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David Holden

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Mota Luís Jaime; Ramsden Amy E; Liu Mei; Castle J David; Holden David W
SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking.
Thomas Mair; Holden David W
Ubiquitination - a bacterial effector's ticket to ride.
Lossi Nadine S; Rolhion Nathalie; Magee Anthony I; Boyle Cliona; Holden David W
The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid : cholesterol acyltransferase activity.

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All Publications

2009: Mota Luís Jaime; Ramsden Amy E; Liu Mei; Castle J David; Holden David W
SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking.
Cellular microbiology 2009;11(8):1236-53.
2009: Thomas Mair; Holden David W
Ubiquitination - a bacterial effector's ticket to ride.
Cell host & microbe 2009;5(4):309-11.
2008: Lossi Nadine S; Rolhion Nathalie; Magee Anthony I; Boyle Cliona; Holden David W
The Salmonella SPI-2 effector SseJ exhibits eukaryotic activator-dependent phospholipase A and glycerophospholipid : cholesterol acyltransferase activity.
Microbiology (Reading, England) 2008;154(Pt 9):2680-8.
2008: Mazurkiewicz Piotr; Thomas Jerry; Thompson Jessica A; Liu Mei; Arbibe Laurence; Sansonetti Philippe; Holden David W
SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases.
Molecular microbiology 2008;67(6):1371-83.
2008: Poh John; Odendall Charlotte; Spanos Ad; Boyle Cliona; Liu Mei; Freemont Paul; Holden David W
SteC is a Salmonella kinase required for SPI-2-dependent F-actin remodelling.
Cellular microbiology 2008;10(1):20-30.
2007: Ramsden Amy E; Holden David W; Mota Luís J
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Trends in microbiology 2007;15(11):516-24.
2007: Ramsden Amy E; Mota Luís J; Münter Sylvia; Shorte Spencer L; Holden David W
The SPI-2 type III secretion system restricts motility of Salmonella-containing vacuoles.
Cellular microbiology 2007;9(10):2517-29.
2007: Rytkönen Anne; Holden David W
Bacterial interference of ubiquitination and deubiquitination.
Cell host & microbe 2007;1(1):13-22.
2007: Rytkönen Anne; Poh John; Garmendia Junkal; Boyle Cliona; Thompson Arthur; Liu Mei; Freemont Paul; Hinton Jay C D; Holden David W
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3502-7.
2007: Unsworth Kate E; Mazurkiewicz Piotr; Senf Freya; Zettl Markus; McNiven Mark; Way Michael; Holden David W
Dynamin is required for F-actin assembly and pedestal formation by enteropathogenic Escherichia coli (EPEC).
Cellular microbiology 2007;9(2):438-49.
2006: Mazurkiewicz Piotr; Tang Christoph M; Boone Charles; Holden David W
Signature-tagged mutagenesis: barcoding mutants for genome-wide screens.
Nature reviews. Genetics 2006;7(12):929-39.
2006: Deiwick Jörg; Salcedo Suzana P; Boucrot Emmanuel; Gilliland Sarah M; Henry Thomas; Petermann Nele; Waterman Scott R; Gorvel Jean-Pierre; Holden David W; Méresse Stéphane
The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.
Infection and immunity 2006;74(12):6965-72.
2006: Ygberg Sofia Eriksson; Clements Mark O; Rytkönen Anne; Thompson Arthur; Holden David W; Hinton Jay C D; Rhen Mikael
Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica.
Infection and immunity 2006;74(2):1243-54.
2005: Mota Luís Jaime; Holden David W
FlAsHlights on bacterial virulence proteins.
Nature methods 2005;2(12):898-9.
2005: Yuste Jose; Botto Marina; Paton James C; Holden David W; Brown Jeremy S
Additive inhibition of complement deposition by pneumolysin and PspA facilitates Streptococcus pneumoniae septicemia.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(3):1813-9.
2005: Linehan Sheena A; Rytkönen Anne; Yu Xiu-Jun; Liu Mei; Holden David W
SlyA regulates function of Salmonella pathogenicity island 2 (SPI-2) and expression of SPI-2-associated genes.
Infection and immunity 2005;73(7):4354-62.
2005: Salcedo Suzana P; Holden David W
Bacterial interactions with the eukaryotic secretory pathway.
Current opinion in microbiology 2005;8(1):92-8.
2004: Yu Xiu-Jun; Liu Mei; Holden David W
SsaM and SpiC interact and regulate secretion of Salmonella pathogenicity island 2 type III secretion system effectors and translocators.
Molecular microbiology 2004;54(3):604-19.
2004: Petrovska Liljana; Aspinall Richard J; Barber Li; Clare Simon; Simmons Cameron P; Stratford Richard; Khan Shahid A; Lemoine Nicholas R; Frankel Gad; Holden David W; Dougan Gordon
Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene.
Cellular microbiology 2004;6(11):1071-84.
2004: Unsworth Kate E; Way Michael; McNiven Mark; Machesky Laura; Holden David W
Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication.
Cellular microbiology 2004;6(11):1041-55.
2004: Brown Jeremy S; Gilliland Sarah M; Basavanna Shilpa; Holden David W
phgABC, a three-gene operon required for growth of Streptococcus pneumoniae in hyperosmotic medium and in vivo.
Infection and immunity 2004;72(8):4579-88.
2004: Brown Jeremy S; Gilliland Sarah M; Spratt Brian G; Holden David W
A locus contained within a variable region of pneumococcal pathogenicity island 1 contributes to virulence in mice.
Infection and immunity 2004;72(3):1587-93.
2004: Guignot Julie; Caron Emmanuelle; Beuzón Carmen; Bucci Cecilia; Kagan Jonathan; Roy Craig; Holden David W
Microtubule motors control membrane dynamics of Salmonella-containing vacuoles.
Journal of cell science 2004;117(Pt 7):1033-45.
2004: Batchelor Miranda; Guignot Julie; Patel Amit; Cummings Nicola; Cleary Jennifer; Knutton Stuart; Holden David W; Connerton Ian; Frankel Gad
Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infection.
EMBO reports 2004;5(1):104-10.
2003: Salcedo Suzana P; Holden David W
SseG, a virulence protein that targets Salmonella to the Golgi network.
The EMBO journal 2003;22(19):5003-14.
2003: Garmendia Junkal; Beuzón Carmen R; Ruiz-Albert Javier; Holden David W
The roles of SsrA-SsrB and OmpR-EnvZ in the regulation of genes encoding the Salmonella typhimurium SPI-2 type III secretion system.
Microbiology (Reading, England) 2003;149(Pt 9):2385-96.
2003: Ramos-Morales Francisco; Prieto Ana I; Beuzón Carmen R; Holden David W; Casadesús Josep
Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence.
Journal of bacteriology 2003;185(17):5328-32.
2003: Waterman Scott R; Holden David W
Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system.
Cellular microbiology 2003;5(8):501-11.
2003: Ruiz-Albert Javier; Mundy Rosanna; Yu Xiu-Jun; Beuzón Carmen R; Holden David W
SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system.
Microbiology (Reading, England) 2003;149(Pt 5):1103-11.
2003: Boucrot Emmanuel; Beuzón Carmen R; Holden David W; Gorvel Jean-Pierre; Méresse Stéphane
Salmonella typhimurium SifA effector protein requires its membrane-anchoring C-terminal hexapeptide for its biological function.
The Journal of biological chemistry 2003;278(16):14196-202.
2003: Linehan Sheena A; Holden David W
The interplay between Salmonella typhimurium and its macrophage host--what can it teach us about innate immunity?
Immunology letters 2003;85(2):183-92.
2002: Brown Jeremy S; Hussell Tracy; Gilliland Sarah M; Holden David W; Paton James C; Ehrenstein Michael R; Walport Mark J; Botto Marina
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16969-74.
2002: Garvis Steve; Mei Ji-Min; Ruiz-Albert Javier; Holden David W
Staphylococcus aureus svrA: a gene required for virulence and expression of the agr locus.
Microbiology (Reading, England) 2002;148(Pt 10):3235-43.
2002: Brown Jeremy S; Holden David W
Iron acquisition by Gram-positive bacterial pathogens.
Microbes and infection / Institut Pasteur 2002;4(11):1149-56.
2002: Beuzón Carmen R; Salcedo Suzana P; Holden David W
Growth and killing of a Salmonella enterica serovar Typhimurium sifA mutant strain in the cytosol of different host cell lines.
Microbiology (Reading, England) 2002;148(Pt 9):2705-15.
2002: Yu Xiu-Jun; Ruiz-Albert Javier; Unsworth Kate E; Garvis Steven; Liu Mei; Holden David W
SpiC is required for secretion of Salmonella Pathogenicity Island 2 type III secretion system proteins.
Cellular microbiology 2002;4(8):531-40.
2002: Brown Jeremy S; Gilliland Sarah M; Ruiz-Albert Javier; Holden David W
Characterization of pit, a Streptococcus pneumoniae iron uptake ABC transporter.
Infection and immunity 2002;70(8):4389-98.
2002: Hindle Zoë; Chatfield Steven N; Phillimore Jo; Bentley Matthew; Johnson Julie; Cosgrove Catherine A; Ghaem-Maghami Marjan; Sexton Amy; Khan Mohammad; Brennan Frank R; Everest Paul; Wu Tao; Pickard Derek; Holden David W; Dougan Gordon; Griffin George E; House Deborah; Santangelo Joseph D; Khan Shahid A; Shea Jaqueline E; Feldman Robert G; Lewis David J M
Characterization of Salmonella enterica derivatives harboring defined aroC and Salmonella pathogenicity island 2 type III secretion system (ssaV) mutations by immunization of healthy volunteers.
Infection and immunity 2002;70(7):3457-67.
2002: Ruiz-Albert Javier; Yu Xiu-Jun; Beuzón Carmen R; Blakey Abigail N; Galyov Edouard E; Holden David W
Complementary activities of SseJ and SifA regulate dynamics of the Salmonella typhimurium vacuolar membrane.
Molecular microbiology 2002;44(3):645-61.
2002: Holden David W
Trafficking of the Salmonella vacuole in macrophages.
Traffic (Copenhagen, Denmark) 2002;3(3):161-9.
2001: Beuzón C R; Unsworth K E; Holden D W
In vivo genetic analysis indicates that PhoP-PhoQ and the Salmonella pathogenicity island 2 type III secretion system contribute independently to Salmonella enterica serovar Typhimurium virulence.
Infection and immunity 2001;69(12):7254-61.
2001: Beuzón C R; Holden D W
Use of mixed infections with Salmonella strains to study virulence genes and their interactions in vivo.
Microbes and infection / Institut Pasteur 2001;3(14-15):1345-52.
2001: Garvis S G; Beuzón C R; Holden D W
A role for the PhoP/Q regulon in inhibition of fusion between lysosomes and Salmonella-containing vacuoles in macrophages.
Cellular microbiology 2001;3(11):731-44.
2001: Brown J S; Ogunniyi A D; Woodrow M C; Holden D W; Paton J C
Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection.
Infection and immunity 2001;69(11):6702-6.
2001: Webb J L; Harvey M W; Holden D W; Evans T J
Macrophage nitric oxide synthase associates with cortical actin but is not recruited to phagosomes.
Infection and immunity 2001;69(10):6391-400.
2001: Salcedo S P; Noursadeghi M; Cohen J; Holden D W
Intracellular replication of Salmonella typhimurium strains in specific subsets of splenic macrophages in vivo.
Cellular microbiology 2001;3(9):587-97.
2001: Méresse S; Unsworth K E; Habermann A; Griffiths G; Fang F; Martínez-Lorenzo M J; Waterman S R; Gorvel J P; Holden D W
Remodelling of the actin cytoskeleton is essential for replication of intravacuolar Salmonella.
Cellular microbiology 2001;3(8):567-77.
2001: Brown J S; Gilliland S M; Holden D W
A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence.
Molecular microbiology 2001;40(3):572-85.
2001: Lau G W; Haataja S; Lonetto M; Kensit S E; Marra A; Bryant A P; McDevitt D; Morrison D A; Holden D W
A functional genomic analysis of type 3 Streptococcus pneumoniae virulence.
Molecular microbiology 2001;40(3):555-71.
2000: Beuzón C R; Méresse S; Unsworth K E; Ruíz-Albert J; Garvis S; Waterman S R; Ryder T A; Boucrot E; Holden D W
Salmonella maintains the integrity of its intracellular vacuole through the action of SifA.
The EMBO journal 2000;19(13):3235-49.
2000: Brown J S; Aufauvre-Brown A; Brown J; Jennings J M; Arst H; Holden D W
Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity.
Molecular microbiology 2000;36(6):1371-80.
2000: Unsworth K E; Holden D W
Identification and analysis of bacterial virulence genes in vivo.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2000;355(1397):613-22.
2000: Vazquez-Torres A; Xu Y; Jones-Carson J; Holden D W; Lucia S M; Dinauer M C; Mastroeni P; Fang F C
Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.
Science (New York, N.Y.) 2000;287(5458):1655-8.
1999: Beuzón C R; Banks G; Deiwick J; Hensel M; Holden D W
pH-dependent secretion of SseB, a product of the SPI-2 type III secretion system of Salmonella typhimurium.
Molecular microbiology 1999;33(4):806-16.
1999: Snewin V A; Holden D W
Signs and portents: molecular signals and infectious diseases.
Trends in microbiology 1999;7(2):62-4.
1999: Shea J E; Beuzon C R; Gleeson C; Mundy R; Holden D W
Influence of the Salmonella typhimurium pathogenicity island 2 type III secretion system on bacterial growth in the mouse.
Infection and immunity 1999;67(1):213-9.
1998: Aufauvre-Brown A; Brown J S; Holden D W
Comparison of virulence between clinical and environmental isolates of Aspergillus fumigatus.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1998;17(11):778-80.
1998: Hensel M; Shea J E; Waterman S R; Mundy R; Nikolaus T; Banks G; Vazquez-Torres A; Gleeson C; Fang F C; Holden D W
Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophages.
Molecular microbiology 1998;30(1):163-74.
1998: Deiwick J; Nikolaus T; Shea J E; Gleeson C; Holden D W; Hensel M
Mutations in Salmonella pathogenicity island 2 (SPI2) genes affecting transcription of SPI1 genes and resistance to antimicrobial agents.
Journal of bacteriology 1998;180(18):4775-80.
1998: Brown J S; Holden D W
Insertional mutagenesis of pathogenic fungi.
Current opinion in microbiology 1998;1(4):390-4.
1998: Kao R; Shea J E; Davies J; Holden D W
Probing the active site of mitogillin, a fungal ribotoxin.
Molecular microbiology 1998;29(4):1019-27.
1998: Brown J S; Aufauvre-Brown A; Holden D W
Insertional mutagenesis of Aspergillus fumigatus.
Molecular & general genetics : MGG 1998;259(3):327-35.
1998: Hensel M; Arst H N; Aufauvre-Brown A; Holden D W
The role of the Aspergillus fumigatus areA gene in invasive pulmonary aspergillosis.
Molecular & general genetics : MGG 1998;258(5):553-7.
1997: Mei J M; Nourbakhsh F; Ford C W; Holden D W
Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis.
Molecular microbiology 1997;26(2):399-407.
1997: Hensel M; Shea J E; Raupach B; Monack D; Falkow S; Gleeson C; Kubo T; Holden D W
Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2.
Molecular microbiology 1997;24(1):155-67.
1997: Aufauvre-Brown A; Mellado E; Gow N A; Holden D W
Aspergillus fumigatus chsE: a gene related to CHS3 of Saccharomyces cerevisiae and important for hyphal growth and conidiophore development but not pathogenicity.
Fungal genetics and biology : FG & B 1997;21(1):141-52.
1997: Hensel M; Shea J E; Bäumler A J; Gleeson C; Blattner F; Holden D W
Analysis of the boundaries of Salmonella pathogenicity island 2 and the corresponding chromosomal region of Escherichia coli K-12.
Journal of bacteriology 1997;179(4):1105-11.
1996: Mellado E; Specht C A; Robbins P W; Holden D W
Cloning and characterization of chsD, a chitin synthase-like gene of Aspergillus fumigatus.
FEMS microbiology letters 1996;143(1):69-76.
1996: Mellado E; Aufauvre-Brown A; Gow N A; Holden D W
The Aspergillus fumigatus chsC and chsG genes encode class III chitin synthases with different functions.
Molecular microbiology 1996;20(3):667-79.
1996: Hensel M; Holden D W
Molecular genetic approaches for the study of virulence in both pathogenic bacteria and fungi.
Microbiology (Reading, England) 1996;142 ( Pt 5)():1049-58.
1996: Shea J E; Hensel M; Gleeson C; Holden D W
Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2593-7.
1995: Hensel M; Shea J E; Gleeson C; Jones M D; Dalton E; Holden D W
Simultaneous identification of bacterial virulence genes by negative selection.
Science (New York, N.Y.) 1995;269(5222):400-3.
1995: Mellado E; Aufauvre-Brown A; Specht C A; Robbins P W; Holden D W
A multigene family related to chitin synthase genes of yeast in the opportunistic pathogen Aspergillus fumigatus.
Molecular & general genetics : MGG 1995;246(3):353-9.
1994: Tang C M; Smith J M; Arst H N; Holden D W
Virulence studies of Aspergillus nidulans mutants requiring lysine or p-aminobenzoic acid in invasive pulmonary aspergillosis.
Infection and immunity 1994;62(12):5255-60.
1994: Smith J M; Tang C M; Van Noorden S; Holden D W
Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis.
Infection and immunity 1994;62(12):5247-54.
1994: Tang C M; Cohen J; Rees A J; Holden D W
Molecular epidemiological study of invasive pulmonary aspergillosis in a renal transplantation unit.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1994;13(4):318-21.
1994: Holden D W; Tang C M; Smith J M
Molecular genetics of Aspergillus pathogenicity.
Antonie van Leeuwenhoek 1994;65(3):251-5.
1993: Tang C M; Holden D W; Aufauvre-Brown A; Cohen J
The detection of Aspergillus spp. by the polymerase chain reaction and its evaluation in bronchoalveolar lavage fluid.
The American review of respiratory disease 1993;148(5):1313-7.
1993: Smith J M; Davies J E; Holden D W
Construction and pathogenicity of Aspergillus fumigatus mutants that do not produce the ribotoxin restrictocin.
Molecular microbiology 1993;9(5):1071-7.
1993: Aufauvre-Brown A; Tang C M; Holden D W
Detection of gene-disruption events in Aspergillus transformants by polymerase chain reaction direct from conidiospores.
Current genetics 1993;24(1-2):177-8.
1993: Tang C M; Cohen J; Krausz T; Van Noorden S; Holden D W
The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis.
Infection and immunity 1993;61(5):1650-6.
1992: Aufauvre-Brown A; Cohen J; Holden D W
Use of randomly amplified polymorphic DNA markers to distinguish isolates of Aspergillus fumigatus.
Journal of clinical microbiology 1992;30(11):2991-3.
1992: Tang C M; Cohen J; Holden D W
An Aspergillus fumigatus alkaline protease mutant constructed by gene disruption is deficient in extracellular elastase activity.
Molecular microbiology 1992;6(12):1663-71.

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David Holden

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