Timothy Hoffman

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Hoffman Timothy J; Smith Charles J
True radiotracers: Cu-64 targeting vectors based upon bombesin peptide.
Cantorias Melchor V; Figueroa Said D; Quinn Thomas P; Lever John R; Hoffman Timothy J; Watkinson Lisa D; Carmack Terry L; Cutler Cathy S
Development of high-specific-activity (68)Ga-labeled DOTA-rhenium-cyclized alpha-MSH peptide analog to target MC1 receptors overexpressed by melanoma tumors.
Prasanphanich Adam F; Retzloff Lauren; Lane Stephanie R; Nanda Prasant K; Sieckman Gary L; Rold Tammy L; Ma Lixin; Figueroa Said D; Sublett Samantha V; Hoffman Timothy J; Smith Charles J
In vitro and in vivo analysis of [(64)Cu-NO2A-8-Aoc-BBN(7-14)NH(2)]: a site-directed radiopharmaceutical for positron-emission tomography imaging of T-47D human breast cancer tumors.

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All Publications

2009: Hoffman Timothy J; Smith Charles J
True radiotracers: Cu-64 targeting vectors based upon bombesin peptide.
Nuclear medicine and biology 2009;36(6):579-85.
2009: Cantorias Melchor V; Figueroa Said D; Quinn Thomas P; Lever John R; Hoffman Timothy J; Watkinson Lisa D; Carmack Terry L; Cutler Cathy S
Development of high-specific-activity (68)Ga-labeled DOTA-rhenium-cyclized alpha-MSH peptide analog to target MC1 receptors overexpressed by melanoma tumors.
Nuclear medicine and biology 2009;36(5):505-13.
2009: Prasanphanich Adam F; Retzloff Lauren; Lane Stephanie R; Nanda Prasant K; Sieckman Gary L; Rold Tammy L; Ma Lixin; Figueroa Said D; Sublett Samantha V; Hoffman Timothy J; Smith Charles J
In vitro and in vivo analysis of [(64)Cu-NO2A-8-Aoc-BBN(7-14)NH(2)]: a site-directed radiopharmaceutical for positron-emission tomography imaging of T-47D human breast cancer tumors.
Nuclear medicine and biology 2009;36(2):171-81.
2009: Menegaz Rachel A; Sublett Samantha V; Figueroa Said D; Hoffman Timothy J; Ravosa Matthew J
Phenotypic plasticity and function of the hard palate in growing rabbits.
Anatomical record (Hoboken, N.J. : 2007) 2009;292(2):277-84.
2008: Abd-Elgaliel Wael R; Gallazzi Fabio; Garrison Jered C; Rold Tammy L; Sieckman Gary L; Figueroa Said Daibes; Hoffman Timothy J; Lever Susan Z
Design, synthesis, and biological evaluation of an antagonist-bombesin analogue as targeting vector.
Bioconjugate chemistry 2008;19(10):2040-8.
2008: Figueroa Said Daibes; Winkelmann Christopher T; Miller H William; Volkert Wynn A; Hoffman Timothy J
TLD assessment of mouse dosimetry during microCT imaging.
Medical physics 2008;35(9):3866-74.
2008: Garrison Jered C; Rold Tammy L; Sieckman Gary L; Naz Farah; Sublett Samantha V; Figueroa Said Daibes; Volkert Wynn A; Hoffman Timothy J
Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7-14)NH2 structural paradigm in a prostate cancer model.
Bioconjugate chemistry 2008;19(9):1803-12.
2008: Miao Yubin; Figueroa Said D; Fisher Darrell R; Moore Herbert A; Testa Richard F; Hoffman Timothy J; Quinn Thomas P
203Pb-labeled alpha-melanocyte-stimulating hormone peptide as an imaging probe for melanoma detection.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(5):823-9.
2008: Lane Stephanie R; Veerendra Bhadrasetty; Rold Tammy L; Sieckman Gary L; Hoffman Timothy J; Jurisson Silvia S; Smith Charles J
99mTc(CO)3-DTMA bombesin conjugates having high affinity for the GRP receptor.
Nuclear medicine and biology 2008;35(3):263-72.
2008: Jia Fang; Figueroa Said Daibes; Gallazzi Fabio; Balaji Baghavathy S; Hannink Mark; Lever Susan Z; Hoffman Timothy J; Lewis Michael R
Molecular imaging of bcl-2 expression in small lymphocytic lymphoma using 111In-labeled PNA-peptide conjugates.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(3):430-8.
2007: Kunstler Jens-Uwe; Veerendra Bhadrasetty; Figueroa Said D; Sieckman Gary L; Rold Tammy L; Hoffman Timothy J; Smith Charles J; Pietzsch Hans-Jurgen
Organometallic 99mTc(III) '4 + 1' bombesin(7-14) conjugates: synthesis, radiolabeling, and in vitro/in vivo studies.
Bioconjugate chemistry 2007;18(5):1651-61.
2007: Garrison Jered C; Rold Tammy L; Sieckman Gary L; Figueroa Said Daibes; Volkert Wynn A; Jurisson Silvia S; Hoffman Timothy J
In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(8):1327-37.
2007: Prasanphanich Adam F; Nanda Prasant K; Rold Tammy L; Ma Lixin; Lewis Michael R; Garrison Jered C; Hoffman Timothy J; Sieckman Gary L; Figueroa Said D; Smith Charles J
[64Cu-NOTA-8-Aoc-BBN(7-14)NH2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12462-7.
2007: Mohsin Huma; Fitzsimmons Jonathan; Shelton Tiffani; Hoffman Timothy J; Cutler Cathy S; Lewis Michael R; Athey Phillip S; Gulyas Gyongyi; Kiefer Garry E; Frank R Keith; Simon Jaime; Lever Susan Z; Jurisson Silvia S
Preparation and biological evaluation of 111In-, 177Lu- and 90Y-labeled DOTA analogues conjugated to B72.3.
Nuclear medicine and biology 2007;34(5):493-502.
2007: Ma Lixin; Yu Ping; Veerendra Bhadrasetty; Rold Tammy L; Retzloff Lauren; Prasanphanich Adam; Sieckman Gary; Hoffman Timothy J; Volkert Wynn A; Smith Charles J
In vitro and in vivo evaluation of Alexa Fluor 680-bombesin[7-14]NH2 peptide conjugate, a high-affinity fluorescent probe with high selectivity for the gastrin-releasing peptide receptor.
Molecular imaging : official journal of the Society for Molecular Imaging 2007;6(3):171-80.
2007: Prasanphanich Adam F; Lane Stephanie R; Figueroa Said D; Ma Lixin; Rold Tammy L; Sieckman Gary L; Hoffman Timothy J; McCrate Joseph M; Smith Charles J
The effects of linking substituents on the in vivo behavior of site-directed, peptide-based, diagnostic radiopharmaceuticals.
In vivo (Athens, Greece) 2007;21(1):1-16.
2006: Giblin Michael F; Sieckman Gary L; Watkinson Lisa D; Daibes-Figueroa Said; Hoffman Timothy J; Forte Leonard R; Volkert Wynn A
Selective targeting of E. coli heat-stable enterotoxin analogs to human colon cancer cells.
Anticancer research 2006;26(5A):3243-51.
2006: Alves Susana; Correia Joao D G; Santos Isabel; Veerendra Bhadrasetty; Sieckman Gary L; Hoffman Timothy J; Rold Tammy L; Figueroa Said Daibes; Retzloff Lauren; McCrate Joseph; Prasanphanich Adam; Smith Charles J
Pyrazolyl conjugates of bombesin: a new tridentate ligand framework for the stabilization of fac-[M(CO)3]+ moiety.
Nuclear medicine and biology 2006;33(5):625-34.
2006: Giblin Michael F; Gali Hariprasad; Sieckman Gary L; Owen Nellie K; Hoffman Timothy J; Volkert Wynn A; Forte Leonard R
In vitro and in vivo evaluation of 111In-labeled E. coli heat-stable enterotoxin analogs for specific targeting of human breast cancers.
Breast cancer research and treatment 2006;98(1):7-15.
2006: Giblin Michael F; Sieckman Gary L; Shelton Tiffani D; Hoffman Timothy J; Forte Leonard R; Volkert Wynn A
In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancers.
Nuclear medicine and biology 2006;33(4):481-8.
2006: Winkelmann Christopher T; Figueroa Said Daibes; Rold Tammy L; Volkert Wynn A; Hoffman Timothy J
Microimaging characterization of a B16-F10 melanoma metastasis mouse model.
Molecular imaging : official journal of the Society for Molecular Imaging 2006;5(2):105-14.
2006: Johnson Christopher V; Shelton Tiffani; Smith Charles J; Ma Lixin; Perry Michael C; Volkert Wynn A; Hoffman Timothy J
Evaluation of combined (177)Lu-DOTA-8-AOC-BBN (7-14)NH(2) GRP receptor-targeted radiotherapy and chemotherapy in PC-3 human prostate tumor cell xenografted SCID mice.
Cancer biotherapy & radiopharmaceuticals 2006;21(2):155-66.
2006: Mohsin Huma; Jia Fang; Sivaguru Geethapriya; Hudson Michael J; Shelton Tiffani D; Hoffman Timothy J; Cutler Cathy S; Ketring Alan R; Athey Phillip S; Simón Jaime; Frank R Keith; Jurisson Silvia S; Lewis Michael R
Radiolanthanide-labeled monoclonal antibody CC49 for radioimmunotherapy of cancer: biological comparison of DOTA conjugates and 149Pm, 166Ho, and 177Lu.
Bioconjugate chemistry 2006;17(2):485-92.
2006: Govindarajan Gurushankar; Hayden Melvin R; Cooper Shawna A; Figueroa Said Daibes; Ma Lixin; Hoffman Timothy J; Stump Craig S; Sowers James R
Metabolic derangements in the insulin-resistant heart.
Journal of the cardiometabolic syndrome 2006;1(2):102-6.
2005: Smith Charles J; Volkert Wynn A; Hoffman Timothy J
Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes.
Nuclear medicine and biology 2005;32(7):733-40.
2005: Miller William H; Hartmann-Siantar Christine; Fisher Darrell; Descalle Marie-Anne; Daly Tom; Lehmann Joerg; Lewis Michael R; Hoffman Timothy; Smith Jeff; Situ Peter D; Volkert Wynn A
Evaluation of beta-absorbed fractions in a mouse model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu radionuclides.
Cancer biotherapy & radiopharmaceuticals 2005;20(4):436-49.
2005: Miao Yubin; Hylarides Mark; Fisher Darrell R; Shelton Tiffani; Moore Herbert; Wester Dennis W; Fritzberg Alan R; Winkelmann Christopher T; Hoffman Timothy; Quinn Thomas P
Melanoma therapy via peptide-targeted {alpha}-radiation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5616-21.
2005: Miao Yubin; Hoffman Timothy J; Quinn Thomas P
Tumor-targeting properties of 90Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues in a murine melanoma model.
Nuclear medicine and biology 2005;32(5):485-93.
2005: Alves Susana; Paulo António; Correia João D G; Gano Lurdes; Smith Charles J; Hoffman Timothy J; Santos Isabel
Pyrazolyl derivatives as bifunctional chelators for labeling tumor-seeking peptides with the fac-[M(CO)3]+ moiety (M = 99mTc, Re): synthesis, characterization, and biological behavior.
Bioconjugate chemistry 2005;16(2):438-49.
2005: Miao Yubin; Owen Nellie K; Fisher Darrell R; Hoffman Timothy J; Quinn Thomas P
Therapeutic efficacy of a 188Re-labeled alpha-melanocyte-stimulating hormone peptide analog in murine and human melanoma-bearing mouse models.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(1):121-9.
2004: Giblin Michael F; Gali Hariprasad; Sieckman Gary L; Owen Nellie K; Hoffman Timothy J; Forte Leonard R; Volkert Wynn A
In vitro and in vivo comparison of human Escherichia coli heat-stable peptide analogues incorporating the 111In-DOTA group and distinct linker moieties.
Bioconjugate chemistry 2004;15(4):872-80.
2003: Smith C J; Volkert W A; Hoffman T J
Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: a concise update.
Nuclear medicine and biology 2003;30(8):861-8.
2003: Smith C Jeffrey; Sieckman Gary L; Owen Nellie K; Hayes Donald L; Mazuru Dana G; Kannan Raghuraman; Volkert Wynn A; Hoffman Timothy J
Radiochemical investigations of gastrin-releasing peptide receptor-specific [(99m)Tc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, tumor-bearing, rodent models: syntheses, radiolabeling, and in vitro/in vivo studies where Dpr = 2,3-diaminopropionic acid and X = H2O or P(CH2OH)3.
Cancer research 2003;63(14):4082-8.
2003: Kothari K K; Raghuraman K; Pillarsetty N K; Hoffman T J; Owen N K; Katti K V; Volkert W A
Syntheses, in vitro and in vivo characterization of a 99mTc-(I)-tricarbonyl-benzylamino-dihydroxymethyl phosphine (NP(2)) chelate.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2003;58(5):543-9.
2003: Hoffman Timothy J; Gali Hariprasad; Smith C Jeffrey; Sieckman Gary L; Hayes Donald L; Owen Nellie K; Volkert Wynn A
Novel series of 111In-labeled bombesin analogs as potential radiopharmaceuticals for specific targeting of gastrin-releasing peptide receptors expressed on human prostate cancer cells.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(5):823-31.
2003: Li Wen Ping; Smith C Jeff; Cutler Cathy S; Hoffman Timothy J; Ketring Alan R; Jurisson Silvia S
Aminocarboxylate complexes and octreotide complexes with no carrier added 177Lu, 166Ho and 149Pm.
Nuclear medicine and biology 2003;30(3):241-51.
2003: Pillarsetty Nagavarakishore; Katti Kavita K; Hoffman Timothy J; Volkert Wynn A; Katti Kattesh V; Kamei Hideo; Koide Tatsurou
In vitro and in vivo antitumor properties of tetrakis((trishydroxy- methyl)phosphine)gold(I) chloride.
Journal of medicinal chemistry 2003;46(7):1130-2.
2003: Smith C Jeffrey; Gali Hariprasad; Sieckman Gary L; Hayes Donald L; Owen Nellie K; Mazuru Dana G; Volkert Wynn A; Hoffman Timothy J
Radiochemical investigations of 177Lu-DOTA-8-Aoc-BBN[7-14]NH2: an in vitro/in vivo assessment of the targeting ability of this new radiopharmaceutical for PC-3 human prostate cancer cells.
Nuclear medicine and biology 2003;30(2):101-9.
2003: Smith C Jeffrey; Sieckman Gary L; Owen Nellie K; Hayes Donald L; Mazuru Dana G; Volkert Wynn A; Hoffman Timothy J
Radiochemical investigations of [188Re(H2O)(CO)3-diaminopropionic acid-SSS-bombesin(7-14)NH2]: syntheses, radiolabeling and in vitro/in vivo GRP receptor targeting studies.
Anticancer research 2003;23(1A):63-70.
2003: Smith C Jeffrey; Gali Hariprasad; Sieckman Gary L; Higginbotham Chris; Volkert Wynn A; Hoffman Timothy J
Radiochemical investigations of (99m)Tc-N(3)S-X-BBN[7-14]NH(2): an in vitro/in vivo structure-activity relationship study where X = 0-, 3-, 5-, 8-, and 11-carbon tethering moieties.
Bioconjugate chemistry 2003;14(1):93-102.
2002: Miao Yubin; Owen Nellie K; Whitener Donna; Gallazzi Fabio; Hoffman Timothy J; Quinn Thomas P
In vivo evaluation of 188Re-labeled alpha-melanocyte stimulating hormone peptide analogs for melanoma therapy.
International journal of cancer. Journal international du cancer 2002;101(5):480-7.
2002: Hu Fang; Cutler Cathy S; Hoffman Timothy; Sieckman Gary; Volkert Wynn A; Jurisson Silvia S
Pm-149 DOTA bombesin analogs for potential radiotherapy. in vivo comparison with Sm-153 and Lu-177 labeled DO3A-amide-betaAla-BBN(7-14)NH(2).
Nuclear medicine and biology 2002;29(4):423-30.
2002: Gali Hariprasad; Sieckman Gary L; Hoffman Timothy J; Owen Nellie K; Mazuru Dana G; Forte Leonard R; Volkert Wynn A
Chemical synthesis of Escherichia coli ST(h) analogues by regioselective disulfide bond formation: biological evaluation of an (111)In-DOTA-Phe(19)-ST(h) analogue for specific targeting of human colon cancers.
Bioconjugate chemistry 2002;13(2):224-31.
2002: Kothari K K; Gali H; Prabhu K R; Pillarsetty N; Owen N K; Katti K V; Hoffman T J; Volkert W A
Synthesis and characterization of (99m)Tc- and (188)Re-complexes with a diamido-dihydroxymethylenephosphine-based bifunctional chelating agent (N(2)P(2)-BFCA).
Nuclear medicine and biology 2002;29(1):83-9.
2001: Chen J; Cheng Z; Owen N K; Hoffman T J; Miao Y; Jurisson S S; Quinn T P
Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(12):1847-55.
2001: Gali H; Sieckman G L; Hoffman T J; Owen N K; Chin D T; Forte L R; Volkert W A
In vivo evaluation of an 111In-labeled ST-peptide analog for specific-targeting of human colon cancers.
Nuclear medicine and biology 2001;28(8):903-9.
2001: Gali H; Sieckman G L; Hoffman T J; Kiefer G E; Chin D T; Forte L R; Volkert W A
Synthesis and in vitro evaluation of an 111In-labeled ST-peptide enterotoxin (ST) analogue for specific targeting of guanylin receptors on human colonic cancers.
Anticancer research 2001;21(4A):2785-92.
2001: Hoffman T J; Quinn T P; Volkert W A
Radiometallated receptor-avid peptide conjugates for specific in vivo targeting of cancer cells.
Nuclear medicine and biology 2001;28(5):527-39.
2001: Gali H; Hoffman T J; Sieckman G L; Owen N K; Katti K V; Volkert W A
Synthesis, characterization, and labeling with 99mTc/188Re of peptide conjugates containing a dithia-bisphosphine chelating agent.
Bioconjugate chemistry 2001;12(3):354-63.
2001: Li W P; Ma D S; Higginbotham C; Hoffman T; Ketring A R; Cutler C S; Jurisson S S
Development of an in vitro model for assessing the in vivo stability of lanthanide chelates.
Nuclear medicine and biology 2001;28(2):145-54.
2000: Chen J; Cheng Z; Hoffman T J; Jurisson S S; Quinn T P
Melanoma-targeting properties of (99m)technetium-labeled cyclic alpha-melanocyte-stimulating hormone peptide analogues.
Cancer research 2000;60(20):5649-58.
1999: Karra S R; Schibli R; Gali H; Katti K V; Hoffman T J; Higginbotham C; Sieckman G L; Volkert W A
99mTc-labeling and in vivo studies of a bombesin analogue with a novel water-soluble dithiadiphosphine-based bifunctional chelating agent.
Bioconjugate chemistry 1999;10(2):254-60.
1998: Giblin M F; Wang N; Hoffman T J; Jurisson S S; Quinn T P
Design and characterization of alpha-melanotropin peptide analogs cyclized through rhenium and technetium metal coordination.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):12814-8.
1992: Roth C A; Hoffman T J; Corlija M; Volkert W A; Holmes R A
The effect of ligand structure on glutathione-mediated decomposition of propylene amine oxime derivatives.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1992;19(7):783-90.
1992: Corlija M; Katti K V; Volkert W A; Hoffman T J; Higginbotham C; Holmes R A
Formation of a stable 99mTc-tri-hydrazidophosphine oxide (99mTc-THP) chelate.
Journal of nuclear biology and medicine (Turin, Italy : 1991) 1992;36(3):296-300.
1992: Cleto E M; Holmes R A; Singh A; Bierman R; Islam S; Hoffman T J
Radiographic and neuro-SPECT imaging in an immature third ventricle teratoma: case report.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(3):435-7.
1992: Hoffman T J; Volkert W A; Corlija M; McKenzie E H; Chaplin S B; Oberle P A; Holmes R A
Evaluation of alkylated derivatives of 99mTc-propylene amine oxime (99mTc-PnAO).
Journal of nuclear biology and medicine (Turin, Italy : 1991) 1992;36(1):46-51.
1990: Volkert W A; Hoffman T J
Advances in radiopharmaceuticals for brain imaging with single-photon emission computed tomography.
Current opinion in radiology 1990;2(4):556-8.
1988: Hoffman T J; Corlija M; Chaplin S B; Volkert W A; Holmes R A
Retention of [99mTc]-d,l-HM-PAO in rat brain: an autoradiographic study.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1988;8(6):S38-43.
1988: Hoffman T J; Volkert W A; Holmes R A
Microcomputer-based digital image analysis system for quantitative autoradiography.
American journal of physiologic imaging 1988;3(2):81-90.
1986: Chaplin S B; Oberle P A; McKenzie E H; Hoffman T J; Volkert W A; Holmes R A; Canning L R; Pickett R D; Nowotnik D P; Neirinckx R D
Regional cerebral uptake and retention of 99mTc-tetramethyl- and pentamethyl-propyleneamine oxime chelates.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1986;13(3):261-7.
1985: Holmes R A; Chaplin S B; Royston K G; Hoffman T J; Volkert W A; Nowotnik D P; Canning L R; Cumming S A; Harrison R C; Higley B
Cerebral uptake and retention of 99Tcm-hexamethylpropyleneamine oxime (99Tcm-HM-PAO).
Nuclear medicine communications 1985;6(8):443-7.
1984: Seger R M; Hoffman T J; Holmes R A
Radionuclide evaluation of acute gastrointestinal bleeding. Case reports.
Missouri medicine 1984;81(6):308-11.
1984: Troutner D E; Volkert W A; Hoffman T J; Holmes R A
A neutral lipophilic complex of 99mTc with a multidentate amine oxime.
The International journal of applied radiation and isotopes 1984;35(6):467-70.
1984: Volkert W A; McKenzie E H; Hoffman T J; Troutner D E; Holmes R A
The behavior of neutral amine oxime chelates labelled with Tc at tracer level.
International journal of nuclear medicine and biology 1984;11(3-4):243-6.
1984: Ketring A R; Troutner D E; Hoffman T J; Stanton D K; Volkert W A; Holmes R A
Biodistribution of lipophilic 99mTc complexes of cyclam derivatives.
International journal of nuclear medicine and biology 1984;11(2):113-9.
1984: Volkert W A; Hoffman T J; Seger R M; Troutner D E; Holmes R A
99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical.
European journal of nuclear medicine 1984;9(11):511-6.

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