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Stephen Holgate

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Disorders

Anatomy

Phenomena

Forced Expiratory Volume

Procedures

Chemicals & Drugs

Physiology

Bronchoconstriction

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Publications

TOP 3
Holgate S; Smith N; Massanari M; Jimenez P
Effects of omalizumab on markers of inflammation in patients with allergic asthma.
Koppelman Gerard H; Meyers Deborah A; Howard Timothy D; Zheng S Lilly; Hawkins Greg A; Ampleford Elizabeth J; Xu Jianfeng; Koning Henk; Bruinenberg Marcel; Nolte Ilja M; van Diemen Cleo C; Boezen H Marike; Timens Wim; Whittaker Paul A; Stine O Colin; Barton Sheila J; Holloway John W; Holgate Stephen T; Graves Penelope E; Martinez Fernando D; van Oosterhout Antoon J; Bleecker Eugene R; Postma Dirkje S
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.
van Goor Harry; Melenhorst Wynand B W H; Turner Anthony J; Holgate Stephen T
Adamalysins in biology and disease.

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All Publications

2009: Holgate S; Smith N; Massanari M; Jimenez P
Effects of omalizumab on markers of inflammation in patients with allergic asthma.
Allergy 2009;64(12):1728-36.
2009: Koppelman Gerard H; Meyers Deborah A; Howard Timothy D; Zheng S Lilly; Hawkins Greg A; Ampleford Elizabeth J; Xu Jianfeng; Koning Henk; Bruinenberg Marcel; Nolte Ilja M; van Diemen Cleo C; Boezen H Marike; Timens Wim; Whittaker Paul A; Stine O Colin; Barton Sheila J; Holloway John W; Holgate Stephen T; Graves Penelope E; Martinez Fernando D; van Oosterhout Antoon J; Bleecker Eugene R; Postma Dirkje S
Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.
American journal of respiratory and critical care medicine 2009;180(10):929-35.
2009: van Goor Harry; Melenhorst Wynand B W H; Turner Anthony J; Holgate Stephen T
Adamalysins in biology and disease.
The Journal of pathology 2009;219(3):277-86.
2009: Holgate Stephen T; Davies Donna E
Rethinking the pathogenesis of asthma.
Immunity 2009;31(3):362-7.
2009: Haitchi Hans Michael; Bassett David J P; Bucchieri Fabio; Gao Xiufeng; Powell Robert M; Hanley Neil A; Wilson David I; Holgate Stephen T; Davies Donna E
Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.
The Journal of allergy and clinical immunology 2009;124(3):590-7, 597.e1-11.
2009: Yang I A; Fong K M; Zimmerman P V; Holgate S T; Holloway J W
Genetic susceptibility to the respiratory effects of air pollution.
Postgraduate medical journal 2009;85(1006):428-36.
2009: Andrews Allison-Lynn; Nordgren Ida Karin; Kirby Isabelle; Holloway John W; Holgate Stephen T; Davies Donna E; Tavassoli Ali
Cytoplasmic tail of IL-13Ralpha2 regulates IL-4 signal transduction.
Biochemical Society transactions 2009;37(Pt 4):873-6.
2009: Heffner John E; Holgate Stephen T; Chung Kian Fan; Niederman Michael S; Daley Charles L; Jett James R; Stradling John R; Wells Athol U; Light Richard W; Tapson Victor F; Hansell David M; Provonost Peter J; Lee Y C Gary
Road ahead to respiratory health: experts chart future research directions.
Respirology (Carlton, Vic.) 2009;14(5):625-36.
2009: Barton Sheila J; Koppelman Gerard H; Vonk Judith M; Browning Claudia A; Nolte Ilja M; Stewart Ceri E; Bainbridge Sue; Mutch Stacey; Rose-Zerilli Matthew J; Postma Dirkje S; Maniatis Nikolas; Henry Amanda P; Hall Ian P; Holgate Stephen T; Tighe Patrick; Holloway John W; Sayers Ian
PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.
The Journal of allergy and clinical immunology 2009;123(6):1391-400.e17.
2009: Haitchi H M; Yoshisue H; Ribbene A; Wilson S J; Holloway J W; Bucchieri F; Hanley N A; Wilson D I; Zummo G; Holgate S T; Davies D E
Chronological expression of Ciliated Bronchial Epithelium 1 during pulmonary development.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2009;33(5):1095-104.
2009: Wenzel Sally E; Barnes Peter J; Bleecker Eugene R; Bousquet Jean; Busse William; Dahlén Sven-Erik; Holgate Stephen T; Meyers Deborah A; Rabe Klaus F; Antczak Adam; Baker James; Horvath Ildiko; Mark Zsuzsanna; Bernstein David; Kerwin Edward; Schlenker-Herceg Rozsa; Lo Kim Hung; Watt Rosemary; Barnathan Elliot S; Chanez Pascal;
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma.
American journal of respiratory and critical care medicine 2009;179(7):549-58.
2009: Bedke Nicole; Haitchi Hans Michael; Xatzipsalti Mara; Holgate Stephen T; Davies Donna E
Contribution of bronchial fibroblasts to the antiviral response in asthma.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(6):3660-7.
2009: Knol Anne B; de Hartog Jeroen J; Boogaard Hanna; Slottje Pauline; van der Sluijs Jeroen P; Lebret Erik; Cassee Flemming R; Wardekker J Arjan; Ayres Jon G; Borm Paul J; Brunekreef Bert; Donaldson Kenneth; Forastiere Francesco; Holgate Stephen T; Kreyling Wolfgang G; Nemery Benoit; Pekkanen Juha; Stone Vicky; Wichmann H-Erich; Hoek Gerard
Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways.
Particle and fibre toxicology 2009;6():19.
2009: Szczepankiewicz Aleksandra; Rose-Zerilli Matthew J; Barton Sheila J; Holgate Stephen T; Holloway John W
Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families.
International archives of allergy and immunology 2009;149(4):343-9.
2008: Holgate S; Bisgaard H; Bjermer L; Haahtela T; Haughney J; Horne R; McIvor A; Palkonen S; Price D B; Thomas M; Valovirta E; Wahn U
The Brussels Declaration: the need for change in asthma management.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;32(6):1433-42.
2008: Pemberton Alan D; Rose-Zerilli Matthew J; Holloway John W; Gray Robert D; Holgate Stephen T
A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk.
The Journal of allergy and clinical immunology 2008;122(5):1033-4.
2008: Holgate Stephen T
Are long-acting beta2-agonists safe in the treatment of asthma?
Polskie archiwum medycyny wewn?trznej 2008;118(9):460-1.
2008: Sheikh Aziz; Major Philippa; Holgate Stephen T
Developing consensus on national respiratory research priorities: key findings from the UK Respiratory Research Collaborative's e-Delphi exercise.
Respiratory medicine 2008;102(8):1089-92.
2008: Holloway J W; Barton S J; Holgate S T; Rose-Zerilli M J; Sayers I
The role of LTA4H and ALOX5AP polymorphism in asthma and allergy susceptibility.
Allergy 2008;63(8):1046-53.
2008: Babu K Suresh; Gadzik Frantisek; Holgate Stephen T
Absence of respiratory effects with ivabradine in patients with asthma.
British journal of clinical pharmacology 2008;66(1):96-101.
2008: Morjaria J B; Chauhan A J; Babu K S; Polosa R; Davies D E; Holgate S T
The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial.
Thorax 2008;63(7):584-91.
2008: Yang I A; Fong K M; Zimmerman P V; Holgate S T; Holloway J W
Genetic susceptibility to the respiratory effects of air pollution.
Thorax 2008;63(6):555-63.
2008: Holgate Stephen T
Pathogenesis of asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2008;38(6):872-97.
2008: Yang Youwen; Haitchi Hans Michael; Cakebread Julie; Sammut David; Harvey Anna; Powell Robert M; Holloway John W; Howarth Peter; Holgate Stephen T; Davies Donna E
Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.
The Journal of allergy and clinical immunology 2008;121(6):1393-9, 1399.e1-14.
2008: Puxeddu Ilaria; Pang Yun Yun; Harvey Anna; Haitchi Hans Michael; Nicholas Ben; Yoshisue Hajime; Ribatti Domenico; Clough Geraldine; Powell Rob M; Murphy Gillian; Hanley Neil A; Wilson David I; Howarth Peter H; Holgate Stephen T; Davies Donna E
The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.
The Journal of allergy and clinical immunology 2008;121(6):1400-6, 1406.e1-4.
2008: Kerr Jonathan R; Petty Robert; Burke Beverley; Gough John; Fear David; Sinclair Lindsey I; Mattey Derek L; Richards Selwyn C M; Montgomery Jane; Baldwin Don A; Kellam Paul; Harrison Tim J; Griffin George E; Main Janice; Enlander Derek; Nutt David J; Holgate Stephen T
Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.
The Journal of infectious diseases 2008;197(8):1171-84.
2008: Holloway John W; Yang Ian A; Holgate Stephen T
Interpatient variability in rates of asthma progression: can genetics provide an answer?
The Journal of allergy and clinical immunology 2008;121(3):573-9.
2008: Holgate Stephen T; Polosa Riccardo
Treatment strategies for allergy and asthma.
Nature reviews. Immunology 2008;8(3):218-30.
2008: Holgate Stephen T
The airway epithelium is central to the pathogenesis of asthma.
Allergology international : official journal of the Japanese Society of Allergology 2008;57(1):1-10.
2008: Sheldon Trevor; Holgate Stephen T
Is artificial fluoride absorbed to the same extent as natural fluoride?
Journal of dental research 2008;87(1):8; author reply 8.
2008: Konstantinidis A K; Puddicombe S M; Mochizuki A; Sheth P D; Yang I A; Yoshisue H; Wilson S J; Davies D E; Holgate S T; Holloway J W
Cellular localization of interleukin 13 receptor alpha2 in human primary bronchial epithelial cells and fibroblasts.
Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología 2008;18(3):174-80.
2008: Hackett Tillie-Louise; Holloway Rebecca; Holgate Stephen T; Warner Jane A
Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study.
Respiratory research 2008;9():47.
2008: Pourazar Jamshid; Blomberg Anders; Kelly Frank J; Davies Donna E; Wilson Susan J; Holgate Stephen T; Sandström Thomas
Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium.
Particle and fibre toxicology 2008;5():8.
2007: Holgate Stephen T
Epithelium dysfunction in asthma.
The Journal of allergy and clinical immunology 2007;120(6):1233-44; quiz 1245-6.
2007: Holgate Stephen T
The future of lung research in the UK.
Thorax 2007;62(12):1028-32.
2007: Holgate Stephen T; Sheldon Trevor A
Fluoridation: Interpreting the Newcastle fluoride bioavailability study.
BMJ (Clinical research ed.) 2007;335(7625):840-1.
2007: Langley Gill; Evans Tom; Holgate Stephen T; Jones Anthony
Replacing animal experiments: choices, chances and challenges.
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(9):918-26.
2007: Wark Peter A B; Bucchieri Fabio; Johnston Sebastian L; Gibson Peter G; Hamilton Lynnsey; Mimica Joanna; Zummo Giovanni; Holgate Stephen T; Attia John; Thakkinstian Ammarin; Davies Donna E
IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations.
The Journal of allergy and clinical immunology 2007;120(3):586-93.
2007: Watson Louise; Turk Florian; James Philip; Holgate Stephen T
Factors associated with mortality after an asthma admission: a national United Kingdom database analysis.
Respiratory medicine 2007;101(8):1659-64.
2007: Andrews Allison-Lynn; Bucchieri Fabio; Arima Kazuhiko; Izuhara Kenji; Holgate Stephen T; Davies Donna E; Holloway John W
Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q.
The Journal of allergy and clinical immunology 2007;120(1):91-7.
2007: Konstantinidis A K; Barton S J; Sayers I; Yang I A; Lordan J L; Rorke S; Clough J B; Holgate S T; Holloway J W
Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;30(1):40-7.
2007: Bousquet J; Rabe K; Humbert M; Chung K F; Berger W; Fox H; Ayre G; Chen H; Thomas K; Blogg M; Holgate S
Predicting and evaluating response to omalizumab in patients with severe allergic asthma.
Respiratory medicine 2007;101(7):1483-92.
2007: Jame A J; Lackie P M; Cazaly A M; Sayers I; Penrose J F; Holgate S T; Sampson A P
Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2007;37(6):880-92.
2007: Holgate Stephen T
The epithelium takes centre stage in asthma and atopic dermatitis.
Trends in immunology 2007;28(6):248-51.
2007: Chanez Pascal; Wenzel Sally E; Anderson Gary P; Anto Josep M; Bel Elisabeth H; Boulet Louis-Philippe; Brightling Christopher E; Busse William W; Castro Mario; Dahlen Babro; Dahlen Sven Erik; Fabbri Leo M; Holgate Stephen T; Humbert Marc; Gaga Mina; Joos Guy F; Levy Bruce; Rabe Klaus F; Sterk Peter J; Wilson Susan J; Vachier Isabelle
Severe asthma in adults: what are the important questions?
The Journal of allergy and clinical immunology 2007;119(6):1337-48.
2007: Holgate S T; Davies D E; Powell R M; Howarth P H; Haitchi H M; Holloway J W
Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2007;29(4):793-803.
2007: Pierrou Stefan; Broberg Per; O'Donnell Rory A; Pawlowski Krzysztof; Virtala Robert; Lindqvist Eva; Richter Audrey; Wilson Susan J; Angco Gilbert; Möller Sebastian; Bergstrand Håkan; Koopmann Witte; Wieslander Elisabet; Strömstedt Per-Erik; Holgate Stephen T; Davies Donna E; Lund Johan; Djukanovic Ratko
Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine 2007;175(6):577-86.
2007: Adam Elizabeth C; Holgate Stephen T; Lackie Peter M
Epithelial repair is inhibited by an alpha(1,6)-fucose binding lectin.
American journal of physiology. Lung cellular and molecular physiology 2007;292(2):L462-8.
2007: Yoshisue Hajime; Kirkham-Brown Jody; Healy Eugene; Holgate Stephen T; Sampson Anthony P; Davies Donna E
Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts.
The Journal of allergy and clinical immunology 2007;119(1):132-40.
2007: Holgate Stephen T
Priorities for respiratory research in the UK.
Thorax 2007;62(1):5-7.
2006: Radcliffe Michael J; Lewith George T; Prescott Philip; Church Martin K; Holgate Stephen T
Do skin prick and conjunctival provocation tests predict symptom severity in seasonal allergic rhinoconjunctivitis?
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(12):1488-93.
2006: Wenzel Sally; Holgate Stephen T
The mouse trap: It still yields few answers in asthma.
American journal of respiratory and critical care medicine 2006;174(11):1173-6; discussion 1176-8.
2006: Andrews Allison-Lynn; Nasir Tosia; Bucchieri Fabio; Holloway John W; Holgate Stephen T; Davies Donna E
IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts.
The Journal of allergy and clinical immunology 2006;118(4):858-65.
2006: Holgate Stephen T
Rhinoviruses in the pathogenesis of asthma: the bronchial epithelium as a major disease target.
The Journal of allergy and clinical immunology 2006;118(3):587-90.
2006: Contoli Marco; Message Simon D; Laza-Stanca Vasile; Edwards Michael R; Wark Peter A B; Bartlett Nathan W; Kebadze Tatiana; Mallia Patrick; Stanciu Luminita A; Parker Hayley L; Slater Louise; Lewis-Antes Anita; Kon Onn M; Holgate Stephen T; Davies Donna E; Kotenko Sergei V; Papi Alberto; Johnston Sebastian L
Role of deficient type III interferon-lambda production in asthma exacerbations.
Nature medicine 2006;12(9):1023-6.
2006: Holgate Stephen T; Polosa Riccardo
The mechanisms, diagnosis, and management of severe asthma in adults.
Lancet 2006;368(9537):780-93.
2006: Holgate Stephen T
Susceptibility genes in severe asthma.
Current allergy and asthma reports 2006;6(4):345-8.
2006: Holgate Stephen T; Yang Youwen; Haitchi Hans-Michael; Powell Rob M; Holloway John W; Yoshisue Hajime; Pang Yun Yun; Cakebread Julie; Davies Donna E
The genetics of asthma: ADAM33 as an example of a susceptibility gene.
Proceedings of the American Thoracic Society 2006;3(5):440-3.
2006: Polosa Riccardo; Holgate Stephen T
Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation.
Current drug targets 2006;7(6):699-706.
2006: Hao L; Sayers I; Cakebread J A; Barton S J; Beghé B; Holgate S T; Sampson A P; Holloway J W
The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(6):735-41.
2006: Andrews Allison-Lynn; Holloway John W; Holgate Stephen T; Davies Donna E
IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7456-61.
2006: Bradding Peter; Walls Andrew F; Holgate Stephen T
The role of the mast cell in the pathophysiology of asthma.
The Journal of allergy and clinical immunology 2006;117(6):1277-84.
2006: Caruso Massimo; Holgate Stephen T; Polosa Riccardo
Adenosine signalling in airways.
Current opinion in pharmacology 2006;6(3):251-6.
2006: Wicks J; Haitchi H M; Holgate S T; Davies D E; Powell R M
Enhanced upregulation of smooth muscle related transcripts by TGF beta2 in asthmatic (myo) fibroblasts.
Thorax 2006;61(4):313-9.
2006: Holgate Stephen T; Holloway John; Wilson Susan; Howarth Peter H; Haitchi Hans Michael; Babu Suresh; Davies Donna E
Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.
The Journal of allergy and clinical immunology 2006;117(3):496-506; quiz 507.
2006: Yang Ian A; Fong Kwun M; Holgate Stephen T; Holloway John W
The role of Toll-like receptors and related receptors of the innate immune system in asthma.
Current opinion in allergy and clinical immunology 2006;6(1):23-8.
2006: Boxall C; Holgate S T; Davies D E
The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2006;27(1):208-29.
2006: Price David; Holgate Stephen T
Improving outcomes for asthma patients with allergic rhinitis: conclusions from the MetaForum conferences.
BMC pulmonary medicine 2006;6 Suppl 1():S7.
2006: Holgate Stephen T; Price David; Valovirta Erkka
Asthma out of control? A structured review of recent patient surveys.
BMC pulmonary medicine 2006;6 Suppl 1():S2.
2006: James Anna J; Penrose John F; Cazaly Angelica M; Holgate Stephen T; Sampson Anthony P
Human bronchial fibroblasts express the 5-lipoxygenase pathway.
Respiratory research 2006;7():102.
2006: Holgate Stephen T; Davies Donna E; Powell Rob M; Holloway John W
ADAM33: a newly identified protease involved in airway remodelling.
Pulmonary pharmacology & therapeutics 2006;19(1):3-11.
2005: Howarth P H; Babu K S; Arshad H S; Lau L; Buckley M; McConnell W; Beckett P; Al Ali M; Chauhan A; Wilson S J; Reynolds A; Davies D E; Holgate S T
Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma.
Thorax 2005;60(12):1012-8.
2005: Holgate Stephen T; Davies Donna E; Powell Rob M; Holloway John W
ADAM33: a newly identified gene in the pathogenesis of asthma.
Immunology and allergy clinics of North America 2005;25(4):655-68.
2005: Holgate Stephen T
Exacerbations: the asthma paradox.
American journal of respiratory and critical care medicine 2005;172(8):941-3.
2005: de Bilderling Georges; Chauhan Anoop J; Jeffs Jim A R; Withers Nicholas; Johnston Sebastian L; Holgate Stephen T; Clough Joanne B
Gas cooking and smoking habits and the risk of childhood and adolescent wheeze.
American journal of epidemiology 2005;162(6):513-22.
2005: Holgate S T; Lack G
Improving the management of atopic disease.
Archives of disease in childhood 2005;90(8):826-31.
2005: Holgate Stephen T
The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma.
British journal of pharmacology 2005;145(8):1009-15.
2005: Simpson Angela; Maniatis Nikolas; Jury Francine; Cakebread Julie A; Lowe Lesley A; Holgate Stephen T; Woodcock Ashley; Ollier William E R; Collins Andrew; Custovic Adnan; Holloway John W; John Sally L
Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function.
American journal of respiratory and critical care medicine 2005;172(1):55-60.
2005: Hamilton L M; Puddicombe S M; Dearman R J; Kimber I; Sandström T; Wallin A; Howarth P H; Holgate S T; Wilson S J; Davies D E
Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2005;25(6):978-85.
2005: Steel Mark D; Puddicombe Sarah M; Hamilton Lynnsey M; Powell Rob M; Holloway John W; Holgate Stephen T; Davies Donna E; Collins Jane E
Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells.
The international journal of biochemistry & cell biology 2005;37(6):1281-95.
2005: Bruton Anne; Holgate Stephen T
Hypocapnia and asthma: a mechanism for breathing retraining?
Chest 2005;127(5):1808-11.
2005: Haitchi Hans Michael; Powell Robert M; Shaw Timothy J; Howarth Peter H; Wilson Susan J; Wilson David I; Holgate Stephen T; Davies Donna E
ADAM33 expression in asthmatic airways and human embryonic lungs.
American journal of respiratory and critical care medicine 2005;171(9):958-65.
2005: Holgate S T; Djukanovic R; Casale T; Bousquet J
Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005;35(4):408-16.
2005: Wark Peter A B; Johnston Sebastian L; Bucchieri Fabio; Powell Robert; Puddicombe Sarah; Laza-Stanca Vasile; Holgate Stephen T; Davies Donna E
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus.
The Journal of experimental medicine 2005;201(6):937-47.
2005: Bousquet J; Cabrera P; Berkman N; Buhl R; Holgate S; Wenzel S; Fox H; Hedgecock S; Blogg M; Cioppa G Della
The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma.
Allergy 2005;60(3):302-8.
2005: Cho Sang-Heon; Stanciu Luminita A; Holgate Stephen T; Johnston Sebastian L
Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma.
American journal of respiratory and critical care medicine 2005;171(3):224-30.
2005: Yang Ian A; Holz Olaf; Jörres Rudolf A; Magnussen Helgo; Barton Sheila J; Rodríguez Santiago; Cakebread Julie A; Holloway John W; Holgate Stephen T
Association of tumor necrosis factor-alpha polymorphisms and ozone-induced change in lung function.
American journal of respiratory and critical care medicine 2005;171(2):171-6.
2005: Stanciu Luminita A; Roberts Kevan; Papadopoulos Nikolaos G; Cho Sang-Heon; Holgate Stephen T; Coyle Anthony J; Johnston Sebastian L
IL-4 increases type 2, but not type 1, cytokine production in CD8+ T cells from mild atopic asthmatics.
Respiratory research 2005;6():67.
2004: O'Donnell R A; Richter A; Ward J; Angco G; Mehta A; Rousseau K; Swallow D M; Holgate S T; Djukanovic R; Davies D E; Wilson S J
Expression of ErbB receptors and mucins in the airways of long term current smokers.
Thorax 2004;59(12):1032-40.
2004: Holgate Stephen T
Cytokine and anti-cytokine therapy for the treatment of asthma and allergic disease.
Cytokine 2004;28(4-5):152-7.
2004: Babu K Suresh; Davies Donna E; Holgate Stephen T
Role of tumor necrosis factor alpha in asthma.
Immunology and allergy clinics of North America 2004;24(4):583-97, v-vi.
2004: Yoshisue Hajime; Puddicombe Sarah M; Wilson Susan J; Haitchi Hans Michael; Powell Robert M; Wilson David I; Pandit Anita; Berger Ann E; Davies Donna E; Holgate Stephen T; Holloway John W
Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation.
American journal of respiratory cell and molecular biology 2004;31(5):491-500.
2004: O'Donnell R A; Peebles C; Ward J A; Daraker A; Angco G; Broberg P; Pierrou S; Lund J; Holgate S T; Davies D E; Delany D J; Wilson S J; Djukanovic R
Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD.
Thorax 2004;59(10):837-42.
2004: Djukanovic Ratko; Wilson Susan J; Kraft Monica; Jarjour Nizar N; Steel Mark; Chung K Fan; Bao Weibin; Fowler-Taylor Angel; Matthews John; Busse William W; Holgate Stephen T; Fahy John V
Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma.
American journal of respiratory and critical care medicine 2004;170(6):583-93.
2004: Holloway John W; Davies Donna E; Powell Robert; Haitchi Hans-Michael; Keith Tim P; Holgate Stephen T
The discovery and role of ADAM33, a new candidate gene for asthma.
Expert reviews in molecular medicine 2004;6(17):1-12.
2004: Holgate Stephen T; Davies Donna E; Rorke Steuart; Cakebread Julie; Murphy Gillian; Powell Robert M; Holloway John W
ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma.
Clinical reviews in allergy & immunology 2004;27(1):23-34.
2004: Holgate Stephen T
Genetic common ground between allergic and autoimmune disease: The role of cytotoxic T-lymphocyte antigen 4.
The Journal of allergy and clinical immunology 2004;114(2):277-9.
2004: Coward W R; Sagara H; Wilson S J; Holgate S T; Church M K
Allergen activates peripheral blood eosinophil nuclear factor-kappaB to generate granulocyte macrophage-colony stimulating factor, tumour necrosis factor-alpha and interleukin-8.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(7):1071-8.
2004: Iwanaga T; McEuen A; Walls A F; Clough J B; Keith T P; Rorke S; Barton S J; Holgate S T; Holloway J W
Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(7):1037-42.
2004: Powell Robert M; Wicks James; Holloway John W; Holgate Stephen T; Davies Donna E
The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts.
American journal of respiratory cell and molecular biology 2004;31(1):13-21.
2004: Holgate S T; Bousquet J; Chung K F; Bisgaard H; Pauwels R; Fabbri L; Rabe K; Doherty M; Snell N J C; Cuss F; D'Amato M; Reginster J Y;
Summary of recommendations for the design of clinical trials and the registration of drugs used in the treatment of asthma.
Respiratory medicine 2004;98(6):479-87.
2004: Holgate S T
Lessons learnt from the epidemic of asthma.
QJM : monthly journal of the Association of Physicians 2004;97(5):247-57.
2004: Holgate S T; Chuchalin A G; Hébert J; Lötvall J; Persson G B; Chung K F; Bousquet J; Kerstjens H A; Fox H; Thirlwell J; Cioppa G Della;
Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2004;34(4):632-8.
2004: Holgate Stephen T
The epidemic of asthma and allergy.
Journal of the Royal Society of Medicine 2004;97(3):103-10.
2004: Holgate Stephen T
Pharmacogenetics: the new science of personalizing treatment.
Current opinion in allergy and clinical immunology 2004;4(1):37-8.
2004: Cakebread Julie A; Haitchi H-M; Holloway John W; Powell Robert M; Keith Tim; Davies Donna E; Holgate Stephen T
The role of ADAM33 in the pathogenesis of asthma.
Springer seminars in immunopathology 2004;25(3-4):361-75.
2004: Haitchi Hans Michael; Holgate Stephen T
New strategies in the treatment and prevention of allergic diseases.
Expert opinion on investigational drugs 2004;13(2):107-24.
2004: Stenfors N; Nordenhäll C; Salvi S S; Mudway I; Söderberg M; Blomberg A; Helleday R; Levin J O; Holgate S T; Kelly F J; Frew A J; Sandström T
Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2004;23(1):82-6.
2004: Yang I A; Barton S J; Rorke S; Cakebread J A; Keith T P; Clough J B; Holgate S T; Holloway J W
Toll-like receptor 4 polymorphism and severity of atopy in asthmatics.
Genes and immunity 2004;5(1):41-5.
2004: Polosa Riccardo; Sapsford Raymond J; Dokic Dejan; Cacciola Rossella R; Prosperini Gaetano; Devalia Jagdish L; Holgate Stephen T; Howarth Peter H; Davies Donna E
Induction of the epidermal growth factor receptor and its ligands in nasal epithelium by ozone.
The Journal of allergy and clinical immunology 2004;113(1):120-6.
2004: Beghé B; Padoan M; Moss C T; Barton S J; Holloway J W; Holgate S T; Howell W M; Mapp C E
Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma.
Allergy 2004;59(1):61-4.
2004: Holgate Stephen T; Holloway John; Wilson Susan; Bucchieri Fabio; Puddicombe Sarah; Davies Donna E
Epithelial-mesenchymal communication in the pathogenesis of chronic asthma.
Proceedings of the American Thoracic Society 2004;1(2):93-8.
2004: Holloway John W; Holgate Stephen T
Genetics.
Chemical immunology and allergy 2004;84():1-35.
2003: Holgate Stephen T; Devlin Robert B; Wilson Susan J; Frew Anthony J
Health effects of acute exposure to air pollution. Part II: Healthy subjects exposed to concentrated ambient particles.
Research report (Health Effects Institute) 2003;(112):31-50; discussion 51-67.
2003: Holgate Stephen T; Sandström Thomas; Frew Anthony J; Stenfors Nikolai; Nördenhall Charlotta; Salvi Sundeep; Blomberg Anders; Helleday Ragnberth; Söderberg Margaretha
Health effects of acute exposure to air pollution. Part I: Healthy and asthmatic subjects exposed to diesel exhaust.
Research report (Health Effects Institute) 2003;(112):1-30; discussion 51-67.
2003: Knight Darryl A; Holgate Stephen T
The airway epithelium: structural and functional properties in health and disease.
Respirology (Carlton, Vic.) 2003;8(4):432-46.
2003: Brightling C E; Symon F A; Holgate S T; Wardlaw A J; Pavord I D; Bradding P
Interleukin-4 and -13 expression is co-localized to mast cells within the airway smooth muscle in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(12):1711-6.
2003: Leir Shih-Hsing; Holgate Stephen T; Lackie Peter M
Inflammatory cytokines can enhance CD44-mediated airway epithelial cell adhesion independently of CD44 expression.
American journal of physiology. Lung cellular and molecular physiology 2003;285(6):L1305-11.
2003: Holgate Stephen T; Broide David
New targets for allergic rhinitis--a disease of civilization.
Nature reviews. Drug discovery 2003;2(11):902-14.
2003: Pathmanathan S; Krishna M T; Blomberg A; Helleday R; Kelly F J; Sandström T; Holgate S T; Wilson S J; Frew A J
Repeated daily exposure to 2 ppm nitrogen dioxide upregulates the expression of IL-5, IL-10, IL-13, and ICAM-1 in the bronchial epithelium of healthy human airways.
Occupational and environmental medicine 2003;60(11):892-6.
2003: Bjermer Leif; Bisgaard Hans; Bousquet Jean; Fabbri Leonardo M; Greening Andrew P; Haahtela Tari; Holgate Stephen T; Picado Cesar; Menten Joris; Dass S Balachandra; Leff Jonathan A; Polos Peter G
Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial.
BMJ (Clinical research ed.) 2003;327(7420):891.
2003: Adam E C; Holgate S T; Fildew C J; Lackie P M
Role of carbohydrates in repair of human respiratory epithelium using an in vitro model.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(10):1398-404.
2003: Holgate S T; Davies D E; Puddicombe S; Richter A; Lackie P; Lordan J; Howarth P
Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma.
The European respiratory journal. Supplement 2003;44():24s-29s.
2003: Holgate S T; Canonica G W; Simons F E R; Taglialatela M; Tharp M; Timmerman H; Yanai K;
Consensus Group on New-Generation Antihistamines (CONGA): present status and recommendations.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(9):1305-24.
2003: Beghé B; Barton S; Rorke S; Peng Q; Sayers I; Gaunt T; Keith T P; Clough J B; Holgate S T; Holloway J W
Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(8):1111-7.
2003: Sayers I; Barton S; Rorke S; Sawyer J; Peng Q; Beghé B; Ye S; Keith T; Clough J B; Holloway J W; Sampson A P; Holgate S T
Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(8):1103-10.
2003: Radcliffe Michael J; Lewith George T; Turner Richard G; Prescott Philip; Church Martin K; Holgate Stephen T
Enzyme potentiated desensitisation in treatment of seasonal allergic rhinitis: double blind randomised controlled study.
BMJ (Clinical research ed.) 2003;327(7409):251-4.
2003: Powell Robert M; Hamilton Lynnsey M; Holgate Stephen T; Davies Donna E; Holloway John W
ADAM33: a novel therapeutic target for asthma.
Expert opinion on therapeutic targets 2003;7(4):485-94.
2003: Chauhan A J; Inskip Hazel M; Linaker Catherine H; Smith Sandra; Schreiber Jacqueline; Johnston Sebastian L; Holgate Stephen T
Personal exposure to nitrogen dioxide (NO2) and the severity of virus-induced asthma in children.
Lancet 2003;361(9373):1939-44.
2003: Bosson J; Stenfors N; Bucht A; Helleday R; Pourazar J; Holgate S T; Kelly F J; Sandström T; Wilson S; Frew A J; Blomberg A
Ozone-induced bronchial epithelial cytokine expression differs between healthy and asthmatic subjects.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(6):777-82.
2003: Babu K S; Woodcock D A; Smith S E; Staniforth J N; Holgate S T; Conway J H
Inhaled synthetic surfactant abolishes the early allergen-induced response in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(6):1046-9.
2003: Watson Mark W; Beasley Richard; Holgate Stephen T; Bardin Philip G
Rhinovirus is not detectable in peripheral lung tissue after asthma death.
Respirology (Carlton, Vic.) 2003;8(2):234-8.
2003: Sayers I; Barton S; Rorke S; Beghé B; Hayward B; Van Eerdewegh P; Keith T; Clough J B; Ye S; Holloway J W; Sampson A P; Holgate S T
Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma.
Thorax 2003;58(5):417-24.
2003: Camporota L; Corkhill A; Long H; Lordan J; Stanciu L; Tuckwell N; Cross A; Stanford J L; Rook G A W; Holgate S T; Djukanovic R
The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2003;21(2):287-93.
2003: Davies Donna E; Wicks James; Powell Robert M; Puddicombe Sarah M; Holgate Stephen T
Airway remodeling in asthma: new insights.
The Journal of allergy and clinical immunology 2003;111(2):215-25; quiz 226.
2003: Hamilton L M; Torres-Lozano C; Puddicombe S M; Richter A; Kimber I; Dearman R J; Vrugt B; Aalbers R; Holgate S T; Djukanovic R; Wilson S J; Davies D E
The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(2):233-40.
2003: Sharma S; Lackie P M; Holgate S T
Uneasy breather: the implications of dust mite allergens.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(2):163-5.
2003: Holgate Stephen T; Peters-Golden Marc; Panettieri Reynold A; Henderson William R
Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling.
The Journal of allergy and clinical immunology 2003;111(1 Suppl):S18-34; discussion S34-6.
2003: Holgate Stephen T; Peters-Golden Marc
Introduction: the anti-inflammatory role of cysteinyl leukotriene receptor antagonists in asthma.
The Journal of allergy and clinical immunology 2003;111(1 Suppl):S1-4.
2003: Puddicombe Sarah M; Torres-Lozano Carlos; Richter Audrey; Bucchieri Fabio; Lordan James L; Howarth Peter H; Vrugt Bart; Albers Rene; Djukanovic Ratko; Holgate Stephen T; Wilson Susan J; Davies Donna E
Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium.
American journal of respiratory cell and molecular biology 2003;28(1):61-8.
2002: Krishna Mamidipudi T; Hatzivlassiou Prodromos; Salvi Sundeep S; Holgate Stephen T
Current and future asthma therapies.
The Practitioner 2002;246(1641):820-5.
2002: Wallin A; Sandström T; Cioppa G D; Holgate S; Wilson S
The effects of regular inhaled formoterol and budesonide on preformed Th-2 cytokines in mild asthmatics.
Respiratory medicine 2002;96(12):1021-5.
2002: Dent Gordon; Hosking Lisa A; Lordan James L; Steel Mark D; Cruikshank William W; Center David M; Ellis Jonathan H; Holgate Stephen T; Davies Donna E; Djukanovic Ratko
Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals.
The Journal of allergy and clinical immunology 2002;110(6):906-14.
2002: Prosperini Gaetano; Rajakulasingam Kajakulasingam; Cacciola Rossella R; Spicuzza Lucia; Rorke Steuart; Holgate Stephen T; Di Maria Giuseppe U; Polosa Riccardo
Changes in sputum counts and airway hyperresponsiveness after budesonide: monitoring anti-inflammatory response on the basis of surrogate markers of airway inflammation.
The Journal of allergy and clinical immunology 2002;110(6):855-61.
2002: Davies D E; Holgate S T
Asthma: the importance of epithelial mesenchymal communication in pathogenesis. Inflammation and the airway epithelium in asthma.
The international journal of biochemistry & cell biology 2002;34(12):1520-6.
2002: Papi Alberto; Papadopoulos Nikolaos G; Stanciu Luminita A; Bellettato Cinzia M; Pinamonti Silvano; Degitz Klaus; Holgate Stephen T; Johnston Sebastian L
Reducing agents inhibit rhinovirus-induced up-regulation of the rhinovirus receptor intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1934-6.
2002: Coward William R; Okayama Yoshimichi; Sagara Hironori; Wilson Susan J; Holgate Stephen T; Church Martin K
NF-kappa B and TNF-alpha: a positive autocrine loop in human lung mast cells?
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5287-93.
2002: Andrews Allison-Lynn; Holloway John W; Puddicombe Sarah M; Holgate Stephen T; Davies Donna E
Kinetic analysis of the interleukin-13 receptor complex.
The Journal of biological chemistry 2002;277(48):46073-8.
2002: Holgate Stephen T
Airway inflammation and remodeling in asthma: current concepts.
Molecular biotechnology 2002;22(2):179-89.
2002: Brunekreef Bert; Holgate Stephen T
Air pollution and health.
Lancet 2002;360(9341):1233-42.
2002: Howat William J; Barabás Tony; Holmes James A; Holgate Stephen T; Lackie Peter M
Distribution of basement membrane pores in bronchus revealed by microscopy following epithelial removal.
Journal of structural biology 2002;139(3):137-45.
2002: Yuyama Noriko; Davies Donna E; Akaiwa Mina; Matsui Keiko; Hamasaki Yuhei; Suminami Yoshinori; Yoshida Ning Lu; Maeda Miyako; Pandit Anita; Lordan James L; Kamogawa Yumiko; Arima Kazuhiko; Nagumo Fumio; Sugimachi Mitsuhiko; Berger Ann; Richards Ivan; Roberds Steven L; Yamashita Tetsuji; Kishi Fumio; Kato Hiroshi; Arai Ken-ichi; Ohshima Koichi; Tadano Jutaro; Hamasaki Naotaka; Miyatake Shoichiro; Sugita Yuji; Holgate Stephen T; Izuhara Kenji
Analysis of novel disease-related genes in bronchial asthma.
Cytokine 2002;19(6):287-96.
2002: Babu K Suresh; Holgate Stephen T
The role of anti-IgE therapies in the treatment of asthma.
Hospital medicine (London, England : 1998) 2002;63(8):483-6.
2002: Bucchieri Fabio; Puddicombe Sarah M; Lordan James L; Richter Audrey; Buchanan Diane; Wilson Susan J; Ward Jon; Zummo Giovanni; Howarth Peter H; Djukanovic Ratko; Holgate Stephen T; Davies Donna E
Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis.
American journal of respiratory cell and molecular biology 2002;27(2):179-85.
2002: Ritz Stacey A; Stämpfli Martin R; Davies Donna E; Holgate Stephen T; Jordana Manel
On the generation of allergic airway diseases: from GM-CSF to Kyoto.
Trends in immunology 2002;23(8):396-402.
2002: Polosa R; Rorke S; Holgate S T
Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease.
Thorax 2002;57(7):649-54.
2002: Richter Audrey; O'Donnell Rory A; Powell Robert M; Sanders Michael W; Holgate Stephen T; Djukanovic Ratko; Davies Donna E
Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke.
American journal of respiratory cell and molecular biology 2002;27(1):85-90.
2002: Lordan James L; Bucchieri Fabio; Richter Audrey; Konstantinidis Athanassias; Holloway John W; Thornber Matthew; Puddicombe Sarah M; Buchanan Diana; Wilson Susan J; Djukanovic Ratko; Holgate Stephen T; Davies Donna E
Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):407-14.
2002: Xu J; Benyon R C; Leir S-H; Zhang S; Holgate S T; Lackie P M
Matrix metalloproteinase-2 from bronchial epithelial cells induces the proliferation of subepithelial fibroblasts.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(6):881-8.
2002: Brightling Christopher E; Bradding Peter; Symon Fiona A; Holgate Stephen T; Wardlaw Andrew J; Pavord Ian D
Mast-cell infiltration of airway smooth muscle in asthma.
The New England journal of medicine 2002;346(22):1699-705.
2002: Babu K Suresh; Holgate Stephen T
Newer therapies for asthma: a focus on anti-IgE.
The Indian journal of chest diseases & allied sciences 2002;44(2):107-15.
2002: Papadopoulos N G; Stanciu L A; Papi A; Holgate S T; Johnston S L
Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(4):537-42.
2002: Papadopoulos N G; Stanciu L A; Papi A; Holgate S T; Johnston S L
A defective type 1 response to rhinovirus in atopic asthma.
Thorax 2002;57(4):328-32.
2002: Rorke S; Jennison S; Jeffs J A; Sampson A P; Arshad H; Holgate S T
Role of cysteinyl leukotrienes in adenosine 5'-monophosphate induced bronchoconstriction in asthma.
Thorax 2002;57(4):323-7.
2002: Cho S-H; Stanciu L A; Begishivili T; Bates P J; Holgate S T; Johnston S L
Peripheral blood CD4+ and CD8+ T cell type 1 and type 2 cytokine production in atopic asthmatic and normal subjects.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2002;32(3):427-33.
2002: Hansel Trevor T; Sterk Peter J; Holgate Stephen T; Barnes Peter J
The trials and tribulations of anti-IL-5 em leader.
The Journal of allergy and clinical immunology 2002;109(3):575-6.
2002: Corne Jonathan M; Marshall Clare; Smith Sandra; Schreiber Jacquie; Sanderson Gwendolyn; Holgate Stephen T; Johnston Sebastian L
Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study.
Lancet 2002;359(9309):831-4.
2002: Holgate Stephen T; Salvi Sundeep S
Mast cell tryptase as a proinflamatory mediator in late-phase asthmatic response.
Current allergy and asthma reports 2002;2(2):105-6.
2002: Lewith G T; Watkins A D; Hyland M E; Shaw S; Broomfield J A; Dolan G; Holgate S T
Use of ultramolecular potencies of allergen to treat asthmatic people allergic to house dust mite: double blind randomised controlled clinical trial.
BMJ (Clinical research ed.) 2002;324(7336):520.
2002: Holgate Stephen T
Asthma: more than an inflammatory disease.
Current opinion in allergy and clinical immunology 2002;2(1):27-9.
2002: Seymour Michelle L; Gilby Natalie; Bardin Philip G; Fraenkel David J; Sanderson Gwendolyn; Penrose John F; Holgate Stephen T; Johnston Sebastian L; Sampson Anthony P
Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects.
The Journal of infectious diseases 2002;185(4):540-4.
2002: Holgate Stephen T
Adenosine provocation: a new test for allergic type airway inflammation.
American journal of respiratory and critical care medicine 2002;165(3):317-8.
2002: Holgate Stephen T
Adenosine: a key effector molecule of asthma or just another mediator?
American journal of physiology. Lung cellular and molecular physiology 2002;282(2):L167-8.
2002: Polosa Riccardo; Puddicombe Sarah M; Krishna M Thirumala; Tuck Angela B; Howarth Peter H; Holgate Stephen T; Davies Donna E
Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects.
The Journal of allergy and clinical immunology 2002;109(1):75-81.
2002: Rhodes Helen L; Thomas Peter; Sporik Richard; Holgate Stephen T; Cogswell Jeremy J
A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status.
American journal of respiratory and critical care medicine 2002;165(2):176-80.
2002: Dahlén Sven-Erik; Malmström Kerstin; Nizankowska Ewa; Dahlén Barbro; Kuna Piotr; Kowalski Marek; Lumry William R; Picado César; Stevenson Donald D; Bousquet Jean; Pauwels Romain; Holgate Stephen T; Shahane Aditi; Zhang Ji; Reiss Theodore F; Szczeklik Andrew
Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial.
American journal of respiratory and critical care medicine 2002;165(1):9-14.
2002: Howat William J; Holgate Stephen T; Lackie Peter M
TGF-beta isoform release and activation during in vitro bronchial epithelial wound repair.
American journal of physiology. Lung cellular and molecular physiology 2002;282(1):L115-23.
2002: Rorke Steuart; Holgate Stephen T
Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease.
American journal of respiratory medicine : drugs, devices, and other interventions 2002;1(2):99-105.
2002: Lordan James L; Holgate Stephen T
H1-antihistamines in asthma.
Clinical allergy and immunology 2002;17():221-48.
2001: Lordan J L; Davies D E; Wilson S J; Dent G; Corkhill A; Jaffar Z; Roberts K; Djukanovic R; Holgate S T
The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma.
The Journal of allergy and clinical immunology 2001;108(6):976-81.
2001: Seymour M L; Rak S; Aberg D; Riise G C; Penrose J F; Kanaoka Y; Austen K F; Holgate S T; Sampson A P
Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics.
American journal of respiratory and critical care medicine 2001;164(11):2051-6.
2001: Babu K S; Arshad S H; Holgate S T
Anti-IgE treatment: an update.
Allergy 2001;56(12):1121-8.
2001: Babu K S; Arshad S H; Holgate S T
Omalizumab, a novel anti-IgE therapy in allergic disorders.
Expert opinion on biological therapy 2001;1(6):1049-58.
2001: Mullings R E; Wilson S J; Puddicombe S M; Lordan J L; Bucchieri F; Djukanovic R; Howarth P H; Harper S; Holgate S T; Davies D E
Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium.
The Journal of allergy and clinical immunology 2001;108(5):832-8.
2001: Salvi S S; Babu K S; Holgate S T
Is asthma really due to a polarized T cell response toward a helper T cell type 2 phenotype?
American journal of respiratory and critical care medicine 2001;164(8 Pt 1):1343-6.
2001: Arshad S H; Holgate S
The role of IgE in allergen-induced inflammation and the potential for intervention with a humanized monoclonal anti-IgE antibody.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(9):1344-51.
2001: Richter A; Puddicombe S M; Lordan J L; Bucchieri F; Wilson S J; Djukanovic R; Dent G; Holgate S T; Davies D E
The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma.
American journal of respiratory cell and molecular biology 2001;25(3):385-91.
2001: Wilson S J; Wallin A; Della-Cioppa G; Sandström T; Holgate S T
Effects of budesonide and formoterol on NF-kappaB, adhesion molecules, and cytokines in asthma.
American journal of respiratory and critical care medicine 2001;164(6):1047-52.
2001: Papi A; Papadopoulos N G; Stanciu L A; Degitz K; Holgate S T; Johnston S L
Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells.
The Journal of allergy and clinical immunology 2001;108(2):221-8.
2001: Papadopoulos N G; Papi A; Meyer J; Stanciu L A; Salvi S; Holgate S T; Johnston S L
Rhinovirus infection up-regulates eotaxin and eotaxin-2 expression in bronchial epithelial cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2001;31(7):1060-6.
2001: Holloway J A; Holgate S T; Semper A E
Expression of the high-affinity IgE receptor on peripheral blood dendritic cells: differential binding of IgE in atopic asthma.
The Journal of allergy and clinical immunology 2001;107(6):1009-18.
2001: Salvi S S; Krishna M T; Sampson A P; Holgate S T
The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma.
Chest 2001;119(5):1533-46.
2001: Redington A E; Meng Q H; Springall D R; Evans T J; Créminon C; Maclouf J; Holgate S T; Howarth P H; Polak J M
Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment.
Thorax 2001;56(5):351-7.
2001: Anderson D F; Zhang S; Bradding P; McGill J I; Holgate S T; Roche W R
The relative contribution of mast cell subsets to conjunctival TH2-like cytokines.
Investigative ophthalmology & visual science 2001;42(5):995-1001.
2001: Hamilton L M; Davies D E; Wilson S J; Kimber I; Dearman R J; Holgate S T
The bronchial epithelium in asthma--much more than a passive barrier.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 2001;56(1):48-54.
2001: Holloway J W; Lonjou C; Beghé B; Peng Q; Gaunt T R; Gomes I; Hall I P; Dewar J C; Wilkinson J; Thomas N S; Holgate S T; Morton N E
Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families.
Genes and immunity 2001;2(1):20-4.
2001: Redington A E; Roche W R; Madden J; Frew A J; Djukanovic R; Holgate S T; Howarth P H
Basic fibroblast growth factor in asthma: measurement in bronchoalveolar lavage fluid basally and following allergen challenge.
The Journal of allergy and clinical immunology 2001;107(2):384-7.
2001: Howat W J; Holmes J A; Holgate S T; Lackie P M
Basement membrane pores in human bronchial epithelium: a conduit for infiltrating cells?
The American journal of pathology 2001;158(2):673-80.
2001: Holgate S T; Lackie P M; Howarth P H; Roche W R; Puddicombe S M; Richter A; Wilson S J; Holloway J W; Davies D E
Invited lecture: activation of the epithelial mesenchymal trophic unit in the pathogenesis of asthma.
International archives of allergy and immunology 2001;124(1-3):253-8.
2001: Lewith G T; Kenyon J N; Broomfield J; Prescott P; Goddard J; Holgate S T
Is electrodermal testing as effective as skin prick tests for diagnosing allergies? A double blind, randomised block design study.
BMJ (Clinical research ed.) 2001;322(7279):131-4.
2001: Holgate S; Bousquet J; Wenzel S; Fox H; Liu J; Castellsague J
Efficacy of omalizumab, an anti-immunoglobulin E antibody, in patients with allergic asthma at high risk of serious asthma-related morbidity and mortality.
Current medical research and opinion 2001;17(4):233-40.
2000: Bryan S A; O'Connor B J; Matti S; Leckie M J; Kanabar V; Khan J; Warrington S J; Renzetti L; Rames A; Bock J A; Boyce M J; Hansel T T; Holgate S T; Barnes P J
Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
Lancet 2000;356(9248):2149-53.
2000: Leckie M J; ten Brinke A; Khan J; Diamant Z; O'Connor B J; Walls C M; Mathur A K; Cowley H C; Chung K F; Djukanovic R; Hansel T T; Holgate S T; Sterk P J; Barnes P J
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.
Lancet 2000;356(9248):2144-8.
2000: Redington A E; Wilson J W; Walls A F; Madden J; Djukanovic R; Holgate S T; Howarth P H
Persistent airway T-lymphocyte activation in chronic corticosteroid-treated symptomatic asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2000;85(6 Pt 1):501-7.
2000: Jesenik F; Springall D R; Redington A E; Doré C J; Abrams D C; Holgate S T; Howarth P H; Polak J M
Validation of endobronchial biopsy specimens for nerve quantitation by computer-assisted image analysis.
The Journal of pathology 2000;192(4):545-8.
2000: Babu K S; Holgate S T
Potential and novel therapies for asthma.
The Journal of the Association of Physicians of India 2000;48(11):1096-102.
2000: Bardin P G; Fraenkel D J; Sanderson G; van Schalkwyk E M; Holgate S T; Johnston S L
Peak expiratory flow changes during experimental rhinovirus infection.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;16(5):980-5.
2000: Bacon A S; Ahluwalia P; Irani A M; Schwartz L B; Holgate S T; Church M K; McGill J I
Tear and conjunctival changes during the allergen-induced early- and late-phase responses.
The Journal of allergy and clinical immunology 2000;106(5):948-54.
2000: Salvi S S; Babu K S; Holgate S T
Glucocorticoids enhance IgE synthesis. Are we heading towards new paradigms?
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(11):1499-505.
2000: Linaker C H; Coggon D; Holgate S T; Clough J; Josephs L; Chauhan A J; Inskip H M
Personal exposure to nitrogen dioxide and risk of airflow obstruction in asthmatic children with upper respiratory infection.
Thorax 2000;55(11):930-3.
2000: Simon Thomas N; Wilkinson J; Lonjou C; Morton N E; Holgate S T
Linkage analysis of markers on chromosome 11q13 with asthma and atopy in a United Kingdom population.
American journal of respiratory and critical care medicine 2000;162(4 Pt 1):1268-72.
2000: Wright S M; Hockey P M; Enhorning G; Strong P; Reid K B; Holgate S T; Djukanovic R; Postle A D
Altered airway surfactant phospholipid composition and reduced lung function in asthma.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(4):1283-92.
2000: Sampson A P; Siddiqui S; Buchanan D; Howarth P H; Holgate S T; Holloway J W; Sayers I
Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast.
Thorax 2000;55 Suppl 2():S28-31.
2000: Holgate S T
Inflammatory and structural changes in the airways of patients with asthma.
Respiratory medicine 2000;94 Suppl D():S3-6.
2000: Holgate S T; Lackie P; Wilson S; Roche W; Davies D
Bronchial epithelium as a key regulator of airway allergen sensitization and remodeling in asthma.
American journal of respiratory and critical care medicine 2000;162(3 Pt 2):S113-7.
2000: Compton S J; Cairns J A; Holgate S T; Walls A F
Human mast cell tryptase stimulates the release of an IL-8-dependent neutrophil chemotactic activity from human umbilical vein endothelial cells (HUVEC).
Clinical and experimental immunology 2000;121(1):31-6.
2000: Puddicombe S M; Polosa R; Richter A; Krishna M T; Howarth P H; Holgate S T; Davies D E
Involvement of the epidermal growth factor receptor in epithelial repair in asthma.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(10):1362-74.
2000: Linaker C H; Chauhan A J; Inskip H M; Holgate S T; Coggon D
Personal exposures of children to nitrogen dioxide relative to concentrations in outdoor air.
Occupational and environmental medicine 2000;57(7):472-6.
2000: Vrugt B; Wilson S; Bron A; Holgate S T; Djukanovic R; Aalbers R
Bronchial angiogenesis in severe glucocorticoid-dependent asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(6):1014-21.
2000: Holgate S T
Epithelial damage and response.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30 Suppl 1():37-41.
2000: Holgate S T
The role of mast cells and basophils in inflammation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30 Suppl 1():28-32.
2000: Papadopoulos N G; Bates P J; Bardin P G; Papi A; Leir S H; Fraenkel D J; Meyer J; Lackie P M; Sanderson G; Holgate S T; Johnston S L
Rhinoviruses infect the lower airways.
The Journal of infectious diseases 2000;181(6):1875-84.
2000: Leir S H; Baker J E; Holgate S T; Lackie P M
Increased CD44 expression in human bronchial epithelial repair after damage or plating at low cell densities.
American journal of physiology. Lung cellular and molecular physiology 2000;278(6):L1129-37.
2000: Papi A; Stanciu L A; Papadopoulos N G; Teran L M; Holgate S T; Johnston S L
Rhinovirus infection induces major histocompatibility complex class I and costimulatory molecule upregulation on respiratory epithelial cells.
The Journal of infectious diseases 2000;181(5):1780-4.
2000: Holgate S T; Arshad H; Stryszak P; Harrison J E
Mometasone furoate antagonizes AMP-induced bronchoconstriction in patients with mild asthma.
The Journal of allergy and clinical immunology 2000;105(5):906-11.
2000: Withers N J; Low J L; Holgate S T; Clough J B
Smoking habits in a cohort of U.K. adolescents.
Respiratory medicine 2000;94(4):391-6.
2000: Wilson S J; Shute J K; Holgate S T; Howarth P H; Bradding P
Localization of interleukin (IL) -4 but not IL-5 to human mast cell secretory granules by immunoelectron microscopy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000;30(4):493-500.
2000: Vrugt B; Wilson S; Bron A; Shute J; Holgate S T; Djukanovic R; Aalbers R
Low-dose methotrexate treatment in severe glucocorticoid-dependent asthma: effect on mucosal inflammation and in vitro sensitivity to glucocorticoids of mitogen-induced T-cell proliferation.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(3):478-85.
2000: Newson E J; Krishna M T; Lau L C; Howarth P H; Holgate S T; Frew A J
Effects of short-term exposure to 0.2 ppm ozone on biomarkers of inflammation in sputum, exhaled nitric oxide, and lung function in subjects with mild atopic asthma.
Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 2000;42(3):270-7.
2000: Thomas N S; Wilkinson J; Lio P; Doull I; Morton N E; Holgate S T
[Genetic factors involved in asthma and atopy. Studies in British families]
Revue des maladies respiratoires 2000;17(1 Pt 2):177-82.
2000: Hidi R; Timmermans S; Liu E; Schudt C; Dent G; Holgate S T; Djukanovic R
Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;15(2):342-9.
2000: Holgate S T; Sampson A P
Antileukotriene therapy. Future directions.
American journal of respiratory and critical care medicine 2000;161(2 Pt 2):S147-53.
2000: Salvi S S; Nordenhall C; Blomberg A; Rudell B; Pourazar J; Kelly F J; Wilson S; Sandström T; Holgate S T; Frew A J
Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):550-7.
2000: Papi A; Papadopoulos N G; Degitz K; Holgate S T; Johnston S L
Corticosteroids inhibit rhinovirus-induced intercellular adhesion molecule-1 up-regulation and promoter activation on respiratory epithelial cells.
The Journal of allergy and clinical immunology 2000;105(2 Pt 1):318-26.
2000: Holgate S T; Davies D E; Lackie P M; Wilson S J; Puddicombe S M; Lordan J L
Epithelial-mesenchymal interactions in the pathogenesis of asthma.
The Journal of allergy and clinical immunology 2000;105(2 Pt 1):193-204.
2000: Holgate S T
Science, medicine, and the future. Allergic disorders.
BMJ (Clinical research ed.) 2000;320(7229):231-4.
2000: Hidi R; Riches V; Al-Ali M; Cruikshank W W; Center D M; Holgate S T; Djukanovic R
Role of B7-CD28/CTLA-4 costimulation and NF-kappa B in allergen-induced T cell chemotaxis by IL-16 and RANTES.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):412-8.
2000: Holgate S T
The bronchial epithelial origins of asthma.
Chemical immunology 2000;78():62-71.
1999: Salvi S; Holgate S T
Could the airway epithelium play an important role in mucosal immunoglobulin A production?
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(12):1597-605.
1999: Holgate S T
Genetic and environmental interaction in allergy and asthma.
The Journal of allergy and clinical immunology 1999;104(6):1139-46.
1999: Jaffar Z H; Stanciu L; Pandit A; Lordan J; Holgate S T; Roberts K
Essential role for both CD80 and CD86 costimulation, but not CD40 interactions, in allergen-induced Th2 cytokine production from asthmatic bronchial tissue: role for alphabeta, but not gammadelta, T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6283-91.
1999: Wilson S J; Leone B A; Anderson D; Manning A; Holgate S T
Immunohistochemical analysis of the activation of NF-kappaB and expression of associated cytokines and adhesion molecules in human models of allergic inflammation.
The Journal of pathology 1999;189(2):265-72.
1999: Bodey K J; Semper A E; Redington A E; Madden J; Teran L M; Holgate S T; Frew A J
Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge.
Allergy 1999;54(10):1083-93.
1999: Pattemore P K; Lampe F C; Smith S; Clough J B; Holgate S T; Johnston S L
Asthma survey items as predictors of respiratory problems in children 2 yrs later: a longitudinal study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(3):650-8.
1999: Salvi S; Holgate S T
Mechanisms of particulate matter toxicity.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(9):1187-94.
1999: Roberts J A; Bradding P; Britten K M; Walls A F; Wilson S; Gratziou C; Holgate S T; Howarth P H
The long-acting beta2-agonist salmeterol xinafoate: effects on airway inflammation in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;14(2):275-82.
1999: Davies D E; Polosa R; Puddicombe S M; Richter A; Holgate S T
The epidermal growth factor receptor and its ligand family: their potential role in repair and remodelling in asthma.
Allergy 1999;54(8):771-83.
1999: Holloway J W; Beghé B; Holgate S T
The genetic basis of atopic asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(8):1023-32.
1999: Mudway I S; Krishna M T; Frew A J; MacLeod D; Sandstrom T; Holgate S T; Kelly F J
Compromised concentrations of ascorbate in fluid lining the respiratory tract in human subjects after exposure to ozone.
Occupational and environmental medicine 1999;56(7):473-81.
1999: Holgate S T
Antihistamines: back to the future. Preface.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29 Suppl 3():iii.
1999: Holgate S T
Experimental models in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29 Suppl 3():82-6.
1999: Teran L M; Carroll M P; Shute J K; Holgate S T
Interleukin 5 release into asthmatic airways 4 and 24 hours after endobronchial allergen challenge: its relationship with eosinophil recruitment.
Cytokine 1999;11(7):518-22.
1999: Cowburn A S; Holgate S T; Sampson A P
IL-5 increases expression of 5-lipoxygenase-activating protein and translocates 5-lipoxygenase to the nucleus in human blood eosinophils.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):456-65.
1999: Blomberg A; Mudway I S; Nordenhäll C; Hedenström H; Kelly F J; Frew A J; Holgate S T; Sandström T
Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;13(6):1418-28.
1999: Vrugt B; Wilson S; Underwood J; Bron A; de Bruyn R; Bradding P; Holgate S T; Djukanovic R; Aalbers R
Mucosal inflammation in severe glucocorticoid-dependent asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;13(6):1245-52.
1999: Holgate S T; Lackie P M; Davies D E; Roche W R; Walls A F
The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29 Suppl 2():90-5.
1999: Lee S C; Jaffar Z H; Wan K S; Holgate S T; Roberts K
Regulation of pulmonary T cell responses to inhaled antigen: role in Th1- and Th2-mediated inflammation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(11):6867-79.
1999: Chung K F; Godard P; Adelroth E; Ayres J; Barnes N; Barnes P; Bel E; Burney P; Chanez P; Connett G; Corrigan C; de Blic J; Fabbri L; Holgate S T; Ind P; Joos G; Kerstjens H; Leuenberger P; Lofdahl C G; McKenzie S; Magnussen H; Postma D; Saetta M; Salmeron S; Sterk P
Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1999;13(5):1198-208.
1999: Salvi S; Semper A; Blomberg A; Holloway J; Jaffar Z; Papi A; Teran L; Polosa R; Kelly F; Sandström T; Holgate S; Frew A
Interleukin-5 production by human airway epithelial cells.
American journal of respiratory cell and molecular biology 1999;20(5):984-91.
1999: Polosa R; Prosperini G; Leir S H; Holgate S T; Lackie P M; Davies D E
Expression of c-erbB receptors and ligands in human bronchial mucosa.
American journal of respiratory cell and molecular biology 1999;20(5):914-23.
1999: Zhang S; Smartt H; Holgate S T; Roche W R
Growth factors secreted by bronchial epithelial cells control myofibroblast proliferation: an in vitro co-culture model of airway remodeling in asthma.
Laboratory investigation; a journal of technical methods and pathology 1999;79(4):395-405.
1999: Gregory A; Doull I; Pearce N; Cheng S; Leadbitter P; Holgate S; Beasley R
The relationship between anthropometric measurements at birth: asthma and atopy in childhood.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(3):330-3.
1999: Salvi S; Blomberg A; Rudell B; Kelly F; Sandström T; Holgate S T; Frew A
Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers.
American journal of respiratory and critical care medicine 1999;159(3):702-9.
1999: Wilkinson J; Thomas N S; Morton N; Holgate S T
Candidate gene and mutational analysis in asthma and atopy.
International archives of allergy and immunology 1999;118(2-4):265-7.
1999: Compton S J; Cairns J A; Holgate S T; Walls A F
Interaction of human mast cell tryptase with endothelial cells to stimulate inflammatory cell recruitment.
International archives of allergy and immunology 1999;118(2-4):204-5.
1999: Makker H K; Springall D R; Redington A E; Ghatei M A; Bloom S R; Polak J M; Howarth P H; Holgate S T
Airway endothelin levels in asthma: influence of endobronchial hypertonic saline challenge.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1999;29(2):241-7.
1999: Blomberg A; Krishna M T; Helleday R; Söderberg M; Ledin M C; Kelly F J; Frew A J; Holgate S T; Sandström T
Persistent airway inflammation but accommodated antioxidant and lung function responses after repeated daily exposure to nitrogen dioxide.
American journal of respiratory and critical care medicine 1999;159(2):536-43.
1999: Davies D E; Djukanovic R; Holgate S T
Application of functional genomics to study of inflammatory airways disease.
Thorax 1999;54(1):79-81.
1999: Wallin A; Sandström T; Söderberg M; Howarth P; Lundbäck B; Della-Cioppa G; Wilson S; Judd M; Djukanovic R; Holgate S; Lindberg A; Larssen L; Melander B
The effects of regular inhaled formoterol, budesonide, and placebo on mucosal inflammation and clinical indices in mild asthma.
American journal of respiratory and critical care medicine 1999;159(1):79-86.
1999: Jaffar Z; Roberts K; Pandit A; Linsley P; Djukanovic R; Holgate S
B7 costimulation is required for IL-5 and IL-13 secretion by bronchial biopsy tissue of atopic asthmatic subjects in response to allergen stimulation.
American journal of respiratory cell and molecular biology 1999;20(1):153-62.
1998: Holgate S T; Mavroleon G
The molecular and cell biology of allergy.
The Journal of laryngology and otology 1998;112(12):1126-37.
1998: Redington A E; Roche W R; Holgate S T; Howarth P H
Co-localization of immunoreactive transforming growth factor-beta 1 and decorin in bronchial biopsies from asthmatic and normal subjects.
The Journal of pathology 1998;186(4):410-5.
1998: Holgate S T
The inflammation-repair cycle in asthma: the pivotal role of the airway epithelium.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28 Suppl 5():97-103.
1998: Wilkinson J; Grimley S; Collins A; Thomas N S; Holgate S T; Morton N
Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores.
Genomics 1998;53(3):251-9.
1998: McGill J I; Holgate S T; Church M K; Anderson D F; Bacon A
Allergic eye disease mechanisms.
The British journal of ophthalmology 1998;82(10):1203-14.
1998: Zhang S; Anderson D F; Bradding P; Coward W R; Baddeley S M; MacLeod J D; McGill J I; Church M K; Holgate S T; Roche W R
Human mast cells express stem cell factor.
The Journal of pathology 1998;186(1):59-66.
1998: Shute J K; Tenor H; Church M K; Holgate S T
Theophylline inhibits the release of eosinophil survival cytokines--is Raf-1 the protein kinase A target?
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28 Suppl 3():47-52.
1998: Fleming J S; Conway J H; Holgate S T; Moore E A; Hashish A H; Bailey A G; Martonen T B
Evaluation of the accuracy and precision of lung aerosol deposition measurements from planar radionuclide imaging using simulation.
Physics in medicine and biology 1998;43(8):2423-9.
1998: Compton S J; Cairns J A; Holgate S T; Walls A F
The role of mast cell tryptase in regulating endothelial cell proliferation, cytokine release, and adhesion molecule expression: tryptase induces expression of mRNA for IL-1 beta and IL-8 and stimulates the selective release of IL-8 from human umbilical vein endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(4):1939-46.
1998: Withers N J; Low L; Holgate S T; Clough J B
The natural history of respiratory symptoms in a cohort of adolescents.
American journal of respiratory and critical care medicine 1998;158(2):352-7.
1998: Krishna M T; Madden J; Teran L M; Biscione G L; Lau L C; Withers N J; Sandström T; Mudway I; Kelly F J; Walls A; Frew A J; Holgate S T
Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;11(6):1294-300.
1998: Hodges E; Dasmahapatra J; Smith J L; Quin C T; Lanham S; Krishna M T; Holgate S T; Frew A J
T cell receptor (TCR) Vbeta gene usage in bronchoalveolar lavage and peripheral blood T cells from asthmatic and normal subjects.
Clinical and experimental immunology 1998;112(3):363-74.
1998: Holgate S T
Biomarkers of asthma.
Lancet 1998;351(9112):1300-1.
1998: Banik A N; Holgate S T
Problems and progress in measuring methacholine bronchial reactivity.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1998;28 Suppl 1():15-9; discussion 32-6.
1998: Bardin P G; Dorward M A; Lampe F C; Franke B; Holgate S T
Effect of selective phosphodiesterase 3 inhibition on the early and late asthmatic responses to inhaled allergen.
British journal of clinical pharmacology 1998;45(4):387-91.
1998: Holgate S T
Asthma and allergy--disorders of civilization?
QJM : monthly journal of the Association of Physicians 1998;91(3):171-84.
1998: Doull I J; Campbell M J; Holgate S T
Duration of growth suppressive effects of regular inhaled corticosteroids.
Archives of disease in childhood 1998;78(2):172-3.
1998: Okayama Y; Kobayashi H; Ashman L K; Dobashi K; Nakazawa T; Holgate S T; Church M K; Mori M
Human lung mast cells are enriched in the capacity to produce granulocyte-macrophage colony-stimulating factor in response to IgE-dependent stimulation.
European journal of immunology 1998;28(2):708-15.
1998: Bacon A S; McGill J I; Anderson D F; Baddeley S; Lightman S L; Holgate S T
Adhesion molecules and relationship to leukocyte levels in allergic eye disease.
Investigative ophthalmology & visual science 1998;39(2):322-30.
1998: Cowburn A S; Sladek K; Soja J; Adamek L; Nizankowska E; Szczeklik A; Lam B K; Penrose J F; Austen F K; Holgate S T; Sampson A P
Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma.
The Journal of clinical investigation 1998;101(4):834-46.
1998: Chauhan A J; Krishna M T; Frew A J; Holgate S T
Exposure to nitrogen dioxide (NO2) and respiratory disease risk.
Reviews on environmental health 1998;13(1-2):73-90.
1998: Krishna M T; Chauhan A J; Frew A J; Holgate S T
Toxicological mechanisms underlying oxidant pollutant-induced airway injury.
Reviews on environmental health 1998;13(1-2):59-71.
1998: Williams C; Crossland L; Finnerty J; Crane J; Holgate S; Pearce N; Beasley R
Case-control study of salmeterol and near-fatal attacks of asthma.
Thorax 1998;53(1):7-13.
1998: Blomberg A; Sainsbury C; Rudell B; Frew A J; Holgate S T; Sandström T; Kelly F J
Nasal cavity lining fluid ascorbic acid concentration increases in healthy human volunteers following short term exposure to diesel exhaust.
Free radical research 1998;28(1):59-67.
1998: Redington A E; Hardinge F M; Madden J; Holgate S T; Howarth P H
Cyclosporin A treatment and airways inflammation in corticosteroid-dependent asthma.
Allergy 1998;53(1):94-8.
1998: Holgate S T; Corne J; Jardieu P; Fick R B; Heusser C H
Treatment of allergic airways disease with anti-IgE.
Allergy 1998;53(45 Suppl):83-8.
1997: Macleod J D; Anderson D F; Baddeley S M; Holgate S T; McGill J I; Roche W R
Immunolocalization of cytokines to mast cells in normal and allergic conjunctiva.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1997;27(11):1328-34.
1997: Holgate S T; Bodey K S; Janezic A; Frew A J; Kaplan A P; Teran L M
Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge.
American journal of respiratory and critical care medicine 1997;156(5):1377-83.
1997: Polosa R; Holgate S T
Adenosine bronchoprovocation: a promising marker of allergic inflammation in asthma?
Thorax 1997;52(10):919-23.
1997: Okayama Y; Kobayashi H; Ashman L K; Holgate S T; Church M K; Mori M
Activation of eosinophils with cytokines produced by lung mast cells.
International archives of allergy and immunology 1997;114 Suppl 1():75-7.
1997: Doull I J; Lampe F C; Smith S; Schreiber J; Freezer N J; Holgate S T
Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school age children: randomised double blind placebo controlled trial.
BMJ (Clinical research ed.) 1997;315(7112):858-62.
1997: Thomas N S; Wilkinson J; Holgate S T
The candidate region approach to the genetics of asthma and allergy.
American journal of respiratory and critical care medicine 1997;156(4 Pt 2):S144-51.
1997: Holgate S T
The cellular and mediator basis of asthma in relation to natural history.
Lancet 1997;350 Suppl 2():SII5-9.
1997: Redington A E; Springall D R; Meng Q H; Tuck A B; Holgate S T; Polak J M; Howarth P H
Immunoreactive endothelin in bronchial biopsy specimens: increased expression in asthma and modulation by corticosteroid therapy.
The Journal of allergy and clinical immunology 1997;100(4):544-52.
1997: Teran L M; Park H S; Djukanovic R; Roberts K; Holgate S
Cultured nasal polyps from nonatopic and atopic patients release RANTES spontaneously and after stimulation with phytohemagglutinin.
The Journal of allergy and clinical immunology 1997;100(4):499-504.
1997: Anderson D F; MacLeod J D; Baddeley S M; Bacon A S; McGill J I; Holgate S T; Roche W R
Seasonal allergic conjunctivitis is accompanied by increased mast cell numbers in the absence of leucocyte infiltration.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1997;27(9):1060-6.
1997: Stanciu L A; Shute J; Promwong C; Holgate S T; Djukanovic R
Increased levels of IL-4 in CD8+ T cells in atopic asthma.
The Journal of allergy and clinical immunology 1997;100(3):373-8.
1997: Krishna M T; Springall D; Meng Q H; Withers N; Macleod D; Biscione G; Frew A; Polak J; Holgate S
Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans.
American journal of respiratory and critical care medicine 1997;156(3 Pt 1):943-50.
1997: Bates P J; Sanderson G; Holgate S T; Johnston S L
A comparison of RT-PCR, in-situ hybridisation and in-situ RT-PCR for the detection of rhinovirus infection in paraffin sections.
Journal of virological methods 1997;67(2):153-60.
1997: Redington A E; Madden J; Frew A J; Djukanovic R; Roche W R; Holgate S T; Howarth P H
Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid.
American journal of respiratory and critical care medicine 1997;156(2 Pt 1):642-7.
1997: Blomberg A; Krishna M T; Bocchino V; Biscione G L; Shute J K; Kelly F J; Frew A J; Holgate S T; Sandström T
The inflammatory effects of 2 ppm NO2 on the airways of healthy subjects.
American journal of respiratory and critical care medicine 1997;156(2 Pt 1):418-24.
1997: Dewar J C; Wilkinson J; Wheatley A; Thomas N S; Doull I; Morton N; Lio P; Harvey J F; Liggett S B; Holgate S T; Hall I P
The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families.
The Journal of allergy and clinical immunology 1997;100(2):261-5.
1997: Vrugt B; Wilson S; van Velzen E; Bron A; Shute J K; Holgate S T; Djukanovic R; Aalbers R
Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients.
Thorax 1997;52(7):662-4.
1997: Thomas N S; Holgate S T
Candidate locus approach for studying the genetics of asthma and atopy.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 1997;52(3):296-302.
1997: Doull l J; Sandall D; Smith S; Schreiber J; Freezer N J; Holgate S T
Differential inhibitory effect of regular inhaled corticosteroid on airway responsiveness to adenosine 5' monophosphate, methacholine, and bradykinin in symptomatic children with recurrent wheeze.
Pediatric pulmonology 1997;23(6):404-11.
1997: Shute J K; Vrugt B; Lindley I J; Holgate S T; Bron A; Aalbers R; Djukanovic R
Free and complexed interleukin-8 in blood and bronchial mucosa in asthma.
American journal of respiratory and critical care medicine 1997;155(6):1877-83.
1997: Dewar J; Wheatley A; Wilkinson J; Holgate S T; Thomas N S; Lio P; Morton N E; Hall I P
Association of the Gln 27 beta 2-adrenoceptor polymorphism and IgE variability in asthmatic families.
Chest 1997;111(6 Suppl):78S-79S.
1997: Redington A E; Springall D R; Ghatei M A; Madden J; Bloom S R; Frew A J; Polak J M; Holgate S T; Howarth P H
Airway endothelin levels in asthma: influence of endobronchial allergen challenge and maintenance corticosteroid therapy.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(5):1026-32.
1997: Krishna M T; Blomberg A; Biscione G L; Kelly F; Sandstrom T; Frew A; Holgate S
Short-term ozone exposure upregulates P-selectin in normal human airways.
American journal of respiratory and critical care medicine 1997;155(5):1798-803.
1997: Shute J K; Parmar J; Holgate S T; Howarth P H
Urinary glycosaminoglycan levels are increased in acute severe asthma--a role for eosinophil-derived gelatinase B?
International archives of allergy and immunology 1997;113(1-3):366-7.
1997: Sampson A P; Cowburn A S; Sladek K; Adamek L; Nizankowska E; Szczeklik A; Lam B K; Penrose J F; Austen K F; Holgate S T
Profound overexpression of leukotriene C4 synthase in bronchial biopsies from aspirin-intolerant asthmatic patients.
International archives of allergy and immunology 1997;113(1-3):355-7.
1997: Corne J M; Holgate S T
Mechanisms of virus induced exacerbations of asthma.
Thorax 1997;52(4):380-9.
1997: Teran L M; Campos M G; Begishvilli B T; Schröder J M; Djukanovic R; Shute J K; Church M K; Holgate S T; Davies D E
Identification of neutrophil chemotactic factors in bronchoalveolar lavage fluid of asthmatic patients.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1997;27(4):396-405.
1997: Teran L M; Johnston S L; Schröder J M; Church M K; Holgate S T
Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma.
American journal of respiratory and critical care medicine 1997;155(4):1362-6.
1997: Sampson A P; Corne J M; Holgate S T
[In Process Citation]
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 1997;7(3):167-74.
1997: Djukanovic R; Homeyard S; Gratziou C; Madden J; Walls A; Montefort S; Peroni D; Polosa R; Holgate S; Howarth P
The effect of treatment with oral corticosteroids on asthma symptoms and airway inflammation.
American journal of respiratory and critical care medicine 1997;155(3):826-32.
1997: Corne J; Djukanovic R; Thomas L; Warner J; Botta L; Grandordy B; Gygax D; Heusser C; Patalano F; Richardson W; Kilchherr E; Staehelin T; Davis F; Gordon W; Sun L; Liou R; Wang G; Chang T W; Holgate S
The effect of intravenous administration of a chimeric anti-IgE antibody on serum IgE levels in atopic subjects: efficacy, safety, and pharmacokinetics.
The Journal of clinical investigation 1997;99(5):879-87.
1997: Griffiths T L; Christie J M; Parsons S T; Holgate S T
The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1997;10(1):156-60.
1997: Lackie P M; Baker J E; Günthert U; Holgate S T
Expression of CD44 isoforms is increased in the airway epithelium of asthmatic subjects.
American journal of respiratory cell and molecular biology 1997;16(1):14-22.
1996: Douglass J; Dhami D; Bulpitt M; Lindley I J; Shute J; Church M K; Holgate S T
Intradermal challenge with interleukin-8 causes tissue oedema and neutrophil accumulation in atopic and non-atopic human subjects.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26(12):1371-9.
1996: Kelly F J; Blomberg A; Frew A; Holgate S T; Sandstrom T
Antioxidant kinetics in lung lavage fluid following exposure of humans to nitrogen dioxide.
American journal of respiratory and critical care medicine 1996;154(6 Pt 1):1700-5.
1996: Bardin P G; Sanderson G; Robinson B S; Holgate S T; Tyrrell D A
Experimental rhinovirus infection in volunteers.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(11):2250-5.
1996: Peroni D G; Djukanovic R; Bradding P; Feather I H; Montefort S; Howarth P H; Jones D B; Holgate S T
Expression of CD44 and integrins in bronchial mucosa of normal and mildly asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(11):2236-42.
1996: Holgate S T
A rationale for the use of nedocromil sodium in the treatment of asthma.
The Journal of allergy and clinical immunology 1996;98(5 Pt 2):S157-60.
1996: Holgate S T
The immunopharmacology of mild asthma.
The Journal of allergy and clinical immunology 1996;98(5 Pt 2):S7-16; discussion S33-40.
1996: Holgate S T
Asthma mechanisms, determinants of severity and treatment. Forward.
The Journal of allergy and clinical immunology 1996;98(5 Pt 2):S1-2.
1996: Holloway J W; Doull I; Begishvili B; Beasley R; Holgate S T; Howell W M
Lack of evidence of a significant association between HLA-DR, DQ and DP genotypes and atopy in families with HDM allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26(10):1142-9.
1996: Bradding P; Holgate S T
The mast cell as a source of cytokines in asthma.
Annals of the New York Academy of Sciences 1996;796():272-81.
1996: Krishna M T; Chauhan A J; Holgate S T
Molecular mediators of asthma: current insights.
Hospital practice (1995) 1996;31(10):115-9, 124, 126 passim.
1996: Johnston S L; Pattemore P K; Sanderson G; Smith S; Campbell M J; Josephs L K; Cunningham A; Robinson B S; Myint S H; Ward M E; Tyrrell D A; Holgate S T
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis.
American journal of respiratory and critical care medicine 1996;154(3 Pt 1):654-60.
1996: Finnerty J P; Lee C; Wilson S; Madden J; Djukanovic R; Holgate S T
Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(8):1672-7.
1996: Holgate S T
The efficacy and therapeutic position of nedocromil sodium.
Respiratory medicine 1996;90(7):391-4.
1996: Holgate S T
Inhaled sodium cromoglycate.
Respiratory medicine 1996;90(7):387-90.
1996: Teran L M; Noso N; Carroll M; Davies D E; Holgate S; Schröder J M
Eosinophil recruitment following allergen challenge is associated with the release of the chemokine RANTES into asthmatic airways.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(4):1806-12.
1996: Teran L M; Carroll M P; Frew A J; Redington A E; Davies D E; Lindley I; Howarth P H; Church M K; Holgate S T
Leukocyte recruitment after local endobronchial allergen challenge in asthma. Relationship to procedure and to airway interleukin-8 release.
American journal of respiratory and critical care medicine 1996;154(2 Pt 1):469-76.
1996: Frew A J; St-Pierre J; Teran L M; Trefilieff A; Madden J; Peroni D; Bodey K M; Walls A F; Howarth P H; Carroll M P; Holgate S T
Cellular and mediator responses twenty-four hours after local endobronchial allergen challenge of asthmatic airways.
The Journal of allergy and clinical immunology 1996;98(1):133-43.
1996: Holgate S T; Bradding P; Sampson A P
Leukotriene antagonists and synthesis inhibitors: new directions in asthma therapy.
The Journal of allergy and clinical immunology 1996;98(1):1-13.
1996: Synek M; Beasley R; Frew A J; Goulding D; Holloway L; Lampe F C; Roche W R; Holgate S T
Cellular infiltration of the airways in asthma of varying severity.
American journal of respiratory and critical care medicine 1996;154(1):224-30.
1996: Holgate S T
The inflammatory basis of asthma and its implications for drug treatment.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26 Suppl 4():1-4.
1996: Tunon-De-Lara J M; Redington A E; Bradding P; Church M K; Hartley J A; Semper A E; Holgate S T
Dendritic cells in normal and asthmatic airways: expression of the alpha subunit of the high affinity immunoglobulin E receptor (Fc epsilon RI -alpha).
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1996;26(6):648-55.
1996: Doull I; Freezer N; Holgate S
Osteocalcin, growth, and inhaled corticosteroids: a prospective study.
Archives of disease in childhood 1996;74(6):497-501.
1996: Doull I J; Williams A A; Freezer N J; Holgate S T
Descriptive study of cough, wheeze and school absence in childhood.
Thorax 1996;51(6):630-1.
1996: Djukanovic R; Feather I; Gratziou C; Walls A; Peroni D; Bradding P; Judd M; Howarth P H; Holgate S T
Effect of natural allergen exposure during the grass pollen season on airways inflammatory cells and asthma symptoms.
Thorax 1996;51(6):575-81.
1996: Fleming J S; Halson P; Conway J; Moore E; Nassim M A; Hashish A H; Bailey A G; Holgate S T; Martonen T B
Three-dimensional description of pulmonary deposition of inhaled aerosol using data from multimodality imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(5):873-7.
1996: Chauhan A J; Krishna M T; Holgate S T
Aetiology of asthma: how public health and molecular medicine work together.
Molecular medicine today 1996;2(5):192-7.
1996: Polosa R; Hasani A; Cacciola R R; Colombrita R; Agnew J E; Clarke S W; Holgate S T
Opposite effects of inhaled bradykinin and [desArg9]-bradykinin on tracheobronchial clearance in normal humans.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo 1996;51(2):112-6.
1996: Krug N; Teran L M; Redington A E; Gratziou C; Montefort S; Polosa R; Brewster H; Howarth P H; Holgate S T; Frew A J; Carroll M P
Safety aspects of local endobronchial allergen challenge in asthmatic patients.
American journal of respiratory and critical care medicine 1996;153(4 Pt 1):1391-7.
1996: Krug N; Madden J; Redington A E; Lackie P; Djukanovic R; Schauer U; Holgate S T; Frew A J; Howarth P H
T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.
American journal of respiratory cell and molecular biology 1996;14(4):319-26.
1996: Summers Q A; Fleming J S; Dai Y; Perring S; Honeywell R; Gough K J; Renwick A G; Clark A R; Nassim M A; Holgate S T
The pulmonary deposition of two aerosol preparations of nedocromil sodium delivered by MDI assessed by single photon emission computed tomography.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 1996;9 Suppl 1():S93-109.
1996: Linaker C H; Chauhan A J; Inskip H; Frew A J; Sillence A; Coggon D; Holgate S T
Distribution and determinants of personal exposure to nitrogen dioxide in school children.
Occupational and environmental medicine 1996;53(3):200-3.
1996: Gratziou C; Carroll M; Montefort S; Teran L; Howarth P H; Holgate S T
Inflammatory and T-cell profile of asthmatic airways 6 hours after local allergen provocation.
American journal of respiratory and critical care medicine 1996;153(2):515-20.
1996: Synek M; Antó J M; Beasley R; Frew A J; Holloway L; Lampe F C; Lloreta J L; Sunyer J; Thornton A; Holgate S T
Immunopathology of fatal soybean dust-induced asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(1):54-7.
1996: Krishna M T; Springall D R; Frew A J; Polak J M; Holgate S T
Mediators of inflammation in response to air pollution: a focus on ozone and nitrogen dioxide.
Journal of the Royal College of Physicians of London 1996;30(1):61-6.
1996: Stanciu L A; Shute J; Holgate S T; Djukanovic R
Production of IL-8 and IL-4 by positively and negatively selected CD4+ and CD8+ human T cells following a four-step cell separation method including magnetic cell sorting (MACS).
Journal of immunological methods 1996;189(1):107-15.
1996: Fleming J S; Hashish A H; Conway J H; Nassim M A; Holgate S T; Halson P; Moore E; Bailey A G; Martonen T B
Assessment of deposition of inhaled aerosol in the respiratory tract of man using three-dimensional multimodality imaging and mathematical modeling.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 1996;9(3):317-27.
1996: Wilkinson J; Holgate S T
Candidate loci and random marker approaches to studying the genetics of asthma.
Monographs in allergy 1996;33():109-24.
1996: Howell W M; Holgate S T
Human leukocyte antigen genes and allergic disease.
Monographs in allergy 1996;33():53-70.
1995: Krishna M T; Mudway I; Kelly F J; Frew A J; Holgate S T
Ozone, airways and allergic airways disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(12):1150-8.
1995: Holgate S T
The genetics of allergy and asthma: concluding comments.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25 Suppl 2():124-5.
1995: Shah A; Church M K; Holgate S T
Tumour necrosis factor alpha: a potential mediator of asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(11):1038-44.
1995: Kelly F J; Mudway I; Krishna M T; Holgate S T
The free radical basis of air pollution: focus on ozone.
Respiratory medicine 1995;89(10):647-56.
1995: Watson M; Lawrence S; Collins A; Beasley R; Doull I; Begishvili B; Lampe F; Holgate S T; Morton N E
Exclusion from proximal 11q of a common gene with megaphenic effect on atopy.
Annals of human genetics 1995;59(Pt 4):403-11.
1995: Rajakulasingam K; Makker H K; Howarth P H; Holgate S T
Cross refractoriness between bradykinin and hypertonic saline challenges in asthma.
The Journal of allergy and clinical immunology 1995;96(4):502-9.
1995: Freezer N J; Croasdell H; Doull I J; Holgate S T
Effect of regular inhaled beclomethasone on exercise and methacholine airway responses in school children with recurrent wheeze.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(9):1488-93.
1995: Howarth P H; Springall D R; Redington A E; Djukanovic R; Holgate S T; Polak J M
Neuropeptide-containing nerves in endobronchial biopsies from asthmatic and nonasthmatic subjects.
American journal of respiratory cell and molecular biology 1995;13(3):288-96.
1995: Jones K P; Mullee M A; Middleton M; Chapman E; Holgate S T
Peak flow based asthma self-management: a randomised controlled study in general practice. British Thoracic Society Research Committee.
Thorax 1995;50(8):851-7.
1995: Okayama Y; Petit-Frére C; Kassel O; Semper A; Quint D; Tunon-de-Lara M J; Bradding P; Holgate S T; Church M K
IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1796-808.
1995: Chanarin N; Corne J; Holgate S T
Asthma: basis and management at different ages.
Respiratory medicine 1995;89(6):409-13.
1995: Bradding P; Okayama Y; Howarth P H; Church M K; Holgate S T
Heterogeneity of human mast cells based on cytokine content.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(1):297-307.
1995: Bradding P; Feather I H; Wilson S; Holgate S T; Howarth P H
Cytokine immunoreactivity in seasonal rhinitis: regulation by a topical corticosteroid.
American journal of respiratory and critical care medicine 1995;151(6):1900-6.
1995: Doull I J; Freezer N J; Holgate S T
Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate.
American journal of respiratory and critical care medicine 1995;151(6):1715-9.
1995: Wood-Baker R; Smith R; Holgate S T
A double-blind, placebo controlled study of the effect of the specific histamine H1-receptor antagonist, terfenadine, in chronic severe asthma.
British journal of clinical pharmacology 1995;39(6):671-5.
1995: Djukanovic R; Finnerty J P; Lee C; Wilson S; Madden J; Holgate S T
The effects of theophylline on mucosal inflammation in asthmatic airways: biopsy results.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(5):831-3.
1995: Howarth P H; Bradding P; Feather I; Wilson S; Church M K; Holgate S T
Mucosal cytokine expression in allergic rhinitis.
International archives of allergy and immunology 1995;107(1-3):390-1.
1995: Djukanovic R; Howarth P; Vrugt B; Wilson S; Semper A; Bradding P; Aalbers R; Holgate S
Determinants of asthma severity.
International archives of allergy and immunology 1995;107(1-3):389.
1995: Frew A J; Teran L M; Madden J; Trefilieff A; St Pierre J; Semper A; Carroll M P; Holgate S T
Cellular changes 24 hours after endobronchial allergen challenge in asthma.
International archives of allergy and immunology 1995;107(1-3):376-7.
1995: Teran L M; Carroll M; Frew A J; Montefort S; Lau L C; Davies D E; Lindley I; Howarth P H; Church M K; Holgate S T
Neutrophil influx and interleukin-8 release after segmental allergen or saline challenge in asthmatics.
International archives of allergy and immunology 1995;107(1-3):374-5.
1995: Walls A F; He S; Teran L M; Buckley M G; Jung K S; Holgate S T; Shute J K; Cairns J A
Granulocyte recruitment by human mast cell tryptase.
International archives of allergy and immunology 1995;107(1-3):372-3.
1995: Shute J K; Lindley I; Peichl P; Holgate S T; Church M K; Djukanovic R
Mucosal IgA is an important moderator of eosinophil responses to tissue-derived chemoattractants.
International archives of allergy and immunology 1995;107(1-3):340-1.
1995: Bardin P G; Fraenkel D J; Sanderson G; Lampe F; Holgate S T
Lower airways inflammatory response during rhinovirus colds.
International archives of allergy and immunology 1995;107(1-3):127-9.
1995: Bradding P; Mediwake R; Feather I H; Madden J; Church M K; Holgate S T; Howarth P H
TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(5):406-15.
1995: Holgate S T; Church M K; Howarth P H; Morton E N; Frew A J; Djukanovic R
Genetic and environmental influences on airway inflammation in asthma.
International archives of allergy and immunology 1995;107(1-3):29-33.
1995: Howarth P H; Redington A E; Springall D R; Martin U; Bloom S R; Polak J M; Holgate S T
Epithelially derived endothelin and nitric oxide in asthma.
International archives of allergy and immunology 1995;107(1-3):228-30.
1995: Okayama Y; Semper A; Holgate S T; Church M K
Multiple cytokine mRNA expression in human mast cells stimulated via Fc epsilon RI.
International archives of allergy and immunology 1995;107(1-3):158-9.
1995: Bradding P; Redington A E; Djukanovic R; Conrad D J; Holgate S T
15-lipoxygenase immunoreactivity in normal and in asthmatic airways.
American journal of respiratory and critical care medicine 1995;151(4):1201-4.
1995: Redington A E; Springall D R; Ghatei M A; Lau L C; Bloom S R; Holgate S T; Polak J M; Howarth P H
Endothelin in bronchoalveolar lavage fluid and its relation to airflow obstruction in asthma.
American journal of respiratory and critical care medicine 1995;151(4):1034-9.
1995: Polosa R; Rajakulasingam K; Prosperini G; Magrì S; Mastruzzo C; Holgate S T
Inhaled loop diuretics and basal airway responsiveness in man: evidence of a role for cyclo-oxygenase products.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1995;8(4):593-9.
1995: Fraenkel D J; Bardin P G; Sanderson G; Lampe F; Johnston S L; Holgate S T
Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects.
American journal of respiratory and critical care medicine 1995;151(3 Pt 1):879-86.
1995: Polosa R; Ng W H; Crimi N; Vancheri C; Holgate S T; Church M K; Mistretta A
Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma.
American journal of respiratory and critical care medicine 1995;151(3 Pt 1):624-9.
1995: Bardin P G; Fraenkel D; Sanderson G; Dorward M; Johnston S; Holgate S
Increased sensitivity to the consequences of rhinoviral infection in atopic subjects.
Chest 1995;107(3 Suppl):157S.
1995: Wood-Baker R; Town G I; Benning B; Holgate S T
The reproducibility and effect on non-specific airway responsiveness of inhaled prostaglandin D2 and leukotriene D4 in asthmatic subjects.
British journal of clinical pharmacology 1995;39(2):119-23.
1995: Baddeley S M; Bacon A S; McGill J I; Lightman S L; Holgate S T; Roche W R
Mast cell distribution and neutral protease expression in acute and chronic allergic conjunctivitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1995;25(1):41-50.
1995: Semper A E; Hartley J A; Tunon-de-Lara J M; Bradding P; Redington A E; Church M K; Holgate S T
Expression of the high affinity receptor for immunoglobulin E (IgE) by dendritic cells in normals and asthmatics.
Advances in experimental medicine and biology 1995;378():135-8.
1995: Redington A E; Polosa R; Walls A F; Howarth P H; Holgate S T
Role of mast cells and basophils in asthma.
Chemical immunology 1995;62():22-59.
1994: Dai Y; Holgate S T; Church M K; Shute J K
Modulation of the chemotactic responsiveness of guinea pig neutrophils to hrIL-8 and fMLP.
Journal of leukocyte biology 1994;56(6):776-83.
1994: Holgate S T; Walters C; Walls A F; Lawrence S; Shell D J; Variend S; Fleming P J; Berry P J; Gilbert R E; Robinson C
The anaphylaxis hypothesis of sudden infant death syndrome (SIDS): mast cell degranulation in cot death revealed by elevated concentrations of tryptase in serum.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1994;24(12):1115-22.
1994: Thomas L H; Fraenkel D J; Bardin P G; Johnston S L; Holgate S T; Warner J A
Leukocyte responses to experimental infection with human rhinovirus.
The Journal of allergy and clinical immunology 1994;94(6 Pt 2):1255-62.
1994: Howarth P H; Bradding P; Montefort S; Peroni D; Djukanovic R; Carroll M P; Holgate S T
Mucosal inflammation and asthma.
American journal of respiratory and critical care medicine 1994;150(5 Pt 2):S18-22.
1994: Fraenkel D J; Bardin P G; Sanderson G; Lampe F; Johnston S L; Holgate S T
Immunohistochemical analysis of nasal biopsies during rhinovirus experimental colds.
American journal of respiratory and critical care medicine 1994;150(4):1130-6.
1994: Douglass J A; Dhami D; Gurr C E; Bulpitt M; Shute J K; Howarth P H; Lindley I J; Church M K; Holgate S T
Influence of interleukin-8 challenge in the nasal mucosa in atopic and nonatopic subjects.
American journal of respiratory and critical care medicine 1994;150(4):1108-13.
1994: Lawrence S; Beasley R; Doull I; Begishvili B; Lampe F; Holgate S T; Morton N E
Genetic analysis of atopy and asthma as quantitative traits and ordered polychotomies.
Annals of human genetics 1994;58(Pt 4):359-68.
1994: Zhang L; Redington A E; Holgate S T
RANTES: a novel mediator of allergic inflammation?
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1994;24(10):899-904.
1994: Jackson L; Ståhl E; Holgate S T
Terbutaline via pressurised metered dose inhaled (P-MDI) and Turbuhaler in highly reactive asthmatic patients.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(9):1598-601.
1994: Makker H K; Holgate S T
Mechanisms of exercise-induced asthma.
European journal of clinical investigation 1994;24(9):571-85.
1994: Polosa R; Rajakulasingam K; Prosperini G; Bellofiore S; Britten S; Milazzo L V; Holgate S T
Effect of inhaled bradykinin on indices of airway responsiveness in asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(8):1490-6.
1994: Clough J B; Holgate S T
Episodes of respiratory morbidity in children with cough and wheeze.
American journal of respiratory and critical care medicine 1994;150(1):48-53.
1994: Bradding P; Roberts J A; Britten K M; Montefort S; Djukanovic R; Mueller R; Heusser C H; Howarth P H; Holgate S T
Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.
American journal of respiratory cell and molecular biology 1994;10(5):471-80.
1994: Bardin P G; Fraenkel D J; Sanderson G; Dorward M; Lau L C; Johnston S L; Holgate S T
Amplified rhinovirus colds in atopic subjects.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1994;24(5):457-64.
1994: Howarth P H; Bradding P; Quint D; Redington A E; Holgate S T
Cytokines and airway inflammation.
Annals of the New York Academy of Sciences 1994;725():69-82.
1994: Rajakulasingam K; Polosa R; Church M K; Howarth P H; Holgate S T
Effect of inhaled frusemide on responses of airways to bradykinin and adenosine 5'-monophosphate in asthma.
Thorax 1994;49(5):485-91.
1994: Montefort S; Lai C K; Kapahi P; Leung J; Lai K N; Chan H S; Haskard D O; Howarth P H; Holgate S T
Circulating adhesion molecules in asthma.
American journal of respiratory and critical care medicine 1994;149(5):1149-52.
1994: Makker H K; Walls A F; Goulding D; Montefort S; Varley J J; Carroll M; Howarth P H; Holgate S T
Airway effects of local challenge with hypertonic saline in exercise-induced asthma.
American journal of respiratory and critical care medicine 1994;149(4 Pt 1):1012-9.
1994: Montefort S; Gratziou C; Goulding D; Polosa R; Haskard D O; Howarth P H; Holgate S T; Carroll M P
Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways.
The Journal of clinical investigation 1994;93(4):1411-21.
1994: Twentyman O P; Holgate S T
Reversibility of the allergen-provoked late asthmatic response by an inhaled beta 2-adrenoceptor agonist.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1994;24(3):245-9.
1994: Bardin P G; Johnston S L; Sanderson G; Robinson B S; Pickett M A; Fraenkel D J; Holgate S T
Detection of rhinovirus infection of the nasal mucosa by oligonucleotide in situ hybridization.
American journal of respiratory cell and molecular biology 1994;10(2):207-13.
1994: Perring S; Summers Q; Fleming J S; Nassim M A; Holgate S T
A new method of quantification of the pulmonary regional distribution of aerosols using combined CT and SPECT and its application to nedocromil sodium administered by metered dose inhaler.
The British journal of radiology 1994;67(793):46-53.
1994: Wilson J W; Djukanovic R; Howarth P H; Holgate S T
Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma.
American journal of respiratory and critical care medicine 1994;149(1):86-90.
1994: Holgate S T
Antihistamines in the treatment of asthma.
Clinical reviews in allergy 1994;12(1):65-78.
1993: Johnston S L; Price J N; Lau L C; Walls A F; Walters C; Feather I H; Holgate S T; Howarth P H
The effect of local hyperthermia on allergen-induced nasal congestion and mediator release.
The Journal of allergy and clinical immunology 1993;92(6):850-6.
1993: Roche W R; Montefort S; Baker J; Holgate S T
Cell adhesion molecules and the bronchial epithelium.
The American review of respiratory disease 1993;148(6 Pt 2):S79-82.
1993: Teran L M; Montefort S; Douglass J; Holgate S T
Neutrophil and eosinophil chemotaxins in asthma.
The Quarterly journal of medicine 1993;86(12):761-9.
1993: Hamid Q; Springall D R; Riveros-Moreno V; Chanez P; Howarth P; Redington A; Bousquet J; Godard P; Holgate S; Polak J M
Induction of nitric oxide synthase in asthma.
Lancet 1993;342(8886-8887):1510-3.
1993: Rajakulasingam K; Gnanakumaran G; Church M K; Howarth P H; Holgate S T
Interactive effect of inhaled bradykinin with histamine and PGD2 in bronchial asthma.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(5):1996-2002.
1993: Bardin P G; Pickett M A; Robinson S B; Sanderson G; Holgate S T; Johnston S L
Comparison of 3' and 5' biotin labelled oligonucleotides for in situ hybridisation.
Histochemistry 1993;100(5):387-92.
1993: Town G I; Phillips G J; Landreau M; Louden J; Holgate S T; Kelly F J
Dexamethasone treatment fails to reduce oxygen-induced lung injury in the preterm guinea pig. Effects on pulmonary inflammation and antioxidant status.
Biochemical pharmacology 1993;46(9):1565-72.
1993: Polosa R; Djukanovic R; Rajakulasingam K; Palermo F; Holgate S T
Skin responses to bradykinin, kallidin, and [desArg9]-bradykinin in nonatopic and atopic volunteers.
The Journal of allergy and clinical immunology 1993;92(5):683-9.
1993: Holgate S T
The 1992 Cournand Lecture. Asthma: past, present and future.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(10):1507-20.
1993: Frew A J; Holgate S T
Clinical pharmacology of asthma. Implications for treatment.
Drugs 1993;46(5):847-62.
1993: Bradding P; Feather I H; Wilson S; Bardin P G; Heusser C H; Holgate S T; Howarth P H
Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(7):3853-65.
1993: Makker H K; Montefort S; Holgate S
Investigative use of fibreoptic bronchoscopy for local airway challenge in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(9):1402-8.
1993: Montefort S; Baker J; Roche W R; Holgate S T
The distribution of adhesive mechanisms in the normal bronchial epithelium.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(9):1257-63.
1993: Wood-Baker R; Finnerty J P; Holgate S T
Plasma and urinary histamine in allergen-induced early and late phase asthmatic responses.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(8):1138-44.
1993: Polosa R; Rajakulasingam K; Prosperini G; Church M K; Holgate S T
Relative potencies and time course of changes in adenosine 5'-monophosphate airway responsiveness with inhaled furosemide and bumetanide in asthma.
The Journal of allergy and clinical immunology 1993;92(2):288-97.
1993: Montefort S; Roche W R; Holgate S T
Bronchial epithelial shedding in asthmatics and non-asthmatics.
Respiratory medicine 1993;87 Suppl B():9-11.
1993: Church M K; Holgate S T
Adenosine-induced bronchoconstriction and its inhibition by nedocromil sodium.
The Journal of allergy and clinical immunology 1993;92(1 Pt 2):190-4.
1993: Church M K; Hutson P A; Holgate S T
Nedocromil sodium blocks the early and late phases of allergen challenge in a guinea pig model of asthma.
The Journal of allergy and clinical immunology 1993;92(1 Pt 2):177-82.
1993: Makker H K; Holgate S T
The contribution of neurogenic reflexes to hypertonic saline-induced bronchoconstriction in asthma.
The Journal of allergy and clinical immunology 1993;92(1 Pt 1):82-8.
1993: Rajakulasingam K; Church M K; Howarth P H; Holgate S T
Factors determining bradykinin bronchial responsiveness and refractoriness in asthma.
The Journal of allergy and clinical immunology 1993;92(1 Pt 1):140-2.
1993: Montefort S; Holgate S T; Howarth P H
Leucocyte-endothelial adhesion molecules and their role in bronchial asthma and allergic rhinitis.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(7):1044-54.
1993: Twentyman O P; Sams V R; Holgate S T
Albuterol and nedocromil sodium affect airway and leukocyte responses to allergen.
The American review of respiratory disease 1993;147(6 Pt 1):1425-30.
1993: Makker H K; Lau L C; Thomson H W; Binks S M; Holgate S T
The protective effect of inhaled leukotriene D4 receptor antagonist ICI 204,219 against exercise-induced asthma.
The American review of respiratory disease 1993;147(6 Pt 1):1413-8.
1993: Twentyman O P; Hood S V; Holgate S T
Does baseline airway caliber affect measurements of airway responsiveness to histamine.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;74(6):3034-9.
1993: Twentyman O P; Ollier S; Holgate S T
The effect of H1-receptor blockade on the development of early- and late-phase bronchoconstriction and increased bronchial responsiveness in allergen-induced asthma.
The Journal of allergy and clinical immunology 1993;91(6):1169-78.
1993: Polosa R; Rajakulasingam K; Prosperini G; Milazzo L V; Santonocito G; Holgate S T
Cross-tachyphylactic airway response to inhaled bradykinin, kallidin and [desArg9]-bradykinin in asthmatic subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1993;6(5):687-93.
1993: Redington A E; Bradding P; Holgate S T
The role of cytokines in the pathogenesis of allergic asthma.
Regional immunology 1993;5(3-4):174-200.
1993: Wood-Baker R; Holgate S T
The comparative actions and adverse effect profile of single doses of H1-receptor antihistamines in the airways and skin of subjects with asthma.
The Journal of allergy and clinical immunology 1993;91(5):1005-14.
1993: Rajakulasingam K; Polosa R; Lau L C; Church M K; Holgate S T; Howarth P H
Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation.
Thorax 1993;48(4):324-9.
1993: Montefort S; Djukanovic R; Holgate S T; Roche W R
Ciliated cell damage in the bronchial epithelium of asthmatics and non-asthmatics.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1993;23(3):185-9.
1993: Makker H K; Holgate S T
Relation of the hypertonic saline responsiveness of the airways to exercise induced asthma symptom severity and to histamine or methacholine reactivity.
Thorax 1993;48(2):142-7.
1993: Holgate S
Mediator and cytokine mechanisms in asthma.
Thorax 1993;48(2):103-9.
1993: Holgate S T; Djukanovic R; Howarth P H; Montefort S; Roche W
The T cell and the airway's fibrotic response in asthma.
Chest 1993;103(2 Suppl):125S-128S.
1993: Johnston S L; Sanderson G; Pattemore P K; Smith S; Bardin P G; Bruce C B; Lambden P R; Tyrrell D A; Holgate S T
Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms.
Journal of clinical microbiology 1993;31(1):111-7.
1993: Town I G; Phillips G J; Murdoch E; Holgate S T; Kelly F J
Temporal association between pulmonary inflammation and antioxidant induction following hyperoxic exposure of the preterm guinea pig.
Free radical research communications 1993;18(4):211-21.
1992: Johnston S L; Bardin P G; Harrison J; Ritter W; Joubert J R; Holgate S T
The effects of an oral thromboxane TP receptor antagonist BAY u 3405, on prostaglandin D2- and histamine-induced bronchoconstriction in asthma, and relationship to plasma drug concentrations.
British journal of clinical pharmacology 1992;34(5):402-8.
1992: Polosa R; Hasani A; Pavia D; Agnew J E; Lai C K; Clarke S W; Holgate S T
Acute effect of inhaled bradykinin on tracheobronchial clearance in normal humans.
Thorax 1992;47(11):952-6.
1992: Johnston S L; Clough J B; Pattemore P K; Smith S; Holgate S T
Longitudinal changes in skin-prick test reactivity over 2 years in a population of schoolchildren with respiratory symptoms.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992;22(10):948-57.
1992: Montefort S; Feather I H; Wilson S J; Haskard D O; Lee T H; Holgate S T; Howarth P H
The expression of leukocyte-endothelial adhesion molecules is increased in perennial allergic rhinitis.
American journal of respiratory cell and molecular biology 1992;7(4):393-8.
1992: Wilkinson J R; Roberts J A; Bradding P; Holgate S T; Howarth P H
Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler.
BMJ (Clinical research ed.) 1992;305(6859):931-2.
1992: Polosa R; Cacciola R R; Holgate S T
[The response of the airways in asthmatic patients to kinin inhalations define a type-B2 receptor profile]
Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna 1992;7(4):220-5.
1992: Polosa R; Pavia D; Hasani A; Prosperini G; Clarke S; Holgate S T
[The modulator effect of bradykinin with respect to tracheobronchial clearance in healthy subjects]
Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna 1992;7(4):215-9.
1992: Dow L; Coggon D; Campbell M J; Osmond C; Holgate S T
The interaction between immunoglobulin E and smoking in airflow obstruction in the elderly.
The American review of respiratory disease 1992;146(2):402-7.
1992: Johnston S L; Perry D; O'Toole S; Summers Q A; Holgate S T
Attenuation of exercise induced asthma by local hyperthermia.
Thorax 1992;47(8):592-7.
1992: Pararajasingam C D; Sittampalam L; Damani P; Pattemore P K; Holgate S T
Comparison of the prevalence of asthma among Asian and European children in Southampton.
Thorax 1992;47(7):529-32.
1992: Montefort S; Roberts J A; Beasley R; Holgate S T; Roche W R
The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects.
Thorax 1992;47(7):499-503.
1992: Rajakulasingam K; Polosa R; Lau L C; Church M K; Holgate S T; Howarth P H
The influence of terfenadine and ipratropium bromide alone and in combination on bradykinin-induced nasal symptoms and plasma protein leakage.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992;22(7):717-23.
1992: Gratziou C; Carroll M; Walls A; Howarth P H; Holgate S T
Early changes in T lymphocytes recovered by bronchoalveolar lavage after local allergen challenge of asthmatic airways.
The American review of respiratory disease 1992;145(6):1259-64.
1992: Montefort S; Herbert C A; Robinson C; Holgate S T
The bronchial epithelium as a target for inflammatory attack in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1992;22(5):511-20.
1992: Djukanovic R; Lai C K; Wilson J W; Britten K M; Wilson S J; Roche W R; Howarth P H; Holgate S T
Bronchial mucosal manifestations of atopy: a comparison of markers of inflammation between atopic asthmatics, atopic nonasthmatics and healthy controls.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(5):538-44.
1992: Clough J B; Williams J D; Holgate S T
Profile of bronchial responsiveness in children with respiratory symptoms.
Archives of disease in childhood 1992;67(5):574-9.
1992: Morland C M; Wilson S J; Holgate S T; Roche W R
Selective eosinophil leukocyte recruitment by transendothelial migration and not by leukocyte-endothelial cell adhesion.
American journal of respiratory cell and molecular biology 1992;6(5):557-66.
1992: Finnerty J P; Wood-Baker R; Thomson H; Holgate S T
Role of leukotrienes in exercise-induced asthma. Inhibitory effect of ICI 204219, a potent leukotriene D4 receptor antagonist.
The American review of respiratory disease 1992;145(4 Pt 1):746-9.
1992: Rajakulasingam K; Polosa R; Lau L C; Church M K; Holgate S T; Howarth P H
Nasal effects of bradykinin and capsaicin: influence on plasma protein leakage and role of sensory neurons.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(4):1418-24.
1992: Summers Q A; Singh S; Honeywell R G; Renwick A G; Holgate S T
The effect of respiratory manoeuvres and pharmacological agents on the pharmacokinetics of nedocromil sodium after inhalation.
British journal of clinical pharmacology 1992;33(4):431-8.
1992: Conway J H; Fleming J S; Perring S; Holgate S T
Humidification as an adjunct to chest physiotherapy in aiding tracheo-bronchial clearance in patients with bronchiectasis.
Respiratory medicine 1992;86(2):109-14.
1992: Richards R; Fowler C; Simpson S; Renwick A G; Holgate S T
Inhaled histamine increases the rate of absorption of sodium cromoglycate from the lung.
British journal of clinical pharmacology 1992;33(3):337-41.
1992: Finnerty J P; Harvey A; Holgate S T
The relative contributions of histamine and prostanoids to bronchoconstriction provoked by isocapnic hyperventilation in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(3):323-30.
1992: Summers Q A; Higgins P G; Barrow I G; Tyrrell D A; Holgate S T
Bronchial reactivity to histamine and bradykinin is unchanged after rhinovirus infection in normal subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(3):313-7.
1992: Bardin P G; Johnston S L; Holgate S T
Anti-inflammatory strategies for the treatment of asthma.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1992;81(6):303-9.
1992: Djukanovic R; Wilson J W; Britten K M; Wilson S J; Walls A F; Roche W R; Howarth P H; Holgate S T
Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma.
The American review of respiratory disease 1992;145(3):669-74.
1992: Rimmer S J; Akerman C L; Hunt T C; Church M K; Holgate S T; Shute J K
Density profile of bronchoalveolar lavage eosinophils in the guinea pig model of allergen-induced late-phase allergic responses.
American journal of respiratory cell and molecular biology 1992;6(3):340-8.
1992: Josephs L K; Gregg I; Mullee M A; Campbell M J; Holgate S T
A longitudinal study of baseline FEV1 and bronchial responsiveness in patients with asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1992;5(1):32-9.
1992: Dow L; Coggon D; Holgate S T
Respiratory symptoms as predictors of airways lability in an elderly population.
Respiratory medicine 1992;86(1):27-32.
1992: Lai C K; Djukanovic R; Wilson J W; Wilson S J; Britten K M; Howarth P H; Holgate S T
Effect of inhaled platelet-activating factor on bronchial inflammation in atopic non-asthmatic subjects.
International archives of allergy and immunology 1992;99(1):84-90.
1991: Twentyman O P; Finnerty J P; Holgate S T
The inhibitory effect of nebulized albuterol on the early and late asthmatic reactions and increase in airway responsiveness provoked by inhaled allergen in asthma.
The American review of respiratory disease 1991;144(4):782-7.
1991: Chidley K E; Wood-Baker R; Town G I; Sleet R A; Holgate S T
Reassessment of asthma management in an accident and emergency department.
Respiratory medicine 1991;85(5):373-7.
1991: Kelly F J; Town G I; Phillips G J; Holgate S T; Roche W R; Postle A D
The pre-term guinea-pig: a model for the study of neonatal lung disease.
Clinical science (London, England : 1979) 1991;81(3):439-46.
1991: Walls A F; Bennett A R; Godfrey R C; Holgate S T; Church M K
Mast cell tryptase and histamine concentrations in bronchoalveolar lavage fluid from patients with interstitial lung disease.
Clinical science (London, England : 1979) 1991;81(2):183-8.
1991: Lai C K; Ollier S; Lau C K; Holgate S T
Effect of azelastine and ketotifen on the bronchial and skin responses to platelet-activating factor in humans.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1991;21(4):489-96.
1991: Rajakulasingam K; Polosa R; Holgate S T; Howarth P H
Comparative nasal effects of bradykinin, kallidin and [Des-Arg9]-bradykinin in atopic rhinitic and normal volunteers.
The Journal of physiology 1991;437():577-87.
1991: Lai C K; Polosa R; Pavia D; Hasani A; Agnew J E; Clarke S W; Holgate S T
Effect of inhaled 15-(s)-hydroxyeicosatetraenoic acid on tracheobronchial clearance in normal human airways.
Thorax 1991;46(6):446-8.
1991: Holgate S T
The mast cell and its function in allergic disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1991;21 Suppl 3():11-6.
1991: Holgate S T
Pharmacological modulation of asthma in relation to mechanisms.
Allergy proceedings : the official journal of regional and state allergy societies 1991;12(3):151-4.
1991: Polosa R; Phillips G D; Rajakulasingam K; Holgate S T
The effect of inhaled ipratropium bromide alone and in combination with oral terfenadine on bronchoconstriction provoked by adenosine 5'-monophosphate and histamine in asthma.
The Journal of allergy and clinical immunology 1991;87(5):939-47.
1991: Djukanovic R; Wilson J W; Lai C K; Holgate S T; Howarth P H
The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma.
The American review of respiratory disease 1991;143(4 Pt 1):772-7.
1991: Clough J B; Williams J D; Holgate S T
Effect of atopy on the natural history of symptoms, peak expiratory flow, and bronchial responsiveness in 7- and 8-year-old children with cough and wheeze. A 12-month longitudinal study [published errarum appears in Am Rev Respir Dis 1992 Aug;146(2):540]
The American review of respiratory disease 1991;143(4 Pt 1):755-60.
1991: Holgate S T; Roche W; Djukanovic R; Wilson J; Britten K; Howarth P
The need for a pathological classification of asthma.
The European respiratory journal. Supplement 1991;13():113s-122s.
1991: Holgate S T; Roche W R; Church M K
The role of the eosinophil in asthma.
The American review of respiratory disease 1991;143(3 Pt 2):S66-70.
1991: Finnerty J P; Twentyman O P; Harris A; Palmer J B; Holgate S T
Effect of GR32191, a potent thromboxane receptor antagonist, on exercise induced bronchoconstriction in asthma.
Thorax 1991;46(3):190-2.
1991: Hunt T C; Campbell A M; Robinson C; Holgate S T
Structural and secretory characteristics of bovine lung and skin mast cells: evidence for the existence of heterogeneity.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1991;21(2):173-82.
1991: Montefort S; Holgate S T
Adhesion molecules and their role in inflammation.
Respiratory medicine 1991;85(2):91-9.
1991: Summers Q A; Nesbit M R; Levin R; Holgate S T
A non-bronchoconstrictor, bacteriostatic preservative for nebuliser solutions.
British journal of clinical pharmacology 1991;31(2):204-6.
1991: Parsons S T; Griffiths T L; Christie J M; Holgate S T
Effect of theophylline and dipyridamole on the respiratory response to isocapnic hypoxia in normal human subjects.
Clinical science (London, England : 1979) 1991;80(2):107-12.
1991: Kelly F J; Rickett G M; Hunt A N; Town G I; Holgate S T; Postle T D
Biochemical maturation of the guinea pig lung and survival following premature delivery.
The International journal of biochemistry 1991;23(4):467-71.
1991: Holgate S T; Church M K; Polosa R
Adenosine: a positive modulator of airway inflammation in asthma.
Annals of the New York Academy of Sciences 1991;629():227-36.
1991: Howarth P H; Wilson J; Djukanovic R; Wilson S; Britten K; Walls A; Roche W R; Holgate S T
Airway inflammation and atopic asthma: a comparative bronchoscopic investigation.
International archives of allergy and applied immunology 1991;94(1-4):266-9.
1991: Holgate S T; Djukanovic R; Wilson J; Roche W; Britten K; Howarth P H
Allergic inflammation and its pharmacological modulation in asthma.
International archives of allergy and applied immunology 1991;94(1-4):210-7.
1991: Walls A F; Rhee Y K; Gould D J; Walters C; Robinson C; Church M K; Holgate S T
Inflammatory mediators and cellular infiltration of the lungs in a guinea pig model of the late asthmatic reaction.
Lung 1991;169(4):227-40.
1991: Howarth P H; Djukanovic R; Wilson J W; Holgate S T; Springall D R; Polak J M
Mucosal nerves in endobronchial biopsies in asthma and non-asthma.
International archives of allergy and applied immunology 1991;94(1-4):330-3.
1990: Town G I; Holgate S T
Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma.
The Journal of allergy and clinical immunology 1990;86(6 Pt 1):886-93.
1990: Twentyman O P; Finnerty J P; Harris A; Palmer J; Holgate S T
Protection against allergen-induced asthma by salmeterol.
Lancet 1990;336(8727):1338-42.
1990: Shute J K; Rimmer S J; Akerman C L; Church M K; Holgate S T
Studies of cellular mechanisms for the generation of superoxide by guinea-pig eosinophils and its dissociation from granule peroxidase release.
Biochemical pharmacology 1990;40(9):2013-21.
1990: Walls A F; Jones D B; Williams J H; Church M K; Holgate S T
Immunohistochemical identification of mast cells in formaldehyde-fixed tissue using monoclonal antibodies specific for tryptase.
The Journal of pathology 1990;162(2):119-26.
1990: Djukanovic R; Wilson J W; Britten K M; Wilson S J; Walls A F; Roche W R; Howarth P H; Holgate S T
Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry.
The American review of respiratory disease 1990;142(4):863-71.
1990: Walls A F; Bennett A R; McBride H M; Glennie M J; Holgate S T; Church M K
Production and characterization of monoclonal antibodies specific for human mast cell tryptase.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1990;20(5):581-9.
1990: Finnerty J P; Polosa R; Holgate S T
Repeated exposure of asthmatic airways to inhaled adenosine 5'-monophosphate attenuates bronchoconstriction provoked by exercise.
The Journal of allergy and clinical immunology 1990;86(3 Pt 1):353-9.
1990: Polosa R; Finnerty J P; Holgate S T
Tachyphylaxis to inhaled histamine in asthma: its significance and relationship to basal airway responsiveness.
The Journal of allergy and clinical immunology 1990;86(2):265-71.
1990: Rafferty P; Jackson L; Smith R; Holgate S T
Terfenadine, a potent histamine H1-receptor antagonist in the treatment of grass pollen sensitive asthma.
British journal of clinical pharmacology 1990;30(2):229-35.
1990: Polosa R; Lau L C; Holgate S T
Inhibition of adenosine 5'-monophosphate- and methacholine-induced bronchoconstriction in asthma by inhaled frusemide.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1990;3(6):665-72.
1990: Lai C K; Polosa R; Holgate S T
Effect of 15-(s)-hydroxyeicosatetraenoic acid on allergen-induced asthmatic responses.
The American review of respiratory disease 1990;141(6):1423-7.
1990: Featherstone R L; Robinson C; Holgate S T; Church M K
Evidence for thromboxane receptor mediated contraction of guinea-pig and human airways in vitro by prostaglandin (PG) D2, 9 alpha,11 beta-PGF2 and PGF2 alpha.
Naunyn-Schmiedeberg's archives of pharmacology 1990;341(5):439-43.
1990: Finnerty J P; Holgate S T
Evidence for the roles of histamine and prostaglandins as mediators in exercise-induced asthma: the inhibitory effect of terfenadine and flurbiprofen alone and in combination.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1990;3(5):540-7.
1990: Hamid M; Rafferty P; Holgate S T
The inhibitory effect of terfenadine and flurbiprofen on early and late-phase bronchoconstriction following allergen challenge in atopic asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1990;20(3):261-7.
1990: Polosa R; Finnerty J P; Holgate S T
Lack of tachyphylaxis to histamine in both moderate and mild asthmatic subjects.
Agents and actions 1990;30(1-2):281-3.
1990: Phillips G D; Finnerty J P; Holgate S T
Comparative protective effect of the inhaled beta 2-agonist salbutamol (albuterol) on bronchoconstriction provoked by histamine, methacholine, and adenosine 5'-monophosphate in asthma.
The Journal of allergy and clinical immunology 1990;85(4):755-62.
1990: Wood-Baker R; Holgate S T
Dose-response relationship of the H1-histamine antagonist, ebastine, against histamine and methacholine-induced bronchoconstriction in patients with asthma.
Agents and actions 1990;30(1-2):284-6.
1990: Polosa R; Phillips G D; Lai C K; Holgate S T
Contribution of histamine and prostanoids to bronchoconstriction provoked by inhaled bradykinin in atopic asthma.
Allergy 1990;45(3):174-82.
1990: Hutson P A; Varley J G; Sanjar S; Kings M; Holgate S T; Church M K
Evidence that neutrophils do not participate in the late-phase airway response provoked by ovalbumin inhalation in conscious, sensitized guinea pigs.
The American review of respiratory disease 1990;141(3):535-9.
1990: Lai C K; Jenkins J R; Polosa R; Holgate S T
Inhaled PAF fails to induce airway hyperresponsiveness to methacholine in normal human subjects.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(3):919-26.
1990: Josephs L K; Gregg I; Holgate S T
Does non-specific bronchial responsiveness indicate the severity of asthma?
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1990;3(2):220-7.
1990: Phillips G D; Ng W H; Church M K; Holgate S T
The response of plasma histamine to bronchoprovocation with methacholine, adenosine 5'-monophosphate, and allergen in atopic nonasthmatic subjects.
The American review of respiratory disease 1990;141(1):9-13.
1990: Lai C K; Phillips G D; Jenkins J R; Holgate S T
The effect of inhaled 15-(s)-hydroxyeicosatetraenoic acid (15-HETE) on airway calibre and non-specific responsiveness in normal and asthmatic human subjects.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1990;3(1):38-45.
1990: Holgate S T; Finnerty J P; Polosa R
Mechanisms of purine-induced bronchoconstriction in asthma.
Archives internationales de pharmacodynamie et de thérapie 1990;303():122-31.
1990: Griffiths T L; Warren S J; Chant A D; Holgate S T
Ventilatory effects of hypoxia and adenosine infusion in patients after bilateral carotid endarterectomy.
Clinical science (London, England : 1979) 1990;78(1):25-31.
1990: Finnerty J P; Holgate S T; Rihoux J P
The effect of 2 weeks treatment with cetirizine on bronchial reactivity to methacholine in asthma.
British journal of clinical pharmacology 1990;29(1):79-84.
1990: Robinson C; Holgate S T
The role of leukotrienes and prostaglandins in asthma: evidence from clinical investigations.
Advances in prostaglandin, thromboxane, and leukotriene research 1990;20():209-16.
1990: Summers Q A; Honeywell R; Renwick A G; Holgate S T
The protective efficacy of inhaled, oral and intravenous nedocromil sodium against adenosine-5'-monophosphate-induced bronchoconstriction in asthmatic volunteers.
Pulmonary pharmacology 1990;3(4):190-7.
1990: Walls A F; Roberts J A; Godfrey R C; Church M K; Holgate S T
Histochemical heterogeneity of human mast cells: disease-related differences in mast cell subsets recovered by bronchoalveolar lavage.
International archives of allergy and applied immunology 1990;92(3):233-41.
1989: Stone J; Hinks L J; Beasley R; Holgate S T; Clayton B A
Reduced selenium status of patients with asthma.
Clinical science (London, England : 1979) 1989;77(5):495-500.
1989: Rafferty P; Ng W H; Phillips G; Clough J; Church M K; Aurich R; Ollier S; Holgate S T
The inhibitory actions of azelastine hydrochloride on the early and late bronchoconstrictor responses to inhaled allergen in atopic asthma.
The Journal of allergy and clinical immunology 1989;84(5 Pt 1):649-57.
1989: Robinson C; Herbert C A; Bedwell S; Shell D J; Holgate S T
The metabolism of prostaglandin D2. Evidence for the sequential conversion by NADPH and NAD+ dependent pathways.
Biochemical pharmacology 1989;38(19):3267-71.
1989: Lai C K; Twentyman O P; Holgate S T
The effect of an increase in inhaled allergen dose after rimiterol hydrobromide on the occurrence and magnitude of the late asthmatic response and the associated change in nonspecific bronchial responsiveness.
The American review of respiratory disease 1989;140(4):917-23.
1989: Finnerty J P; Wilmot C; Holgate S T
Inhibition of hypertonic saline-induced bronchoconstriction by terfenadine and flurbiprofen. Evidence for the predominant role of histamine.
The American review of respiratory disease 1989;140(3):593-7.
1989: Djukanovic R; Finnerty J P; Holgate S T
Wheal-and-flare responses to intradermally injected adenosine 5'-monophosphate, hypertonic saline, and histamine: comparison of atopic and nonatopic subjects.
The Journal of allergy and clinical immunology 1989;84(3):373-8.
1989: Robinson C; Benyon C; Holgate S T; Church M K
The IgE- and calcium-dependent release of eicosanoids and histamine from human purified cutaneous mast cells.
The Journal of investigative dermatology 1989;93(3):397-404.
1989: Clifford R D; Radford M; Howell J B; Holgate S T
Prevalence of respiratory symptoms among 7 and 11 year old schoolchildren and association with asthma.
Archives of disease in childhood 1989;64(8):1118-25.
1989: Phillips G D; Bagga P K; Djukanovic R; Holgate S T
The influence of refractoriness to adenosine 5'-monophosphate on allergen-provoked bronchoconstriction in asthma.
The American review of respiratory disease 1989;140(2):321-6.
1989: Clifford R D; Howell J B; Radford M; Holgate S T
Associations between respiratory symptoms, bronchial response to methacholine, and atopy in two age groups of schoolchildren.
Archives of disease in childhood 1989;64(8):1133-9.
1989: Clifford R D; Radford M; Howell J B; Holgate S T
Prevalence of atopy and range of bronchial response to methacholine in 7 and 11 year old schoolchildren.
Archives of disease in childhood 1989;64(8):1126-32.
1989: Josephs L K; Gregg I; Mullee M A; Holgate S T
Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma. A longitudinal study.
The American review of respiratory disease 1989;140(2):350-7.
1989: Phillips G D; Foord R; Holgate S T
Inhaled lysine-aspirin as a bronchoprovocation procedure in aspirin-sensitive asthma: its repeatability, absence of a late-phase reaction, and the role of histamine.
The Journal of allergy and clinical immunology 1989;84(2):232-41.
1989: Rafferty P; Holgate S T
Histamine and its antagonists in asthma.
The Journal of allergy and clinical immunology 1989;84(2):144-51.
1989: Phillips G D; Polosa R; Holgate S T
The effect of histamine-H1 receptor antagonism with terfenadine on concentration-related AMP-induced bronchoconstriction in asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1989;19(4):405-9.
1989: Lai C K; Gregory J; Holgate S T
Effect of an inhaled mast cell stabiliser, N-acetyl-aspartyl-glutamate (Zy15109) on allergen-induced immediate bronchoconstriction.
British journal of clinical pharmacology 1989;27(5):626-8.
1989: Rafferty P; Holgate S T
The inhibitory effect of azelastine hydrochloride on histamine- and allergen-induced bronchoconstriction in atopic asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1989;19(3):315-20.
1989: Richards R; Phillips G D; Holgate S T
Nedocromil sodium is more potent than sodium cromoglycate against AMP-induced bronchoconstriction in atopic asthmatic subjects.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1989;19(3):285-91.
1989: Holgate S T
Reflections on the mechanism(s) of action of sodium cromoglycate (Intal) and the role of mast cells in asthma.
Respiratory medicine 1989;83 Suppl A():25-31.
1989: Beasley R C; Featherstone R L; Church M K; Rafferty P; Varley J G; Harris A; Robinson C; Holgate S T
Effect of a thromboxane receptor antagonist on PGD2- and allergen-induced bronchoconstriction.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(4):1685-93.
1989: Beasley R; Cushley M; Holgate S T
A self management plan in the treatment of adult asthma.
Thorax 1989;44(3):200-4.
1989: Lai C K; Beasley R; Holgate S T
The effect of an increase in inhaled allergen dose after terfenadine on the occurrence and magnitude of the late asthmatic response.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1989;19(2):209-16.
1989: Phillips G D; Scott V L; Richards R; Holgate S T
Effect of nedocromil sodium and sodium cromoglycate against bronchoconstriction induced by inhaled adenosine 5'-monophosphate.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1989;2(3):210-7.
1989: Roche W R; Beasley R; Williams J H; Holgate S T
Subepithelial fibrosis in the bronchi of asthmatics.
Lancet 1989;1(8637):520-4.
1989: Holgate S T; Finnerty J P
Antihistamines in asthma.
The Journal of allergy and clinical immunology 1989;83(2 Pt 2):537-47.
1989: Phillips G D; Holgate S T
The effect of oral terfenadine alone and in combination with flurbiprofen on the bronchoconstrictor response to inhaled adenosine 5'-monophosphate in nonatopic asthma.
The American review of respiratory disease 1989;139(2):463-9.
1989: Phillips G D; Holgate S T
Interaction of inhaled LTC4 with histamine and PGD2 on airway caliber in asthma.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(1):304-12.
1989: Daxun Z; Rafferty P; Richards R; Summerell S; Holgate S T
Airway refractoriness to adenosine 5'-monophosphate after repeated inhalation.
The Journal of allergy and clinical immunology 1989;83(1):152-8.
1989: Church M K; Benyon R C; Lowman M A; Hutson P A; Holgate S T
Allergy or inflammation? From neuropeptide stimulation of human skin mast cells to studies on the mechanism of the late asthmatic response.
Agents and actions 1989;26(1-2):22-30.
1989: Finnerty J P; Summerell S; Holgate S T
Relationship between skin-prick tests, the multiple allergosorbent test and symptoms of allergic disease.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 1989;19(1):51-6.
1989: Holgate S T; Benyon R C; Lowman M A; Church M K
Activation of human mast cells after immunoglobulin E-dependent and neuropeptide stimulation.
Progress in clinical and biological research 1989;297():103-12; discussion 112-3.
1989: Clough J B; Holgate S T
The natural history of bronchial hyperresponsiveness.
Clinical reviews in allergy 1989;7(3):257-78.
1989: Beasley R; Roche W; Holgate S T
Inflammatory processes in bronchial asthma.
Drugs 1989;37 Suppl 1():117-22; discussion 127-36.
1989: Clarke H; Cushley M J; Persson C G; Holgate S T
The protective effects of intravenous theophylline and enprofylline against histamine- and adenosine 5'-monophosphate-provoked bronchoconstriction: implications for the mechanisms of action of xanthine derivatives in asthma.
Pulmonary pharmacology 1989;2(3):147-54.
1989: Church M K; Hutson P A; Holgate S T
Effect of nedocromil sodium on early and late phase responses to allergen challenge in the guinea-pig.
Drugs 1989;37 Suppl 1():101-8; discussion 127-36.
1989: Polosa R; Holgate S T; Church M K
Adenosine as a pro-inflammatory mediator in asthma.
Pulmonary pharmacology 1989;2(1):21-6.
1989: Johnston S L; Holgate S T
Cellular and chemical mediators--their roles in allergic diseases.
Current opinion in immunology 1989;2(4):513-24.
1989: Church M K; Lowman M A; Robinson C; Holgate S T; Benyon R C
Interaction of neuropeptides with human mast cells.
International archives of allergy and applied immunology 1989;88(1-2):70-8.
1988: Richards R; Simpson S F; Renwick A G; Holgate S T
Inhalation rate of sodium cromoglycate determines plasma pharmacokinetics and protection against AMP-induced bronchoconstriction in asthma.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1988;1(10):896-901.
1988: Rafferty P; Harrison P J; Aurich R; Holgate S T
The in vivo potency and selectivity of azelastine as an H1 histamine-receptor antagonist in human airways and skin.
The Journal of allergy and clinical immunology 1988;82(6):1113-8.
1988: Beasley R; Hovel C; Mani R; Robinson C; Varley J; Holgate S T
Comparative vascular effects of histamine, prostaglandin (PG) D2 and its metabolite 9 alpha,11 beta-PGF2 in human skin.
Clinical allergy 1988;18(6):619-27.
1988: Holgate S T; Jackson L; Watson H K; Ganderton M A
Sensitivity to Parietaria pollen in the Southampton area as determined by skin-prick and RAST tests.
Clinical allergy 1988;18(6):549-56.
1988: Robinson C; Hardy C C; Holgate S T
The metabolism of prostaglandin D2 after inhalation or intravenous infusion in normal men.
Biochimica et biophysica acta 1988;963(2):151-61.
1988: Hutson P A; Holgate S T; Church M K
The effect of cromolyn sodium and albuterol on early and late phase bronchoconstriction and airway leukocyte infiltration after allergen challenge of nonanesthetized guinea pigs.
The American review of respiratory disease 1988;138(5):1157-63.
1988: Featherstone R L; Hutson P A; Holgate S T; Church M K
Active sensitization of guinea-pig airways in vivo enhances in vivo and in vitro responsiveness.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1988;1(9):839-45.
1988: Phillips G D; Holgate S T
Absence of a late-phase response or increase in histamine responsiveness after bronchial provocation with adenosine 5'-monophosphate in atopic and non-atopic asthma.
Clinical science (London, England : 1979) 1988;75(4):429-36.
1988: Miszkiel K A; Beasley R; Holgate S T
The influence of ipratropium bromide and sodium cromoglycate on benzalkonium chloride-induced bronchoconstriction in asthma.
British journal of clinical pharmacology 1988;26(3):295-301.
1988: Phillips G D; Rafferty P; Robinson C; Holgate S T
Dose-related antagonism of leukotriene D4-induced bronchoconstriction by p.o. administration of LY-171883 in nonasthmatic subjects.
The Journal of pharmacology and experimental therapeutics 1988;246(2):732-8.
1988: Richards R; Haas A; Simpson S; Britten A; Renwick A; Holgate S
Effect of methacholine induced bronchoconstriction on the pulmonary distribution and plasma pharmacokinetics of inhaled sodium cromoglycate in subjects with normal and hyperreactive airways.
Thorax 1988;43(8):611-6.
1988: Benyon R C; Church M K; Holgate S T
IgE-dependent activation of human lung mast cells is not associated with increased phospholipid methylation.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(3):954-60.
1988: Rafferty P; Beasley R; Holgate S T
Comparison of the efficacy of preservative free ipratropium bromide and Atrovent nebuliser solution.
Thorax 1988;43(6):446-50.
1988: Hutson P A; Holgate S T; Church M K
Inhibition by nedocromil sodium of early and late phase bronchoconstriction and airway cellular infiltration provoked by ovalbumin inhalation in conscious sensitized guinea-pigs.
British journal of pharmacology 1988;94(1):6-8.
1988: Hardy C C; Bradding P; Robinson C; Holgate S T
Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;64(4):1567-74.
1988: Pomfret S M; Beasley C R; Challenor V; Holgate S T
Relative efficacy of oral verapamil and digoxin alone and in combination for the treatment of patients with chronic atrial fibrillation.
Clinical science (London, England : 1979) 1988;74(4):351-7.
1988: Beasley R; Rafferty P; Holgate S T
Adverse reactions to the non-drug constituents of nebuliser solutions.
British journal of clinical pharmacology 1988;25(3):283-7.
1988: Robinson C; Benyon R C; Agius R M; Jones D B; Wright D H; Holgate S T
The immunoglobulin E- and calcium-dependent release of histamine and eicosanoids from human dispersed mastocytosis spleen cells.
The Journal of investigative dermatology 1988;90(3):359-65.
1988: Miszkiel K A; Beasley R; Rafferty P; Holgate S T
The contribution of histamine release to bronchoconstriction provoked by inhaled benzalkonium chloride in asthma.
British journal of clinical pharmacology 1988;25(2):157-63.
1988: Holgate S T; Finnerty J P
Recent advances in understanding the pathogenesis of asthma and its clinical implications.
The Quarterly journal of medicine 1988;66(249):5-19.
1988: Church M M; Lai C; Beasley R; Featherstone R L; Holgate S T
The mediator and cellular basis of the allergic response.
Allergy 1988;43 Suppl 8():26-9.
1988: Church M K; Holgate S T
Adenosine in asthmatic lung.
Progress in clinical and biological research 1988;263():159-66.
1988: Holgate S T; Robinson C; Church M K
The contribution of mast cell mediators to acute allergic reactions in human skin and airways.
Allergy 1988;43 Suppl 5():22-31.
1987: Holgate S T; Beasley R; Twentyman O P
The pathogenesis and significance of bronchial hyper-responsiveness in airways disease.
Clinical science (London, England : 1979) 1987;73(6):561-72.
1987: Holgate S T; Beasley R C; Robinson C
A search for biochemical markers of human mast cell activation in vivo.
Annals of allergy 1987;59(5 Pt 2):162-5.
1987: Beasley R; Varley J; Robinson C; Holgate S T
Cholinergic-mediated bronchoconstriction induced by prostaglandin D2, its initial metabolite 9 alpha,11 beta-PGF2, and PGF2 alpha in asthma.
The American review of respiratory disease 1987;136(5):1140-4.
1987: Benyon R C; Robinson C; Holgate S T; Church M K
Prostaglandin D2 release from human skin mast cells in response to ionophore A23187.
British journal of pharmacology 1987;92(3):635-8.
1987: Rafferty P; Varley J G; Edwards J S; Holgate S T
Inhibition of exercise-induced asthma by nifedipine: a dose-response study.
British journal of clinical pharmacology 1987;24(4):479-84.
1987: Holgate S T; Mann J S; Church M K; Cushley M J
Mechanisms and significance of adenosine-induced bronchoconstriction in asthma.
Allergy 1987;42(7):481-4.
1987: Hovell C J; Beasley C R; Mani R; Holgate S T
Laser Doppler flowmetry for determining changes in cutaneous blood flow following intradermal injection of histamine.
Clinical allergy 1987;17(5):469-79.
1987: Beasley C R; Robinson C; Featherstone R L; Varley J G; Hardy C C; Church M K; Holgate S T
9 alpha,11 beta-prostaglandin F2, a novel metabolite of prostaglandin D2 is a potent contractile agonist of human and guinea pig airways.
The Journal of clinical investigation 1987;79(3):978-83.
1987: Clifford R D; Pugsley A; Radford M; Holgate S T
Symptoms, atopy, and bronchial response to methacholine in parents with asthma and their children.
Archives of disease in childhood 1987;62(1):66-73.
1987: Robinson C; Beasley C R; Varley J G; Holgate S T
Effects of inhaled 9 alpha, 11 beta-prostaglandin F2 on airway function in man.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():1057-61.
1986: Mann J S; Holgate S T; Renwick A G; Cushley M J
Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma.
Journal of applied physiology (Bethesda, Md. : 1985) 1986;61(5):1667-76.
1986: Hardy C C; Bradding P; Robinson C; Holgate S T
The combined effects of two pairs of mediators, adenosine with methacholine and prostaglandin D2 with histamine, on airway calibre in asthma.
Clinical science (London, England : 1979) 1986;71(4):385-92.
1986: Church M K; Featherstone R L; Cushley M J; Mann J S; Holgate S T
Relationships between adenosine, cyclic nucleotides, and xanthines in asthma.
The Journal of allergy and clinical immunology 1986;78(4 Pt 2):670-5.
1986: Holgate S T; Cushley M J; Mann J S; Hughes P; Church M K
The action of purines on human airways.
Archives internationales de pharmacodynamie et de thérapie 1986;280(2 Suppl):240-52.
1986: Holgate S T; Hardy C; Robinson C; Agius R M; Howarth P H
The mast cell as a primary effector cell in the pathogenesis of asthma.
The Journal of allergy and clinical immunology 1986;77(2):274-82.
1985: Mann J S; Cushley M J; Holgate S T
Adenosine-induced bronchoconstriction in asthma. Role of parasympathetic stimulation and adrenergic inhibition.
The American review of respiratory disease 1985;132(1):1-6.
1985: Holgate S T; Benyon R C; Howarth P H; Agius R; Hardy C; Robinson C; Durham S R; Kay A B; Church M K
Relationship between mediator release from human lung mast cells in vitro and in vivo.
International archives of allergy and applied immunology 1985;77(1-2):47-56.
1984: Holgate S T; Mann J S; Cushley M J
Adenosine as a bronchoconstrictor mediator in asthma and its antagonism by methylxanthines.
The Journal of allergy and clinical immunology 1984;74(3 Pt 1):302-6.

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