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Jean-Sébastien Hoffmann

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Valérie Bergoglio; Anne-Sophie Boyer; Christophe Cazaux; Kristin A Eckert; Marietta Y W T Lee; Gaëlle Legube; Valeria Naim; Laurie Rey; Filippo Rosselli; Erin Walsh; Jean-Sébastien Hoffmann
DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.
Bruno Luiz Fonseca Schamber-Reis; Sergio Schenkman; Santuza M R Teixeira; Maria Cristina Machado Motta; Sheila Nardelli; Sergio Danilo Junho Pena; Carlos Gustavo Régis-Silva; Priscila Carneiro Campos; Christophe Cazaux; Paula Gonçalves Cerqueira; Glória Regina Franco; Jean-Sébastien Hoffmann; Sabrina Almeida Lima; Andrea Mara Macedo; Carlos Renato Machado
DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions.
Fanny Lemée; Valérie Bergoglio; Anne Fernandez-Vidal; Alice Machado-Silva; Marie-Jeanne Pillaire; Anne Bieth; Catherine Gentil; Lee Baker; Anne-Laure Martin; Claire Leduc; Elena Lam; Eddy Magdeleine; Thomas Filleron; Naïma Oumouhou; Bernd Kaina; Mineaki Seki; Fanny Grimal; Magali Lacroix-Triki; Alastair Thompson; Henri Roché; Jean-Christophe Bourdon; Richard D Wood; Jean-Sébastien Hoffmann; Christophe Cazaux
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.

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All Publications

2013: Valérie Bergoglio; Anne-Sophie Boyer; Christophe Cazaux; Kristin A Eckert; Marietta Y W T Lee; Gaëlle Legube; Valeria Naim; Laurie Rey; Filippo Rosselli; Erin Walsh; Jean-Sébastien Hoffmann
DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.
The Journal of cell biology 2013;201(3):395-408.
2012: Bruno Luiz Fonseca Schamber-Reis; Sergio Schenkman; Santuza M R Teixeira; Maria Cristina Machado Motta; Sheila Nardelli; Sergio Danilo Junho Pena; Carlos Gustavo Régis-Silva; Priscila Carneiro Campos; Christophe Cazaux; Paula Gonçalves Cerqueira; Glória Regina Franco; Jean-Sébastien Hoffmann; Sabrina Almeida Lima; Andrea Mara Macedo; Carlos Renato Machado
DNA polymerase beta from Trypanosoma cruzi is involved in kinetoplast DNA replication and repair of oxidative lesions.
Molecular and biochemical parasitology 2012;183(2):122-31.
2010: Fanny Lemée; Valérie Bergoglio; Anne Fernandez-Vidal; Alice Machado-Silva; Marie-Jeanne Pillaire; Anne Bieth; Catherine Gentil; Lee Baker; Anne-Laure Martin; Claire Leduc; Elena Lam; Eddy Magdeleine; Thomas Filleron; Naïma Oumouhou; Bernd Kaina; Mineaki Seki; Fanny Grimal; Magali Lacroix-Triki; Alastair Thompson; Henri Roché; Jean-Christophe Bourdon; Richard D Wood; Jean-Sébastien Hoffmann; Christophe Cazaux
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(30):13390-5.
2010: Marie-Jeanne Pillaire; Janick Selves; K Gordien; Pierre-Antoine Gourraud; P-A Gouraud; C Gentil; M Danjoux; C Do; V Negre; Anne Bieth; Rosine Guimbaud; Didier Trouche; Philippe Pasero; M Méchali; Jean-Sébastien Hoffmann; Christophe Cazaux
A 'DNA replication' signature of progression and negative outcome in colorectal cancer.
Oncogene 2010;29(6):876-87.
2009: D O Lopes; F C Falconi; A M Goes; Y Canitrot; Jean-Sébastien Hoffmann; Christophe Cazaux; Glória Regina Franco; Andréa M Macedo; Sergio Pena; Conceição R S Machado
Isolation and characterization of HC1: a novel human DNA repair gene.
Genetics and molecular research : GMR 2009;8(1):247-60.
2007: F Lemée; Clarisse Bavoux; Marie-Jeanne Pillaire; Anne Bieth; Conceição R S Machado; Sergio Pena; Rosine Guimbaud; Janick Selves; Jean-Sébastien Hoffmann; Christophe Cazaux
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.
Oncogene 2007;26(23):3387-94.
2007: Muriel Golzio; L Mazzolini; A Ledoux; A Paganin; M Izard; L Hellaudais; Anne Bieth; Marie-Jeanne Pillaire; Christophe Cazaux; Jean-Sébastien Hoffmann; B Couderc; Justin Teissié
In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery.
Gene therapy 2007;14(9):752-9.
2007: Marie-Jeanne Pillaire; Rémy Betous; Chiara Conti; Jerzy Czaplicki; Philippe Pasero; Aaron Bensimon; Christophe Cazaux; Jean-Sébastien Hoffmann
Upregulation of error-prone DNA polymerases beta and kappa slows down fork progression without activating the replication checkpoint.
Cell cycle (Georgetown, Tex.) 2007;6(4):471-7.
2007: D O Lopes; Carlos Gustavo Regis-da-Silva; A Machado-Silva; Andréa M Macedo; Glória Regina Franco; Jean-Sébastien Hoffmann; Christophe Cazaux; Sergio Pena; Santuza M R Teixeira; Conceição R S Machado
Analysis of DNA polymerase activity in vitro using non-radioactive primer extension assay in an automated DNA sequencer.
Genetics and molecular research : GMR 2007;6(2):250-5.
2007: Jean-Pascal Capp; François Boudsocq; Anne-Gaelle Besnard; Bernard S Lopez; Christophe Cazaux; Jean-Sébastien Hoffmann; Yvan Canitrot
Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells.
Nucleic acids research 2007;35(11):3551-60.
2006: Carlos Gustavo Regis-da-Silva; Jorge M Freitas; Danielle Gomes Passos-Silva; Carolina Furtado; Luiz Augusto-Pinto; Márcio Tadeu Pereira; Wanderson D DaRocha; Glória Regina Franco; Andréa M Macedo; Jean-Sébastien Hoffmann; Christophe Cazaux; Sergio Pena; Santuza M R Teixeira; Conceição R S Machado
Characterization of the Trypanosoma cruzi Rad51 gene and its role in recombination events associated with the parasite resistance to ionizing radiation.
Molecular and biochemical parasitology 2006;149(2):191-200.
2006: Yvan Canitrot; Guy Laurent; Catherine Astarie-Dequeker; Christine Bordier; Christophe Cazaux; Jean-Sébastien Hoffmann
Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia.
Anticancer research 2006;26(1B):523-5.
2006: Jean-Pascal Capp; François Boudsocq; Pascale Bertrand; Audrey Laroche-Clary; Philippe Pourquier; Bernard S Lopez; Christophe Cazaux; Jean-Sébastien Hoffmann; Yvan Canitrot
The DNA polymerase lambda is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells.
Nucleic acids research 2006;34(10):2998-3007.
2005: Georges Massiot; Christophe Long; Bruno David; Marie-Jeanne Serrano; Florence Daubié; Frédéric Alby; Frédéric Ausseil; Martine Knibiehler; Christian Moretti; Jean-Sébastien Hoffmann; Christophe Cazaux; Catherine Lavaud
Acylphloroglucinol derivatives from Mahurea palustris.
Journal of natural products 2005;68(7):979-84.
2005: Clarisse Bavoux; Jean-Sébastien Hoffmann; Christophe Cazaux
Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa.
Biochimie 2005;87(7):637-46.
2005: François Boudsocq; P Benaim; Yvan Canitrot; Martine Knibiehler; Frédéric Ausseil; Jean-Pascal Capp; Anne Bieth; Christophe Long; Bruno David; I Shevelev; E Frierich-Heinecken; U Hübscher; F Amalric; Georges Massiot; Jean-Sébastien Hoffmann; Christophe Cazaux
Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta.
Molecular pharmacology 2005;67(5):1485-92.
2005: Clarisse Bavoux; Andreia Leopoldino; Valérie Bergoglio; Jiyang O-Wang; Tomoo Ogi; Anne Bieth; Jean-Gabriel Judde; Sergio Pena; Marie-France Poupon; Thomas Helleday; Masatoshi Tagawa; Carlosrenato Machado; Jean-Sébastien Hoffmann; Christophe Cazaux
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.
Cancer research 2005;65(1):325-30.
2004: Valérie Bergoglio; Mathilde Fréchet; Magali Philippe; Anne Bieth; Pascale Mercier; Dominique Morello; Magali Lacroix-Tricki; Georges Delsol; Jean-Sébastien Hoffmann; Christophe Cazaux
Evidence of finely tuned expression of DNA polymerase beta in vivo using transgenic mice.
FEBS letters 2004;566(1-3):147-50.
2004: Yvan Canitrot; Jean-Pascal Capp; Nadine Puget; Anne Bieth; Bernard Lopez; Jean-Sébastien Hoffmann; Christophe Cazaux
DNA polymerase beta overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells.
Nucleic acids research 2004;32(17):5104-12.
2003: Yvan Canitrot; Rafal Falinski; Thierry Louat; Guy Laurent; Christophe Cazaux; Jean-Sébastien Hoffmann; Dominique Lautier; Tomasz Skorski
p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation.
Blood 2003;102(7):2632-7.
2003: Valérie Bergoglio; Elena Ferrari; Ulrich Hübscher; Christophe Cazaux; Jean-Sébastien Hoffmann
DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA.
Journal of molecular biology 2003;331(5):1017-23.
2002: Laurence Servant; Christophe Cazaux; Anne Bieth; Shigenori Iwai; Fumio Hanaoka; Jean-Sébastien Hoffmann
A role for DNA polymerase beta in mutagenic UV lesion bypass.
The Journal of biological chemistry 2002;277(51):50046-53.
2002: Valérie Bergoglio; Clarisse Bavoux; Vincent Verbiest; Jean-Sébastien Hoffmann; Christophe Cazaux
Localisation of human DNA polymerase kappa to replication foci.
Journal of cell science 2002;115(Pt 23):4413-8.
2002: Valérie Bergoglio; Marie-Jeanne Pillaire; Magali Lacroix-Triki; Brigitte Raynaud-Messina; Yvan Canitrot; Anne Bieth; Michèle Garès; Michel Wright; Georges Delsol; Lawrence A Loeb; Christophe Cazaux; Jean-Sébastien Hoffmann
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
Cancer research 2002;62(12):3511-4.
2002: Mathilde Fréchet; Yvan Canitrot; Anne Bieth; Eugenia Dogliotti; Christophe Cazaux; Jean-Sébastien Hoffmann
Deregulated DNA polymerase beta strengthens ionizing radiation-induced nucleotidic and chromosomal instabilities.
Oncogene 2002;21(15):2320-7.
2002: Laurence Servant; Anne Bieth; Hiroshi Hayakawa; Christophe Cazaux; Jean-Sébastien Hoffmann
Involvement of DNA polymerase beta in DNA replication and mutagenic consequences.
Journal of molecular biology 2002;315(5):1039-47.
2001: Valérie Bergoglio; Yvan Canitrot; Linda A Hogarth; L Minto; S B Howell; Christophe Cazaux; Jean-Sébastien Hoffmann
Enhanced expression and activity of DNA polymerase beta in human ovarian tumor cells: impact on sensitivity towards antitumor agents.
Oncogene 2001;20(43):6181-7.
2001: Mathilde Fréchet; Yvan Canitrot; Christophe Cazaux; Jean-Sébastien Hoffmann
DNA polymerase beta imbalance increases apoptosis and mutagenesis induced by oxidative stress.
FEBS letters 2001;505(2):229-32.
2001: Thierry Louat; Laurence Servant; Marie-Pierre Rols; Anne Bieth; Justin Teissie; Jean-Sébastien Hoffmann; Christophe Cazaux
Antitumor activity of 2',3'-dideoxycytidine nucleotide analog against tumors up-regulating DNA polymerase beta.
Molecular pharmacology 2001;60(3):553-8.
2000: Yvan Canitrot; Jean-Sébastien Hoffmann; Patrick Calsou; H Hayakawa; bernard salles; Christophe Cazaux
Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: a potential source of genetic instability in cancer cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(12):1765-74.
2000: Nicolas Tanguy Le Gac; Jean-Sébastien Hoffmann; Robert Hindges; Giuseppe Villani
DNA synthesis by CHO cell extracts on fork-like DNA templates containing the major cisplatin adduct requires a ligation step.
Biochimie 2000;82(1):41-9.
1999: Yvan Canitrot; M Frechet; Laurence Servant; Christophe Cazaux; Jean-Sébastien Hoffmann
Overexpression of DNA polymerase beta: a genomic instability enhancer process.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(9):1107-11.
1999: Yvan Canitrot; Dominique Lautier; Guy Laurent; Mathilde Fréchet; A Ahmed; A G Turhan; bernard salles; Christophe Cazaux; Jean-Sébastien Hoffmann
Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta.
Oncogene 1999;18(17):2676-80.
1998: Yvan Canitrot; Christophe Cazaux; Mathilde Fréchet; K Bouayadi; Claire Lesca; bernard salles; Jean-Sébastien Hoffmann
Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12586-90.
1998: Jean-Sébastien Hoffmann; Christophe Cazaux
DNA synthesis, mismatch repair and cancer.
International journal of oncology 1998;12(2):377-82.
1997: Jean-Sébastien Hoffmann; D Locker; Giuseppe Villani; M Leng
HMG1 protein inhibits the translesion synthesis of the major DNA cisplatin adduct by cell extracts.
Journal of molecular biology 1997;270(4):539-43.
1997: K Bouayadi; Jean-Sébastien Hoffmann; Pierre Fons; M Tiraby; J P Reynes; Christophe Cazaux
Overexpression of DNA polymerase beta sensitizes mammalian cells to 2',3'-deoxycytidine and 3'-azido-3'-deoxythymidine.
Cancer research 1997;57(1):110-6.
1996: Jean-Sébastien Hoffmann; M J Pillaire; Claire Lesca; Dominique Burnouf; Robert Fuchs; Martine Defais; Giuseppe Villani
Fork-like DNA templates support bypass replication of lesions that block DNA synthesis on single-stranded templates.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):13766-9.
1996: N Tanguy Le Gac; Giuseppe Villani; Jean-Sébastien Hoffmann; Paul E Boehmer
The UL8 subunit of the herpes simplex virus type-1 DNA helicase-primase optimizes utilization of DNA templates covered by the homologous single-strand DNA-binding protein ICP8.
The Journal of biological chemistry 1996;271(35):21645-51.
1996: Jean-Sébastien Hoffmann; M J Pillaire; D Garcia-Estefania; S Lapalu; Giuseppe Villani
In vitro bypass replication of the cisplatin-d(GpG) lesion by calf thymus DNA polymerase beta and human immunodeficiency virus type I reverse transcriptase is highly mutagenic.
The Journal of biological chemistry 1996;271(26):15386-92.
1995: Jean-Sébastien Hoffmann; M J Pillaire; giovanni maga; V Podust; U Hübscher; Giuseppe Villani
DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5356-60.
1995: M J Pillaire; Jean-Sébastien Hoffmann; Martine Defais; Giuseppe Villani
Replication of DNA containing cisplatin lesions and its mutagenic consequences.
Biochimie 1995;77(10):803-7.
1992: M J Pillaire; Giuseppe Villani; Jean-Sébastien Hoffmann; A M Mazard; Martine Defais
Characterization and localization of cis-diamminedichloro-platinum(II) adducts on a purified oligonucleotide containing the codons 12 and 13 of H-ras proto-oncogene.
Nucleic acids research 1992;20(24):6473-9.
1992: Jean-Sébastien Hoffmann; E Moustacchi; Giuseppe Villani; E Sage
In vitro DNA synthesis by DNA polymerase I and DNA polymerase alpha on single-stranded DNA containing either purine or pyrimidine monoadducts.
Biochemical pharmacology 1992;44(6):1123-9.
1991: Jean-Sébastien Hoffmann; U Hübscher; B Michot; Giuseppe Villani
Interaction of cis-diamminedichloroplatinum (II) with single-stranded DNA in the presence or absence of Escherichia coli single-stranded binding protein.
Biochemical pharmacology 1991;42(7):1393-8.
1989: Jean-Sébastien Hoffmann; N P Johnson; Giuseppe Villani
Conversion of monofunctional DNA adducts of cis-diamminedichloroplatinum (II) to bifunctional lesions. Effect on the in vitro replication of single-stranded DNA by Escherichia coli DNA polymerase I and eukaryotic DNA polymerases alpha.
The Journal of biological chemistry 1989;264(25):15130-5.
1987: J P Vialaneix; Myriam Malet-Martino; Jean-Sébastien Hoffmann; J Pris; Robert Martino
Direct detection of new flucytosine metabolites in human biofluids by 19F nuclear magnetic resonance.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(5):718-24.