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Geoffrey Holman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
21
Yang, Jing
9
Cushman, Samuel
8
Koumanov, Francoise
6
Zierath, Juleen
5
Hatanaka, Yasumaru
5
Pryor, PR
4
Hashimoto, Makoto
4
Lund, Sten
4
Clark, AE
4
Tatibouët, Arnaud
4
Wallberg-Henriksson, Harriet
3
Simpson, Ian
3
Chibalin, Alexander
2
Krook, Anna
2
Reaves, Barbara

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Publications

TOP 3
Fazakerley Daniel J; Lawrence Scott P; Lizunov Vladimir A; Cushman Samuel W; Holman Geoffrey D
A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling.
Holman Geoffrey D; Sakamoto Kei
Regulating the motor for GLUT4 vesicle traffic.
Miller Edward J; Li Ji; Sinusas Kevin M; Holman Geoffrey D; Young Lawrence H
Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart.

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All Publications

2009: Fazakerley Daniel J; Lawrence Scott P; Lizunov Vladimir A; Cushman Samuel W; Holman Geoffrey D
A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling.
Journal of cell science 2009;122(Pt 5):727-34.
2008: Holman Geoffrey D; Sakamoto Kei
Regulating the motor for GLUT4 vesicle traffic.
Cell metabolism 2008;8(5):344-6.
2007: Miller Edward J; Li Ji; Sinusas Kevin M; Holman Geoffrey D; Young Lawrence H
Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1922-8.
2007: Koumanov Françoise; Holman Geoffrey D
Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways.
The Biochemical journal 2007;403(2):e9-11.
2006: Yang Jing; Holman Geoffrey D
Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis.
Endocrinology 2006;147(6):2728-36.
2005: Koumanov Françoise; Jin Bo; Yang Jing; Holman Geoffrey D
Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step.
Cell metabolism 2005;2(3):179-89.
2005: Ribé David; Yang Jing; Patel Sunil; Koumanov Françoise; Cushman Samuel W; Holman Geoffrey D
Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580.
Endocrinology 2005;146(4):1713-7.
2005: Yang Jing; Holman Geoffrey D
Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes.
The Journal of biological chemistry 2005;280(6):4070-8.
2004: Li Ji; Hu Xiaoyue; Selvakumar Pradeepa; Russell Raymond R; Cushman Samuel W; Holman Geoffrey D; Young Lawrence H
Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle.
American journal of physiology. Endocrinology and metabolism 2004;287(5):E834-41.
2003: Whitley Paul; Reaves Barbara J; Hashimoto Makoto; Riley Andrew M; Potter Barry V L; Holman Geoffrey D
Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.
The Journal of biological chemistry 2003;278(40):38786-95.
2003: Al-Khalili L; Chibalin A V; Kannisto K; Zhang B B; Permert J; Holman G D; Ehrenborg E; Ding V D H; Zierath J R; Krook A
Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content.
Cellular and molecular life sciences : CMLS 2003;60(5):991-8.
2003: Koistinen Heikki A; Galuska Dana; Chibalin Alexander V; Yang Jing; Zierath Juleen R; Holman Geoffrey D; Wallberg-Henriksson Harriet
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.
Diabetes 2003;52(5):1066-72.
2003: Girniene Jolanta; Tatibouët Arnaud; Sackus Algirdas; Yang Jing; Holman Geoffrey D; Rollin Patrick
Inhibition of the D-fructose transporter protein GLUT5 by fused-ring glyco-1,3-oxazolidin-2-thiones and -oxazolidin-2-ones.
Carbohydrate research 2003;338(8):711-9.
2002: Yang Jing; Gillingham Alison K; Hodel Alois; Koumanov Francoise; Woodward Brian; Holman Geoffrey D
Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes.
American journal of physiology. Endocrinology and metabolism 2002;283(6):E1299-307.
2002: Yang Jing; Dowden James; Tatibouët Arnaud; Hatanaka Yasumaru; Holman Geoffrey D
Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5.
The Biochemical journal 2002;367(Pt 2):533-9.
2002: Hashimoto Makoto; Yang Jing; Hatanaka Yasumaru; Sadakane Yutaka; Nakagomi Kazuya; Holman Geoffrey David
Improvement in the properties of 3-phenyl-3-trifluoromethyldiazirine based photoreactive bis-glucose probes for GLUT4 following substitution on the phenyl ring.
Chemical & pharmaceutical bulletin 2002;50(7):1004-6.
2002: Whitley Paul; Gibbard Alison M; Koumanov Françoise; Oldfield Susan; Kilgour Elaine E; Prestwich Glenn D; Holman Geoffrey D
Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.
European journal of cell biology 2002;81(4):222-30.
2002: Yang Jing; Hodel Alois; Holman Geoffrey D
Insulin and isoproterenol have opposing roles in the maintenance of cytosol pH and optimal fusion of GLUT4 vesicles with the plasma membrane.
The Journal of biological chemistry 2002;277(8):6559-66.
2001: Tatibouët A; Lefoix M; Nadolny J; Martin O R; Rollin P; Yang J; Holman G D
D-Fructose-L-sorbose interconversions. Access to 5-thio-D-fructose and interaction with the D-fructose transporter, GLUT5.
Carbohydrate research 2001;333(4):327-34.
2001: Holman G D; Sandoval I V
Moving the insulin-regulated glucose transporter GLUT4 into and out of storage.
Trends in cell biology 2001;11(4):173-9.
2001: Hashimoto M; Hatanaka Y; Yang J; Dhesi J; Holman G D
Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling.
Carbohydrate research 2001;331(2):119-27.
2001: Hashimoto M; Yang J; Holman G D
Cell-surface recognition of biotinylated membrane proteins requires very long spacer arms: an example from glucose-transporter probes.
Chembiochem : a European journal of chemical biology 2001;2(1):52-9.
2000: Sandoval I V; Martinez-Arca S; Valdueza J; Palacios S; Holman G D
Distinct reading of different structural determinants modulates the dileucine-mediated transport steps of the lysosomal membrane protein LIMPII and the insulin-sensitive glucose transporter GLUT4.
The Journal of biological chemistry 2000;275(51):39874-85.
2000: Tatibouët A; Yang J; Morin C; Holman G D
Synthesis and evaluation of fructose analogues as inhibitors of the D-fructose transporter GLUT5.
Bioorganic & medicinal chemistry 2000;8(7):1825-33.
2000: Pryor P R; Liu S C; Clark A E; Yang J; Holman G D; Tosh D
Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin.
The Biochemical journal 2000;348 Pt 1():83-91.
2000: Ryder J W; Yang J; Galuska D; Rincón J; Björnholm M; Krook A; Lund S; Pedersen O; Wallberg-Henriksson H; Zierath J R; Holman G D
Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients.
Diabetes 2000;49(4):647-54.
1999: Gillingham A K; Koumanov F; Pryor P R; Reaves B J; Holman G D
Association of AP1 adaptor complexes with GLUT4 vesicles.
Journal of cell science 1999;112 ( Pt 24)():4793-800.
1999: Holman G D
A new deadly Syn?
Current biology : CB 1999;9(19):R735-7.
1999: Ryder J W; Kawano Y; Chibalin A V; Rincón J; Tsao T S; Stenbit A E; Combatsiaris T; Yang J; Holman G D; Charron M J; Zierath J R
In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle.
The Biochemical journal 1999;342 ( Pt 2)():321-8.
1998: Lund S; Pryor P R; Ostergaard S; Schmitz O; Pedersen O; Holman G D
Evidence against protein kinase B as a mediator of contraction-induced glucose transport and GLUT4 translocation in rat skeletal muscle.
FEBS letters 1998;425(3):472-4.
1998: Koumanov F; Yang J; Jones A E; Hatanaka Y; Holman G D
Cell-surface biotinylation of GLUT4 using bis-mannose photolabels.
The Biochemical journal 1998;330 ( Pt 3)():1209-15.
1997: Lund S; Holman G D; Zierath J R; Rincon J; Nolte L A; Clark A E; Schmitz O; Pedersen O; Wallberg-Henriksson H
Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique.
Diabetes 1997;46(12):1965-9.
1997: Holman G D; Kasuga M
From receptor to transporter: insulin signalling to glucose transport.
Diabetologia 1997;40(9):991-1003.
1997: Pryor P R; Young P W; Holman G D
In situ labelling of insulin stimulated GTP-binding proteins in adipocytes.
Biochemical Society transactions 1997;25(3):475S.
1997: Koumanov F; Yang J; Jones A; Hatanaka Y; Holman G D
Cell surface biotinylation of GLUT4.
Biochemical Society transactions 1997;25(3):470S.
1997: Tosh D; Clark A E; Pryor P R; Yang J; Holman G D
Alterted GLUT4 subcellular trafficking in primary cultures of rat adipocytes.
Biochemical Society transactions 1997;25(3):469S.
1997: Lund S; Pedersen O; Holman G D; Clark A E; Zierath J R; Wallberg-Henriksson H
GLUT4 translocation in human muscle strips.
Biochemical Society transactions 1997;25(3):466S.
1997: Cushman W; Satoh S; Timmers K I; Malide D; Holman G D
Cell biology of insulin action on glucose transport.
The Japanese journal of physiology 1997;47 Suppl 1():S39.
1996: Timmers K I; Clark A E; Omatsu-Kanbe M; Whiteheart S W; Bennett M K; Holman G D; Cushman S W
Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein.
The Biochemical journal 1996;320 ( Pt 2)():429-36.
1996: Cusdin F S; Robinson M J; Holman G D; Hough D W; Danson M J
Characterisation of glucose transport in the hyperthermophilic Archaeon Sulfolobus solfataricus.
FEBS letters 1996;387(2-3):193-5.
1996: Saravolac E G; Holman G D; Gould G W; Baldwin S A
The use of biotinylation in the detection and purification of affinity labelled Glut-1.
Biochemical Society transactions 1996;24(1):115S.
1996: Yang J; Clarke J F; Ester C J; Young P W; Kasuga M; Holman G D
Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells.
The Biochemical journal 1996;313 ( Pt 1)():125-31.
1995: Young P W; Cawthorne M A; Coyle P J; Holder J C; Holman G D; Kozka I J; Kirkham D M; Lister C A; Smith S A
Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling.
Diabetes 1995;44(9):1087-92.
1995: Kozka I J; Clark A E; Reckless J P; Cushman S W; Gould G W; Holman G D
The effects of insulin on the level and activity of the GLUT4 present in human adipose cells.
Diabetologia 1995;38(6):661-6.
1994: Holman G D; Cushman S W
Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin-responsive cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 1994;16(10):753-9.
1994: Lund S; Flyvbjerg A; Holman G D; Larsen F S; Pedersen O; Schmitz O
Comparative effects of IGF-I and insulin on the glucose transporter system in rat muscle.
The American journal of physiology 1994;267(3 Pt 1):E461-6.
1994: Holman G D; Lo Leggio L; Cushman S W
Insulin-stimulated GLUT4 glucose transporter recycling. A problem in membrane protein subcellular trafficking through multiple pools.
The Journal of biological chemistry 1994;269(26):17516-24.
1994: Clarke J F; Young P W; Yonezawa K; Kasuga M; Holman G D
Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin.
The Biochemical journal 1994;300 ( Pt 3)():631-5.
1994: Cope D L; Holman G D; Baldwin S A; Wolstenholme A J
Domain assembly of the GLUT1 glucose transporter.
The Biochemical journal 1994;300 ( Pt 2)():291-4.
1993: Satoh S; Nishimura H; Clark A E; Kozka I J; Vannucci S J; Simpson I A; Quon M J; Cushman S W; Holman G D
Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action.
The Journal of biological chemistry 1993;268(24):17820-9.
1993: Kozka I J; Holman G D
Metformin blocks downregulation of cell surface GLUT4 caused by chronic insulin treatment of rat adipocytes.
Diabetes 1993;42(8):1159-65.
1993: Fry A J; Towner P; Holman G D; Eisenthal R
Transport of D-fructose and its analogues by Trypanosoma brucei.
Molecular and biochemical parasitology 1993;60(1):9-18.
1993: Yang J; Holman G D
Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.
The Journal of biological chemistry 1993;268(7):4600-3.
1992: Vannucci S J; Nishimura H; Satoh S; Cushman S W; Holman G D; Simpson I A
Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine.
The Biochemical journal 1992;288 ( Pt 1)():325-30.
1992: Jordan N J; Holman G D
Photolabelling of the liver-type glucose-transporter isoform GLUT2 with an azitrifluoroethylbenzoyl-substituted bis-D-mannose.
The Biochemical journal 1992;286 ( Pt 2)():649-56.
1992: Palfreyman R W; Clark A E; Denton R M; Holman G D; Kozka I J
Kinetic resolution of the separate GLUT1 and GLUT4 glucose transport activities in 3T3-L1 cells.
The Biochemical journal 1992;284 ( Pt 1)():275-82.
1992: Yang J; Clark A E; Kozka I J; Cushman S W; Holman G D
Development of an intracellular pool of glucose transporters in 3T3-L1 cells.
The Journal of biological chemistry 1992;267(15):10393-9.
1992: Yang J; Clark A E; Harrison R; Kozka I J; Holman G D
Trafficking of glucose transporters in 3T3-L1 cells. Inhibition of trafficking by phenylarsine oxide implicates a slow dissociation of transporters from trafficking proteins.
The Biochemical journal 1992;281 ( Pt 3)():809-17.
1991: Clark A E; Holman G D; Kozka I J
Determination of the rates of appearance and loss of glucose transporters at the cell surface of rat adipose cells.
The Biochemical journal 1991;278 ( Pt 1)():235-41.
1991: Kozka I J; Clark A E; Holman G D
Chronic treatment with insulin selectively down-regulates cell-surface GLUT4 glucose transporters in 3T3-L1 adipocytes.
The Journal of biological chemistry 1991;266(18):11726-31.
1990: Holman G D; Kozka I J; Clark A E; Flower C J; Saltis J; Habberfield A D; Simpson I A; Cushman S W
Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.
The Journal of biological chemistry 1990;265(30):18172-9.
1990: Kozka I J; Clark A E; Bramble C L; Holman G D
Cell-surface labelling of glucose transporters in rat adipocytes.
Biochemical Society transactions 1990;18(5):945-6.
1990: Clark A E; Holman G D
Exofacial photolabelling of the human erythrocyte glucose transporter with an azitrifluoroethylbenzoyl-substituted bismannose.
The Biochemical journal 1990;269(3):615-22.
1989: Eisenthal R; Game S; Holman G D
Specificity and kinetics of hexose transport in Trypanosoma brucei.
Biochimica et biophysica acta 1989;985(1):81-9.
1989: Holman G D
Side-specific photolabelling of the hexose transporter.
Biochemical Society transactions 1989;17(3):438-40.
1988: Holman G D; Karim A R; Karim B
Photolabeling of erythrocyte and adipocyte hexose transporters using a benzophenone derivative of bis(D-mannose).
Biochimica et biophysica acta 1988;946(1):75-84.
1987: Karim A R; Rees W D; Holman G D
Binding of cytochalasin B to trypsin and thermolysin fragments of the human erythrocyte hexose transporter.
Biochimica et biophysica acta 1987;902(3):402-5.

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