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Alan Hofmann

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lee hagey; Alan F Hofmann; Shigeo Ikegawa; Narimi Kato; Kuniko Mitamura; Shoujiro Ogawa; Rika Satoh née Okihara; Mizuho Une; Takashi Iida
A novel varanic acid epimer--(24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster.
lee hagey; Yuuki Adachi; Takashi Iida; Masamitsu Maekawa; Nariyasu Mano; Kumiko Mushiake; Shoujiro Ogawa; Miki Shimada; Mizuho Une; Alan F Hofmann
Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid.
Shoujiro Ogawa; lee hagey; Alan F Hofmann; Shigeo Ikegawa; Matthew D Krasowski; Kuniko Mitamura; Takashi Iida
Chemical synthesis of the (25R)- and (25S)-epimers of 3α,7α,12α-trihydroxy-5α-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates.

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All Publications

2012: lee hagey; Alan F Hofmann; Shigeo Ikegawa; Narimi Kato; Kuniko Mitamura; Shoujiro Ogawa; Rika Satoh née Okihara; Mizuho Une; Takashi Iida
A novel varanic acid epimer--(24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster.
Steroids 2012;77(13):1510-21.
2011: lee hagey; Yuuki Adachi; Takashi Iida; Masamitsu Maekawa; Nariyasu Mano; Kumiko Mushiake; Shoujiro Ogawa; Miki Shimada; Mizuho Une; Alan F Hofmann
Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid.
Steroids 2011;76(10-11):1126-35.
2011: Shoujiro Ogawa; lee hagey; Alan F Hofmann; Shigeo Ikegawa; Matthew D Krasowski; Kuniko Mitamura; Takashi Iida
Chemical synthesis of the (25R)- and (25S)-epimers of 3α,7α,12α-trihydroxy-5α-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates.
Chemistry and physics of lipids 2011;164(5):368-77.
2011: Alan F Hofmann
Bile acid sequestrants improve glycemic control in type 2 diabetes: a proposed mechanism implicating glucagon-like peptide 1 release.
Hepatology (Baltimore, Md.) 2011;53(5):1784.
2011: Alan F Hofmann
Herbert Falk: a vital force in the renaissance of bile acid research and bile acid therapy.
Digestive diseases (Basel, Switzerland) 2011;29(1):23-36.
2010: lee hagey; Takashi Lida; Hideyuki Tamegai; Shoujiro Ogawa; Mizuho Une; Kiyoshi Asahina; Kumiko Mushiake; Takaaki Goto; Nariyasu Mano; Junichi Goto; Matthew D Krasowski; Alan F Hofmann
Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid.
Zoological science 2010;27(7):565-73.
2010: lee hagey; Peter R Møller; Alan F Hofmann; Matthew D Krasowski
Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway.
Physiological and biochemical zoology : PBZ 2010;83(2):308-21.
2010: Alan F Hofmann; lee hagey; Matthew D Krasowski
Bile salts of vertebrates: structural variation and possible evolutionary significance.
Journal of lipid research 2010;51(2):226-46.
2010: lee hagey; Nicolas Vidal; Alan F Hofmann; Matthew D Krasowski
Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites.
BMC evolutionary biology 2010;10():133.
2009: Alan F Hofmann
Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last.
Expert review of gastroenterology & hepatology 2009;3(5):461-4.
2009: Genta Kakiyama; Akina Muto; Miki Shimada; Nariyasu Mano; Junichi Goto; Alan F Hofmann; Takashi Iida
Chemical synthesis of 3beta-sulfooxy-7beta-hydroxy-24-nor-5-cholenoic acid: an internal standard for mass spectrometric analysis of the abnormal delta5-bile acids occurring in Niemann-Pick disease.
Steroids 2009;74(9):766-72.
2009: Alan F Hofmann
Bile acids: trying to understand their chemistry and biology with the hope of helping patients.
Hepatology (Baltimore, Md.) 2009;49(5):1403-18.
2009: lee hagey; Genta Kakiyama; Akina Muto; Takashi Iida; Kumiko Mushiake; Takaaki Goto; Nariyasu Mano; Junichi Goto; Cleida A Oliveira; Alan F Hofmann
A new, major C27 biliary bile acid in the red-winged tinamou (Rhynchotus rufescens):25R-1beta, 3alpha,7alpha-trihydroxy-5beta-cholestan-27-oic acid.
Journal of lipid research 2009;50(4):651-7.
2009: Alan F Hofmann
The enterohepatic circulation of bile acids in mammals: form and functions.
Frontiers in bioscience : a journal and virtual library 2009;14():2584-98.
2009: Alan F Hofmann
In memoriam: Dr. Herbert Falk (1924-2008).
Hepatology (Baltimore, Md.) 2009;49(1):1-3.
2008: Alan F Hofmann; Vera Loening-Baucke; Joel Edward Lavine; lee hagey; Joseph H Steinbach; Christine A Packard; Terrance L Griffin; Dale A Chatfield
Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients.
Journal of pediatric gastroenterology and nutrition 2008;47(5):598-606.
2008: Alan F Hofmann; lee hagey
Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics.
Cellular and molecular life sciences : CMLS 2008;65(16):2461-83.
2007: Genta Kakiyama; Hideyuki Tamegai; Takashi Iida; Kuniko Mitamura; Shigeo Ikegawa; Takaaki Goto; Nariyasu Mano; Junichi Goto; Peter Holz; lee hagey; Alan F Hofmann
Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15alpha-hydroxylithocholic acid.
Journal of lipid research 2007;48(12):2682-92.
2007: James P Hamilton; Guofeng Xie; Jean-Pierre Raufman; Susan Hogan; Terrance L Griffin; Christine A Packard; Dale A Chatfield; lee hagey; Joseph H Steinbach; Alan F Hofmann
Human cecal bile acids: concentration and spectrum.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(1):G256-63.
2007: Takashi Iida; Shoujiro Ogawa; Keiji Hosoi; Mitsuko Makino; Yasuo Fujimoto; Takaaki Goto; Nariyasu Mano; Junichi Goto; Alan F Hofmann
Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: osmiumporphyrin complex/tert-butyl hydroperoxide system.
The Journal of organic chemistry 2007;72(3):823-30.
2007: Stephen J Keely; Michael M Scharl; Lone S Bertelsen; lee hagey; Kim E Barrett; Alan F Hofmann
Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships.
American journal of physiology. Gastrointestinal and liver physiology 2007;292(1):G290-7.
2006: Ephraim Sehayek; lee hagey; Yee-Yan Fung; Elizabeth M Duncan; Hannah J Yu; Gösta Eggertsen; Ingemar Björkhem; Alan F Hofmann; Jan L Breslow
Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit.
Journal of lipid research 2006;47(9):2020-7.
2006: Coen C Paulusma; Annemiek Groen; Cindy Kunne; Kam S Ho-Mok; Astrid L Spijkerboer; D Rudi de Waart; Frans J Hoek; Heleen Vreeling; Kees A Hoeben; Jan van Marle; Ludmila Pawlikowska; Laura N Bull; Alan F Hofmann; Alex S Knisely; Ronald P J Oude Elferink
Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.
Hepatology (Baltimore, Md.) 2006;44(1):195-204.
2006: Genta Kakiyama; Takashi Iida; Takaaki Goto; Nariyasu Mano; Junichi Goto; Toshio Nambara; lee hagey; Claudio D Schteingart; Alan F Hofmann
Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid.
Journal of lipid research 2006;47(7):1551-8.
2006: Takashi Iida; Genta Kakiyama; Yohei Hibiya; Shohei Miyata; Takehiko Inoue; Kohsaku Ohno; Takaaki Goto; Nariyasu Mano; Junichi Goto; Toshio Nambara; Alan F Hofmann
Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3beta,7beta-dihydroxy-5-cholen-24-oic acid, and related compounds: unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1.
Steroids 2006;71(1):18-29.
2005: Alan F Hofmann; Salam F Zakko; Marco Lira; Carlo Clerici; lee hagey; K Karel Lambert; Joseph H Steinbach; Claudio D Schteingart; Peter Olinga; Geny M M Groothuis
Novel biotransformation and physiological properties of norursodeoxycholic acid in humans.
Hepatology (Baltimore, Md.) 2005;42(6):1391-8.
2005: Antonio Moschetta; Fang Xu; lee hagey; Gerard P van Berge-Henegouwen; Karel J van Erpecum; Jos F Brouwers; Jonathan C Cohen; Molly Bierman; Helen H Hobbs; Joseph H Steinbach; Alan F Hofmann
A phylogenetic survey of biliary lipids in vertebrates.
Journal of lipid research 2005;46(10):2221-32.
2005: Alan F Hofmann
Increased deoxycholic acid absorption and gall stones in acromegalic patients treated with octreotide: more evidence for a connection between slow transit constipation and gall stones.
Gut 2005;54(5):575-8.
2004: Alan F Hofmann
Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity.
Drug metabolism reviews 2004;36(3-4):703-22.
2004: Aida Jover; Francisco Meijide; Victor H Soto; José Vázquez Tato; E Rodríguez Núñez; Huong-Thu Ton-Nu; Alan F Hofmann
Successful prediction of the hydrogen bond network of the 3-oxo-12alpha-hydroxy-5beta-cholan-24-oic acid crystal from resolution of the crystal structure of deoxycholic acid and its three 3,12-dihydroxy epimers.
Steroids 2004;69(6):379-88.
2004: Genta Kakiyama; Takashi Iida; Atsushi Yoshimoto; Takaaki Goto; Nariyasu Mano; Junichi Goto; Toshio Nambara; lee hagey; Alan F Hofmann
Chemical synthesis of (22E)-3 alpha,6 beta,7 beta-trihydroxy-5 beta-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat.
Journal of lipid research 2004;45(3):567-73.
2003: Alan F Hofmann
Inappropriate ileal conservation of bile acids in cholestatic liver disease: homeostasis gone awry.
Gut 2003;52(9):1239-41.
2003: T Goto; F Holzinger; lee hagey; C Cerrè; Huong-Thu Ton-Nu; Claudio D Schteingart; Joseph H Steinbach; B L Shneider; Alan F Hofmann
Physicochemical and physiological properties of 5alpha-cyprinol sulfate, the toxic bile salt of cyprinid fish.
Journal of lipid research 2003;44(9):1643-51.
2003: Jack L Porter; John S Fordtran; Carol A Santa Ana; Michael Emmett; lee hagey; Edith A Macdonald; Alan F Hofmann
Accurate enzymatic measurement of fecal bile acids in patients with malabsorption.
The Journal of laboratory and clinical medicine 2003;141(6):411-8.
2003: Vicente Lorenzo-Zúñiga; Ramón Bartolí; Ramon Planas; Alan F Hofmann; Belén Viñado; lee hagey; José M Hernández; Josep Mañé; Marco Antonio Alvarez; Vicenç Ausina; Miquel A Gassull
Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats.
Hepatology (Baltimore, Md.) 2003;37(3):551-7.
2003: Nina Zeh; Steven S Rossi; Alan F Hofmann; Joseph H Steinbach; lee hagey; Deanna Oliver; Jan Stange; Tarek I Hassanein
The effect of extracorporeal albumin dialysis on plasma phospholipid fatty acids in patients with end-stage liver disease.
Liver international : official journal of the International Association for the Study of the Liver 2003;23 Suppl 3():34-8.
2003: Michael Emmett; Michael J Guirl; Carol A Santa Ana; Jack L Porter; Sidney Neimark; Alan F Hofmann; John S Fordtran
Conjugated bile acid replacement therapy reduces urinary oxalate excretion in short bowel syndrome.
American journal of kidney diseases : the official journal of the National Kidney Foundation 2003;41(1):230-7.
2002: Takashi Iida; Masahiro Hikosaka; Genta Kakiyama; Keisuke Shiraishi; Claudio D Schteingart; lee hagey; Huong-Thu Ton-Nu; Alan F Hofmann; Nariyasu Mano; Junichi Goto; Toshio Nambara
Potential bile acid metabolites. 25. Synthesis and chemical properties of stereoisomeric 3alpha,7alpha,16- and 3alpha,7alpha,15-trihydroxy-5beta-cholan-24-oic acids.
Chemical & pharmaceutical bulletin 2002;50(10):1327-34.
2002: lee hagey; Claudio D Schteingart; Huong-Thu Ton-Nu; Alan F Hofmann
A novel primary bile acid in the Shoebill stork and herons and its phylogenetic significance.
Journal of lipid research 2002;43(5):685-90.
2002: Alan F Hofmann
Cholestatic liver disease: pathophysiology and therapeutic options.
Liver 2002;22 Suppl 2():14-9.
2001: F Holzinger; Lukas Krähenbühl; Claudio D Schteingart; Huong-Thu Ton-Nu; Alan F Hofmann
Use of a fluorescent bile acid to enhance visualization of the biliary tract and bile leaks during laparoscopic surgery in rabbits.
Surgical endoscopy 2001;15(2):209-12.
1999: Alan F Hofmann
The continuing importance of bile acids in liver and intestinal disease.
Archives of internal medicine 1999;159(22):2647-58.
1999: Ulrich Bolder; N V Trang; lee hagey; Claudio D Schteingart; Huong-Thu Ton-Nu; C Cerrè; R P Elferink; Alan F Hofmann
Sulindac is excreted into bile by a canalicular bile salt pump and undergoes a cholehepatic circulation in rats.
Gastroenterology 1999;117(4):962-71.
1999: C Gruy-Kapral; K H Little; John S Fordtran; T L Meziere; lee hagey; Alan F Hofmann
Conjugated bile acid replacement therapy for short-bowel syndrome.
Gastroenterology 1999;116(1):15-21.
1998: Alan F Hofmann
Progress in idiopathic bile acid malabsorption.
Gut 1998;43(6):738-9.
1998: lee hagey; Claudio D Schteingart; S S Rossi; Huong-Thu Ton-Nu; Alan F Hofmann
An N-acyl glycyltaurine conjugate of deoxycholic acid in the biliary bile acids of the rabbit.
Journal of lipid research 1998;39(11):2119-24.
1998: Keith D Lindor; M A Lacerda; Roberta Jorgensen; CK DeSotel; A K Batta; G Salen; E Rolland Dickson; S S Rossi; Alan F Hofmann
Relationship between biliary and serum bile acids and response to ursodeoxycholic acid in patients with primary biliary cirrhosis.
The American journal of gastroenterology 1998;93(9):1498-504.
1998: F Holzinger; Claudio D Schteingart; Huong-Thu Ton-Nu; C Cerrè; Joseph H Steinbach; H Z Yeh; Alan F Hofmann
Transport of fluorescent bile acids by the isolated perfused rat liver: kinetics, sequestration, and mobilization.
Hepatology (Baltimore, Md.) 1998;28(2):510-20.
1998: P Ricci; Alan F Hofmann; lee hagey; Roberta Jorgensen; E Rolland Dickson; Keith D Lindor
Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis.
Digestive diseases and sciences 1998;43(6):1292-5.
1998: A Venkataramani; R M Strong; D S Anderson; I T Gilmore; K Stokes; Alan F Hofmann
Abnormal duodenal bile composition in patients with acalculous chronic cholecystitis.
The American journal of gastroenterology 1998;93(3):434-41.
1998: A Schroeder; U Eckhardt; Bruno Stieger; R Tynes; Claudio D Schteingart; Alan F Hofmann; Peter J Meier Abt; Bruno Hagenbuch
Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells.
The American journal of physiology 1998;274(2 Pt 1):G370-5.
1998: Marco J Bruno; J J Borm; Frans J Hoek; B Delzenne; Alan F Hofmann; J J de Goeij; E A van Royen; DJ van Leeuwen; G N J Tytgat
Gastric transit and pharmacodynamics of a two-millimeter enteric-coated pancreatin microsphere preparation in patients with chronic pancreatitis.
Digestive diseases and sciences 1998;43(1):203-13.
1997: F Holzinger; Claudio D Schteingart; Huong-Thu Ton-Nu; S A Eming; M J Monte; lee hagey; Alan F Hofmann
Fluorescent bile acid derivatives: relationship between chemical structure and hepatic and intestinal transport in the rat.
Hepatology (Baltimore, Md.) 1997;26(5):1263-71.
1997: Siddhartha Das; Claudio D Schteingart; Alan F Hofmann; David Reiner; Stephen B Aley; Frances D Gillin
Giardia lamblia: evidence for carrier-mediated uptake and release of conjugated bile acids.
Experimental parasitology 1997;87(2):133-41.
1997: H Z Yeh; Claudio D Schteingart; lee hagey; Huong-Thu Ton-Nu; Ulrich Bolder; M A Gavrilkina; Joseph H Steinbach; Alan F Hofmann
Effect of side chain length on biotransformation, hepatic transport, and choleretic properties of chenodeoxycholyl homologues in the rodent: studies with dinorchenodeoxycholic acid, norchenodeoxycholic acid, and chenodeoxycholic acid.
Hepatology (Baltimore, Md.) 1997;26(2):374-85.
1997: Marco J Bruno; J J Borm; Frans J Hoek; B Delzenne; Alan F Hofmann; J J de Goeij; E A van Royen; Thomas M van Gulik; Laurens Th de Wit; Dirk J Gouma; DJ van Leeuwen; G N J Tytgat
Comparative effects of enteric-coated pancreatin microsphere therapy after conventional and pylorus-preserving pancreatoduodenectomy.
The British journal of surgery 1997;84(7):952-6.
1997: Alan F Hofmann
American Gastroenterological Association. Gallstone disease: physicochemical research joins empirical surgery.
Gastroenterology 1997;113(1):341-4.
1997: Antonio Benedetti; Antonio Di Sario; Luca Marucci; Gianluca Svegliati-Baroni; Claudio D Schteingart; Huong-Thu Ton-Nu; Alan F Hofmann
Carrier-mediated transport of conjugated bile acids across the basolateral membrane of biliary epithelial cells.
The American journal of physiology 1997;272(6 Pt 1):G1416-24.
1997: Alan F Hofmann; A Amelsberg; Oliver Esch; Claudio D Schteingart; KD Lyche; H Jinich; Eric vanSonnenberg; HB D'Agostino
Successful topical dissolution of cholesterol gallbladder stones using ethyl propionate.
Digestive diseases and sciences 1997;42(6):1274-82.
1997: P Brissot; Ulrich Bolder; Claudio D Schteingart; J Arnaud; Alan F Hofmann
Intestinal absorption and enterohepatic cycling of biliary iron originating from plasma non-transferrin-bound iron in rats.
Hepatology (Baltimore, Md.) 1997;25(6):1457-61.
1997: A Amelsberg; Claudio D Schteingart; J Stein; W J Simmonds; GA Sawada; Norman F H Ho; Alan F Hofmann
Intestinal absorption of sodium dodecyl sulfate in the rodent: evidence for paracellular absorption.
The American journal of physiology 1997;272(3 Pt 1):G498-506.
1997: Alan F Hofmann
Biliary secretion: future perspectives.
Digestion 1997;58 Suppl 1():24-8.
1997: Ulrich Bolder; Huong-Thu Ton-Nu; Claudio D Schteingart; E Frick; Alan F Hofmann
Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion.
Gastroenterology 1997;112(1):214-25.
1996: A Amelsberg; Claudio D Schteingart; Huong-Thu Ton-Nu; Alan F Hofmann
Carrier-mediated jejunal absorption of conjugated bile acids in the guinea pig.
Gastroenterology 1996;110(4):1098-106.
1996: William C Duane; Claudio D Schteingart; Huong-Thu Ton-Nu; Alan F Hofmann
Validation of [22,23-3H]cholic acid as a stable tracer through conversion to deoxycholic acid in human subjects.
Journal of lipid research 1996;37(2):431-6.
1996: J R Merrill; Claudio D Schteingart; lee hagey; Y Peng; Huong-Thu Ton-Nu; E Frick; M Jirsa; Alan F Hofmann
Hepatic biotransformation in rodents and physicochemical properties of 23(R)-hydroxychenodeoxycholic acid, a natural alpha-hydroxy bile acid.
Journal of lipid research 1996;37(1):98-112.
1995: S Del Vecchio; J Donald Ostrow; P Mukerjee; Huong-Thu Ton-Nu; Claudio D Schteingart; Alan F Hofmann; C Cerrè; A Roda
Method for removal of surface-active impurities and calcium from conjugated bile salt preparations: comparison with silicic acid chromatography.
Journal of lipid research 1995;36(12):2639-50.
1995: Keith D Lindor; E Rolland Dickson; Roberta Jorgensen; M L Anderson; Russell H Wiesner; G J Gores; S M Lange; S S Rossi; Alan F Hofmann; W P Baldus
The combination of ursodeoxycholic acid and methotrexate for patients with primary biliary cirrhosis: the results of a pilot study.
Hepatology (Baltimore, Md.) 1995;22(4 Pt 1):1158-62.
1995: L M Maglova; A M Jackson; X J Meng; M W Carruth; Claudio D Schteingart; Huong-Thu Ton-Nu; Alan F Hofmann; Steven Weinman
Transport characteristics of three fluorescent conjugated bile acid analogs in isolated rat hepatocytes and couplets.
Hepatology (Baltimore, Md.) 1995;22(2):637-47.
1995: C M Gelbmann; Claudio D Schteingart; S M Thompson; Alan F Hofmann; Kim E Barrett
Mast cells and histamine contribute to bile acid-stimulated secretion in the mouse colon.
The Journal of clinical investigation 1995;95(6):2831-9.
1995: Roberta Jorgensen; E Rolland Dickson; Alan F Hofmann; S S Rossi; Keith D Lindor
Characterisation of patients with a complete biochemical response to ursodeoxycholic acid.
Gut 1995;36(6):935-8.
1995: Alan F Hofmann
Defective biliary secretion during total parenteral nutrition: probable mechanisms and possible solutions.
Journal of pediatric gastroenterology and nutrition 1995;20(4):376-90.
1995: Marco J Bruno; F J Hoek; B Delzenne; D J van Leeuwen; C D Schteingart; Alan F Hofmann; G N J Tytgat
Simultaneous assessments of exocrine pancreatic function by cholesteryl-[14C]octanoate breath test and measurement of plasma p-aminobenzoic acid.
Clinical chemistry 1995;41(4):599-604.
1994: lee hagey; Claudio D Schteingart; Huong-Thu Ton-Nu; Alan F Hofmann
Biliary bile acids of fruit pigeons and doves (Columbiformes): presence of 1-beta-hydroxychenodeoxycholic acid and conjugation with glycine as well as taurine.
Journal of lipid research 1994;35(11):2041-8.
1994: J Ko; James A Hamilton; Huong-Thu Ton-Nu; Claudio D Schteingart; Alan F Hofmann; Donald M Small
Effects of side chain length on ionization behavior and transbilayer transport of unconjugated dihydroxy bile acids: a comparison of nor-chenodeoxycholic acid and chenodeoxycholic acid.
Journal of lipid research 1994;35(5):883-92.
1994: Alan F Hofmann
Pharmacology of ursodeoxycholic acid, an enterohepatic drug.
Scandinavian journal of gastroenterology. Supplement 1994;204():1-15.
1993: lee hagey; D L Crombie; E Espinosa; M C Carey; H Igimi; Alan F Hofmann
Ursodeoxycholic acid in the Ursidae: biliary bile acids of bears, pandas, and related carnivores.
Journal of lipid research 1993;34(11):1911-7.
1993: Oliver Esch; Claudio D Schteingart; Dirk Pappert; D Kirby; R Streich; Alan F Hofmann
Increased blood levels of methyl tert-butyl ether but not of ethyl propionate during instillation with contact gallstone dissolution agents in the pig.
Hepatology (Baltimore, Md.) 1993;18(2):373-9.
1993: R Todd Stravitz; Phillip B Hylemon; Douglas M Heuman; lee hagey; Claudio D Schteingart; Huong-Thu Ton-Nu; Alan F Hofmann; Z Reno Vlahcevic
Transcriptional regulation of cholesterol 7 alpha-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes.
The Journal of biological chemistry 1993;268(19):13987-93.
1993: C Wolpers; Alan F Hofmann
Solitary versus multiple cholesterol gallbladder stones. Mechanisms of formation and growth.
The Clinical investigator 1993;71(6):423-34.
1993: Claudio D Schteingart; lee hagey; K D Setchell; Alan F Hofmann
5 beta-hydroxylation by the liver. Identification of 3,5,7-trihydroxy nor-bile acids as new major biotransformation products of 3,7-dihydroxy nor-bile acids in rodents.
The Journal of biological chemistry 1993;268(15):11239-46.
1993: Alan F Hofmann
Primary and secondary prevention of gallstone disease: implications for patient management and research priorities.
American journal of surgery 1993;165(4):541-8.
1993: Adrian Schmassmann; H F Fehr; J Locher; J Lillienau; Claudio D Schteingart; S S Rossi; Alan F Hofmann
Cholylsarcosine, a new bile acid analogue: metabolism and effect on biliary secretion in humans.
Gastroenterology 1993;104(4):1171-81.
1993: J Lillienau; D L Crombie; J Munoz; S J Longmire-Cook; lee hagey; Alan F Hofmann
Negative feedback regulation of the ileal bile acid transport system in rodents.
Gastroenterology 1993;104(1):38-46.
1992: Oliver Esch; J C Spinosa; R L Hamilton; D L Crombie; Claudio D Schteingart; J F Rondinone; HB D'Agostino; J Lillienau; Alan F Hofmann
Acute effects of topical methyl tert-butyl ether or ethyl propionate on gallbladder histology in animals: a comparison of two solvents for contact dissolution of cholesterol gallstones.
Hepatology (Baltimore, Md.) 1992;16(4):984-91.
1992: S Sorscher; J Lillienau; Judy L Meinkoth; Joseph H Steinbach; Claudio D Schteingart; James R Feramisco; Alan F Hofmann
Conjugated bile acid uptake by Xenopus laevis oocytes induced by microinjection with ileal Poly A+ mRNA.
Biochemical and biophysical research communications 1992;186(3):1455-62.
1992: S J Longmire-Cook; J Lillienau; Young S Kim; Claudio D Schteingart; R G Danzinger; Oliver Esch; Alan F Hofmann
Effect of replacement therapy with cholylsarcosine on fat malabsorption associated with severe bile acid malabsorption. Studies in dogs with ileal resection.
Digestive diseases and sciences 1992;37(8):1217-27.
1992: J J Gu; Alan F Hofmann; Huong-Thu Ton-Nu; Claudio D Schteingart; K J Mysels
Solubility of calcium salts of unconjugated and conjugated natural bile acids.
Journal of lipid research 1992;33(5):635-46.
1992: Alan F Hofmann; K J Mysels
Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions.
Journal of lipid research 1992;33(5):617-26.
1992: Alan F Hofmann; J Sjövall; G Kurz; A Radominska; Claudio D Schteingart; Stephen G Tint; Z Reno Vlahcevic; K D Setchell
A proposed nomenclature for bile acids.
Journal of lipid research 1992;33(4):599-604.
1992: M Lira; Claudio D Schteingart; Joseph H Steinbach; K Lambert; J A McRoberts; Alan F Hofmann
Sugar absorption by the biliary ductular epithelium of the rat: evidence for two transport systems.
Gastroenterology 1992;102(2):563-71.
1992: J Lillienau; Claudio D Schteingart; Alan F Hofmann
Physicochemical and physiological properties of cholylsarcosine. A potential replacement detergent for bile acid deficiency states in the small intestine.
The Journal of clinical investigation 1992;89(2):420-31.
1991: M Yoshii; E H Mosbach; Claudio D Schteingart; lee hagey; Alan F Hofmann; Bertram Cohen; C K McSherry
Chemical synthesis and hepatic biotransformation of 3 alpha,7 alpha-dihydroxy-7 beta-methyl-24-nor-5 beta-cholan-23-oic acid, a 7-methyl derivative of norchenodeoxycholic acid: studies in the hamster.
Journal of lipid research 1991;32(11):1729-40.
1991: R L Fisher; Alan F Hofmann; J L Converse; S S Rossi; S P Lan
The lack of relationship between hepatotoxicity and lithocholic-acid sulfation in biliary bile acids during chenodiol therapy in the National Cooperative Gallstone Study.
Hepatology (Baltimore, Md.) 1991;14(3):454-63.
1991: R G Quist; Huong-Thu Ton-Nu; J Lillienau; Alan F Hofmann; Kim E Barrett
Activation of mast cells by bile acids.
Gastroenterology 1991;101(2):446-56.
1991: Bertram Cohen; N Ayyad; E H Mosbach; C K McSherry; N Matoba; Alan F Hofmann; Huong-Thu Ton-Nu; Y Peng; Claudio D Schteingart; R J Stenger
Replacement of cholesterol gallstones by murideoxycholyl taurine gallstones in prairie dogs fed murideoxycholic acid.
Hepatology (Baltimore, Md.) 1991;14(1):158-68.
1991: HB D'Agostino; Eric vanSonnenberg; Claudio D Schteingart; Alan F Hofmann; Giovanna Casola; J R Mathieson
Thin-layer chromatography to monitor cholesterol gallstone dissolution by methyl tert-butyl ether.
AJR. American journal of roentgenology 1991;157(1):33-6.
1991: Eric vanSonnenberg; HB D'Agostino; Alan F Hofmann; R B Sanchez; Brian W Goodacre; Oliver Esch; Giovanna Casola
Percutaneous dissolution of gallstones.
Seminars in roentgenology 1991;26(3):251-8.
1991: Alan F Hofmann; Theodore M Bayless; D H Alpers
Undergraduate teaching project of the American gastroenterological Association: a pathophysiology resource.
The American journal of physiology 1991;260(6 Pt 3):S1-5.
1991: Alan F Hofmann; Claudio D Schteingart; J Lillienau
Biological and medical aspects of active ileal transport of bile acids.
Annals of medicine 1991;23(2):169-75.
1991: Alan F Hofmann; Claudio D Schteingart; Eric vanSonnenberg; Oliver Esch; S F Zakko
Contact dissolution of cholesterol gallstones with organic solvents.
Gastroenterology clinics of North America 1991;20(1):183-99.
1991: D Gurantz; Claudio D Schteingart; lee hagey; Joseph H Steinbach; T Grotmol; Alan F Hofmann
Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids.
Hepatology (Baltimore, Md.) 1991;13(3):540-50.
1991: Ronald P J Oude Elferink; Roelof Ottenhoff; A Radominska; Alan F Hofmann; Folkert Kuipers; Peter L M Jansen
Inhibition of glutathione-conjugate secretion from isolated hepatocytes by dipolar bile acids and other organic anions.
The Biochemical journal 1991;274 ( Pt 1)():281-6.
1991: S N Marcus; Claudio D Schteingart; M L Marquez; Alan F Hofmann; Y Xia; Joseph H Steinbach; Huong-Thu Ton-Nu; J Lillienau; M A Angellotti; Adrian Schmassmann
Active absorption of conjugated bile acids in vivo. Kinetic parameters and molecular specificity of the ileal transport system in the rat.
Gastroenterology 1991;100(1):212-21.
1990: Adrian Schmassmann; M A Angellotti; C Clerici; Alan F Hofmann; Huong-Thu Ton-Nu; Claudio D Schteingart; S N Marcus; lee hagey; S S Rossi; A Aigner
Transport, metabolism, and effect of chronic feeding of lagodeoxycholic acid. A new, natural bile acid.
Gastroenterology 1990;99(4):1092-104.
1990: Alan F Hofmann
Bile acid secretion, bile flow and biliary lipid secretion in humans.
Hepatology (Baltimore, Md.) 1990;12(3 Pt 2):17S-22S; discussion 22S-25S.
1990: Y Xia; K J Lambert; Claudio D Schteingart; J J GU; Alan F Hofmann
Concentrative biliary secretion of ceftriaxone. Inhibition of lipid secretion and precipitation of calcium ceftriaxone in bile.
Gastroenterology 1990;99(2):454-65.
1990: Adrian Schmassmann; Alan F Hofmann; M A Angellotti; Huong-Thu Ton-Nu; Claudio D Schteingart; C Clerici; S S Rossi; M A Rothschild; Bertram Cohen; R J Stenger
Prevention of ursodeoxycholate hepatotoxicity in the rabbit by conjugation with N-methyl amino acids.
Hepatology (Baltimore, Md.) 1990;11(6):989-96.
1990: S F Zakko; Alan F Hofmann
Microprocessor-assisted solvent transfer system for effective contact dissolution of gallbladder stones.
IEEE transactions on bio-medical engineering 1990;37(4):410-6.
1990: Alan F Hofmann
Nonsurgical treatment of gallstone disease.
Annual review of medicine 1990;41():401-15.
1990: Adrian Schmassmann; M A Angellotti; Huong-Thu Ton-Nu; Claudio D Schteingart; S N Marcus; S S Rossi; Alan F Hofmann
Transport, metabolism, and effect of chronic feeding of cholylsarcosine, a conjugated bile acid resistant to deconjugation and dehydroxylation.
Gastroenterology 1990;98(1):163-74.
1989: Alan F Hofmann
Current concepts of biliary secretion.
Digestive diseases and sciences 1989;34(12 Suppl):16S-20S.
1989: Alan F Hofmann
Medical dissolution of gallstones by oral bile acid therapy.
American journal of surgery 1989;158(3):198-204.
1989: R P Oude Elferink; J de Haan; K J Lambert; lee hagey; Alan F Hofmann; P L Jansen
Selective hepatobiliary transport of nordeoxycholate side chain conjugates in mutant rats with a canalicular transport defect.
Hepatology (Baltimore, Md.) 1989;9(6):861-5.
1989: L M Clayton; D Gurantz; Alan F Hofmann; lee hagey; Claudio D Schteingart
Role of bile acid conjugation in hepatic transport of dihydroxy bile acids.
The Journal of pharmacology and experimental therapeutics 1989;248(3):1130-7.
1989: Eric vanSonnenberg; Giovanna Casola; R R Varney; S Zakko; Gerhard R Wittich; J Cox; Alan F Hofmann
Interventional radiology in the gallbladder.
Radiographics : a review publication of the Radiological Society of North America, Inc 1989;9(1):39-49.
1988: Eric vanSonnenberg; Giovanna Casola; S F Zakko; R R Varney; J Cox; Gerhard R Wittich; Alan F Hofmann
Gallbladder and bile duct stones: percutaneous therapy with primary MTBE dissolution and mechanical methods.
Radiology 1988;169(2):505-9.
1988: Claudio D Schteingart; Alan F Hofmann
Synthesis of 24-nor-5 beta-cholan-23-oic acid derivatives: a convenient and efficient one-carbon degradation of the side chain of natural bile acids.
Journal of lipid research 1988;29(10):1387-95.
1988: Alan F Hofmann; B Strandvik
Defective bile acid amidation: predicted features of a new inborn error of metabolism.
Lancet 1988;2(8606):311-3.
1988: John R Lake; E L Renner; Bruce F Scharschmidt; E J Cragoe; lee hagey; K J Lambert; D Gurantz; Alan F Hofmann
Inhibition of Na+/H+ exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated urodeoxycholate, and increased ursodeoxycholate glucuronidation.
Gastroenterology 1988;95(2):454-63.
1988: Alan F Hofmann
Walter B. Cannon lecture. Bile, bile acids, and gallstones: will new knowledge bring new power?
AJR. American journal of roentgenology 1988;151(1):5-12.
1988: S Kuroki; Claudio D Schteingart; lee hagey; Bertram Cohen; E H Mosbach; S S Rossi; Alan F Hofmann; N Matoba; M Une; T Hoshita
Bile salts of the West Indian manatee, Trichechus manatus latirostris: novel bile alcohol sulfates and absence of bile acids.
Journal of lipid research 1988;29(4):509-22.
1988: Eric vanSonnenberg; Alan F Hofmann
Horizons in gallstone therapy--1988.
AJR. American journal of roentgenology 1988;150(1):43-6.
1987: S G Cole; S Rossi; A Stern; Alan F Hofmann
Cholesteryl octanoate breath test. Preliminary studies on a new noninvasive test of human pancreatic exocrine function.
Gastroenterology 1987;93(6):1372-80.
1987: Stefan Mundlos; J B Rhodes; Alan F Hofmann
The cholesteryl octanoate breath test: a new procedure for detection of pancreatic insufficiency in the rat.
Pediatric research 1987;22(3):257-61.
1987: K R Palmer; D Gurantz; Alan F Hofmann; L M Clayton; lee hagey; S Cecchetti
Hypercholeresis induced by norchenodeoxycholate in biliary fistula rodent.
The American journal of physiology 1987;252(2 Pt 1):G219-28.
1986: Bertram Cohen; Alan F Hofmann; E H Mosbach; R J Stenger; M A Rothschild; lee hagey; Y B Yoon
Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit.
Gastroenterology 1986;91(1):189-97.
1986: Y B Yoon; lee hagey; Alan F Hofmann; D Gurantz; Enrique Michelotti; Joseph H Steinbach
Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents.
Gastroenterology 1986;90(4):837-52.
1984: J W Marks; G Croke; N Gochman; Alan F Hofmann; J M Lachin; L J Schoenfield; M P Tyor; T Hersh; N C Hightower; Elliott Charles Lasser
Major issues in the organization and implementation of the National Cooperative Gallstone Study (NCGS).
Controlled clinical trials 1984;5(1):1-12.
1984: J W Marks; S P Lan; R A Baum; R L Habig; R F Hanson; T Hersh; N C Hightower; Alan F Hofmann; J M Lachin; Elliott Charles Lasser
Low-dose chenodiol to prevent gallstone recurrence after dissolution therapy.
Annals of internal medicine 1984;100(3):376-81.
1983: L J Schoenfield; S M Grundy; Alan F Hofmann; J M Lachin; J L Thistle; M P Tyor
The National Cooperative Gallstone Study viewed by its investigators.
Gastroenterology 1983;84(3):644-8.
1982: G B Davis; R N Berk; F W Scheible; K F Witztum; I T Gilmore; R M Strong; Alan F Hofmann
Cholecystokinin cholecystography, sonography, and scintigraphy: detection of chronic acalculous cholecystitis.
AJR. American journal of roentgenology 1982;139(6):1117-21.
1982: Alan F Hofmann; S M Grundy; J M Lachin; S P Lan; R A Baum; R F Hanson; T Hersh; N C Hightower; J W Marks; H Mekhjian; R A Shaefer; R D Soloway; J L Thistle; F B Thomas; M P Tyor
Pretreatment biliary lipid composition in white patients with radiolucent gallstones in the National Cooperative Gallstone Study.
Gastroenterology 1982;83(4):738-52.