2001;97(10):3061-8.
2001: Steven M Devine; Amelia Bartholomew; Nadim Mahmud; M Nelson; Sheila Patil; Wayne Hardy; Cord Sturgeon; Terry A Hewett; T Chung; Wendy Stock; Dorie A Sher; S Weissman; Karen Ferrer; Joseph Mosca; Robert Deans; Annemarie Moseley; Ronald Hoffman
Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion.
Experimental hematology 2001;29(2):244-55.
2001: Jeffrey A Sosman; Patrick J Stiff; Sue Moss; Patricia Sorokin; Brenda Martone; Robert Bayer; Koen van Besien; Steven M Devine; Wendy Stock; David J Peace; Yi-Hsiang Chen; C Long; David M Gustin; Marlos Viana; Ronald Hoffman
Pilot trial of interleukin-2 with granulocyte colony-stimulating factor for the mobilization of progenitor cells in advanced breast cancer patients undergoing high-dose chemotherapy: expansion of immune effectors within the stem-cell graft and post-stem-cell infusion.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(3):634-44.
2001: A K Sharma; MC Nelson; JE Brandt; M Wessman; Nadim Mahmud; K P Weller; Ronald Hoffman
Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi.
Blood 2001;97(2):426-34.
2000: E S Rosler; JE Brandt; JP Chute; Ronald Hoffman
An in vivo competitive repopulation assay for various sources of human hematopoietic stem cells.
Blood 2000;96(10):3414-21.
2000: Jeffrey A Sosman; Amit Verma; S Moss; Patricia Sorokin; Michael J Blend; Basil A Bradlow; N Chachlani; David Cutler; R Sabo; M Nelson; Edward Bruno; David M Gustin; Marlos Viana; Ronald Hoffman
Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: evidence for decreased platelet production.
British journal of haematology 2000;111(1):104-11.
2000: Mabel Koshy; Louise Dorn; Linda Bressler; Robert Molokie; Donald Lavelle; N Talischy; Ronald Hoffman; W van Overveld; Joseph DeSimone
2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia.
Blood 2000;96(7):2379-84.
2000: Koen van Besien; Amelia Bartholomew; Wendy Stock; David J Peace; Steven M Devine; Dorie A Sher; Jeffrey A Sosman; Yi-Hsiang Chen; Mabel Koshy; Ronald Hoffman
Fludarabine-based conditioning for allogeneic transplantation in adults with sickle cell disease.
Bone marrow transplantation 2000;26(4):445-9.
2000: E Rosler; J Brandt; JP Chute; Ronald Hoffman
Cocultivation of umbilical cord blood cells with endothelial cells leads to extensive amplification of competent CD34+CD38- cells.
Experimental hematology 2000;28(7):841-52.
2000: YM Alsayed; S Modi; Shahab Uddin; Nadim Mahmud; Brian J Druker; Eleanor N Fish; Ronald Hoffman; Leonidas C Platanias
All-trans-retinoic acid induces tyrosine phosphorylation of the CrkL adapter in acute promyelocytic leukemia cells.
Experimental hematology 2000;28(7):826-32.
1999: Leonidas C Platanias; Shahab Uddin; Edward Bruno; Mete Korkmaz; S Ahmad; YM Alsayed; DJ Van Den Berg; Brian J Druker; Amittha Wickrema; Ronald Hoffman
CrkL and CrkII participate in the generation of the growth inhibitory effects of interferons on primary hematopoietic progenitors.
Experimental hematology 1999;27(8):1315-21.
1999: Amittha Wickrema; F Chen; F Namin; T Yi; S Ahmad; Shahab Uddin; Yi-Hsiang Chen; Lawrence E Feldman; Wendy Stock; Ronald Hoffman; Leonidas C Platanias
Defective expression of the SHP-1 phosphatase in polycythemia vera.
Experimental hematology 1999;27(7):1124-32.
1999: JE Brandt; Amelia Bartholomew; Jeffrey D Fortman; MC Nelson; Edward Bruno; L M Chen; Julius Turian; T A Davis; JP Chute; Ronald Hoffman
Ex vivo expansion of autologous bone marrow CD34(+) cells with porcine microvascular endothelial cells results in a graft capable of rescuing lethally irradiated baboons.
Blood 1999;94(1):106-13.
1999: J A Medin; JE Brandt; E Rozler; M Nelson; Amelia Bartholomew; C Li; Julius Turian; JP Chute; T Chung; Ronald Hoffman
Ex vivo expansion and genetic marking of primitive human and baboon hematopoietic cells.
Annals of the New York Academy of Sciences 1999;872():233-40; discussion 240-2.
1998: DJ Van Den Berg; A K Sharma; Edward Bruno; Ronald Hoffman
Role of members of the Wnt gene family in human hematopoiesis.
Blood 1998;92(9):3189-202.
1998: JE Brandt; Anne Galy; KM Luens; MA Travis; J Young; J Tong; S Chen; T A Davis; K P Lee; B P Chen; R Tushinski; Ronald Hoffman
Bone marrow repopulation by human marrow stem cells after long-term expansion culture on a porcine endothelial cell line.
Experimental hematology 1998;26(10):950-61.
1998: Edward Bruno; Ronald Hoffman
Human megakaryocyte progenitor cells.
Seminars in hematology 1998;35(3):183-91.
1998: S Y Kim; stephen horrigan; J L Altenhofen; Zarema Arbieva; Ronald Hoffman; Carol A Westbrook
Modification of bacterial artificial chromosome clones using Cre recombinase: introduction of selectable markers for expression in eukaryotic cells.
Genome research 1998;8(4):404-12.
1998: Edward Bruno; stephen horrigan; DJ Van Den Berg; E Rozler; P R Fitting; S T Moss; Carol A Westbrook; Ronald Hoffman
The Smad5 gene is involved in the intracellular signaling pathways that mediate the inhibitory effects of transforming growth factor-beta on human hematopoiesis.
Blood 1998;91(6):1917-23.
1998: Lesley J Murray; KM Luens; M F Estrada; E Bruno; Ronald Hoffman; R L Cohen; M A Ashby; Saroj Vadhan-Raj
Thrombopoietin mobilizes CD34+ cell subsets into peripheral blood and expands multilineage progenitors in bone marrow of cancer patients with normal hematopoiesis.
Experimental hematology 1998;26(3):207-16.
1998: Ronald Hoffman; E Rozler; JP Chute; M Nelson; L Chen; Julius Turian; Amelia Bartholomew; JE Brandt
Ex vivo expansion of human hematopoietic stem cells: implications for the modern blood bank.
Vox sanguinis 1998;74 Suppl 2():259-64.
1996: B Hill; E Rozler; MA Travis; S Chen; A Zannetino; P Simmons; Anne Galy; B Chen; Ronald Hoffman
High-level expression of a novel epitope of CD59 identifies a subset of CD34+ bone marrow cells highly enriched for pluripotent stem cells.
Experimental hematology 1996;24(8):936-43.
1996: Ronald Hoffman; L J Murrav; JC Young; KM Luens; E Bruno
Hierarchical structure of human megakaryocyte progenitor cells.
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():75-81.