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Georg Holländer

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Anatomy

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Saulius Zuklys; Thomas Barthlott; Bruce R Blazar; Stephane Chappaz; James Dooley; Daniela Finke; Jason Gill; Adrian Liston; Carlos E Mayer; Takeshi Nitta; Ruben Nogales-Cadenas; Gretel Nusspaumer; Alberto Pascual-Montano; Heather E Stefanski; Yousuke Takahama; Saule Zhanybekova; Georg A Holländer
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.
Javier Lopez-Rios; Gretel Nusspaumer; Marco Osterwalder; Dimitri Robay; Martina Scotti; Dario Speziale; Antonella Galli; Georg A Holländer; Marie Kmita; Rolf Zeller
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.
Werner Krenger; Bruce R Blazar; Georg A Holländer
Thymic T-cell development in allogeneic stem cell transplantation.

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2012: Saulius Zuklys; Thomas Barthlott; Bruce R Blazar; Stephane Chappaz; James Dooley; Daniela Finke; Jason Gill; Adrian Liston; Carlos E Mayer; Takeshi Nitta; Ruben Nogales-Cadenas; Gretel Nusspaumer; Alberto Pascual-Montano; Heather E Stefanski; Yousuke Takahama; Saule Zhanybekova; Georg A Holländer
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(8):3894-904.
2012: Javier Lopez-Rios; Gretel Nusspaumer; Marco Osterwalder; Dimitri Robay; Martina Scotti; Dario Speziale; Antonella Galli; Georg A Holländer; Marie Kmita; Rolf Zeller
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis.
Developmental cell 2012;22(4):837-48.
2011: Werner Krenger; Bruce R Blazar; Georg A Holländer
Thymic T-cell development in allogeneic stem cell transplantation.
Blood 2011;117(25):6768-76.
2010: Georg A Holländer; Werner Krenger; Bruce R Blazar
Emerging strategies to boost thymic function.
Current opinion in pharmacology 2010;10(4):443-53.
2010: Ryan M Kelly; Emily M Goren; Patricia A Taylor; Scott N Mueller; Heather Emily Stefanski; Mark J Osborn; Hamish S Scott; Elena A Komarova; Andrei V Gudkov; Georg A Holländer; Bruce R Blazar
Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.
Blood 2010;115(5):1088-97.
2010: Elisabeth Fayard; Gerald Moncayo; Brian A Hemmings; Georg A Holländer
Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control.
Science signaling 2010;3(135):re5.
2010: Linda Kenins; Jason W Gill; Georg A Holländer; Aleksandra Wodnar-Filipowicz
Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis.
European journal of immunology 2010;40(1):81-90.
2009: Noriko Shikama; Gretel Nusspaumer; Georg A Holländer
Clearing the AIRE: on the pathophysiological basis of the autoimmune polyendocrinopathy syndrome type-1.
Endocrinology and metabolism clinics of North America 2009;38(2):273-88, vii.
2009: Georg A Holländer; P Peterson
Learning to be tolerant: how T cells keep out of trouble.
Journal of internal medicine 2009;265(5):541-61.
2009: Saulius Zuklys; Jason Gill; Marcel P Keller; Mathias Hauri-Hohl; Saule Zhanybekova; Gina Balciunaite; Kyung-Jae Na; Lukas T Jeker; Katrin Hafen; Noriyuki Tsukamoto; Takashi Amagai; Makoto M Taketo; Werner Krenger; Georg A Holländer
Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2997-3007.
2008: Werner Krenger; Georg A Holländer
The immunopathology of thymic GVHD.
Seminars in immunopathology 2008;30(4):439-56.
2008: Georg A Holländer
Lymphoid reconstitution following hematopoietic stem cell transplantation. Of mice and men: progress made in HSCT immunobiology.
Seminars in immunopathology 2008;30(4):369-70.
2008: Lukas T Jeker; Thomas Barthlott; Marcel P Keller; Saulius Zuklys; Mathias Hauri-Hohl; Chu-Xia Deng; Georg A Holländer
Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells.
Blood 2008;112(9):3688-95.
2008: Katsuto Hozumi; Carolina Mailhos; Naoko Negishi; Ken-ichi Hirano; T Yahata; Kiyoshi Ando; Saulius Zuklys; Georg A Holländer; David T Shima; Sonoko Habu
Delta-like 4 is indispensable in thymic environment specific for T cell development.
The Journal of experimental medicine 2008;205(11):2507-13.
2008: Magali Irla; Stéphanie Hugues; Jason Gill; Takeshi Nitta; Yu Hikosaka; Ifor Williams; FX Hubert; Hamish Scott; Yousuke Takahama; Georg A Holländer; Walter Reith
Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.
Immunity 2008;29(3):451-63.
2008: Mathias M Hauri-Hohl; Saulius Zuklys; Marcel P Keller; Lukas T Jeker; Thomas Barthlott; Anne M Moon; Jürgen Roes; Georg A Holländer
TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
Blood 2008;112(3):626-34.
2008: Ryan M Kelly; Steven L Highfill; Angela Panoskaltsis-Mortari; Patricia A Taylor; Richard L Boyd; Georg A Holländer; Bruce R Blazar
Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation.
Blood 2008;111(12):5734-44.
2008: Werner Krenger; Georg A Holländer
The thymus in GVHD pathophysiology.
Best practice & research. Clinical haematology 2008;21(2):119-28.
2008: Mathias Heikenwalder; Marco Prinz; Nicolas Zeller; Karl S Lang; Tobias Junt; Simona Rossi; Alexei Tumanov; Hauke Schmidt; Josef Priller; Lukas Flatz; Thomas Rülicke; Andrew J Macpherson; Georg A Holländer; Sergei A Nedospasov; Adriano Aguzzi
Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
The American journal of pathology 2008;172(6):1555-70.
2008: Linda Kenins; Jason W Gill; Richard L Boyd; Georg A Holländer; Aleksandra Wodnar-Filipowicz
Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation.
The Journal of experimental medicine 2008;205(3):523-31.
2008: Mohammad Alimohammadi; Peyman Björklund; Asa Hallgren; Nora Pöntynen; Gabor Szinnai; Noriko Shikama; Marcel P Keller; Olov Ekwall; Sarah A Kinkel; Eystein S Husebye; Jan Gustafsson; Fredrik Rorsman; Leena Peltonen; Corrado Betterle; Jaakko Perheentupa; Göran Akerström; Gunnar Westin; Hamish Scott; Georg A Holländer; Kämpe Olle
Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.
The New England journal of medicine 2008;358(10):1018-28.
2007: Mathias M Hauri-Hohl; Marcel P Keller; Jason Gill; Katrin Hafen; Esther Pachlatko; Thomas Boulay; Annick Peter; Georg A Holländer; Werner Krenger
Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.
Blood 2007;109(9):4080-8.
2007: Simona Rossi; Lukas T Jeker; Tomoo Ueno; Sachiyo Kuse; Marcel P Keller; Saulius Zuklys; Andrei V Gudkov; Yousuke Takahama; Werner Krenger; Bruce R Blazar; Georg A Holländer
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.
Blood 2007;109(9):3803-11.
2007: Dullei Min; Angela Panoskaltsis-Mortari; Makoto Kuro-o; Georg A Holländer; Bruce R Blazar; Kenneth I Weinberg
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging.
Blood 2007;109(6):2529-37.
2007: Thomas Barthlott; Marcel P Keller; Werner Krenger; Georg A Holländer
A short primer on early molecular and cellular events in thymus organogenesis and replacement.
Swiss medical weekly 2007;137 Suppl 155():9S-13S.
2007: Georg A Holländer
Claudins provide a breath of fresh Aire.
Nature immunology 2007;8(3):234-6.
2007: Elisabeth Fayard; Jason Gill; Magdalena Paolino; Debby Hynx; Georg A Holländer; Brian A Hemmings
Deletion of PKBalpha/Akt1 affects thymic development.
PloS one 2007;2(10):e992.
2006: Mark A Daniels; Emma Teixeiro; Jason Gill; Barbara Hausmann; Dominique Roubaty; Kaisa Holmberg; Guy Werlen; Georg A Holländer; Nicholas R J Gascoigne; Ed Palmer
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.
Nature 2006;444(7120):724-9.
2006: Michael Decker; Christian Rothermundt; Georg A Holländer; André Tichelli; Christoph Rochlitz
Rituximab plus CHOP for treatment of diffuse large B-cell lymphoma during second trimester of pregnancy.
The lancet oncology 2006;7(8):693-4.
2006: Thomas Barthlott; Marcel P Keller; Werner Krenger; Georg A Holländer
A short primer on early molecular and cellular events in thymus organogenesis and replacement.
Swiss medical weekly 2006;136(23-24):365-9.
2006: Georg A Holländer; Jason Gill; Saulius Zuklys; Norimasa Iwanami; Cunlan Liu; Yousuke Takahama
Cellular and molecular events during early thymus development.
Immunological reviews 2006;209():28-46.
2005: Anna-Margaretha Wagner; Konstantin Beier; Elli Christen; Georg A Holländer; Werner Krenger
Leydig cell injury as a consequence of an acute graft-versus-host reaction.
Blood 2005;105(7):2988-90.
2004: Werner Krenger; Heike Schmidlin; Gionata Cavadini; Georg A Holländer
On the relevance of TCR rearrangement circles as molecular markers for thymic output during experimental graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7359-67.
2002: Simona Frigerio; Tobias Junt; Bao Lu; Craig Gerard; Urs Zumsteg; Georg A Holländer; Luca Piali
Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.
Nature medicine 2002;8(12):1414-20.
2002: Gina Balciunaite; Marcel P Keller; Egle Balciunaite; Luca Piali; Saulius Zuklys; Yves D Mathieu; Jason Gill; Richard Boyd; Daniel J Sussman; Georg A Holländer
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.
Nature immunology 2002;3(11):1102-8.
2002: Simona Rossi; Bruce R Blazar; Kate Farrell; Dimitry M Danilenko; David L Lacey; Kenneth I Weinberg; Werner Krenger; Georg A Holländer
Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease.
Blood 2002;100(2):682-91.
2002: Jason Gill; Mark A Malin; Georg A Holländer; Richard Boyd
Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells.
Nature immunology 2002;3(7):635-42.
2002: Simona Frigerio; Georg A Holländer; Urs Zumsteg
Functional IL-18 Is produced by primary pancreatic mouse islets and NIT-1 beta cells and participates in the progression towards destructive insulitis.
Hormone research 2002;57(3-4):94-104.
2000: Saulius Zuklys; Gina Balciunaite; A Agarwal; Elizaveta Fasler-Kan; Ed Palmer; Georg A Holländer
Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Journal of immunology (Baltimore, Md. : 1950) 2000;165(4):1976-83.
2000: Werner Krenger; Simona Rossi; Luca Piali; Georg A Holländer
Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells.
Blood 2000;96(1):347-54.
2000: Werner Krenger; Simona Rossi; Georg A Holländer
Apoptosis of thymocytes during acute graft-versus-host disease is independent of glucocorticoids.
Transplantation 2000;69(10):2190-3.
2000: Urs Zumsteg; S Frigerio; Georg A Holländer
Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage.
Diabetes 2000;49(1):39-47.
1999: E Förster; Werner Krenger; J Joergensen; Robert P Hof; R S Geha; Georg A Holländer
Contribution of CD40-CD154-mediated costimulation to an alloresponse in vivo.
Transplantation 1999;67(9):1284-7.
1999: Georg A Holländer; Saulius Zuklys; E Förster; Werner Krenger
On costimulatory signals and T cell tolerance: relevance for transplantation immunity.
Transplantation proceedings 1999;31(1-2A):25S-31S.
1998: Georg A Holländer; Saulius Zuklys; C Morel; E Mizoguchi; K Mobisson; S Simpson; C Terhorst; W Wishart; D E Golan; A K Bhan; S J Burakoff
Monoallelic expression of the interleukin-2 locus.
Science (New York, N.Y.) 1998;279(5359):2118-21.
1997: Baoping Wang; Stephen J Simpson; Georg A Holländer; Cox Terhorst
Development and function of T lymphocytes and natural killer cells after bone marrow transplantation of severely immunodeficient mice.
Immunological reviews 1997;157():53-60.
1997: J She; Stephen J Simpson; A Gupta; Georg A Holländer; CN Levelt; C P Liu; D Allen; Nancy Van Houten; Baoping Wang; Cox Terhorst
CD16-expressing CD8alpha alpha+ T lymphocytes in the intestinal epithelium: possible precursors of Fc gammaR-CD8alpha alpha+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4678-87.
1997: Stephen J Simpson; Georg A Holländer; Emiko Mizoguchi; D Allen; Atul K Bhan; Baoping Wang; Cox Terhorst
Expression of pro-inflammatory cytokines by TCR alpha beta+ and TCR gamma delta+ T cells in an experimental model of colitis.
European journal of immunology 1997;27(1):17-25.
1996: Georg A Holländer; E Castigli; R Kulbacki; M Su; Steven J Burakoff; Jose-Carlos Gutierrez-Ramos; R S Geha
Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4994-8.
1995: Georg A Holländer; Stephen J Simpson; E Mizoguchi; A Nichogiannopoulou; J She; Jose-Carlos Gutierrez-Ramos; A K Bhan; Steven J Burakoff; Baoping Wang; Cox Terhorst
Severe colitis in mice with aberrant thymic selection.
Immunity 1995;3(1):27-38.
1995: S Simpson; Georg A Holländer; J She; C Levelt; M Huang; Cox Terhorst
Selection of peripheral and intestinal T lymphocytes lacking CD3 zeta.
International immunology 1995;7(2):287-93.
1995: Georg A Holländer; B Wang; A Nichogiannopoulou; P P Platenburg; W van Ewijk; Steven J Burakoff; Jose-Carlos Gutierrez-Ramos; Cox Terhorst
Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.
Nature 1995;373(6512):350-3.
1994: Georg A Holländer; David A Fruman; B E Bierer; Steven J Burakoff
Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo.
Transplantation 1994;58(9):1037-43.
1994: Georg A Holländer; B E Bierer; Steven J Burakoff
Molecular and biological actions of cyclosporin A and FK506 on T cell development and function.
Transfusion science 1994;15(3):207-20.
1994: Georg A Holländer; B Widmer; Steven J Burakoff
Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1609-17.
1992: Georg A Holländer; B D Luskey; D A Williams; Steven J Burakoff
Functional expression of human CD8 in fully reconstituted mice after retroviral-mediated gene transfer of hemopoietic stem cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):438-44.