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Marten Hofker
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57
Havekes, Louis
36
Frants, Rune
27
Willems van Dijk, Ko
20
de Winther, Menno
17
Gijbels, Marion
16
van Vlijmen, Bart
14
Wijmenga, Cisca
12
van Der Zee, Anneke
10
van Ommen, Gert-Jan
10
Dahlmans, Vivian
10
Padberg, George
9
van Eck, Miranda
8
van Gorp, Patrick
8
van der Boom, H
8
van Vliet-Ostaptchouk, Jana
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All Publications
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2009: Meex Steven J R; Weissglas-Volkov Daphna; van der Kallen Carla J H; Thuerauf Donna J; van Greevenbroek Marleen M J; Schalkwijk Casper G; Stehouwer Coen D A; Feskens Edith J M; Heldens Lonneke; Ayoubi Torik A; Hofker Marten H; Wouters Bradly G; Vlietinck Robert; Sinsheimer Janet S; Taskinen Marja-Riitta; Kuusisto Johanna; Laakso Markku; de Bruin Tjerk W A; Pajukanta Päivi; Glembotski Christopher C
The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1322-7.
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2009: Reiling Erwin; van Vliet-Ostaptchouk Jana V; van 't Riet Esther; van Haeften Timon W; Arp Pascal A; Hansen Torben; Kremer Dennis; Groenewoud Marlous J; van Hove Els C; Romijn Johannes A; Smit Jan W A; Nijpels Giel; Heine Robert J; Uitterlinden André G; Pedersen Oluf; Slagboom P Eline; Maassen Johannes A; Hofker Marten H; 't Hart Leen M; Dekker Jacqueline M
Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.
European journal of human genetics : EJHG 2009;17(8):1056-62.
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2008: Vanschoonbeek Kristof; Wouters Kristiaan; van der Meijden Paola E J; van Gorp Patrick J; Feijge Marion A H; Herfs Marjolein; Schurgers Leon J; Hofker Marten H; de Maat Moniek P M; Heemskerk Johan W M
Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(11):2023-9.
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2008: Xanthoulea Sofia; Gijbels Marion J J; van der Made Ingeborg; Mujcic Hilda; Thelen Melanie; Vergouwe Monique N; Ambagts Matheus H C; Hofker Marten H; de Winther Menno P J
P55 tumour necrosis factor receptor in bone marrow-derived cells promotes atherosclerosis development in low-density lipoprotein receptor knock-out mice.
Cardiovascular research 2008;80(2):309-18.
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2008: Rensen Sander S; Niessen Petra M; van Deursen Jan M; Janssen Ben J; Heijman Edwin; Hermeling Evelien; Meens Merlijn; Lie Natascha; Gijbels Marion J; Strijkers Gustav J; Doevendans Pieter A; Hofker Marten H; De Mey Jo G R; van Eys Guillaume J
Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice.
Circulation 2008;118(8):828-36.
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2008: Wouters Kristiaan; van Gorp Patrick J; Bieghs Veerle; Gijbels Marion J; Duimel Hans; Lütjohann Dieter; Kerksiek Anja; van Kruchten Roger; Maeda Nobuyo; Staels Bart; van Bilsen Marc; Shiri-Sverdlov Ronit; Hofker Marten H
Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.) 2008;48(2):474-86.
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2008: Curfs Daniëlle M J; Ghesquiere Stijn A I; Vergouwe Monique N; van der Made Ingeborg; Gijbels Marion J J; Greaves David R; Verbeek J Sjef; Hofker Marten H; de Winther Menno P J
Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology.
The Journal of biological chemistry 2008;283(31):21640-8.
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2008: Meex Steven J R; van Vliet-Ostaptchouk Jana V; van der Kallen Carla J H; van Greevenbroek Marleen M J; Schalkwijk Casper G; Feskens Edith J M; Blaak Ellen E; Wijmenga Cisca; Hofker Marten H; Stehouwer Coen D A; de Bruin Tjerk W A
Upstream transcription factor 1 (USF1) in risk of type 2 diabetes: association study in 2000 Dutch Caucasians.
Molecular genetics and metabolism 2008;94(3):352-5.
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2008: Groeneweg Mathijs; Vergouwe Monique N; Scheffer Peter G; Vermue Hendrikus P A; Sollewijn Gelpke Maarten D; Sijbers Anneke M; Leitinger Norbert; Hofker Marten H; de Winther Menno P J
Modification of LDL with oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) results in a novel form of minimally modified LDL that modulates gene expression in macrophages.
Biochimica et biophysica acta 2008;1781(6-7):336-43.
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2008: van Vliet-Ostaptchouk Jana V; Onland-Moret N Charlotte; van Haeften Timon W; Franke Lude; Elbers Clara C; Shiri-Sverdlov Ronit; van der Schouw Yvonne T; Hofker Marten H; Wijmenga Cisca
HHEX gene polymorphisms are associated with type 2 diabetes in the Dutch Breda cohort.
European journal of human genetics : EJHG 2008;16(5):652-6.
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2008: Hofker Marten; Bernini Franco; von Eckardstein Arnold; Freeman Dilys; Heeren Joerg; Karpe Fredrik; Kalopissis Athina; Kronenberg Florian; Kuipers Folkert; Lindstedt Ken; Parini Paolo; Schuster Gertrud; van Dijk Ko Willems
European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007.
Atherosclerosis 2008;197(1):471-9.
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2008: Snieder H; Wang X; Shiri-Sverdlov R; van Vliet-Ostaptchouk J V; Hofker M H; Perks U; Spector T D; O'Dell S D
TUB is a candidate gene for late-onset obesity in women.
Diabetologia 2008;51(1):54-61.
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2008: van Vliet-Ostaptchouk Jana V; Onland-Moret N Charlotte; Shiri-Sverdlov Ronit; van Gorp Patrick J J; Custers Anne; Peeters Petra H M; Wijmenga Cisca; Hofker Marten H; van der Schouw Yvonne T
Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women.
PloS one 2008;3(1):e1405.
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2007: Moen Corina J A; Tholens Aart P; Voshol Peter J; de Haan Willeke; Havekes Louis M; Gargalovic Peter; Lusis Aldons J; van Dyk Ko Willems; Frants Rune R; Hofker Marten H; Rensen Patrick C N
The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides.
Journal of lipid research 2007;48(10):2182-92.
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2007: Hofker Marten; Calabresi Laura; von Eckardstein Arnold; Heeren Joerg; Karpe Fredrik; Kalopissis Athina; Kronenberg Florian; Kuipers Folkert; Lindstedt Ken; Parini Paolo; Schuster Gertrud; van Dijk Ko Willems
European Lipoprotein Club: Report of the 29th ELC Annual Conference, Tutzing, 4-7 September 2006.
Atherosclerosis 2007;193(2):461-8.
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2007: Ricketts Marie-Louise; Boekschoten Mark V; Kreeft Arja J; Hooiveld Guido J E J; Moen Corina J A; Müller Michael; Frants Rune R; Kasanmoentalib Soemini; Post Sabine M; Princen Hans M G; Porter J Gordon; Katan Martijn B; Hofker Marten H; Moore David D
The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors.
Molecular endocrinology (Baltimore, Md.) 2007;21(7):1603-16.
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2007: Meex Steven J R; van Greevenbroek Marleen M J; Ayoubi Torik A; Vlietinck Robert; van Vliet-Ostaptchouk Jana V; Hofker Martin H; Vermeulen Vicky M M-J; Schalkwijk Casper G; Feskens Edith J M; Boer Jolanda M A; Stehouwer Coen D A; van der Kallen Carla J H; de Bruin Tjerk W A
Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians.
The Journal of clinical endocrinology and metabolism 2007;92(7):2720-5.
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2007: van Beek Esther A; Bakker Arjen H; Kruyt Philip M; Hofker Marten H; Saris Wim H; Keijer Jaap
Intra- and interindividual variation in gene expression in human adipose tissue.
Pflügers Archiv : European journal of physiology 2007;453(6):851-61.
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2007: van Vliet-Ostaptchouk J V; Shiri-Sverdlov R; Zhernakova A; Strengman E; van Haeften T W; Hofker M H; Wijmenga C
Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.
Diabetologia 2007;50(1):59-62.
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2006: Groeneweg Mathijs; Kanters Edwin; Vergouwe Monique N; Duerink Hilde; Kraal Georg; Hofker Marten H; de Winther Menno P J
Lipopolysaccharide-induced gene expression in murine macrophages is enhanced by prior exposure to oxLDL.
Journal of lipid research 2006;47(10):2259-67.
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2006: Shiri-Sverdlov Ronit; Wouters Kristiaan; van Gorp Patrick J; Gijbels Marion J; Noel Benoit; Buffat Laurent; Staels Bart; Maeda Nobuyo; van Bilsen Marc; Hofker Marten H
Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates.
Journal of hepatology 2006;44(4):732-41.
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2006: Shiri-Sverdlov Ronit; Custers Anne; van Vliet-Ostaptchouk Jana V; van Gorp Patrick J J; Lindsey Patrick J; van Tilburg Jonathan H O; Zhernakova Sasha; Feskens Edith J M; van der A Daphne L; Dollé Martijn E T; van Haeften Timon W; Koeleman Bobby P C; Hofker Marten H; Wijmenga Cisca
Identification of TUB as a novel candidate gene influencing body weight in humans.
Diabetes 2006;55(2):385-9.
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2005: Niessen Petra; Rensen Sander; van Deursen Jan; De Man Joris; De Laet Ann; Vanderwinden Jean-Marie; Wedel Thilo; Baker Darren; Doevendans Pieter; Hofker Marten; Gijbels Marion; van Eys Guillaume
Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice.
Gastroenterology 2005;129(5):1592-601.
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2005: Kreeft Arja J; Moen Corina J A; Porter Gordon; Kasanmoentalib Soemini; Sverdlov Ronit; van Gorp Patrick J; Havekes Louis M; Frants Rune R; Hofker Marten H
Genomic analysis of the response of mouse models to high-fat feeding shows a major role of nuclear receptors in the simultaneous regulation of lipid and inflammatory genes.
Atherosclerosis 2005;182(2):249-57.
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2005: Xanthoulea Sofia; Curfs Danielle M J; Hofker Marten H; de Winther Menno P J
Nuclear factor kappa B signaling in macrophage function and atherogenesis.
Current opinion in lipidology 2005;16(5):536-42.
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2005: de Winther Menno P J; Kanters Edwin; Kraal Georg; Hofker Marten H
Nuclear factor kappaB signaling in atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(5):904-14.
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2005: Ghesquiere Stijn A I; Gijbels Marion J J; Anthonsen Marit; van Gorp Patrick J J; van der Made Ingeborg; Johansen Berit; Hofker Marten H; de Winther Menno P J
Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition.
Journal of lipid research 2005;46(2):201-10.
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2005: Ghesquiere Stijn A I; Hofker Marten H; de Winther Menno P J
The role of phospholipases in lipid modification and atherosclerosis.
Cardiovascular toxicology 2005;5(2):161-82.
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2005: Wouters Kristiaan; Shiri-Sverdlov Ronit; van Gorp Patrick J; van Bilsen Marc; Hofker Marten H
Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2005;43(5):470-9.
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2004: Hofker Marten
Lipoxygenases at the heart of atherosclerosis susceptibility.
European journal of human genetics : EJHG 2004;12(8):601-2.
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2004: Hofker M; Calabresi L; Jauhiainen M; Nimpf J; Rudling M; Talmud P; Mooser V; Dallinga-Thie G; von Eckardstein A; Staels B; Karpe F; Kuipers F
European Lipoprotein Club: report of the 26th ELC Annual Conference, Tutzing, 8-11 September 2003.
Atherosclerosis 2004;173(1):125-34.
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2004: Kanters Edwin; Gijbels Marion J J; van der Made Ingeborg; Vergouwe Monique N; Heeringa Peter; Kraal Georg; Hofker Marten H; de Winther Menno P J
Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype.
Blood 2004;103(3):934-40.
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2003: Kanters Edwin; Pasparakis Manolis; Gijbels Marion J J; Vergouwe Monique N; Partouns-Hendriks Iris; Fijneman Remond J A; Clausen Björn E; Förster Irmgard; Kockx Mark M; Rajewsky Klaus; Kraal Georg; Hofker Marten H; de Winther Menno P J
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.
The Journal of clinical investigation 2003;112(8):1176-85.
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2003: Cullen Paul; Baetta Roberta; Bellosta Stefano; Bernini Franco; Chinetti Giulia; Cignarella Andrea; von Eckardstein Arnold; Exley Andrew; Goddard Martin; Hofker Marten; Hurt-Camejo Eva; Kanters Edwin; Kovanen Petri; Lorkowski Stefan; McPheat William; Pentikäinen Markku; Rauterberg Jürgen; Ritchie Andrew; Staels Bart; Weitkamp Benedikt; de Winther Menno;
Rupture of the atherosclerotic plaque: does a good animal model exist?
Arteriosclerosis, thrombosis, and vascular biology 2003;23(4):535-42.
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2003: Bowyer David; Dallinga-Thie Geesje; von Eckardstein Arnold; Hofker Marten; Jauhiainen Matti; Mooser Vincent; Nimpf Johannes; Rudling Matts; Staels Bart; Talmud Philippa
European lipoprotein club: report of the 25th ELC annual conference. Tutzing, 9-12 September 2002.
Atherosclerosis 2003;167(1):159-68.
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2003: Hofker Marten H
Introduction: the use of transgenic mice in biomedical research.
Methods in molecular biology (Clifton, N.J.) 2003;209():1-8.
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2002: Dallinga-Thie G; Bowyer David; Dallinga-Thie Geesge; Dieplinger Hans; Funke Harald; Hofker Marten; Jauhiainen Matti; Nimpf Johannes; Staels Bart; Talmud Philippa; Tarugi Patricia
European Lipoprotein Club: Report of the 24th ELC Annual Conference, Tutzing, 10-13 September 2001.
Atherosclerosis 2002;162(2):439-47.
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2002: Tacken Paul J; Delsing Dianne J M; Gijbels Marion J J; Quax Paul H A; Havekes Louis M; Hofker Marten H; van Dijk Ko Willems
VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area.
Atherosclerosis 2002;162(1):103-10.
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2002: de Winther Menno P J; Hofker Marten H
New mouse models for lipoprotein metabolism and atherosclerosis.
Current opinion in lipidology 2002;13(2):191-7.
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2001: Kreeft A J; Moen C J; Hofker M H; Frants R R; Vreugdenhil E; Gijbels M J; Havekes L M; Datson N A
Identification of differentially regulated genes in mildly hyperlipidemic ApoE3-Leiden mice by use of serial analysis of gene expression.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):1984-90.
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2001: Tacken P J; van der Zee A; Beumer T L; Florijn R J; Gijpels M J; Havekes L M; Frants R R; van Dijk K W; Hofker M H
Effective generation of very low density lipoprotein receptor transgenic mice by overlapping genomic DNA fragments: high testis expression and disturbed spermatogenesis.
Transgenic research 2001;10(3):211-21.
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2001: Tacken P J; Hofker M H; Havekes L M; van Dijk K W
Living up to a name: the role of the VLDL receptor in lipid metabolism.
Current opinion in lipidology 2001;12(3):275-9.
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2001: Van Eck M; Van Dijk K W; Herijgers N; Hofker M H; Groot P H; Van Berkel T J
Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis.
Atherosclerosis 2001;154(1):103-12.
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2000: Van Eck M; De Winther M P; Herijgers N; Havekes L M; Hofker M H; Groot P H; Van Berkel T J
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(12):2600-6.
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2000: Tacken P J; Teusink B; Jong M C; Harats D; Havekes L M; van Dijk K W; Hofker M H
LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice.
Journal of lipid research 2000;41(12):2055-62.
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2000: Herijgers N; de Winther M P; Van Eck M; Havekes L M; Hofker M H; Hoogerbrugge P M; Van Berkel T J
Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice.
Journal of lipid research 2000;41(9):1402-9.
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2000: Mensenkamp A R; van Luyn M J; van Goor H; Bloks V; Apostel F; Greeve J; Hofker M H; Jong M C; van Vlijmen B J; Havekes L M; Kuipers F
Hepatic lipid accumulation, altered very low density lipoprotein formation and apolipoprotein E deposition in apolipoprotein E3-Leiden transgenic mice.
Journal of hepatology 2000;33(2):189-98.
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2000: de Beer F; van Dijk K W; Jong M C; van Vark L C; van der Zee A; Hofker M H; Fallaux F J; Hoeben R C; Smelt A H; Havekes L M
Apolipoprotein E2 (Lys146-->Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(7):1800-6.
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2000: de Winther M P; Hofker M H
Scavenging new insights into atherogenesis.
The Journal of clinical investigation 2000;105(8):1039-41.
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2000: Tacken P J; Beer F D; Vark L C; Havekes L M; Hofker M H; Willems Van Dijk K
Very-low-density lipoprotein binding to the apolipoprotein E receptor 2 is enhanced by lipoprotein lipase, and does not require apolipoprotein E.
The Biochemical journal 2000;347(Pt 2):357-61.
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2000: de Winther M P; van Dijk K W; Havekes L M; Hofker M H
Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(2):290-7.
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2000: Van Eck M; Herijgers N; Van Dijk K W; Havekes L M; Hofker M H; Groot P H; Van Berkel T J
Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158-->Cys) on cholesterol levels and atherosclerosis in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):119-27.
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2000: De Winther M P; Gijbels M J; Van Dijk K W; Havekes L M; Hofker M H
Transgenic mouse models to study the role of the macrophage scavenger receptor class A in atherosclerosis.
International journal of tissue reactions 2000;22(2-3):85-91.
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2000: Willems Van Dijk K; Hofker M H; Havekes L M
Use of transgenic mice to study the role of apolipoprotein E in lipid metabolism and atherosclerosis.
International journal of tissue reactions 2000;22(2-3):49-58.
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1999: van Dijk K W; van Vlijmen B J; de Winther M P; van 't Hof B; van der Zee A; van der Boom H; Havekes L M; Hofker M H
Hyperlipidemia of ApoE2(Arg(158)-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(12):2945-51.
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1999: Mensenkamp A R; Jong M C; van Goor H; van Luyn M J; Bloks V; Havinga R; Voshol P J; Hofker M H; van Dijk K W; Havekes L M; Kuipers F
Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver.
The Journal of biological chemistry 1999;274(50):35711-8.
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1999: de Winther M P; van Dijk K W; van Vlijmen B J; Gijbels M J; Heus J J; Wijers E R; van den Bos A C; Breuer M; Frants R R; Havekes L M; Hofker M H
Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages.
Atherosclerosis 1999;147(2):339-47.
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1999: van Dijk K W; Hofker M H; Havekes L M
Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models.
Current atherosclerosis reports 1999;1(2):101-7.
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1999: Benlian P; Aalto-Setälä K; Dieplinger H; Hofker M; James R; Poledne R; Talmud P; Vilaro S
European Lipoprotein Club: report of the 21st Annual Conference, Tutzing, September 28-October 1, 1998.
Atherosclerosis 1999;144(2):449-58.
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1999: de Winther M P; Gijbels M J; van Dijk K W; van Gorp P J; suzuki H; Kodama T; Frants R R; Havekes L M; Hofker M H
Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice.
Atherosclerosis 1999;144(2):315-21.
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1999: Gijbels M J; van der Cammen M; van der Laan L J; Emeis J J; Havekes L M; Hofker M H; Kraal G
Progression and regression of atherosclerosis in APOE3-Leiden transgenic mice: an immunohistochemical study.
Atherosclerosis 1999;143(1):15-25.
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1999: de Beer F; Hendriks W L; van Vark L C; Kamerling S W; van Dijk K W; Hofker M H; Smelt A H; Havekes L M
Binding of beta-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas ApoE only modulates binding affinity.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):633-7.
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1999: Jong M C; Hofker M H; Havekes L M
Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(3):472-84.
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1999: Jong M C; van Dijk K W; Dahlmans V E; Van der Boom H; Kobayashi K; Oka K; Siest G; Chan L; Hofker M H; Havekes L M
Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor.
The Biochemical journal 1999;338 ( Pt 2)():281-7.
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1999: van Dijk K W; van Vlijmen B J; van't Hof H B; van der Zee A; Santamarina-Fojo S; van Berkel T J; Havekes L M; Hofker M H
In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE.
Journal of lipid research 1999;40(2):336-44.
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1999: Lutgens E; Daemen M; Kockx M; Doevendans P; Hofker M; Havekes L; Wellens H; de Muinck E D
Atherosclerosis in APOE*3-Leiden transgenic mice: from proliferative to atheromatous stage.
Circulation 1999;99(2):276-83.
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1998: Jong M C; Dahlmans V E; Princen H M; Hofker M H; Havekes L M
Effects of fenofibrate on hyperlipidemia and postprandial triglyceride metabolism in human apolipoprotein C1 transgenic mice.
Atherosclerosis 1998;141 Suppl 1():S77-80.
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1998: Ehnholm S; van Dijk K W; van 't Hof B; van der Zee A; Olkkonen V M; Jauhiainen M; Hofker M; Havekes L; Ehnholm C
Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice.
Journal of lipid research 1998;39(6):1248-53.
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1998: van Vlijmen B J; Mensink R P; van 't Hof H B; Offermans R F; Hofker M H; Havekes L M
Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E*3-Leiden transgenic mice.
Journal of lipid research 1998;39(6):1181-8.
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1998: van Vlijmen B J; Pearce N J; Bergö M; Staels B; Yates J W; Gribble A D; Bond B C; Hofker M H; Havekes L M; Groot P H
Apolipoprotein E*3-Leiden transgenic mice as a test model for hypolipidaemic drugs.
Arzneimittel-Forschung 1998;48(4):396-402.
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1998: Aalto-Setälä K; Benlian P; Bowyer D; Hofker M; James R W; Poledne R; Steinmetz A
European Lipoprotein Club: report of the 20th annual conference, Tutzing, 8-11 September 1997.
Atherosclerosis 1998;137(1):223-9.
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1998: Hofker M H; van Vlijmen B J; Havekes L M
Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis.
Atherosclerosis 1998;137(1):1-11.
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1998: van Dijk K W; van Vlijmen B J; van der Zee A; van't Hof B; van der Boom H; Kobayashi K; Chan L; Havekes L M; Hofker M H
Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(1):7-12.
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1998: Jong M C; Gijbels M J; Dahlmans V E; Gorp P J; Koopman S J; Ponec M; Hofker M H; Havekes L M
Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1.
The Journal of clinical investigation 1998;101(1):145-52.
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1997: Jong M C; Dahlmans V E; Hofker M H; Havekes L M
Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent manner.
The Biochemical journal 1997;328 ( Pt 3)():745-50.
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1997: Kuipers F; Jong M C; Lin Y; Eck M; Havinga R; Bloks V; Verkade H J; Hofker M H; Moshage H; Berkel T J; Vonk R J; Havekes L M
Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes.
The Journal of clinical investigation 1997;100(11):2915-22.
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1997: Havekes L M; van Vlijmen B J; Jong M C; van Dijk K W; Hofker M H
Use of transgenic mice in lipoprotein metabolism and atherosclerosis research.
Prostaglandins, leukotrienes, and essential fatty acids 1997;57(4-5):463-6.
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1997: Hendriks W L; van der Sman-de Beer F; van Vlijmen B J; van Vark L C; Hofker M H; Havekes L M
Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(3):498-504.
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1997: Jong M C; van Ree J H; Dahlmans V E; Frants R R; Hofker M H; Havekes L M
Reduced very-low-density lipoprotein fractional catabolic rate in apolipoprotein C1-deficient mice.
The Biochemical journal 1997;321 ( Pt 2)():445-50.
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1996: Florijn R J; van de Rijke F M; Vrolijk H; Blonden L A; Hofker M H; den Dunnen J T; Tanke H J; van Ommen G J; Raap A K
Exon mapping by fiber-FISH or LR-PCR.
Genomics 1996;38(3):277-82.
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1996: van Deutekom J C; Bakker E; Lemmers R J; van der Wielen M J; Bik E; Hofker M H; Padberg G W; Frants R R
Evidence for subtelomeric exchange of 3.3 kb tandemly repeated units between chromosomes 4q35 and 10q26: implications for genetic counselling and etiology of FSHD1.
Human molecular genetics 1996;5(12):1997-2003.
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1996: Jong M C; Dahlmans V E; van Gorp P J; van Dijk K W; Breuer M L; Hofker M H; Havekes L M
In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway.
The Journal of clinical investigation 1996;98(10):2259-67.
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1996: van Vlijmen B J; van Dijk K W; van't Hof H B; van Gorp P J; van der Zee A; van der Boom H; Breuer M L; Hofker M H; Havekes L M
In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice.
The Journal of biological chemistry 1996;271(48):30595-602.
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1996: Jong M C; Dahlmans V E; van Gorp P J; Breuer M L; Mol M J; van der Zee A; Frants R R; Hofker M H; Havekes L M
Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(8):934-40.
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1996: Groot P H; van Vlijmen B J; Benson G M; Hofker M H; Schiffelers R; Vidgeon-Hart M; Havekes L M
Quantitative assessment of aortic atherosclerosis in APOE*3 Leiden transgenic mice and its relationship to serum cholesterol exposure.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(8):926-33.
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1996: van Vlijmen B J; van Ree J H; Frants R R; Hofker M H; Havekes L M
Elevated levels of chylomicron- and VLDL-remnants leads to atherosclerosis in apoE transgenic mice.
Zeitschrift für Gastroenterologie 1996;34 Suppl 3():113-5.
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1996: van Deutekom J C; Lemmers R J; Grewal P K; van Geel M; Romberg S; Dauwerse H G; Wright T J; Padberg G W; Hofker M H; Hewitt J E; Frants R R
Identification of the first gene (FRG1) from the FSHD region on human chromosome 4q35.
Human molecular genetics 1996;5(5):581-90.
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1996: van Vlijmen B J; van 't Hof H B; Mol M J; van der Boom H; van der Zee A; Frants R R; Hofker M H; Havekes L M
Modulation of very low density lipoprotein production and clearance contributes to age- and gender- dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice.
The Journal of clinical investigation 1996;97(5):1184-92.
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1995: van Ree J H; van den Broek W J; Dahlmans V E; Wieringa B; Frants R R; Havekes L M; Hofker M H
Variability in cholesterol content in serum and aortic tissue in apolipoprotein E-deficient mice is comparable in inbred (129/Sv) and outbred (mixed 129/Sv and C57BL/6) mice.
Atherosclerosis 1995;118(1):165-7.
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1995: van Dijk K W; Steketee K; Havekes L; Frants R; Hofker M
Genomic and cDNA cloning of a novel mouse lipoxygenase gene.
Biochimica et biophysica acta 1995;1259(1):4-8.
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1995: van Ree J H; van den Broek W J; van der Zee A; Dahlmans V E; Wieringa B; Frants R R; Havekes L M; Hofker M H
Inactivation of Apoe and Apoc1 by two consecutive rounds of gene targeting: effects on mRNA expression levels of gene cluster members.
Human molecular genetics 1995;4(8):1403-9.
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1995: van Ree J H; Hofker M H; van den Broek W J; van Deursen J M; van der Boom H; Frants R R; Wieringa B; Havekes L M
Increased response to cholesterol feeding in apolipoprotein C1-deficient mice.
The Biochemical journal 1995;305 ( Pt 3)():905-11.
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1995: van Ree J H; Gijbels M J; van den Broek W J; Hofker M H; Havekes L M
Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding.
Atherosclerosis 1995;112(2):237-43.
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1995: van Deutekom J C; Hofker M H; Romberg S; van Geel M; Rommens J; Wright T J; Hewitt J E; Padberg G W; Wijmenga C; Frants R R
Search for the FSHD gene using cDNA selection in a region spanning 100 kb on chromosome 4q35.
Muscle & nerve 1995;2():S19-26.
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1995: Wijmenga C; Dauwerse H G; Padberg G W; Meyer N; Murray J C; Mills K; van Ommen G B; Hofker M H; Frants R R
Fish mapping of 250 cosmid and 26 YAC clones to chromosome 4 with special emphasis on the FSHD region at 4q35.
Muscle & nerve 1995;2():S14-8.
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1994: van Ree J H; van den Broek W J; Dahlmans V E; Groot P H; Vidgeon-Hart M; Frants R R; Wieringa B; Havekes L M; Hofker M H
Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice.
Atherosclerosis 1994;111(1):25-37.
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1994: van der Zee A; Stas L; Hilleker C; van Leuven F; van Dijk K W; Havekes L; Frants R; Hofker M
Genomic cloning of the mouse LDL receptor related protein/alpha 2-macroglobulin receptor gene.
Genomics 1994;23(1):256-9.
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1994: Hewitt J E; Lyle R; Clark L N; Valleley E M; Wright T J; Wijmenga C; van Deutekom J C; Francis F; Sharpe P T; Hofker M
Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystrophy.
Human molecular genetics 1994;3(8):1287-95.
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1994: van Eck M M; Hoffer M J; Havekes L M; Frants R R; Hofker M H
The apolipoprotein C2-linked (Acl) gene: a new gene within the mouse apolipoprotein e-c1-c2 gene cluster.
Genomics 1994;21(1):110-5.
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1994: van Vlijmen B J; van den Maagdenberg A M; Gijbels M J; van der Boom H; HogenEsch H; Frants R R; Hofker M H; Havekes L M
Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice.
The Journal of clinical investigation 1994;93(4):1403-10.
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1994: Wijmenga C; van Deutekom J C; Hewitt J E; Padberg G W; van Ommen G J; Hofker M H; Frants R R
Pulsed-field gel electrophoresis of the D4F104S1 locus reveals the size and the parental origin of the facioscapulohumeral muscular dystrophy (FSHD)-associated deletions.
Genomics 1994;19(1):21-6.
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1993: van Deutekom J C; Wijmenga C; van Tienhoven E A; Gruter A M; Hewitt J E; Padberg G W; van Ommen G J; Hofker M H; Frants R R
FSHD associated DNA rearrangements are due to deletions of integral copies of a 3.2 kb tandemly repeated unit.
Human molecular genetics 1993;2(12):2037-42.
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1993: Hoffer M J; van Eck M M; Havekes L M; Hofker M H; Frants R R
The mouse apolipoprotein C1 gene: structure and expression.
Genomics 1993;18(1):37-42.
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1993: Wijmenga C; Wright T J; Baan M J; Padberg G W; Williamson R; van Ommen G J; Hewitt J E; Hofker M H; Frants R R
Physical mapping and YAC-cloning connects four genetically distinct 4qter loci (D4S163, D4S139, D4F35S1 and D4F104S1) in the FSHD gene-region.
Human molecular genetics 1993;2(10):1667-72.
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1993: Wijmenga C; Frants R R; Hewitt J E; van Deutekom J C; van Geel M; Wright T J; Padberg G W; Hofker M H; van Ommen G J
Molecular genetics of facioscapulohumeral muscular dystrophy.
Neuromuscular disorders : NMD 1993;3(5-6):487-91.
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1993: Wijmenga C; Winokur S T; Padberg G W; Skraastad M I; Altherr M R; Wasmuth J J; Murray J C; Hofker M H; Frants R R
The human skeletal muscle adenine nucleotide translocator gene maps to chromosome 4q35 in the region of the facioscapulohumeral muscular dystrophy locus.
Human genetics 1993;92(2):198-203.
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1993: Hoffer M J; van Eck M M; Havekes L M; Hofker M H; Frants R R
Structure and expression of the mouse apolipoprotein C2 gene.
Genomics 1993;17(1):45-51.
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1993: van den Maagdenberg A M; Weng W; de Bruijn I H; de Knijff P; Funke H; Smelt A H; Gevers Leuven J A; van't Hooft F M; Assmann G; Hofker M H
Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E: no cosegregation with severe hyperlipidemia.
American journal of human genetics 1993;52(5):937-46.
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1993: van den Maagdenberg A M; Hofker M H; Krimpenfort P J; de Bruijn I; van Vlijmen B; van der Boom H; Havekes L M; Frants R R
Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia.
The Journal of biological chemistry 1993;268(14):10540-5.
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1993: Hoffer M J; van Eck M M; Petrij F; van der Zee A; de Wit E; Meijer D; Grosveld G; Havekes L M; Hofker M H; Frants R R
The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure.
Biochemical and biophysical research communications 1993;191(3):880-6.
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1993: Hoffer M J; Hofker M H; van Eck M M; Havekes L M; Frants R R
Evolutionary conservation of the mouse apolipoprotein e-c1-c2 gene cluster: structure and genetic variability in inbred mice.
Genomics 1993;15(1):62-7.
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1993: Wijmenga C; Hofker M H; Padberg G W; Frants R R
Genetic mapping of facioscapulohumeral muscular dystrophy.
Molecular and cell biology of human diseases series 1993;3():111-38.
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1992: Wijmenga C; Hewitt J E; Sandkuijl L A; Clark L N; Wright T J; Dauwerse H G; Gruter A M; Hofker M H; Moerer P; Williamson R
Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy.
Nature genetics 1992;2(1):26-30.
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1989: Hofker M H; Nukiwa T; van Paassen H M; Nelen M; Kramps J A; Klasen E C; Frants R R; Crystal R G
A Pro----Leu substitution in codon 369 of the alpha-1-antitrypsin deficiency variant PI MHeerlen.
Human genetics 1989;81(3):264-8.
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1988: Hofker M H; Nelen M; Klasen E C; Nukiwa T; Curiel D; Crystal R G; Frants R R
Cloning and characterization of an alpha 1-antitrypsin like gene 12 KB downstream of the genuine alpha 1-antitrypsin gene.
Biochemical and biophysical research communications 1988;155(2):634-42.
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1988: Zelle B; Evers M P; Groot P C; Bebelman J P; Mager W H; Planta R J; Pronk J C; Meuwissen S G; Hofker M H; Eriksson A W
Genomic structure and evolution of the human pepsinogen A multigene family.
Human genetics 1988;78(1):79-82.
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1987: Klasen E C; Hofker M H; van Paassen H M; Verlaan-de Vries M; Bos J L; Frants R R
Detection of alpha-1-antitrypsin deficiency variants by synthetic oligonucleotide hybridization.
Clinica chimica acta; international journal of clinical chemistry 1987;170(2-3):201-7.
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1987: Carpenter N J; Veenema H; Bakker E; Hofker M H; Pearson P L
A new DNA probe proximal to and closely linked to fragile X.
American journal of medical genetics 1987;27(3):731-2.
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1987: Veenema H; Carpenter N J; Bakker E; Hofker M H; Ward A M; Pearson P L
The fragile X syndrome in a large family. III. Investigations on linkage of flanking DNA markers with the fragile site Xq27.
Journal of medical genetics 1987;24(7):413-21.
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1987: Hofker M H; Bergen A A; Skraastad M I; Carpenter N J; Veenema H; Connor J M; Bakker E; van Ommen G J; Pearson P L
Efficient isolation of X chromosome-specific single-copy probes from a cosmid library of a human X/hamster hybrid-cell line: mapping of new probes close to the locus for X-linked mental retardation.
American journal of human genetics 1987;40(4):312-28.
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1986: Bakker E; Bonten E J; De Lange L F; Veenema H; Majoor-Krakauer D; Hofker M H; Van Ommen G J; Pearson P L
DNA probe analysis for carrier detection and prenatal diagnosis of Duchenne muscular dystrophy: a standard diagnostic procedure.
Journal of medical genetics 1986;23(6):573-80.
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1986: Hofker M H; Bergen A A; Skraastad M I; Bakker E; Francke U; Wieringa B; Bartley J; van Ommen G J; Pearson P L
Isolation of a random cosmid clone, cX5, which defines a new polymorphic locus DXS148 near the locus for Duchenne muscular dystrophy.
Human genetics 1986;74(3):275-9.
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1986: Hofker M H; Skraastad M I; Bergen A A; Wapenaar M C; Bakker E; Millington-Ward A; van Ommen G J; Pearson P L
The X chromosome shows less genetic variation at restriction sites than the autosomes.
American journal of human genetics 1986;39(4):438-51.
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1985: Hofker M H; Wapenaar M C; Goor N; Bakker E; van Ommen G J; Pearson P L
Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophy.
Human genetics 1985;70(2):148-56.
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