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Johan Hoffstedt

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Peter Arner; Johan Hoffstedt; Erik Näslund; Anders Thorell; Anders Thörne; Mikael Wirén; Daniel Peter Andersson; Mikael Rydén
Variations in the size of the major omentum are primarily determined by fat cell number.
D P Andersson; Peter Arner; Patrik Löfgren; A Thorell; Johan Hoffstedt
Visceral fat cell lipolysis and cardiovascular risk factors in obesity.
Hong Jiao; Juha Kere; Oluf Pedersen; Ferdinand van't Hooft; Thorkild I A Sørensen; Peter Arner; Tomas Axelsson; David Brodin; Karine Clement; Sébastien Czernichow; Karin Dahlman-Wright; Beatrice Dubern; Anders Hamsten; Torben Hansen; Johannes Hebebrand; Johan Hoffstedt; Ingrid Dahlman
Genome wide association study identifies KCNMA1 contributing to human obesity.

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All Publications

2013: Peter Arner; Johan Hoffstedt; Erik Näslund; Anders Thorell; Anders Thörne; Mikael Wirén; Daniel Peter Andersson; Mikael Rydén
Variations in the size of the major omentum are primarily determined by fat cell number.
The Journal of clinical endocrinology and metabolism 2013;98(5):E897-901.
2011: D P Andersson; Peter Arner; Patrik Löfgren; A Thorell; Johan Hoffstedt
Visceral fat cell lipolysis and cardiovascular risk factors in obesity.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2011;43(11):809-15.
2011: Hong Jiao; Juha Kere; Oluf Pedersen; Ferdinand van't Hooft; Thorkild I A Sørensen; Peter Arner; Tomas Axelsson; David Brodin; Karine Clement; Sébastien Czernichow; Karin Dahlman-Wright; Beatrice Dubern; Anders Hamsten; Torben Hansen; Johannes Hebebrand; Johan Hoffstedt; Ingrid Dahlman
Genome wide association study identifies KCNMA1 contributing to human obesity.
BMC medical genomics 2011;4():51.
2010: Johan Hoffstedt; E Arner; H Wahrenberg; D P Andersson; V Qvisth; P Löfgren; Mikael Rydén; A Thörne; M Wirén; M Palmér; A Thorell; E Toft; Peter Arner
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity.
Diabetologia 2010;53(12):2496-503.
2010: Anders Thörne; Patrik Löfgren; Johan Hoffstedt
Increased visceral adipocyte lipolysis--a pathogenic role in nonalcoholic fatty liver disease?
The Journal of clinical endocrinology and metabolism 2010;95(10):E209-13.
2009: Margareta Jernås; Bob Olsson; Peter Arner; Peter Jacobson; Lars Sjöström; Andrew Walley; philippe froguel; Philip G McTernan; Johan Hoffstedt; Lena Carlsson
Regulation of carboxylesterase 1 (CES1) in human adipose tissue.
Biochemical and biophysical research communications 2009;383(1):63-7.
2009: Andrea Dicker; Gaby Aström; K Wåhlén; Johan Hoffstedt; Erik Näslund; Mikael Wirén; Mikael Rydén; Peter Arner; Vanessa van Harmelen
Primary differences in lipolysis between human omental and subcutaneous adipose tissue observed using in vitro differentiated adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2009;41(5):350-5.
2009: Martin Neovius; Sophia M Rossner; Karin Vågstrand; Yvonne Linné von Hausswolff-Juhlin; Johan Hoffstedt; Ulf Ekelund
Adiposity measures as indicators of metabolic risk factors in adolescents.
Obesity facts 2009;2(5):294-301.
2008: Kirsty L Spalding; Erik Arner; Pål O Westermark; Samuel Bernard; Bruce Buchholz; Olaf Bergmann; Lennart Blomqvist; Johan Hoffstedt; Erik Näslund; Tom Britton; Hernan Concha; Moustapha Hassan; Mikael Rydén; Jonas Frisén; Peter Arner
Dynamics of fat cell turnover in humans.
Nature 2008;453(7196):783-7.
2008: Peter Arner; Britta M Stenson; Elisabeth Dungner; Erik Näslund; Johan Hoffstedt; Mikael Ryden; Ingrid Dahlman
Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance.
The Journal of clinical endocrinology and metabolism 2008;93(6):2249-54.
2008: Kerstin Wåhlén; Eva Sjölin; Johan Hoffstedt
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis.
Journal of lipid research 2008;49(3):607-11.
2008: Salim Mottagui-Tabar; Johan Hoffstedt; Anthony J Brookes; Hong Jiao; Peter Arner; Ingrid Dahlman
Association of ADRB1 and UCP3 gene polymorphisms with insulin sensitivity but not obesity.
Hormone research 2008;69(1):31-6.
2007: Johan Hoffstedt; D Förster; Patrik Löfgren
Impaired subcutaneous adipocyte lipogenesis is associated with systemic insulin resistance and increased apolipoprotein B/AI ratio in men and women.
Journal of internal medicine 2007;262(1):131-9.
2007: Thorhallur Agustsson; Mikael Rydén; Johan Hoffstedt; Vanessa van Harmelen; Andrea Dicker; Jurga Laurencikiene; Bengt Isaksson; Johan Permert; Peter Arner
Mechanism of increased lipolysis in cancer cachexia.
Cancer research 2007;67(11):5531-7.
2007: Ingrid Dahlman; Andrea Dicker; Hong Jiao; Juha Kere; Lennart Blomqvist; Vanessa van Harmelen; Johan Hoffstedt; Knut Borch-Johnsen; Torben Jorgensen; Torben Hansen; Oluf Pedersen; Markku Laakso; Peter Arner
A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis.
American journal of human genetics 2007;80(6):1115-24.
2007: Mikael Rydén; Johan W E Jocken; Vanessa van Harmelen; Andrea Dicker; Johan Hoffstedt; Mikael Wirén; Lennart Blomqvist; Aline Mairal; Dominique Langin; Ellen E Blaak; Peter Arner
Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1847-55.
2007: Patrik Löfgren; Eva Sjölin; Kerstin Wåhlen; Johan Hoffstedt
Human adipose tissue cannabinoid receptor 1 gene expression is not related to fat cell function or adiponectin level.
The Journal of clinical endocrinology and metabolism 2007;92(4):1555-9.
2007: Vanessa van Harmelen; Mikael Rydén; Eva Sjölin; Johan Hoffstedt
A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression.
Journal of lipid research 2007;48(1):201-6.
2006: Ingrid Dahlman; Maria Nilsson; Hong Jiao; Johan Hoffstedt; Cecilia M Lindgren; Keith Humphreys; Juha Kere; Jan-�ke GUSTAFSSON; Peter Arner; Karin Dahlman-Wright
Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity.
Pharmacogenetics and genomics 2006;16(12):881-9.
2006: Jose L Santos; Philippe Boutin; Camilla Verdich; Claus Holst; Lesli H Larsen; Søren Toubro; Christian Dina; Wim H M Saris; Ellen E Blaak; Johan Hoffstedt; Moira A Taylor; Jan Polak; Karine Clement; Dominique Langin; Arne Astrup; philippe froguel; Oluf Pedersen; Thorkild I A Sorensen; J Alfredo Martinez
Genotype-by-nutrient interactions assessed in European obese women. A case-only study.
European journal of nutrition 2006;45(8):454-62.
2006: Emma Carlsson; Lovisa E Johansson; K Ström; Johan Hoffstedt; Leif Groop; Cecilia Holm; Martin Ridderstråle
The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects.
International journal of obesity (2005) 2006;30(9):1442-8.
2006: Aline Mairal; Dominique Langin; Peter Arner; Johan Hoffstedt
Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity.
Diabetologia 2006;49(7):1629-36.
2006: Lovisa E Johansson; Johan Hoffstedt; Hemang Parikh; Emma Carlsson; Martin Wabitsch; Anne-Greth Bondeson; Jan Hedenbro; Hans Tornqvist; Leif Groop; Martin Ridderstråle
Variation in the adiponutrin gene influences its expression and associates with obesity.
Diabetes 2006;55(3):826-33.
2006: Catharina Lavebratt; Asude Alpman; B Persson; Peter Arner; Johan Hoffstedt
Common neuropeptide Y2 receptor gene variant is protective against obesity among Swedish men.
International journal of obesity (2005) 2006;30(3):453-9.
2005: Patrik Löfgren; Ingalena Andersson; Hans Wahrenberg; Johan Hoffstedt
No difference in lipolysis or glucose transport of subcutaneous fat cells between moderate-fat and low-fat hypocaloric diets in obese women.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(12):734-40.
2005: Catharina Lavebratt; Selim Sengul; H F Gu; B Persson; Louise Nordfors; Claes-Göran Ostenson; Suad Efendic; Peter Arner; Johan Hoffstedt; Martin Schalling
Association study between chromosome 10q26.11 and obesity among Swedish men.
International journal of obesity (2005) 2005;29(12):1422-8.
2005: Dominique Langin; Andrea Dicker; Geneviève Tavernier; Johan Hoffstedt; Aline Mairal; Mikael Rydén; Erik Arner; Audrey Sicard; Christopher M Jenkins; Nathalie Viguerie; Vanessa van Harmelen; Richard W Gross; Cecilia Holm; Peter Arner
Adipocyte lipases and defect of lipolysis in human obesity.
Diabetes 2005;54(11):3190-7.
2005: Patrik Löfgren; Johan Hoffstedt; Erik Näslund; Mikael Wirén; Peter Arner
Prospective and controlled studies of the actions of insulin and catecholamine in fat cells of obese women following weight reduction.
Diabetologia 2005;48(11):2334-42.
2005: Patrik Löfgren; Ingalena Andersson; Birgitta Adolfsson; Britt-Marie Leijonhufvud; Katarina Hertel; Johan Hoffstedt; Peter Arner
Long-term prospective and controlled studies demonstrate adipose tissue hypercellularity and relative leptin deficiency in the postobese state.
The Journal of clinical endocrinology and metabolism 2005;90(11):6207-13.
2005: Catharina Lavebratt; Elisabeth Dungner; Johan Hoffstedt
Polymorphism of the AHSG gene is associated with increased adipocyte beta2-adrenoceptor function.
Journal of lipid research 2005;46(10):2278-81.
2005: Shane McCarthy; Salim Mottagui-Tabar; Yumi Mizuno; Bengt Sennblad; Johan Hoffstedt; Peter Arner; Claes Wahlestedt; Björn Andersson
Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin.
Human genetics 2005;117(6):545-57.
2005: Johan Hoffstedt; Mikael Rydén; Hans Wahrenberg; Vanessa van Harmelen; Peter Arner
Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis.
The Journal of clinical endocrinology and metabolism 2005;90(9):5356-60.
2005: Catharina Lavebratt; Sofia Wahlqvist; Louise Nordfors; Johan Hoffstedt; Peter Arner
AHSG gene variant is associated with leanness among Swedish men.
Human genetics 2005;117(1):54-60.
2005: Y Linné; Ingrid Dahlman; Johan Hoffstedt
beta1-Adrenoceptor gene polymorphism predicts long-term changes in body weight.
International journal of obesity (2005) 2005;29(5):458-62.
2005: Nathalie Viguerie; Hubert Vidal; Peter Arner; Claus Holst; Camilla Verdich; Sebastien Avizou; Arne Astrup; Wim H M Saris; I A Macdonald; Eva Klimcakova; Karine Clément; A Martinez; Johan Hoffstedt; Thorkild I A Sørensen; Dominique Langin
Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets.
Diabetologia 2005;48(1):123-31.
2004: Emma Carlsson; Peter Almgren; Johan Hoffstedt; Leif Groop; Martin Ridderstråle
The FOXC2 C-512T polymorphism is associated with obesity and dyslipidemia.
Obesity research 2004;12(11):1738-43.
2004: Johan Hoffstedt; Elisabet Arvidsson; Eva Sjölin; Kerstin Wåhlén; Peter Arner
Adipose tissue adiponectin production and adiponectin serum concentration in human obesity and insulin resistance.
The Journal of clinical endocrinology and metabolism 2004;89(3):1391-6.
2004: P Eriksson; Ingrid Dahlman; Mikael Rydén; Johan Hoffstedt; P Arner
Relationship between beta-2 adrenoceptor gene haplotypes and adipocyte lipolysis in women.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(2):185-90.
2003: Salim Mottagui-Tabar; Mikael Rydén; Patrik Löfgren; Gary Faulds; Johan Hoffstedt; A J Brookes; Ingalena Andersson; Peter Arner
Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis.
Diabetologia 2003;46(6):789-97.
2003: Anastasia Iliadou; Paul Lichtenstein; Susanne Ahlberg; Johan Hoffstedt; Peter Arner; Martin Schalling; Nancy L Pedersen; Catharina Lavebratt
No linkage to obesity in candidate regions of chromosome 2 and 10 in a selected sample of Swedish twins.
Twin research : the official journal of the International Society for Twin Studies 2003;6(2):162-9.
2002: Catharina Lavebratt; Mikael Rydén; Martin Schalling; Selim Sengul; Susanne Ahlberg; Johan Hoffstedt
The hormone-sensitive lipase i6 gene polymorphism and body fat accumulation.
European journal of clinical investigation 2002;32(12):938-42.
2002: J Uddén; P Eriksson; Johan Hoffstedt
Glucocorticoid-regulated adipose tissue secretion of PAI-1, but not IL-6, TNFalpha or leptin in vivo.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(11-12):698-702.
2002: Rachel M Fisher; Johan Hoffstedt; G S Hotamisligil; Anders Thörne; Mikael Rydén
Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2002;26(10):1379-85.
2002: Johan Hoffstedt; P Eriksson; Salim Mottagui-Tabar; Peter Arner
A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(7):355-9.
2002: Johan Hoffstedt; Erik Näslund; Peter Arner
Calpain-10 gene polymorphism is associated with reduced beta(3)-adrenoceptor function in human fat cells.
The Journal of clinical endocrinology and metabolism 2002;87(7):3362-7.
2002: Hans Wahrenberg; Anders Wennlund; Johan Hoffstedt
Increased adipose tissue secretion of interleukin-6, but not of leptin, plasminogen activator inhibitor-1 or tumour necrosis factor alpha, in Graves' hyperthyroidism.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(5):607-11.
2002: Mikael Rydén; Gary Faulds; Johan Hoffstedt; Anders Wennlund; Peter Arner
Effect of the (C825T) Gbeta(3) polymorphism on adrenoceptor-mediated lipolysis in human fat cells.
Diabetes 2002;51(5):1601-8.
2002: Johan Hoffstedt; I-L Andersson; L Persson; Bengt Isaksson; Peter Arner
The common -675 4G/5G polymorphism in the plasminogen activator inhibitor -1 gene is strongly associated with obesity.
Diabetologia 2002;45(4):584-7.
2002: Johan Hoffstedt; Mikael Rydén; Patrik Löfgren; M Orho-Melander; L Groop; Peter Arner
Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells.
Diabetologia 2002;45(2):276-82.
2002: Patrik Löfgren; Johan Hoffstedt; Mikael Rydén; Anders Thörne; Cecilia Holm; Hans Wahrenberg; Peter Arner
Major gender differences in the lipolytic capacity of abdominal subcutaneous fat cells in obesity observed before and after long-term weight reduction.
The Journal of clinical endocrinology and metabolism 2002;87(2):764-71.
2002: Ingvar Ek; Peter Arner; Mikael Rydén; Cecilia Holm; Anders Thörne; Johan Hoffstedt; Hans Wahrenberg
A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance.
Diabetes 2002;51(2):484-92.
2001: J Uddén; R Folkesson; Johan Hoffstedt
Downregulation of uncoupling protein 2 mRNA in women treated with glucocorticoids.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(11):1615-8.
2001: Mikael Rydén; Johan Hoffstedt; P Eriksson; S Bringman; Peter Arner
The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(11):1599-603.
2001: Rachel M Fisher; Per Eriksson; Johan Hoffstedt; G S Hotamisligil; Anders Thörne; Mikael Rydén; Anders Hamsten; Peter Arner
Fatty acid binding protein expression in different adipose tissue depots from lean and obese individuals.
Diabetologia 2001;44(10):1268-73.
2001: Johan Hoffstedt; Peter Arner; Martin Schalling; Nancy L Pedersen; Selim Sengul; Susanne Ahlberg; Anastasia Iliadou; Catharina Lavebratt
A common hormone-sensitive lipase i6 gene polymorphism is associated with decreased human adipocyte lipolytic function.
Diabetes 2001;50(10):2410-3.
2001: Johan Hoffstedt; Anastasia Iliadou; Nancy L Pedersen; Martin Schalling; Peter Arner
The effect of the beta(2) adrenoceptor gene Thr164Ile polymorphism on human adipose tissue lipolytic function.
British journal of pharmacology 2001;133(5):708-12.
2001: Mikael Rydén; M Elizalde; Vanessa van Harmelen; A Ohlund; Johan Hoffstedt; S Bringman; K Andersson
Increased expression of eNOS protein in omental versus subcutaneous adipose tissue in obese human subjects.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(6):811-5.
2001: T Skoog; P Eriksson; Johan Hoffstedt; Mikael Rydén; A Hamsten; P Armer
Tumour necrosis factor-alpha (TNF-alpha) polymorphisms-857C/A and -863C/A are associated with TNF-alpha secretion from human adipose tissue.
Diabetologia 2001;44(5):654-5.
2000: Johan Hoffstedt; R Folkesson; Hans Wahrenberg; Anders Wennlund; Vanessa van Harmelen; Peter Arner
A marked upregulation of uncoupling protein 2 gene expression in adipose tissue of hyperthyroid subjects.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2000;32(11-12):475-9.
2000: Vanessa van Harmelen; Parisa Ariapart; Johan Hoffstedt; Inger Lundkvist; S Bringman; Peter Arner
Increased adipose angiotensinogen gene expression in human obesity.
Obesity research 2000;8(4):337-41.
2000: Vanessa van Harmelen; M Elizalde; Parisa Ariapart; S Bergstedt-Lindqvist; S Reynisdottir; Johan Hoffstedt; Inger Lundkvist; S Bringman; Peter Arner
The association of human adipose angiotensinogen gene expression with abdominal fat distribution in obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(6):673-8.
2000: Per Eriksson; Vanessa van Harmelen; Johan Hoffstedt; P Lundquist; Hubert Vidal; V Stemme; Anders Hamsten; Peter Arner; S Reynisdottir
Regional variation in plasminogen activator inhibitor-1 expression in adipose tissue from obese individuals.
Thrombosis and haemostasis 2000;83(4):545-8.
2000: Johan Hoffstedt; P Eriksson; L Hellström; S Rössner; Mikael Rydén; Peter Arner
Excessive fat accumulation is associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men.
Diabetologia 2000;43(1):117-20.
1999: Vanessa van Harmelen; S Reynisdottir; K Cianflone; E Degerman; Johan Hoffstedt; K Nilsell; A Sniderman; Peter Arner
Mechanisms involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin.
The Journal of biological chemistry 1999;274(26):18243-51.
1999: Johan Hoffstedt; Odette Poirier; Anders Thörne; Fredrik Lönnqvist; Stefan-Martin Herrmann; F Cambien; Peter Arner
Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function.
Diabetes 1999;48(1):203-5.
1998: Louise Nordfors; Johan Hoffstedt; B Nyberg; Anders Thörne; Peter Arner; Martin Schalling; Fredrik Lönnqvist
Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects.
Diabetologia 1998;41(8):935-9.
1998: Vanessa van Harmelen; S Reynisdottir; Per Eriksson; Anders Thörne; Johan Hoffstedt; Fredrik Lönnqvist; Peter Arner
Leptin secretion from subcutaneous and visceral adipose tissue in women.
Diabetes 1998;47(6):913-7.
1997: Johan Hoffstedt; Peter Arner; G Hellers; Fredrik Lönnqvist
Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men.
Journal of lipid research 1997;38(4):795-804.
1996: Johan Hoffstedt; Hans Wahrenberg; Anders Thörne; Fredrik Lönnqvist
The metabolic syndrome is related to beta 3-adrenoceptor sensitivity in visceral adipose tissue.
Diabetologia 1996;39(7):838-44.
1996: Johan Hoffstedt; Fredrik Lönnqvist; M Shimizu; E Blaak; Peter Arner
Effects of several putative beta 3-adrenoceptor agonists on lipolysis in human omental adipocytes.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(5):428-34.
1996: Johan Hoffstedt; S Reynisdottir; Fredrik Lönnqvist
Systolic blood pressure is related to catecholamine sensitivity in subcutaneous abdominal fat cells.
Obesity research 1996;4(1):21-6.
1995: Johan Hoffstedt; M Shimizu; S Sjöstedt; Fredrik Lönnqvist
Determination of beta 3-adrenoceptor mediated lipolysis in human fat cells.
Obesity research 1995;3(5):447-57.
1995: Fredrik Lönnqvist; A Thöme; K Nilsell; Johan Hoffstedt; Peter Arner
A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.
The Journal of clinical investigation 1995;95(3):1109-16.