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Graham Holloway

Research Profile

Anatomy

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Oxidation-Reduction

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Publications

TOP 3
Brennan K Smith; Lawrence L Spriet; Brendon J Gurd; George J F Heigenhauser; James S Lally; Amy C Maher; Kazutaka Mukai; Graham P Holloway
AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle.
James S V Lally; Amy C Maher; Sarthak Matravadia; Christopher G R Perry; Renée Ventura-Clapier; Eric A F Herbst; Graham P Holloway
Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics.
Brennan K Smith; Jeffrey C Smith; David C Wright; Timothy R Koves; Deborah M Muoio; P Darrell Neufer; Christopher G R Perry; Graham P Holloway
Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.

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All Publications

2013: Brennan K Smith; Lawrence L Spriet; Brendon J Gurd; George J F Heigenhauser; James S Lally; Amy C Maher; Kazutaka Mukai; Graham P Holloway
AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle.
The Journal of physiology 2013;591(Pt 6):1551-61.
2013: James S V Lally; Amy C Maher; Sarthak Matravadia; Christopher G R Perry; Renée Ventura-Clapier; Eric A F Herbst; Graham P Holloway
Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics.
PloS one 2013;8(1):e55660.
2012: Brennan K Smith; Jeffrey C Smith; David C Wright; Timothy R Koves; Deborah M Muoio; P Darrell Neufer; Christopher G R Perry; Graham P Holloway
Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates.
The Biochemical journal 2012;448(1):13-20.
2012: Brennan K Smith; Arend Bonen; Graham P Holloway
A dual mechanism of action for skeletal muscle FAT/CD36 during exercise.
Exercise and sport sciences reviews 2012;40(4):211-7.
2012: Swati S Jain; Joost J F P Luiken; Laelie A Snook; Debbie C Thurmond; Jan F C Glatz; Graham P Holloway; Arend Bonen
Munc18c provides stimulus-selective regulation of GLUT4 but not fatty acid transporter trafficking in skeletal muscle.
FEBS letters 2012;586(16):2428-35.
2012: Jay T McFarlan; Ryan A Sayer; Brennan K Smith; Laelie A Snook; A Russell Tupling; Yuko Yoshida; Adrian Chabowski; Jan F C Glatz; Xiao-Xia Han; Graham P Holloway; Swati S Jain; James Lally; Joost J F P Luiken; Arend Bonen
In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidation.
The Journal of biological chemistry 2012;287(28):23502-16.
2012: Jamie S V Lally; Joost J F P Luiken; J McFarlan; Laelie A Snook; Jan F C Glatz; Xiao-Xia Han; Graham P Holloway; S S Jain; Arend Bonen
Caffeine-stimulated fatty acid oxidation is blunted in CD36 null mice.
Acta physiologica (Oxford, England) 2012;205(1):71-81.
2012: Graham P Holloway; Val Andrew Fajardo; Lauren McMeekin; Paul J LeBlanc
Unsaturation of mitochondrial membrane lipids is related to palmitate oxidation in subsarcolemmal and intermyofibrillar mitochondria.
The Journal of membrane biology 2012;245(4):165-76.
2011: Brennan K Smith; Renée Ventura-Clapier; Arend Bonen; Aaron Dam; Swati S Jain; Joe Quadrilatero; Stéphanie Rimbaud; Graham P Holloway
FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation.
The Biochemical journal 2011;437(1):125-34.
2011: Hakam Alkhateeb; Graham P Holloway; Arend Bonen
Skeletal muscle fatty acid oxidation is not directly associated with AMPK or ACC2 phosphorylation.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2011;36(3):361-7.
2011: Graham P Holloway; C J Chou; Jamie S V Lally; Trent Stellingwerff; A C Maher; O Gavrilova; M Haluzik; Hakam Alkhateeb; M L Reitman; Arend Bonen
Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance.
Diabetologia 2011;54(6):1457-67.
2011: Graham P Holloway; Laelie A Snook; Robert J Harris; Jan F C Glatz; Joost J F P Luiken; Arend Bonen
In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation.
The Journal of physiology 2011;589(Pt 1):169-80.
2010: Brennan K Smith; Graham P Holloway; Sandra Reza-Lopez; Stanley M Jeram; Jing X Kang; David W L Ma
A decreased n-6/n-3 ratio in the fat-1 mouse is associated with improved glucose tolerance.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2010;35(5):699-706.
2010: Carley Benton; Graham P Holloway; Xiao-Xia Han; Y Yoshida; Laelie A Snook; Jamie S V Lally; Jan F C Glatz; Joost J F P Luiken; Adrian Chabowski; Arend Bonen
Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats.
Diabetologia 2010;53(9):2008-19.
2010: Jason L Talanian; Graham P Holloway; Laelie A Snook; George J F Heigenhauser; Arend Bonen; Lawrence L Spriet
Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2010;299(2):E180-8.
2010: Graham P Holloway; Brendon J Gurd; Laelie A Snook; Jamie Lally; Arend Bonen
Compensatory increases in nuclear PGC1alpha protein are primarily associated with subsarcolemmal mitochondrial adaptations in ZDF rats.
Diabetes 2010;59(4):819-28.
2009: Arend Bonen; Graham P Holloway; Narendra Tandon; Xiao-Xia Han; Jay McFarlan; Jan F C Glatz; Joost J F P Luiken
Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(4):R1202-12.
2009: Graham P Holloway; Swati S Jain; Veronic Bezaire; Xiao-Xia Han; Jan F C Glatz; Joost J F P Luiken; Mary-Ellen Harper; Arend Bonen
FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle.
American journal of physiology. Regulatory, integrative and comparative physiology 2009;297(4):R960-7.
2009: Graham P Holloway
Mitochondrial function and dysfunction in exercise and insulin resistance.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2009;34(3):440-6.
2009: Brendon J Gurd; Yuko Yoshida; James Lally; Graham P Holloway; Arend Bonen
The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis.
The Journal of physiology 2009;587(Pt 8):1817-28.
2009: Graham P Holloway; Carley Benton; Kerry L Mullen; Yuko Yoshida; Laelie A Snook; Xiao-Xia Han; Jan F C Glatz; Joost J F P Luiken; James Lally; David J Dyck; Arend Bonen
In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation.
American journal of physiology. Endocrinology and metabolism 2009;296(4):E738-47.
2009: Graham P Holloway; Arend Bonen; Lawrence L Spriet
Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals.
The American journal of clinical nutrition 2009;89(1):455S-62S.
2008: Graham P Holloway; Joost J F P Luiken; Jan F C Glatz; Lawrence L Spriet; Arend Bonen
Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview.
Acta physiologica (Oxford, England) 2008;194(4):293-309.
2008: Carley Benton; Graham P Holloway; Shannon E Campbell; Yuko Yoshida; Narendra Tandon; Jan F C Glatz; Joost J F P Luiken; Lawrence L Spriet; Arend Bonen
Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria.
The Journal of physiology 2008;586(6):1755-66.
2008: Carley Benton; James G Nickerson; James Lally; Xiao-Xia Han; Graham P Holloway; Jan F C Glatz; Joost J F P Luiken; Terry E Graham; John J Heikkila; Arend Bonen
Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria.
The Journal of biological chemistry 2008;283(7):4228-40.
2008: Howard J Green; Todd A Duhamel; Graham P Holloway; JW Moule; Don Ranney; A Russell Tupling; J Ouyang
Rapid upregulation of GLUT-4 and MCT-4 expression during 16 h of heavy intermittent cycle exercise.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(2):R594-600.
2007: James G Nickerson; Iman Momken; Carley Benton; Jamie S V Lally; Graham P Holloway; Xiao-Xia Han; Jan F C Glatz; Adrian Chabowski; Joost J F P Luiken; Arend Bonen
Protein-mediated fatty acid uptake: regulation by contraction, AMP-activated protein kinase, and endocrine signals.
Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme 2007;32(5):865-73.
2007: Yuko Yoshida; Graham P Holloway; Vladimir Ljubicic; Hideo Hatta; Lawrence L Spriet; David A Hood; Arend Bonen
Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle.
The Journal of physiology 2007;582(Pt 3):1317-35.
2007: Graham P Holloway; Jamie S V Lally; James G Nickerson; Hakam Alkhateeb; Laelie A Snook; George J F Heigenhauser; Jorge Calles-Escandon; Jan F C Glatz; Joost J F P Luiken; Lawrence L Spriet; Arend Bonen
Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle.
The Journal of physiology 2007;582(Pt 1):393-405.
2007: Graham P Holloway; A Brianne Thrush; George J F Heigenhauser; Narendra Tandon; David J Dyck; Arend Bonen; Lawrence L Spriet
Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1782-9.
2006: Graham P Holloway; Veronic Bezaire; George J F Heigenhauser; Narendra Tandon; Jan F C Glatz; Joost J F P Luiken; Arend Bonen; Lawrence L Spriet
Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise.
The Journal of physiology 2006;571(Pt 1):201-10.