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Paul Hollingworth

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Jade Chapman; Amy Gerrish; Denise Harold; Paul Hollingworth; Peter Holmans; Dobril Ivanov; Michael C O'Donovan; Michael J Owen; Elliott Rees; Rebecca Sims; Alexandra Stretton; Julie Williams; George Kirov
A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
Petroula Proitsi; David C Rubinsztein; Hilkka Soininen; Stephen Todd; Magda Tsolaki; Bruno Velas; Julie Williams; Janet Johnson; Megan Pritchard; Carol Brayne; David Craig; Makrina Daniilidou; Frank Dudbridge; Michael Gill; Gillian Hamilton; Denise Harold; Paul Hollingworth; Iwona Kloszewska; Brian Lawlor; Kathryn Lord; Simon Lovestone; Michelle K Lupton; Belinda M Martin; Bernadette McGuinness; Patrizia Mecocci; Peter Passmore; John F Powell
Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation.
Petroula Proitsi; Suzanne J Reeves; David C Rubinsztein; Julie Williams; Nicola Archer; Carol Brayne; Michael Gill; Gillian Hamilton; Paul Hollingworth; Conrad Iyegbe; Brian Lawlor; Simon Lovestone; Michelle K Lupton; Belinda M Martin; Michael J Owen; John F Powell
Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia.

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2013: Jade Chapman; Amy Gerrish; Denise Harold; Paul Hollingworth; Peter Holmans; Dobril Ivanov; Michael C O'Donovan; Michael J Owen; Elliott Rees; Rebecca Sims; Alexandra Stretton; Julie Williams; George Kirov
A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.
Human molecular genetics 2013;22(4):816-24.
2012: Petroula Proitsi; David C Rubinsztein; Hilkka Soininen; Stephen Todd; Magda Tsolaki; Bruno Velas; Julie Williams; Janet Johnson; Megan Pritchard; Carol Brayne; David Craig; Makrina Daniilidou; Frank Dudbridge; Michael Gill; Gillian Hamilton; Denise Harold; Paul Hollingworth; Iwona Kloszewska; Brian Lawlor; Kathryn Lord; Simon Lovestone; Michelle K Lupton; Belinda M Martin; Bernadette McGuinness; Patrizia Mecocci; Peter Passmore; John F Powell
Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation.
Neurobiology of aging 2012;33(8):1843.e9-17.
2012: Petroula Proitsi; Suzanne J Reeves; David C Rubinsztein; Julie Williams; Nicola Archer; Carol Brayne; Michael Gill; Gillian Hamilton; Paul Hollingworth; Conrad Iyegbe; Brian Lawlor; Simon Lovestone; Michelle K Lupton; Belinda M Martin; Michael J Owen; John F Powell
Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia.
Neurobiology of aging 2012;33(4):791-803.
2011: Rebecca Sims; A David Smith; Alexandra Stretton; Charlene Thomas; Stephen Todd; Richard Abraham; Nicholas J Bass; Carol Brayne; Kristelle S Brown; Jade Chapman; John Collinge; David Craig; Kimberley Dowzell; Sarah Dwyer; Nick C Fox; Amy Gerrish; Michael Gill; Hugh Gurling; John Hardy; Denise Harold; Paul Hollingworth; Peter A Holmans; Clive Holmes; Dobril Ivanov; Janet A Johnston; Lesley Jones; Nicola Jones; Patrick G Kehoe; Brian Lawlor; Gill Livingston; Seth Love; Simon Lovestone; Michelle K Lupton; Aoibhinn Lynch; David Mann; Bernadette McGuiness; Andrew McQuillin; Simon Mead; Kevin Morgan; Valentina Moskvina; Michael O'Donovan; Michael J Owen; Jaspreet Singh Pahwa; Peter A Passmore; John Powell; Petroula Proitsi; Martin N Rossor; David C Rubinsztein; Julie Williams
No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2011;156B(7):764-71.
2011: Paul Hollingworth; Lesley Jones; Michael J Owen; Denise Harold; Julie Williams
Alzheimer's disease genetics: current knowledge and future challenges.
International journal of geriatric psychiatry 2011;26(8):793-802.
2011: Paul Hollingworth; Peter A Holmans; Clive Holmes; Nigel M Hooper; Michael Hüll; M Arfan Ikram; Dobril Ivanov; Frank Jessen; Karl-Heinz Jöckel; Lesley Jones; Nicola Jones; Palmi V Jonsson; Thorlakur Jonsson; John S K Kauwe; Patrick G Kehoe; Norman Klopp; Heike Kölsch; Johannes Kornhuber; Michael Krawczak; Jean-Charles Lambert; Mark Lathrop; Lenore J Launer; Brian Lawlor; Federico Licastro; Gill Livingston; Oscar L Lopez; Seth Love; Simon Lovestone; Michelle K Lupton; Aoibhinn Lynch; Wolfgang Maier; Michelangelo Mancuso; David Mann; Ignacio Mateo; Manuel Mayhaus; Kevin Mayo; Bernadette McGuinness; Andrew McQuillin; Simon Mead; Susanne Moebus; Kevin Morgan; John C Morris; Valentina Moskvina; Thomas W Mühleisen; Benedetta Nacmias; S Nicolhaus; Markus M Nöthen; Petra Nowotny; Michael O'Donovan; Michael J Owen; Jaspreet Singh Pahwa; V Shane Pankratz; Francesco Panza; Florence Pasquier; Peter A Passmore; Ronald C. Petersen; Paola Piccardi; Alberto Pilotto; Elisa Porcellini; John Powell; Petroula Proitsi; Alex Richards; Caterina Riehle; Matthias Riemenschneider; Martin N Rossor; David C Rubinsztein; Dan Rujescu; Eckart Rüther; Sigrid B Sando; Elio Scarpini; Stefan Schreiber; Britta Schürmann; Davide Seripa; Sudha Seshadri; Christopher E Shaw; Gabriele Siciliano; Rebecca Sims; Andrew B Singleton; Kristel Sleegers; A David Smith; Jon Snaedal; Hilkka Soininen; Vincenzo Solfrizzi; Sandro Sorbi; Hreinn Stefansson; Kari Stefansson; Stacy Steinberg; Alexandra Stretton; Charlene Thomas; Stephen Todd; Magda Tsolaki; Christophe Tzourio; Christine Van Broeckhoven; Hendrik van den Bussche; Cornelia M van Duijn; Emma R L C Vardy; Stefan Wagenpfeil; Donald Warden; H-Erich Wichmann; Caroline Widdowson; Gordon Wilcock; Jan O Aasly; Richard Abraham; Ammar Al-Chalabi; Annick Alpérovitch; Victoria Alvarez; Philippe Amouyel; Giorgio Annoni; Beatrice Arosio; Maria Barcikowska; Nicholas J Bass; Helen Beaumont; Claudine Berr; Karolien Bettens; Sigurbjörn Björnsson; Paolo Bosco; Paola Bossù; Carol Brayne; Monique Breteler; Alexis Brice; Kristelle S Brown; Maria J Bullido; Dominique Campion; Minerva M Carrasquillo; Jade Chapman; Vincent Chouraki; John Collinge; Onofre Combarros; Eliecer Coto; David Craig; Carlos Cruchaga; Jean-François Dartigues; Peter P De Deyn; Marc Delepine; Panagiotis Deloukas; Anita L DeStefano; Martin Dichgans; dennis dickson; Kimberley Dowzell; Sebastiaan Engelborghs; Jacques Epelbaum; Thomas M Feulner; Annette L Fitzpatrick; Nick C Fox; Ana Frank-Garcia; Patricia Friedrich; Lutz Frölich; Daniela Galimberti; John Gallacher; Benjamin Genier-Boley; Amy Gerrish; Ina Giegling; Michael Gill; Alison Goate; Neill R Graff-Radford; Rita Guerreiro; Hugh Gurling; Rhian Gwilliam; Harald Hampel; Marian L Hamshere; Didier Hannequin; Olivier Hanon; John Hardy; Denise Harold; Reiner Heun; Isabella Heuser; Mikko Hiltunen; Jens Wiltfang; Zbigniew K Wszolek; Steven G Younkin; Diana Zelenika; Julie Williams
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Nature genetics 2011;43(5):429-35.
2011: P Proitsi; G Hamilton; M Tsolaki; M Lupton; M Daniilidou; Paul Hollingworth; N Archer; C Foy; F Stylios; B McGuinness; S Todd; B Lawlor; M Gill; Carol Brayne; David C Rubinsztein; Michael J Owen; J Williams; David Craig; P Passmore; Simon Lovestone; John F Powell
A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD).
Neurobiology of aging 2011;32(3):434-42.
2011: Michelle K Lupton; Petroula Proitsi; Makrina Danillidou; Magda Tsolaki; Gillian Hamilton; Richard Wroe; Megan Pritchard; Kathryn Lord; Belinda M Martin; Iwona Kloszewska; Hilkka Soininen; Patrizia Mecocci; Bruno Vellas; Denise Harold; Paul Hollingworth; Simon Lovestone; John F Powell
Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.
PloS one 2011;6(2):e17298.
2011: Christiane Reitz; Rong Cheng; Ekaterina Rogaeva; Joseph H Lee; Shinya Tokuhiro; Fanggeng Zou; Karolien Bettens; Kristel Sleegers; Eng King Tan; Ryo Kimura; Nobuto Shibata; Heii Arai; M Ilyas Kamboh; Jonathan A Prince; Wolfgang Maier; Matthias Riemenschneider; Michael J Owen; Denise Harold; Paul Hollingworth; Elena Cellini; Sandro Sorbi; Benedetta Nacmias; Masatoshi Takeda; Margaret Pericak-Vance; Jonathan L Haines; Steven G Younkin; Julie Williams; Christine Van Broeckhoven; Lindsay A Farrer; Peter St George-Hyslop; Richard Mayeux
Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Archives of neurology 2011;68(1):99-106.
2010: Carlos Cruchaga; John S K Kauwe; Kevin Mayo; Noah Spiegel; Sarah Bertelsen; Petra Nowotny; Aarti R Shah; Richard Abraham; Paul Hollingworth; Denise Harold; Michael J Owen; Julie Williams; Simon Lovestone; Elaine R Peskind; Ge Li; James B Leverenz; Douglas Galasko; John C Morris; Anne M Fagan; David M Holtzman; Alison Goate
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease.
PLoS genetics 2010;6(9):.
2010: John S K Kauwe; Sarah Bertelsen; Kevin Mayo; Carlos Cruchaga; Richard Abraham; Paul Hollingworth; D Harold; Michael J Owen; Julie Williams; Simon Lovestone; John C Morris; Alison Goate
Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(4):955-9.
2010: Sudha Seshadri; Annette L Fitzpatrick; M Arfan Ikram; Anita L DeStefano; Vilmundur Gudnason; Merce Boada; Joshua C Bis; Albert Vernon Smith; Minerva M Carassquillo; Jean Charles Lambert; Denise Harold; Elisabeth M C Schrijvers; Reposo Ramirez-Lorca; Stephanie Debette; W T Longstreth; A Cecile J W Janssens; V Shane Pankratz; Jean-François Dartigues; Paul Hollingworth; Thor Aspelund; Isabel Hernandez; Alexa Beiser; Lewis H Kuller; Peter J Koudstaal; dennis dickson; Christophe Tzourio; Richard Abraham; Carmen Antunez; Yangchun Du; Jerome I Rotter; Yurii S Aulchenko; Tamara B Harris; Ronald C. Petersen; Claudine Berr; Michael J Owen; Jesus Lopez-Arrieta; Badri N Varadarajan; James T Becker; Fernando Rivadeneira; Michael A Nalls; Neill R Graff-Radford; Dominique Campion; Sanford Auerbach; Kenneth Rice; Albert Hofman; Palmi V Jonsson; Helena Schmidt; Mark Lathrop; Thomas H Mosley; Rhoda Au; Bruce M Psaty; Andre G Uitterlinden; Lindsay A Farrer; Thomas Lumley; Agustin Ruiz; Julie Williams; Philippe Amouyel; Steve G Younkin; Philip A Wolf; Lenore J Launer; Oscar L Lopez; Cornelia M van Duijn; Monique Breteler
Genome-wide analysis of genetic loci associated with Alzheimer disease.
JAMA : the journal of the American Medical Association 2010;303(18):1832-40.
2010: Lesley Jones; Peter A Holmans; Marian L Hamshere; Denise Harold; Valentina Moskvina; Dobril Ivanov; Andrew Pocklington; Richard Abraham; Paul Hollingworth; Rebecca Sims; Amy Gerrish; Jaspreet Singh Pahwa; Nicola Jones; Alexandra Stretton; Angharad R Morgan; Simon Lovestone; John Powell; Petroula Proitsi; Michelle K Lupton; Carol Brayne; David C Rubinsztein; Michael Gill; Brian Lawlor; Aoibhinn Lynch; Kevin Morgan; Kristelle S Brown; Peter A Passmore; David Craig; Bernadette McGuinness; Stephen Todd; Clive Holmes; David Mann; A David Smith; Seth Love; Patrick G Kehoe; Simon Mead; Nick C Fox; Martin N Rossor; John Collinge; Wolfgang Maier; Frank Jessen; Britta Schürmann; Reinhard Heun; Heike Kölsch; Hendrik van den Bussche; Isabella Heuser; Oliver Peters; Johannes Kornhuber; Jens Wiltfang; Martin Dichgans; Lutz Frölich; Harald Hampel; Michael Hüll; Dan Rujescu; Alison Goate; John S K Kauwe; Carlos Cruchaga; Petra Nowotny; John C Morris; Kevin Mayo; Gill Livingston; Nicholas J Bass; Hugh Gurling; Andrew McQuillin; Rhian Gwilliam; Panos Deloukas; Ammar Al-Chalabi; Christopher E Shaw; Andrew Singleton; Rita Guerreiro; Thomas W Mühleisen; Markus M Nöthen; Susanne Moebus; Karl-Heinz Jöckel; Norman Klopp; H-Erich Wichmann; Eckhard Rüther; Minerva M Carrasquillo; V Shane Pankratz; Steven G Younkin; John Hardy; Michael C O'Donovan; Michael J Owen; Julie Williams
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.
PloS one 2010;5(11):e13950.
2010: Michelle K Lupton; Daniel Stahl; Nicola Archer; Catherine Foy; Michaela Poppe; Simon Lovestone; Paul Hollingworth; Julie Williams; Michael J Owen; Kimberley Dowzell; Richard Abraham; Rebecca Sims; Carol Brayne; David C Rubinsztein; Michael Gill; Brian A Lawlor; Aoibhinn Lynch; John F Powell
Education, occupation and retirement age effects on the age of onset of Alzheimer's disease.
International journal of geriatric psychiatry 2010;25(1):30-6.
2009: Richard Abraham; Rebecca Sims; Liam Carroll; Paul Hollingworth; Michael C O'Donovan; Julie Williams; Michael J Owen
An association study of common variation at the MAPT locus with late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(8):1152-5.
2009: Denise Harold; Richard Abraham; Paul Hollingworth; Rebecca Sims; Amy Gerrish; Marian L Hamshere; Jaspreet Singh Pahwa; Valentina Moskvina; Kimberley Dowzell; Amy Williams; Nicola Jones; Charlene Thomas; Alexandra Stretton; Angharad R Morgan; Simon Lovestone; John Powell; Petroula Proitsi; Michelle K Lupton; Carol Brayne; David C Rubinsztein; Michael Gill; Brian Lawlor; Aoibhinn Lynch; Kevin Morgan; Kristelle S Brown; Peter A Passmore; David Craig; Bernadette McGuinness; Stephen Todd; Clive Holmes; D M A Mann; A David Smith; Seth Love; Patrick G Kehoe; John Hardy; Simon Mead; Nick C Fox; Martin N Rossor; John Collinge; Wolfgang Maier; Frank Jessen; Britta Schürmann; Hendrik van den Bussche; Isabella Heuser; Johannes Kornhuber; Jens Wiltfang; Martin Dichgans; Lutz Froelich; Harald Hampel; Michael Hüll; Dan Rujescu; Alison Goate; John S K Kauwe; Carlos Cruchaga; Petra Nowotny; John C Morris; Kevin Mayo; Kristel Sleegers; Karolien Bettens; Sebastiaan Engelborghs; Peter P De Deyn; Christine Van Broeckhoven; Gillian Livingston; Nicholas J Bass; Hugh Gurling; Andrew McQuillin; Rhian Gwilliam; Panagiotis Deloukas; Ammar Al-Chalabi; Christopher Shaw; Magda Tsolaki; Andrew Singleton; Rita Guerreiro; Thomas W Mühleisen; Markus M Nöthen; Susanne Moebus; Karl-Heinz Jöckel; Norman Klopp; H-Erich Wichmann; Minerva M Carrasquillo; V Shane Pankratz; Steven G Younkin; Peter A Holmans; Michael O'Donovan; Michael J Owen; Julie Williams
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Nature genetics 2009;41(10):1088-93.
2009: R Sims; Paul Hollingworth; Valentina Moskvina; K Dowzell; Michael C O'Donovan; John Powell; Simon Lovestone; Carol Brayne; David C Rubinsztein; Michael J Owen; Julie Williams; Richard Abraham
Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease.
Neuroscience letters 2009;461(1):54-9.
2009: A R Morgan; Paul Hollingworth; Richard Abraham; Simon Lovestone; Carol Brayne; David C Rubinsztein; A Lynch; Brian A Lawlor; Michael Gill; Michael C O'Donovan; Michael J Owen; Julie Williams
Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(1):61-4.
2008: A R Morgan; Gillian Hamilton; Darko Turic; Luke Jehu; Denise Harold; Richard Abraham; Paul Hollingworth; Valentina Moskvina; Carol Brayne; David C Rubinsztein; A Lynch; Brian A Lawlor; Michael Gill; Michael O'Donovan; John Powell; Simon Lovestone; Julie Williams; Michael J Owen
Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(6):727-31.
2008: Elin S Blom; Peter Holmans; Sampath Arepalli; Omanma Adighibe; Marian L Hamshere; Margaret Gatz; Nancy L Pedersen; A L Mina Bergem; Michael J Owen; Paul Hollingworth; Alison Goate; Julie Williams; Lars Lannfelt; John Hardy; Fabienne Wavrant-De Vrièze; Anna Glaser
Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008;147B(6):778-83.
2008: Yonghong Li; Andrew Grupe; Charles Rowland; Peter Holmans; Ricardo Segurado; Richard Abraham; Lesley Jones; Joseph J Catanese; David Ross; Kevin Mayo; Maribel Martinez; Paul Hollingworth; Alison Goate; Nigel J Cairns; Brad A Racette; Joel S Perlmutter; Michael C O'Donovan; John C Morris; Carol Brayne; David C Rubinsztein; Simon Lovestone; Leon J Thal; Michael J Owen; Julie Williams
Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.
Human molecular genetics 2008;17(5):759-67.
2008: Richard Abraham; Valentina Moskvina; Rebecca Sims; Paul Hollingworth; Angharad Morgan; Lyudmila Georgieva; Kimberley Dowzell; Sven Cichon; Axel M Hillmer; Michael C O'Donovan; Julie Williams; Michael J Owen; George Kirov
A genome-wide association study for late-onset Alzheimer's disease using DNA pooling.
BMC medical genomics 2008;1():44.
2008: Hao Li; Sally Wetten; Li Li; Pamela L St Jean; Ruchi Upmanyu; Linda Surh; David Hosford; Michael R Barnes; James David Briley; Michael Borrie; Natalie Coletta; Richard Delisle; Daniella Dhalla; Margaret G Ehm; Howard H Feldman; Luis Fornazzari; S Gauthier; Neil Goodgame; Danilo Guzman; Sandra Hammond; Paul Hollingworth; Ging-Yuek Hsiung; Joan Johnson; Devon D Kelly; Ron Keren; Andrew Kertesz; Karen S King; Simon Lovestone; Inge Loy-English; Paul Matthews; Michael J Owen; Mary Plumpton; William Pryse-Phillips; Rab Prinjha; Jill C Richardson; Ann M Saunders; Andrew J Slater; Peter St George-Hyslop; Sandra W Stinnett; Jina Swartz; Rachel L Taylor; John Wherrett; Julie Williams; David P Yarnall; Rachel A Gibson; Michael C Irizarry; Lefkos T Middleton; Allen D Roses
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
Archives of neurology 2008;65(1):45-53.
2007: Catherine M L Foy; Helen Nicholas; Paul Hollingworth; Harry Boothby; Julie Willams; Richard Brown; Safa Al-Sarraj; Simon Lovestone
Diagnosing Alzheimer's disease--non-clinicians and computerised algorithms together are as accurate as the best clinical practice.
International journal of geriatric psychiatry 2007;22(11):1154-63.
2007: Paul Hollingworth; Marian Hamshere; Peter Holmans; Michael C O'Donovan; Rebecca Sims; John Powell; Simon Lovestone; Amanda Myers; FW DeVrieze; John Hardy; Alison Goate; Michael J Owen; Julie Williams
Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(7):841-8.
2007: A R Morgan; Darko Turic; Luke Jehu; Gillian Hamilton; Paul Hollingworth; Valentina Moskvina; Lesley Jones; Simon Lovestone; Carol Brayne; David C Rubinsztein; Brian A Lawlor; Michael Gill; Michael C O'Donovan; Michael J Owen; Julie Williams
Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(6):762-70.
2007: Denise Harold; Luke Jehu; Darko Turic; Paul Hollingworth; Pamela Moore; P Summerhayes; Valentina Moskvina; Catherine Foy; Nicola Archer; B A Hamilton; Simon Lovestone; John Powell; Carol Brayne; David C Rubinsztein; Lesley Jones; Michael C O'Donovan; Michael J Owen; Julie Williams
Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(4):448-52.
2007: Andrew Grupe; Richard Abraham; Yonghong Li; Charles Rowland; Paul Hollingworth; Angharad Morgan; Luke Jehu; Ricardo Segurado; David Stone; Eric Schadt; Maha Karnoub; Petra Nowotny; Kristina Tacey; Joseph J Catanese; John J Sninsky; Carol Brayne; David C Rubinsztein; Michael Gill; Brian A Lawlor; Simon Lovestone; Peter Holmans; Michael O'Donovan; John C Morris; Leon J Thal; Alison Goate; Michael J Owen; Julie Williams
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.
Human molecular genetics 2007;16(8):865-73.
2006: Paul Hollingworth; Marian Hamshere; Valentina Moskvina; Kimberley Dowzell; Pamela J Moore; Catherine Foy; Nicola Archer; Aoibhinn Lynch; Simon Lovestone; Carol Brayne; David C Rubinsztein; Brian A Lawlor; Mike Gill; Michael J Owen; Julie Williams
Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease.
Journal of the American Geriatrics Society 2006;54(9):1348-54.
2006: Yonghong Li; Andrew Grupe; Charles Rowland; Petra Nowotny; John S K Kauwe; Scott Smemo; Anthony L Hinrichs; Kristina Tacey; Timothy A Toombs; Shirley Kwok; Joseph J Catanese; Thomas J White; Taylor J Maxwell; Paul Hollingworth; Richard Abraham; David C Rubinsztein; Carol Brayne; Fabienne Wavrant-De Vrièze; John Hardy; Michael O'Donovan; Simon Lovestone; John C Morris; Leon J Thal; Michael J Owen; Julie Williams; Alison Goate
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.
Human molecular genetics 2006;15(17):2560-8.
2006: Gillian Hamilton; Farzana Samedi; Jo Knight; Nicola Archer; Catherine Foy; Sarah Walter; Darko Turic; Luke Jehu; Pamela Moore; Paul Hollingworth; Michael C O'Donovan; Julie Williams; Michael J Owen; Simon Lovestone; John F Powell
Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease.
Neuroscience letters 2006;401(1-2):77-80.
2006: Denise Harold; Stuart Macgregor; Cathryn E Patterson; Paul Hollingworth; Pamela Moore; Michael J Owen; Julie Williams; Michael O'Donovan; Peter Passmore; Stephen McIlroy; Lesley Jones
A single nucleotide polymorphism in CHAT influences response to acetylcholinesterase inhibitors in Alzheimer's disease.
Pharmacogenetics and genomics 2006;16(2):75-7.
2006: Andrew Grupe; Yonghong Li; Charles Rowland; Petra Nowotny; Anthony L Hinrichs; Scott Smemo; John S K Kauwe; Taylor J Maxwell; Sara Cherny; Lisa Doil; Kristina Tacey; Ryan van Luchene; Amanda Myers; Fabienne Wavrant-De Vrièze; Mona Kaleem; Paul Hollingworth; Luke Jehu; Catherine Foy; Nicola Archer; Gillian Hamilton; Peter Holmans; Chris M Morris; Joseph Catanese; John Sninsky; Thomas J White; John Powell; John Hardy; Michael O'Donovan; Simon Lovestone; Lesley Jones; John C Morris; Leon J Thal; Michael J Owen; Julie Williams; Alison Goate
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
American journal of human genetics 2006;78(1):78-88.
2006: Scott Smemo; Petra Nowotny; Anthony L Hinrichs; John S K Kauwe; Sara Cherny; Katherine Erickson; Amanda Myers; Mona Kaleem; Lauren Marlowe; Alison M Gibson; Paul Hollingworth; Michael C O'Donovan; Christopher M Morris; Peter Holmans; Simon Lovestone; John C Morris; Leon J Thal; Yonghong Li; Andrew Grupe; John Hardy; Michael J Owen; Julie Williams; Alison Goate
Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.
Annals of neurology 2006;59(1):21-6.
2005: Petra Nowotny; Anthony L Hinrichs; Scott Smemo; John S K Kauwe; Taylor Maxwell; Peter Holmans; Marian Hamshere; Darko Turic; Luke Jehu; Paul Hollingworth; Pamela Moore; Leslie Bryden; Amanda Myers; Lisa M Doil; Kristina M Tacey; Alison M Gibson; Ian G McKeith; Robert H Perry; Christopher M Morris; Leon J Thal; John C Morris; Michael C O'Donovan; Simon Lovestone; Andrew Grupe; John Hardy; Michael J Owen; Julie Williams; Alison Goate
Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;136B(1):62-8.
2005: Peter Holmans; Marian Hamshere; Paul Hollingworth; Frances Rice; Nigel Tunstall; Sue Jones; Pamela Moore; Fabienne Wavrant DeVrieze; Amanda Myers; Richard Crook; Danielle Compton; Helen Marshall; David Meyer; Shantia Shears; Jeremy Booth; Dzanan Ramic; Nigel Williams; Nadine Norton; Richard Abraham; Pat Kehoe; Hywel Williams; Varuni Rudrasingham; Michael O'Donovan; Lesley Jones; John Hardy; Alison Goate; Simon Lovestone; Michael J Owen; Julie Williams
Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;135B(1):24-32.
2005: Yonghong Li; Paul Hollingworth; Pamela Moore; Catherine Foy; Nicola Archer; John Powell; Petra Nowotny; Peter Holmans; Michael O'Donovan; Kristina Tacey; Lisa Doil; Ryan van Luchene; Veronica Garcia; Charles Rowland; Kit Lau; Joseph Cantanese; John J Sninsky; John Hardy; Leon J Thal; John C Morris; Alison Goate; Simon Lovestone; Michael J Owen; Julie Williams; Andrew Grupe
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.
Human mutation 2005;25(3):270-7.
2005: Lynnette J Cook; Luk W Ho; Lin Wang; Edith Terrenoire; Carol Brayne; John Grimley Evans; John H Xuereb; Nigel J Cairns; Darko Turic; Paul Hollingworth; Pamela J Moore; Luke Jehu; Nicola Archer; Sarah Walter; Catherine Foy; Amanda Edmondson; John Powell; Simon Lovestone; Julie Williams; David C Rubinsztein
Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2005;132B(1):5-8.
2004: Lynnette J Cook; Luk W Ho; Alison E Taylor; Carol Brayne; John Grimley Evans; John H Xuereb; Nigel J Cairns; Antonia Pritchard; Helen Lemmon; D M A Mann; David St Clair; Darko Turic; Paul Hollingworth; Pamela J Moore; Luke Jehu; Nicola Archer; Sarah Walter; Catherine Foy; Amanda Edmondson; John Powell; Simon Lovestone; Michael J Owen; Julie Williams; Corinne Lendon; David C Rubinsztein
Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease.
Neuroscience letters 2004;358(2):142-6.
2004: Victoria Busby; Steven Goossens; Petra Nowotny; Gillian Hamilton; Scott Smemo; Denise Harold; Dragana Turic; Luke Jehu; Amanda Myers; Meredith Womick; Daniel Woo; Danielle Compton; Lisa M Doil; Kristina M Tacey; Kit F Lau; Safa Al-Saraj; Richard Killick; Stuart Pickering-Brown; Pamela Moore; Paul Hollingworth; Nicola Archer; Catherine Foy; Sarah Walter; Corrine Lendon; Takeshi Iwatsubo; John C Morris; Joanne Norton; D M A Mann; Barbara Janssens; John Hardy; Michael O'Donovan; Lesley Jones; Julie Williams; Peter Holmans; Michael J Owen; Andrew Grupe; John Powell; Jolanda van Hengel; Alison Goate; Frans Van Roy; Simon Lovestone
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease.
Neuromolecular medicine 2004;5(2):133-46.
2003: Denise Harold; Tim Peirce; Valentina Moskvina; Amanda Myers; Susan Jones; Paul Hollingworth; Pamela Moore; Simon Lovestone; John Powell; Catherine Foy; Nicola Archer; Sarah Walter; Amanda Edmonson; Stephen McIlroy; David Craig; Peter Passmore; Alison Goate; John Hardy; Michael O'Donovan; Julie Williams; Malcolm Liddell; Michael J Owen; Lesley Jones
Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease.
Human genetics 2003;113(3):258-67.