FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Torsten Hoffmann

Research Profile

Chemicals & Drugs

Concepts & Ideas

Procedures

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry

Living Beings

Genes & Molecular Sequences

Amino Acid Sequences

Co-author Network

Publications

TOP 3
Holger Cynis; Margreet R De Vries; Sabine Berg; Rico Eichentopf; Ernst-Joachim Freyse; Daniel Friedrich; Kathrin Gans; Sigrid Graubner; Monique Haegele; Ulrich Heiser; Isabel Hesse; Torsten Hoffmann; Wolfgang Jagla; Astrid Kehlen; Martin Kleinschmidt; Anke Müller; Paul H A Quax; Jens-Ulrich Rahfeld; Stephan Schilling; Reinhard Sedlmeier; Franziska Seifert; Anett Stephan; Daniela Trautwein; Michael Wermann; Raik Wolf; Ulrich Wollert; Hans-Ulrich Demuth
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Leona Wagner; Michael Wermann; Torsten Hoffmann; Jens-Ulrich Rahfeld; Fred Rosche; Hans-Ulrich Demuth
Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization.
Kerstin Kühn-Wache; Joachim W Bär; Torsten Hoffmann; Raik Wolf; Jens-Ulrich Rahfeld; Hans-Ulrich Demuth
Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Torsten Hoffmann (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2011: Holger Cynis; Margreet R De Vries; Sabine Berg; Rico Eichentopf; Ernst-Joachim Freyse; Daniel Friedrich; Kathrin Gans; Sigrid Graubner; Monique Haegele; Ulrich Heiser; Isabel Hesse; Torsten Hoffmann; Wolfgang Jagla; Astrid Kehlen; Martin Kleinschmidt; Anke Müller; Paul H A Quax; Jens-Ulrich Rahfeld; Stephan Schilling; Reinhard Sedlmeier; Franziska Seifert; Anett Stephan; Daniela Trautwein; Michael Wermann; Raik Wolf; Ulrich Wollert; Hans-Ulrich Demuth
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
EMBO molecular medicine 2011;3(9):545-58.
2011: Leona Wagner; Michael Wermann; Torsten Hoffmann; Jens-Ulrich Rahfeld; Fred Rosche; Hans-Ulrich Demuth
Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization.
Biological chemistry 2011;392(7):665-77.
2011: Kerstin Kühn-Wache; Joachim W Bär; Torsten Hoffmann; Raik Wolf; Jens-Ulrich Rahfeld; Hans-Ulrich Demuth
Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site.
Biological chemistry 2011;392(3):223-31.
2009: Nadine Frerker; Kerstin Raber; Felix Bode; Thomas Skripuletz; Heike Nave; Christian Klemann; Reinhard Pabst; Michael Stephan; Jutta Schade; Georg Brabant; Dirk Wedekind; Roland Jacobs; Anne Jörns; Ulf Forssmann; Rainer H Straub; Sigrid Johannes; Torsten Hoffmann; Leona Wagner; Hans-Ulrich Demuth; Stephan von Hörsten
Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, endocrine, and immune functions.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009;47(3):275-87.
2008: Stephan Schilling; Ulrike Zeitschel; Torsten Hoffmann; Ulrich Heiser; Mike Francke; Astrid Kehlen; Max Holzer; Birgit Hutter-Paier; Manuela Prokesch; Manfred Windisch; Wolfgang Jagla; Dagmar Schlenzig; Christiane Lindner; Thomas Rudolph; Gunter Reuter; Holger Cynis; Dirk Montag; Hans-Ulrich Demuth; Steffen Rossner
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
Nature medicine 2008;14(10):1106-11.
2008: Stephan Schilling; Thomas Appl; Torsten Hoffmann; Holger Cynis; Katrin Schulz; Wolfgang Jagla; Daniel Friedrich; Michael Wermann; Mirko Buchholz; Ulrich Heiser; Stephan von Hörsten; Hans-Ulrich Demuth
Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.
Journal of neurochemistry 2008;106(3):1225-36.
2008: Ulf Forssmann; Carsten Stoetzer; Michael Stephan; Carsten Kruschinski; Thomas Skripuletz; Jutta Schade; Andreas Schmiedl; Reinhard Pabst; Leona Wagner; Torsten Hoffmann; Astrid Kehlen; Sylvia E Escher; Wolf-Georg Forssmann; Jörn Elsner; Stephan von Hörsten
Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(2):1120-7.
2008: Carsten Kruschinski; Thomas Skripuletz; Sammy Bedoui; Kerstin Raber; Rainer H Straub; Torsten Hoffmann; Karsten Grote; Roland Jacobs; Michael Stephan; Reinhard Pabst; Stephan von Hörsten
Postnatal life events affect the severity of asthmatic airway inflammation in the adult rat.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(6):3919-25.
2008: Yue Xu; Yoshitaka Nakajima; Kiyoshi Ito; Heng Zheng; Hiroshi Oyama; Ulrich Heiser; Torsten Hoffmann; Ulf-Torsten Gärtner; Hans-Ulrich Demuth; Tadashi Yoshimoto
Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate-recognition mechanism.
Journal of molecular biology 2008;375(3):708-19.
2007: Daniel Friedrich; Torsten Hoffmann; Joachim Bär; Michael Wermann; Susanne Manhart; Ulrich Heiser; Hans-Ulrich Demuth
Does human attractin have DP4 activity?
Biological chemistry 2007;388(2):155-62.
2007: Nadine Frerker; Leona Wagner; Raik Wolf; Ulrich Heiser; Torsten Hoffmann; Jens-Ulrich Rahfeld; Jutta Schade; Tim Karl; Hassan Y Naim; Marwan Alfalah; Hans-Ulrich Demuth; Stephan von Hörsten
Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4.
Peptides 2007;28(2):257-68.
2006: Holger Cynis; Stephan Schilling; Mandy Bodnár; Torsten Hoffmann; Ulrich Heiser; Takaomi C Saido; Hans-Ulrich Demuth
Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.
Biochimica et biophysica acta 2006;1764(10):1618-25.
2006: Michael Engel; Torsten Hoffmann; Susanne Manhart; Ulrich Heiser; Sylvie CHAMBRE; Robert Huber; Hans-Ulrich Demuth; Wolfram Bode
Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.
Journal of molecular biology 2006;355(4):768-83.
2006: Leona Wagner; Torsten Hoffmann; Jens-Ulrich Rahfeld; Hans-Ulrich Demuth
Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR.
Advances in experimental medicine and biology 2006;575():109-16.
2005: Stephan Schilling; Holger Cynis; Alex von Bohlen; Torsten Hoffmann; Michael Wermann; Ulrich Heiser; Mirko Buchholz; Katrin Zunkel; Hans-Ulrich Demuth
Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.
Biochemistry 2005;44(40):13415-24.
2004: Jens Rüter; Torsten Hoffmann; Hans-Ulrich Demuth; Petra Moschansky; Burghard F Klapp; Martin Hildebrandt
Evidence for an interaction between leptin, T cell costimulatory antigens CD28, CTLA-4 and CD26 (dipeptidyl peptidase IV) in BCG-induced immune responses of leptin- and leptin receptor-deficient mice.
Biological chemistry 2004;385(6):537-41.
2004: Raik Wolf; Torsten Hoffmann; Fred Rosche; Hans-Ulrich Demuth
Simultaneous determination of incretin hormones and their truncated forms from human plasma by immunoprecipitation and liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;803(1):91-9.
2004: Stephan Schilling; Torsten Hoffmann; Susanne Manhart; Matthias Hoffmann; Hans-Ulrich Demuth
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.
FEBS letters 2004;563(1-3):191-6.
2003: Stephan Schilling; André J Niestroj; Jens-Ulrich Rahfeld; Torsten Hoffmann; Michael Wermann; Katrin Zunkel; Claus Wasternack; Hans-Ulrich Demuth
Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators.
The Journal of biological chemistry 2003;278(50):49773-9.
2003: Stephan Schilling; Susanne Manhart; Torsten Hoffmann; Hans-Henning Ludwig; Claus Wasternack; Hans-Ulrich Demuth
Substrate specificity of glutaminyl cyclases from plants and animals.
Biological chemistry 2003;384(12):1583-92.
2003: Joachim Bär; Anja Weber; Torsten Hoffmann; Jörg Stork; Michael Wermann; Leona Wagner; Susanne Aust; Bernd Gerhartz; Hans-Ulrich Demuth
Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme.
Biological chemistry 2003;384(12):1553-63.
2003: Tim Karl; Torsten Hoffmann; Reinhard Pabst; Stephan von Hörsten
Extreme reduction of dipeptidyl peptidase IV activity in F344 rat substrains is associated with various behavioral differences.
Physiology & behavior 2003;80(1):123-34.
2003: Tim Karl; Wojciech T Chwalisz; Dirk Wedekind; Hans J Hedrich; Torsten Hoffmann; Roland Jacobs; Reinhard Pabst; Stephan von Hörsten
Localization, transmission, spontaneous mutations, and variation of function of the Dpp4 (Dipeptidyl-peptidase IV; CD26) gene in rats.
Regulatory peptides 2003;115(2):81-90.
2003: Tim Karl; Torsten Hoffmann; Reinhard Pabst; Stephan von Hörsten
Behavioral effects of neuropeptide Y in F344 rat substrains with a reduced dipeptidyl-peptidase IV activity.
Pharmacology, biochemistry, and behavior 2003;75(4):869-79.
2003: Michael Engel; Torsten Hoffmann; Leona Wagner; Michael Wermann; Ulrich Heiser; Reiner Kiefersauer; Robert Huber; Wolfram Bode; Hans-Ulrich Demuth; Hans Brandstetter
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5063-8.
2003: André J Niestroj; Dagmar Schlenzig; Ulrich Heiser; Kerstin Kühn-Wache; Blas Cigic; Michael Werman; Torsten Hoffmann; Bernd Gerhartz; Hans-Ulrich Demuth
Acylated hydroxamates as selective and highly potent inhibitors of dipeptidyl peptidase I.
Advances in experimental medicine and biology 2003;524():339-43.
2003: Jens Rüter; Hans-Ulrich Demuth; Petra C Arck; Torsten Hoffmann; Burghard F Klapp; Martin Hildebrandt
Inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity modulates surface expression of CTLA-4 in stress-induced abortions.
Advances in experimental medicine and biology 2003;524():155-63.
2003: Joerg Stork; Torsten Hoffmann; Hans-Ulrich Demuth
Investigation of DP IV-dependent protein-protein interactions using surface plasmon resonance.
Advances in experimental medicine and biology 2003;524():115-9.
2003: Daniel Friedrich; Kerstin Kühn-Wache; Torsten Hoffmann; Hans-Ulrich Demuth
Isolation and characterization of attractin-2.
Advances in experimental medicine and biology 2003;524():109-13.
2003: Joachim W Baer; Bernd Gerhartz; Torsten Hoffmann; Fred Rosche; Hans-Ulrich Demuth
Characterisation of human DP IV produced by a Pichia pastoris expression system.
Advances in experimental medicine and biology 2003;524():103-8.
2003: Kerstin Kühn-Wache; Torsten Hoffmann; Susanne Manhart; W Brandt; Hans-Ulrich Demuth
The specificity of DP IV for natural substrates is peptide structure determined.
Advances in experimental medicine and biology 2003;524():57-63.
2002: Jens Rüter; Torsten Hoffmann; Ulrich Heiser; Hans-Ulrich Demuth; Petra C Arck; Burghard F Klapp; Martin Hildebrandt
The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions.
Cellular immunology 2002;220(2):150-6.
2002: Stephan Schilling; Torsten Hoffmann; Fred Rosche; Susanne Manhart; Claus Wasternack; Hans-Ulrich Demuth
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity.
Biochemistry 2002;41(35):10849-57.
2002: Simon Hinke; Christopher H S McIntosh; Torsten Hoffmann; Kerstin Kühn-Wache; Leona Wagner; Joachim Bär; Susanne Manhart; Michael Wermann; Raymond A Pederson; Hans-Ulrich Demuth
On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors.
Diabetes care 2002;25(8):1490-1; author reply 1491-2.
2002: Stephan Schilling; Torsten Hoffmann; Michael Wermann; Ulrich Heiser; Claus Wasternack; Hans-Ulrich Demuth
Continuous spectrometric assays for glutaminyl cyclase activity.
Analytical biochemistry 2002;303(1):49-56.
2002: Simon Hinke; Kerstin Kühn-Wache; Torsten Hoffmann; Raymond A Pederson; Christopher H S McIntosh; Hans-Ulrich Demuth
Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.
Biochemical and biophysical research communications 2002;291(5):1302-8.
2001: R Wolf; Fred Rosche; Torsten Hoffmann; Hans-Ulrich Demuth
Immunoprecipitation and liquid chromatographic-mass spectrometric determination of the peptide glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 from human plasma samples. New sensitive method to analyze physiological concentrations of peptide hormones.
Journal of chromatography. A 2001;926(1):21-7.
2001: J Andrew Pospisilik; Simon Hinke; Raymond A Pederson; Torsten Hoffmann; Fred Rosche; Dagmar Schlenzig; K Glund; Ulrich Heiser; Christopher H S McIntosh; Hans-Ulrich Demuth
Metabolism of glucagon by dipeptidyl peptidase IV (CD26).
Regulatory peptides 2001;96(3):133-41.
2000: Simon Hinke; J Andrew Pospisilik; Hans-Ulrich Demuth; S Mannhart; Kerstin Kühn-Wache; Torsten Hoffmann; E Nishimura; Raymond A Pederson; Christopher H S McIntosh
Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs.
The Journal of biological chemistry 2000;275(6):3827-34.
2000: Fred Rosche; J Schmidt; Torsten Hoffmann; RP Pauly; Christopher H S McIntosh; Raymond A Pederson; Hans-Ulrich Demuth
Kinetic analysis of enzymatic and nonenzymatic degradation of peptides by MALDI-TOFMS.
Methods in molecular biology (Clifton, N.J.) 2000;146():251-72.
2000: Kerstin Kühn-Wache; Susanne Manhart; Torsten Hoffmann; Simon Hinke; Rick Gelling; Raymond A Pederson; Christopher H S McIntosh; Hans-Ulrich Demuth
Analogs of glucose-dependent insulinotropic polypeptide with increased dipeptidyl peptidase IV resistance.
Advances in experimental medicine and biology 2000;477():187-95.