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Leo Hofstra

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Johan Verjans; Sander Wolters; Ward Laufer; Mark Schellings; Michelle Lax; Dagfinn Lovhaug; Hendrikus H Boersma; Gerrit Kemerink; Simon Schalla; Paul Gordon; Jaap Teule; Jagat Narula; Leo Hofstra
Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging.
Reint K Jellema; Paul Bomans; Niko Deckers; Liset Ungethum; Chris P M Reutelingsperger; Leo Hofstra; Peter M Frederik
Transfection efficiency of lipoplexes for site-directed delivery.
Heidi Kenis; Harmen Reinier Zandbergen; Leo Hofstra; Artiom D Petrov; Ewald A W J Dumont; Francis D Blankenberg; Nezam Haider; Nicole Bitsch; Marion J J Gijbels; Johan W H Verjans; Navneet Narula; Jagat Narula; Chris P M Reutelingsperger
Annexin A5 uptake in ischemic myocardium: demonstration of reversible phosphatidylserine externalization and feasibility of radionuclide imaging.

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All Publications

2010: Johan Verjans; Sander Wolters; Ward Laufer; Mark Schellings; Michelle Lax; Dagfinn Lovhaug; Hendrikus H Boersma; Gerrit Kemerink; Simon Schalla; Paul Gordon; Jaap Teule; Jagat Narula; Leo Hofstra
Early molecular imaging of interstitial changes in patients after myocardial infarction: comparison with delayed contrast-enhanced magnetic resonance imaging.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2010;17(6):1065-72.
2010: Reint K Jellema; Paul Bomans; Niko Deckers; Liset Ungethum; Chris P M Reutelingsperger; Leo Hofstra; Peter M Frederik
Transfection efficiency of lipoplexes for site-directed delivery.
Journal of liposome research 2010;20(3):258-67.
2010: Heidi Kenis; Harmen Reinier Zandbergen; Leo Hofstra; Artiom D Petrov; Ewald A W J Dumont; Francis D Blankenberg; Nezam Haider; Nicole Bitsch; Marion J J Gijbels; Johan W H Verjans; Navneet Narula; Jagat Narula; Chris P M Reutelingsperger
Annexin A5 uptake in ischemic myocardium: demonstration of reversible phosphatidylserine externalization and feasibility of radionuclide imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010;51(2):259-67.
2010: Marijke De Saint-Hubert; Felix M Mottaghy; Kathleen Vunckx; Johan Nuyts; Humphrey Fonge; Kristof Prinsen; Sigrid Stroobants; Luc Mortelmans; Niko Deckers; Leo Hofstra; Chris P M Reutelingsperger; Alfons Verbruggen; Dirk Rattat
Site-specific labeling of 'second generation' annexin V with 99mTc(CO)3 for improved imaging of apoptosis in vivo.
Bioorganic & medicinal chemistry 2010;18(3):1356-63.
2010: Mark Schellings; Davy Vanhoutte; Geert C van Almen; Melissa Swinnen; Joost J G Leenders; Nard Kubben; Rick E W van Leeuwen; Leo Hofstra; Stephane Heymans; Yigal M Pinto
Syndecan-1 amplifies angiotensin II-induced cardiac fibrosis.
Hypertension 2010;55(2):249-56.
2010: Susanne W M van den Borne; Javier Diez; W Matthijs Blankesteijn; Johan Verjans; Leo Hofstra; Jagat Narula
Myocardial remodeling after infarction: the role of myofibroblasts.
Nature reviews. Cardiology 2010;7(1):30-7.
2009: Nezam Haider; Dagmar Hartung; Shinichiro Fujimoto; Artiom Petrov; Frank D Kolodgie; Renu Virmani; Satoru Ohshima; Han Liu; Jun Zhou; Ai Fujimoto; Atsuko Tahara; Leo Hofstra; Navneet Narula; Chris P M Reutelingsperger; Jagat Narula
Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2009;16(5):753-62.
2009: Harmen R Zandbergen; Umesh C Sharma; Sudhir Gupta; Johan W H Verjans; Susanne van den Borne; Saraswati Pokharel; Thomas van Brakel; Adriaan Duijvestijn; Nico van Rooijen; Jos G Maessen; Chris Reutelingsperger; Yigal M Pinto; Jagat Narula; Leo Hofstra
Macrophage depletion in hypertensive rats accelerates development of cardiomyopathy.
Journal of cardiovascular pharmacology and therapeutics 2009;14(1):68-75.
2009: Susanne W M van den Borne; Satoshi Isobe; H Reinier Zandbergen; Peng Li; Artiom Petrov; Nathan D Wong; Shinichiro Fujimoto; Ai Fujimoto; Dagfinn Lovhaug; Jos F M Smits; Mat J A P Daemen; W Matthijs Blankesteijn; Chris P M Reutelingsperger; Faiez Zannad; Navneet Narula; Mani A Vannan; Bertram Pitt; Leo Hofstra; Jagat Narula
Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling.
JACC. Cardiovascular imaging 2009;2(2):187-98.
2008: Susanne W M van den Borne; Satoshi Isobe; Johan W Verjans; Artiom Petrov; Dagfinn Lovhaug; Peng Li; H Reinier Zandbergen; Youping Ni; Peter Frederik; Jun Zhou; Bente Arbo; Astri Rogstad; Alan Cuthbertson; Salah Chettibi; Chris P M Reutelingsperger; W Matthijs Blankesteijn; Jos F M Smits; Mat J A P Daemen; Faiez Zannad; Mani A Vannan; Navneet Narula; Bertram Pitt; Leo Hofstra; Jagat Narula
Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction.
Journal of the American College of Cardiology 2008;52(24):2017-28.
2008: Hugo O van Genderen; Heidi Kenis; Leo Hofstra; Jagat Narula; Chris P M Reutelingsperger
Extracellular annexin A5: functions of phosphatidylserine-binding and two-dimensional crystallization.
Biochimica et biophysica acta 2008;1783(6):953-63.
2008: Edward M Laufer; Chris P M Reutelingsperger; Jagat Narula; Leo Hofstra
Annexin A5: an imaging biomarker of cardiovascular risk.
Basic research in cardiology 2008;103(2):95-104.
2007: Masayoshi Sarai; Dagmar Hartung; Artiom Petrov; Jun Zhou; Navneet Narula; Leo Hofstra; Frank D Kolodgie; Satoshi Isobe; Shinichiro Fujimoto; Jean-Luc Vanderheyden; Renu Virmani; Chris P M Reutelingsperger; Nathan D Wong; Sudhir Gupta; Jagat Narula
Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging.
Journal of the American College of Cardiology 2007;50(24):2305-12.
2007: Leo Hofstra; Stephane Heymans
Annexin A5 and the failing heart; lost or found in translation?
European heart journal 2007;28(22):2695-6.
2007: Heidi Kenis; Leo Hofstra; Chris P M Reutelingsperger
Annexin A5: shifting from a diagnostic towards a therapeutic realm.
Cellular and molecular life sciences : CMLS 2007;64(22):2859-62.
2007: S L Wolters; Maarten F Corsten; Chris P M Reutelingsperger; Jagat Narula; Leo Hofstra
Cardiovascular molecular imaging of apoptosis.
European journal of nuclear medicine and molecular imaging 2007;34 Suppl 1():S86-98.
2007: Dagmar Hartung; Michael Schäfers; Shinichiro Fujimoto; Bodo Levkau; Navneet Narula; Klaus Kopka; Renu Virmani; Chris P M Reutelingsperger; Leo Hofstra; Frank D Kolodgie; Artiom Petrov; Jagat Narula
Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions.
European journal of nuclear medicine and molecular imaging 2007;34 Suppl 1():S1-8.
2007: Bas L J H Kietselaer; Chris P M Reutelingsperger; Hendrikus H Boersma; Guido A K Heidendal; Ing Han Liem; Harry J G M Crijns; Jagat Narula; Leo Hofstra
Noninvasive detection of programmed cell loss with 99mTc-labeled annexin A5 in heart failure.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(4):562-7.
2007: Bas L J H Kietselaer; Jagat Narula; Leo Hofstra
The Annexin code: revealing endocarditis.
European heart journal 2007;28(8):948.
2007: Maarten F Corsten; Chris P M Reutelingsperger; Leo Hofstra
Imaging apoptosis for detecting plaque instability: rendering death a brighter facade.
Current opinion in biotechnology 2007;18(1):83-9.
2006: Alexandra Buehler; Marc A M J van Zandvoort; Bram J Stelt; Tilman M Hackeng; Bianca H G J Schrans-Stassen; Abdelkader Bennaghmouch; Leo Hofstra; Jack P M Cleutjens; Adriaan Duijvestijn; Mirjam B Smeets; Dominique P V de Kleijn; Mark J Post; Ebo D de Muinck
cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(12):2681-7.
2006: Satoshi Isobe; Sotirios Tsimikas; Jun Zhou; Shinichiro Fujimoto; Masayoshi Sarai; Michael J Branks; Ai Fujimoto; Leo Hofstra; Chris P M Reutelingsperger; Toyoaki Murohara; Renu Virmani; Frank D Kolodgie; Navneet Narula; Artiom Petrov; Jagat Narula
Noninvasive imaging of atherosclerotic lesions in apolipoprotein E-deficient and low-density-lipoprotein receptor-deficient mice with annexin A5.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(9):1497-505.
2006: Heidi Kenis; Hugo van Genderen; Niko Deckers; Petra Lux; Leo Hofstra; Jagat Narula; Chris P M Reutelingsperger
Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches.
Experimental cell research 2006;312(6):719-26.
2006: Kim van der Zander; Alphons J H M Houben; D J Webb; E Udo; Bas L J H Kietselaer; Leo Hofstra; Jo De Mey; Peter W de Leeuw
Selective endothelin B receptor blockade does not influence BNP-induced natriuresis in man.
Kidney international 2006;69(5):864-8.
2006: Maarten F Corsten; Leo Hofstra; Jagat Narula; Chris P M Reutelingsperger
Counting heads in the war against cancer: defining the role of annexin A5 imaging in cancer treatment and surveillance.
Cancer research 2006;66(3):1255-60.
2006: Hugo van Genderen; Heidi Kenis; Petra Lux; Lisette Ungeth; Cecile Maassen; Niko Deckers; Jagat Narula; Leo Hofstra; Chris P M Reutelingsperger
In vitro measurement of cell death with the annexin A5 affinity assay.
Nature protocols 2006;1(1):363-7.
2005: Dagmar Hartung; Masayoshi Sarai; Artiom Petrov; Frank D Kolodgie; Navneet Narula; Johan W Verjans; Renu Virmani; Chris P M Reutelingsperger; Leo Hofstra; Jagat Narula
Resolution of apoptosis in atherosclerotic plaque by dietary modification and statin therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(12):2051-6.
2005: Hendrikus H Boersma; Bas L J H Kietselaer; Leo M L Stolk; Abdelkader Bennaghmouch; Leo Hofstra; Jagat Narula; Guido A K Heidendal; Chris P M Reutelingsperger
Past, present, and future of annexin A5: from protein discovery to clinical applications.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(12):2035-50.
2005: Ronald B Driesen; Gerrit D Dispersyn; Fons K Verheyen; Stefan M van den Eijnde; Leo Hofstra; Fred Thoné; Petra Dijkstra; Wiel Debie; Marcel Borgers; Frans C S Ramaekers
Partial cell fusion: a newly recognized type of communication between dedifferentiating cardiomyocytes and fibroblasts.
Cardiovascular research 2005;68(1):37-46.
2005: Vanessa P M van Empel; Anne T Bertrand; Leo Hofstra; Harry J G M Crijns; Pieter A Doevendans; Leon J De Windt
Myocyte apoptosis in heart failure.
Cardiovascular research 2005;67(1):21-9.
2005: Dirk W Donker; Paul G A Volders; T Arts; B C A M Bekkers; Leo Hofstra; Roel L H M G Spätjens; Jet D M Beekman; M Borgers; Harry J G M Crijns; Marc A Vos
End-diastolic myofiber stress and ejection strain increase with ventricular volume overload--Serial in-vivo analyses in dogs with complete atrioventricular block.
Basic research in cardiology 2005;100(4):372-82.
2005: Sebastiaan C A M Bekkers; Jos H M Habets; Emile C Cheriex; Andrea Palmans; Yigal M Pinto; Leo Hofstra; Harry J G M Crijns
Abdominal aortic aneurysm screening during transthoracic echocardiography in an unselected population.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2005;18(5):389-93.
2005: Susana Ravassa; Abdelkader Bennaghmouch; Heidi Kenis; Theo Lindhout; Tilman M Hackeng; Jagat Narula; Leo Hofstra; Chris P M Reutelingsperger
Annexin A5 down-regulates surface expression of tissue factor: a novel mechanism of regulating the membrane receptor repertoir.
The Journal of biological chemistry 2005;280(7):6028-35.
2005: Hendrikus H Boersma; Selma C Tromp; Leo Hofstra; Jagat Narula
Stem cell tracking: reversing the silence of the lambs...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(2):200-3.
2004: Heidi Kenis; Hugo van Genderen; Abdelkader Bennaghmouch; Hilde A Rinia; Peter M Frederik; Jagat Narula; Leo Hofstra; Chris P M Reutelingsperger
Cell surface-expressed phosphatidylserine and annexin A5 open a novel portal of cell entry.
The Journal of biological chemistry 2004;279(50):52623-9.
2004: Bas L J H Kietselaer; Leo Hofstra; Jagat Narula
ACST: which subgroups will benefit most from carotid endarterectomy?
Lancet 2004;364(9440):1124-5; author reply 1125-6.
2004: Chris P M Reutelingsperger; Leo Hofstra; Jagat Narula
Cooking annexin V: a simple 1-pot procedure to destroy its phosphatidylserine-binding activity.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(6):1098; author reply 1098-9.
2004: Jagat Narula; Bas L J H Kietselaer; Leo Hofstra
Role of molecular imaging in defining and denying death...
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2004;11(3):349-57.
2004: Bas L J H Kietselaer; Chris P M Reutelingsperger; Guido A K Heidendal; Mat J A P Daemen; Werner H Mess; Leo Hofstra; Jagat Narula
Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis.
The New England journal of medicine 2004;350(14):1472-3.
2004: Hendrikus H Boersma; Leo M L Stolk; Heidi Kenis; Niko Deckers; Jean-Luc Vanderheyden; Leo Hofstra; Guido A K Heidendal; Chris P M Reutelingsperger
The ApoCorrect assay: a novel, rapid method to determine the biological functionality of radiolabeled and fluorescent Annexin A5.
Analytical biochemistry 2004;327(1):126-34.
2003: Frank D Kolodgie; Artiom Petrov; Renu Virmani; Navneet Narula; Johan W Verjans; Deena K Weber; Dagmar Hartung; Neil Steinmetz; Jean-Luc Vanderheyden; Mani A Vannan; Herman K Gold; Chris P M Reutelingsperger; Leo Hofstra; Jagat Narula
Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: a technique with potential for noninvasive imaging of vulnerable plaque.
Circulation 2003;108(25):3134-9.
2003: Bas L J H Kietselaer; Leo Hofstra; Ewald A W J Dumont; Chris P M Reutelingsperger; Guido A K Heidendal
The role of labeled Annexin A5 in imaging of programmed cell death. From animal to clinical imaging.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 2003;47(4):349-61.
2003: Alphons J H M Houben; Jeroen H Beljaars; Leo Hofstra; Abraham A Kroon; Peter W de Leeuw
Microvascular abnormalities in chronic heart failure: a cross-sectional analysis.
Microcirculation (New York, N.Y. : 1994) 2003;10(6):471-8.
2003: Shaila Garg; Leo Hofstra; Chris P M Reutelingsperger; Jagat Narula
Apoptosis as a therapeutic target in acutely ischemic myocardium.
Current opinion in cardiology 2003;18(5):372-7.
2003: Kim van der Zander; Alphons J H M Houben; Leo Hofstra; Abraham A Kroon; Peter W de Leeuw
Hemodynamic and renal effects of low-dose brain natriuretic peptide infusion in humans: a randomized, placebo-controlled crossover study.
American journal of physiology. Heart and circulatory physiology 2003;285(3):H1206-12.
2003: Hendrikus H Boersma; Ing Han Liem; Gerrit J Kemerink; Paul W L Thimister; Leo Hofstra; Leo M L Stolk; Waander L van Heerde; M-T W Pakbiers; D Janssen; AJ Beysens; Chris P M Reutelingsperger; Guido A K Heidendal
Comparison between human pharmacokinetics and imaging properties of two conjugation methods for 99mTc-annexin A5.
The British journal of radiology 2003;76(908):553-60.
2003: Paul W L Thimister; Leo Hofstra; Ing Han Liem; Hendrikus H Boersma; Gerrit J Kemerink; Chris P M Reutelingsperger; Guido A K Heidendal
In vivo detection of cell death in the area at risk in acute myocardial infarction.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(3):391-6.
2003: Ewald A W J Dumont; Chris P M Reutelingsperger; Guido A K Heidendal; Leo Hofstra
Bringing cell death alive.
Cardiovascular toxicology 2003;3(3):207-18.
2002: Chris P M Reutelingsperger; Ewald A W J Dumont; Paul W L Thimister; Hugo van Genderen; Heidi Kenis; Stefan van de Eijnde; Guido A K Heidendal; Leo Hofstra
Visualization of cell death in vivo with the annexin A5 imaging protocol.
Journal of immunological methods 2002;265(1-2):123-32.
2002: Leon J De Windt; K Cox; Leo Hofstra; Pieter A Doevendans
Molecular and genetic aspects of cardiac fatty acid homeostasis in health and disease.
European heart journal 2002;23(10):774-87.
2001: E A Dumont; Chris P M Reutelingsperger; Jos F M Smits; M J Daemen; Pieter A Doevendans; Hein J J Wellens; Leo Hofstra
Real-time imaging of apoptotic cell-membrane changes at the single-cell level in the beating murine heart.
Nature medicine 2001;7(12):1352-5.
2001: Gerrit J Kemerink; Hendrikus H Boersma; Paul W L Thimister; Leo Hofstra; Ing Han Liem; M-T W Pakbiers; D Janssen; Chris P M Reutelingsperger; Guido A K Heidendal
Biodistribution and dosimetry of 99mTc-BTAP-annexin-V in humans.
European journal of nuclear medicine 2001;28(9):1373-8.
2001: Leo Hofstra; Ewald A W J Dumont; Paul W L Thimister; Guido A K Heidendal; A P DeBruine; T W Elenbaas; Hendrikus H Boersma; Waander L van Heerde; Chris P M Reutelingsperger
In vivo detection of apoptosis in an intracardiac tumor.
JAMA : the journal of the American Medical Association 2001;285(14):1841-2.
2001: Gerrit J Kemerink; Ing Han Liem; Leo Hofstra; Hendrikus H Boersma; Wilhelmina C A M Buijs; Chris P M Reutelingsperger; Guido A K Heidendal
Patient dosimetry of intravenously administered 99mTc-annexin V.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(2):382-7.
2000: C Reutelingsperger; Leo Hofstra
Visualisation of cell death.
Lancet 2000;356(9246):2014.
2000: Ewald A W J Dumont; Leo Hofstra; Waander L van Heerde; Stefan M van den Eijnde; Pieter A Doevendans; E DeMuinck; M A Daemen; Jos F M Smits; Peter M Frederik; Hein J J Wellens; Mat J A P Daemen; Chris P M Reutelingsperger
Cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-V in a mouse model.
Circulation 2000;102(13):1564-8.
2000: Leo Hofstra; Ing Han Liem; Ewald A W J Dumont; Hendrikus H Boersma; Waander L van Heerde; Pieter A Doevendans; Ebo D de Muinck; Hein J J Wellens; Gerrit J Kemerink; Chris P M Reutelingsperger; Guido A K Heidendal
Visualisation of cell death in vivo in patients with acute myocardial infarction.
Lancet 2000;356(9225):209-12.
2000: Waander L van Heerde; S Robert-Offerman; Ewald A W J Dumont; Leo Hofstra; Pieter A Doevendans; Jos F M Smits; Mat J A P Daemen; Chris P M Reutelingsperger
Markers of apoptosis in cardiovascular tissues: focus on Annexin V.
Cardiovascular research 2000;45(3):549-59.