FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Hazel Holden

Research Profile

Procedures

X Ray Crystallography

Concepts & Ideas

Chemicals & Drugs

Living Beings

Escherichia coli

Phenomena

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Mutagenesis, Site-Directed

Co-author Network

Publications

TOP 3
Rachel L Kubiak; E Malaika Maka; Rebecca K Phillips; Gwen L Pyeatt; Sarah J Roggensack; Matthew W Zmudka; Melissa R Ahn; Hazel M Holden
Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
Feng Song; James B Thoden; Michael Trujillo; Zhihao Zhuang; Hazel M Holden; John Latham; Debra Dunaway-Mariano
The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU.
Nathan A Bruender; Hazel M Holden
Probing the catalytic mechanism of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Hazel Holden (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Rachel L Kubiak; E Malaika Maka; Rebecca K Phillips; Gwen L Pyeatt; Sarah J Roggensack; Matthew W Zmudka; Melissa R Ahn; Hazel M Holden
Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
Biochemistry 2012;51(46):9375-83.
2012: Feng Song; James B Thoden; Michael Trujillo; Zhihao Zhuang; Hazel M Holden; John Latham; Debra Dunaway-Mariano
The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU.
Biochemistry 2012;51(35):7000-16.
2012: Nathan A Bruender; Hazel M Holden
Probing the catalytic mechanism of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose.
Protein science : a publication of the Protein Society 2012;21(6):876-86.
2012: James B Thoden; W Wallace Cleland; Paul D Cook; Patrick Menden; Laurie A Reinhardt; Hazel M Holden
Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses.
Biochemistry 2012;51(16):3433-44.
2012: Rachel L Kubiak; Hazel M Holden
Structural studies of AntD: an N-Acyltransferase involved in the biosynthesis of D-Anthrose.
Biochemistry 2012;51(4):867-78.
2011: Rachel L Kubiak; Hazel M Holden
Combined structural and functional investigation of a C-3''-ketoreductase involved in the biosynthesis of dTDP-L-digitoxose.
Biochemistry 2011;50(26):5905-17.
2011: James B Thoden; Hazel M Holden
Biochemical and structural characterization of WlbA from Bordetella pertussis and Chromobacterium violaceum: enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid.
Biochemistry 2011;50(9):1483-91.
2011: Amanda E Carney; Hazel M Holden
Molecular architecture of TylM1 from Streptomyces fradiae: an N,N-dimethyltransferase involved in the production of dTDP-D-mycaminose.
Biochemistry 2011;50(5):780-7.
2010: Hazel M Holden; Paul D Cook; James B Thoden
Biosynthetic enzymes of unusual microbial sugars.
Current opinion in structural biology 2010;20(5):543-50.
2010: James B Thoden; Hazel M Holden
Structural and functional studies of WlbA: A dehydrogenase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid .
Biochemistry 2010;49(36):7939-48.
2010: Nathan A Bruender; James B Thoden; Manpreet Kaur; Marie K Avey; Hazel M Holden
Molecular architecture of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose.
Biochemistry 2010;49(28):5891-8.
2010: James B Thoden; Hazel M Holden
Molecular structure of WlbB, a bacterial N-acetyltransferase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid .
Biochemistry 2010;49(22):4644-53.
2010: Nathan A Bruender; James B Thoden; Hazel M Holden
X-ray structure of kijd3, a key enzyme involved in the biosynthesis of D-kijanose.
Biochemistry 2010;49(17):3517-24.
2010: James B Thoden; Hazel M Holden; Hanumantharao Paritala; Steven M Firestine
Structural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase .
Biochemistry 2010;49(4):752-60.
2009: Paul D Cook; Rachel L Kubiak; Daniel P Toomey; Hazel M Holden
Two site-directed mutations are required for the conversion of a sugar dehydratase into an aminotransferase.
Biochemistry 2009;48(23):5246-53.
2009: Steven M Firestine; Hanumantharao Paritala; Jane E McDonnell; James B Thoden; Hazel M Holden
Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening.
Bioorganic & medicinal chemistry 2009;17(9):3317-23.
2009: James B Thoden; Paul D Cook; Christina Schäffer; Paul Messner; Hazel M Holden
Structural and functional studies of QdtC: an N-acetyltransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.
Biochemistry 2009;48(12):2699-709.
2009: James B Thoden; Christina Schäffer; Paul Messner; Hazel M Holden
Structural analysis of QdtB, an aminotransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.
Biochemistry 2009;48(7):1553-61.
2008: James B Thoden; Hazel M Holden; Steven M Firestine
Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.
Biochemistry 2008;47(50):13346-53.
2008: James B Thoden; Louise A Ryan; Richard J Reece; Hazel M Holden
The interaction between an acidic transcriptional activator and its inhibitor. The molecular basis of Gal4p recognition by Gal80p.
The Journal of biological chemistry 2008;283(44):30266-72.
2008: Paul D Cook; Amanda E Carney; Hazel M Holden
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
Biochemistry 2008;47(40):10685-93.
2008: E Sethe Burgie; Hazel M Holden
Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.
Biochemistry 2008;47(13):3982-8.
2008: Paul D Cook; Hazel M Holden
GDP-perosamine synthase: structural analysis and production of a novel trideoxysugar.
Biochemistry 2008;47(9):2833-40.
2008: Paul D Cook; Hazel M Holden
GDP-4-keto-6-deoxy-D-mannose 3-dehydratase, accommodating a sugar substrate in the active site.
The Journal of biological chemistry 2008;283(7):4295-303.
2007: Paul D Cook; Hazel M Holden
A structural study of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: caught in the act of geminal diamine formation.
Biochemistry 2007;46(49):14215-24.
2007: E Sethe Burgie; Hazel M Holden
Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.
Biochemistry 2007;46(31):8999-9006.
2007: James B Thoden; Hazel M Holden
Active site geometry of glucose-1-phosphate uridylyltransferase.
Protein science : a publication of the Protein Society 2007;16(7):1379-88.
2007: Melissa L Davis; James B Thoden; Hazel M Holden
The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase.
The Journal of biological chemistry 2007;282(26):19227-36.
2007: E Sethe Burgie; James B Thoden; Hazel M Holden
Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
Protein science : a publication of the Protein Society 2007;16(5):887-96.
2007: James B Thoden; Hazel M Holden
The molecular architecture of glucose-1-phosphate uridylyltransferase.
Protein science : a publication of the Protein Society 2007;16(3):432-40.
2007: James B Thoden; Christopher A Sellick; Richard J Reece; Hazel M Holden
Understanding a transcriptional paradigm at the molecular level. The structure of yeast Gal80p.
The Journal of biological chemistry 2007;282(3):1534-8.
2006: Paul D Cook; James B Thoden; Hazel M Holden
The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme.
Protein science : a publication of the Protein Society 2006;15(9):2093-106.
2005: Ricardo Martí-Arbona; James B Thoden; Hazel M Holden; Frank M Raushel
Functional significance of Glu-77 and Tyr-137 within the active site of isoaspartyl dipeptidase.
Bioorganic chemistry 2005;33(6):448-58.
2005: James B Thoden; Christopher A Sellick; David J Timson; Richard J Reece; Hazel M Holden
Molecular structure of Saccharomyces cerevisiae Gal1p, a bifunctional galactokinase and transcriptional inducer.
The Journal of biological chemistry 2005;280(44):36905-11.
2005: James B Thoden; Hazel M Holden
The molecular architecture of human N-acetylgalactosamine kinase.
The Journal of biological chemistry 2005;280(38):32784-91.
2005: James B Thoden; Hazel M Holden
The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae.
The Journal of biological chemistry 2005;280(23):21900-7.
2005: Ricardo Martí-Arbona; Vicente Fresquet; James B Thoden; Melissa L Davis; Hazel M Holden; Frank M Raushel
Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli.
Biochemistry 2005;44(19):7115-24.
2005: Nicole M Koropatkin; Hazel M Holden
Structure of CDP-D-glucose 4,6-dehydratase from Salmonella typhi complexed with CDP-D-xylose.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 4):365-73.
2005: Nicole M Koropatkin; W Wallace Cleland; Hazel M Holden
Kinetic and structural analysis of alpha-D-Glucose-1-phosphate cytidylyltransferase from Salmonella typhi.
The Journal of biological chemistry 2005;280(11):10774-80.
2005: James B Thoden; David J Timson; Richard J Reece; Hazel M Holden
Molecular structure of human galactokinase: implications for type II galactosemia.
The Journal of biological chemistry 2005;280(10):9662-70.
2005: Jamie Wasilenko; Mary Lucas; James B Thoden; Hazel M Holden; Judith L Fridovich-Keil
Functional characterization of the K257R and G319E-hGALE alleles found in patients with ostensibly peripheral epimerase deficiency galactosemia.
Molecular genetics and metabolism 2005;84(1):32-8.
2004: Nicole M Koropatkin; Hazel M Holden
Molecular structure of alpha-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhi.
The Journal of biological chemistry 2004;279(42):44023-9.
2004: Hazel M Holden; James B Thoden; David J Timson; Richard J Reece
Galactokinase: structure, function and role in type II galactosemia.
Cellular and molecular life sciences : CMLS 2004;61(19-20):2471-84.
2004: Paul G Blommel; David W Smith; Craig A Bingman; David H Dyer; Ivan Rayment; Hazel M Holden; Brian G Fox; George N Phillips
Crystal structure of gene locus At3g16990 from Arabidopsis thaliana.
Proteins 2004;57(1):221-2.
2004: James B Thoden; Xinyi Huang; Jungwook Kim; Frank M Raushel; Hazel M Holden
Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein science : a publication of the Protein Society 2004;13(9):2398-405.
2004: Jenny M Schulz; Alice L Watson; Rebecca Sanders; Kerry L Ross; James B Thoden; Hazel M Holden; Judith L Fridovich-Keil
Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase.
The Journal of biological chemistry 2004;279(31):32796-803.
2004: James B Thoden; David J Timson; Richard J Reece; Hazel M Holden
Molecular structure of human galactose mutarotase.
The Journal of biological chemistry 2004;279(22):23431-7.
2004: Vicente Fresquet; James B Thoden; Hazel M Holden; Frank M Raushel
Kinetic mechanism of asparagine synthetase from Vibrio cholerae.
Bioorganic chemistry 2004;32(2):63-75.
2004: Simon T M Allard; W Wallace Cleland; Hazel M Holden
High resolution X-ray structure of dTDP-glucose 4,6-dehydratase from Streptomyces venezuelae.
The Journal of biological chemistry 2004;279(3):2211-20.
2003: Hazel M Holden; Ivan Rayment; James B Thoden
Structure and function of enzymes of the Leloir pathway for galactose metabolism.
The Journal of biological chemistry 2003;278(45):43885-8.
2003: James B Thoden; Zhihao Zhuang; Debra Dunaway-Mariano; Hazel M Holden
The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU.
The Journal of biological chemistry 2003;278(44):43709-16.
2003: David H Dyer; Scott Lovell; James B Thoden; Hazel M Holden; Ivan Rayment; Que Lan
The structural determination of an insect sterol carrier protein-2 with a ligand-bound C16 fatty acid at 1.35-A resolution.
The Journal of biological chemistry 2003;278(40):39085-91.
2003: James B Thoden; Hazel M Holden
Molecular structure of galactokinase.
The Journal of biological chemistry 2003;278(35):33305-11.
2003: David H Dyer; Luis M Rubio; James B Thoden; Hazel M Holden; Paul W Ludden; Ivan Rayment
The three-dimensional structure of the core domain of Naf Y from Azotobacter vinelandii determined at 1.8-A resolution.
The Journal of biological chemistry 2003;278(34):32150-6.
2003: Craig M Hill; Wen-Shan Li; James B Thoden; Hazel M Holden; Frank M Raushel
Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.
Journal of the American Chemical Society 2003;125(30):8990-1.
2003: Frank M Raushel; James B Thoden; Hazel M Holden
Enzymes with molecular tunnels.
Accounts of chemical research 2003;36(7):539-48.
2003: Nicole M Koropatkin; Hung-Wen Liu; Hazel M Holden
High resolution x-ray structure of tyvelose epimerase from Salmonella typhi.
The Journal of biological chemistry 2003;278(23):20874-81.
2003: James B Thoden; Ricardo Marti-Arbona; Frank M Raushel; Hazel M Holden
High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli.
Biochemistry 2003;42(17):4874-82.
2003: James B Thoden; Jungwook Kim; Frank M Raushel; Hazel M Holden
The catalytic mechanism of galactose mutarotase.
Protein science : a publication of the Protein Society 2003;12(5):1051-9.
2002: James B Thoden; Jungwook Kim; Frank M Raushel; Hazel M Holden
Structural and kinetic studies of sugar binding to galactose mutarotase from Lactococcus lactis.
The Journal of biological chemistry 2002;277(47):45458-65.
2002: James B Thoden; Xinyi Huang; Frank M Raushel; Hazel M Holden
Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia.
The Journal of biological chemistry 2002;277(42):39722-7.
2002: James B Thoden; Jenny M Henderson; Judith L Fridovich-Keil; Hazel M Holden
Structural analysis of the Y299C mutant of Escherichia coli UDP-galactose 4-epimerase. Teaching an old dog new tricks.
The Journal of biological chemistry 2002;277(30):27528-34.
2002: James B Thoden; Hazel M Holden; Zhihao Zhuang; Debra Dunaway-Mariano
X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase.
The Journal of biological chemistry 2002;277(30):27468-76.
2002: James B Thoden; Steven M Firestine; Stephen J Benkovic; Hazel M Holden
PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site.
The Journal of biological chemistry 2002;277(26):23898-908.
2002: James B Thoden; Hazel M Holden
High resolution X-ray structure of galactose mutarotase from Lactococcus lactis.
The Journal of biological chemistry 2002;277(23):20854-61.
2001: Wenhai Zhang; Yansheng Wei; Lusong Luo; Kimberly Taylor; G Yang; Debra Dunaway-Mariano; Matthew M Benning; Hazel M Holden
Histidine 90 function in 4-chlorobenzoyl-coenzyme a dehalogenase catalysis.
Biochemistry 2001;40(45):13474-82.
2001: James B Thoden; George N Phillips; T M Neal; Frank M Raushel; Hazel M Holden
Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.
Biochemistry 2001;40(24):6989-97.
2001: James B Thoden; TM Wohlers; Judith L Fridovich-Keil; Hazel M Holden
Molecular basis for severe epimerase deficiency galactosemia. X-ray structure of the human V94m-substituted UDP-galactose 4-epimerase.
The Journal of biological chemistry 2001;276(23):20617-23.
2001: James B Thoden; TM Wohlers; Judith L Fridovich-Keil; Hazel M Holden
Human UDP-galactose 4-epimerase. Accommodation of UDP-N-acetylglucosamine within the active site.
The Journal of biological chemistry 2001;276(18):15131-6.
2001: Matthew M Benning; H Shim; Frank M Raushel; Hazel M Holden
High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.
Biochemistry 2001;40(9):2712-22.
2001: Hazel M Holden; Matthew M Benning; T Haller; John Alan Gerlt
The crotonase superfamily: divergently related enzymes that catalyze different reactions involving acyl coenzyme a thioesters.
Accounts of chemical research 2001;34(2):145-57.
2001: Cay Brian Bauer; Maris V Fonseca; Hazel M Holden; James B Thoden; Thomas B Thompson; Jorge C Escalante-Semerena; Ivan Rayment
Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP.
Biochemistry 2001;40(2):361-74.
2000: Cay Brian Bauer; Hazel M Holden; James B Thoden; R Smith; Ivan Rayment
X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain.
The Journal of biological chemistry 2000;275(49):38494-9.
2000: Matthew M Benning; S B Hong; Frank M Raushel; Hazel M Holden
The binding of substrate analogs to phosphotriesterase.
The Journal of biological chemistry 2000;275(39):30556-60.
2000: James B Thoden; Steven M Firestine; A Nixon; Stephen J Benkovic; Hazel M Holden
Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.
Biochemistry 2000;39(30):8791-802.
2000: James B Thoden; CZ Blanchard; Hazel M Holden; Grover L Waldrop
Movement of the biotin carboxylase B-domain as a result of ATP binding.
The Journal of biological chemistry 2000;275(21):16183-90.
2000: James B Thoden; TM Wohlers; Judith L Fridovich-Keil; Hazel M Holden
Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase.
Biochemistry 2000;39(19):5691-701.
2000: Matthew M Benning; T Haller; John Alan Gerlt; Hazel M Holden
New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli.
Biochemistry 2000;39(16):4630-9.
2000: Frank M Raushel; Hazel M Holden
Phosphotriesterase: an enzyme in search of its natural substrate.
Advances in enzymology and related areas of molecular biology 2000;74():51-93.
1999: James B Thoden; Xinyi Huang; Frank M Raushel; Hazel M Holden
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry 1999;38(49):16158-66.
1999: Todd M Larsen; Susan K Boehlein; Sheldon M Schuster; Nigel G J Richards; James B Thoden; Hazel M Holden; Ivan Rayment
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.
Biochemistry 1999;38(49):16146-57.
1999: James B Thoden; T J Kappock; J Stubbe; Hazel M Holden
Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily.
Biochemistry 1999;38(47):15480-92.
1999: Hazel M Holden; James B Thoden; Frank M Raushel
Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product.
Cellular and molecular life sciences : CMLS 1999;56(5-6):507-22.
1999: James B Thoden; Frank M Raushel; Gary E Wesenberg; Hazel M Holden
The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase.
The Journal of biological chemistry 1999;274(32):22502-7.
1999: Frank M Raushel; James B Thoden; Hazel M Holden
The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.
Biochemistry 1999;38(25):7891-9.
1999: James B Thoden; Gary E Wesenberg; Frank M Raushel; Hazel M Holden
Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
Biochemistry 1999;38(8):2347-57.
1999: Janeen L Vanhooke; James B Thoden; N M Brunhuber; John S Blanchard; Hazel M Holden
Phenylalanine dehydrogenase from Rhodococcus sp. M4: high-resolution X-ray analyses of inhibitory ternary complexes reveal key features in the oxidative deamination mechanism.
Biochemistry 1999;38(8):2326-39.
1999: James B Thoden; Frank M Raushel; Matthew M Benning; Ivan Rayment; Hazel M Holden
The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):8-24.
1998: Matthew M Benning; Gary E Wesenberg; R Liu; K L Taylor; Debra Dunaway-Mariano; Hazel M Holden
The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3.
The Journal of biological chemistry 1998;273(50):33572-9.
1998: Hazel M Holden; James B Thoden; Frank M Raushel
Carbamoyl phosphate synthetase: a tunnel runs through it.
Current opinion in structural biology 1998;8(6):679-85.
1998: Frank M Raushel; James B Thoden; Gregory D Reinhart; Hazel M Holden
Carbamoyl phosphate synthetase: a crooked path from substrates to products.
Current opinion in chemical biology 1998;2(5):624-32.
1998: James B Thoden; Hazel M Holden
Dramatic differences in the binding of UDP-galactose and UDP-glucose to UDP-galactose 4-epimerase from Escherichia coli.
Biochemistry 1998;37(33):11469-77.
1998: James B Thoden; S G Miran; J C Phillips; A J Howard; Frank M Raushel; Hazel M Holden
Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis.
Biochemistry 1998;37(25):8825-31.
1997: John K Hurley; AM Weber-Main; A E Hodges; Marian T Stankovich; Matthew M Benning; Hazel M Holden; H Cheng; B Xia; John Lute Markley; C Genzor; C Gomez-Moreno; R Hafezi; Gordon Tollin
Iron-sulfur cluster cysteine-to-serine mutants of Anabaena -2Fe-2S- ferredoxin exhibit unexpected redox properties and are competent in electron transfer to ferredoxin:NADP+ reductase.
Biochemistry 1997;36(49):15109-17.
1997: John K Hurley; AM Weber-Main; Marian T Stankovich; Matthew M Benning; James B Thoden; Janeen L Vanhooke; Hazel M Holden; Y K Chae; B Xia; H Cheng; John Lute Markley; M Martinez-Júlvez; Carlos Gómez-Moreno; James Schmeits; Gordon Tollin
Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants.
Biochemistry 1997;36(37):11100-17.
1997: James B Thoden; Andrew Gulick; Hazel M Holden
Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli.
Biochemistry 1997;36(35):10685-95.
1997: Y Liu; James B Thoden; J Kim; E Berger; Andrew Gulick; Frank J Ruzicka; Hazel M Holden; Perry A Frey
Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli.
Biochemistry 1997;36(35):10675-84.
1997: James B Thoden; Hazel M Holden; Gary E Wesenberg; Frank M Raushel; Ivan Rayment
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product.
Biochemistry 1997;36(21):6305-16.
1997: James B Thoden; Adrian D Hegeman; Gary E Wesenberg; M C Chapeau; Perry A Frey; Hazel M Holden
Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli.
Biochemistry 1997;36(21):6294-304.
1997: James B Thoden; Frank J Ruzicka; Perry A Frey; Ivan Rayment; Hazel M Holden
Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site.
Biochemistry 1997;36(6):1212-22.
1997: James B Thoden; Hazel M Holden; A J Fisher; J F Sinclair; Gary E Wesenberg; Thomas O Baldwin; Ivan Rayment
Structure of the beta 2 homodimer of bacterial luciferase from Vibrio harveyi: X-ray analysis of a kinetic protein folding trap.
Protein science : a publication of the Protein Society 1997;6(1):13-23.
1996: Hazel M Holden; Gary E Wesenberg; D A Raynes; D J Hartshorne; Vince Guerriero; Ivan Rayment
Molecular structure of a proteolytic fragment of TLP20.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 6):1153-60.
1996: James B Thoden; Perry A Frey; Hazel M Holden
High-resolution X-ray structure of UDP-galactose 4-epimerase complexed with UDP-phenol.
Protein science : a publication of the Protein Society 1996;5(11):2149-61.
1996: Matthew M Benning; T E Meyer; Hazel M Holden
Molecular structure of a high potential cytochrome c2 isolated from Rhodopila globiformis.
Archives of biochemistry and biophysics 1996;333(2):338-48.
1996: Matthew M Benning; K L Taylor; G Yang; H Xiang; Gary E Wesenberg; Debra Dunaway-Mariano; Hazel M Holden
Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation.
Biochemistry 1996;35(25):8103-9.
1996: Janeen L Vanhooke; Matthew M Benning; Frank M Raushel; Hazel M Holden
Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate.
Biochemistry 1996;35(19):6020-5.
1996: James B Thoden; Perry A Frey; Hazel M Holden
Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism.
Biochemistry 1996;35(16):5137-44.
1996: James B Thoden; Perry A Frey; Hazel M Holden
Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli.
Biochemistry 1996;35(8):2557-66.
1995: L C Pedersen; Matthew M Benning; Hazel M Holden
Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase.
Biochemistry 1995;34(41):13305-11.
1995: A J Fisher; Clyde Smith; James B Thoden; R Smith; K Sutoh; Hazel M Holden; Ivan Rayment
X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-.
Biochemistry 1995;34(28):8960-72.
1995: Matthew M Benning; J M Kuo; Frank M Raushel; Hazel M Holden
Three-dimensional structure of the binuclear metal center of phosphotriesterase.
Biochemistry 1995;34(25):7973-8.
1995: A J Fisher; Clyde Smith; James B Thoden; R Smith; K Sutoh; Hazel M Holden; Ivan Rayment
Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction.
Biophysical journal 1995;68(4 Suppl):19S-26S; discussion 27S-28S.
1995: John K Hurley; Michael Caffrey; John Lute Markley; H Cheng; B Xia; Young Kee Chae; Hazel M Holden; Gordon Tollin
Mutations of surface residues in Anabaena vegetative and heterocyst ferredoxin that affect thermodynamic stability as determined by guanidine hydrochloride denaturation.
Protein science : a publication of the Protein Society 1995;4(1):58-64.
1994: Matthew M Benning; J M Kuo; Frank M Raushel; Hazel M Holden
Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents.
Biochemistry 1994;33(50):15001-7.
1994: Norbert H Haunerland; B L Jacobson; Gary E Wesenberg; Ivan Rayment; Hazel M Holden
Three-dimensional structure of the muscle fatty-acid-binding protein isolated from the desert locust Schistocerca gregaria.
Biochemistry 1994;33(41):12378-85.
1994: G L Waldrop; Ivan Rayment; Hazel M Holden
Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase.
Biochemistry 1994;33(34):10249-56.
1994: Todd M Larsen; L T Laughlin; Hazel M Holden; Ivan Rayment; George H Reed
Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate.
Biochemistry 1994;33(20):6301-9.
1994: Matthew M Benning; T E Meyer; Hazel M Holden
X-Ray structure of the cytochrome c2 isolated from Paracoccus denitrificans refined to 1.7-A resolution.
Archives of biochemistry and biophysics 1994;310(2):460-6.
1994: Matthew M Benning; T E Meyer; Ivan Rayment; Hazel M Holden
Molecular structure of the oxidized high-potential iron-sulfur protein isolated from Ectothiorhodospira vacuolata.
Biochemistry 1994;33(9):2476-83.
1994: Hazel M Holden; B L Jacobson; John K Hurley; Gordon Tollin; B H Oh; L Skjeldal; Young Kee Chae; H Cheng; B Xia; John Lute Markley
Structure-function studies of [2Fe-2S] ferredoxins.
Journal of bioenergetics and biomembranes 1994;26(1):67-88.
1994: G Waldrop; Hazel M Holden; Ivan Rayment
Preliminary X-ray crystallographic analysis of biotin carboxylase isolated from Escherichia coli.
Journal of molecular biology 1994;235(1):367-9.
1993: J Sakon; H H Liao; A M Kanikula; Matthew M Benning; Ivan Rayment; Hazel M Holden
Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-A resolution.
Biochemistry 1993;32(45):11977-84.
1993: W R Rypniewski; Hazel M Holden; Ivan Rayment
Structural consequences of reductive methylation of lysine residues in hen egg white lysozyme: an X-ray analysis at 1.8-A resolution.
Biochemistry 1993;32(37):9851-8.
1993: B L Jacobson; Young Kee Chae; John Lute Markley; Ivan Rayment; Hazel M Holden
Molecular structure of the oxidized, recombinant, heterocyst [2Fe-2S] ferredoxin from Anabaena 7120 determined to 1.7-A resolution.
Biochemistry 1993;32(26):6788-93.
1993: Ivan Rayment; Hazel M Holden; M Whittaker; C B Yohn; Michael Lorenz; Kenneth C Holmes; R A Milligan
Structure of the actin-myosin complex and its implications for muscle contraction.
Science (New York, N.Y.) 1993;261(5117):58-65.
1993: Ivan Rayment; W R Rypniewski; K Schmidt-Bäse; R Smith; D R Tomchick; Matthew M Benning; Donald A Winkelmann; Gary E Wesenberg; Hazel M Holden
Three-dimensional structure of myosin subfragment-1: a molecular motor.
Science (New York, N.Y.) 1993;261(5117):50-8.
1992: Ivan Rayment; Gary E Wesenberg; T E Meyer; M A Cusanovich; Hazel M Holden
Three-dimensional structure of the high-potential iron-sulfur protein isolated from the purple phototrophic bacterium Rhodocyclus tenuis determined and refined at 1.5 A resolution.
Journal of molecular biology 1992;228(2):672-86.
1992: Matthew M Benning; A F Smith; M A Wells; Hazel M Holden
Crystallization, structure determination and least-squares refinement to 1.75 A resolution of the fatty-acid-binding protein isolated from Manduca sexta L.
Journal of molecular biology 1992;228(1):208-19.
1992: Hazel M Holden; M Ito; D J Hartshorne; Ivan Rayment
X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.
Journal of molecular biology 1992;227(3):840-51.
1992: A M Kanikula; H H Liao; J Sakon; Hazel M Holden; Ivan Rayment
Crystallization and preliminary crystallographic analysis of a thermostable mutant of kanamycin nucleotidyltransferase.
Archives of biochemistry and biophysics 1992;295(1):1-4.
1992: A J Bauer; Ivan Rayment; Perry A Frey; Hazel M Holden
The molecular structure of UDP-galactose 4-epimerase from Escherichia coli determined at 2.5 A resolution.
Proteins 1992;12(4):372-81.
1992: B L Jacobson; Young Kee Chae; H Böhme; John Lute Markley; Hazel M Holden
Crystallization and preliminary analysis of oxidized, recombinant, heterocyst [2Fe-2S] ferredoxin from Anabaena 7120.
Archives of biochemistry and biophysics 1992;294(1):279-81.
1992: Perry A Frey; A J Bauer; Janeen L Vanhooke; J M Konopka; Ivan Rayment; Hazel M Holden
Chemical spectroscopic and crystallographic studies of UDP-galactose 4-epimerase from Escherichia coli.
Journal of nutritional science and vitaminology 1992;Spec No():461-4.
1991: Hazel M Holden; Ivan Rayment
Trimethyllead acetate: a first-choice heavy atom derivative for protein crystallography.
Archives of biochemistry and biophysics 1991;291(1):187-94.
1991: Deborah Breiter; T E Meyer; Ivan Rayment; Hazel M Holden
The molecular structure of the high potential iron-sulfur protein isolated from Ectothiorhodospira halophila determined at 2.5-A resolution.
The Journal of biological chemistry 1991;266(28):18660-7.
1991: Matthew M Benning; Gary E Wesenberg; Michael Caffrey; R G Bartsch; T E Meyer; M A Cusanovich; Ivan Rayment; Hazel M Holden
Molecular structure of cytochrome c2 isolated from Rhodobacter capsulatus determined at 2.5 A resolution.
Journal of molecular biology 1991;220(3):673-85.
1991: L Skjeldal; William M Westler; B H Oh; A M Krezel; Hazel M Holden; B L Jacobson; Ivan Rayment; John Lute Markley
Two-dimensional magnetization exchange spectroscopy of Anabaena 7120 ferredoxin. Nuclear Overhauser effect and electron self-exchange cross peaks from amino acid residues surrounding the 2Fe-2S* cluster.
Biochemistry 1991;30(30):7363-8.
1991: W R Rypniewski; Deborah Breiter; Matthew M Benning; Gary E Wesenberg; B H Oh; John Lute Markley; Ivan Rayment; Hazel M Holden
Crystallization and structure determination to 2.5-A resolution of the oxidized [2Fe-2S] ferredoxin isolated from Anabaena 7120.
Biochemistry 1991;30(17):4126-31.
1991: Michael Caffrey; F Daldal; Hazel M Holden; Michael A Cusanovich
Importance of a conserved hydrogen-bonding network in cytochromes c to their redox potentials and stabilities.
Biochemistry 1991;30(17):4119-25.
1991: Deborah Breiter; Michael R Kanost; Matthew M Benning; Gary E Wesenberg; John H Law; M A Wells; Ivan Rayment; Hazel M Holden
Molecular structure of an apolipoprotein determined at 2.5-A resolution.
Biochemistry 1991;30(3):603-8.
1991: A J Bauer; Ivan Rayment; Perry A Frey; Hazel M Holden
The isolation, purification, and preliminary crystallographic characterization of UDP-galactose-4-epimerase from Escherichia coli.
Proteins 1991;9(2):135-42.
1988: Hazel M Holden; Michael R Kanost; John H Law; Ivan Rayment; Michael A Wells
Crystallization and preliminary analysis of crystals of apolipophorin III isolated from Locusta migratoria.
The Journal of biological chemistry 1988;263(8):3960-2.
1987: Hazel M Holden; W R Rypniewski; J H Law; Ivan Rayment
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.
The EMBO journal 1987;6(6):1565-70.
1987: Hazel M Holden; Terry E Meyer; Michael A Cusanovich; F Daldal; Ivan Rayment
Crystallization and preliminary analysis of crystals of cytochrome c2 from Rhodopseudomonas capsulata.
Journal of molecular biology 1987;195(1):229-31.