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Robert Hoffman

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Robert W Hoffman; Nikolaus Bezruczko; Kyle Perkins
An external validation study of a classification of mixed connective tissue disease and systemic lupus erythematosus patients.
Eric L Greidinger; Yunjuan Zang; Irina Fernandez; Mariana Berho; Mehdi Nassiri; Laisel Martinez; Robert W Hoffman
Tissue targeting of anti-RNP autoimmunity: effects of T cells and myeloid dendritic cells in a murine model.
Matthias Majetschak; Magdalena Perez; Luis T Sorell; Janet Lam; Marcos Maldonado; Robert W Hoffman
Circulating 20S proteasome levels in patients with mixed connective tissue disease and systemic lupus erythematosus.

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All Publications

2012: Robert W Hoffman; Nikolaus Bezruczko; Kyle Perkins
An external validation study of a classification of mixed connective tissue disease and systemic lupus erythematosus patients.
Journal of applied measurement 2012;13(2):205-16.
2009: Eric L Greidinger; Yunjuan Zang; Irina Fernandez; Mariana Berho; Mehdi Nassiri; Laisel Martinez; Robert W Hoffman
Tissue targeting of anti-RNP autoimmunity: effects of T cells and myeloid dendritic cells in a murine model.
Arthritis and rheumatism 2009;60(2):534-42.
2008: Matthias Majetschak; Magdalena Perez; Luis T Sorell; Janet Lam; Marcos Maldonado; Robert W Hoffman
Circulating 20S proteasome levels in patients with mixed connective tissue disease and systemic lupus erythematosus.
Clinical and vaccine immunology : CVI 2008;15(9):1489-93.
2008: Robert W Hoffman; Marcos Maldonado
Immune pathogenesis of Mixed Connective Tissue Disease: a short analytical review.
Clinical immunology (Orlando, Fla.) 2008;128(1):8-17.
2008: Eric L Greidinger; Yun Juan Zang; Kimberly Jaimes; Laisel Martinez; Mehdi Nassiri; Robert W Hoffman
CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):8444-54.
2008: Marcos Maldonado; Magdalena Perez; Judith Pignac-Kobinger; Emily Triana Marx; Elaine Tozman; Eric L Greidinger; Robert W Hoffman
Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a Midwestern US Caucasian population.
The Journal of rheumatology 2008;35(3):429-37.
2008: Kyle Perkins; Robert W Hoffman; Nikolaus Bezruczko
A Rasch analysis for classification of systemic lupus erythematosus and mixed connective tissue disease.
Journal of applied measurement 2008;9(2):136-50.
2007: Robert W Hoffman
T cells and the loss of immunologic tolerance in Sjögren's syndrome and systemic lupus erythematosus.
Arthritis and rheumatism 2007;56(10):3180-2.
2007: Alessandra C L Cervino; Nicholas F Tsinoremas; Robert W Hoffman
A genome-wide study of lupus: preliminary analysis and data release.
Annals of the New York Academy of Sciences 2007;1110():131-9.
2007: Eric L Greidinger; YunJuan Zang; Laisel Martinez; Kimberly Jaimes; Mehdi Nassiri; Pablo A Bejarano; Glen N Barber; Robert W Hoffman
Differential tissue targeting of autoimmunity manifestations by autoantigen-associated Y RNAs.
Arthritis and rheumatism 2007;56(5):1589-97.
2007: Michael P Keith; Chantal Moratz; Ryan Egan; Athina Zacharia; Eric L Greidinger; Robert W Hoffman; George C Tsokos
Anti-ribonucleoprotein antibodies mediate enhanced lung injury following mesenteric ischemia/reperfusion in Rag-1(-/-) mice.
Autoimmunity 2007;40(3):208-16.
2006: Eric L Greidinger; YunJuan Zang; Kimberly Jaimes; Scott Hogenmiller; Mehdi Nassiri; Pablo A Bejarano; Glen N Barber; Robert W Hoffman
A murine model of mixed connective tissue disease induced with U1 small nuclear RNP autoantigen.
Arthritis and rheumatism 2006;54(2):661-9.
2005: Eric L Greidinger; Robert W Hoffman
Autoantibodies in the pathogenesis of mixed connective tissue disease.
Rheumatic diseases clinics of North America 2005;31(3):437-50, vi.
2004: Robert W Hoffman
T cells in the pathogenesis of systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.) 2004;113(1):4-13.
2004: Robert W Hoffman; Tal Gazitt; Mark F Foecking; Robert A Ortmann; Michael L Misfeldt; Rebecca L Jorgenson; Steven L Young; Eric L Greidinger
U1 RNA induces innate immunity signaling.
Arthritis and rheumatism 2004;50(9):2891-6.
2004: Eric L Greidinger; Tal Gazitt; Kimberly Jaimes; Robert W Hoffman
Human T cell clones specific for heterogeneous nuclear ribonucleoprotein A2 autoantigen from connective tissue disease patients assist in autoantibody production.
Arthritis and rheumatism 2004;50(7):2216-22.
2004: Mihiri De Silva-Udawatta; Senthil R Kumar; Eric L Greidinger; Robert W Hoffman
Cloned human TCR from patients with autoimmune disease can respond to two structurally distinct autoantigens.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3940-7.
2004: Eric L Greidinger; Mark F Foecking; Joseph Magee; Linda Wilson; Sriya Ranatunga; Robert A Ortmann; Robert W Hoffman
A major B cell epitope present on the apoptotic but not the intact form of the U1-70-kDa ribonucleoprotein autoantigen.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):709-16.
2003: Robert W Hoffman; Eric L Greidinger
Epitope spreading in systemic lupus erythematosus: comment on the article by Monneaux and Muller.
Arthritis and rheumatism 2003;48(2):582-3.
2002: Eric L Greidinger; Mark F Foecking; Kim R Schäfermeyer; Craig W Bailey; Shannon L Primm; David R Lee; Robert W Hoffman
T cell immunity in connective tissue disease patients targets the RNA binding domain of the U1-70kDa small nuclear ribonucleoprotein.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3429-37.
2002: Eric L Greidinger; Mark F Foecking; Sriya Ranatunga; Robert W Hoffman
Apoptotic U1-70 kd is antigenically distinct from the intact form of the U1-70-kd molecule.
Arthritis and rheumatism 2002;46(5):1264-9.
2002: Yatish N Setty; Cory B Pittman; Adit S Mahale; Eric L Greidinger; Robert W Hoffman
Sicca symptoms and anti-SSA/Ro antibodies are common in mixed connective tissue disease.
The Journal of rheumatology 2002;29(3):487-9.
2002: Beth C Marshall; Richard A McPherson; Eric L Greidinger; Robert W Hoffman; Stuart P Adler
Lack of autoantibody production associated with cytomegalovirus infection.
Arthritis research 2002;4(5):R6.
2001: Robert W Hoffman
T cells in the pathogenesis of systemic lupus erythematosus.
Frontiers in bioscience : a journal and virtual library 2001;6():D1369-78.
2001: BL Talken; Craig W Bailey; S L Reardon; Charles Caldwell; Robert W Hoffman
Structural analysis of TCRalpha and beta chains from human T-Cell clones specific for small nuclear ribonucleoprotein polypeptides Sm-D, Sm-B and U1-70 kDa: TCR complementarity determining region 3 usage appears highly conserved.
Scandinavian journal of immunology 2001;54(1-2):204-10.
2001: BL Talken; Kim R Schäfermeyer; Craig W Bailey; David R Lee; Robert W Hoffman
T cell epitope mapping of the Smith antigen reveals that highly conserved Smith antigen motifs are the dominant target of T cell immunity in systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):562-8.
2001: M Chang; D B Lubahn; Robert W Hoffman
DNA microsatellite markers for estrogen receptor-beta are not associated with systemic lupus erythematosus.
The Journal of rheumatology 2001;28(4):924-5.
2001: Eric L Greidinger; Robert W Hoffman
The appearance of U1 RNP antibody specificities in sequential autoimmune human antisera follows a characteristic order that implicates the U1-70 kd and B'/B proteins as predominant U1 RNP immunogens.
Arthritis and rheumatism 2001;44(2):368-75.
2000: Robert W Hoffman; Eric L Greidinger
Mixed connective tissue disease.
Current opinion in rheumatology 2000;12(5):386-90.
2000: Eric L Greidinger; Livia Casciola-Rosen; S M Morris; Robert W Hoffman; Antony Rosen
Autoantibody recognition of distinctly modified forms of the U1-70-kd antigen is associated with different clinical disease manifestations.
Arthritis and rheumatism 2000;43(4):881-8.
2000: M Chang; Sara E Walker; Robert W Hoffman
Immunization with a bacterial ATP-binding cassette transporter fragment suppresses autoimmunity and prolongs survival in MRL/lpr lupus-prone mice.
Lupus 2000;9(9):655-63.
1999: M A Burdt; Robert W Hoffman; Susan L Deutscher; G S Wang; JC Johnson; GC Sharp
Long-term outcome in mixed connective tissue disease: longitudinal clinical and serologic findings.
Arthritis and rheumatism 1999;42(5):899-909.
1999: A L Zarling; J G Johnson; Robert W Hoffman; David R Lee
Induction of primary human CD8+ T lymphocyte responses in vitro using dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(9):5197-204.
1999: BL Talken; M M Holyst; David R Lee; Robert W Hoffman
T cell receptor beta-chain third complementarity-determining region gene usage is highly restricted among Sm-B autoantigen-specific human T cell clones derived from patients with connective tissue disease.
Arthritis and rheumatism 1999;42(4):703-9.
1999: BL Talken; David R Lee; Charles Caldwell; T P Quinn; Kim R Schäfermeyer; Robert W Hoffman
Analysis of T cell receptors specific for U1-70kD small nuclear ribonucleoprotein autoantigen: the alpha chain complementarity determining region three is highly conserved among connective tissue disease patients.
Human immunology 1999;60(3):200-8.
1999: GC Sharp; Robert W Hoffman
Clinical, immunologic, and immunogenetic evidence that mixed connective tissue disease is a distinct entity: comment on the article by Smolen and Steiner.
Arthritis and rheumatism 1999;42(1):190-1; author reply 193-6.
1998: BA Huyser; Jerry Parker; R Thoreson; Karen L Smarr; JC Johnson; Robert W Hoffman
Predictors of subjective fatigue among individuals with rheumatoid arthritis.
Arthritis and rheumatism 1998;41(12):2230-7.
1998: M Chang; R J Wang; D T Yangco; GC Sharp; Geetha R Komatireddy; Robert W Hoffman
Analysis of autoantibodies against RNA polymerases using immunoaffinity-purifed RNA polymerase I, II, and III antigen in an enzyme-linked immunosorbent assay.
Clinical immunology and immunopathology 1998;89(1):71-8.
1998: Stamatis-Nick C Liossis; Robert W Hoffman; George C Tsokos
Abnormal early TCR/CD3-mediated signaling events of a snRNP-autoreactive lupus T cell clone.
Clinical immunology and immunopathology 1998;88(3):305-10.
1997: Robert W McMurray; Robert W Hoffman; W Nelson; Sara E Walker
Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus--analyses of strain, gender, and age effects.
Clinical immunology and immunopathology 1997;84(3):260-8.
1997: M M Holyst; D L Hill; Sallie O Hoch; Robert W Hoffman
Analysis of human T cell and B cell responses against U small nuclear ribonucleoprotein 70-kd, B, and D polypeptides among patients with systemic lupus erythematosus and mixed connective tissue disease.
Arthritis and rheumatism 1997;40(8):1493-503.
1997: Robert W Hoffman; FX O'Sullivan; K R Schafermeyer; T L Moore; D Roussell; R Watson-McKown; MF Kim; Kim S Wise
Mycoplasma infection and rheumatoid arthritis: analysis of their relationship using immunoblotting and an ultrasensitive polymerase chain reaction detection method.
Arthritis and rheumatism 1997;40(7):1219-28.
1997: Karen L Smarr; Jerry Parker; GE Wright; RC Stucky-Ropp; SP Buckelew; Robert W Hoffman; FX O'Sullivan; John E Hewett
The importance of enhancing self-efficacy in rheumatoid arthritis.
Arthritis care and research : the official journal of the Arthritis Health Professions Association 1997;10(1):18-26.
1997: Geetha R Komatireddy; G S Wang; GC Sharp; Robert W Hoffman
Antiphospholipid antibodies among anti-U1-70 kDa autoantibody positive patients with mixed connective tissue disease.
The Journal of rheumatology 1997;24(2):319-22.
1996: Robert W McMurray; Robert W Hoffman; H Tang; Helen Braley-Mullen
T cell receptor V beta usage in murine experimental autoimmune thyroiditis.
Cellular immunology 1996;172(1):1-9.
1995: Robert W Hoffman; G C Sharp; Susan L Deutscher
Analysis of anti-U1 RNA antibodies in patients with connective tissue disease. Association with HLA and clinical manifestations of disease.
Arthritis and rheumatism 1995;38(12):1837-44.
1995: Robert W Hoffman; G C Sharp
Is anti-U1-RNP autoantibody positive connective tissue disease genetically distinct?
The Journal of rheumatology 1995;22(4):586-9.
1995: Sara E Walker; S H Allen; Robert W Hoffman; Robert W McMurray
Prolactin: a stimulator of disease activity in systemic lupus erythematosus.
Lupus 1995;4(1):3-9.
1994: M M Holyst; D L Hill; G C Sharp; Robert W Hoffman
Increased frequency of mutations in the hprt gene of T cells isolated from patients with anti-U1-70kD-autoantibody-positive connective tissue disease.
International archives of allergy and immunology 1994;105(3):234-7.
1994: A M Luger; G Komathireddy; R E Walker; Janardan P Pandey; Robert W Hoffman
Molecular and serologic analysis of HLA genes and immunoglobulin allotypes in IgA nephropathy.
Autoimmunity 1994;19(1):1-5.
1993: Robert W Hoffman; Y Takeda; G C Sharp; David R Lee; D L Hill; H Kaneoka; Charles Caldwell
Human T cell clones reactive against U-small nuclear ribonucleoprotein autoantigens from connective tissue disease patients and healthy individuals.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6460-9.
1993: Robert W Hoffman; JT Cassidy; Y Takeda; E I Smith-Jones; G S Wang; G C Sharp
U1-70-kd autoantibody-positive mixed connective tissue disease in children. A longitudinal clinical and serologic analysis.
Arthritis and rheumatism 1993;36(11):1599-602.
1992: Y Takeda; Kim S Wise; Robert W Hoffman
Nucleotide sequences of immunoglobulin heavy and light chain V-regions from a monoclonal autoantibody specific for a unique set of small nuclear ribonucleoprotein complexes.
Nucleic acids research 1992;20(15):4099.
1992: K C Hsu; D L Hill; Robert W Hoffman
HLA-DPB1*0401 is associated with the presence of autoantibodies reactive with the U1-70 kD polypeptide antigen of U1-small nuclear ribonucleoprotein among connective tissue disease patients.
Tissue antigens 1992;39(5):272-5.
1992: H Kaneoka; K C Hsu; Y Takeda; G C Sharp; Robert W Hoffman
Molecular genetic analysis of HLA-DR and HLA-DQ genes among anti-U1-70-kd autoantibody positive connective tissue disease patients.
Arthritis and rheumatism 1992;35(1):83-94.
1991: Robert W Hoffman; G C Sharp; W S Irvin; S K Anderson; John E Hewett; Janardan P Pandey
Association of immunoglobulin Km and Gm allotypes with specific antinuclear antibodies and disease susceptibility among connective tissue disease patients.
Arthritis and rheumatism 1991;34(4):453-8.
1991: H Kaneoka; David R Lee; K C Hsu; G C Sharp; Robert W Hoffman
Solid-phase direct DNA sequencing of allele-specific polymerase chain reaction-amplified HLA-DR genes.
BioTechniques 1991;10(1):30, 32, 34.
1990: Robert W Hoffman; L J Rettenmaier; Y Takeda; John E Hewett; I Pettersson; U Nyman; A M Luger; G C Sharp
Human autoantibodies against the 70-kd polypeptide of U1 small nuclear RNP are associated with HLA-DR4 among connective tissue disease patients.
Arthritis and rheumatism 1990;33(5):666-73.
1988: A L Braun; Robert W Hoffman
Clinical and genetic features of juvenile rheumatoid arthritis.
Missouri medicine 1988;85(12):799-803.
1988: Robert W Hoffman
Comment on the article by Myers et al. (HLA-D region epitopes associated with juvenile arthritis)
Arthritis and rheumatism 1988;31(4):575.
1986: Robert W Hoffman; S Shaw; L C Francis; M G Larson; R A Petersen; L T Chylack; David N Glass
HLA-DP antigens in patients with pauciarticular juvenile rheumatoid arthritis.
Arthritis and rheumatism 1986;29(9):1057-62.
1986: P Perez; Robert W Hoffman; J A Titus; D M Segal
Specific targeting of human peripheral blood T cells by heteroaggregates containing anti-T3 crosslinked to anti-target cell antibodies.
The Journal of experimental medicine 1986;163(1):166-78.
1985: Robert W Hoffman; R R Quinones; S Shaw
Anti-T3 antibody both activates and inhibits the cytotoxic activity of human T cell clones.
Behring Institute Mitteilungen 1985;(77):30-8.
1985: P Perez; Robert W Hoffman; S Shaw; J A Bluestone; D M Segal
Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody.
Nature 1985;316(6026):354-6.
1985: Robert W Hoffman; J A Bluestone; O Leo; S Shaw
Lysis of anti-T3-bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti-LFA-1 antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1985;135(1):5-8.
1984: Robert W Hoffman; M A Alspaugh; K S Waggie; J B Durham; S E Walker
Sjögren's syndrome in MRL/l and MRL/n mice.
Arthritis and rheumatism 1984;27(2):157-65.
1983: Robert W Hoffman; H K Yang; K S Waggie; J B Durham; J R Burge; S E Walker
Band keratopathy in MRL/l and MRL/n mice.
Arthritis and rheumatism 1983;26(5):645-52.
1982: Robert W Hoffman; S E Walker
HLA in human disease: what does it mean?
Missouri medicine 1982;79(6):346-9.