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Jeff Holly
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30
Perks, Claire
17
Stewart, Claire
16
Dunger, David
16
Gunnell, David
14
Cotterill, AM
14
Wass, J A H
11
Lønning, Per Eystein
11
Helle, Svein Inge
10
Newcomb, Paul
9
Mason, Helen
9
Cheetham, TD
7
Chard, T
7
Franks, Stephen
7
Martin, Richard
7
mcCaig, catherine
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All Publications
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2009: Uzoh Christopher C; Perks Claire M; Bahl Amit; Holly Jeff M P; Sugiono Marto; Persad Raj A
PTEN-mediated pathways and their association with treatment-resistant prostate cancer.
BJU international 2009;104(4):556-61.
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2009: Rowlands Mari-Anne; Gunnell David; Harris Ross; Vatten Lars J; Holly Jeff M P; Martin Richard M
Circulating insulin-like growth factor peptides and prostate cancer risk: a systematic review and meta-analysis.
International journal of cancer. Journal international du cancer 2009;124(10):2416-29.
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2009: Whitley Elise; Martin Richard M; Smith George Davey; Holly Jeff M P; Gunnell David
Childhood stature and adult cancer risk: the Boyd Orr cohort.
Cancer causes & control : CCC 2009;20(2):243-51.
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2009: Thomas Francis; Patel Suril; Holly Jeff M P; Persad Raj; Bahl Amit; Perks Claire M
Dihydrotestosterone sensitises LNCaP cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor.
The Prostate 2009;69(2):219-24.
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2008: Perks Claire M; Holly Jeff M P
IGF binding proteins (IGFBPs) and regulation of breast cancer biology.
Journal of mammary gland biology and neoplasia 2008;13(4):455-69.
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2008: Whitley Elise; Gunnell David; Davey Smith George; Holly Jeff M P; Martin Richard M
Childhood circumstances and anthropometry: the Boyd Orr cohort.
Annals of human biology 2008;35(5):518-34.
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2008: Rosendahl Ann H; Holly Jeff M P; Celander Mona; Forsberg Göran
Systemic IGF-I administration stimulates the in vivo growth of early, but not advanced, renal cell carcinoma.
International journal of cancer. Journal international du cancer 2008;123(6):1286-91.
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2008: Holly Jeff M P; Perks Claire M
Cancer as an endocrine problem.
Best practice & research. Clinical endocrinology & metabolism 2008;22(4):539-50.
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2008: Holly Jeff M P
Endocrine and metabolic determinants of cancer risk. Preface.
Best practice & research. Clinical endocrinology & metabolism 2008;22(4):vii-viii.
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2008: Martin Richard M; Gunnell David; Whitley Elise; Nicolaides Andrew; Griffin Maura; Georgiou Niki; Davey Smith George; Ebrahim Shah; Holly Jeff M P
Associations of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein (IGFBP)-2 and IGFBP-3 with ultrasound measures of atherosclerosis and plaque stability in an older adult population.
The Journal of clinical endocrinology and metabolism 2008;93(4):1331-8.
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2007: Sabin Matthew A; De Hora Mark; Holly Jeff M P; Hunt Linda P; Ford Anna L; Williams Simon R; Baker Julien S; Retallick Christopher J; Crowne Elizabeth C; Shield Julian P H
Fasting nonesterified fatty acid profiles in childhood and their relationship with adiposity, insulin sensitivity, and lipid levels.
Pediatrics 2007;120(6):e1426-33.
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2007: Martin R M; Holly J M P; Middleton N; Davey Smith G; Gunnell D
Childhood diet and insulin-like growth factors in adulthood: 65-year follow-up of the Boyd Orr Cohort.
European journal of clinical nutrition 2007;61(11):1281-92.
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2007: Sabin Matthew A; Crowne Elizabeth C; Stewart Claire E; Hunt Linda P; Turner Stephen J; Welsh Gavin I; Grohmann Malcolm J; Holly Jeff M; Shield Julian P
Depot-specific effects of fatty acids on lipid accumulation in children's adipocytes.
Biochemical and biophysical research communications 2007;361(2):356-61.
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2007: Sabin Matthew A; Stewart Claire E H; Crowne Elizabeth C; Turner Stephen J; Hunt Linda P; Welsh Gavin I; Grohmann Malcolm J; Holly Jeff M P; Shield Julian P H
Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid.
Journal of cellular physiology 2007;211(1):244-52.
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2007: Gunnell D; Lewis S; Wilkinson J; Georgieva L; Davey G Smith; Day I N M; Holly J M P; O'Donovan M C; Owen M J; Kirov G; Zammit S
IGF1, growth pathway polymorphisms and schizophrenia: a pooling study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007;144B(1):117-20.
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2006: Martin Richard M; Holly Jeff M P; Davey Smith George; Gunnell David
Associations of adiposity from childhood into adulthood with insulin resistance and the insulin-like growth factor system: 65-year follow-up of the Boyd Orr Cohort.
The Journal of clinical endocrinology and metabolism 2006;91(9):3287-95.
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2006: Burrows C; Holly J M P; Laurence N J; Vernon E G; Carter J V; Clark M A; McIntosh J; McCaig C; Winters Z E; Perks C M
Insulin-like growth factor binding protein 3 has opposing actions on malignant and nonmalignant breast epithelial cells that are each reversible and dependent upon cholesterol-stabilized integrin receptor complexes.
Endocrinology 2006;147(7):3484-500.
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2006: Wong Chris K M; Lai Teresa; Holly Jeffrey M P; Wheeler Malcolm H; Stewart Claire E H; Farndon John R
The effects of retinoic acid on the insulin-like growth factor axis in primary tissue culture from hyperparathyroidism.
World journal of surgery 2006;30(5):714-20.
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2006: Bray Isabelle; Gunnell David; Holly Jeff M P; Middleton Nicos; Davey Smith George; Martin Richard M
Associations of childhood and adulthood height and the components of height with insulin-like growth factor levels in adulthood: a 65-year follow-up of the Boyd Orr cohort.
The Journal of clinical endocrinology and metabolism 2006;91(4):1382-9.
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2006: dos Santos Silva Isabel; Johnson Nichola; De Stavola Bianca; Torres-Mejía Gabriela; Fletcher Olivia; Allen Diane S; Allen Naomi E; Key Timothy J; Fentiman Ian S; Holly Jeff M P; Peto Julian
The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(3):449-55.
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2006: Wong C K M; Lai T; Holly J M P; Wheeler M H; Stewart C E H; Farndon J R
Insulin-like growth factors (IGF) I and II utilize different calcium signaling pathways in a primary human parathyroid cell culture model.
World journal of surgery 2006;30(3):333-45.
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2006: Sabin M A; Ford A L; Holly J M P; Hunt L P; Crowne E C; Shield J P H
Characterisation of morbidity in a UK, hospital based, obesity clinic.
Archives of disease in childhood 2006;91(2):126-30.
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2006: Sabin Matthew A; Holly Jeff M P; Shield Julian P H; Turner Stephen J; Grohmann Malcolm J; Stewart Claire E H; Crowne Elizabeth C
Mature subcutaneous and visceral adipocyte concentrations of adiponectin are highly correlated in prepubertal children and inversely related to body mass index standard deviation score.
The Journal of clinical endocrinology and metabolism 2006;91(1):332-5.
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2005: Gunnell David; Miller Laura L; Rogers Imogen; Holly Jeff M P;
Association of insulin-like growth factor I and insulin-like growth factor-binding protein-3 with intelligence quotient among 8- to 9-year-old children in the Avon Longitudinal Study of Parents and Children.
Pediatrics 2005;116(5):e681-6.
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2005: Clark Martin A; Perks Claire M; Winters Zoë E; Holly Jeff M P
DNA damage uncouples the mitogenic response to IGF-I in MCF-7 malignant breast cancer cells by switching the roles of PI3 kinase and p21WAF1/Cip1.
International journal of cancer. Journal international du cancer 2005;116(4):506-13.
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2005: Martin Richard M; Ebrahim Shah; Griffin Maura; Davey Smith George; Nicolaides Andrew N; Georgiou Niki; Watson Simone; Frankel Stephen; Holly Jeff M P; Gunnell David
Breastfeeding and atherosclerosis: intima-media thickness and plaques at 65-year follow-up of the Boyd Orr cohort.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(7):1482-8.
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2005: Martin Richard M; Holly Jeff M P; Smith George Davey; Ness Andrew R; Emmett Pauline; Rogers Imogen; Gunnell David;
Could associations between breastfeeding and insulin-like growth factors underlie associations of breastfeeding with adult chronic disease? The Avon Longitudinal Study of Parents and Children.
Clinical endocrinology 2005;62(6):728-37.
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2005: Allen N E; Roddam A W; Allen D S; Fentiman I S; Dos Santos Silva I; Peto J; Holly J M P; Key T J
A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk.
British journal of cancer 2005;92(7):1283-7.
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2005: Rogers Imogen S; Gunnell David; Emmett Pauline M; Glynn Louise R; Dunger David B; Holly Jeff M
Cross-sectional associations of diet and insulin-like growth factor levels in 7- to 8-year-old children.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(1):204-12.
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2005: Fletcher Olivia; Gibson Lorna; Johnson Nichola; Altmann Dan R; Holly Jeffrey M P; Ashworth Alan; Peto Julian; Silva Isabel Dos Santos
Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2005;14(1):2-19.
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2005: Vestey Sarah B; Perks Claire M; Sen Chandan; Calder Caroline J; Holly Jeff M P; Winters Zoe E
Immunohistochemical expression of insulin-like growth factor binding protein-3 in invasive breast cancers and ductal carcinoma in situ: implications for clinicopathology and patient outcome.
Breast cancer research : BCR 2005;7(1):R119-29.
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2004: Macdonald Jamie H; Phanish Mysore K; Marcora Samuele M; Jibani Mahdi; Bloodworth Lionel L O; Holly Jeffrey M P; Lemmey Andrew B
Muscle insulin-like growth factor status, body composition, and functional capacity in hemodialysis patients.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2004;14(4):248-52.
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2004: Perks C M; Keith A J; Goodhew K L; Savage P B; Winters Z E; Holly J M P
Prolactin acts as a potent survival factor for human breast cancer cell lines.
British journal of cancer 2004;91(2):305-11.
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2004: Zhang Zun-Wu; Newcomb Paul V; Moorghen Moganaden; Gupta Jyoti; Feakins Roger; Savage Paul; Hollowood Andrew; Alderson Derek; Holly Jeff M P
Insulin-like growth factor binding protein-3: relationship to the development of gastric pre-malignancy and gastric adenocarcinoma (United Kingdom).
Cancer causes & control : CCC 2004;15(2):211-8.
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2004: Foulstone Emily J; Huser Camille; Crown Anna L; Holly Jeff M P; Stewart Claire E H
Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNFalpha.
Experimental cell research 2004;294(1):223-35.
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2004: Stewart C E H; Newcomb P V; Holly J M P
Multifaceted roles of TNF-alpha in myoblast destruction: a multitude of signal transduction pathways.
Journal of cellular physiology 2004;198(2):237-47.
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2004: Oliver Steven E; Barrass Barney; Gunnell David J; Donovan Jenny L; Peters Tim J; Persad Raj A; Gillatt David; Neal David E; Hamdy Freddie C; Holly Jeff M P
Serum insulin-like growth factor-I is positively associated with serum prostate-specific antigen in middle-aged men without evidence of prostate cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(1):163-5.
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2004: Gunnell D; Oliver S E; Donovan J L; Peters T J; Gillatt D; Persad R; Hamdy F C; Neal D E; Holly J M P
Do height-related variations in insulin-like growth factors underlie the associations of stature with adult chronic disease?
The Journal of clinical endocrinology and metabolism 2004;89(1):213-8.
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2003: Perks C M; Newcomb P V; Grohmann M; Wright R J; Mason H D; Holly J M P
Prolactin acts as a potent survival factor against C2-ceramide-induced apoptosis in human granulosa cells.
Human reproduction (Oxford, England) 2003;18(12):2672-7.
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2003: Foulstone E J; Savage P B; Crown A L; Holly J M; Stewart C E
Adaptations of the IGF system during malignancy: human skeletal muscle versus the systemic environment.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(11-12):667-74.
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2003: Louafi F; Stewart C E H; Perks C M; Thomas M G; Holly J M P
Role of the IGF-II receptor in mediating acute, non-genomic effects of retinoids and IGF-II on keratinocyte cell death.
Experimental dermatology 2003;12(4):426-34.
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2003: Fernihough Janet K; Innes John F; Billingham Michael E J; Holly Jeff M P
Changes in the local regulation of insulin-like growth factors I and II and insulin-like growth factor-binding proteins in osteoarthritis of the canine stifle joint secondary to cruciate ligament rupture.
Veterinary surgery : VS : the official journal of the American College of Veterinary Surgeons 2003;32(4):313-23.
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2003: Gunnell D; Oliver S E; Peters T J; Donovan J L; Persad R; Maynard M; Gillatt D; Pearce A; Hamdy F C; Neal D E; Holly J M P
Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged men.
British journal of cancer 2003;88(11):1682-6.
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2003: Foulstone Emily J; Savage Paul B; Crown Anna L; Holly Jeff M P; Stewart Claire E H
Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts.
Journal of cellular physiology 2003;195(1):70-9.
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2003: Collard T J; Guy M; Butt A J; Perks C M; Holly J M P; Paraskeva C; Williams A C
Transcriptional upregulation of the insulin-like growth factor binding protein IGFBP-3 by sodium butyrate increases IGF-independent apoptosis in human colonic adenoma-derived epithelial cells.
Carcinogenesis 2003;24(3):393-401.
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2003: Perks Claire M; Holly Jeff M P
The insulin-like growth factor (IGF) family and breast cancer.
Breast disease 2003;18():45-60.
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2003: Perks Claire M; Holly Jeff M P
IGFBPs and breast cancer.
Breast disease 2003;17():91-104.
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2002: McCaig Catherine; Perks Claire M; Holly Jeff M P
Intrinsic actions of IGFBP-3 and IGFBP-5 on Hs578T breast cancer epithelial cells: inhibition or accentuation of attachment and survival is dependent upon the presence of fibronectin.
Journal of cell science 2002;115(Pt 22):4293-303.
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2002: Wright Rebecca J; Holly Jeffrey M P; Galea Ray; Brincat Mark; Mason Helen D
Insulin-like growth factor (IGF)-independent effects of IGF binding protein-4 on human granulosa cell steroidogenesis.
Biology of reproduction 2002;67(3):776-81.
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2002: McCaig C; Fowler C A; Laurence N J; Lai T; Savage P B; Holly J M P; Perks C M
Differential interactions between IGFBP-3 and transforming growth factor-beta (TGF-beta) in normal vs cancerous breast epithelial cells.
British journal of cancer 2002;86(12):1963-9.
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2002: Perks C M; McCaig C; Clarke J B; Clemmons D R; Holly J M P
Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells.
Biochemical and biophysical research communications 2002;294(5):995-1000.
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2002: Perks C M; McCaig C; Clarke J B; Clemmons D R; Holly J M P
A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells.
Biochemical and biophysical research communications 2002;294(5):988-94.
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2002: Crown A L; Cottle K; Lightman S L; Falk S; Mohamed-Ali V; Armstrong L; Millar A B; Holly J M P
What is the role of the insulin-like growth factor system in the pathophysiology of cancer cachexia, and how is it regulated?
Clinical endocrinology 2002;56(6):723-33.
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2002: Helle Svein I; Ekse Dagfinn; Holly Jeff M P; Lønning Per E
The IGF-system in healthy pre- and postmenopausal women: relations to demographic variables and sex-steroids.
The Journal of steroid biochemistry and molecular biology 2002;81(1):95-102.
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2002: Hollowood A D; Stewart C E H; Perks C M; Pell J M; Lai T; Alderson D; Holly J M P
Evidence implicating a mid-region sequence of IGFBP-3 in its specific IGF-independent actions.
Journal of cellular biochemistry 2002;86(3):583-9.
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2002: McCaig Catherine; Perks Claire M; Holly Jeff M P
Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival.
Journal of cellular biochemistry 2002;84(4):784-94.
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2001: Foulstone E J; Meadows K A; Holly J M; Stewart C E
Insulin-like growth factors (IGF-I and IGF-II) inhibit C2 skeletal myoblast differentiation and enhance TNF alpha-induced apoptosis.
Journal of cellular physiology 2001;189(2):207-15.
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2001: Crowne E C; Samra J S; Cheetham T; Acerini C L; Watts A; Holly J M; Dunger D B
The role of IGF-binding proteins in mediating the effects of recombinant human IGF-I on insulin requirements in type 1 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2001;86(8):3686-91.
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2001: Helle S I; Geisler J; Anker G B; Leirvaag B; Holly J M; Lønning P E
Alterations in the insulin-like growth factor system during treatment with diethylstilboestrol in patients with metastatic breast cancer.
British journal of cancer 2001;85(2):147-51.
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2001: Helle S I; Geisler S; Aas T; Paulsen T; Holly J M; Lønning P E
Plasma insulin-like growth factor binding protein-3 proteolysis is increased in primary breast cancer.
British journal of cancer 2001;85(1):74-7.
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2001: Helle S I; Ueland T; Ekse D; Frøland S S; Holly J M; Lønning P E; Aukrust P
The insulin-like growth factor system in human immunodeficiency virus infection: relations to immunological parameters, disease progression, and antiretroviral therapy.
The Journal of clinical endocrinology and metabolism 2001;86(1):227-33.
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2001: Gunnell D; Okasha M; Smith G D; Oliver S E; Sandhu J; Holly J M
Height, leg length, and cancer risk: a systematic review.
Epidemiologic reviews 2001;23(2):313-42.
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2000: Crown A L; He X L; Holly J M; Lightman S L; Stewart C E
Characterisation of the IGF system in a primary adult human skeletal muscle cell model, and comparison of the effects of insulin and IGF-I on protein metabolism.
The Journal of endocrinology 2000;167(3):403-15.
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2000: Fowler C A; Perks C M; Newcomb P V; Savage P B; Farndon J R; Holly J M
Insulin-like growth factor binding protein-3 (IGFBP-3) potentiates paclitaxel-induced apoptosis in human breast cancer cells.
International journal of cancer. Journal international du cancer 2000;88(3):448-53.
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2000: Hollowood A D; Lai T; Perks C M; Newcomb P V; Alderson D; Holly J M
IGFBP-3 prolongs the p53 response and enhances apoptosis following UV irradiation.
International journal of cancer. Journal international du cancer 2000;88(3):336-41.
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2000: Perks C M; McCaig C; Holly J M
Differential insulin-like growth factor (IGF)-independent interactions of IGF binding protein-3 and IGF binding protein-5 on apoptosis in human breast cancer cells. Involvement of the mitochondria.
Journal of cellular biochemistry 2000;80(2):248-58.
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2000: Whellams E J; Maile L A; Fernihough J K; Billingham M E; Holly J M
Alterations in insulin-like growth factor binding protein-3 proteolysis and complex formation in the arthritic joint.
The Journal of endocrinology 2000;165(3):545-56.
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2000: Meadows K A; Holly J M; Stewart C E
Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts.
Journal of cellular physiology 2000;183(3):330-7.
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2000: Holly J M
Still more questions than answers: report on the 5th International Symposium on Insulin-like Growth Factors, Brighton, UK, 31 October-4 November 1999.
Trends in endocrinology and metabolism: TEM 2000;11(4):151-3.
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2000: Holly J M; Perks C M; Stewart C E
Overview of insulin-like growth factor physiology.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10 Suppl A():S8-9.
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2000: Maile L A; Whellams E J; Holly J M
Endogenous IGFBP-3 is protected from inducible IGFBP-3 protease activity in normal adult serum.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2000;10(2):71-7.
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2000: Holmes R P; Holly J M; Soothill P W
Maternal insulin-like growth factor binding protein-1, body mass index, and fetal growth.
Archives of disease in childhood. Fetal and neonatal edition 2000;82(2):F113-7.
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2000: Perks C M; Holly J M
Insulin-like growth factor binding proteins (IGFBPs) in breast cancer.
Journal of mammary gland biology and neoplasia 2000;5(1):75-84.
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2000: Williams A C; Collard T J; Perks C M; Newcomb P; Moorghen M; Holly J M; Paraskeva C
Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells.
Cancer research 2000;60(1):22-7.
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1999: Perks C M; Bowen S; Gill Z P; Newcomb P V; Holly J M
Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells.
Journal of cellular biochemistry 1999;75(4):652-64.
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1999: Taylor A M; Thomson A; Bruce-Morgan C; Ahmed M L; Watts A; Harris D; Holly J M; Dunger D B
The relationship between insulin, IGF-I and weight gain in cystic fibrosis.
Clinical endocrinology 1999;51(5):659-65.
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1999: Fernihough J K; Richmond R S; Carlson C S; Cherpes T; Holly J M; Loeser R F
Estrogen replacement therapy modulation of the insulin-like growth factor system in monkey knee joints.
Arthritis and rheumatism 1999;42(10):2103-11.
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1999: Holly J M; Gunnell D J; Davey Smith G
Growth hormone, IGF-I and cancer. Less intervention to avoid cancer? More intervention to prevent cancer?
The Journal of endocrinology 1999;162(3):321-30.
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1999: Maile L A; Gill Z P; Perks C M; Holly J M
The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells.
Endocrinology 1999;140(9):4040-5.
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1999: Stewart C E; Mihai R; Holly J M
Increased tyrosine kinase activity but not calcium mobilization is required for ceramide-induced apoptosis.
Experimental cell research 1999;250(2):329-38.
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1999: Helle S I; Lundgren S; Geisler S; Ekse D; Holly J M; Lønning P E
Effects of treatment with megestrol acetate on the insulin-like growth factor system: time and dose dependency.
European journal of cancer (Oxford, England : 1990) 1999;35(7):1070-5.
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1999: Holmes R P; Holly J M; Soothill P W
Maternal serum insulin-like growth factor binding protein-2 and -3 and fetal growth.
Human reproduction (Oxford, England) 1999;14(7):1879-84.
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1999: Zhu N W; Perks C M; Burd A R; Holly J M
Changes in the levels of integrin and focal adhesion kinase (FAK) in human melanoma cells following 532 nm laser treatment.
International journal of cancer. Journal international du cancer 1999;82(3):353-8.
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1999: Holmes R; Porter H; Newcomb P; Holly J M; Soothill P
An immunohistochemical study of type I insulin-like growth factor receptors in the placentae of pregnancies with appropriately grown or growth restricted fetuses.
Placenta 1999;20(4):325-30.
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1999: Stewart C E; Newcomb P V; Savage P B; Dickens M; Tavare J; Holly J M
Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1999;9(2):131-42.
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1999: Maile L A; Holly J M
Insulin-like growth factor binding protein (IGFBP) proteolysis: occurrence, identification, role and regulation.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 1999;9(2):85-95.
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1999: Perks C M; Newcomb P V; Norman M R; Holly J M
Effect of insulin-like growth factor binding protein-1 on integrin signalling and the induction of apoptosis in human breast cancer cells.
Journal of molecular endocrinology 1999;22(2):141-50.
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1999: Perks C M; Gill Z P; Newcomb P V; Holly J M
Activation of integrin and ceramide signalling pathways can inhibit the mitogenic effect of insulin-like growth factor I (IGF-I) in human breast cancer cell lines.
British journal of cancer 1999;79(5-6):701-6.
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1998: Holmes R P; Holly J M; Soothill P W
A prospective study of maternal serum insulin-like growth factor-I in pregnancies with appropriately grown or growth restricted fetuses.
British journal of obstetrics and gynaecology 1998;105(12):1273-8.
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1998: Maile L A; Xu S; Cwyfan-Hughes S C; Fernihough J K; Pell J M; Holly J M
Active and inhibitory components of the insulin-like growth factor binding protein-3 protease system in adult serum, interstitial, and synovial fluid.
Endocrinology 1998;139(12):4772-81.
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1998: Ogilvy-Stuart A L; Hands S J; Adcock C J; Holly J M; Matthews D R; Mohamed-Ali V; Yudkin J S; Wilkinson A R; Dunger D B
Insulin, insulin-like growth factor I (IGF-I), IGF-binding protein-1, growth hormone, and feeding in the newborn.
The Journal of clinical endocrinology and metabolism 1998;83(10):3550-7.
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1998: Helle S I; Jonat W; Giurescu M; Ekse D; Holly J M; Lønning P E
Influence of treatment with onapristone on the IGF-system in breast cancer patients.
The Journal of steroid biochemistry and molecular biology 1998;66(3):159-63.
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1998: Helle S I; Geisler J; Poulsen J P; Hestdal K; Meadows K; Collins W; Tveit K M; Holly J M; Lønning P E
Microencapsulated octreotide pamoate in advanced gastrointestinal and pancreatic cancer: a phase I study.
British journal of cancer 1998;78(1):14-20.
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1998: Cheetham T D; Holly J M; Baxter R C; Meadows K; Jones J; Taylor A M; Dunger D B
The effects of recombinant human IGF-I administration on concentrations of acid labile subunit, IGF binding protein-3, IGF-I, IGF-II and proteolysis of IGF binding protein-3 in adolescents with insulin-dependent diabetes mellitus.
The Journal of endocrinology 1998;157(1):81-7.
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1998: Helle S I; Anker G B; Meadows K A; Holly J M; Lønning P E
Alterations in the insulin-like growth factor system during the menstrual cycle in normal women.
Maturitas 1998;28(3):259-65.
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1998: Crowne E C; Samra J S; Cheetham T; Watts A; Holly J M; Dunger D B
Recombinant human insulin-like growth factor-I abolishes changes in insulin requirements consequent upon growth hormone pulsatility in young adults with type I diabetes mellitus.
Metabolism: clinical and experimental 1998;47(1):31-8.
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1998: Mason H D; Cwyfan-Hughes S; Holly J M; Franks S
Potent inhibition of human ovarian steroidogenesis by insulin-like growth factor binding protein-4 (IGFBP-4).
The Journal of clinical endocrinology and metabolism 1998;83(1):284-7.
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1997: Hughes S C; Mason H D; Franks S; Holly J M
The insulin-like growth factors (IGFs) in follicular fluid are predominantly bound in the ternary complex.
The Journal of endocrinology 1997;155(3):R1-4.
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1997: Gill Z P; Perks C M; Newcomb P V; Holly J M
Insulin-like growth factor-binding protein (IGFBP-3) predisposes breast cancer cells to programmed cell death in a non-IGF-dependent manner.
The Journal of biological chemistry 1997;272(41):25602-7.
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1997: Lemmey A B; Glassford J; Flick-Smith H C; Holly J M; Pell J M
Differential regulation of tissue insulin-like growth factor-binding protein (IGFBP)-3, IGF-I and IGF type 1 receptor mRNA levels, and serum IGF-I and IGFBP concentrations by growth hormone and IGF-I.
The Journal of endocrinology 1997;154(2):319-28.
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1997: Cwyfan Hughes S; Mason H D; Franks S; Holly J M
Modulation of the insulin-like growth factor-binding proteins by follicle size in the human ovary.
The Journal of endocrinology 1997;154(1):35-43.
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1997: Adcock C J; Ogilvy-Stuart A L; Robinson I C; Lewin J E; Holly J M; Harris D A; Watts A P; Doyle K L; Matthews D R; Wilkinson A R; Dunger D B
The use of an automated microsampling system for the characterization of growth hormone pulsatility in newborn babies.
Pediatric research 1997;42(1):66-71.
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1997: Xu S; Savage P; Burton J L; Sansom J; Holly J M
Proteolysis of insulin-like growth factor-binding protein-3 by human skin keratinocytes in culture in comparison to that in skin interstitial fluid: the role and regulation of components of the plasmin system.
The Journal of clinical endocrinology and metabolism 1997;82(6):1863-8.
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1996: Helle S I; Omsjø I H; Hughes S C; Botta L; Hüls G; Holly J M; Lønning P E
Effects of oral and transdermal oestrogen replacement therapy on plasma levels of insulin-like growth factors and IGF binding proteins 1 and 3: a cross-over study.
Clinical endocrinology 1996;45(6):727-32.
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1996: Fernihough J K; Billingham M E; Cwyfan-Hughes S; Holly J M
Local disruption of the insulin-like growth factor system in the arthritic joint.
Arthritis and rheumatism 1996;39(9):1556-65.
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1996: Timmins A C; Cotterill A M; Hughes S C; Holly J M; Ross R J; Blum W; Hinds C J
Critical illness is associated with low circulating concentrations of insulin-like growth factors-I and -II, alterations in insulin-like growth factor binding proteins, and induction of an insulin-like growth factor binding protein 3 protease.
Critical care medicine 1996;24(9):1460-6.
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1996: Helle S I; Holly J M; Tally M; Hall K; Vander Stappen J; Lønning P E
Influence of treatment with tamoxifen and change in tumor burden on the IGF-system in breast cancer patients.
International journal of cancer. Journal international du cancer 1996;69(4):335-9.
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1996: Acerini C L; Clayton K L; Hintz R; Baker B; Watts A; Holly J M; Dunger D B
Serum insulin-like growth factor II levels in normal adolescents and those with insulin dependent diabetes mellitus.
Clinical endocrinology 1996;45(1):13-9.
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1996: Frost V J; Helle S I; Lønning P E; van der Stappen J W; Holly J M
Effects of treatment with megestrol acetate, aminoglutethimide, or formestane on insulin-like growth factor (IGF) I and II, IGF-binding proteins (IGFBPs), and IGFBP-3 protease status in patients with advanced breast cancer.
The Journal of clinical endocrinology and metabolism 1996;81(6):2216-21.
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1996: Donnelly M J; Holly J M
The role of IGFBP-3 in the regulation of IGFBP-4 proteolysis.
The Journal of endocrinology 1996;149(3):R1-7.
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1996: Cotterill A M; Mendel P; Holly J M; Timmins A G; Camacho-Hübner C; Hughes S C; Ross R M; Blum W F; Langford R M
The differential regulation of the circulating levels of the insulin-like growth factors and their binding proteins (IGFBP) 1, 2 and 3 after elective abdominal surgery.
Clinical endocrinology 1996;44(1):91-101.
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1996: Xu S; Cwyfan-Hughes S C; van der Stappen J W; Sansom J; Burton J L; Donnelly M; Holly J M
Altered insulin-like growth factor-II (IGF-II) level and IGF-binding protein-3 (IGFBP-3) protease activity in interstitial fluid taken from the skin lesion of psoriasis.
The Journal of investigative dermatology 1996;106(1):109-12.
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1996: Mason H D; Cwyfan-Hughes S C; Heinrich G; Franks S; Holly J M
Insulin-like growth factor (IGF) I and II, IGF-binding proteins, and IGF-binding protein proteases are produced by theca and stroma of normal and polycystic human ovaries.
The Journal of clinical endocrinology and metabolism 1996;81(1):276-84.
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1995: Hughes S C; Johnson M R; Heinrich G; Holly J M
Could abnormalities in insulin-like growth factors and their binding proteins during pregnancy result in gestational diabetes?
The Journal of endocrinology 1995;147(3):517-24.
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1995: Cotterill A M; Daly F; Holly J M; Hughes S C; Camacho-Hübner C; Abdulla A F; Gale E A; Savage M O
The 'dawn phenomenon' in adolescents with insulin dependent diabetes mellitus: possible contribution of insulin-like growth factor binding protein-1.
Clinical endocrinology 1995;43(5):567-74.
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1995: Cheetham T D; Holly J M; Clayton K; Cwyfan-Hughes S; Dunger D B
The effects of repeated daily recombinant human insulin-like growth factor I administration in adolescents with type 1 diabetes.
Diabetic medicine : a journal of the British Diabetic Association 1995;12(10):885-92.
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1995: Xu S; Cwyfan-Hughes S C; van der Stappen J W; Sansom J; Burton J L; Donnelly M; Holly J M
Insulin-like growth factors (IGFs) and IGF-binding proteins in human skin interstitial fluid.
The Journal of clinical endocrinology and metabolism 1995;80(10):2940-5.
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1995: Holly J M
The insulin-like growth factors in critical illness: pathophysiology and therapeutic potential.
The Proceedings of the Nutrition Society 1995;54(2):591-9.
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1995: Hughes S C; Xu S; Fernihough J; Hampton A; Mason H D; Franks S; van der Stappen J; Donnelly M J; Holly J M
Tissue IGFBP-3 proteolysis: contrasting pathophysiology to that in the circulation.
Progress in growth factor research 1995;6(2-4):293-9.
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1994: Trainer P J; Holly J; Medbak S; Rees L H; Besser G M
The effect of recombinant IGF-I on anterior pituitary function in healthy volunteers.
Clinical endocrinology 1994;41(6):801-7.
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1994: Clayton K L; Holly J M; Carlsson L M; Jones J; Cheetham T D; Taylor A M; Dunger D B
Loss of the normal relationships between growth hormone, growth hormone-binding protein and insulin-like growth factor-I in adolescents with insulin-dependent diabetes mellitus.
Clinical endocrinology 1994;41(4):517-24.
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1994: Cheetham T D; Taylor A; Holly J M; Clayton K; Cwyfan-Hughes S; Dunger D B
The effects of recombinant human insulin-like growth factor-I (IGF-I) administration on the levels of IGF-I, IGF-II and IGF-binding proteins in adolescents with insulin-dependent diabetes mellitus.
The Journal of endocrinology 1994;142(2):367-74.
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1994: Adcock C J; Perry L A; Lindsell D R; Taylor A M; Holly J M; Jones J; Dunger D B
Menstrual irregularities are more common in adolescents with type 1 diabetes: association with poor glycaemic control and weight gain.
Diabetic medicine : a journal of the British Diabetic Association 1994;11(5):465-70.
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1994: Mason H D; Willis D S; Holly J M; Franks S
Insulin preincubation enhances insulin-like growth factor-II (IGF-II) action on steroidogenesis in human granulosa cells.
The Journal of clinical endocrinology and metabolism 1994;78(5):1265-7.
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1994: Cheetham T D; Clayton K L; Taylor A M; Holly J; Matthews D R; Dunger D B
The effects of recombinant human insulin-like growth factor I on growth hormone secretion in adolescents with insulin dependent diabetes mellitus.
Clinical endocrinology 1994;40(4):515-22.
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1994: Holly J M; Martin J L
Insulin-like growth factor binding proteins: a review of methodological aspects of their purification, analysis and regulation.
Growth regulation 1994;4 Suppl 1():20-30.
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1994: Holly J M; Hughes S C
Measuring insulin-like growth factors: why, where and how?
The Journal of endocrinology 1994;140(2):165-9.
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1993: Claffey D C; Yateman M E; Lane P A; Ealey P A; Wass J A; Marshall N J; Holly J M
The development and characterization of an eluted stain assay (ESTA) for the insulin-like growth factors.
Growth regulation 1993;3(4):215-25.
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1993: Cotterill A M; Holly J M; Wass J A
The regulation of insulin-like growth factor binding protein (IGFBP)-1 during prolonged fasting.
Clinical endocrinology 1993;39(3):357-62.
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1993: Eden J A; Holly J M; Alaghband-Zadeh J; Carter G D; Jones J
Relationship between follicular fluid levels of insulin-like growth factor binding protein-1 and sex steroids from normal human ovarian follicles.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 1993;7(3):153-7.
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1993: Frost V J; Macaulay V M; Wass J A; Holly J M
Proteolytic modification of insulin-like growth factor-binding proteins: comparison of conditioned media from human cell lines, circulating proteases and characterized enzymes.
The Journal of endocrinology 1993;138(3):545-54.
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1993: Cheetham T D; Jones J; Taylor A M; Holly J; Matthews D R; Dunger D B
The effects of recombinant insulin-like growth factor I administration on growth hormone levels and insulin requirements in adolescents with type 1 (insulin-dependent) diabetes mellitus.
Diabetologia 1993;36(7):678-81.
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1993: Cotterill A M; Camacho-Hübner C; Holly J M; Savage M O
The effect of recombinant human insulin-like growth factor-I treatment on growth hormone secretion in two subjects with growth hormone insensitivity (Laron syndrome).
Clinical endocrinology 1993;39(1):119-22.
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1993: Cotterill A M; Holly J M; Amiel S; Wass J A
Suppression of endogenous insulin secretion regulates the rapid rise of insulin-like growth factor binding protein (IGFBP)-1 levels following acute hypoglycaemia.
Clinical endocrinology 1993;38(6):633-9.
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1993: Cwyfan Hughes S C; Wass J A; Holly J M
Two site-specific radioimmunoassays which demonstrate the presence of proteolytically modified insulin-like growth factor-binding protein-3 in the circulation.
The Journal of endocrinology 1993;137(2):321-8.
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1993: Jenkins P J; Ibanez-Santos X; Holly J; Cotterill A; Perry L; Wolman R; Harries M; Grossman A
IGFBP-1: a metabolic signal associated with exercise-induced amenorrhoea.
Neuroendocrinology 1993;57(4):600-4.
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1993: Yateman M E; Claffey D C; Cwyfan Hughes S C; Frost V J; Wass J A; Holly J M
Cytokines modulate the sensitivity of human fibroblasts to stimulation with insulin-like growth factor-I (IGF-I) by altering endogenous IGF-binding protein production.
The Journal of endocrinology 1993;137(1):151-9.
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1993: Dunger D B; Cheetham T D; Holly J M; Matthews D R
Does recombinant insulin-like growth factor I have a role in the treatment of insulin-dependent diabetes mellitus during adolescence?
Acta paediatrica (Oslo, Norway : 1992). Supplement 1993;388():49-52; discussion 53.
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1993: Trainer P J; Holly J; Medbak S; Besser G M
Effect of recombinant insulin-like growth factor I on anterior pituitary function in healthy volunteers.
Acta paediatrica (Oslo, Norway : 1992). Supplement 1993;388():38; discussion 39.
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1993: Holly J M; Claffey D C; Cwyfan-Hughes S C; Frost V J; Yateman M E
Proteases acting on IGFBPs: their occurrence and physiological significance.
Growth regulation 1993;3(1):88-91.
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1992: Mason H D; Willis D; Holly J M; Cwyfan-Hughes S C; Seppala M; Franks S
Inhibitory effects of insulin-like growth factor-binding proteins on steroidogenesis by human granulosa cells in culture.
Molecular and cellular endocrinology 1992;89(1-2):R1-4.
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1992: Cwyfan Hughes S C; Cotterill A M; Molloy A R; Cassell T B; Braude N; Hinds C J; Wass J A; Holly J M
The induction of specific proteases for insulin-like growth factor-binding proteins following major heart surgery.
The Journal of endocrinology 1992;135(1):135-45.
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1992: Holly J M; Dunger D B; al-Othman S A; Savage M O; Wass J A
Sex hormone binding globulin levels in adolescent subjects with diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 1992;9(4):371-4.
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1992: Cotterill A M; Holly J M; Taylor A M; Davies S C; Coulson V J; Preece M A; Wass J A; Savage M O
The insulin-like growth factor (IGF)-binding proteins and IGF bioactivity in Laron-type dwarfism.
The Journal of clinical endocrinology and metabolism 1992;74(1):56-63.
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1992: Savage M O; Smith C P; Dunger D B; Gale E A; Holly J M; Preece M A
Insulin and growth factors adaptation to normal puberty.
Hormone research 1992;37 Suppl 3():70-3.
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1991: Cotterill A M; Holly J M; Davies S C; Coulson V J; Price P A; Wass J A
The insulin-like growth factors and their binding proteins in a case of non-islet-cell tumour-associated hypoglycaemia.
The Journal of endocrinology 1991;131(2):303-11.
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1991: Coulson V J; Wass J A; Abdulla A F; Cotterill A M; Holly J M
Insulin-like growth factor binding proteins (IGFBPs) in acromegaly.
Growth regulation 1991;1(3):119-24.
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1991: Davies S C; Wass J A; Ross R J; Cotterill A M; Buchanan C R; Coulson V J; Holly J M
The induction of a specific protease for insulin-like growth factor binding protein-3 in the circulation during severe illness.
The Journal of endocrinology 1991;130(3):469-73.
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1991: Davies S C; Holly J M; Coulson V J; Cotterill A M; Abdulla A F; Whittaker P G; Chard T; Wass J A
The presence of cation-dependent proteases for insulin-like growth factor binding proteins does not alter the size distribution of insulin-like growth factors in pregnancy.
Clinical endocrinology 1991;34(6):501-6.
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1991: Holly J M; Cotterill A M; Jemmott R C; Shears D; al-Othman S; Chard T; Wass J A
Inter-relations between growth hormone, insulin, insulin-like growth factor-I (IGF-I), IGF-binding protein-1 (IGFBP-1) and sex hormone-binding globulin in acromegaly.
Clinical endocrinology 1991;34(4):275-80.
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1991: Dunger D B; Edge J A; Pal R; Taylor A M; Holly J M; Matthews D R
Impact of increased growth hormone secretion on carbohydrate metabolism in adolescents with diabetes.
Acta paediatrica Scandinavica. Supplement 1991;377():69-77; discussion 78.
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1991: Holly J M
The physiological role of IGFBP-1.
Acta endocrinologica 1991;124 Suppl 2():55-62.
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1991: Cotterill A M; Holly J M; Snodgrass G A; Savage M O
Regulation of growth hormone secretion in patients with growth hormone insensitivity.
Acta paediatrica Scandinavica. Supplement 1991;377():92-5.
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1990: Holly J M; Dunger D B; Edge J A; Smith C P; Chard T; Wass J A
Insulin-like growth factor binding protein-1 levels in diabetic adolescents and their relationship to metabolic control.
Diabetic medicine : a journal of the British Diabetic Association 1990;7(7):618-23.
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1990: Holly J M; Eden J A; Alaghband-Zadeh J; Carter G D; Jemmott R C; Cianfarani S; Chard T; Wass J A
Insulin-like growth factor binding proteins in follicular fluid from normal dominant and cohort follicles, polycystic and multicystic ovaries.
Clinical endocrinology 1990;33(1):53-64.
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1989: Holly J M; Smith C P; Dunger D B; Howell R J; Chard T; Perry L A; Savage M O; Cianfarani S; Rees L H; Wass J A
Relationship between the pubertal fall in sex hormone binding globulin and insulin-like growth factor binding protein-I. A synchronized approach to pubertal development?
Clinical endocrinology 1989;31(3):277-84.
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1989: Holly J M; Wass J A
Insulin-like growth factors; autocrine, paracrine or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments.
The Journal of endocrinology 1989;122(3):611-8.
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1989: Holly J M; Smith C P; Dunger D B; Edge J A; Biddlecombe R A; Williams A J; Howell R; Chard T; Savage M O; Rees L H
Levels of the small insulin-like growth factor-binding protein are strongly related to those of insulin in prepubertal and pubertal children but only weakly so after puberty.
The Journal of endocrinology 1989;121(2):383-7.
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1989: Olajide F; Howell R J; Wass J A; Holly J M; Bohn H; Grudzinskas J G; Chapman M G; Chard T
Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and gemeprost for termination of first trimester pregnancy.
Human reproduction (Oxford, England) 1989;4(3):337-40.
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1988: Holly J M; Biddlecombe R A; Dunger D B; Edge J A; Amiel S A; Howell R; Chard T; Rees L H; Wass J A
Circadian variation of GH-independent IGF-binding protein in diabetes mellitus and its relationship to insulin. A new role for insulin?
Clinical endocrinology 1988;29(6):667-75.
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1988: Holly J M; Amiel S A; Sandhu R R; Rees L H; Wass J A
The role of growth hormone in diabetes mellitus.
The Journal of endocrinology 1988;118(3):353-64.
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