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Gerhard Höfle

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Gerhard Höfle; Brigitte Kunze; Edgar Forche; Klaus Gerth; Hans Reichenbach; Florenz Sasse; Evgeny V Prusov
Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex I inhibitor.
Christine Jahns; Markus Kalesse; Klaus Gerth; Thomas Hoffmann; Gerhard Höfle; Stefan Müller; Hans Reichenbach; Peter Washausen; Rolf Müller
Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum.
Wiebke Zander; Heinrich Steinmetz; Hermann Augustiniak; Klaus Gerth; Martina Herrmann; Gerhard Höfle; Herbert Irschik; Rolf Jansen; Markus Kalesse; Wolfgang Kessler; Rolf Müller
Sulfangolids, macrolide sulfate esters from Sorangium cellulosum.

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2012: Gerhard Höfle; Brigitte Kunze; Edgar Forche; Klaus Gerth; Hans Reichenbach; Florenz Sasse; Evgeny V Prusov
Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex I inhibitor.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(36):11362-70.
2012: Christine Jahns; Markus Kalesse; Klaus Gerth; Thomas Hoffmann; Gerhard Höfle; Stefan Müller; Hans Reichenbach; Peter Washausen; Rolf Müller
Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum.
Angewandte Chemie (International ed. in English) 2012;51(21):5239-43.
2012: Wiebke Zander; Heinrich Steinmetz; Hermann Augustiniak; Klaus Gerth; Martina Herrmann; Gerhard Höfle; Herbert Irschik; Rolf Jansen; Markus Kalesse; Wolfgang Kessler; Rolf Müller
Sulfangolids, macrolide sulfate esters from Sorangium cellulosum.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(20):6264-71.
2012: Jenny Barbier; Stefan Benson; Bettina Böhlendorf; Klaus Gerth; Gerhard Höfle; Herbert Irschik; Rolf Jansen; Andreas Kirschning; Hans Reichenbach; Jens Wegner; Carsten Zeilinger; Rolf Müller
Isolation and total synthesis of icumazoles and noricumazoles--antifungal antibiotics and cation-channel blockers from Sorangium cellulosum.
Angewandte Chemie (International ed. in English) 2012;51(5):1256-60.
2009: Gerhard Höfle
The epothilones: an outstanding family of anti-tumor agents. General aspects.
Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles 2009;90():5-28.
2008: Gerhard Höfle; Brigitte Kunze
Biosynthesis of aurachins A-L in Stigmatella aurantiaca: a feeding study.
Journal of natural products 2008;71(11):1843-9.
2008: Gerhard Höfle; Herbert Irschik
Isolation and biosynthesis of aurachin P and 5-nitroresorcinol from Stigmatella erecta.
Journal of natural products 2008;71(11):1946-8.
2008: Gerhard Höfle; Bettina Bööhlendorf; Thomas Fecker; Florenz Sasse; Brigitte Kunze
Semisynthesis and antiplasmodial activity of the quinoline alkaloid aurachin E.
Journal of natural products 2008;71(11):1967-9.
2008: Brigitte Kunze; Bettina Böhlendorf; Hans Reichenbach; Gerhard Höfle
Pedein A and B: production, isolation, structure elucidation and biological properties of new antifungal cyclopeptides from Chondromyces pediculatus (Myxobacteria).
The Journal of antibiotics 2008;61(1):18-26.
2008: Hans Reichenbach; Gerhard Höfle
Discovery and development of the epothilones : a novel class of antineoplastic drugs.
Drugs in R&D 2008;9(1):1-10.
2008: Klaus Gerth; Heinrich Steinmetz; Gerhard Höfle; Rolf Jansen
Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, So ce1525.
Angewandte Chemie (International ed. in English) 2008;47(3):600-2.
2007: Herbert Irschik; Hans Reichenbach; Gerhard Höfle; Rolf Jansen
The thuggacins, novel antibacterial macrolides from Sorangium cellulosum acting against selected Gram-positive bacteria.
The Journal of antibiotics 2007;60(12):733-8.
2007: Larissa Jundt; Gerhard Höfle
Side-chain truncation of apicularen A by olefin cross-metathesis with ethylene.
Journal of natural products 2007;70(8):1377-9.
2007: Herbert Irschik; Dietmar Schummer; Gerhard Höfle; Hans Reichenbach; Heinrich Steinmetz; Rolf Jansen
Etnangien, a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases.
Journal of natural products 2007;70(6):1060-3.
2007: Heinrich Steinmetz; Herbert Irschik; Brigitte Kunze; Hans Reichenbach; Gerhard Höfle; Rolf Jansen
Thuggacins, macrolide antibiotics active against Mycobacterium tuberculosis: isolation from myxobacteria, structure elucidation, conformation analysis and biosynthesis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(20):5822-32.
2006: Brigitte Kunze; Heinrich Steinmetz; Gerhard Höfle; Markus Huss; Helmut Wieczorek; Hans Reichenbach
Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (myxobacteria) with inhibitory effect on mitochondrial ATPase activity. Fermentation and biological properties.
The Journal of antibiotics 2006;59(10):664-8.
2005: Brigitte Kunze; Hans Reichenbach; Rolf Müller; Gerhard Höfle
Aurafuron A and B, new bioactive polyketides from Stigmatella aurantiaca and Archangium gephyra (Myxobacteria). Fermentation, isolation, physico-chemical properties, structure and biological activity.
The Journal of antibiotics 2005;58(4):244-51.
2005: Silke C Wenzel; Brigitte Kunze; Gerhard Höfle; Barbara Silakowski; Maren Scharfe; Helmut Blöcker; Rolf Müller
Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis.
Chembiochem : a European journal of chemical biology 2005;6(2):375-85.
2004: Heinrich Steinmetz; Nicole Glaser; Eberhardt Herdtweck; Florenz Sasse; Hans Reichenbach; Gerhard Höfle
Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria.
Angewandte Chemie (International ed. in English) 2004;43(37):4888-92.
2004: Helge B Bode; Silke C Wenzel; Herbert Irschik; Gerhard Höfle; Rolf Müller
Unusual biosynthesis of leupyrrins in the myxobacterium Sorangium cellulosum.
Angewandte Chemie (International ed. in English) 2004;43(32):4163-7.
2004: Brigitte Kunze; Rolf Jansen; Gerhard Höfle; Hans Reichenbach
Ajudazols, new inhibitors of the mitochondrial electron transport from Chondromyces crocatus. Production, antimicrobial activity and mechanism of action.
The Journal of antibiotics 2004;57(2):151-5.
2003: Florenz Sasse; Thomas Leibold; Brigitte Kunze; Gerhard Höfle; Hans Reichenbach
Cyrmenins, new beta-methoxyacrylate inhibitors of the electron transport. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 2003;56(10):827-31.
2003: Helge B Bode; Herbert Irschik; Silke C Wenzel; Hans Reichenbach; Rolf Müller; Gerhard Höfle
The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum.
Journal of natural products 2003;66(9):1203-6.
2003: Mario Köster; Søren Lykke-Andersen; Yasser A Elnakady; Klaus Gerth; Peter Washausen; Gerhard Höfle; Florenz Sasse; Jørgen Kjems; Hansjörg Hauser
Ratjadones inhibit nuclear export by blocking CRM1/exportin 1.
Experimental cell research 2003;286(2):321-31.
2003: Florenz Sasse; Heinrich Steinmetz; Gerhard Höfle; Hans Reichenbach
Archazolids, new cytotoxic macrolactones from Archangium gephyra (Myxobacteria). Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 2003;56(6):520-5.
2002: Alicia Regueiro-Ren; Kenneth J Leavitt; Soong-Hoon Kim; Gerhard Höfle; Michael Kiffe; Jack Z Gougoutas; John D DiMarco; Francis Y Lee; Craig R Fairchild; Byron H Long; Gregory D Vite
SAR and pH stability of cyano-substituted epothilones.
Organic letters 2002;4(22):3815-8.
2002: Taifo Mahmud; Helge B Bode; Barbara Silakowski; Reiner M Kroppenstedt; Mingjie Xu; Sonja Nordhoff; Gerhard Höfle; Rolf Müller
A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteria.
The Journal of biological chemistry 2002;277(36):32768-74.
2002: Florenz Sasse; Heinrich Steinmetz; Thomas Schupp; Frank Petersen; Klaus Memmert; Hans Hofmann; Christoph Heusser; Volker Brinkmann; Peter von Matt; Gerhard Höfle; Hans Reichenbach
Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 2002;55(6):543-51.
2002: Nikolaos Gaitatzis; Barbara Silakowski; Brigitte Kunze; Gabriele Nordsiek; Helmut Blöcker; Gerhard Höfle; Rolf Müller
The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase.
The Journal of biological chemistry 2002;277(15):13082-90.
2001: I H Hardt; Heinrich Steinmetz; Klaus Gerth; Florenz Sasse; Hans Reichenbach; Gerhard Höfle
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.
Journal of natural products 2001;64(7):847-56.
2001: Klaus Gerth; Heinrich Steinmetz; Gerhard Höfle; Hans Reichenbach
Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase.
The Journal of antibiotics 2001;54(2):144-8.
2000: Klaus Gerth; Heinrich Steinmetz; Gerhard Höfle; Hans Reichenbach
Studies on the biosynthesis of epothilones: the biosynthetic origin of the carbon skeleton.
The Journal of antibiotics 2000;53(12):1373-7.
2000: Barbara Silakowski; Brigitte Kunze; Gabriele Nordsiek; Helmut Blöcker; Gerhard Höfle; Rolf Müller
The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15.
European journal of biochemistry / FEBS 2000;267(21):6476-85.
2000: Florenz Sasse; Heinrich Steinmetz; J Heil; Gerhard Höfle; Hans Reichenbach
Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 2000;53(9):879-85.
1999: Barbara Silakowski; HU Schairer; H Ehret; Brigitte Kunze; Stefan Weinig; Gabriele Nordsiek; P Brandt; Helmut Blöcker; Gerhard Höfle; Stefan Beyer; Rolf Müller
New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.
The Journal of biological chemistry 1999;274(52):37391-9.
1999: Florenz Sasse; B Böhlendorf; M Herrmann; Brigitte Kunze; E Forche; Heinrich Steinmetz; Gerhard Höfle; Hans Reichenbach; M Hermann
Melithiazols, new beta-methoxyacrylate inhibitors of the respiratory chain isolated from myxobacteria. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1999;52(8):721-9.
1998: Brigitte Kunze; Rolf Jansen; Florenz Sasse; Gerhard Höfle; Hans Reichenbach
Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties.
The Journal of antibiotics 1998;51(12):1075-80.
1998: M Sefkow; Michael Kiffe; Gerhard Höfle
Derivatization of the C12-C13 functional groups of epothilones A, B and C.
Bioorganic & medicinal chemistry letters 1998;8(21):3031-6.
1998: M Sefkow; Michael Kiffe; D Schummer; Gerhard Höfle
Oxidative and reductive transformations of epothilone A.
Bioorganic & medicinal chemistry letters 1998;8(21):3025-30.
1996: K Gerth; N Bedorf; Gerhard Höfle; H Irschik; Hans Reichenbach
Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties.
The Journal of antibiotics 1996;49(6):560-3.
1995: Brigitte Kunze; R Jansen; Florenz Sasse; Gerhard Höfle; Hans Reichenbach
Chondramides A approximately D, new antifungal and cytostatic depsipeptides from Chondromyces crocatus (myxobacteria). Production, physico-chemical and biological properties.
The Journal of antibiotics 1995;48(11):1262-6.
1995: K Gerth; D Schummer; Gerhard Höfle; H Irschik; Hans Reichenbach
Ratjadon: a new antifungal compound from Sorangium cellulosum (myxobacteria) production, physio-chemical and biological properties.
The Journal of antibiotics 1995;48(9):973-6.
1995: H Irschik; R Jansen; K Gerth; Gerhard Höfle; Hans Reichenbach
Chivosazol A, a new inhibitor of eukaryotic organisms isolated from myxobacteria.
The Journal of antibiotics 1995;48(9):962-6.
1995: H Irschik; R Jansen; K Gerth; Gerhard Höfle; Hans Reichenbach
Sorangiolid A, a new antibiotic isolated from the myxobacterium Sorangium cellulosum So ce 12.
The Journal of antibiotics 1995;48(8):886-7.
1995: H Irschik; H Augustiniak; K Gerth; Gerhard Höfle; Hans Reichenbach
The ripostatins, novel inhibitors of eubacterial RNA polymerase isolated from myxobacteria.
The Journal of antibiotics 1995;48(8):787-92.
1995: H Irschik; R Jansen; K Gerth; Gerhard Höfle; Hans Reichenbach
Disorazol A, an efficient inhibitor of eukaryotic organisms isolated from myxobacteria.
The Journal of antibiotics 1995;48(1):31-5.
1995: Florenz Sasse; H Steinmetz; Gerhard Höfle; Hans Reichenbach
Gephyronic acid, a novel inhibitor of eukaryotic protein synthesis from Archangium gephyra (myxobacteria). Production, isolation, physico-chemical and biological properties, and mechanism of action.
The Journal of antibiotics 1995;48(1):21-5.
1995: H Irschik; D Schummer; K Gerth; Gerhard Höfle; Hans Reichenbach
The tartrolons, new boron-containing antibiotics from a myxobacterium, Sorangium cellulosum.
The Journal of antibiotics 1995;48(1):26-30.
1994: Brigitte Kunze; R Jansen; Gerhard Höfle; Hans Reichenbach
Crocacin, a new electron transport inhibitor from Chondromyces crocatus (myxobacteria). Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1994;47(8):881-6.
1994: Thorsten Friedrich; Tomoko Ohnishi; E Forche; Brigitte Kunze; R Jansen; W Trowitzsch; Gerhard Höfle; Hans Reichenbach; Hanns Weiss
Two binding sites for naturally occurring inhibitors in mitochondrial and bacterial NADH:ubiquinone oxidoreductase (complex I).
Biochemical Society transactions 1994;22(1):226-30.
1994: Thorsten Friedrich; P van Heek; H Leif; Tomoko Ohnishi; E Forche; Brigitte Kunze; R Jansen; W Trowitzsch-Kienast; Gerhard Höfle; Hans Reichenbach
Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase.
European journal of biochemistry / FEBS 1994;219(1-2):691-8.
1994: K Gerth; N Bedorf; H Irschik; Gerhard Höfle; Hans Reichenbach
The soraphens: a family of novel antifungal compounds from Sorangium cellulosum (Myxobacteria). I. Soraphen A1 alpha: fermentation, isolation, biological properties.
The Journal of antibiotics 1994;47(1):23-31.
1993: Brigitte Kunze; R Jansen; L Pridzun; E Jurkiewicz; G Hunsmann; Gerhard Höfle; Hans Reichenbach
Thiangazole, a new thiazoline antibiotic from Polyangium sp. (myxobacteria): production, antimicrobial activity and mechanism of action.
The Journal of antibiotics 1993;46(11):1752-5.
1993: Florenz Sasse; H Steinmetz; Gerhard Höfle; Hans Reichenbach
Rhizopodin, a new compound from Myxococcus stipitatus (myxobacteria) causes formation of rhizopodia-like structures in animal cell cultures. Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1993;46(5):741-8.
1993: Hans Reichenbach; Gerhard Höfle
Biologically active secondary metabolites from myxobacteria.
Biotechnology advances 1993;11(2):219-77.
1992: Brigitte Kunze; R Jansen; L Pridzun; E Jurkiewicz; G Hunsmann; Gerhard Höfle; Hans Reichenbach
Phenoxan, a new oxazole-pyrone from myxobacteria: production, antimicrobial activity and its inhibition of the electron transport in complex I of the respiratory chain.
The Journal of antibiotics 1992;45(9):1549-52.
1992: Brigitte Kunze; W Trowitzsch-Kienast; Gerhard Höfle; Hans Reichenbach
Nannochelins A, B and C, new iron-chelating compounds from Nannocystis exedens (myxobacteria). Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1992;45(2):147-50.
1991: Udo Gräfe; W Ihn; Brigitte Schlegel; Gerhard Höfle; H Augustiniak; P Sandor
Structure of ergokonin C, a new carboxysterol antifungal antibiotic from a Tolypocladium inflatum mutant.
Die Pharmazie 1991;46(8):613-4.
1989: Brigitte Kunze; N Bedorf; W Kohl; Gerhard Höfle; Hans Reichenbach
Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties.
The Journal of antibiotics 1989;42(1):14-7.
1988: H Irschik; W Trowitzsch-Kienast; K Gerth; Gerhard Höfle; Hans Reichenbach
Saframycin Mx1, a new natural saframycin isolated from a myxobacterium.
The Journal of antibiotics 1988;41(8):993-8.
1987: Brigitte Kunze; Gerhard Höfle; Hans Reichenbach
The aurachins, new quinoline antibiotics from myxobacteria: production, physico-chemical and biological properties.
The Journal of antibiotics 1987;40(3):258-65.
1987: H Irschik; R Jansen; K Gerth; Gerhard Höfle; Hans Reichenbach
The sorangicins, novel and powerful inhibitors of eubacterial RNA polymerase isolated from myxobacteria.
The Journal of antibiotics 1987;40(1):7-13.
1985: Brigitte Kunze; W Kohl; Gerhard Höfle; Hans Reichenbach
Production, isolation, physico-chemical and biological properties of angiolam A, a new antibiotic from Angiococcus disciformis (Myxobacterales).
The Journal of antibiotics 1985;38(12):1649-54.
1985: H Irschik; R Jansen; Gerhard Höfle; K Gerth; Hans Reichenbach
The corallopyronins, new inhibitors of bacterial RNA synthesis from Myxobacteria.
The Journal of antibiotics 1985;38(2):145-52.
1984: Brigitte Kunze; T Kemmer; Gerhard Höfle; Hans Reichenbach
Stigmatellin, a new antibiotic from Stigmatella aurantiaca (Myxobacterales). I. Production, physico-chemical and biological properties.
The Journal of antibiotics 1984;37(5):454-61.
1983: H Irschik; K Gerth; Gerhard Höfle; W Kohl; Hans Reichenbach
The myxopyronins, new inhibitors of bacterial RNA synthesis from Myxococcus fulvus (Myxobacterales).
The Journal of antibiotics 1983;36(12):1651-8.
1983: K Gerth; R Jansen; G Reifenstahl; Gerhard Höfle; H Irschik; Brigitte Kunze; Hans Reichenbach; G Thierbach
The myxalamids, new antibiotics from Myxococcus xanthus (Myxobacterales). I. Production, physico-chemical and biological properties, and mechanism of action.
The Journal of antibiotics 1983;36(9):1150-6.
1982: K Gerth; W Trowitzsch; V Wray; Gerhard Höfle; H Irschik; Hans Reichenbach
Pyrrolnitrin from Myxococcus fulvus (Myxobacterales).
The Journal of antibiotics 1982;35(8):1101-3.
1982: Brigitte Kunze; Hans Reichenbach; H Augustiniak; Gerhard Höfle
Isolation and identification of althiomycin from Cystobacter fuscus (myxobacterales).
The Journal of antibiotics 1982;35(5):635-6.
1981: H Anke; T Kemmer; Gerhard Höfle
Deflectins, new antimicrobial azaphilones from Aspergillus deflectus.
The Journal of antibiotics 1981;34(8):923-8.