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Wolf Peter Hofmann

Research Profile

Disorders

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Hepacivirus

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Publications

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Roeland Zoutendijk; Thomas Berg; Ashley Brown; Maria Buti; Katja Deterding; Massimo Fasano; Bettina E Hansen; Wolf Peter Hofmann; Harry L A Janssen; David J Mutimer; Joerg Petersen; Jurrien G P Reijnders; Milan J Sonneveld; Heiner Wedemeyer; Fabien Zoulim
Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis.
J Peveling-Oberhag; Christoph Sarrazin; S Susser; Stefan Zeuzem; H Farnik; Eva Herrmann; Bernd Kronenberger; Wolf Peter Hofmann
Dynamics of hepatitis B virus quasispecies heterogeneity and virologic response in patients receiving low-to-moderate genetic barrier nucleoside analogs.
Adriaan J van der Meer; Bart J Veldt; Heiner Wedemeyer; Stefan Zeuzem; Lorenz Kuske; Frank Lammert; Michael P Manns; Robert J de Knegt; Andrés Duarte-Rojo; Jean-François Dufour; Jordan J Feld; Bettina E Hansen; E Jenny Heathcote; Wolf Peter Hofmann; Harry L A Janssen
Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis.

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All Publications

2013: Roeland Zoutendijk; Thomas Berg; Ashley Brown; Maria Buti; Katja Deterding; Massimo Fasano; Bettina E Hansen; Wolf Peter Hofmann; Harry L A Janssen; David J Mutimer; Joerg Petersen; Jurrien G P Reijnders; Milan J Sonneveld; Heiner Wedemeyer; Fabien Zoulim
Virological response to entecavir is associated with a better clinical outcome in chronic hepatitis B patients with cirrhosis.
Gut 2013;62(5):760-5.
2013: J Peveling-Oberhag; Christoph Sarrazin; S Susser; Stefan Zeuzem; H Farnik; Eva Herrmann; Bernd Kronenberger; Wolf Peter Hofmann
Dynamics of hepatitis B virus quasispecies heterogeneity and virologic response in patients receiving low-to-moderate genetic barrier nucleoside analogs.
Journal of viral hepatitis 2013;20(4):234-9.
2012: Adriaan J van der Meer; Bart J Veldt; Heiner Wedemeyer; Stefan Zeuzem; Lorenz Kuske; Frank Lammert; Michael P Manns; Robert J de Knegt; Andrés Duarte-Rojo; Jean-François Dufour; Jordan J Feld; Bettina E Hansen; E Jenny Heathcote; Wolf Peter Hofmann; Harry L A Janssen
Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis.
JAMA : the journal of the American Medical Association 2012;308(24):2584-93.
2012: Johannes Vermehren; Stefan Zeuzem; Olga Zimmermann; Jörg Bojunga; Eva Herrmann; Wolf Peter Hofmann; Andreas Polta; Thierry Poynard; Christoph Sarrazin; Mireen Friedrich-Rust
Comparison of acoustic radiation force impulse imaging with transient elastography for the detection of complications in patients with cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver 2012;32(5):852-8.
2012: Johannes Vermehren; Stefan Zeuzem; Amina Carlebach; Nicole Forestier; Mireen Friedrich-Rust; Peter Gute; Eva Herrmann; Gaby Knecht; Thomas Lutz; Axel Mueller; Thierry Poynard; Christoph Sarrazin; Annika Vermehren; Wolf Peter Hofmann
Assessment of liver fibrosis and associated risk factors in HIV-infected individuals using transient elastography and serum biomarkers.
BMC gastroenterology 2012;12():27.
2011: Jörn Lötsch; Christina Schlecker; Alfred Ultsch; Stefan Zeuzem; Gerd Geisslinger; Wolf Peter Hofmann; Alexandra Doehring
Single and combined IL28B, ITPA and SLC28A3 host genetic markers modulating response to anti-hepatitis C therapy.
Pharmacogenomics 2011;12(12):1729-40.
2011: Harald Farnik; Eva Herrmann; Wolf Peter Hofmann; Christian Markus Lange; Christoph Sarrazin; Jörg Trojan; Martin Walter Welker; Stefan Zeuzem; Regina Allwinn; Annemarie Berger; Bernd Kronenberger
Nucleos(t)ide analogue treatment reduces apoptotic activity in patients with chronic hepatitis B.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2011;52(3):204-9.
2011: Roeland Zoutendijk; Thomas Berg; Ashley Brown; Maria Buti; Katja Deterding; Bettina E Hansen; Wolf Peter Hofmann; Harry L A Janssen; Marc Luetgehetmann; David Mutimer; Ye Oo; Jörg Petersen; Pierre Pradat; Jurriën G P Reijnders; Teresa Santantonio; Florian van Bommel; Heiner Wedemeyer; Fabien Zoulim
Entecavir treatment for chronic hepatitis B: adaptation is not needed for the majority of naïve patients with a partial virological response.
Hepatology (Baltimore, Md.) 2011;54(2):443-51.
2011: Christian M Lange; Hans-Anton Lehr; Jörn Lötsch; Christian Moench; Darius Moradpour; Beat Müllhaupt; Manuel Pascual; Christoph Sarrazin; Ying Shi; Stefan Zeuzem; Anca T Antonino; Wolf Otto Bechstein; Stephanie Bibert; Pierre-Yves Bochud; Alexandra Doehring; Harald Farnik; Martin-Leo Hansmann; Wolf Peter Hofmann
Impact of donor and recipient IL28B rs12979860 genotypes on hepatitis C virus liver graft reinfection.
Journal of hepatology 2011;55(2):322-7.
2011: Martin Walter Welker; Stefan Zeuzem; Eva Herrmann; Wolf Peter Hofmann; Christian Markus Lange; Christoph Sarrazin; Bernd Kronenberger
CD81 expression for discrimination between sustained virologic response and relapse in patients with chronic hepatitis C.
Scandinavian journal of gastroenterology 2011;46(7-8):973-80.
2011: Georg Dultz; Alireza Azizi; Bernd Kronenberger; Ulrike Mihm; Christoph Sarrazin; Ulrike Sarrazin; Thomas J Vogl; Stefan Zeuzem; Wolf Peter Hofmann
Portal vein thrombosis as complication of romiplostim treatment in a cirrhotic patient with hepatitis C-associated immune thrombocytopenic purpura.
Journal of hepatology 2011;55(1):229-32.
2011: Wolf Peter Hofmann; Stefan Zeuzem
A new standard of care for the treatment of chronic HCV infection.
Nature reviews. Gastroenterology & hepatology 2011;8(5):257-64.
2011: Wolf Peter Hofmann; Ursel Karey; Jörn Lötsch; Ulrike Mihm; Carola Osbahr; Christoph Sarrazin; Simone Susser; Christoph Welsch; Stefan Zeuzem; Tje Lin Chung; Eva Herrmann
Impact of ribavirin on HCV replicon RNA decline during treatment with interferon-α and the protease inhibitors boceprevir or telaprevir.
Antiviral therapy 2011;16(5):695-704.
2010: Martin Walter Welker; Michael von Wagner; Dana Ochs; Vincent Zimmer; Wolf Peter Hofmann; Albrecht Piiper; Rolf W Hartmann; Eva Herrmann; Stefan Zeuzem; Bernd Kronenberger
Influence of amantadine on CD81 expression on lymphocytes in chronic hepatitis C.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010;42(10):735-40.
2010: Markus Bickel; Evrim Anadol; Martin Vogel; Wolf Peter Hofmann; Nils von Hentig; Johannes Kuetscher; Michael Kurowski; Christian Moench; Tessa Lennemann; Thomas Lutz; Wolf Otto Bechstein; Hans Reinhard Brodt; Jürgen Rockstroh
Daily dosing of tacrolimus in patients treated with HIV-1 therapy containing a ritonavir-boosted protease inhibitor or raltegravir.
The Journal of antimicrobial chemotherapy 2010;65(5):999-1004.
2010: Ulrike Mihm; Wolf Peter Hofmann; Christoph Welsch; A Polta; Thomas Lengauer; Stefan Zeuzem; Christoph Sarrazin; Eva Herrmann
Effect of ribavirin on the frequency of RNase L cleavage sites within the hepatitis C viral genome.
Journal of viral hepatitis 2010;17(3):217-21.
2010: Jan Peveling-Oberhag; Stefan Zeuzem; Wolf Peter Hofmann
Antiviral therapy of chronic hepatitis C in patients with advanced liver disease and after liver transplantation.
Medical microbiology and immunology 2010;199(1):1-10.
2009: Wolf Peter Hofmann; Stefan Zeuzem
Advanced chronic hepatitis C: how to handle if you cannot halt?
Hepatology (Baltimore, Md.) 2009;49(4):1385-7.
2009: Ulrike Mihm; Oliver Ackermann; Christoph Welsch; Eva Herrmann; Wolf Peter Hofmann; Natalia Grigorian; Martin Walter Welker; Thomas Lengauer; Stefan Zeuzem; Christoph Sarrazin
Clinical relevance of the 2'-5'-oligoadenylate synthetase/RNase L system for treatment response in chronic hepatitis C.
Journal of hepatology 2009;50(1):49-58.
2008: Wolf Peter Hofmann; Eva Herrmann; Christoph Sarrazin; Stefan Zeuzem
Ribavirin mode of action in chronic hepatitis C: from clinical use back to molecular mechanisms.
Liver international : official journal of the International Association for the Study of the Liver 2008;28(10):1332-43.
2007: Bart J Veldt; E Jenny Heathcote; Heiner Wedemeyer; Jürg Reichen; Wolf Peter Hofmann; Stefan Zeuzem; Michael P Manns; Bettina E Hansen; Solko W Schalm; Harry L A Janssen
Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis.
Annals of internal medicine 2007;147(10):677-84.
2007: Wolf Peter Hofmann; Christoph Welsch; Yoshitomo Takahashi; Hiroaki Miyajima; Ulrike Mihm; Christoph Krick; Stefan Zeuzem; Christoph Sarrazin
Identification and in silico characterization of a novel compound heterozygosity associated with hereditary aceruloplasminemia.
Scandinavian journal of gastroenterology 2007;42(9):1088-94.
2007: Wolf Peter Hofmann; B Fernandez; Eva Herrmann; Christoph Welsch; Ulrike Mihm; Bernd Kronenberger; G Feldmann; U Spengler; Stefan Zeuzem; Christoph Sarrazin
Somatic hypermutation and mRNA expression levels of the BCL-6 gene in patients with hepatitis C virus-associated lymphoproliferative diseases.
Journal of viral hepatitis 2007;14(7):484-91.
2007: Martin Walter Welker; Wolf Peter Hofmann; Christoph Welsch; Michael von Wagner; Eva Herrmann; Thomas Lengauer; Stefan Zeuzem; Christoph Sarrazin
Correlation of amino acid variations within nonstructural 4B protein with initial viral kinetics during interferon-alpha-based therapy in HCV-1b-infected patients.
Journal of viral hepatitis 2007;14(5):338-49.
2007: Wolf Peter Hofmann; Andreas Polta; Eva Herrmann; Ulrike Mihm; Bernd Kronenberger; Tanja Sonntag; Volker Lohmann; Barbara Schönberger; Stefan Zeuzem; Christoph Sarrazin
Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy.
Gastroenterology 2007;132(3):921-30.
2007: Ankur Goyal; Wolf Peter Hofmann; Eva Hermann; Stella Traver; Syed Hissar; Naveen Arora; Hubert E Blum; Stefan Zeuzem; Christoph Sarrazin; Shiv K Sarin
The hepatitis C virus NS5A protein and response to interferon alpha: mutational analyses in patients with chronic HCV genotype 3a infection from India.
Medical microbiology and immunology 2007;196(1):11-21.
2007: Bernd Kronenberger; Stefan Zeuzem; Christoph Sarrazin; Ulrike Mihm; Michael von Wagner; Wolf Peter Hofmann; Albrecht Piiper; Eva Herrmann
Dynamics of apoptotic activity during antiviral treatment of patients with chronic hepatitis C.
Antiviral therapy 2007;12(5):779-87.
2007: Anette Wohnsland; Wolf Peter Hofmann; Christoph Sarrazin
Viral determinants of resistance to treatment in patients with hepatitis C.
Clinical microbiology reviews 2007;20(1):23-38.
2006: Bernd Kronenberger; Eva Herrmann; Wolf Peter Hofmann; Heiner Wedemeyer; Martina Sester; Ulrike Mihm; Temam Ghaliai; Stefan Zeuzem; Christoph Sarrazin
Dynamics of CD81 expression on lymphocyte subsets during interferon-alpha-based antiviral treatment of patients with chronic hepatitis C.
Journal of leukocyte biology 2006;80(2):298-308.
2006: Christoph Sarrazin; Barbara C Gärtner; Dorothea Sizmann; Rainer Babiel; Ulrike Mihm; Wolf Peter Hofmann; Michael von Wagner; Stefan Zeuzem
Comparison of conventional PCR with real-time PCR and branched DNA-based assays for hepatitis C virus RNA quantification and clinical significance for genotypes 1 to 5.
Journal of clinical microbiology 2006;44(3):729-37.
2006: Ulrike Mihm; Natalia Grigorian; Christoph Welsch; Eva Herrmann; Bernd Kronenberger; Gerlinde Teuber; Michael von Wagner; Wolf Peter Hofmann; Mario Albrecht; Thomas Lengauer; Stefan Zeuzem; Christoph Sarrazin
Amino acid variations in hepatitis C virus p7 and sensitivity to antiviral combination therapy with amantadine in chronic hepatitis C.
Antiviral therapy 2006;11(4):507-19.
2006: Wolf Peter Hofmann; H Bock; C Weber; W Tacke; R Pfaff; R Kihn; G Moog; H U Kellner; M Schöfer; B Frick; P Berg; A Rambow; Mireen Friedrich-Rust; Eva Herrmann; Christoph Sarrazin; Stefan Zeuzem
[Effectiveness of antiviral therapy in patients with chronic hepatitis C treated by private practice gastroenterologists].
Zeitschrift für Gastroenterologie 2006;44(1):25-31.
2005: Ulrike Mihm; Barbara C Gärtner; Dominik Faust; Wolf Peter Hofmann; Christoph Sarrazin; Stefan Zeuzem; Eva Herrmann
Viral kinetics in patients with lamivudine-resistant hepatitis B during adefovir-lamivudine combination therapy.
Journal of hepatology 2005;43(2):217-24.
2005: Wolf Peter Hofmann; Volker Dries; Eva Herrmann; Barbara C Gärtner; Stefan Zeuzem; Christoph Sarrazin
Comparison of transcription mediated amplification (TMA) and reverse transcription polymerase chain reaction (RT-PCR) for detection of hepatitis C virus RNA in liver tissue.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005;32(4):289-93.
2005: Ulrike Mihm; Wolf Peter Hofmann; Bernd Kronenberger; Michael von Wagner; Stefan Zeuzem; Christoph Sarrazin
Highly sensitive hepatitis C virus RNA detection assays for decision of treatment (dis)continuation in patients with chronic hepatitis C.
Journal of hepatology 2005;42(4):605-6.
2005: Wolf Peter Hofmann; Stefan Zeuzem; Christoph Sarrazin
Hepatitis C virus-related resistance mechanisms to interferon alpha-based antiviral therapy.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 2005;32(2):86-91.
2004: Wolf Peter Hofmann; Eva Herrmann; Bernd Kronenberger; Christian Merkwirth; Christoph Welsch; Thomas Lengauer; Stefan Zeuzem; Christoph Sarrazin
Association of HCV-related mixed cryoglobulinemia with specific mutational pattern of the HCV E2 protein and CD81 expression on peripheral B lymphocytes.
Blood 2004;104(4):1228-9.
2004: Bernd Kronenberger; Christoph Sarrazin; Wolf Peter Hofmann; Michael von Wagner; Eva Herrmann; Christoph Welsch; Robert Elez; Brigitte Rüster; Albrecht Piiper; Stefan Zeuzem
Mutations in the putative HCV-E2 CD81 binding regions and correlation with cell surface CD81 expression.
Journal of viral hepatitis 2004;11(4):310-8.
2003: Wolf Peter Hofmann; Christoph Sarrazin; Bernd Kronenberger; Barbara Schönberger; Katharina Bruch; Stefan Zeuzem
Mutations within the CD81-binding sites and hypervariable region 2 of the envelope 2 protein: correlation with treatment response in hepatitis C virus-infected patients.
The Journal of infectious diseases 2003;187(6):982-7.