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Franz Hofmann

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Sabine Klein; Roland Rad; Michael Rohn; Hans-Dieter Allescher; Robert Feil; Franz Hofmann; Anna Kettenberger; Michael Schemann; Roland M Schmid; Günter Schneider; Barbara Seidler; Andrei Sibaev; Martin Storr; Jean-Marie Vanderwinden; Dieter Saur
Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity.
Julia Brandmayr; Jie Ding; Katrin Domes; Sven Moosmang; Montatip Poomvanicha; Jörg W Wegener; Anne Blaich; Franz Hofmann
Deletion of the C-terminal phosphorylation sites in the cardiac β-subunit does not affect the basic β-adrenergic response of the heart and the Ca(v)1.2 channel.
Anne Blaich; Katrin Domes; Peter Lenhardt; Peter Lipp; Sven Moosmang; Martin Oberhofer; Sara Pahlavan; Montatip Poomvanicha; Sandra Ruppenthal; Anke Scholz; Qinghai Tian; Jörg W Wegener; Franz Hofmann
Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death.

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All Publications

2013: Sabine Klein; Roland Rad; Michael Rohn; Hans-Dieter Allescher; Robert Feil; Franz Hofmann; Anna Kettenberger; Michael Schemann; Roland M Schmid; Günter Schneider; Barbara Seidler; Andrei Sibaev; Martin Storr; Jean-Marie Vanderwinden; Dieter Saur
Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity.
Nature communications 2013;4():1630.
2012: Julia Brandmayr; Jie Ding; Katrin Domes; Sven Moosmang; Montatip Poomvanicha; Jörg W Wegener; Anne Blaich; Franz Hofmann
Deletion of the C-terminal phosphorylation sites in the cardiac β-subunit does not affect the basic β-adrenergic response of the heart and the Ca(v)1.2 channel.
The Journal of biological chemistry 2012;287(27):22584-92.
2012: Anne Blaich; Katrin Domes; Peter Lenhardt; Peter Lipp; Sven Moosmang; Martin Oberhofer; Sara Pahlavan; Montatip Poomvanicha; Sandra Ruppenthal; Anke Scholz; Qinghai Tian; Jörg W Wegener; Franz Hofmann
Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death.
The Journal of biological chemistry 2012;287(27):22616-25.
2012: Anurag Kumar Singh; Beate Spiessberger; Jörg W Wegener; Pascal Weinmeister; Fang Xiao; Wen Zheng; Sabine Klein; Dagmar Krueger; Robert Lukowski; Dieter Saur; Michael Schemann; Ursula Seidler; Franz Hofmann
Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(4):1745-54.
2011: Alexander von Werder; Hans-Dieter Allescher; Ralph Fritsch; Franz Hofmann; Martina Mayr; Daniela Oesterle; Michael Schemann; Jens Schlossmann; Roland M Schmid; Günter Schneider; Barbara Seidler; Dieter Saur
Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction.
American journal of physiology. Cell physiology 2011;301(6):C1445-57.
2011: Claudia Ertl; Franz Hofmann; Robert Lukowski; Jens Schlossmann; Katja Sigl; Jörg W Wegener
Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle.
European journal of pharmacology 2011;670(1):266-71.
2011: Stefanie Fenske; Franz Hofmann; Robert Mader; Stylianos Michalakis; Christos Paparizos; Andreas Scharr; Lior Shaltiel; Juliane Stieber; Christian Wahl-Schott; Martha Weidinger; Xiaochun Cao-Ehlker; Robert Feil; Susanne Feil; Martin Biel
HCN3 contributes to the ventricular action potential waveform in the murine heart.
Circulation research 2011;109(9):1015-23.
2011: Katrin Domes; Anne Blaich; Julia Brandmayr; Jie Ding; Toni Lemke; Sven Moosmang; Jörg W Wegener; Franz Hofmann
Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.
The Journal of biological chemistry 2011;286(39):33863-71.
2011: Montatip Poomvanicha; Jörg W Wegener; Sven Moosmang; Anne Blaich; Katrin Domes; Stefanie Fischer; Franz Hofmann
Facilitation and Ca2+-dependent inactivation are modified by mutation of the Ca(v)1.2 channel IQ motif.
The Journal of biological chemistry 2011;286(30):26702-7.
2011: Lucas Matt; Stylianos Michalakis; Franz Hofmann; Verena Hammelmann; Andreas Ludwig; Martin Biel; Thomas Kleppisch
HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path.
Cellular and molecular life sciences : CMLS 2011;68(1):125-37.
2010: Alessandra Moretti; Milena Bellin; Andrea Welling; Christian Billy Jung; Jason T Lam; Lorenz Bott-Flügel; Tatjana Dorn; Alexander Goedel; C Höhnke; Franz Hofmann; Melchior Seyfarth; Daniel Sinnecker; Albert Schömig; Karl-Ludwig Laugwitz
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
The New England journal of medicine 2010;363(15):1397-409.
2010: Maria Huster; Eva Frei; Franz Hofmann; Jörg W Wegener
A complex of Ca(V)1.2/PKC is involved in muscarinic signaling in smooth muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(8):2651-9.
2010: Nicole Langwieser; Carl J Christel; Thomas Kleppisch; Franz Hofmann; Carsten T Wotjak; Sven Moosmang
Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(25):8367-75.
2010: Anne Blaich; Andrea Welling; Stefanie Fischer; Jörg W Wegener; Katharina Köstner; Franz Hofmann; Sven Moosmang
Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(22):10285-9.
2010: Cindy Paul; Christopher Stratil; Franz Hofmann; Thomas Kleppisch
cGMP-dependent protein kinase type I promotes CREB/CRE-mediated gene expression in neurons of the lateral amygdala.
Neuroscience letters 2010;473(2):82-6.
2010: Robert Lukowski; Sergei D Rybalkin; Florian Loga; Veronika Leiss; Joseph A Beavo; Franz Hofmann
Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(12):5646-51.
2010: Franz Hofmann
Ido brings down the pressure in systemic inflammation.
Nature medicine 2010;16(3):265-7.
2009: Naoki Sawada; Hiroshi Itoh; Kazutoshi Miyashita; Hirokazu Tsujimoto; Masakatsu Sone; Kenichi Yamahara; Zoltan P Arany; Franz Hofmann; Kazuwa Nakao
Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels.
Molecular and cellular biology 2009;29(22):6018-32.
2009: Eva Frei; Maria Huster; Petra Smital; Jens Schlossmann; Franz Hofmann; Jörg W Wegener
Calcium-dependent and calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(4):G834-9.
2009: Takahiro Higuchi; Martina Anton; Katja Dumler; Stefan Seidl; Jaroslav Pelisek; Antti Saraste; Andrea Welling; Franz Hofmann; Robert A J Oostendorp; Bernd Gansbacher; Stephan G Nekolla; Frank M Bengel; Rene M Botnar; Markus Schwaiger
Combined reporter gene PET and iron oxide MRI for monitoring survival and localization of transplanted cells in the rat heart.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009;50(7):1088-94.
2009: Eva Frei; Franz Hofmann; Jörg W Wegener
Phospholipase C mediated Ca2+ signals in murine urinary bladder smooth muscle.
European journal of pharmacology 2009;610(1-3):106-9.
2009: M V Muetzelburg; Franz Hofmann; Ingo Just; A Pich
Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(13):1344-51.
2009: Beate Spiessberger; Dominik Bernhard; Stefan Herrmann; Susanne Feil; Claudia Werner; Peter B Luppa; Franz Hofmann
cGMP-dependent protein kinase II and aldosterone secretion.
The FEBS journal 2009;276(4):1007-13.
2008: Cindy Paul; Florian Schöberl; Pascal Weinmeister; Vincenzo Micale; Carsten T Wotjak; Franz Hofmann; Thomas Kleppisch
Signaling through cGMP-dependent protein kinase I in the amygdala is critical for auditory-cued fear memory and long-term potentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(52):14202-12.
2008: Toni Lemke; Andrea Welling; Carl Johannes Christel; Anne Blaich; Dominik Bernhard; Peter Lenhardt; Franz Hofmann; Sven Moosmang
Unchanged beta-adrenergic stimulation of cardiac L-type calcium channels in Ca v 1.2 phosphorylation site S1928A mutant mice.
The Journal of biological chemistry 2008;283(50):34738-44.
2008: Pascal Weinmeister; Robert Lukowski; Stefan Linder; Claudia Traidl-Hoffmann; Ludger Hengst; Franz Hofmann; Robert Feil
Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells.
Molecular biology of the cell 2008;19(10):4434-41.
2008: Evelyn Hoesl; Juliane Stieber; Stefan Herrmann; Susanne Feil; Elisabeth Tybl; Franz Hofmann; Robert Feil; Andreas Ludwig
Tamoxifen-inducible gene deletion in the cardiac conduction system.
Journal of molecular and cellular cardiology 2008;45(1):62-9.
2008: Robert Lukowski; Pascal Weinmeister; Dominik Bernhard; Susanne Feil; Michael Gotthardt; Joachim Herz; Steffen Massberg; Alma Zernecke; Christian Weber; Franz Hofmann; Robert Feil
Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1244-50.
2008: Michael Föller; Susanne Feil; Kamran Ghoreschi; Saisudha Koka; Andrea Gerling; Martin Thunemann; Franz Hofmann; Beat Schuler; Johannes Vogel; Bernd J Pichler; Ravi S Kasinathan; Jan P Nicolay; Stephan M Huber; Florian Lang; Robert Feil
Anemia and splenomegaly in cGKI-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6771-6.
2008: Achim Schmidtko; Wei Gao; Matthias Sausbier; Inga Rauhmeier; Ulrike Sausbier; Ellen Niederberger; Klaus Scholich; Andrea Huber; Winfried Neuhuber; Hans-Dieter Allescher; Franz Hofmann; Irmgard Tegeder; Peter Ruth; Gerd Geisslinger
Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(6):1320-30.
2008: Lubica Lacinova; Sven Moosmang; Nicole Langwieser; Franz Hofmann; Thomas Kleppisch
Cav1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells.
Life sciences 2008;82(1-2):41-9.
2007: Silke Weber; Dominik Bernhard; Robert Lukowski; Pascal Weinmeister; René Wörner; Jörg W Wegener; Nadejda Valtcheva; Susanne Feil; Jens Schlossmann; Franz Hofmann; Robert Feil
Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme.
Circulation research 2007;101(11):1096-103.
2007: Stefan Herrmann; Juliane Stieber; Georg Stöckl; Franz Hofmann; Andreas Ludwig
HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.
The EMBO journal 2007;26(21):4423-32.
2007: Hannes Schmidt; Agne Stonkute; René Jüttner; Susanne Schäffer; Jens Buttgereit; Robert Feil; Franz Hofmann; Fritz G Rathjen
The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.
The Journal of cell biology 2007;179(2):331-40.
2007: Kirill Essin; Andrea Welling; Franz Hofmann; Friedrich C Luft; Maik Gollasch; Sven Moosmang
Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells.
The Journal of physiology 2007;584(Pt 1):205-19.
2007: Sabine Conrad; Harald Genth; Franz Hofmann; Ingo Just; Thomas Skutella
Neogenin-RGMa signaling at the growth cone is bone morphogenetic protein-independent and involves RhoA, ROCK, and PKC.
The Journal of biological chemistry 2007;282(22):16423-33.
2007: Matthias Sausbier; Xiao-Bo Zhou; Caroline Beier; Ulrike Sausbier; Daniela Wolpers; Sylvi Maget; Christian Martin; Alexander Dietrich; Anna-Rebekka Ressmeyer; Harald Renz; Jens Schlossmann; Franz Hofmann; Winfried Neuhuber; Thomas Gudermann; Stefan Uhlig; Michael Korth; Peter Ruth
Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+-activated K+ channel.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(3):812-22.
2007: Melanie Antl; Marie-Luise von Brühl; Christina Eiglsperger; Matthias Werner; Ildiko Konrad; Thomas Kocher; Matthias Wilm; Franz Hofmann; Steffen Massberg; Jens Schlossmann
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.
Blood 2007;109(2):552-9.
2007: Sven Moosmang; Thomas Kleppisch; Jörg W Wegener; Andrea Welling; Franz Hofmann
Analysis of calcium channels by conditional mutagenesis.
Handbook of experimental pharmacology 2007;(178):469-90.
2007: René Wörner; Robert Lukowski; Franz Hofmann; Jörg W Wegener
cGMP signals mainly through cAMP kinase in permeabilized murine aorta.
American journal of physiology. Heart and circulatory physiology 2007;292(1):H237-44.
2006: Beate Fiedler; Robert Feil; Franz Hofmann; Christian Willenbockel; Helmut Drexler; Albert Smolenski; Suzanne M Lohmann; Kai C Wollert
cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes.
The Journal of biological chemistry 2006;281(43):32831-40.
2006: Tae-Seong Lee; Rosi Karl; Sven Moosmang; Peter Lenhardt; Norbert Klugbauer; Franz Hofmann; Thomas Kleppisch; Andrea Welling
Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites.
The Journal of biological chemistry 2006;281(35):25560-7.
2006: Sven G Meuth; Tatyana Kanyshkova; Patrick Meuth; Peter Landgraf; Thomas Munsch; Andreas Ludwig; Franz Hofmann; Hans-Christian Pape; Thomas Budde
Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels.
Journal of neurophysiology 2006;96(3):1517-29.
2006: Harald Genth; Johannes Huelsenbeck; Birgit Hartmann; Franz Hofmann; Ingo Just; Ralf Gerhard
Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B.
FEBS letters 2006;580(14):3565-9.
2006: Jörg W Wegener; Verena Schulla; Angela Koller; Norbert Klugbauer; Robert Feil; Franz Hofmann
Control of intestinal motility by the Ca(v)1.2 L-type calcium channel in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1260-2.
2006: Sheila Vignali; Veronika Leiss; Rosi Karl; Franz Hofmann; Andrea Welling
Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells.
The Journal of physiology 2006;572(Pt 3):691-706.
2006: L'ubica Lacinová; Martina Kurejová; Norbert Klugbauer; Franz Hofmann
Gating of the expressed T-type Cav3.1 calcium channels is modulated by Ca2+.
Acta physiologica (Oxford, England) 2006;186(4):249-60.
2006: Juliane Stieber; Karen Wieland; Georg Stöckl; Andreas Ludwig; Franz Hofmann
Bradycardic and proarrhythmic properties of sinus node inhibitors.
Molecular pharmacology 2006;69(4):1328-37.
2006: Sven Moosmang; Nicole Haider; Birgit Brüderl; Andrea Welling; Franz Hofmann
Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2.
Circulation research 2006;98(1):105-10.
2005: Franz Hofmann; Martin Biel; U Benjamin Kaupp
International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.
Pharmacological reviews 2005;57(4):455-62.
2005: Markus Höltje; Anja Hoffmann; Franz Hofmann; Christian Mucke; Gisela Grosse; Nico van Rooijen; Helmut Kettenmann; Ingo Just; Gudrun Ahnert-Hilger
Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing.
Journal of neurochemistry 2005;95(5):1237-48.
2005: Galina Demyanenko; Ari I Halberstadt; Katherine B Pryzwansky; Claudia Werner; Franz Hofmann; Patricia F Maness
Abnormal neocortical development in mice lacking cGMP-dependent protein kinase I.
Brain research. Developmental brain research 2005;160(1):1-8.
2005: Marcel J C Bijvelds; Huub Jorna; Henkjan J Verkade; Alice G M Bot; Franz Hofmann; Luis B Agellon; Maarten Sinaasappel; Hugo R de Jonge
Activation of CFTR by ASBT-mediated bile salt absorption.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(5):G870-9.
2005: Sven Moosmang; Nicole Haider; Norbert Klugbauer; Helmuth Adelsberger; Nicolas Langwieser; Jochen Müller; Michael Stiess; Else Marais; Verena Schulla; Lubica Lacinova; Sandra Goebbels; Klaus-Armin Nave; Daniel R Storm; Franz Hofmann; Thomas Kleppisch
Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(43):9883-92.
2005: Juliane Stieber; Georg Stöckl; Stefan Herrmann; Benjamin Hassfurth; Franz Hofmann
Functional expression of the human HCN3 channel.
The Journal of biological chemistry 2005;280(41):34635-43.
2005: Niklas Czeloth; Günter Bernhardt; Franz Hofmann; Harald Genth; Reinhold Förster
Sphingosine-1-phosphate mediates migration of mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2960-7.
2005: Claudia G Werner; Virginia L Godfrey; Roland R Arnold; Gerald L Featherstone; Diane Bender; Jens Schlossmann; Matthias Schiemann; Franz Hofmann; Katherine B Pryzwansky
Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1919-29.
2005: Matthias Sausbier; Claudia Arntz; Iancu Bucurenciu; Hong Zhao; Xiao-Bo Zhou; Ulrike Sausbier; Susanne Feil; Simone Kamm; Kirill Essin; Claudia A Sailer; Usamah Abdullah; Peter Krippeit-Drews; Robert Feil; Franz Hofmann; Hans-Günther Knaus; Chris Kenyon; Michael Shipston; Johan F Storm; Winfried Neuhuber; Michael Korth; Rudolf Schubert; Maik Gollasch; Peter Ruth
Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.
Circulation 2005;112(1):60-8.
2005: Sven Moosmang; Peter Lenhardt; Nicole Haider; Franz Hofmann; Jörg W Wegener
Mouse models to study L-type calcium channel function.
Pharmacology & therapeutics 2005;106(3):347-55.
2005: Jens Schlossmann; Franz Hofmann
cGMP-dependent protein kinases in drug discovery.
Drug discovery today 2005;10(9):627-34.
2005: L'ubica Lacinová; Franz Hofmann
Ca2+- and voltage-dependent inactivation of the expressed L-type Ca(v)1.2 calcium channel.
Archives of biochemistry and biophysics 2005;437(1):42-50.
2005: Stylianos Michalakis; Heidi Geiger; Silke Haverkamp; Franz Hofmann; Andrea Gerstner; Martin Biel
Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.
Investigative ophthalmology & visual science 2005;46(4):1516-24.
2005: Ralf Gerhard; Silke Burger; Helma Tatge; Harald Genth; Ingo Just; Franz Hofmann
Comparison of wild type with recombinant Clostridium difficile toxin A.
Microbial pathogenesis 2005;38(2-3):77-83.
2005: Robert Feil; Susanne Feil; Franz Hofmann
A heretical view on the role of NO and cGMP in vascular proliferative diseases.
Trends in molecular medicine 2005;11(2):71-5.
2005: Andrea Welling; Franz Hofmann; Jörg W Wegener
Inhibition of L-type Cav1.2 Ca2+ channels by 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Go6983).
Molecular pharmacology 2005;67(2):541-4.
2005: Franz Hofmann
The biology of cyclic GMP-dependent protein kinases.
The Journal of biological chemistry 2005;280(1):1-4.
2005: Susanne Feil; P Zimmermann; A Knorn; Sabine Brummer; Jens Schlossmann; Franz Hofmann; Robert Feil
Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina.
Neuroscience 2005;135(3):863-8.
2005: Robert Feil; Franz Hofmann; Thomas Kleppisch
Function of cGMP-dependent protein kinases in the nervous system.
Reviews in the neurosciences 2005;16(1):23-41.
2005: Jens Schlossmann; Robert Feil; Franz Hofmann
Insights into cGMP signalling derived from cGMP kinase knockout mice.
Frontiers in bioscience : a journal and virtual library 2005;10():1279-89.
2004: Claudia Werner; Gennadij Raivich; Michael S Cowen; Tatyana Strekalova; Inge Sillaber; Jeroen Buters; Rainer Spanagel; Franz Hofmann
Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol.
The European journal of neuroscience 2004;20(12):3498-506.
2004: Thorsten Walles; Bettina Giere; Michael Hofmann; Johanna Schanz; Franz Hofmann; Heike Mertsching; Paolo Macchiarini
Experimental generation of a tissue-engineered functional and vascularized trachea.
The Journal of thoracic and cardiovascular surgery 2004;128(6):900-6.
2004: Angela Geiselhöringer; Matthias Werner; Katja Sigl; Petra Smital; René Wörner; Linda Acheo; Juliane Stieber; Pascal Weinmeister; Robert Feil; Susanne Feil; Jörg W Wegener; Franz Hofmann; Jens Schlossmann
IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase.
The EMBO journal 2004;23(21):4222-31.
2004: Angela Geiselhöringer; M Gaisa; Franz Hofmann; Jens Schlossmann
Distribution of IRAG and cGKI-isoforms in murine tissues.
FEBS letters 2004;575(1-3):19-22.
2004: Gudrun Ahnert-Hilger; Markus Höltje; Gisela Grosse; G Pickert; C Mucke; B Nixdorf-Bergweiler; P Boquet; Franz Hofmann; I Just
Differential effects of Rho GTPases on axonal and dendritic development in hippocampal neurones.
Journal of neurochemistry 2004;90(1):9-18.
2004: Jörg W Wegener; Verena Schulla; Tae-Seong Lee; Angela Koller; Susanne Feil; Robert Feil; Thomas Kleppisch; Norbert Klugbauer; Sven Moosmang; Andrea Welling; Franz Hofmann
An essential role of Cav1.2 L-type calcium channel for urinary bladder function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(10):1159-61.
2004: Matthias Sausbier; Hua Hu; Claudia Arntz; Susanne Feil; Simone Kamm; H Adelsberger; Ulrike Sausbier; Claudia A Sailer; Robert Feil; Franz Hofmann; Michael Korth; Michael Shipston; Hans-Günther Knaus; D P Wolfer; Christine M Pedroarena; Johan F Storm; Peter Ruth
Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9474-8.
2004: Susanne Feil; Franz Hofmann; Robert Feil
SM22alpha modulates vascular smooth muscle cell phenotype during atherogenesis.
Circulation research 2004;94(7):863-5.
2004: Ralph Fritsch; Dieter Saur; Manfred Kurjak; Daniela Oesterle; Jens Schlossmann; Angela Geiselhöringer; Franz Hofmann; Hans-Dieter Allescher
InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle.
The Journal of biological chemistry 2004;279(13):12551-9.
2004: Irmgard Tegeder; Domenico Del Turco; Achim Schmidtko; Matthias Sausbier; Robert Feil; Franz Hofmann; Thomas Deller; Peter Ruth; Gerd Geisslinger
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3253-7.
2004: Julia Brill; Rainer Klocke; Dieter Paul; Detlev Boison; Nicolette Gouder; Norbert Klugbauer; Franz Hofmann; Cord-Michael Becker; Kristina Becker
entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.
The Journal of biological chemistry 2004;279(8):7322-30.
2004: Juliane Stieber; Franz Hofmann; Andreas Ludwig
Pacemaker channels and sinus node arrhythmia.
Trends in cardiovascular medicine 2004;14(1):23-8.
2003: Juliane Stieber; Stefan Herrmann; Susanne Feil; Jana Löster; Robert Feil; Martin Biel; Franz Hofmann; Andreas Ludwig
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(25):15235-40.
2003: Norbert Klugbauer; Else Marais; Franz Hofmann
Calcium channel alpha2delta subunits: differential expression, function, and drug binding.
Journal of bioenergetics and biomembranes 2003;35(6):639-47.
2003: Franz Hofmann; Martin Biel; U Benjamin Kaupp
International Union of Pharmacology. XLII. Compendium of voltage-gated ion channels: cyclic nucleotide-modulated channels.
Pharmacological reviews 2003;55(4):587-9.
2003: Sven Moosmang; Verena Schulla; Andrea Welling; Robert Feil; Susanne Feil; Jörg W Wegener; Franz Hofmann; Norbert Klugbauer
Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation.
The EMBO journal 2003;22(22):6027-34.
2003: Robert Feil; Suzanne M Lohmann; Hugo R de Jonge; Ulrich Walter; Franz Hofmann
Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice.
Circulation research 2003;93(10):907-16.
2003: Wiebke Wolfsgruber; Susanne Feil; Sabine Brummer; Oliver Kuppinger; Franz Hofmann; Robert Feil
A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13519-24.
2003: Robert Feil; Jana Hartmann; Chongde Luo; Wiebke Wolfsgruber; Karl Schilling; Susanne Feil; Jaroslaw Barski; Michael Meyer; Arthur Konnerth; Chris I De Zeeuw; Franz Hofmann
Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I.
The Journal of cell biology 2003;163(2):295-302.
2003: Man Xu; Andrea Welling; Susanne Paparisto; Franz Hofmann; Norbert Klugbauer
Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.
The Journal of biological chemistry 2003;278(42):40837-41.
2003: Juliane Stieber; Anna Thomer; Barbara Much; Angela Schneider; Martin Biel; Franz Hofmann
Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.
The Journal of biological chemistry 2003;278(36):33672-80.
2003: Silke Burger; Helma Tatge; Franz Hofmann; Harald Genth; Ingo Just; Ralf Gerhard
Expression of recombinant Clostridium difficile toxin A using the Bacillus megaterium system.
Biochemical and biophysical research communications 2003;307(3):584-8.
2003: Verena Schulla; Erik Renström; Robert Feil; Susanne Feil; Isobel Franklin; Asllan Gjinovci; Xing-Jun Jing; Dirk Laux; Ingmar Lundquist; Mark Magnuson; Stefanie Obermüller; Charlotta S Olofsson; Albert Salehi; Anna Wendt; Norbert Klugbauer; Claes B Wollheim; Patrik Rorsman; Franz Hofmann
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.
The EMBO journal 2003;22(15):3844-54.
2003: Arie B Vaandrager; Boris M Hogema; Marcel Edixhoven; Caroline M M van den Burg; Alice G M Bot; Peter Klatt; Peter Ruth; Franz Hofmann; Jozef Van Damme; Joel Vandekerckhove; Hugo R de Jonge
Autophosphorylation of cGMP-dependent protein kinase type II.
The Journal of biological chemistry 2003;278(31):28651-8.
2003: Masami Shimizu-Albergine; Sergei D Rybalkin; Irina G Rybalkina; Robert Feil; Wiebke Wolfsgruber; Franz Hofmann; Joseph A Beavo
Individual cerebellar Purkinje cells express different cGMP phosphodiesterases (PDEs): in vivo phosphorylation of cGMP-specific PDE (PDE5) as an indicator of cGMP-dependent protein kinase (PKG) activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(16):6452-9.
2003: Thomas Kleppisch; Wiebke Wolfsgruber; Susanne Feil; Rüdiger Allmann; Carsten T Wotjak; Sandra Goebbels; Klaus-Armin Nave; Franz Hofmann; Robert Feil
Hippocampal cGMP-dependent protein kinase I supports an age- and protein synthesis-dependent component of long-term potentiation but is not essential for spatial reference and contextual memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(14):6005-12.
2003: Cornelia Frisch; Ralf Gerhard; Klaus Aktories; Franz Hofmann; Ingo Just
The complete receptor-binding domain of Clostridium difficile toxin A is required for endocytosis.
Biochemical and biophysical research communications 2003;300(3):706-11.
2003: Andreas Ludwig; Thomas Budde; Juliane Stieber; Sven Moosmang; Christian Wahl; Knut Holthoff; Anke Langebartels; Carsten Wotjak; Thomas Munsch; Xiangang Zong; Susanne Feil; Robert Feil; Marike Lancel; Kenneth R Chien; Arthur Konnerth; Hans-Christian Pape; Martin Biel; Franz Hofmann
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.
The EMBO journal 2003;22(2):216-24.
2003: Angela Koller; Jens Schlossmann; Keith Ashman; Sandrine Uttenweiler; Peter Ruth; Franz Hofmann
Association of phospholamban with a cGMP kinase signaling complex.
Biochemical and biophysical research communications 2003;300(1):155-60.
2003: Jens Schlossmann; Robert Feil; Franz Hofmann
Signaling through NO and cGMP-dependent protein kinases.
Annals of medicine 2003;35(1):21-7.
2002: Hannes Schmidt; Matthias Werner; Paul A Heppenstall; Mechthild Henning; Margret I Moré; Susanne Kühbandner; Gary R Lewin; Franz Hofmann; Robert Feil; Fritz G Rathjen
cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons.
The Journal of cell biology 2002;159(3):489-98.
2002: L'ubica Lacinová; Norbert Klugbauer; Franz Hofmann
Gating of the expressed Cav3.1 calcium channel.
FEBS letters 2002;531(2):235-40.
2002: Manabu Murakami; Bernd K Fleischmann; Carmen De Felipe; Marc Freichel; Claudia Trost; Andreas Ludwig; Ulrich Wissenbach; Herbert Schwegler; Franz Hofmann; Jürgen Hescheler; Veit Flockerzi; Adolfo Cavalié
Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels.
The Journal of biological chemistry 2002;277(43):40342-51.
2002: Norbert Klugbauer; Andrea Welling; Verena Specht; Claudia Seisenberger; Franz Hofmann
L-type Ca2+ channels of the embryonic mouse heart.
European journal of pharmacology 2002;447(2-3):279-84.
2002: Robert Feil; Nicolai Gappa; Mark Rutz; Jens Schlossmann; Christine R Rose; Arthur Konnerth; Sabine Brummer; Susanne Kühbandner; Franz Hofmann
Functional reconstitution of vascular smooth muscle cells with cGMP-dependent protein kinase I isoforms.
Circulation research 2002;90(10):1080-6.
2002: Matthias Löhn; Ulf Muzzulini; Kirill Essin; Suk Ying Tsang; Torsten Kirsch; Jennifer Litteral; Patricia Waldron; Heinke Conrad; Norbert Klugbauer; Franz Hofmann; Hermann Haller; Friedrich C Luft; Yu Huang; Maik Gollasch
Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C.
Journal of hypertension 2002;20(5):885-93.
2002: Sergei D Rybalkin; Irina G Rybalkina; Robert Feil; Franz Hofmann; Joseph A Beavo
Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells.
The Journal of biological chemistry 2002;277(5):3310-7.
2002: Joachim Wegener; Hermann Nawrath; Wiebke Wolfsgruber; Susanne Kühbandner; Claudia Werner; Franz Hofmann; Robert Feil
cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium.
Circulation research 2002;90(1):18-20.
2001: Karel Talavera; Mik Staes; Annelies Janssens; Norbert Klugbauer; Guy Droogmans; Franz Hofmann; Bernd Nilius
Aspartate residues of the Glu-Glu-Asp-Asp (EEDD) pore locus control selectivity and permeation of the T-type Ca(2+) channel alpha(1G).
The Journal of biological chemistry 2001;276(49):45628-35.
2001: I Gülke; Gunther Pfeifer; Jan Liese; M Fritz; Franz Hofmann; Klaus Aktories; Holger Barth
Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile.
Infection and immunity 2001;69(10):6004-11.
2001: Ingo Just; Franz Hofmann; Harald Genth; Ralf Gerhard
Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins.
International journal of medical microbiology : IJMM 2001;291(4):243-50.
2001: Mathias W Seeliger; Christian grimm, Prof Dr. Phil. Nat.; F Ståhlberg; Christoph Friedburg; Gesine B Jaissle; Eberhart Zrenner; H Guo; Charlotte E Remé; Peter Humphries; Franz Hofmann; Martin Biel; Robert Fariss; T Michael Redmond; A Wenzel
New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis.
Nature genetics 2001;29(1):70-4.
2001: A Ammendola; Angela Geiselhöringer; Franz Hofmann; Jens Schlossmann
Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta.
The Journal of biological chemistry 2001;276(26):24153-9.
2001: Else Marais; Norbert Klugbauer; Franz Hofmann
Calcium channel alpha(2)delta subunits-structure and Gabapentin binding.
Molecular pharmacology 2001;59(5):1243-8.
2001: Holger Barth; Gunther Pfeifer; Franz Hofmann; Elke Maier; Roland Benz; Klaus Aktories
Low pH-induced formation of ion channels by clostridium difficile toxin B in target cells.
The Journal of biological chemistry 2001;276(14):10670-6.
2001: Iwan Walev; S C Bhakdi; Franz Hofmann; N Djonder; Angela Valeva; K Aktories; Sucharit Bhakdi
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3185-90.
2001: Xiangang Zong; Juliane Stieber; Andreas Ludwig; Franz Hofmann; Martin Biel
A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.
The Journal of biological chemistry 2001;276(9):6313-9.
2001: Sven Moosmang; Juliane Stieber; Xiangang Zong; Martin Biel; Franz Hofmann; Andreas Ludwig
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
European journal of biochemistry / FEBS 2001;268(6):1646-52.
2001: Marc Freichel; S H Suh; A Pfeifer; U Schweig; Claudia Trost; Petra Weissgerber; M Biel; Stephan E Philipp; Doris Freise; Guy Droogmans; Franz Hofmann; Veit Flockerzi; Bernd Nilius
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice.
Nature cell biology 2001;3(2):121-7.
2001: Mik Staes; Karel Talavera; Norbert Klugbauer; Jean Prenen; Lubica Lacinova; Guy Droogmans; Franz Hofmann; Bernd Nilius
The amino side of the C-terminus determines fast inactivation of the T-type calcium channel alpha1G.
The Journal of physiology 2001;530(Pt 1):35-45.
2000: Claudia Seisenberger; Verena Specht; Andrea Welling; Josef Platzer; Alexander Pfeifer; Susanne Kühbandner; Jörg Striessnig; Norbert Klugbauer; Robert Feil; Franz Hofmann
Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.
The Journal of biological chemistry 2000;275(50):39193-9.
2000: Christian Busch; K Schömig; Franz Hofmann; Klaus Aktories
Characterization of the catalytic domain of Clostridium novyi alpha-toxin.
Infection and immunity 2000;68(11):6378-83.
2000: Matthias Sausbier; R Schubert; V Voigt; C Hirneiss; Alexander Pfeifer; Michael Korth; Thomas Kleppisch; Peter Ruth; Franz Hofmann
Mechanisms of NO/cGMP-dependent vasorelaxation.
Circulation research 2000;87(9):825-30.
2000: Dieter K Meyer; C Olenik; Franz Hofmann; Holger Barth; Jost Leemhuis; I Brünig; Klaus Aktories; Wolfgang Nörenberg
Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):6743-51.
2000: G Bohn; Sven Moosmang; H Conrad; Andreas Ludwig; Franz Hofmann; Norbert Klugbauer
Expression of T- and L-type calcium channel mRNA in murine sinoatrial node.
FEBS letters 2000;481(1):73-6.
2000: Susanne Kühbandner; Sabine Brummer; D Metzger; P Chambon; Franz Hofmann; Robert Feil
Temporally controlled somatic mutagenesis in smooth muscle.
Genesis (New York, N.Y. : 2000) 2000;28(1):15-22.
2000: L Vaca; Juliane Stieber; X Zong; Andreas Ludwig; Franz Hofmann; M Biel
Mutations in the S4 domain of a pacemaker channel alter its voltage dependence.
FEBS letters 2000;479(1-2):35-40.
2000: Annette Hohaus; Michael Poteser; Christoph Romanin; N Klugbauer; Franz Hofmann; Ingo Morano; Hannelore Haase; Klaus Groschner
Modulation of the smooth-muscle L-type Ca2+ channel alpha1 subunit (alpha1C-b) by the beta2a subunit: a peptide which inhibits binding of beta to the I-II linker of alpha1 induces functional uncoupling.
The Biochemical journal 2000;348 Pt 3():657-65.
2000: L'ubica Lacinová; Norbert Klugbauer; Franz Hofmann
Low voltage activated calcium channels: from genes to function.
General physiology and biophysics 2000;19(2):121-36.
2000: Doris Freise; Brigitte Held; Ulrich Wissenbach; A Pfeifer; Claudia Trost; Nina Himmerkus; U Schweig; Marc Freichel; M Biel; Franz Hofmann; Markus Hoth; Veit Flockerzi
Absence of the gamma subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca2+ currents and alters channel inactivation properties.
The Journal of biological chemistry 2000;275(19):14476-81.
2000: Christian Busch; Franz Hofmann; Ralf Gerhard; Klaus Aktories
Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases.
The Journal of biological chemistry 2000;275(18):13228-34.
2000: L'ubica Lacinová; Norbert Klugbauer; Franz Hofmann
State- and isoform-dependent interaction of isradipine with the alpha1C L-type calcium channel.
Pflügers Archiv : European journal of physiology 2000;440(1):50-60.
2000: Franz Hofmann; A Ammendola; Jens Schlossmann
Rising behind NO: cGMP-dependent protein kinases.
Journal of cell science 2000;113 ( Pt 10)():1671-6.
2000: L'ubica Lacinová; Norbert Klugbauer; Franz Hofmann
Regulation of the calcium channel alpha(1G) subunit by divalent cations and organic blockers.
Neuropharmacology 2000;39(7):1254-66.
2000: M Hobom; S Dai; Else Marais; Lubica Lacinova; Franz Hofmann; Norbert Klugbauer
Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit.
The European journal of neuroscience 2000;12(4):1217-26.
2000: Norbert Klugbauer; S Dai; Verena Specht; L'ubica Lacinová; Else Marais; G Bohn; Franz Hofmann
A family of gamma-like calcium channel subunits.
FEBS letters 2000;470(2):189-97.
2000: Jens Schlossmann; A Ammendola; K Ashman; Xiangang Zong; A Huber; G Neubauer; GX Wang; Hans-Dieter Allescher; Michael Korth; Matthias Wilm; Franz Hofmann; Peter Ruth
Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta.
Nature 2000;404(6774):197-201.
2000: Harald Genth; J Selzer; Christian Busch; J Dumbach; Franz Hofmann; Klaus Aktories; Ingo Just
New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization.
Infection and immunity 2000;68(3):1094-101.
2000: Andrea Gerstner; Xiangang Zong; Franz Hofmann; Martin Biel
Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(4):1324-32.
2000: Ingo Just; Franz Hofmann; Klaus Aktories
Molecular mode of action of the large clostridial cytotoxins.
Current topics in microbiology and immunology 2000;250():55-83.
2000: Arie B Vaandrager; Alice G M Bot; Peter Ruth; A Pfeifer; Franz Hofmann; Hugo R de Jonge
Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon.
Gastroenterology 2000;118(1):108-14.
1999: Sven Moosmang; Martin Biel; Franz Hofmann; Andreas Ludwig
Differential distribution of four hyperpolarization-activated cation channels in mouse brain.
Biological chemistry 1999;380(7-8):975-80.
1999: Wolfgang Nörenberg; Franz Hofmann; Peter Illes; Klaus Aktories; Dieter K Meyer
Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA.
British journal of pharmacology 1999;127(5):1060-3.
1999: Martin Biel; Mathias W Seeliger; Alexander Pfeifer; K Kohler; Andrea Gerstner; Andreas Ludwig; Gesine B Jaissle; Sascha Fauser; Eberhart Zrenner; Franz Hofmann
Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7553-7.
1999: L'ubica Lacinová; Norbert Klugbauer; M Hu; Franz Hofmann
Reconstruction of the dihydropyridine site in a non-L-type calcium channel: the role of the IS6 segment.
FEBS letters 1999;451(2):152-6.
1999: Andreas Ludwig; Xiangang Zong; Juliane Stieber; R Hullin; Franz Hofmann; Martin Biel
Two pacemaker channels from human heart with profoundly different activation kinetics.
The EMBO journal 1999;18(9):2323-9.
1999: Steffen Massberg; Matthias Sausbier; Peter Klatt; M Bauer; Alexander Pfeifer; Wolfgang Siess; Reinhard Fässler; Peter Ruth; Fritz Krombach; Franz Hofmann
Increased adhesion and aggregation of platelets lacking cyclic guanosine 3',5'-monophosphate kinase I.
The Journal of experimental medicine 1999;189(8):1255-64.
1999: Norbert Klugbauer; Else Marais; L'ubica Lacinová; Franz Hofmann
A T-type calcium channel from mouse brain.
Pflügers Archiv : European journal of physiology 1999;437(5):710-5.
1999: Norbert Klugbauer; L'ubica Lacinová; Else Marais; M Hobom; Franz Hofmann
Molecular diversity of the calcium channel alpha2delta subunit.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(2):684-91.
1999: S Dai; Norbert Klugbauer; X Zong; Claudia Seisenberger; Franz Hofmann
The role of subunit composition on prepulse facilitation of the cardiac L-type calcium channel.
FEBS letters 1999;442(1):70-4.
1999: Andreas Ludwig; Xiangang Zong; Franz Hofmann; Martin Biel
Structure and function of cardiac pacemaker channels.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 1999;9(4-5):179-86.
1999: Franz Hofmann; L'ubica Lacinová; Norbert Klugbauer
Voltage-dependent calcium channels: from structure to function.
Reviews of physiology, biochemistry and pharmacology 1999;139():33-87.
1999: Martin Biel; Xiangang Zong; Franz Hofmann
Cyclic nucleotide gated channels.
Advances in second messenger and phosphoprotein research 1999;33():231-50.
1999: Martin Biel; Andreas Ludwig; Xiangang Zong; Franz Hofmann
Hyperpolarization-activated cation channels: a multi-gene family.
Reviews of physiology, biochemistry and pharmacology 1999;136():165-81.
1999: Martin Biel; Xiangang Zong; Andreas Ludwig; A Sautter; Franz Hofmann
Structure and function of cyclic nucleotide-gated channels.
Reviews of physiology, biochemistry and pharmacology 1999;135():151-71.
1999: Alexander Pfeifer; Peter Ruth; W Dostmann; Matthias Sausbier; Peter Klatt; Franz Hofmann
Structure and function of cGMP-dependent protein kinases.
Reviews of physiology, biochemistry and pharmacology 1999;135():105-49.
1999: Thomas Kleppisch; Alexander Pfeifer; Peter Klatt; Peter Ruth; A Montkowski; Reinhard Fässler; Franz Hofmann
Long-term potentiation in the hippocampal CA1 region of mice lacking cGMP-dependent kinases is normal and susceptible to inhibition of nitric oxide synthase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(1):48-55.
1998: Holger Barth; J C Preiss; Franz Hofmann; Klaus Aktories
Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis.
The Journal of biological chemistry 1998;273(45):29506-11.
1998: Ralf Gerhard; Gudula Schmidt; Franz Hofmann; Klaus Aktories
Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells.
Infection and immunity 1998;66(11):5125-31.
1998: Xiao-Bo Zhou; Jens Schlossmann; Franz Hofmann; Peter Ruth; Michael Korth
Regulation of stably expressed and native BK channels from human myometrium by cGMP- and cAMP-dependent protein kinase.
Pflügers Archiv : European journal of physiology 1998;436(5):725-34.
1998: Christian Busch; Franz Hofmann; J Selzer; S Munro; D Jeckel; Klaus Aktories
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins.
The Journal of biological chemistry 1998;273(31):19566-72.
1998: Martin Biel; A Sautter; Andreas Ludwig; Franz Hofmann; Xiangang Zong
Cyclic nucleotide-gated channels--mediators of NO:cGMP-regulated processes.
Naunyn-Schmiedeberg's archives of pharmacology 1998;358(1):140-4.
1998: Andreas Ludwig; Xiangang Zong; M Jeglitsch; Franz Hofmann; Martin Biel
A family of hyperpolarization-activated mammalian cation channels.
Nature 1998;393(6685):587-91.
1998: Alexander Pfeifer; Peter Klatt; Steffen Massberg; L Ny; Matthias Sausbier; C Hirneiss; GX Wang; Michael Korth; Attila Aszódi; Karl-Erik Andersson; Fritz Krombach; Artur Mayerhofer; Peter Ruth; Reinhard Fässler; Franz Hofmann
Defective smooth muscle regulation in cGMP kinase I-deficient mice.
The EMBO journal 1998;17(11):3045-51.
1998: A Sautter; Xiangang Zong; Franz Hofmann; Martin Biel
An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4696-701.
1998: G Schmid; Annette Schürmann; C Huppertz; Franz Hofmann; K Aktories; Hans-Georg Joost
Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(4):385-92.
1998: Holger Barth; Franz Hofmann; C Olenik; Ingo Just; Klaus Aktories
The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin.
Infection and immunity 1998;66(4):1364-9.
1998: Christian Reiser; Thomas Lanz; Franz Hofmann; G Hofer; Harald D Rupprecht; Margarete Goppelt-Struebe
Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins.
The Biochemical journal 1998;330 ( Pt 3)():1107-14.
1998: Franz Hofmann; Christian Busch; Klaus Aktories
Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition.
Infection and immunity 1998;66(3):1076-81.
1998: Xiangang Zong; H Zucker; Franz Hofmann; Martin Biel
Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels.
The EMBO journal 1998;17(2):353-62.
1998: L'ubica Lacinová; Franz Hofmann
Isradipine interacts with the open state of the L-type calcium channel at high concentrations.
Receptors & channels 1998;6(3):153-64.
1998: Ulrich Wissenbach; E Bosse-Doenecke; Doris Freise; Andreas Ludwig; M Murakami; Franz Hofmann; Veit Flockerzi
The structure of the murine calcium channel gamma-subunit gene and protein.
Biological chemistry 1998;379(1):45-50.
1997: H Ito; Norbert Klugbauer; Franz Hofmann
Transfer of the high affinity dihydropyridine sensitivity from L-type To non-L-type calcium channel.
Molecular pharmacology 1997;52(4):735-40.
1997: Andrea Welling; Andreas Ludwig; S Zimmer; Norbert Klugbauer; Veit Flockerzi; Franz Hofmann
Alternatively spliced IS6 segments of the alpha 1C gene determine the tissue-specific dihydropyridine sensitivity of cardiac and vascular smooth muscle L-type Ca2+ channels.
Circulation research 1997;81(4):526-32.
1997: A Sautter; Martin Biel; Franz Hofmann
Molecular cloning of cyclic nucleotide-gated cation channel subunits from rat pineal gland.
Brain research. Molecular brain research 1997;48(1):171-5.
1997: Franz Hofmann; Christian Busch; U Prepens; Ingo Just; Klaus Aktories
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin.
The Journal of biological chemistry 1997;272(17):11074-8.
1997: Peter Ruth; Alexander Pfeifer; Simone Kamm; Peter Klatt; W R Dostmann; Franz Hofmann
Identification of the amino acid sequences responsible for high affinity activation of cGMP kinase Ialpha.
The Journal of biological chemistry 1997;272(16):10522-8.
1997: R Eberst; S Dai; Norbert Klugbauer; Franz Hofmann
Identification and functional characterization of a calcium channel gamma subunit.
Pflügers Archiv : European journal of physiology 1997;433(5):633-7.
1997: Andreas Ludwig; V Flockerzi; Franz Hofmann
Regional expression and cellular localization of the alpha1 and beta subunit of high voltage-activated calcium channels in rat brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(4):1339-49.
1997: U Prepens; Ingo Just; Franz Hofmann; Klaus Aktories
ADP-ribosylating and glucosylating toxins as tools to study secretion in RBL cells.
Advances in experimental medicine and biology 1997;419():349-53.
1996: Alexander Pfeifer; Attila Aszódi; U Seidler; Peter Ruth; Franz Hofmann; Reinhard Fässler
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.
Science (New York, N.Y.) 1996;274(5295):2082-6.
1996: Harald Genth; Franz Hofmann; J Selzer; G Rex; Klaus Aktories; Ingo Just
Difference in protein substrate specificity between hemorrhagic toxin and lethal toxin from Clostridium sordellii.
Biochemical and biophysical research communications 1996;229(2):370-4.
1996: T Angelotti; Franz Hofmann
Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha2/delta subunit.
FEBS letters 1996;397(2-3):331-7.
1996: Martin Biel; Xiangang Zong; Franz Hofmann
Cyclic nucleotide-gated cation channels molecular diversity, structure, and cellular functions.
Trends in cardiovascular medicine 1996;6(8):274-80.
1996: J Selzer; Franz Hofmann; G Rex; M Wilm; M Mann; Ingo Just; Klaus Aktories
Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.
The Journal of biological chemistry 1996;271(41):25173-7.
1996: Franz Hofmann; G Rex; Klaus Aktories; Ingo Just
The ras-related protein Ral is monoglucosylated by Clostridium sordellii lethal toxin.
Biochemical and biophysical research communications 1996;227(1):77-81.
1996: Maik Gollasch; C Ried; M Liebold; Hermann Haller; Franz Hofmann; Friedrich C Luft
High permeation of L-type Ca2+ channels at physiological [Ca2+]: homogeneity and dependence on the alpha 1-subunit.
The American journal of physiology 1996;271(3 Pt 1):C842-50.
1996: Xiao-Bo Zhou; Peter Ruth; J Schlossmann; Franz Hofmann; Michael Korth
Protein phosphatase 2A is essential for the activation of Ca2+-activated K+ currents by cGMP-dependent protein kinase in tracheal smooth muscle and Chinese hamster ovary cells.
The Journal of biological chemistry 1996;271(33):19760-7.
1996: Norbert Klugbauer; Franz Hofmann
Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein.
FEBS letters 1996;391(1-2):61-5.
1996: Peter Ruth; S Kamm; U Nau; Alexander Pfeifer; Franz Hofmann
A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24).
Biological chemistry 1996;377(7-8):513-20.
1996: A Schuster; L'ubica Lacinová; Norbert Klugbauer; H Ito; Lutz Birnbaumer; Franz Hofmann
The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines.
The EMBO journal 1996;15(10):2365-70.
1996: R Bangalore; G Mehrke; KJ Gingrich; Franz Hofmann; Robert Kass
Influence of L-type Ca channel alpha 2/delta-subunit on ionic and gating current in transiently transfected HEK 293 cells.
The American journal of physiology 1996;270(5 Pt 2):H1521-8.
1996: Ingo Just; J Selzer; Franz Hofmann; G A Green; Klaus Aktories
Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation.
The Journal of biological chemistry 1996;271(17):10149-53.
1996: Martin Biel; Xiangang Zong; Andreas Ludwig; A Sautter; Franz Hofmann
Molecular cloning and expression of the Modulatory subunit of the cyclic nucleotide-gated cation channel.
The Journal of biological chemistry 1996;271(11):6349-55.
1996: Xiangang Zong; Franz Hofmann
Ca(2+)-dependent inactivation of the class C L-type Ca2+ channel is a property of the alpha 1 subunit.
FEBS letters 1996;378(2):121-5.
1995: C Seisenberger; A Welling; A Schuster; Franz Hofmann
Two stable cell lines for screening of calcium channel blockers.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(6):662-9.
1995: Martin Biel; Xiangang Zong; Franz Hofmann
Molecular diversity of cyclic nucleotide-gated cation channels.
Naunyn-Schmiedeberg's archives of pharmacology 1995;353(1):1-10.
1995: N Wild; F W Herberg; Franz Hofmann; W R Dostmann
Expression of a chimeric, cGMP-sensitive regulatory subunit of the cAMP-dependent protein kinase type I alpha.
FEBS letters 1995;374(3):356-62.
1995: R Feil; J Kellermann; Franz Hofmann
Functional cGMP-dependent protein kinase is phosphorylated in its catalytic domain at threonine-516.
Biochemistry 1995;34(40):13152-8.
1995: L'ubica Lacinová; Andreas Ludwig; E Bosse; Veit Flockerzi; Franz Hofmann
The block of the expressed L-type calcium channel is modulated by the beta 3 subunit.
FEBS letters 1995;373(2):103-7.
1995: L'ubica Lacinová; A Welling; E Bosse; Peter Ruth; Veit Flockerzi; Franz Hofmann
Interaction of Ro 40-5967 and verapamil with the stably expressed alpha 1-subunit of the cardiac L-type calcium channel.
The Journal of pharmacology and experimental therapeutics 1995;274(1):54-63.
1995: Xiangang Zong; J Schreieck; G Mehrke; A Welling; A Schuster; E Bosse; Veit Flockerzi; Franz Hofmann
On the regulation of the expressed L-type calcium channel by cAMP-dependent phosphorylation.
Pflügers Archiv : European journal of physiology 1995;430(3):340-7.
1995: Alexander Pfeifer; B Nürnberg; S Kamm; M Uhde; G Schultz; Peter Ruth; Franz Hofmann
Cyclic GMP-dependent protein kinase blocks pertussis toxin-sensitive hormone receptor signaling pathways in Chinese hamster ovary cells.
The Journal of biological chemistry 1995;270(16):9052-9.
1995: Norbert Klugbauer; L Lacinova; Veit Flockerzi; Franz Hofmann
Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells.
The EMBO journal 1995;14(6):1084-90.
1995: A Welling; L Lacinova; K Donatin; Andreas Ludwig; E Bosse; Veit Flockerzi; Franz Hofmann
Expression of the L-type calcium channel with two different beta subunits and its modulation by Ro 40-5967.
Pflügers Archiv : European journal of physiology 1995;429(3):400-11.
1994: G Mehrke; Xiangang Zong; Veit Flockerzi; Franz Hofmann
The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1483-8.
1994: M Distler; Martin Biel; Veit Flockerzi; Franz Hofmann
Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells.
Neuropharmacology 1994;33(11):1275-82.
1994: T Kleppisch; K Pedersen; C Strübing; E Bosse-Doenecke; Veit Flockerzi; Franz Hofmann; Jürgen Hescheler
Double-pulse facilitation of smooth muscle alpha 1-subunit Ca2+ channels expressed in CHO cells.
The EMBO journal 1994;13(11):2502-7.
1994: Martin Biel; Xiangang Zong; M Distler; E Bosse; Norbert Klugbauer; M Murakami; Veit Flockerzi; Franz Hofmann
Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3505-9.
1994: H Haase; G Wallukat; Veit Flockerzi; Wolfgang Nastainczyk; Franz Hofmann
Detection of skeletal muscle calcium channel subunits in cultured neonatal rat cardiac myocytes.
Receptors & channels 1994;2(1):41-52.
1994: Dafna Singer-Lahat; Ilana Lotan; Martin Biel; Veit Flockerzi; Franz Hofmann; Nathan Dascal
Cardiac calcium channels expressed in Xenopus oocytes are modulated by dephosphorylation but not by cAMP-dependent phosphorylation.
Receptors & channels 1994;2(3):215-26.
1993: R Feil; S Müller; Franz Hofmann
High-level expression of functional cGMP-dependent protein kinase using the baculovirus system.
FEBS letters 1993;336(1):163-7.
1993: A Welling; Y W Kwan; E Bosse; Veit Flockerzi; Franz Hofmann; Robert Kass
Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity.
Circulation research 1993;73(5):974-80.
1993: A Welling; E Bosse; Adolfo Cavalié; R Bottlender; Andreas Ludwig; Wolfgang Nastainczyk; Veit Flockerzi; Franz Hofmann
Stable co-expression of calcium channel alpha 1, beta and alpha 2/delta subunits in a somatic cell line.
The Journal of physiology 1993;471():749-65.
1993: R Feil; Marina Bigl; Peter Ruth; Franz Hofmann
Expression of cGMP-dependent protein kinase in Escherichia coli.
Molecular and cellular biochemistry 1993;127-128():71-80.
1993: Martin Biel; W Altenhofen; R Hullin; J Ludwig; Marc Freichel; Veit Flockerzi; Nathan Dascal; U Benjamin Kaupp; Franz Hofmann
Primary structure and functional expression of a cyclic nucleotide-gated channel from rabbit aorta.
FEBS letters 1993;329(1-2):134-8.
1993: S Nishimura; Hiroshi Takeshima; Franz Hofmann; Veit Flockerzi; K Imoto
Requirement of the calcium channel beta subunit for functional conformation.
FEBS letters 1993;324(3):283-6.
1993: Peter Ruth; G X Wang; I Boekhoff; B May; Alexander Pfeifer; R Penner; M Korth; H Breer; Franz Hofmann
Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-trisphosphate production.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2623-7.
1993: Roger Hullin; Martin Biel; Veit Flockerzi; Franz Hofmann
Tissue-specific expression of calcium channels.
Trends in cardiovascular medicine 1993;3(2):48-53.
1992: A Keilbach; Peter Ruth; Franz Hofmann
Detection of cGMP dependent protein kinase isozymes by specific antibodies.
European journal of biochemistry / FEBS 1992;208(2):467-73.
1992: Dafna Singer-Lahat; E Gershon; Ilana Lotan; R Hullin; Martin Biel; Veit Flockerzi; Franz Hofmann; Nathan Dascal
Modulation of cardiac Ca2+ channels in Xenopus oocytes by protein kinase C.
FEBS letters 1992;306(2-3):113-8.
1992: E Bosse; R Bottlender; T Kleppisch; Jürgen Hescheler; A Welling; Franz Hofmann; Veit Flockerzi
Stable and functional expression of the calcium channel alpha 1 subunit from smooth muscle in somatic cell lines.
The EMBO journal 1992;11(6):2033-8.
1992: Franz Hofmann; W Dostmann; A Keilbach; W Landgraf; Peter Ruth
Structure and physiological role of cGMP-dependent protein kinase.
Biochimica et biophysica acta 1992;1135(1):51-60.
1992: A Welling; J Felbel; K Peper; Franz Hofmann
Hormonal regulation of calcium current in freshly isolated airway smooth muscle cells.
The American journal of physiology 1992;262(3 Pt 1):L351-9.
1992: R Hullin; Dafna Singer-Lahat; Marc Freichel; Martin Biel; Nathan Dascal; Franz Hofmann; Veit Flockerzi
Calcium channel beta subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain.
The EMBO journal 1992;11(3):885-90.
1992: W Landgraf; Peter Ruth; A Keilbach; B May; A Welling; Franz Hofmann
Cyclic GMP-dependent protein kinase and smooth muscle relaxation.
Journal of cardiovascular pharmacology 1992;20 Suppl 1():S18-22.
1992: A Welling; E Bosse; Peter Ruth; R Bottlender; Veit Flockerzi; Franz Hofmann
Expression and regulation of cardiac and smooth muscle calcium channels.
Japanese journal of pharmacology 1992;58 Suppl 2():258P-262P.
1991: Peter Ruth; W Landgraf; A Keilbach; B May; C Egleme; Franz Hofmann
The activation of expressed cGMP-dependent protein kinase isozymes I alpha and I beta is determined by the different amino-termini.
European journal of biochemistry / FEBS 1991;202(3):1339-44.
1991: D Singer; Martin Biel; Ilana Lotan; Veit Flockerzi; Franz Hofmann; Nathan Dascal
The roles of the subunits in the function of the calcium channel.
Science (New York, N.Y.) 1991;253(5027):1553-7.
1991: Martin Biel; R Hullin; S Freundner; D Singer; N Dascal; Veit Flockerzi; Franz Hofmann
Tissue-specific expression of high-voltage-activated dihydropyridine-sensitive L-type calcium channels.
European journal of biochemistry / FEBS 1991;200(1):81-8.
1991: Toni Schneider; S Regulla; Franz Hofmann
The devapamil-binding site of the purified skeletal muscle receptor for organic-calcium channel blockers is modulated by micromolar and millimolar concentrations of Ca2+.
European journal of biochemistry / FEBS 1991;200(1):245-53.
1991: Veit Flockerzi; E Bosse; Martin Biel; R Hullin; Franz Hofmann
High voltage activated calcium channels: molecular composition and function.
European heart journal 1991;12 Suppl D():95-8.
1991: Y Mori; T Friedrich; M S Kim; A Mikami; Junichi Nakai; Peter Ruth; E Bosse; Franz Hofmann; Veit Flockerzi; Teiichi Furuichi
Primary structure and functional expression from complementary DNA of a brain calcium channel.
Nature 1991;350(6317):398-402.
1991: S Regulla; Toni Schneider; Wolfgang Nastainczyk; H E Meyer; Franz Hofmann
Identification of the site of interaction of the dihydropyridine channel blockers nitrendipine and azidopine with the calcium-channel alpha 1 subunit.
The EMBO journal 1991;10(1):45-9.
1991: A Welling; J Felbel; K Peper; Franz Hofmann
Beta-adrenergic receptor stimulates L-type calcium current in adult smooth muscle cells.
Blood vessels 1991;28(1-3):154-8.
1990: Martin Biel; Peter Ruth; E Bosse; R Hullin; W Stühmer; Veit Flockerzi; Franz Hofmann
Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung.
FEBS letters 1990;269(2):409-12.
1990: W Nastainczyk; Andreas Ludwig; Franz Hofmann
The dihydropyridine-sensitive calcium channel of the skeletal muscle: biochemistry and structure.
General physiology and biophysics 1990;9(4):321-9.
1990: E Bosse; S Regulla; Martin Biel; Peter Ruth; H E Meyer; Veit Flockerzi; Franz Hofmann
The cDNA and deduced amino acid sequence of the gamma subunit of the L-type calcium channel from rabbit skeletal muscle.
FEBS letters 1990;267(1):153-6.
1989: T Ecker; C Göbel; R Hullin; R Rettig; G Seitz; Franz Hofmann
Decreased cardiac concentration of cGMP kinase in hypertensive animals. An index for cardiac vascularization?
Circulation research 1989;65(5):1361-9.
1989: Peter Ruth; A Röhrkasten; Martin Biel; E Bosse; S Regulla; H E Meyer; Veit Flockerzi; Franz Hofmann
Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle.
Science (New York, N.Y.) 1989;245(4922):1115-8.
1989: W Wernet; Veit Flockerzi; Franz Hofmann
The cDNA of the two isoforms of bovine cGMP-dependent protein kinase.
FEBS letters 1989;251(1-2):191-6.
1989: A Welling; J Felbel; K Peper; Franz Hofmann
Direct hormonal regulation of smooth muscle calcium current.
Journal of protein chemistry 1989;8(3):417-9.
1989: W Landgraf; Franz Hofmann
The amino terminus regulates binding to and activation of cGMP-dependent protein kinase.
European journal of biochemistry / FEBS 1989;181(3):643-50.
1989: Franz Hofmann; Toni Schneider; A Röhrkasten; Wolfgang Nastainczyk; M Sieber; Peter Ruth; Veit Flockerzi
[Calcium channels: structure and function of receptors for calcium channel blockers in skeletal muscle].
Arzneimittel-Forschung 1989;39(1A):164-8.
1989: DJ Pelzer; A O Grant; Adolfo Cavalié; S Pelzer; M Sieber; Franz Hofmann; W Trautwein
Calcium channels reconstituted from the skeletal muscle dihydropyridine receptor protein complex and its alpha 1 peptide subunit in lipid bilayers.
Annals of the New York Academy of Sciences 1989;560():138-54.
1988: H Jahn; Wolfgang Nastainczyk; A Röhrkasten; Toni Schneider; Franz Hofmann
Site-specific phosphorylation of the purified receptor for calcium-channel blockers by cAMP- and cGMP-dependent protein kinases, protein kinase C, calmodulin-dependent protein kinase II and casein kinase II.
European journal of biochemistry / FEBS 1988;178(2):535-42.
1988: J Felbel; B Trockur; T Ecker; W Landgraf; Franz Hofmann
Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.
The Journal of biological chemistry 1988;263(32):16764-71.
1988: A Röhrkasten; H E Meyer; Wolfgang Nastainczyk; M Sieber; Franz Hofmann
cAMP-dependent protein kinase rapidly phosphorylates serine- 687 of the skeletal muscle receptor for calcium channel blockers.
The Journal of biological chemistry 1988;263(30):15325-9.
1988: Toni Schneider; Franz Hofmann
The bovine cardiac receptor for calcium channel blockers is a 195-kDa protein.
European journal of biochemistry / FEBS 1988;174(2):369-75.
1988: W Landgraf; M Rack; W G Heil; Franz Hofmann
8-(2-Carboxymethylthio)-cGMP, a site-1-selective compound for cGMP-dependent protein kinase.
European journal of biochemistry / FEBS 1988;172(2):439-44.
1988: W Wernet; M Sieber; W Landgraf; Franz Hofmann
Rabbit skeletal muscle microsomes contain two distinct phenylalkylamine-binding sites.
European journal of biochemistry / FEBS 1988;172(1):233-8.
1988: A Röhrkasten; Wolfgang Nastainczyk; M Sieber; H Jahn; S Regulla; Franz Hofmann
Phosphorylation of the purified CaCB-receptor.
Journal of cardiovascular pharmacology 1988;12 Suppl 5():S43-6.
1988: Franz Hofmann; H J Oeken; Toni Schneider; M Sieber
The biochemical properties of L-type calcium channels.
Journal of cardiovascular pharmacology 1988;12 Suppl 1():S25-30.
1987: Wolfgang Nastainczyk; A Röhrkasten; M Sieber; C Rudolph; C Schächtele; D Marmè; Franz Hofmann
Phosphorylation of the purified receptor for calcium channel blockers by cAMP kinase and protein kinase C.
European journal of biochemistry / FEBS 1987;169(1):137-42.
1987: W G Heil; W Landgraf; Franz Hofmann
A catalytically active fragment of cGMP-dependent protein kinase. Occupation of its cGMP-binding sites does not affect its phosphotransferase activity.
European journal of biochemistry / FEBS 1987;168(1):117-21.
1987: W Trautwein; Adolfo Cavalié; Veit Flockerzi; Franz Hofmann; DJ Pelzer
Modulation of calcium channel function by phosphorylation in guinea pig ventricular cells and phospholipid bilayer membranes.
Circulation research 1987;61(4 Pt 2):I17-23.
1987: M Sieber; Wolfgang Nastainczyk; V Zubor; W Wernet; Franz Hofmann
The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel.
European journal of biochemistry / FEBS 1987;167(1):117-22.
1987: M Sieber; Wolfgang Nastainczyk; A Röhrkasten; Franz Hofmann
Reconstitution of the purified receptor for calcium channel blockers.
Biomedica biochimica acta 1987;46(8-9):S357-62.
1986: Veit Flockerzi; H J Oeken; Franz Hofmann
Purification of a functional receptor for calcium-channel blockers from rabbit skeletal-muscle microsomes.
European journal of biochemistry / FEBS 1986;161(1):217-24.
1986: Veit Flockerzi; H J Oeken; Franz Hofmann; DJ Pelzer; Adolfo Cavalié; W Trautwein
Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel.
Nature 1986;323(6083):66-8.
1986: H J Oeken; E von Nettelbladt; M Zimmer; Veit Flockerzi; Peter Ruth; Franz Hofmann
Cardiac sarcoplasmic reticulum contains a low-affinity site for phenylalkylamines.
European journal of biochemistry / FEBS 1986;156(3):661-7.
1986: Peter Ruth; Veit Flockerzi; H J Oeken; Franz Hofmann
Solubilization of the bovine cardiac sarcolemmal binding sites for calcium channel blockers.
European journal of biochemistry / FEBS 1986;155(3):613-20.
1986: W Landgraf; R Hullin; C Göbel; Franz Hofmann
Phosphorylation of cGMP-dependent protein kinase increases the affinity for cyclic AMP.
European journal of biochemistry / FEBS 1986;154(1):113-7.
1985: Franz Hofmann; H P Gensheimer; W Landgraf; R Hullin; B Jastorff
Diastereomers of adenosine 3',5'-monothionophosphate (cAMP[S]) antagonize the activation of cGMP-dependent protein kinase.
European journal of biochemistry / FEBS 1985;150(1):85-8.