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Eric Holland

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Elena Bazzoli; Cameron Brennan; Lisa M DeAngelis; Elena I Fomchenko; Eric C Holland; Jason Huse; Stephen D Nimer; Moritz C Oberstadt; Fabiana Perna; Teodoro Pulvirenti; Nikolaus Schultz; Viviane Tabar; Francesca Voza; Boyoung Wee; Massimo Squatrito
MEF promotes stemness in the pathogenesis of gliomas.
Miriam Benezra; Dolares Hambardzumyan; Eric C Holland; Steven M Larson; Valerie Longo; Tatsuya Ozawa; Oula Penate-Medina; Evan Phillips; Nagavarakishore Pillarsetty; Peter Smith-Jones; Darren R Veach; Pat B Zanzonico; Michelle S Bradbury
Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.
Massimo Squatrito; Fabio Vanoli; Maria Jasin; Nikolaus Schultz; Eric C Holland
53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma.

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2012: Elena Bazzoli; Cameron Brennan; Lisa M DeAngelis; Elena I Fomchenko; Eric C Holland; Jason Huse; Stephen D Nimer; Moritz C Oberstadt; Fabiana Perna; Teodoro Pulvirenti; Nikolaus Schultz; Viviane Tabar; Francesca Voza; Boyoung Wee; Massimo Squatrito
MEF promotes stemness in the pathogenesis of gliomas.
Cell stem cell 2012;11(6):836-44.
2012: Miriam Benezra; Dolares Hambardzumyan; Eric C Holland; Steven M Larson; Valerie Longo; Tatsuya Ozawa; Oula Penate-Medina; Evan Phillips; Nagavarakishore Pillarsetty; Peter Smith-Jones; Darren R Veach; Pat B Zanzonico; Michelle S Bradbury
Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.
Neoplasia (New York, N.Y.) 2012;14(12):1132-43.
2012: Massimo Squatrito; Fabio Vanoli; Maria Jasin; Nikolaus Schultz; Eric C Holland
53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma.
Cancer research 2012;72(20):5250-60.
2012: Joseph D Dougherty; Elena I Fomchenko; Karim Y Helmy; Eric C Holland; Afua A Akuffo; Elena Bazzoli; Cameron Brennan; Eric Schmidt; Ana Milosevic
Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma.
Cancer research 2012;72(18):4856-68.
2012: Nanna Lindberg; Eric C Holland
PDGF in gliomas: more than just a growth factor?
Upsala journal of medical sciences 2012;117(2):92-8.
2012: T S Jones; Eric C Holland
Standard of care therapy for malignant glioma and its effect on tumor and stromal cells.
Oncogene 2012;31(16):1995-2006.
2012: Africa Fernandez-L; Eric C Holland; A Awan; Zaher Nahlé; P Northcott; M Squatrito; Michael D Taylor; Anna Marie Kenney
Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation.
Oncogene 2012;31(15):1923-37.
2012: Nikki A Charles; Richard Gilbertson; Rainer Glass; Eric C Holland; Helmut Kettenmann
The brain tumor microenvironment.
Glia 2012;60(3):502-14.
2012: Nicholas J Szerlip; Mohammad Azim; Debyani Chakravarty; Yuqiang Fang; Eric C Holland; Jason Huse; Suresh Jhanwar; Margaret A Leversha; Jeremy McGuire; Tom Mikkelsen; Tatsuya Ozawa; Alicia Pedraza; Cameron Brennan
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):3041-6.
2012: Lindy E Barrett; Courtney Coker; Zvi Granot; Dolores Hambardzumyan; Eric C Holland; Antonio Iavarone; Hyung-song Nam; Robert Benezra
Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma.
Cancer cell 2012;21(1):11-24.
2012: Karim Helmy; Elena Fomchenko; Christoph Hafemeister; John Halliday; Ken Pitter; Manu Setty; Eric C Holland
Identification of global alteration of translational regulation in glioma in vivo.
PloS one 2012;7(10):e46965.
2012: Manu Setty; Joachim Silber; Frank Neezen; Phaedra Agius; Aaron Arvey; Karim Helmy; Eric C Holland; Jason Huse; Aly A Khan; Christina S Leslie
Inferring transcriptional and microRNA-mediated regulatory programs in glioblastoma.
Molecular systems biology 2012;8():605.
2012: Stefanie Galban; Kevin A Heist; Eric C Holland; Timothy D Johnson; Theodore S Lawrence; Benjamin Lemasson; Judith Leopold; Fei Li; Tom Mikkelsen; Alnawaz Rehemtulla; Thomas L Chenevert; Craig J Galban; Terence M Williams; Brian D Ross
DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma.
PloS one 2012;7(4):e35857.
2012: Joachim Silber; Girish Harinath; Eric C Holland; Anders Jacobsen; Tatsuya Ozawa; Alicia Pedraza; Chris Sander; Jason Huse
miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis.
PloS one 2012;7(3):e33844.
2012: Amanda M Katz; Ken Pitter; Massimo Squatrito; Nduka M Amankulor; Karim Helmy; Eric C Holland
Astrocyte-specific expression patterns associated with the PDGF-induced glioma microenvironment.
PloS one 2012;7(2):e32453.
2011: Terreia S Jones; Eric C Holland
Animal models for glioma drug discovery.
Expert opinion on drug discovery 2011;6(12):1271-83.
2011: Ruimin Huang; Satish K Tickoo; Jelena Vider; Irene Y Cheung; Nai-Kong V Cheung; William L Gerald; Eric C Holland; Ronald Blasberg
MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(12):4138-49.
2011: Fabio M Iwamoto; Maryam Jahdi; Sasan Karimi; Andrew B Lassman; Katherine S Panageas; Elyn Riedel; Lauren E Abrey; Jocelynn Dantis; Lisa M Deangelis; Martin Fleisher; Eric C Holland; Andreas F Hottinger; Adília Hormigo
Longitudinal prospective study of matrix metalloproteinase-9 as a serum marker in gliomas.
Journal of neuro-oncology 2011;105(3):607-12.
2011: Fabio M Iwamoto; Maryam Jahdi; Sasan Karimi; Andrew B Lassman; Katherine S Panageas; Elyn Riedel; Lauren E Abrey; Jocelynn Dantis; Lisa M DeAngelis; Martin Fleisher; Eric C Holland; Andreas F Hottinger; Adília Hormigo
Serum YKL-40 is a marker of prognosis and disease status in high-grade gliomas.
Neuro-oncology 2011;13(11):1244-51.
2011: Clare V Lefave; Ying-Xian Pan; Gina L Rocco; Massimo Squatrito; Sandra Vorlova; Cameron Brennan; Eric C Holland; Luca Cartegni
Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.
The EMBO journal 2011;30(19):4084-97.
2011: Daniel Ciznadija; Eric C Holland; Yuhui Liu; Stephanie M Pyonteck; Andrew Koff
Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma.
Cancer research 2011;71(19):6174-83.
2011: Massimo Squatrito; Eric C Holland
DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance.
Cancer research 2011;71(18):5945-9.
2011: John J Halliday; Eric C Holland
Connective tissue growth factor and the parallels between brain injury and brain tumors.
Journal of the National Cancer Institute 2011;103(15):1141-3.
2011: Nikki A Charles; Eric C Holland; Richard Gilbertson; Rainer Glass; Helmut Kettenmann
The brain tumor microenvironment.
Glia 2011;59(8):1169-80.
2011: Dolares Hambardzumyan; Luis F Parada; Eric C Holland; Al Charest
Genetic modeling of gliomas in mice: new tools to tackle old problems.
Glia 2011;59(8):1155-68.
2011: Andreas F Hottinger; Fabio M Iwamoto; Sasan Karimi; Andrew B Lassman; Katherine S Panageas; Joseph Park; Elyn Riedel; Lauren E Abrey; Jocelynn Dantis; Lisa M DeAngelis; Martin Fleisher; Eric C Holland; Adília Hormigo
YKL-40 and MMP-9 as serum markers for patients with primary central nervous system lymphoma.
Annals of neurology 2011;70(1):163-9.
2011: Christina N Ramirez; Tatsuya Ozawa; Toshimitsu Takagi; Christophe Antczak; David Shum; Robert Graves; Eric C Holland; Hakim Djaballah
Validation of a high-content screening assay using whole-well imaging of transformed phenotypes.
Assay and drug development technologies 2011;9(3):247-61.
2011: Dolares Hambardzumyan; Eric C Holland; Yu-Kang Cheng; Hiroshi Haeno; Franziska Michor
The probable cell of origin of NF1- and PDGF-driven glioblastomas.
PloS one 2011;6(9):e24454.
2011: Boyoung Wee; Nikki Charles; Eric C Holland
Animal models to study cancer-initiating cells from glioblastoma.
Frontiers in bioscience : a journal and virtual library 2011;16():2243-58.
2011: Kenneth L Pitter; Craig J Galban; Stefanie Galbán; Omid Saeed Tehrani; Omid Saeed-Tehrani; Fei Li; Nikki Charles; Michelle S Bradbury; Oren Josh Becher; Thomas L Chenevert; Alnawaz Rehemtulla; Brian D Ross; Eric C Holland; Dolares Hambardzumyan
Perifosine and CCI 779 co-operate to induce cell death and decrease proliferation in PTEN-intact and PTEN-deficient PDGF-driven murine glioblastoma.
PloS one 2011;6(1):e14545.
2010: Massimo Squatrito; Cameron Brennan; Karim Helmy; Jason Huse; John H Petrini; Eric C Holland
Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas.
Cancer cell 2010;18(6):619-29.
2010: Oren Josh Becher; Eric C Holland
Evidence for and against regional differences in neural stem and progenitor cells of the CNS.
Genes & development 2010;24(20):2233-8.
2010: Tatsuya Ozawa; Cameron Brennan; Lu Wang; Massimo Squatrito; Takashi Sasayama; Mitsutoshi Nakada; Jason Huse; Alicia Pedraza; Satoshi Utsuki; Yoshie Yasui; Adesh Tandon; Elena I Fomchenko; Hidehiro Oka; Ross Levine; Kiyotaka Fujii; Marc Ladanyi; Eric C Holland
PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.
Genes & development 2010;24(19):2205-18.
2010: Nikki Charles; Eric C Holland
The perivascular niche microenvironment in brain tumor progression.
Cell cycle (Georgetown, Tex.) 2010;9(15):3012-21.
2010: Jason Huse; Eric C Holland
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.
Nature reviews. Cancer 2010;10(5):319-31.
2010: Angel Ayuso-Sacido; Jennifer A Moliterno; Sebila Kratovac; Gurpreet S Kapoor; Donald M O'Rourke; Eric C Holland; Jose Manuel García-Verdugo; Neeta S Roy; John A Boockvar
Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells.
Journal of neuro-oncology 2010;97(3):323-37.
2010: Wendy L See; Adina R Heinberg; Eric C Holland; Marilyn D Resh
p27 deficiency is associated with migration defects in PDGF-expressing gliomas in vivo.
Cell cycle (Georgetown, Tex.) 2010;9(8):1562-7.
2010: W L See; J P Miller; M Squatrito; Eric C Holland; Marilyn D Resh; Andrew Koff
Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas.
Oncogene 2010;29(12):1720-31.
2010: Oren Josh Becher; Dolares Hambardzumyan; Talia R Walker; Karim Helmy; Javad Nazarian; Steffen Albrecht; Rebecca L Hiner; Sarah Gall; Jason Huse; Nada Jabado; Tobey J MacDonald; Eric C Holland
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma.
Cancer research 2010;70(6):2548-57.
2010: Nikki Charles; Tatsuya Ozawa; Massimo Squatrito; Anne-Marie Bleau; Cameron Brennan; Dolares Hambardzumyan; Eric C Holland
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells.
Cell stem cell 2010;6(2):141-52.
2010: Elizabeth B Claus; May M. R. Abdel-Wahab; Peter C Burger; Herbert H Engelhard; David W Ellison; Nicholas Gaiano; David H Gutmann; Daniel A Heck; Eric C Holland; George I Jallo; Carol Kruchko; Larry E Kun; Bernard L Maria; Zoran Rumboldt; Daniela Seminara; Giovanna M Spinella; Linda Stophel; Robert Wechsler-Reya; Margaret Wrensch; Richard J Gilbertson
Defining future directions in spinal cord tumor research: proceedings from the National Institutes of Health workshop.
Journal of neurosurgery. Spine 2010;12(2):117-21.
2010: Nikki A Charles; Eric C Holland
TRRAP and the maintenance of stemness in gliomas.
Cell stem cell 2010;6(1):6-7.
2010: Brian M Howard; Demirkan B Gursel; Anne-Marie Bleau; Robel T Beyene; Eric C Holland; John A Boockvar
EGFR signaling is differentially activated in patient-derived glioblastoma stem cells.
Journal of experimental therapeutics & oncology 2010;8(3):247-60.
2010: Selvaraju Veeriah; Barry S Taylor; Shasha Meng; Fang Fang; Emrullah Yilmaz; Igor Vivanco; Manickam Janakiraman; Nikolaus Schultz; Aphrothiti J Hanrahan; William Pao; Marc Ladanyi; Chris Sander; Adriana Heguy; Eric C Holland; Philip B Paty; Paul Mischel; Linda Liau; Timothy F Cloughesy; Ingo K Mellinghoff; David B Solit; Timothy Chan
Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.
Nature genetics 2010;42(1):77-82.
2009: Jason Huse; Eric C Holland
Yin and yang: cancer-implicated miRNAs that have it both ways.
Cell cycle (Georgetown, Tex.) 2009;8(22):3611-2.
2009: Anne-Marie Bleau; Eric C Holland
[Chemotherapeutic treatment of gliomas increases the amount of cancer stem-like cells].
Médecine sciences : M/S 2009;25(10):775-7.
2009: Nikki Charles; Eric C Holland
Brain tumor treatment increases the number of cancer stem-like cells.
Expert review of neurotherapeutics 2009;9(10):1447-9.
2009: Nidhi Sabharwal; Eric C Holland; Maribel Vazquez
Live cell labeling of glial progenitor cells using targeted quantum dots.
Annals of biomedical engineering 2009;37(10):1967-73.
2009: Bobby Bhatia; Paul A Northcott; Dolares Hambardzumyan; Baskaran Govindarajan; Daniel J Brat; Jack L Arbiser; Eric C Holland; Michael D Taylor; Anna Marie Kenney
Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.
Cancer research 2009;69(18):7224-34.
2009: Anne-Marie Bleau; Jason Huse; Eric C Holland
The ABCG2 resistance network of glioblastoma.
Cell cycle (Georgetown, Tex.) 2009;8(18):2936-44.
2009: Nduka M Amankulor; Dolares Hambardzumyan; Stephanie M Pyonteck; Oren Josh Becher; Johanna A Joyce; Eric C Holland
Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(33):10299-308.
2009: Jason Huse; Cameron Brennan; Dolares Hambardzumyan; Boyoung Wee; John Pena; Sara H Rouhanifard; Cherin Sohn-Lee; Carlos le Sage; Reuven Agami; Thomas Tuschl; Eric C Holland
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.
Genes & development 2009;23(11):1327-37.
2009: Dolares Hambardzumyan; Nduka M Amankulor; Karim Y Helmy; Oren Josh Becher; Eric C Holland
Modeling Adult Gliomas Using RCAS/t-va Technology.
Translational oncology 2009;2(2):89-95.
2009: Anne-Marie Bleau; Dolares Hambardzumyan; Tatsuya Ozawa; Elena I Fomchenko; Jason Huse; Cameron Brennan; Eric C Holland
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.
Cell stem cell 2009;4(3):226-35.
2009: Fabienne Brenet; Nicholas D Socci; Nahum Sonenberg; Eric C Holland
Akt phosphorylation of La regulates specific mRNA translation in glial progenitors.
Oncogene 2009;28(1):128-39.
2009: Cameron Brennan; Hiroyuki Momota; Dolares Hambardzumyan; Tatsuya Ozawa; Adesh Tandon; Alicia Pedraza; Eric C Holland
Glioblastoma subclasses can be defined by activity among signal transduction pathways and associated genomic alterations.
PloS one 2009;4(11):e7752.
2009: Hiroyuki Momota; Eric C Holland
Mouse models of CNS embryonal tumors.
Brain tumor pathology 2009;26(2):43-50.
2009: Jason Huse; Eric C Holland
Genetically engineered mouse models of brain cancer and the promise of preclinical testing.
Brain pathology (Zurich, Switzerland) 2009;19(1):132-43.
2009: Arie Perry; Ryan Miller; Meena Gujrati; Bernd W Scheithauer; Sandro Casavilca Zambrano; Sarah C Jost; Ravi Raghavan; Jiang Qian; Elizabeth J Cochran; Jason Huse; Eric C Holland; Peter C Burger; Marc K Rosenblum
Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases.
Brain pathology (Zurich, Switzerland) 2009;19(1):81-90.
2008: Dolares Hambardzumyan; Massimo Squatrito; Eletha Carbajal; Eric C Holland
Glioma formation, cancer stem cells, and akt signaling.
Stem cell reviews 2008;4(3):203-10.
2008: H Momota; A H Shih; M A Edgar; Eric C Holland
c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice.
Oncogene 2008;27(32):4392-401.
2008: Dolares Hambardzumyan; Oren Josh Becher; Eric C Holland
Cancer stem cells and survival pathways.
Cell cycle (Georgetown, Tex.) 2008;7(10):1371-8.
2008: Veronica Dudu; Melissa Ramcharan; M Lane Gilchrist; Eric C Holland; Maribel Vazquez
Liposome delivery of quantum dots to the cytosol of live cells.
Journal of nanoscience and nanotechnology 2008;8(5):2293-300.
2008: Yelena Lyustikman; Hiroyuki Momota; William Pao; Eric C Holland
Constitutive activation of Raf-1 induces glioma formation in mice.
Neoplasia (New York, N.Y.) 2008;10(5):501-10.
2008: Oren Josh Becher; Dolares Hambardzumyan; Elena I Fomchenko; Hiroyuki Momota; Lori Mainwaring; Anne-Marie Bleau; Amanda M Katz; Mark A Edgar; Anna Marie Kenney; Carlos Cordon-Cardo; Ronald Blasberg; Eric C Holland
Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.
Cancer research 2008;68(7):2241-9.
2008: Michelle Bradbury; Dolares Hambardzumyan; Pat Zanzonico; Jazmin Schwartz; Shangde Cai; Eva M Burnazi; Valerie Longo; Steven M Larson; Eric C Holland
Dynamic small-animal PET imaging of tumor proliferation with 3'-deoxy-3'-18F-fluorothymidine in a genetically engineered mouse model of high-grade gliomas.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(3):422-9.
2008: Dolares Hambardzumyan; Oren Josh Becher; Marc K Rosenblum; Pier Paolo Pandolfi; Katia Manova-Todorova; Eric C Holland
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.
Genes & development 2008;22(4):436-48.
2008: Anne-Marie Bleau; Brian M Howard; Lauren A Taylor; Demirkan Gursel; Jeffrey P Greenfield; H Y Lim Tung; Eric C Holland; John A Boockvar
New strategy for the analysis of phenotypic marker antigens in brain tumor-derived neurospheres in mice and humans.
Neurosurgical focus 2008;24(3-4):E28.
2007: Andrew B Lassman; Eric C Holland
Incorporating molecular tools into clinical trials and treatment for gliomas?
Current opinion in neurology 2007;20(6):708-11.
2007: Yuhui Liu; Nancy Yeh; Xin-Hua Zhu; Margaret Leversha; Carlos Cordon-Cardo; Ronald A Ghossein; Bhuvanesh Singh; Eric C Holland; Andrew Koff
Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1).
The EMBO journal 2007;26(22):4683-93.
2007: Dolores Hambardzumyan; Yelena Lyustikman; Eric C Holland
An update on mouse brain tumor models in cancer drug discovery.
Expert opinion on drug discovery 2007;2(11):1435-51.
2007: E Tchougounova; M Kastemar; D Bråsäter; Eric C Holland; Bengt Westermark; Lene Uhrbom
Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma.
Oncogene 2007;26(43):6289-96.
2007: Limin Zhang; Kuei Lee; Mahaveer S Bhojani; Amjad P Khan; Alla Shilman; Eric C Holland; Brian D Ross; Alnawaz Rehemtulla
Molecular imaging of Akt kinase activity.
Nature medicine 2007;13(9):1114-9.
2007: Sarah M Dunlap; Joseph Celestino; Hua Wang; Rongcai Jiang; Eric C Holland; Gregory N Fuller; Wei Zhang
Insulin-like growth factor binding protein 2 promotes glioma development and progression.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11736-41.
2007: Patrick McConville; Dolares Hambardzumyan; Jonathan B Moody; Wilbur R Leopold; Alicia R Kreger; Michael J Woolliscroft; Alnawaz Rehemtulla; Brian D Ross; Eric C Holland
Magnetic resonance imaging determination of tumor grade and early response to temozolomide in a genetically engineered mouse model of glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):2897-904.
2007: Anne-Marie Bleau; Eric C Holland
Trapping the mouse genome to hunt human alterations.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(19):7737-8.
2007: Sarah V Bradley; Eric C Holland; Grace Y Liu; Dafydd Thomas; Teresa S Hyun; Theodora S Ross
Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor.
Cancer research 2007;67(8):3609-15.
2007: Elena I Fomchenko; Eric C Holland
Platelet-derived growth factor-mediated gliomagenesis and brain tumor recruitment.
Neurosurgery clinics of North America 2007;18(1):39-58, viii.
2006: Alan H Shih; Eric C Holland
Notch signaling enhances nestin expression in gliomas.
Neoplasia (New York, N.Y.) 2006;8(12):1072-82.
2006: Dolares Hambardzumyan; Massimo Squatrito; Massimo Squartro; Eric C Holland
Radiation resistance and stem-like cells in brain tumors.
Cancer cell 2006;10(6):454-6.
2006: Adília Hormigo; Bin Gu; Sasan Karimi; Elyn Riedel; Katherine S Panageas; Mark A Edgar; Meena K Tanwar; Jasti Sambasiva Rao; Martin Fleisher; Lisa De Angelis; Eric C Holland
YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(19):5698-704.
2006: Elena I Fomchenko; Eric C Holland
Mouse models of brain tumors and their applications in preclinical trials.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(18):5288-97.
2006: Elena I Fomchenko; Eric C Holland
Origins of brain tumors--a disease of stem cells?
Nature clinical practice. Neurology 2006;2(6):288-9.
2006: Oren Josh Becher; Eric C Holland
Genetically engineered models have advantages over xenografts for preclinical studies.
Cancer research 2006;66(7):3355-8, discussion 3358-9.
2006: Alan H Shih; Eric C Holland
Platelet-derived growth factor (PDGF) and glial tumorigenesis.
Cancer letters 2006;232(2):139-47.
2006: Josep Villanueva; David R Shaffer; John Philip; Carlos A Chaparro; Hediye Erdjument-Bromage; Adam B Olshen; Martin Fleisher; Hans Lilja; Edi Brogi; Jeff Boyd; Marta Sanchez-Carbayo; Eric C Holland; Carlos Cordon-Cardo; Howard I Scher; Paul Tempst
Differential exoprotease activities confer tumor-specific serum peptidome patterns.
The Journal of clinical investigation 2006;116(1):271-84.
2005: Hiroyuki Momota; Eric C Holland
Bioluminescence technology for imaging cell proliferation.
Current opinion in biotechnology 2005;16(6):681-6.
2005: Andrew B Lassman; Michael R Rossi; Jeffrey J Raizer; Jeffrey R Razier; Lauren E Abrey; Frank S Lieberman; Chelsea N Grefe; Kathleen R Lamborn; William Pao; Alan H Shih; John Kuhn; Richard Wilson; Norma J Nowak; John Kenneth Cowell; Lisa De Angelis; Patrick Y Wen; Mark R Gilbert; Susan Chang; W A Yung; Michael Prados; Eric C Holland
Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(21):7841-50.
2005: Xiaoyi Hu; Eric C Holland
Applications of mouse glioma models in preclinical trials.
Mutation research 2005;576(1-2):54-65.
2005: Hiroyuki Momota; Edward Nerio; Eric C Holland
Perifosine inhibits multiple signaling pathways in glial progenitors and cooperates with temozolomide to arrest cell proliferation in gliomas in vivo.
Cancer research 2005;65(16):7429-35.
2005: Elena I Fomchenko; Eric C Holland
Stem cells and brain cancer.
Experimental cell research 2005;306(2):323-9.
2005: Chengkai Dai; Yelena Lyustikman; Alan H Shih; Xiaoyi Hu; Gregory N Fuller; Marc K Rosenblum; Eric C Holland
The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats.
Neoplasia (New York, N.Y.) 2005;7(4):397-406.
2005: Xiaoyi Hu; Pier Paolo Pandolfi; Yi Li; Jason A Koutcher; Marc K Rosenblum; Eric C Holland
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.
Neoplasia (New York, N.Y.) 2005;7(4):356-68.
2005: Lene Uhrbom; Marianne Kastemar; Fredrik K Johansson; Bengt Westermark; Eric C Holland
Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.
Cancer research 2005;65(6):2065-9.
2005: Violetta Barbashina; Paulo Salazar; Eric C Holland; Marc K Rosenblum; Marc Ladanyi
Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(3):1119-28.
2005: Maria Salpietro; Eric C Holland
Modeling and preclinical trials for gliomas.
Clinical neurosurgery 2005;52():104-11.
2004: Andrew T Parsa; Eric C Holland
Cooperative translational control of gene expression by Ras and Akt in cancer.
Trends in molecular medicine 2004;10(12):607-13.
2004: Alan H Shih; Eric C Holland
Developmental neurobiology and the origin of brain tumors.
Journal of neuro-oncology 2004;70(2):125-36.
2004: Lene Uhrbom; Edward Nerio; Eric C Holland
Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.
Nature medicine 2004;10(11):1257-60.
2004: Eric C Holland
Mouse models of human cancer as tools in drug development.
Cancer cell 2004;6(3):197-8.
2004: Jakob Dupont; Meena K Tanwar; Howard T Thaler; Martin Fleisher; Noah D Kauff; Martee Hensley; Paul Sabbatini; Sibyl Anderson; Carol Aghajanian; Eric C Holland; David Spriggs
Early detection and prognosis of ovarian cancer using serum YKL-40.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(16):3330-9.
2004: Ganesh Rao; Carolyn A Pedone; Luis Del Valle; Krzysztof Reiss; Eric C Holland; Daniel W Fults
Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice.
Oncogene 2004;23(36):6156-62.
2004: Alan H Shih; Chengkai Dai; Xiaoyi Hu; Marc K Rosenblum; Jason A Koutcher; Eric C Holland
Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis.
Cancer research 2004;64(14):4783-9.
2004: Andrew B Lassman; Chengkai Dai; Gregory N Fuller; Andrew J Vickers; Eric C Holland
Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice.
Neuron glia biology 2004;1(2):157-63.
2004: Vinagolu K Rajasekhar; Eric C Holland
Postgenomic global analysis of translational control induced by oncogenic signaling.
Oncogene 2004;23(18):3248-64.
2004: Eric C Holland; Nahum Sonenberg; Pier Paolo Pandolfi; George Thomas
Signaling control of mRNA translation in cancer pathogenesis.
Oncogene 2004;23(18):3138-44.
2004: Eric C Holland
Regulation of translation and cancer.
Cell cycle (Georgetown, Tex.) 2004;3(4):452-5.
2004: Josep Villanueva; John Philip; David Entenberg; Carlos A Chaparro; Meena K Tanwar; Eric C Holland; Paul Tempst
Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry.
Analytical chemistry 2004;76(6):1560-70.
2004: Federic P Collignon; Eric C Holland; Sandy Feng
Organ donors with malignant gliomas: an update.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(1):15-21.
2003: Vinagolu K Rajasekhar; Agnes Viale; Nicholas D Socci; Martin Wiedmann; Xiaoyi Hu; Eric C Holland
Oncogenic Ras and Akt signaling contribute to glioblastoma formation by differential recruitment of existing mRNAs to polysomes.
Molecular cell 2003;12(4):889-901.
2003: Göran Hesselager; Eric C Holland
Using mice to decipher the molecular genetics of brain tumors.
Neurosurgery 2003;53(3):685-94; discussion 695.
2003: Ganesh Rao; Carolyn A Pedone; Cheryl M Coffin; Eric C Holland; Daniel W Fults
c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice.
Neoplasia (New York, N.Y.) 2003;5(3):198-204.
2003: Chengkai Dai; Eric C Holland
Astrocyte differentiation states and glioma formation.
Cancer journal (Sudbury, Mass.) 2003;9(2):72-81.
2003: Su Xu; Terence P F Gade; Cornelia Matei; Kristen L Zakian; Alan Alfieri; Xiaoyi Hu; Eric C Holland; S Soghomonian; Juri Gelovani Tjuvajev; Douglas Ballon; Jason A Koutcher
In vivo multiple-mouse imaging at 1.5 T.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;49(3):551-7.
2003: Rebecca M Wolf; Nicole Draghi; Xiquan Liang; Chengkai Dai; Lene Uhrbom; Charlotta Eklöf; Bengt Westermark; Eric C Holland; Marilyn D Resh
p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3.
Genes & development 2003;17(4):476-87.
2002: Jason A Koutcher; Xiaoyi Hu; Su Xu; Terence P F Gade; Norman Leeds; Xiaohong Joe Zhou; David Zagzag; Eric C Holland
MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials.
Neoplasia (New York, N.Y.) 2002;4(6):480-5.
2002: William A Weiss; Mark Israel; Charles S Cobbs; Eric C Holland; C David James; David N Louis; Cheryl Marks; Andrea I McClatchey; Tim Roberts; Terry Van Dyke; Cynthia Wetmore; Ing-Ming Chiu; Marco Giovannini; Abhijit Guha; Robert J Higgins; Silvia Marino; Ivan Radovanovic; Karlyne M Reilly; Kenneth Aldape
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum.
Oncogene 2002;21(49):7453-63.
2002: Lene Uhrbom; Chengkai Dai; Joseph Celestino; Marc K Rosenblum; Gregory N Fuller; Eric C Holland
Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.
Cancer research 2002;62(19):5551-8.
2002: Maria P De Miguel; Linzhao Cheng; Eric C Holland; Mark J Federspiel; Peter J Donovan
Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10458-63.
2002: Meena K Tanwar; Mark R Gilbert; Eric C Holland
Gene expression microarray analysis reveals YKL-40 to be a potential serum marker for malignant character in human glioma.
Cancer research 2002;62(15):4364-8.
2002: L van Rompaey; Eric C Holland; Gerard C Grosveld
TEL Induces Aggregation in Transformed Cells and Induces Tube Formation in NIH3T3-UCLA Cells.
Biochemical and biophysical research communications 2002;291(4):820-8.
2002: Daniel W Fults; Carolyn A Pedone; Chengkai Dai; Eric C Holland
MYC expression promotes the proliferation of neural progenitor cells in culture and in vivo.
Neoplasia (New York, N.Y.) 2002;4(1):32-9.
2002: Martin Begemann; Gregory N Fuller; Eric C Holland
Genetic modeling of glioma formation in mice.
Brain pathology (Zurich, Switzerland) 2002;12(1):117-32.
2001: Eric C Holland
Progenitor cells and glioma formation.
Current opinion in neurology 2001;14(6):683-8.
2001: Frederick F Lang; N E Olansen; Franco DeMonte; Ziya L Gokaslan; Eric C Holland; C Kalhorn; Raymond Sawaya
Surgical resection of intrinsic insular tumors: complication avoidance.
Journal of neurosurgery 2001;95(4):638-50.
2001: David N Louis; Eric C Holland; J Gregory Cairncross
Glioma classification: a molecular reappraisal.
The American journal of pathology 2001;159(3):779-86.
2001: Chengkai Dai; Eric C Holland
Glioma models.
Biochimica et biophysica acta 2001;1551(1):M19-27.
2001: M Lacroix; D Abi-Said; Daryl R Fourney; Ziya L Gokaslan; Weiming Shi; Franco DeMonte; Frederick F Lang; Ian E McCutcheon; Samuel J Hassenbusch; Eric C Holland; K Hess; C Michael; D Miller; Raymond Sawaya
A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival.
Journal of neurosurgery 2001;95(2):190-8.
2001: Chengkai Dai; Joseph Celestino; Y Okada; David N Louis; Gregory N Fuller; Eric C Holland
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo.
Genes & development 2001;15(15):1913-25.
2001: Lene Uhrbom; Eric C Holland
Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors.
Journal of neuro-oncology 2001;53(3):297-305.
2001: Eric C Holland
Brain tumor animal models: importance and progress.
Current opinion in oncology 2001;13(3):143-7.
2001: Eric C Holland
Animal models of cell cycle dysregulation and the pathogenesis of gliomas.
Journal of neuro-oncology 2001;51(3):265-76.
2001: Eric C Holland
Gliomagenesis: genetic alterations and mouse models.
Nature reviews. Genetics 2001;2(2):120-9.
2000: Eric D Laywell; P Rakic; Valery G Kukekov; Eric C Holland; Dennis A Steindler
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13883-8.
2000: Eric C Holland; Y Li; Joseph Celestino; Chengkai Dai; L Schaefer; R A Sawaya; Gregory N Fuller
Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo.
The American journal of pathology 2000;157(3):1031-7.
2000: L S Caskey; Gregory N Fuller; Janet M Bruner; W K Yung; R E Sawaya; Eric C Holland; Wei Zhang
Toward a molecular classification of the gliomas: histopathology, molecular genetics, and gene expression profiling.
Histology and histopathology 2000;15(3):971-81.
2000: Eric C Holland
Glioblastoma multiforme: the terminator.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6242-4.
2000: Eric C Holland; Joseph Celestino; Chengkai Dai; L Schaefer; R E Sawaya; Gregory N Fuller
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice.
Nature genetics 2000;25(1):55-7.
2000: Eric C Holland
A mouse model for glioma: biology, pathology, and therapeutic opportunities.
Toxicologic pathology 2000;28(1):171-7.
1999: Galen H Fisher; Sandra Orsulic; Eric C Holland; WP Hively; Yi Li; Brian C Lewis; Bart Williams; Harold Varmus
Development of a flexible and specific gene delivery system for production of murine tumor models.
Oncogene 1999;18(38):5253-60.
1998: Eric C Holland; WP Hively; Ronald A DePinho; Harold Varmus
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.
Genes & development 1998;12(23):3675-85.
1998: Eric C Holland; WP Hively; V Gallo; Harold Varmus
Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes.
Genes & development 1998;12(23):3644-9.
1998: Eric C Holland; Harold Varmus
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1218-23.
1988: S Feng; Eric C Holland
HIV-1 tat trans-activation requires the loop sequence within tar.
Nature 1988;334(6178):165-7.
1987: D F Halberg; R E Wager; D C Farrell; J Hildreth; M S Quesenberry; Jeffrey A Loeb; Eric C Holland; Kurt Drickamer
Major and minor forms of the rat liver asialoglycoprotein receptor are independent galactose-binding proteins. Primary structure and glycosylation heterogeneity of minor receptor forms.
The Journal of biological chemistry 1987;262(20):9828-38.
1986: E C Hsueh; Eric C Holland; G M Carrera; Kurt Drickamer
The rat liver asialoglycoprotein receptor polypeptide must be inserted into a microsome to achieve its active conformation.
The Journal of biological chemistry 1986;261(11):4940-7.
1986: Eric C Holland; Kurt Drickamer
Signal recognition particle mediates the insertion of a transmembrane protein which has a cytoplasmic NH2 terminus.
The Journal of biological chemistry 1986;261(3):1286-92.
1985: J O Leung; Eric C Holland; Kurt Drickamer
Characterization of the gene encoding the major rat liver asialoglycoprotein receptor.
The Journal of biological chemistry 1985;260(23):12523-7.
1984: Eric C Holland; J O Leung; Kurt Drickamer
Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(23):7338-42.