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Diane Hollenbaugh

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Christopher R Gilson; Zvonimir Milas; Shivaprakash Gangappa; Diane L Hollenbaugh; Thomas C Pearson; Mandy L Ford; Christian P Larsen
Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.
Dominique Potin; Michele Launay; Eric Nicolai; Maud Fabreguette; Patrice Malabre; François Caussade; Dominique Besse; Stacey Skala; Dawn K Stetsko; Gordon Todderud; Brett R Beno; Daniel L Cheney; Chiehying J Chang; Steven Sheriff; Diane L Hollenbaugh; Joel C Barrish; Edwin Iwanowicz; Suzanne J Suchard; T G Murali Dhar
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.
Andrew B Adams; Nozomu Shirasugi; Thomas R Jones; Megan M Durham; Elizabeth Strobert; Shannon Cowan; Phyllis Rees; Rose Hendrix; Karen Price; Norma S Kenyon; David Hagerty; Robert Townsend; Diane L Hollenbaugh; Thomas C Pearson; Christian P Larsen
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.

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2009: Christopher R Gilson; Zvonimir Milas; Shivaprakash Gangappa; Diane L Hollenbaugh; Thomas C Pearson; Mandy L Ford; Christian P Larsen
Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1625-35.
2005: Dominique Potin; Michele Launay; Eric Nicolai; Maud Fabreguette; Patrice Malabre; François Caussade; Dominique Besse; Stacey Skala; Dawn K Stetsko; Gordon Todderud; Brett R Beno; Daniel L Cheney; Chiehying J Chang; Steven Sheriff; Diane L Hollenbaugh; Joel C Barrish; Edwin Iwanowicz; Suzanne J Suchard; T G Murali Dhar
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.
Bioorganic & medicinal chemistry letters 2005;15(4):1161-4.
2005: Andrew B Adams; Nozomu Shirasugi; Thomas R Jones; Megan M Durham; Elizabeth Strobert; Shannon Cowan; Phyllis Rees; Rose Hendrix; Karen Price; Norma S Kenyon; David Hagerty; Robert Townsend; Diane L Hollenbaugh; Thomas C Pearson; Christian P Larsen
Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):542-50.
2003: T G Murali Dhar; Zhongqi Shen; Henry Gu; Ping Chen; Derek Norris; Scott H Watterson; Shelley K Ballentine; Catherine A Fleener; Katherine A Rouleau; Joel C Barrish; Robert Townsend; Diane L Hollenbaugh; Edwin Iwanowicz
3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Bioorganic & medicinal chemistry letters 2003;13(20):3557-60.
2003: Edwin Iwanowicz; Scott H Watterson; Junqing Guo; William J Pitts; TG Murali Dhar; Zhongqi Shen; Ping Chen; Henry Gu; Catherine A Fleener; Katherine A Rouleau; Daniel L Cheney; Robert M Townsend; Diane L Hollenbaugh
Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.
Bioorganic & medicinal chemistry letters 2003;13(12):2059-63.
2003: Ping Chen; Derek Norris; Kristin D Haslow; TG Murali Dhar; William J Pitts; Scott H Watterson; Daniel L Cheney; Donna A Bassolino; Catherine A Fleener; Katherine A Rouleau; Diane L Hollenbaugh; Robert M Townsend; Joel C Barrish; Edwin Iwanowicz
Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(7):1345-8.
2003: Scott H Watterson; T G Murali Dhar; Shelley K Ballentine; Zhongqi Shen; Joel C Barrish; Daniel L Cheney; Catherine A Fleener; Katherine A Rouleau; Robert Townsend; Diane L Hollenbaugh; Edwin Iwanowicz
Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.
Bioorganic & medicinal chemistry letters 2003;13(7):1273-6.
2003: T G Murali Dhar; Scott H Watterson; Ping Chen; Zhongqi Shen; Henry Gu; Derek Norris; Marianne Carlsen; Kristin D Haslow; William J Pitts; Junqing Guo; John Chorba; Catherine A Fleener; Katherine A Rouleau; Robert Townsend; Diane L Hollenbaugh; Edwin Iwanowicz
Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.
Bioorganic & medicinal chemistry letters 2003;13(3):547-51.
2003: Scott H Watterson; Marianne Carlsen; T G Murali Dhar; Zhongqi Shen; William J Pitts; Junqing Guo; Henry Gu; Derek Norris; John Chorba; Ping Chen; Daniel L Cheney; Mark R Witmer; Catherine A Fleener; Katherine A Rouleau; Robert Townsend; Diane L Hollenbaugh; Edwin Iwanowicz
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Bioorganic & medicinal chemistry letters 2003;13(3):543-6.
2002: T G Murali Dhar; Zhongqi Shen; Catherine A Fleener; Katherine A Rouleau; Joel C Barrish; Diane L Hollenbaugh; Edwin Iwanowicz
The TosMIC approach to 3-(oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(22):3305-8.
2002: T G Murali Dhar; Chunjian Liu; William J Pitts; Junquing Guo; Scott H Watterson; Henry Gu; Catherine A Fleener; Katherine A Rouleau; NZ Sherbina; Joel C Barrish; Diane L Hollenbaugh; Edwin Iwanowicz
A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.
Bioorganic & medicinal chemistry letters 2002;12(21):3125-8.
2002: Edwin Iwanowicz; Scott H Watterson; Chunjian Liu; Henry Gu; Toomas Mitt; Katerina Leftheris; Joel C Barrish; Catherine A Fleener; Katherine A Rouleau; NZ Sherbina; Diane L Hollenbaugh
Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.
Bioorganic & medicinal chemistry letters 2002;12(20):2931-4.
2002: Scott H Watterson; Chunjian Liu; T G Murali Dhar; Henry Gu; William J Pitts; Joel C Barrish; Catherine A Fleener; Katherine A Rouleau; NZ Sherbina; Diane L Hollenbaugh; Edwin Iwanowicz
Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.
Bioorganic & medicinal chemistry letters 2002;12(20):2879-82.
2002: Thomas C Pearson; Joel Trambley; Kris Odom; Daniel Anderson; Shannon Cowan; Robert A. Bray; Angello Lin; Diane L Hollenbaugh; Alejandro Aruffo; Anthony W Siadak; Elizabeth Strobert; Randolph A Hennigar; Christian P Larsen
Anti-CD40 therapy extends renal allograft survival in rhesus macaques.
Transplantation 2002;74(7):933-40.
2002: William J Pitts; Junqing Guo; T G Murali Dhar; Zhongqi Shen; Henry Gu; Scott H Watterson; Mark S Bednarz; Bang-Chi Chen; Joel C Barrish; Donna A Bassolino; Daniel L Cheney; Catherine A Fleener; Katherine A Rouleau; Diane L Hollenbaugh; Edwin Iwanowicz
Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
Bioorganic & medicinal chemistry letters 2002;12(16):2137-40.
2002: T G Murali Dhar; Zhongqi Shen; Junqing Guo; Chunjian Liu; Scott H Watterson; Henry Gu; William J Pitts; Catherine A Fleener; Katherine A Rouleau; NZ Sherbina; Kim W McIntyre; David J Shuster; Mark R Witmer; Jeffrey A Tredup; Bang-Chi Chen; Rulin Zhao; Mark S Bednarz; Daniel L Cheney; John F MacMaster; Laura M Miller; Karen K Berry; Timothy W Harper; Joel C Barrish; Diane L Hollenbaugh; Edwin Iwanowicz
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.
Journal of medicinal chemistry 2002;45(11):2127-30.
2002: Henry Gu; Edwin Iwanowicz; Junqing Guo; Scott H Watterson; Zhongqi Shen; William J Pitts; T G Murali Dhar; Catherine A Fleener; Katherine A Rouleau; NZ Sherbina; Mark R Witmer; Jeffrey A Tredup; Diane L Hollenbaugh
Novel diamide-based inhibitors of IMPDH.
Bioorganic & medicinal chemistry letters 2002;12(9):1323-6.
2002: Andrew B Adams; Nozomu Shirasugi; Megan M Durham; Elizabeth Strobert; Dan Anderson; Phyllis Rees; Shannon Cowan; Huaying Xu; Yelena Blinder; Michael Cheung; Diane L Hollenbaugh; Norma S Kenyon; Thomas C Pearson; Christian P Larsen
Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates.
Diabetes 2002;51(2):265-70.
2001: Alejandro Aruffo; Diane L Hollenbaugh
Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease.
Current opinion in immunology 2001;13(6):683-6.
1999: Mercedes Pérez-Melgosa; Diane L Hollenbaugh; Christopher B Wilson
Cutting edge: CD40 ligand is a limiting factor in the humoral response to T cell-dependent antigens.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1123-7.
1998: M Niimi; Thomas C Pearson; Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Alejandro Aruffo; Peter Linsley; E Thomas; K Campbell; W C Fanslow; R S Geha; Peter J Morris; Kathryn J Wood
The role of the CD40 pathway in alloantigen-induced hyporesponsiveness in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5331-7.
1998: K Seyama; Shigeaki Nonoyama; I Gangsaas; Diane L Hollenbaugh; H F Pabst; Alejandro Aruffo; Hans D Ochs
Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome.
Blood 1998;92(7):2421-34.
1998: C B Wilson; L J Embree; D Schowalter; R Albert; Alejandro Aruffo; Diane L Hollenbaugh; Peter Linsley; M A Kay
Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration.
Journal of virology 1998;72(9):7542-50.
1998: Eric T. Elwood; Christian P Larsen; Hong Rae Cho; Matthias Corbascio; S C Ritchie; DZ Alexander; Carol Tucker-Burden; Peter Linsley; Alejandro Aruffo; Diane L Hollenbaugh; K J Winn; Thomas C Pearson
Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.
Transplantation 1998;65(11):1422-8.
1998: Bharat D Damle; Diane L Hollenbaugh; J Timoszyk; Lee K Tay; S Kaul
Development of an immunoassay for BMS-191352, a single-chain immunotoxin, and its application to toxicokinetic studies.
Journal of immunoassay 1998;19(2-3):145-65.
1997: Qili Zhu; C Watanabe; T Liu; Diane L Hollenbaugh; R. Michael Blaese; Steven B Kanner; Alejandro Aruffo; Hans D Ochs
Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype.
Blood 1997;90(7):2680-9.
1997: David I Daikh; barbara finck; Peter Linsley; Diane L Hollenbaugh; David Wofsy
Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3104-8.
1997: Anne Marinier; Alain Martel; Jacques Banville; Carol Bachand; Roger Remillard; Philippe Lapointe; B Turmel; M Menard; W E Harte; John J Wright; Gordon Todderud; KM Tramposch; J Bajorath; Diane L Hollenbaugh; Alejandro Aruffo
Sulfated galactocerebrosides as potential antiinflammatory agents.
Journal of medicinal chemistry 1997;40(20):3234-47.
1997: Gordon Todderud; X Nair; D Lee; JG Alford; LB Davern; P Stanley; Carol Bachand; Philippe Lapointe; Anne Marinier; Alain Martel; M Menard; John J Wright; J Bajorath; Diane L Hollenbaugh; Alejandro Aruffo; KM Tramposch
BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1298-304.
1997: CH Clegg; J T Rulffes; Harald S Haugen; I H Hoggatt; Alejandro Aruffo; S K Durham; Andrew G Farr; Diane L Hollenbaugh
Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice.
International immunology 1997;9(8):1111-22.
1997: Mark A Kay; Leonard Meuse; A M Gown; Peter Linsley; Diane L Hollenbaugh; Alejandro Aruffo; Hans D Ochs; Christopher B Wilson
Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4686-91.
1997: Jeffrey A Ledbetter; Joseph A Francisco; Clay B Siegall; L K Gilliland; Diane L Hollenbaugh; Alejandro Aruffo; Anthony W Siadak; N Mischel-Petty; LS Grosmaire; M L Gordon; T J Brown; P Moran-Davis; Robert S Mittler; Peter Kiener; Steven G Nadler
Agonistic activity of a CD40-specific single-chain Fv constructed from the variable regions of mAb G28-5.
Critical reviews in immunology 1997;17(5-6):427-35.
1996: Ralf W Denfeld; Diane L Hollenbaugh; A Fehrenbach; Johannes M Weiss; A von Leoprechting; B Mai; U Voith; Erwin Schöpf; Alejandro Aruffo; Jan C Simon
CD40 is functionally expressed on human keratinocytes.
European journal of immunology 1996;26(10):2329-34.
1996: Christian P Larsen; Eric T. Elwood; DZ Alexander; S C Ritchie; R Hendrix; Carol Tucker-Burden; H R Cho; Alejandro Aruffo; Diane L Hollenbaugh; Peter Linsley; K J Winn; Thomas C Pearson
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.
Nature 1996;381(6581):434-8.
1996: Christian P Larsen; DZ Alexander; Diane L Hollenbaugh; Eric T. Elwood; S C Ritchie; Alejandro Aruffo; R Hendrix; Thomas C Pearson
CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway.
Transplantation 1996;61(1):4-9.
1995: Diane L Hollenbaugh; J Douthwright; V McDonald; Alejandro Aruffo
Cleavable CD40Ig fusion proteins and the binding to sgp39.
Journal of immunological methods 1995;188(1):1-7.
1995: L A Schubert; G King; Randy Q Cron; David B Lewis; Alejandro Aruffo; Diane L Hollenbaugh
The human gp39 promoter. Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation.
The Journal of biological chemistry 1995;270(50):29624-7.
1995: Peter Kiener; P Moran-Davis; B M Rankin; Alan F Wahl; Alejandro Aruffo; Diane L Hollenbaugh
Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4917-25.
1995: J Bajorath; J S Marken; N J Chalupny; T L Spoon; Anthony W Siadak; M Gordon; R J Noelle; Diane L Hollenbaugh; Alejandro Aruffo
Analysis of gp39/CD40 interactions using molecular models and site-directed mutagenesis.
Biochemistry 1995;34(31):9884-92.
1995: Diane L Hollenbaugh; N Mischel-Petty; C P Edwards; Jan C Simon; Ralf W Denfeld; Peter Kiener; Alejandro Aruffo
Expression of functional CD40 by vascular endothelial cells.
The Journal of experimental medicine 1995;182(1):33-40.
1995: Diane L Hollenbaugh; Alejandro Aruffo; Peter D Senter
Effects of chemical modification on the binding activities of P-selectin mutants.
Biochemistry 1995;34(16):5678-84.
1995: J Bajorath; N J Chalupny; J S Marken; Anthony W Siadak; J Skonier; M Gordon; Diane L Hollenbaugh; R J Noelle; H D Ochs; Alejandro Aruffo
Identification of residues on CD40 and its ligand which are critical for the receptor-ligand interaction.
Biochemistry 1995;34(6):1833-44.
1994: Jeffrey A Ledbetter; LS Grosmaire; Diane L Hollenbaugh; Alejandro Aruffo; Steven G Nadler
Agonistic and antagonistic properties of CD40 mAb G28-5 are dependent on binding valency.
Circulatory shock 1994;44(2):67-72.
1994: Hans D Ochs; Diane L Hollenbaugh; Alejandro Aruffo
The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency.
Seminars in immunology 1994;6(5):337-41.
1994: Diane L Hollenbaugh; L H Wu; H D Ochs; Shigeaki Nonoyama; LS Grosmaire; Jeffrey A Ledbetter; R J Noelle; H Hill; Alejandro Aruffo
The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1.
The Journal of clinical investigation 1994;94(2):616-22.
1994: Diane L Hollenbaugh; H D Ochs; R J Noelle; Jeffrey A Ledbetter; Alejandro Aruffo
The role of CD40 and its ligand in the regulation of the immune response.
Immunological reviews 1994;138():23-37.
1994: Hans D Ochs; Diane L Hollenbaugh; Alejandro Aruffo
The role of CD40L (gp39)/CD40 in T/B cell interaction and primary immunodeficiency.
Research in immunology 1994;145(3):210-5; discussion 244-9.
1994: J Bajorath; Diane L Hollenbaugh; G King; W Harte; D C Eustice; Richard P Darveau; Alejandro Aruffo
CD62/P-selectin binding sites for myeloid cells and sulfatides are overlapping.
Biochemistry 1994;33(6):1332-9.
1994: M Farrington; LS Grosmaire; Shigeaki Nonoyama; S H Fischer; Diane L Hollenbaugh; Jeffrey A Ledbetter; R J Noelle; Alejandro Aruffo; Hans D Ochs
CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(3):1099-103.
1994: Alejandro Aruffo; Diane L Hollenbaugh; L H Wu; H D Ochs
The molecular basis of X-linked agammaglobulinemia, hyper-IgM syndrome, and severe combined immunodeficiency in humans.
Current opinion in hematology 1994;1(1):12-8.
1993: Shigeaki Nonoyama; Diane L Hollenbaugh; Alejandro Aruffo; Jeffrey A Ledbetter; Hans D Ochs
B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells.
The Journal of experimental medicine 1993;178(3):1097-102.
1993: Robert Peach; Diane L Hollenbaugh; Ivan Stamenkovic; Alejandro Aruffo
Identification of hyaluronic acid binding sites in the extracellular domain of CD44.
The Journal of cell biology 1993;122(1):257-64.
1993: Diane L Hollenbaugh; J Bajorath; Ronald E Stenkamp; Alejandro Aruffo
Interaction of P-selectin (CD62) and its cellular ligand: analysis of critical residues.
Biochemistry 1993;32(12):2960-6.
1993: Alejandro Aruffo; M Farrington; Diane L Hollenbaugh; X Li; A Milatovich; Shigeaki Nonoyama; J Bajorath; LS Grosmaire; Ronald E Stenkamp; M Neubauer
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.
Cell 1993;72(2):291-300.
1992: Diane L Hollenbaugh; LS Grosmaire; C D Kullas; N J Chalupny; S Braesch-Andersen; R J Noelle; Ivan Stamenkovic; Jeffrey A Ledbetter; Alejandro Aruffo
The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.
The EMBO journal 1992;11(12):4313-21.
1992: N J Chalupny; Robert Peach; Diane L Hollenbaugh; Jeffrey A Ledbetter; Andrew G Farr; Alejandro Aruffo
T-cell activation molecule 4-1BB binds to extracellular matrix proteins.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(21):10360-4.
1992: Diane L Hollenbaugh; N J Chalupny; Alejandro Aruffo
Recombinant globulins: novel research tools and possible pharmaceuticals.
Current opinion in immunology 1992;4(2):216-9.