Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Hazel Holden

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Procedures

X-Ray Crystallography

Concepts & Ideas

Chemicals & Drugs

Living Beings

Escherichia coli

Genes & Molecular Sequences

Phenomena

Physiology

Site-Directed Mutagenesis

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
71
Thoden, James
39
Rayment, Ivan
27
Raushel, Frank
23
Benning, Matthew
14
Wesenberg, Gary
9
Frey, Perry
6
Fridovich-Keil, Judith
6
Reece, Richard
5
Dunaway-Mariano, Debra
4
Chae, Young Kee
4
Hurley, John
4
Koropatkin, Nicole
4
Xia, B
4
Timson, David
4
Tollin, Gordon

Sign-in to see all Coauthors

Publications

TOP 3
Cook Paul D; Kubiak Rachel L; Toomey Daniel P; Holden Hazel M
Two site-directed mutations are required for the conversion of a sugar dehydratase into an aminotransferase.
Firestine Steven M; Paritala Hanumantharao; McDonnell Jane E; Thoden James B; Holden Hazel M
Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening.
Thoden James B; Cook Paul D; Schäffer Christina; Messner Paul; Holden Hazel M
Structural and functional studies of QdtC: an N-acetyltransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Hazel Holden (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Cook Paul D; Kubiak Rachel L; Toomey Daniel P; Holden Hazel M
Two site-directed mutations are required for the conversion of a sugar dehydratase into an aminotransferase.
Biochemistry 2009;48(23):5246-53.
2009: Firestine Steven M; Paritala Hanumantharao; McDonnell Jane E; Thoden James B; Holden Hazel M
Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening.
Bioorganic & medicinal chemistry 2009;17(9):3317-23.
2009: Thoden James B; Cook Paul D; Schäffer Christina; Messner Paul; Holden Hazel M
Structural and functional studies of QdtC: an N-acetyltransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.
Biochemistry 2009;48(12):2699-709.
2009: Thoden James B; Schäffer Christina; Messner Paul; Holden Hazel M
Structural analysis of QdtB, an aminotransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.
Biochemistry 2009;48(7):1553-61.
2008: Thoden James B; Holden Hazel M; Firestine Steven M
Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli.
Biochemistry 2008;47(50):13346-53.
2008: Cook Paul D; Carney Amanda E; Holden Hazel M
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase.
Biochemistry 2008;47(40):10685-93.
2008: Thoden James B; Ryan Louise A; Reece Richard J; Holden Hazel M
The interaction between an acidic transcriptional activator and its inhibitor. The molecular basis of Gal4p recognition by Gal80p.
The Journal of biological chemistry 2008;283(44):30266-72.
2008: Burgie E Sethe; Holden Hazel M
Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis.
Biochemistry 2008;47(13):3982-8.
2008: Cook Paul D; Holden Hazel M
GDP-perosamine synthase: structural analysis and production of a novel trideoxysugar.
Biochemistry 2008;47(9):2833-40.
2008: Cook Paul D; Holden Hazel M
GDP-4-keto-6-deoxy-D-mannose 3-dehydratase, accommodating a sugar substrate in the active site.
The Journal of biological chemistry 2008;283(7):4295-303.
2007: Cook Paul D; Holden Hazel M
A structural study of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: caught in the act of geminal diamine formation.
Biochemistry 2007;46(49):14215-24.
2007: Burgie E Sethe; Holden Hazel M
Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine.
Biochemistry 2007;46(31):8999-9006.
2007: Thoden James B; Holden Hazel M
Active site geometry of glucose-1-phosphate uridylyltransferase.
Protein science : a publication of the Protein Society 2007;16(7):1379-88.
2007: Davis Melissa L; Thoden James B; Holden Hazel M
The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase.
The Journal of biological chemistry 2007;282(26):19227-36.
2007: Burgie E Sethe; Thoden James B; Holden Hazel M
Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine.
Protein science : a publication of the Protein Society 2007;16(5):887-96.
2007: Thoden James B; Holden Hazel M
The molecular architecture of glucose-1-phosphate uridylyltransferase.
Protein science : a publication of the Protein Society 2007;16(3):432-40.
2007: Thoden James B; Sellick Christopher A; Reece Richard J; Holden Hazel M
Understanding a transcriptional paradigm at the molecular level. The structure of yeast Gal80p.
The Journal of biological chemistry 2007;282(3):1534-8.
2006: Cook Paul D; Thoden James B; Holden Hazel M
The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme.
Protein science : a publication of the Protein Society 2006;15(9):2093-106.
2005: Martí-Arbona Ricardo; Thoden James B; Holden Hazel M; Raushel Frank M
Functional significance of Glu-77 and Tyr-137 within the active site of isoaspartyl dipeptidase.
Bioorganic chemistry 2005;33(6):448-58.
2005: Thoden James B; Sellick Christopher A; Timson David J; Reece Richard J; Holden Hazel M
Molecular structure of Saccharomyces cerevisiae Gal1p, a bifunctional galactokinase and transcriptional inducer.
The Journal of biological chemistry 2005;280(44):36905-11.
2005: Thoden James B; Holden Hazel M
The molecular architecture of human N-acetylgalactosamine kinase.
The Journal of biological chemistry 2005;280(38):32784-91.
2005: Thoden James B; Holden Hazel M
The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae.
The Journal of biological chemistry 2005;280(23):21900-7.
2005: Martí-Arbona Ricardo; Fresquet Vicente; Thoden James B; Davis Melissa L; Holden Hazel M; Raushel Frank M
Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli.
Biochemistry 2005;44(19):7115-24.
2005: Koropatkin Nicole M; Holden Hazel M
Structure of CDP-D-glucose 4,6-dehydratase from Salmonella typhi complexed with CDP-D-xylose.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 4):365-73.
2005: Koropatkin Nicole M; Cleland W Wallace; Holden Hazel M
Kinetic and structural analysis of alpha-D-Glucose-1-phosphate cytidylyltransferase from Salmonella typhi.
The Journal of biological chemistry 2005;280(11):10774-80.
2005: Thoden James B; Timson David J; Reece Richard J; Holden Hazel M
Molecular structure of human galactokinase: implications for type II galactosemia.
The Journal of biological chemistry 2005;280(10):9662-70.
2005: Wasilenko Jamie; Lucas Mary E; Thoden James B; Holden Hazel M; Fridovich-Keil Judith L
Functional characterization of the K257R and G319E-hGALE alleles found in patients with ostensibly peripheral epimerase deficiency galactosemia.
Molecular genetics and metabolism 2005;84(1):32-8.
2004: Holden H M; Thoden J B; Timson D J; Reece R J
Galactokinase: structure, function and role in type II galactosemia.
Cellular and molecular life sciences : CMLS 2004;61(19-20):2471-84.
2004: Blommel Paul G; Smith David W; Bingman Craig A; Dyer David H; Rayment Ivan; Holden Hazel M; Fox Brian G; Phillips George N
Crystal structure of gene locus At3g16990 from Arabidopsis thaliana.
Proteins 2004;57(1):221-2.
2004: Koropatkin Nicole M; Holden Hazel M
Molecular structure of alpha-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhi.
The Journal of biological chemistry 2004;279(42):44023-9.
2004: Thoden James B; Huang Xinyi; Kim Jungwook; Raushel Frank M; Holden Hazel M
Long-range allosteric transitions in carbamoyl phosphate synthetase.
Protein science : a publication of the Protein Society 2004;13(9):2398-405.
2004: Schulz Jenny M; Watson Alice L; Sanders Rebecca; Ross Kerry L; Thoden James B; Holden Hazel M; Fridovich-Keil Judith L
Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase.
The Journal of biological chemistry 2004;279(31):32796-803.
2004: Thoden James B; Timson David J; Reece Richard J; Holden Hazel M
Molecular structure of human galactose mutarotase.
The Journal of biological chemistry 2004;279(22):23431-7.
2004: Fresquet Vicente; Thoden James B; Holden Hazel M; Raushel Frank M
Kinetic mechanism of asparagine synthetase from Vibrio cholerae.
Bioorganic chemistry 2004;32(2):63-75.
2004: Allard Simon T M; Cleland W W; Holden Hazel M
High resolution X-ray structure of dTDP-glucose 4,6-dehydratase from Streptomyces venezuelae.
The Journal of biological chemistry 2004;279(3):2211-20.
2003: Holden Hazel M; Rayment Ivan; Thoden James B
Structure and function of enzymes of the Leloir pathway for galactose metabolism.
The Journal of biological chemistry 2003;278(45):43885-8.
2003: Thoden James B; Zhuang Zhihao; Dunaway-Mariano Debra; Holden Hazel M
The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU.
The Journal of biological chemistry 2003;278(44):43709-16.
2003: Dyer David H; Lovell Scott; Thoden James B; Holden Hazel M; Rayment Ivan; Lan Que
The structural determination of an insect sterol carrier protein-2 with a ligand-bound C16 fatty acid at 1.35-A resolution.
The Journal of biological chemistry 2003;278(40):39085-91.
2003: Thoden James B; Holden Hazel M
Molecular structure of galactokinase.
The Journal of biological chemistry 2003;278(35):33305-11.
2003: Dyer David H; Rubio Luis M; Thoden James B; Holden Hazel M; Ludden Paul W; Rayment Ivan
The three-dimensional structure of the core domain of Naf Y from Azotobacter vinelandii determined at 1.8-A resolution.
The Journal of biological chemistry 2003;278(34):32150-6.
2003: Hill Craig M; Li Wen-Shan; Thoden James B; Holden Hazel M; Raushel Frank M
Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.
Journal of the American Chemical Society 2003;125(30):8990-1.
2003: Raushel Frank M; Thoden James B; Holden Hazel M
Enzymes with molecular tunnels.
Accounts of chemical research 2003;36(7):539-48.
2003: Koropatkin Nicole M; Liu Hung-Wen; Holden Hazel M
High resolution x-ray structure of tyvelose epimerase from Salmonella typhi.
The Journal of biological chemistry 2003;278(23):20874-81.
2003: Thoden James B; Marti-Arbona Ricardo; Raushel Frank M; Holden Hazel M
High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli.
Biochemistry 2003;42(17):4874-82.
2003: Thoden James B; Kim Jungwook; Raushel Frank M; Holden Hazel M
The catalytic mechanism of galactose mutarotase.
Protein science : a publication of the Protein Society 2003;12(5):1051-9.
2002: Thoden James B; Kim Jungwook; Raushel Frank M; Holden Hazel M
Structural and kinetic studies of sugar binding to galactose mutarotase from Lactococcus lactis.
The Journal of biological chemistry 2002;277(47):45458-65.
2002: Thoden James B; Huang Xinyi; Raushel Frank M; Holden Hazel M
Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia.
The Journal of biological chemistry 2002;277(42):39722-7.
2002: Thoden James B; Henderson Jenny M; Fridovich-Keil Judith L; Holden Hazel M
Structural analysis of the Y299C mutant of Escherichia coli UDP-galactose 4-epimerase. Teaching an old dog new tricks.
The Journal of biological chemistry 2002;277(30):27528-34.
2002: Thoden James B; Holden Hazel M; Zhuang Zhihao; Dunaway-Mariano Debra
X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase.
The Journal of biological chemistry 2002;277(30):27468-76.
2002: Thoden James B; Firestine Steven M; Benkovic Stephen J; Holden Hazel M
PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site.
The Journal of biological chemistry 2002;277(26):23898-908.
2002: Thoden James B; Holden Hazel M
High resolution X-ray structure of galactose mutarotase from Lactococcus lactis.
The Journal of biological chemistry 2002;277(23):20854-61.
2001: Zhang W; Wei Y; Luo L; Taylor K L; Yang G; Dunaway-Mariano D; Benning M M; Holden H M
Histidine 90 function in 4-chlorobenzoyl-coenzyme a dehalogenase catalysis.
Biochemistry 2001;40(45):13474-82.
2001: Thoden J B; Phillips G N; Neal T M; Raushel F M; Holden H M
Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center.
Biochemistry 2001;40(24):6989-97.
2001: Thoden J B; Wohlers T M; Fridovich-Keil J L; Holden H M
Molecular basis for severe epimerase deficiency galactosemia. X-ray structure of the human V94m-substituted UDP-galactose 4-epimerase.
The Journal of biological chemistry 2001;276(23):20617-23.
2001: Thoden J B; Wohlers T M; Fridovich-Keil J L; Holden H M
Human UDP-galactose 4-epimerase. Accommodation of UDP-N-acetylglucosamine within the active site.
The Journal of biological chemistry 2001;276(18):15131-6.
2001: Benning M M; Shim H; Raushel F M; Holden H M
High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.
Biochemistry 2001;40(9):2712-22.
2001: Holden H M; Benning M M; Haller T; Gerlt J A
The crotonase superfamily: divergently related enzymes that catalyze different reactions involving acyl coenzyme a thioesters.
Accounts of chemical research 2001;34(2):145-57.
2001: Bauer C B; Fonseca M V; Holden H M; Thoden J B; Thompson T B; Escalante-Semerena J C; Rayment I
Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP.
Biochemistry 2001;40(2):361-74.
2000: Bauer C B; Holden H M; Thoden J B; Smith R; Rayment I
X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain.
The Journal of biological chemistry 2000;275(49):38494-9.
2000: Benning M M; Hong S B; Raushel F M; Holden H M
The binding of substrate analogs to phosphotriesterase.
The Journal of biological chemistry 2000;275(39):30556-60.
2000: Thoden J B; Firestine S; Nixon A; Benkovic S J; Holden H M
Molecular structure of Escherichia coli PurT-encoded glycinamide ribonucleotide transformylase.
Biochemistry 2000;39(30):8791-802.
2000: Thoden J B; Blanchard C Z; Holden H M; Waldrop G L
Movement of the biotin carboxylase B-domain as a result of ATP binding.
The Journal of biological chemistry 2000;275(21):16183-90.
2000: Thoden J B; Wohlers T M; Fridovich-Keil J L; Holden H M
Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase.
Biochemistry 2000;39(19):5691-701.
2000: Benning M M; Haller T; Gerlt J A; Holden H M
New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli.
Biochemistry 2000;39(16):4630-9.
2000: Raushel F M; Holden H M
Phosphotriesterase: an enzyme in search of its natural substrate.
Advances in enzymology and related areas of molecular biology 2000;74():51-93.
1999: Thoden J B; Huang X; Raushel F M; Holden H M
The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.
Biochemistry 1999;38(49):16158-66.
1999: Larsen T M; Boehlein S K; Schuster S M; Richards N G; Thoden J B; Holden H M; Rayment I
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product.
Biochemistry 1999;38(49):16146-57.
1999: Thoden J B; Kappock T J; Stubbe J; Holden H M
Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily.
Biochemistry 1999;38(47):15480-92.
1999: Holden H M; Thoden J B; Raushel F M
Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product.
Cellular and molecular life sciences : CMLS 1999;56(5-6):507-22.
1999: Thoden J B; Raushel F M; Wesenberg G; Holden H M
The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase.
The Journal of biological chemistry 1999;274(32):22502-7.
1999: Raushel F M; Thoden J B; Holden H M
The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.
Biochemistry 1999;38(25):7891-9.
1999: Thoden J B; Wesenberg G; Raushel F M; Holden H M
Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding.
Biochemistry 1999;38(8):2347-57.
1999: Vanhooke J L; Thoden J B; Brunhuber N M; Blanchard J S; Holden H M
Phenylalanine dehydrogenase from Rhodococcus sp. M4: high-resolution X-ray analyses of inhibitory ternary complexes reveal key features in the oxidative deamination mechanism.
Biochemistry 1999;38(8):2326-39.
1999: Thoden J B; Raushel F M; Benning M M; Rayment I; Holden H M
The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 1):8-24.
1998: Holden H M; Thoden J B; Raushel F M
Carbamoyl phosphate synthetase: a tunnel runs through it.
Current opinion in structural biology 1998;8(6):679-85.
1998: Benning M M; Wesenberg G; Liu R; Taylor K L; Dunaway-Mariano D; Holden H M
The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3.
The Journal of biological chemistry 1998;273(50):33572-9.
1998: Raushel F M; Thoden J B; Reinhart G D; Holden H M
Carbamoyl phosphate synthetase: a crooked path from substrates to products.
Current opinion in chemical biology 1998;2(5):624-32.
1998: Thoden J B; Holden H M
Dramatic differences in the binding of UDP-galactose and UDP-glucose to UDP-galactose 4-epimerase from Escherichia coli.
Biochemistry 1998;37(33):11469-77.
1998: Thoden J B; Miran S G; Phillips J C; Howard A J; Raushel F M; Holden H M
Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis.
Biochemistry 1998;37(25):8825-31.
1997: Hurley J K; Weber-Main A M; Hodges A E; Stankovich M T; Benning M M; Holden H M; Cheng H; Xia B; Markley J L; Genzor C; Gomez-Moreno C; Hafezi R; Tollin G
Iron-sulfur cluster cysteine-to-serine mutants of Anabaena -2Fe-2S- ferredoxin exhibit unexpected redox properties and are competent in electron transfer to ferredoxin:NADP+ reductase.
Biochemistry 1997;36(49):15109-17.
1997: Hurley J K; Weber-Main A M; Stankovich M T; Benning M M; Thoden J B; Vanhooke J L; Holden H M; Chae Y K; Xia B; Cheng H; Markley J L; Martinez-Júlvez M; Gómez-Moreno C; Schmeits J L; Tollin G
Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants.
Biochemistry 1997;36(37):11100-17.
1997: Thoden J B; Gulick A M; Holden H M
Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli.
Biochemistry 1997;36(35):10685-95.
1997: Liu Y; Thoden J B; Kim J; Berger E; Gulick A M; Ruzicka F J; Holden H M; Frey P A
Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli.
Biochemistry 1997;36(35):10675-84.
1997: Thoden J B; Holden H M; Wesenberg G; Raushel F M; Rayment I
Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product.
Biochemistry 1997;36(21):6305-16.
1997: Thoden J B; Hegeman A D; Wesenberg G; Chapeau M C; Frey P A; Holden H M
Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli.
Biochemistry 1997;36(21):6294-304.
1997: Thoden J B; Ruzicka F J; Frey P A; Rayment I; Holden H M
Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site.
Biochemistry 1997;36(6):1212-22.
1997: Thoden J B; Holden H M; Fisher A J; Sinclair J F; Wesenberg G; Baldwin T O; Rayment I
Structure of the beta 2 homodimer of bacterial luciferase from Vibrio harveyi: X-ray analysis of a kinetic protein folding trap.
Protein science : a publication of the Protein Society 1997;6(1):13-23.
1996: Holden H M; Wesenberg G; Raynes D A; Hartshorne D J; Guerriero V; Rayment I
Molecular structure of a proteolytic fragment of TLP20.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 6):1153-60.
1996: Thoden J B; Frey P A; Holden H M
High-resolution X-ray structure of UDP-galactose 4-epimerase complexed with UDP-phenol.
Protein science : a publication of the Protein Society 1996;5(11):2149-61.
1996: Benning M M; Meyer T E; Holden H M
Molecular structure of a high potential cytochrome c2 isolated from Rhodopila globiformis.
Archives of biochemistry and biophysics 1996;333(2):338-48.
1996: Benning M M; Taylor K L; Liu R-Q; Yang G; Xiang H; Wesenberg G; Dunaway-Mariano D; Holden H M
Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation.
Biochemistry 1996;35(25):8103-9.
1996: Vanhooke J L; Benning M M; Raushel F M; Holden H M
Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate.
Biochemistry 1996;35(19):6020-5.
1996: Thoden J B; Frey P A; Holden H M
Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism.
Biochemistry 1996;35(16):5137-44.
1996: Thoden J B; Frey P A; Holden H M
Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli.
Biochemistry 1996;35(8):2557-66.
1995: Pedersen L C; Benning M M; Holden H M
Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase.
Biochemistry 1995;34(41):13305-11.
1995: Fisher A J; Smith C A; Thoden J B; Smith R; Sutoh K; Holden H M; Rayment I
X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-.
Biochemistry 1995;34(28):8960-72.
1995: Benning M M; Kuo J M; Raushel F M; Holden H M
Three-dimensional structure of the binuclear metal center of phosphotriesterase.
Biochemistry 1995;34(25):7973-8.
1995: Fisher A J; Smith C A; Thoden J; Smith R; Sutoh K; Holden H M; Rayment I
Structural studies of myosin:nucleotide complexes: a revised model for the molecular basis of muscle contraction.
Biophysical journal 1995;68(4 Suppl):19S-26S; discussion 27S-28S.
1995: Hurley J K; Caffrey M S; Markley J L; Cheng H; Xia B; Chae Y K; Holden H M; Tollin G
Mutations of surface residues in Anabaena vegetative and heterocyst ferredoxin that affect thermodynamic stability as determined by guanidine hydrochloride denaturation.
Protein science : a publication of the Protein Society 1995;4(1):58-64.
1994: Benning M M; Kuo J M; Raushel F M; Holden H M
Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents.
Biochemistry 1994;33(50):15001-7.
1994: Haunerland N H; Jacobson B L; Wesenberg G; Rayment I; Holden H M
Three-dimensional structure of the muscle fatty-acid-binding protein isolated from the desert locust Schistocerca gregaria.
Biochemistry 1994;33(41):12378-85.
1994: Waldrop G L; Rayment I; Holden H M
Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase.
Biochemistry 1994;33(34):10249-56.
1994: Larsen T M; Laughlin L T; Holden H M; Rayment I; Reed G H
Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate.
Biochemistry 1994;33(20):6301-9.
1994: Benning M M; Meyer T E; Holden H M
X-Ray structure of the cytochrome c2 isolated from Paracoccus denitrificans refined to 1.7-A resolution.
Archives of biochemistry and biophysics 1994;310(2):460-6.
1994: Benning M M; Meyer T E; Rayment I; Holden H M
Molecular structure of the oxidized high-potential iron-sulfur protein isolated from Ectothiorhodospira vacuolata.
Biochemistry 1994;33(9):2476-83.
1994: Holden H M; Jacobson B L; Hurley J K; Tollin G; Oh B H; Skjeldal L; Chae Y K; Cheng H; Xia B; Markley J L
Structure-function studies of [2Fe-2S] ferredoxins.
Journal of bioenergetics and biomembranes 1994;26(1):67-88.
1994: Waldrop G; Holden H M; Rayment I
Preliminary X-ray crystallographic analysis of biotin carboxylase isolated from Escherichia coli.
Journal of molecular biology 1994;235(1):367-9.
1993: Sakon J; Liao H H; Kanikula A M; Benning M M; Rayment I; Holden H M
Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-A resolution.
Biochemistry 1993;32(45):11977-84.
1993: Rypniewski W R; Holden H M; Rayment I
Structural consequences of reductive methylation of lysine residues in hen egg white lysozyme: an X-ray analysis at 1.8-A resolution.
Biochemistry 1993;32(37):9851-8.
1993: Jacobson B L; Chae Y K; Markley J L; Rayment I; Holden H M
Molecular structure of the oxidized, recombinant, heterocyst [2Fe-2S] ferredoxin from Anabaena 7120 determined to 1.7-A resolution.
Biochemistry 1993;32(26):6788-93.
1993: Rayment I; Holden H M; Whittaker M; Yohn C B; Lorenz M; Holmes K C; Milligan R A
Structure of the actin-myosin complex and its implications for muscle contraction.
Science (New York, N.Y.) 1993;261(5117):58-65.
1993: Rayment I; Rypniewski W R; Schmidt-Bäse K; Smith R; Tomchick D R; Benning M M; Winkelmann D A; Wesenberg G; Holden H M
Three-dimensional structure of myosin subfragment-1: a molecular motor.
Science (New York, N.Y.) 1993;261(5117):50-8.
1992: Rayment I; Wesenberg G; Meyer T E; Cusanovich M A; Holden H M
Three-dimensional structure of the high-potential iron-sulfur protein isolated from the purple phototrophic bacterium Rhodocyclus tenuis determined and refined at 1.5 A resolution.
Journal of molecular biology 1992;228(2):672-86.
1992: Benning M M; Smith A F; Wells M A; Holden H M
Crystallization, structure determination and least-squares refinement to 1.75 A resolution of the fatty-acid-binding protein isolated from Manduca sexta L.
Journal of molecular biology 1992;228(1):208-19.
1992: Holden H M; Ito M; Hartshorne D J; Rayment I
X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.
Journal of molecular biology 1992;227(3):840-51.
1992: Kanikula A M; Liao H H; Sakon J; Holden H M; Rayment I
Crystallization and preliminary crystallographic analysis of a thermostable mutant of kanamycin nucleotidyltransferase.
Archives of biochemistry and biophysics 1992;295(1):1-4.
1992: Bauer A J; Rayment I; Frey P A; Holden H M
The molecular structure of UDP-galactose 4-epimerase from Escherichia coli determined at 2.5 A resolution.
Proteins 1992;12(4):372-81.
1992: Jacobson B L; Chae Y K; Böhme H; Markley J L; Holden H M
Crystallization and preliminary analysis of oxidized, recombinant, heterocyst [2Fe-2S] ferredoxin from Anabaena 7120.
Archives of biochemistry and biophysics 1992;294(1):279-81.
1992: Frey P A; Bauer A J; Vanhooke J L; Konopka J M; Rayment I; Holden H M
Chemical spectroscopic and crystallographic studies of UDP-galactose 4-epimerase from Escherichia coli.
Journal of nutritional science and vitaminology 1992;Spec No():461-4.
1991: Holden H M; Rayment I
Trimethyllead acetate: a first-choice heavy atom derivative for protein crystallography.
Archives of biochemistry and biophysics 1991;291(1):187-94.
1991: Breiter D R; Meyer T E; Rayment I; Holden H M
The molecular structure of the high potential iron-sulfur protein isolated from Ectothiorhodospira halophila determined at 2.5-A resolution.
The Journal of biological chemistry 1991;266(28):18660-7.
1991: Benning M M; Wesenberg G; Caffrey M S; Bartsch R G; Meyer T E; Cusanovich M A; Rayment I; Holden H M
Molecular structure of cytochrome c2 isolated from Rhodobacter capsulatus determined at 2.5 A resolution.
Journal of molecular biology 1991;220(3):673-85.
1991: Skjeldal L; Westler W M; Oh B H; Krezel A M; Holden H M; Jacobson B L; Rayment I; Markley J L
Two-dimensional magnetization exchange spectroscopy of Anabaena 7120 ferredoxin. Nuclear Overhauser effect and electron self-exchange cross peaks from amino acid residues surrounding the 2Fe-2S* cluster.
Biochemistry 1991;30(30):7363-8.
1991: Rypniewski W R; Breiter D R; Benning M M; Wesenberg G; Oh B H; Markley J L; Rayment I; Holden H M
Crystallization and structure determination to 2.5-A resolution of the oxidized [2Fe-2S] ferredoxin isolated from Anabaena 7120.
Biochemistry 1991;30(17):4126-31.
1991: Caffrey M S; Daldal F; Holden H M; Cusanovich M A
Importance of a conserved hydrogen-bonding network in cytochromes c to their redox potentials and stabilities.
Biochemistry 1991;30(17):4119-25.
1991: Breiter D R; Kanost M R; Benning M M; Wesenberg G; Law J H; Wells M A; Rayment I; Holden H M
Molecular structure of an apolipoprotein determined at 2.5-A resolution.
Biochemistry 1991;30(3):603-8.
1991: Bauer A J; Rayment I; Frey P A; Holden H M
The isolation, purification, and preliminary crystallographic characterization of UDP-galactose-4-epimerase from Escherichia coli.
Proteins 1991;9(2):135-42.
1988: Holden H M; Kanost M R; Law J H; Rayment I; Wells M A
Crystallization and preliminary analysis of crystals of apolipophorin III isolated from Locusta migratoria.
The Journal of biological chemistry 1988;263(8):3960-2.
1987: Holden H M; Rypniewski W R; Law J H; Rayment I
The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.
The EMBO journal 1987;6(6):1565-70.
1987: Holden H M; Meyer T E; Cusanovich M A; Daldal F; Rayment I
Crystallization and preliminary analysis of crystals of cytochrome c2 from Rhodopseudomonas capsulata.
Journal of molecular biology 1987;195(1):229-31.

Sign-in to see more