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Geoffrey Holman

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Françoise Koumanov; Vinit J Pereira; Paul Whitley; Geoffrey D Holman
GLUT4 traffic through an ESCRT-III-dependent sorting compartment in adipocytes.
Françoise Koumanov; Judith D Richardson; Beverley A Murrow; Geoffrey D Holman
AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane.
Scott P Lawrence; Geoffrey D Holman; Francoise Koumanov
Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling.

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All Publications

2012: Françoise Koumanov; Vinit J Pereira; Paul Whitley; Geoffrey D Holman
GLUT4 traffic through an ESCRT-III-dependent sorting compartment in adipocytes.
PloS one 2012;7(9):e44141.
2011: Françoise Koumanov; Judith D Richardson; Beverley A Murrow; Geoffrey D Holman
AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane.
The Journal of biological chemistry 2011;286(19):16574-82.
2010: Scott P Lawrence; Geoffrey D Holman; Francoise Koumanov
Translocation of the Na+/H+ exchanger 1 (NHE1) in cardiomyocyte responses to insulin and energy-status signalling.
The Biochemical journal 2010;432(3):515-23.
2010: Daniel J Fazakerley; Geoffrey D Holman; Anna Marley; David E James; Jacqueline Stöckli; Adelle Coster
Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubes.
The Journal of biological chemistry 2010;285(3):1653-60.
2009: Daniel J Fazakerley; Scott P Lawrence; Vladimir A Lizunov; Samuel W Cushman; Geoffrey D Holman
A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling.
Journal of cell science 2009;122(Pt 5):727-34.
2008: Geoffrey D Holman; Kei Sakamoto
Regulating the motor for GLUT4 vesicle traffic.
Cell metabolism 2008;8(5):344-6.
2007: Edward J Miller; Li Ji; Kevin M Sinusas; Geoffrey D Holman; Lawrence H Young
Infusion of a biotinylated bis-glucose photolabel: a new method to quantify cell surface GLUT4 in the intact mouse heart.
American journal of physiology. Endocrinology and metabolism 2007;292(6):E1922-8.
2007: Francoise Koumanov; Geoffrey D Holman
Thrifty Tbc1d1 and Tbc1d4 proteins link signalling and membrane trafficking pathways.
The Biochemical journal 2007;403(2):e9-11.
2006: Jing Yang; Geoffrey D Holman
Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis.
Endocrinology 2006;147(6):2728-36.
2005: Francoise Koumanov; Bo Jin; Jing Yang; Geoffrey D Holman
Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step.
Cell metabolism 2005;2(3):179-89.
2005: David Ribé; Jing Yang; Sunil Patel; Francoise Koumanov; Samuel W Cushman; Geoffrey D Holman
Endofacial competitive inhibition of glucose transporter-4 intrinsic activity by the mitogen-activated protein kinase inhibitor SB203580.
Endocrinology 2005;146(4):1713-7.
2005: Jing Yang; Geoffrey D Holman
Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes.
The Journal of biological chemistry 2005;280(6):4070-8.
2004: Li Ji; Xiaoyue Hu; Pradeepa Selvakumar; Raymond R Russell; Samuel W Cushman; Geoffrey D Holman; Lawrence H Young
Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle.
American journal of physiology. Endocrinology and metabolism 2004;287(5):E834-41.
2003: Paul Whitley; Barbara J Reaves; Makoto Hashimoto; Andrew M Riley; Barry V L Potter; Geoffrey D Holman
Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.
The Journal of biological chemistry 2003;278(40):38786-95.
2003: Lubna Al-Khalili; Alexander V Chibalin; Katja Kannisto; B B Zhang; J Permert; Geoffrey D Holman; Ewa Ehrenborg; V D H Ding; Juleen R Zierath; Anna Krook
Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content.
Cellular and molecular life sciences : CMLS 2003;60(5):991-8.
2003: Heikki A Koistinen; Dana Galuska; Alexander V Chibalin; Jing Yang; Juleen R Zierath; Geoffrey D Holman; Harriet Wallberg-Henriksson
5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.
Diabetes 2003;52(5):1066-72.
2003: Jolanta Girniene; Arnaud Tatibouët; Algirdas Sackus; Jing Yang; Geoffrey D Holman; Patrick Rollin
Inhibition of the D-fructose transporter protein GLUT5 by fused-ring glyco-1,3-oxazolidin-2-thiones and -oxazolidin-2-ones.
Carbohydrate research 2003;338(8):711-9.
2002: Jing Yang; Alison K Gillingham; Alois Hodel; Francoise Koumanov; Brian Woodward; Geoffrey D Holman
Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes.
American journal of physiology. Endocrinology and metabolism 2002;283(6):E1299-307.
2002: Jing Yang; James Dowden; Arnaud Tatibouët; Yasumaru Hatanaka; Geoffrey D Holman
Development of high-affinity ligands and photoaffinity labels for the D-fructose transporter GLUT5.
The Biochemical journal 2002;367(Pt 2):533-9.
2002: Makoto Hashimoto; Jing Yang; Yasumaru Hatanaka; Yutaka Sadakane; Kazuya Nakagomi; Geoffrey D Holman
Improvement in the properties of 3-phenyl-3-trifluoromethyldiazirine based photoreactive bis-glucose probes for GLUT4 following substitution on the phenyl ring.
Chemical & pharmaceutical bulletin 2002;50(7):1004-6.
2002: Paul Whitley; Alison M Gibbard; Francoise Koumanov; Susan Oldfield; Elaine E Kilgour; Glenn D Prestwich; Geoffrey D Holman
Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle.
European journal of cell biology 2002;81(4):222-30.
2002: Jing Yang; Alois Hodel; Geoffrey D Holman
Insulin and isoproterenol have opposing roles in the maintenance of cytosol pH and optimal fusion of GLUT4 vesicles with the plasma membrane.
The Journal of biological chemistry 2002;277(8):6559-66.
2001: Arnaud Tatibouët; M Lefoix; J Nadolny; Olivier R Martin; Patrick Rollin; Jing Yang; Geoffrey D Holman
D-Fructose-L-sorbose interconversions. Access to 5-thio-D-fructose and interaction with the D-fructose transporter, GLUT5.
Carbohydrate research 2001;333(4):327-34.
2001: Geoffrey D Holman; Ignacio V Sandoval
Moving the insulin-regulated glucose transporter GLUT4 into and out of storage.
Trends in cell biology 2001;11(4):173-9.
2001: Makoto Hashimoto; Yasumaru Hatanaka; Jing Yang; J Dhesi; Geoffrey D Holman
Synthesis of biotinylated bis(D-glucose) derivatives for glucose transporter photoaffinity labelling.
Carbohydrate research 2001;331(2):119-27.
2001: Makoto Hashimoto; Jing Yang; Geoffrey D Holman
Cell-surface recognition of biotinylated membrane proteins requires very long spacer arms: an example from glucose-transporter probes.
Chembiochem : a European journal of chemical biology 2001;2(1):52-9.
2000: Ignacio V Sandoval; S Martinez-Arca; J Valdueza; S Palacios; Geoffrey D Holman
Distinct reading of different structural determinants modulates the dileucine-mediated transport steps of the lysosomal membrane protein LIMPII and the insulin-sensitive glucose transporter GLUT4.
The Journal of biological chemistry 2000;275(51):39874-85.
2000: Arnaud Tatibouët; Jing Yang; C Morin; Geoffrey D Holman
Synthesis and evaluation of fructose analogues as inhibitors of the D-fructose transporter GLUT5.
Bioorganic & medicinal chemistry 2000;8(7):1825-33.
2000: PR Pryor; S C Liu; AE Clark; Jing Yang; Geoffrey D Holman; David Tosh
Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin.
The Biochemical journal 2000;348 Pt 1():83-91.
2000: Jeffrey W Ryder; J Yang; Dana Galuska; J Rincón; Marie Björnholm; Anna Krook; Sten Lund; O Pedersen; Harriet Wallberg-Henriksson; Juleen R Zierath; Geoffrey D Holman
Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients.
Diabetes 2000;49(4):647-54.
1999: A K Gillingham; Francoise Koumanov; PR Pryor; Barbara J Reaves; Geoffrey D Holman
Association of AP1 adaptor complexes with GLUT4 vesicles.
Journal of cell science 1999;112 ( Pt 24)():4793-800.
1999: Geoffrey D Holman
A new deadly Syn?
Current biology : CB 1999;9(19):R735-7.
1999: Jeffrey W Ryder; Y Kawano; Alexander V Chibalin; J Rincón; Tsu-Shuen Tsao; Antine Elaine Stenbit; TP Combatsiaris; J Yang; Geoffrey D Holman; Maureen J Charron; Juleen R Zierath
In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle.
The Biochemical journal 1999;342 ( Pt 2)():321-8.
1998: Sten Lund; PR Pryor; S Ostergaard; Ole Schmitz; O Pedersen; Geoffrey D Holman
Evidence against protein kinase B as a mediator of contraction-induced glucose transport and GLUT4 translocation in rat skeletal muscle.
FEBS letters 1998;425(3):472-4.
1998: Francoise Koumanov; Jing Yang; A E Jones; Yasumaru Hatanaka; Geoffrey D Holman
Cell-surface biotinylation of GLUT4 using bis-mannose photolabels.
The Biochemical journal 1998;330 ( Pt 3)():1209-15.
1997: Sten Lund; Geoffrey D Holman; Juleen R Zierath; J Rincon; LA Nolte; AE Clark; Ole Schmitz; O Pedersen; Harriet Wallberg-Henriksson
Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique.
Diabetes 1997;46(12):1965-9.
1997: Geoffrey D Holman; M Kasuga
From receptor to transporter: insulin signalling to glucose transport.
Diabetologia 1997;40(9):991-1003.
1997: PR Pryor; P W Young; Geoffrey D Holman
In situ labelling of insulin stimulated GTP-binding proteins in adipocytes.
Biochemical Society transactions 1997;25(3):475S.
1997: Francoise Koumanov; Jing Yang; A Jones; Yasumaru Hatanaka; Geoffrey D Holman
Cell surface biotinylation of GLUT4.
Biochemical Society transactions 1997;25(3):470S.
1997: David Tosh; AE Clark; PR Pryor; Jing Yang; Geoffrey D Holman
Alterted GLUT4 subcellular trafficking in primary cultures of rat adipocytes.
Biochemical Society transactions 1997;25(3):469S.
1997: Sten Lund; O Pedersen; Geoffrey D Holman; AE Clark; Juleen R Zierath; Harriet Wallberg-Henriksson
GLUT4 translocation in human muscle strips.
Biochemical Society transactions 1997;25(3):466S.
1997: W Cushman; S Satoh; K I Timmers; Daniela Malide; Geoffrey D Holman
Cell biology of insulin action on glucose transport.
The Japanese journal of physiology 1997;47 Suppl 1():S39.
1996: K I Timmers; A E Clark; M Omatsu-Kanbe; S W Whiteheart; M K Bennett; Geoffrey D Holman; Samuel W Cushman
Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein.
The Biochemical journal 1996;320 ( Pt 2)():429-36.
1996: F S Cusdin; M J Robinson; Geoffrey D Holman; David W Hough; Michael J Danson
Characterisation of glucose transport in the hyperthermophilic Archaeon Sulfolobus solfataricus.
FEBS letters 1996;387(2-3):193-5.
1996: Edward Saravolac; Geoffrey D Holman; G W Gould; S A Baldwin
The use of biotinylation in the detection and purification of affinity labelled Glut-1.
Biochemical Society transactions 1996;24(1):115S.
1996: Jing Yang; J F Clarke; C J Ester; P W Young; M Kasuga; Geoffrey D Holman
Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells.
The Biochemical journal 1996;313 ( Pt 1)():125-31.
1995: P W Young; Michael A Cawthorne; P J Coyle; Julie C Holder; Geoffrey D Holman; I J Kozka; D M Kirkham; C A Lister; Stephen A Smith
Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling.
Diabetes 1995;44(9):1087-92.
1995: I J Kozka; A E Clark; J P Reckless; Samuel W Cushman; G W Gould; Geoffrey D Holman
The effects of insulin on the level and activity of the GLUT4 present in human adipose cells.
Diabetologia 1995;38(6):661-6.
1994: Geoffrey D Holman; Samuel W Cushman
Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin-responsive cells.
BioEssays : news and reviews in molecular, cellular and developmental biology 1994;16(10):753-9.
1994: S Lund; A Flyvbjerg; Geoffrey D Holman; F S Larsen; O Pedersen; O Schmitz
Comparative effects of IGF-I and insulin on the glucose transporter system in rat muscle.
The American journal of physiology 1994;267(3 Pt 1):E461-6.
1994: Geoffrey D Holman; L Lo Leggio; Samuel W Cushman
Insulin-stimulated GLUT4 glucose transporter recycling. A problem in membrane protein subcellular trafficking through multiple pools.
The Journal of biological chemistry 1994;269(26):17516-24.
1994: J F Clarke; P W Young; K Yonezawa; M Kasuga; Geoffrey D Holman
Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin.
The Biochemical journal 1994;300 ( Pt 3)():631-5.
1994: D L Cope; Geoffrey D Holman; S A Baldwin; Adrian J Wolstenholme
Domain assembly of the GLUT1 glucose transporter.
The Biochemical journal 1994;300 ( Pt 2)():291-4.
1993: S Satoh; H Nishimura; A E Clark; I J Kozka; Susan J Vannucci; Ian A Simpson; Michael Quon; Samuel W Cushman; Geoffrey D Holman
Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action.
The Journal of biological chemistry 1993;268(24):17820-9.
1993: I J Kozka; Geoffrey D Holman
Metformin blocks downregulation of cell surface GLUT4 caused by chronic insulin treatment of rat adipocytes.
Diabetes 1993;42(8):1159-65.
1993: A J Fry; P Towner; Geoffrey D Holman; Robert Eisenthal
Transport of D-fructose and its analogues by Trypanosoma brucei.
Molecular and biochemical parasitology 1993;60(1):9-18.
1993: Jing Yang; Geoffrey D Holman
Comparison of GLUT4 and GLUT1 subcellular trafficking in basal and insulin-stimulated 3T3-L1 cells.
The Journal of biological chemistry 1993;268(7):4600-3.
1992: Susan J Vannucci; H Nishimura; S Satoh; Samuel W Cushman; Geoffrey D Holman; Ian A Simpson
Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine.
The Biochemical journal 1992;288 ( Pt 1)():325-30.
1992: N J Jordan; Geoffrey D Holman
Photolabelling of the liver-type glucose-transporter isoform GLUT2 with an azitrifluoroethylbenzoyl-substituted bis-D-mannose.
The Biochemical journal 1992;286 ( Pt 2)():649-56.
1992: Jing Yang; A E Clark; I J Kozka; Samuel W Cushman; Geoffrey D Holman
Development of an intracellular pool of glucose transporters in 3T3-L1 cells.
The Journal of biological chemistry 1992;267(15):10393-9.
1992: R W Palfreyman; A E Clark; R M Denton; Geoffrey D Holman; I J Kozka
Kinetic resolution of the separate GLUT1 and GLUT4 glucose transport activities in 3T3-L1 cells.
The Biochemical journal 1992;284 ( Pt 1)():275-82.
1992: Jing Yang; A E Clark; R Harrison; I J Kozka; Geoffrey D Holman
Trafficking of glucose transporters in 3T3-L1 cells. Inhibition of trafficking by phenylarsine oxide implicates a slow dissociation of transporters from trafficking proteins.
The Biochemical journal 1992;281 ( Pt 3)():809-17.
1991: A E Clark; Geoffrey D Holman; I J Kozka
Determination of the rates of appearance and loss of glucose transporters at the cell surface of rat adipose cells.
The Biochemical journal 1991;278 ( Pt 1)():235-41.
1991: I J Kozka; A E Clark; Geoffrey D Holman
Chronic treatment with insulin selectively down-regulates cell-surface GLUT4 glucose transporters in 3T3-L1 adipocytes.
The Journal of biological chemistry 1991;266(18):11726-31.
1990: Geoffrey D Holman; I J Kozka; A E Clark; C J Flower; J Saltis; A D Habberfield; Ian A Simpson; Samuel W Cushman
Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester.
The Journal of biological chemistry 1990;265(30):18172-9.
1990: I J Kozka; A E Clark; C L Bramble; Geoffrey D Holman
Cell-surface labelling of glucose transporters in rat adipocytes.
Biochemical Society transactions 1990;18(5):945-6.
1990: A E Clark; Geoffrey D Holman
Exofacial photolabelling of the human erythrocyte glucose transporter with an azitrifluoroethylbenzoyl-substituted bismannose.
The Biochemical journal 1990;269(3):615-22.
1989: Robert Eisenthal; S Game; Geoffrey D Holman
Specificity and kinetics of hexose transport in Trypanosoma brucei.
Biochimica et biophysica acta 1989;985(1):81-9.
1989: Geoffrey D Holman
Side-specific photolabelling of the hexose transporter.
Biochemical Society transactions 1989;17(3):438-40.
1988: Geoffrey D Holman; A R Karim; B Karim
Photolabeling of erythrocyte and adipocyte hexose transporters using a benzophenone derivative of bis(D-mannose).
Biochimica et biophysica acta 1988;946(1):75-84.
1987: A R Karim; W D Rees; Geoffrey D Holman
Binding of cytochalasin B to trypsin and thermolysin fragments of the human erythrocyte hexose transporter.
Biochimica et biophysica acta 1987;902(3):402-5.