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David Holden

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TOP 3
Sophie Helaine; David W Holden
Heterogeneity of intracellular replication of bacterial pathogens.
Rita Figueira; David W Holden; Kathryn G Watson; Sophie Helaine
Identification of Salmonella Pathogenicity Island-2 Type III Secretion System Effectors Involved in Intramacrophage Replication of S. enterica Serovar Typhimurium: Implications for Rational Vaccine Design.
Francisco S Mesquita; David W Holden; Nathalie Rolhion
Lack of effect of the Salmonella deubiquitinase SseL on the NF-κB pathway.

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All Publications

2013: Sophie Helaine; David W Holden
Heterogeneity of intracellular replication of bacterial pathogens.
Current opinion in microbiology 2013;16(2):184-91.
2013: Rita Figueira; David W Holden; Kathryn G Watson; Sophie Helaine
Identification of Salmonella Pathogenicity Island-2 Type III Secretion System Effectors Involved in Intramacrophage Replication of S. enterica Serovar Typhimurium: Implications for Rational Vaccine Design.
mBio 2013;4(2):.
2013: Francisco S Mesquita; David W Holden; Nathalie Rolhion
Lack of effect of the Salmonella deubiquitinase SseL on the NF-κB pathway.
PloS one 2013;8(1):e53064.
2012: Mair Thomas; Francisco S Mesquita; David W Holden
The DUB-ious lack of ALIS in Salmonella infection: a Salmonella deubiquitinase regulates the autophagy of protein aggregates.
Autophagy 2012;8(12):1824-6.
2012: Kieran McGourty; Luís Jaime Mota; Laurie Pinaud; Teresa L Thurston; Sophie A Matthews; David W Holden
Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function.
Science (New York, N.Y.) 2012;338(6109):963-7.
2012: Charlotte Odendall; John Poh; Nathalie Rolhion; Douglas J Lamont; Mei Liu; Andrew D Catling; Andreas Förster; Paul S Freemont; David W Holden
The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton.
Cell host & microbe 2012;12(5):657-68.
2012: Anna E Dart; Sara K Donnelly; David W Holden; Michael Way; Emmanuelle Caron
Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis.
Journal of cell science 2012;125(Pt 12):2825-30.
2012: Rita Figueira; David W Holden
Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors.
Microbiology (Reading, England) 2012;158(Pt 5):1147-61.
2012: Francisco S Mesquita; Martin Sachse; António J M Santos; Mair Thomas; Rita Figueira; David W Holden
The Salmonella deubiquitinase SseL inhibits selective autophagy of cytosolic aggregates.
PLoS pathogens 2012;8(6):e1002743.
2011: Jessica A Thompson; Mei Liu; Sophie Helaine; David W Holden
Contribution of the PhoP/Q regulon to survival and replication of Salmonella enterica serovar Typhimurium in macrophages.
Microbiology (Reading, England) 2011;157(Pt 7):2084-93.
2010: Kathryn G Watson; David W Holden
Dynamics of growth and dissemination of Salmonella in vivo.
Cellular microbiology 2010;12(10):1389-97.
2010: Audrey Dumont; Emmanuel Boucrot; Stéphanie Drevensek; Vanessa Daire; Jean-Pierre Gorvel; Christian Pous; David W Holden; Stéphane Méresse
SKIP, the host target of the Salmonella virulence factor SifA, promotes kinesin-1-dependent vacuolar membrane exchanges.
Traffic (Copenhagen, Denmark) 2010;11(7):899-911.
2010: Xiu-Jun Yu; Kieran McGourty; Mei Liu; Kate E Unsworth; David W Holden
pH sensing by intracellular Salmonella induces effector translocation.
Science (New York, N.Y.) 2010;328(5981):1040-3.
2010: Sophie Helaine; Jessica A Thompson; Kathryn G Watson; Mei Liu; Cliona Boyle; David W Holden
Dynamics of intracellular bacterial replication at the single cell level.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3746-51.
2010: Eleanor Groves; Katrin Rittinger; Marlise Amstutz; Sara Berry; David W Holden; Guy R Cornelis; Emmanuelle Caron
Sequestering of Rac by the Yersinia effector YopO blocks Fcgamma receptor-mediated phagocytosis.
The Journal of biological chemistry 2010;285(6):4087-98.
2009: Luís Jaime Mota; Amy E Ramsden; Mei Liu; J David Castle; David W Holden
SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking.
Cellular microbiology 2009;11(8):1236-53.
2009: Mair Thomas; David W Holden
Ubiquitination - a bacterial effector's ticket to ride.
Cell host & microbe 2009;5(4):309-11.
2008: Nadine S Lossi; Nathalie Rolhion; Anthony I Magee; Cliona Boyle; David W Holden
The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid : cholesterol acyltransferase activity.
Microbiology (Reading, England) 2008;154(Pt 9):2680-8.
2008: Piotr Mazurkiewicz; Jerry Thomas; Jessica A Thompson; Mei Liu; Laurence Arbibe; Philippe Sansonetti; David W Holden
SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases.
Molecular microbiology 2008;67(6):1371-83.
2008: John Poh; Charlotte Odendall; Ad Spanos; Cliona Boyle; Mei Liu; Paul S Freemont; David W Holden
SteC is a Salmonella kinase required for SPI-2-dependent F-actin remodelling.
Cellular microbiology 2008;10(1):20-30.
2007: Amy E Ramsden; David W Holden; Luís Jaime Mota
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Trends in microbiology 2007;15(11):516-24.
2007: Amy E Ramsden; Luís Jaime Mota; Sylvia Münter; Spencer L Shorte; David W Holden
The SPI-2 type III secretion system restricts motility of Salmonella-containing vacuoles.
Cellular microbiology 2007;9(10):2517-29.
2007: Anne Rytkönen; David W Holden
Bacterial interference of ubiquitination and deubiquitination.
Cell host & microbe 2007;1(1):13-22.
2007: Anne Rytkönen; John Poh; juncal garmendia; Cliona Boyle; Arthur Thompson; Mei Liu; Paul S Freemont; Jay Hinton; David W Holden
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3502-7.
2007: Kate E Unsworth; Piotr Mazurkiewicz; Freya Senf; Markus Zettl; Mark McNiven; Michael Way; David W Holden
Dynamin is required for F-actin assembly and pedestal formation by enteropathogenic Escherichia coli (EPEC).
Cellular microbiology 2007;9(2):438-49.
2006: Piotr Mazurkiewicz; Christoph M Tang; Charles Boone; David W Holden
Signature-tagged mutagenesis: barcoding mutants for genome-wide screens.
Nature reviews. Genetics 2006;7(12):929-39.
2006: Jörg Deiwick; Suzana P Salcedo; Emmanuel Boucrot; Sarah M Gilliland; Thomas Henry; Nele Petermann; Scott R Waterman; Jean-Pierre Gorvel; David W Holden; Stéphane Méresse
The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.
Infection and immunity 2006;74(12):6965-72.
2006: Sofia Eriksson Ygberg; Mark O Clements; Anne Rytkönen; Arthur Thompson; David W Holden; Jay Hinton; Mikael Rhen
Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica.
Infection and immunity 2006;74(2):1243-54.
2005: Luís Jaime Mota; David W Holden
FlAsHlights on bacterial virulence proteins.
Nature methods 2005;2(12):898-9.
2005: Jose Yuste; Marina Botto; James C Paton; David W Holden; Jeremy S Brown
Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1813-9.
2005: Sheena A Linehan; Anne Rytkönen; Xiu-Jun Yu; Mei Liu; David W Holden
SlyA regulates function of Salmonella pathogenicity island 2 (SPI-2) and expression of SPI-2-associated genes.
Infection and immunity 2005;73(7):4354-62.
2005: Suzana P Salcedo; David W Holden
Bacterial interactions with the eukaryotic secretory pathway.
Current opinion in microbiology 2005;8(1):92-8.
2004: Xiu-Jun Yu; Mei Liu; David W Holden
SsaM and SpiC interact and regulate secretion of Salmonella pathogenicity island 2 type III secretion system effectors and translocators.
Molecular microbiology 2004;54(3):604-19.
2004: Liljana Petrovska; Richard Aspinall; Li Barber; Simon Clare; Cameron P Simmons; Richard Stratford; Shahid A Khan; Nick Lemoine; Gad Frankel; David W Holden; Gordon Dougan
Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene.
Cellular microbiology 2004;6(11):1071-84.
2004: Kate E Unsworth; Michael Way; Mark McNiven; Laura Machesky; David W Holden
Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication.
Cellular microbiology 2004;6(11):1041-55.
2004: Jeremy S Brown; Sarah M Gilliland; Shilpa Basavanna; David W Holden
phgABC, a three-gene operon required for growth of Streptococcus pneumoniae in hyperosmotic medium and in vivo.
Infection and immunity 2004;72(8):4579-88.
2004: Jeremy S Brown; Sarah M Gilliland; Brian G Spratt; David W Holden
A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice.
Infection and immunity 2004;72(3):1587-93.
2004: Julie Guignot; Emmanuelle Caron; Carmen R Beuzón; Cecilia Bucci; Jonathan Kagan; Craig Roy; David W Holden
Microtubule motors control membrane dynamics of Salmonella-containing vacuoles.
Journal of cell science 2004;117(Pt 7):1033-45.
2004: Miranda Batchelor; Julie Guignot; Amit Patel; Nicola Cummings; Jennifer Cleary; Stuart Knutton; David W Holden; Ian F Connerton; Gad Frankel
Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection.
EMBO reports 2004;5(1):104-10.
2003: Suzana P Salcedo; David W Holden
SseG, a virulence protein that targets Salmonella to the Golgi network.
The EMBO journal 2003;22(19):5003-14.
2003: juncal garmendia; Carmen R Beuzón; Javier Ruiz-Albert; David W Holden
The roles of SsrA-SsrB and OmpR-EnvZ in the regulation of genes encoding the Salmonella typhimurium SPI-2 type III secretion system.
Microbiology (Reading, England) 2003;149(Pt 9):2385-96.
2003: Francisco Ramos-Morales; Ana I Prieto; Carmen R Beuzón; David W Holden; Josep Casadesús
Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence.
Journal of bacteriology 2003;185(17):5328-32.
2003: Scott R Waterman; David W Holden
Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system.
Cellular microbiology 2003;5(8):501-11.
2003: Javier Ruiz-Albert; Rosanna Mundy; Xiu-Jun Yu; Carmen R Beuzón; David W Holden
SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system.
Microbiology (Reading, England) 2003;149(Pt 5):1103-11.
2003: Emmanuel Boucrot; Carmen R Beuzón; David W Holden; Jean-Pierre Gorvel; Stéphane Méresse
Salmonella typhimurium SifA effector protein requires its membrane-anchoring C-terminal hexapeptide for its biological function.
The Journal of biological chemistry 2003;278(16):14196-202.
2003: Sheena A Linehan; David W Holden
The interplay between Salmonella typhimurium and its macrophage host--what can it teach us about innate immunity?
Immunology letters 2003;85(2):183-92.
2002: Jeremy S Brown; Tracy Hussell; Sarah M Gilliland; David W Holden; James C Paton; Michael R Ehrenstein; Mark J Walport; Marina Botto
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16969-74.
2002: steve garvis; Ji-Min Mei; Javier Ruiz-Albert; David W Holden
Staphylococcus aureus svrA: a gene required for virulence and expression of the agr locus.
Microbiology (Reading, England) 2002;148(Pt 10):3235-43.
2002: Jeremy S Brown; David W Holden
Iron acquisition by Gram-positive bacterial pathogens.
Microbes and infection / Institut Pasteur 2002;4(11):1149-56.
2002: Carmen R Beuzón; Suzana P Salcedo; David W Holden
Growth and killing of a Salmonella enterica serovar Typhimurium sifA mutant strain in the cytosol of different host cell lines.
Microbiology (Reading, England) 2002;148(Pt 9):2705-15.
2002: Xiu-Jun Yu; Javier Ruiz-Albert; Kate E Unsworth; steve garvis; Mei Liu; David W Holden
SpiC is required for secretion of Salmonella Pathogenicity Island 2 type III secretion system proteins.
Cellular microbiology 2002;4(8):531-40.
2002: Jeremy S Brown; Sarah M Gilliland; Javier Ruiz-Albert; David W Holden
Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter.
Infection and immunity 2002;70(8):4389-98.
2002: Zoë Hindle; Steven N Chatfield; Jo Phillimore; Matthew Bentley; Julie Johnson; Catherine Cosgrove; Marjan Ghaem-Maghami; Amy Sexton; Mohammad Khan; Frank R Brennan; Paul Everest; Tao Wu; Derek Pickard; David W Holden; Gordon Dougan; George E Griffin; Deborah House; Joseph D Santangelo; Shahid A Khan; Jaqueline E Shea; Robert G Feldman; David J M Lewis
Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers.
Infection and immunity 2002;70(7):3457-67.
2002: Javier Ruiz-Albert; Xiu-Jun Yu; Carmen R Beuzón; Abigail N Blakey; Edouard E Galyov; David W Holden
Complementary activities of SseJ and SifA regulate dynamics of the Salmonella typhimurium vacuolar membrane.
Molecular microbiology 2002;44(3):645-61.
2002: David W Holden
Trafficking of the Salmonella vacuole in macrophages.
Traffic (Copenhagen, Denmark) 2002;3(3):161-9.
2001: Carmen R Beuzón; Kate E Unsworth; David W Holden
In vivo genetic analysis indicates that PhoP-PhoQ and the Salmonella pathogenicity island 2 type III secretion system contribute independently to Salmonella enterica serovar Typhimurium virulence.
Infection and immunity 2001;69(12):7254-61.
2001: Carmen R Beuzón; David W Holden
Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo.
Microbes and infection / Institut Pasteur 2001;3(14-15):1345-52.
2001: steve garvis; Carmen R Beuzón; David W Holden
A role for the PhoP/Q regulon in inhibition of fusion between lysosomes and Salmonella-containing vacuoles in macrophages.
Cellular microbiology 2001;3(11):731-44.
2001: Jeremy S Brown; A David Ogunniyi; MC Woodrow; David W Holden; James C Paton
Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection.
Infection and immunity 2001;69(11):6702-6.
2001: J L Webb; M W Harvey; David W Holden; T J Evans
Macrophage nitric oxide synthase associates with cortical actin but is not recruited to phagosomes.
Infection and immunity 2001;69(10):6391-400.
2001: Suzana P Salcedo; M Noursadeghi; J Cohen; David W Holden
Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo.
Cellular microbiology 2001;3(9):587-97.
2001: Stéphane Méresse; Kate E Unsworth; A Habermann; G Griffiths; F Fang; MJ Martínez-Lorenzo; S R Waterman; Jean-Pierre Gorvel; David W Holden
Remodelling of the actin cytoskeleton is essential for replication of intravacuolar Salmonella.
Cellular microbiology 2001;3(8):567-77.
2001: Jeremy S Brown; Sarah M Gilliland; David W Holden
A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence.
Molecular microbiology 2001;40(3):572-85.
2001: G W Lau; S Haataja; Michael Lonetto; S E Kensit; A Marra; AP Bryant; Damien McDevitt; Donald A Morrison; David W Holden
A functional genomic analysis of type 3 Streptococcus pneumoniae virulence.
Molecular microbiology 2001;40(3):555-71.
2000: Carmen R Beuzón; Stéphane Méresse; Kate E Unsworth; J Ruíz-Albert; steve garvis; S R Waterman; Timothy A Ryder; Emmanuel Boucrot; David W Holden
Salmonella maintains the integrity of its intracellular vacuole through the action of SifA.
The EMBO journal 2000;19(13):3235-49.
2000: Jeremy S Brown; A Aufauvre-Brown; J Brown; J M Jennings; Herbert N Arst; David W Holden
Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity.
Molecular microbiology 2000;36(6):1371-80.
2000: Kate E Unsworth; David W Holden
Identification and analysis of bacterial virulence genes in vivo.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1397):613-22.
2000: Andrés Vazquez-Torres; Yisheng Xu; Jessica Jones-Carson; David W Holden; Scott Lucia; MC Dinauer; Pietro Mastroeni; Ferric C Fang
Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.
Science (New York, N.Y.) 2000;287(5458):1655-8.
1999: Carmen R Beuzón; G Banks; Jörg Deiwick; Michael Hensel; David W Holden
pH-dependent secretion of SseB, a product of the SPI-2 type III secretion system of Salmonella typhimurium.
Molecular microbiology 1999;33(4):806-16.
1999: Valerie A Snewin; David W Holden
Signs and portents: molecular signals and infectious diseases.
Trends in microbiology 1999;7(2):62-4.
1999: Jaqueline E Shea; C R Beuzon; C Gleeson; Rosanna Mundy; David W Holden
Influence of the Salmonella typhimurium pathogenicity island 2 type III secretion system on bacterial growth in the mouse.
Infection and immunity 1999;67(1):213-9.
1998: A Aufauvre-Brown; Jeremy S Brown; David W Holden
Comparison of virulence between clinical and environmental isolates of Aspergillus fumigatus.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1998;17(11):778-80.
1998: Michael Hensel; Jaqueline E Shea; S R Waterman; Rosanna Mundy; T Nikolaus; G Banks; Andrés Vazquez-Torres; C Gleeson; Ferric C Fang; David W Holden
Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages.
Molecular microbiology 1998;30(1):163-74.
1998: Jörg Deiwick; T Nikolaus; Jaqueline E Shea; C Gleeson; David W Holden; Michael Hensel
Mutations in Salmonella pathogenicity island 2 (SPI2) genes affecting transcription of SPI1 genes and resistance to antimicrobial agents.
Journal of bacteriology 1998;180(18):4775-80.
1998: J S Brown; David W Holden
Insertional mutagenesis of pathogenic fungi.
Current opinion in microbiology 1998;1(4):390-4.
1998: R Kao; Jaqueline E Shea; J Davies; David W Holden
Probing the active site of mitogillin, a fungal ribotoxin.
Molecular microbiology 1998;29(4):1019-27.
1998: Jeremy S Brown; A Aufauvre-Brown; David W Holden
Insertional mutagenesis of Aspergillus fumigatus.
Molecular & general genetics : MGG 1998;259(3):327-35.
1998: M Hensel; Herbert N Arst; A Aufauvre-Brown; David W Holden
The role of the Aspergillus fumigatus areA gene in invasive pulmonary aspergillosis.
Molecular & general genetics : MGG 1998;258(5):553-7.
1997: J M Mei; F Nourbakhsh; C W Ford; David W Holden
Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis.
Molecular microbiology 1997;26(2):399-407.
1997: Michael Hensel; Jaqueline E Shea; B Raupach; Denise M Monack; S Falkow; C Gleeson; T Kubo; David W Holden
Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2.
Molecular microbiology 1997;24(1):155-67.
1997: A Aufauvre-Brown; E Mellado; N A Gow; David W Holden
Aspergillus fumigatus chsE: a gene related to CHS3 of Saccharomyces cerevisiae and important for hyphal growth and conidiophore development but not pathogenicity.
Fungal genetics and biology : FG & B 1997;21(1):141-52.
1997: Michael Hensel; Jaqueline E Shea; Andreas J Baumler; C Gleeson; F Blattner; David W Holden
Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12.
Journal of bacteriology 1997;179(4):1105-11.
1996: E Mellado; C A Specht; P W Robbins; David W Holden
Cloning and characterization of chsD, a chitin synthase-like gene of Aspergillus fumigatus.
FEMS microbiology letters 1996;143(1):69-76.
1996: E Mellado; A Aufauvre-Brown; N A Gow; David W Holden
The Aspergillus fumigatus chsC and chsG genes encode class III chitin synthases with different functions.
Molecular microbiology 1996;20(3):667-79.
1996: Michael Hensel; David W Holden
Molecular genetic approaches for the study of virulence in both pathogenic bacteria and fungi.
Microbiology (Reading, England) 1996;142 ( Pt 5)():1049-58.
1996: Jaqueline E Shea; Michael Hensel; C Gleeson; David W Holden
Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2593-7.
1995: Michael Hensel; Jaqueline E Shea; C Gleeson; M D Jones; Emma Dalton; David W Holden
Simultaneous identification of bacterial virulence genes by negative selection.
Science (New York, N.Y.) 1995;269(5222):400-3.
1995: E Mellado; A Aufauvre-Brown; C A Specht; P W Robbins; David W Holden
A multigene family related to chitin synthase genes of yeast in the opportunistic pathogen Aspergillus fumigatus.
Molecular & general genetics : MGG 1995;246(3):353-9.
1994: C M Tang; J M Smith; Herbert N Arst; David W Holden
Virulence studies of Aspergillus nidulans mutants requiring lysine or p-aminobenzoic acid in invasive pulmonary aspergillosis.
Infection and immunity 1994;62(12):5255-60.
1994: J M Smith; C M Tang; S Van Noorden; David W Holden
Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis.
Infection and immunity 1994;62(12):5247-54.
1994: C M Tang; Jon Cohen; A J Rees; David W Holden
Molecular epidemiological study of invasive pulmonary aspergillosis in a renal transplantation unit.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1994;13(4):318-21.
1994: David W Holden; C M Tang; J M Smith
Molecular genetics of Aspergillus pathogenicity.
Antonie van Leeuwenhoek 1994;65(3):251-5.
1993: C M Tang; David W Holden; A Aufauvre-Brown; Jon Cohen
The detection of Aspergillus spp. by the polymerase chain reaction and its evaluation in bronchoalveolar lavage fluid.
The American review of respiratory disease 1993;148(5):1313-7.
1993: J M Smith; J E Davies; David W Holden
Construction and pathogenicity of Aspergillus fumigatus mutants that do not produce the ribotoxin restrictocin.
Molecular microbiology 1993;9(5):1071-7.
1993: A Aufauvre-Brown; C M Tang; David W Holden
Detection of gene-disruption events in Aspergillus transformants by polymerase chain reaction direct from conidiospores.
Current genetics 1993;24(1-2):177-8.
1993: C M Tang; Jon Cohen; Thomas Krausz; S Van Noorden; David W Holden
The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis.
Infection and immunity 1993;61(5):1650-6.
1992: A Aufauvre-Brown; Jon Cohen; David W Holden
Use of randomly amplified polymorphic DNA markers to distinguish isolates of Aspergillus fumigatus.
Journal of clinical microbiology 1992;30(11):2991-3.
1992: C M Tang; Jon Cohen; David W Holden
An Aspergillus fumigatus alkaline protease mutant constructed by gene disruption is deficient in extracellular elastase activity.
Molecular microbiology 1992;6(12):1663-71.