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Jirina Hofmanová

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Jirina Hofmanová; Alois Kozubík; Miroslav Ciganek; Ladislav Dušek; Josef Slavík; Lenka Stixová; Alena Vaculová; Miroslav Machala
Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids.
Lenka Kočí; Martina Hýžd'alová; Alena Vaculová; Jirina Hofmanová; Alois Kozubík
Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cells.
Jaromír Mikeš; Martina Hýžďalová; Lenka Kočí; Rastislav Jendželovský; Ján Kovaľ; Alena Vaculová; Jirina Hofmanová; Alois Kozubík; Peter Fedoročko
Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.

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2012: Jirina Hofmanová; Alois Kozubík; Miroslav Ciganek; Ladislav Dušek; Josef Slavík; Lenka Stixová; Alena Vaculová; Miroslav Machala
Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids.
The Journal of nutritional biochemistry 2012;23(6):539-48.
2011: Lenka Kočí; Martina Hýžd'alová; Alena Vaculová; Jirina Hofmanová; Alois Kozubík
Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cells.
Cytokine 2011;55(1):34-9.
2011: Jaromír Mikeš; Martina Hýžďalová; Lenka Kočí; Rastislav Jendželovský; Ján Kovaľ; Alena Vaculová; Jirina Hofmanová; Alois Kozubík; Peter Fedoročko
Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2011;10(4):626-32.
2011: Olga Vondálová Blanárová; Iva Jelínková; Arpád Szöor; Belma Skender; Karel Soucek; Viktor Horváth; Alena Vaculová; Ladislav Andera; Petr Sova; János Szöllosi; Jirina Hofmanová; György Vereb; Alois Kozubík
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.
Carcinogenesis 2011;32(1):42-51.
2010: Lenka Švihálková-Šindlerová; Vendula Foltinová; Alena Vaculová; Viktor Horváth; Karel Soucek; Petr Sova; Jirina Hofmanová; Alois Kozubík
LA-12 overcomes confluence-dependent resistance of HT-29 colon cancer cells to Pt (II) compounds.
Anticancer research 2010;30(4):1183-8.
2010: Karel Soucek; Pavla Gajdusková; Marie Brázdová; Martina Hýzd'alová; Lenka Kocí; David Vydra; Radek Trojanec; Zuzana Pernicová; Lenka Lentvorská; Marián Hajdúch; Jirina Hofmanová; Alois Kozubík
Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation.
Cancer genetics and cytogenetics 2010;197(2):107-16.
2009: Rastislav Jendzelovský; Jaromir Mikes; Ján Koval'; Karel Soucek; Jirina Procházková; Martin Kello; Veronika Sacková; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2009;8(12):1716-23.
2009: Alena Vaculová; Jirina Hofmanová; Jirina Zatloukalová; Alois Kozubík
Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines.
Experimental cell research 2009;315(19):3259-66.
2009: Lenka Stixová; Jirina Procházková; Karel Soucek; Jirina Hofmanová; Alois Kozubík
5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway.
Molecular and cellular biochemistry 2009;330(1-2):229-38.
2009: Jirina Procházková; Lenka Stixová; Karel Soucek; Jirina Hofmanová; Alois Kozubík
Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery.
European journal of haematology 2009;83(1):35-47.
2009: Jirina Hofmanová; Alena Vaculová; Zuzana Koubková; Martina Hýzd'alová; Alois Kozubík
Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs.
Molecular nutrition & food research 2009;53 Suppl 1():S102-13.
2008: Ján Kleban; Jaromir Mikes; Viktor Horváth; Veronika Sacková; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin.
Journal of photochemistry and photobiology. B, Biology 2008;93(2):108-18.
2008: M Hýzd'alová; Jirina Hofmanová; J Pacherník; Alena Vaculová; Alois Kozubík
The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: role of NF-kappaB activation.
Cytokine 2008;44(1):33-43.
2008: L Umannová; J Neca; Z Andrysík; Jan Vondrácek; B L Upham; James E Trosko; Jirina Hofmanová; Alois Kozubík; Miroslav Machala
Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling.
Toxicology 2008;247(1):55-60.
2008: Jirina Hofmanová; Alena Vaculová; Martina Hyzd'alová; Alois Kozubík
Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers.
Oncology reports 2008;19(2):567-73.
2008: Alois Kozubík; Alena Vaculová; Karel Soucek; Jan Vondrácek; Jaroslav Turánek; Jirina Hofmanová
Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism.
Metal-based drugs 2008;2008():417897.
2007: Viktor Horváth; Karel Soucek; Lenka Švihálková-Šindlerová; Jan Vondrácek; Olga Blanárová; Jirina Hofmanová; Petr Sova; Alois Kozubík
Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin.
Investigational new drugs 2007;25(5):435-43.
2007: Ján Kleban; Jaromir Mikes; Beáta Szilárdiová; Ján Kovaľ; Veronika Sacková; Peter Solár; Viktor Horváth; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells.
Photochemistry and photobiology 2007;83(5):1174-85.
2007: Jaromir Mikes; Ján Kleban; Veronika Sacková; Viktor Horváth; Erika Jamborová; Alena Vaculová; Alois Kozubík; Jirina Hofmanová; Peter Fedorocko
Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2007;6(7):758-66.
2006: Alena Vaculová; Jirina Hofmanová; Karel Soucek; Alois Kozubík
Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.
FEBS letters 2006;580(28-29):6565-9.
2006: Ján Kleban; Beáta Szilárdiová; Jaromir Mikes; Viktor Horváth; Veronika Sacková; Peter Brezáni; Jirina Hofmanová; Alois Kozubík; Peter Fedorocko
Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin.
Journal of photochemistry and photobiology. B, Biology 2006;84(2):79-88.
2006: Viktor Horváth; Olga Blanárová; Lenka Švihálková-Šindlerová; Karel Soucek; Jirina Hofmanová; Petr Sova; Ales Kroutil; Peter Fedorocko; Alois Kozubík
Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells.
Gynecologic oncology 2006;102(1):32-40.
2006: Jirí Stika; Jan Vondrácek; Jirina Hofmanová; Vladimír Simek; Alois Kozubík
MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis.
Cancer letters 2006;237(2):263-71.
2006: Karel Soucek; Jirí Pacherník; Lukas Kubala; Jan Vondrácek; Jirina Hofmanová; Alois Kozubík
Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis.
Leukemia research 2006;30(5):607-23.
2006: Zdenek Andrysík; Miroslav Machala; Katerina Chramostová; Jirina Hofmanová; Alois Kozubík; Jan Vondrácek
Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis.
Toxicology and applied pharmacology 2006;211(3):198-208.
2006: Jan Vondrácek; Karel Soucek; Michael A Sheard; Katerina Chramostová; Zdenek Andrysík; Jirina Hofmanová; Alois Kozubík
Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization.
Leukemia research 2006;30(1):81-9.
2005: Alena Vaculová; Jirina Hofmanová; Ladislav Andera; Alois Kozubík
TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death.
Cancer letters 2005;229(1):43-8.
2005: Eva Bártová; Jirí Pacherník; Andrea Harnicarová; Ales Kovarík; Martina Kovaríková; Jirina Hofmanová; Magdalena Skalníková; Michal Kozubek; Stanislav Kozubek
Nuclear levels and patterns of histone H3 modification and HP1 proteins after inhibition of histone deacetylases.
Journal of cell science 2005;118(Pt 21):5035-46.
2005: Alois Kozubík; Viktor Horváth; Lenka Švihálková-Šindlerová; Karel Soucek; Jirina Hofmanová; Petr Sova; Ales Kroutil; Frantisek Zák; Adolf Mistr; Jaroslav Turánek
High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro.
Biochemical pharmacology 2005;69(3):373-83.
2005: Jirina Hofmanová; Alena Vaculová; Antonín Lojek; Alois Kozubík
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells.
European journal of nutrition 2005;44(1):40-51.
2005: Jirina Hofmanová; Alena Vaculová; Alois Kozubík
Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis.
Cancer letters 2005;218(1):33-41.
2005: Jirina Hofmanová; Zdenek Zadák; Radomír Hyspler; J Mikeska; P Zdánský; Alena Vaculová; J Netíková; Alois Kozubík
The effects of parenteral lipid emulsions on cancer and normal human colon epithelial cells in vitro.
Physiological research / Academia Scientiarum Bohemoslovaca 2005;54(4):409-18.
2004: Alena Vaculová; Jirina Hofmanová; Karel Soucek; Ladislav Andera; Alois Kozubík
Ethanol acts as a potent agent sensitizing colon cancer cells to the TRAIL-induced apoptosis.
FEBS letters 2004;577(1-2):309-13.
2004: Martina Kovaríková; Jirina Hofmanová; Karel Soucek; Alois Kozubík
The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status.
Differentiation; research in biological diversity 2004;72(1):23-31.
2004: Zuzana Hoferová; Karel Soucek; Jirina Hofmanová; Michal Hofer; Katerina Chramostová; Peter Fedorocko; Alois Kozubik
In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase.
Cancer investigation 2004;22(2):234-47.
2003: Vítezslav Bryja; Jirí Sedlácek; Eva Zahradnícková; Sabina Sevcíková; Jirí Pacherník; Karel Soucek; Jirina Hofmanová; Alois Kozubík; Jan Smarda
Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.
Prostaglandins & other lipid mediators 2003;72(3-4):131-45.
2003: Jirí Fajkus; Marek Borsky; Zuzana Kunická; Martina Kovaríková; Dana Dvoráková; Jirina Hofmanová; Alois Kozubík
Changes in telomerase activity, expression and splicing in response to differentiation of normal and carcinoma colon cells.
Anticancer research 2003;23(2B):1605-12.
2003: Zuzana Hoferová; Peter Fedorocko; Michal Hofer; Jirina Hofmanová; Alois Kozubík; V Eliásová
Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.
Neoplasma 2003;50(2):102-9.
2002: Peter Solár; Ivan Cavarga; Jirina Hofmanová; Mária Cekanová-Figurová; Pavol Miskovský; Peter Brezáni; Gabriela Hrcková; Alois Kozubík; Peter Fedorocko
Effect of acetazolamide on hypericin photocytotoxicity.
Planta medica 2002;68(7):658-60.
2002: Jirí Pacherník; Ales Hampl; Karel Soucek; Martina Kovaríková; Zdenek Andrysík; Jirina Hofmanová; Alois Kozubík
Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes.
Archives of dermatological research 2002;293(12):626-33.
2002: Jirina Hofmanová; Karel Soucek; Jirí Pacherník; Martina Kovaríková; Zuzana Hoferová; Katerina Minksová; J Netíková; Alois Kozubík
Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle.
Neoplasma 2002;49(6):362-7.
2002: Jirí Pacherník; R Janík; Jirina Hofmanová; Vítezslav Bryja; Alois Kozubík
Conditions for gene transfection into the HL-60 human leukaemia cell line by electroporation.
Folia biologica 2002;48(4):154-6.
2002: Zuzana Hoferová; Peter Fedorocko; Jirina Hofmanová; Michal Hofer; Vladimír Znojil; Katerina Minksová; Karel Soucek; Alena Egyed; Alois Kozubík
The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma.
Cancer investigation 2002;20(4):490-8.
2001: Jan Vondrácek; J Stika; Karel Soucek; Katerina Minksová; Ludek Bláha; Jirina Hofmanová; Alois Kozubík
Inhibitors of arachidonic acid metabolism potentiate tumour necrosis factor-alpha-induced apoptosis in HL-60 cells.
European journal of pharmacology 2001;424(1):1-11.
2001: Jan Vondrácek; Miroslav Machala; Katerina Minksová; Ludek Bláha; A J Murk; Alois Kozubík; Jirina Hofmanová; Klára Hilscherová; Robert Ulrich; Miroslav Ciganek; Jirí Neca; D Svrcková; Ivan Holoubek
Monitoring river sediments contaminated predominantly with polyaromatic hydrocarbons by chemical and in vitro bioassay techniques.
Environmental toxicology and chemistry / SETAC 2001;20(7):1499-506.
2001: Jan Vondrácek; M A Sheard; P Krejcí; Katerina Minksová; Jirina Hofmanová; Alois Kozubík
Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells.
Journal of leukocyte biology 2001;69(5):794-802.
2001: Jirí Pacherník; Karel Soucek; Ales Hampl; Jirina Hofmanová; Alois Kozubík
Transforming growth factor-beta1 induces junB mRNA accumulation, G1-phase arrest, and pRb dephosphorylation in human leukemia HL-60 cells.
Folia biologica 2001;47(1):32-5.
2000: Martina Kovaríková; Jirí Pacherník; Jirina Hofmanová; Zdenek Zadák; Alois Kozubík
TNF-alpha modulates the differentiation induced by butyrate in the HT-29 human colon adenocarcinoma cell line.
European journal of cancer (Oxford, England : 1990) 2000;36(14):1844-52.
2000: Jan Zaloudík; O Coufal; I Kocáková; Alois Kozubík; Jirina Hofmanová
Chemoprevention of colorectal carcinoma in high-risk patients.
Acta Universitatis Palackianae Olomucensis Facultatis Medicae 2000;143():109.
2000: Jirina Hofmanová; Karel Soucek; L Dusek; J Netíková; Alois Kozubík
Inhibition of the cytochrome P-450 modulates all-trans-retinoic acid-induced differentiation and apoptosis of HL-60 cells.
Cancer detection and prevention 2000;24(4):325-42.
2000: Jirina Hofmanová; Miroslav Machala; Alois Kozubík
Epigenetic mechanisms of the carcinogenic effects of xenobiotics and in vitro methods of their detection.
Folia biologica 2000;46(5):165-73.
1999: Jan Smarda; K Zemanová; J Bryja; Jana Smardová; Alois Kozubík; Jirina Hofmanová; Alice Nemajerová; Sabina Sevcíková; Jirí Kohoutek; Petr Vodicka
Retinoid X receptor suppresses transformation by the v-myb oncogene.
Journal of leukocyte biology 1999;66(6):1039-48.
1998: Jirina Hofmanová; Alois Kozubík; L Dusek; Jirí Pacherník
Inhibitors of lipoxygenase metabolism exert synergistic effects with retinoic acid on differentiation of human leukemia HL-60 cells.
European journal of pharmacology 1998;350(2-3):273-84.
1997: Alois Kozubík; Jirina Hofmanová; L Dusek; E Musilová
5-Lipoxygenase inhibitors potentiate effects of TGF-beta 1 on the differentiation of human leukemia HL-60 cells.
Journal of leukocyte biology 1997;62(2):240-8.
1996: Alois Kozubík; Jirina Hofmanová; L Dusek
Eicosanoid inhibitors enhance synergistically the effect of transforming growth factor beta 1 on CCL 64 cell proliferation.
European journal of pharmacology 1996;316(2-3):349-57.
1996: Jirina Hofmanová; E Musilová; Alois Kozubík
Suppression of human cancer cell proliferation by lipoxygenase inhibitors and gamma-radiation in vitro.
General physiology and biophysics 1996;15(4):317-31.
1994: Alois Kozubík; Jirina Hofmanová; Milan Pospísil; J Netíková; Jirina Holá; Antonín Lojek
Effects of drugs inhibiting prostaglandin or leukotriene biosynthesis on postirradiation haematopoiesis in mouse.
International journal of radiation biology 1994;65(3):369-77.
1993: Antonín Lojek; Alois Kozubík; Milan Cíz; Jirina Hofmanová
Effects of nordihydroguaiaretic acid on the chemiluminescence of murine phagocytes.
General physiology and biophysics 1993;12(4):349-55.
1993: Alois Kozubík; Jirina Hofmanová; Jirina Holá; J Netíková
The effect of nordihydroguaiaretic acid, an inhibitor of prostaglandin and leukotriene biosynthesis, on hematopoiesis of gamma-irradiated mice.
Experimental hematology 1993;21(1):138-42.