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Rikard Holmdahl

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Karin Lundberg; Leonid Padyukov; Iskra Pollak-Dorocic; Evan Reed; Lars Alfredsson; Camilla Bengtsson; Rikard Holmdahl; Lena Israelsson; Xia Jiang; Henrik Kallberg; Christoph Kessel; Nastya Kharlamova; Lars Klareskog
Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile.
Marilena Colaianna; Vincenzo Cuomo; Rikard Holmdahl; Karl-Heinz Krause; Maria Grazia Morgese; Stefania Schiavone; Paolo Tucci; Margherita Zotti; Liselotte Bäckdahl; Luigia Trabace
Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress.
Rikard Holmdahl; Noora Jaakkola; Tiina Kelkka; Lina M Olsson; Angela Pizzolla; Outi Sareila; Kajsa Wing; Susann Winter; Cecilia Hagert; Liselotte Bäckdahl
Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells.

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2013: Karin Lundberg; Leonid Padyukov; Iskra Pollak-Dorocic; Evan Reed; Lars Alfredsson; Camilla Bengtsson; Rikard Holmdahl; Lena Israelsson; Xia Jiang; Henrik Kallberg; Christoph Kessel; Nastya Kharlamova; Lars Klareskog
Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile.
Annals of the rheumatic diseases 2013;72(5):652-8.
2013: Marilena Colaianna; Vincenzo Cuomo; Rikard Holmdahl; Karl-Heinz Krause; Maria Grazia Morgese; Stefania Schiavone; Paolo Tucci; Margherita Zotti; Liselotte Bäckdahl; Luigia Trabace
Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress.
Antioxidants & redox signaling 2013;18(12):1385-99.
2013: Rikard Holmdahl; Noora Jaakkola; Tiina Kelkka; Lina M Olsson; Angela Pizzolla; Outi Sareila; Kajsa Wing; Susann Winter; Cecilia Hagert; Liselotte Bäckdahl
Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells.
Antioxidants & redox signaling 2013;18(12):1463-74.
2013: Melissa J Grimm; Tobias M Hohl; Rikard Holmdahl; Tiina Kelkka; A Nazmul H Khan; Paul R Knight; Michael K Mansour; Marc Röhm; Nikolaos G Almyroudis; Timothy S Blackwell; Anthony C D'Auria; Bruce A Davidson; Carly G Dennis; Kelly L Singel; Constantin F Urban; R Robert Vethanayagam; Jatin M Vyas; Brahm H Segal
Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):4175-84.
2013: Mikael Brink; Göran Hallmans; Monika Hansson; Rikard Holmdahl; Per-Johan Jakobsson; Lars Klareskog; Linda Mathsson; Johan Rönnelid; Hans Stenlund; Solbritt Rantapää-Dahlqvist
Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis.
Arthritis and rheumatism 2013;65(4):899-910.
2013: Outi Sareila; Noora Jaakkola; Tiina Kelkka; Peter Olofsson; Rikard Holmdahl
Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation.
Journal of leukocyte biology 2013;93(3):427-35.
2013: Allyson M Croxford; Rikard Holmdahl; Donald McNaughton; Kutty Selva Nandakumar; Senga Whittingham; Merrill J Rowley
Type II collagen-specific antibodies induce cartilage damage in mice independent of inflammation.
Arthritis and rheumatism 2013;65(3):650-9.
2012: Duygu B Bas; Simone Codeluppi; Rikard Holmdahl; Johanna Lundberg; Kutty Selva Nandakumar; Katalin Sandor; Jie Su; Nilesh M Agalave; Azar Baharpoor; Camilla I Svensson
Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency.
Arthritis and rheumatism 2012;64(12):3886-96.
2012: Sonja Herman; Martin Herrmann; Rikard Holmdahl; Angelika Kny; Birgit Niederreiter; Jürgen Pfatschbacher; Christine Schorn; Günter Steiner; Markus H Hoffmann
Cell death and cytokine production induced by autoimmunogenic hydrocarbon oils.
Autoimmunity 2012;45(8):602-11.
2012: Michael Förster; Emma Ahlqvist; Diana Ekman; Malin Hultqvist; Martina Johannesson; Dorota Klaczkowska; Therese Lindvall; Kutty Selva Nandakumar; Marjan Popovic; Bruno Raposo; Ivanka Teneva; Rikard Holmdahl
Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice.
Arthritis and rheumatism 2012;64(11):3594-603.
2012: Konstantin Yakimchuk; Liying Chen; Rikard Holmdahl; Kutty Selva Nandakumar; Sam Okret; Mikael Jondal
Keratinocyte growth factor (KGF) delays the onset of collagen-induced arthritis.
Autoimmunity 2012;45(7):510-5.
2012: Christine Deffert; Rikard Holmdahl; Tiina Kelkka; Karl-Heinz Krause; Anne-Laure Rougemont; Stephanie Carnesecchi; Huiping Yuan; Michela G Schäppi
Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells.
The Journal of pathology 2012;228(3):341-50.
2012: Lina M Olsson; Rikard Holmdahl
Copy number variation in autoimmunity--importance hidden in complexity?
European journal of immunology 2012;42(8):1969-76.
2012: Omri Snir; Ida Andersson; Johan Bäcklund; Julia Boström; Jane H Buckner; Rikard Holmdahl; Jan Kihlberg; Lars Klareskog; Vivianne Malmström
Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis.
Arthritis and rheumatism 2012;64(8):2482-8.
2012: Jonatan Tuncel; Anthony C Y Yau; Shemin Lu; Harald Burkhardt; Stefan Carlsén; Sabrina Haag; Rikard Holmdahl
Class II major histocompatibility complex-associated response to type XI collagen regulates the development of chronic arthritis in rats.
Arthritis and rheumatism 2012;64(8):2537-47.
2012: Tiina Kelkka; Kutty Selva Nandakumar; Malin Hultqvist; Rikard Holmdahl
Enhancement of antibody-induced arthritis via Toll-like receptor 2 stimulation is regulated by granulocyte reactive oxygen species.
The American journal of pathology 2012;181(1):141-50.
2012: Angela Pizzolla; Brahm H Segal; Margareta Verdrengh; Tove Eneljung; Inger Gjertsson; Melissa J Grimm; Malin Hultqvist; Ing-Marie Jonsson; Tiina Kelkka; Bo Nilson; Rikard Holmdahl
Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(10):5003-11.
2012: Sabrina Haag; Jonatan Tuncel; Hüseyin Uysal; Johan Bäcklund; Rikard Holmdahl
Human α-enolase is immunogenic, but not arthritogenic, in HLA-DR4-transgenic mice: comment on the article by Kinloch et al.
Arthritis and rheumatism 2012;64(5):1689-91; author reply 1691-2.
2012: Tiina Kelkka; Mikko O Laukkanen; Juha Petteri Laurila; Peter Olofsson; Outi Sareila; Rikard Holmdahl
Superoxide dismutase 3 limits collagen-induced arthritis in the absence of phagocyte oxidative burst.
Mediators of inflammation 2012;2012():730469.
2012: Lina M Olsson; Sa C M Johansson; Anna-Karin Lindqvist; Patrik Medstrand; Annika Nerstedt; Peter Olofsson; Rikard Holmdahl
Copy number variation of the gene NCF1 is associated with rheumatoid arthritis.
Antioxidants & redox signaling 2012;16(1):71-8.
2011: Doreen Dobritzsch; Harald Burkhardt; Ingrid Lindh; Kutty Selva Nandakumar; Gunter Schneider; Hüseyin Uysal; Rikard Holmdahl
Crystal structure of an arthritogenic anticollagen immune complex.
Arthritis and rheumatism 2011;63(12):3740-8.
2011: Duojia Cao; Estelle Bajtner; Thomas Blom; Hongwei Jia; Ia Khmaladze; John A Mo; Kutty Selva Nandakumar; Rikard Holmdahl
Pathogenic autoreactive B cells are not negatively selected toward matrix protein collagen II.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(9):4451-8.
2011: Arvind Kumar Shakya; Kristin Hagenow; Rikard Holmdahl; Malin Hultqvist; Dorota Klaczkowska; Ashok Kumar; Kutty Selva Nandakumar
Collagen type II and a thermo-responsive polymer of N-isopropylacrylamide induce arthritis independent of Toll-like receptors: a strong influence by major histocompatibility complex class II and Ncf1 genes.
The American journal of pathology 2011;179(5):2490-500.
2011: Outi Sareila; Malin Hultqvist; Tiina Kelkka; Angela Pizzolla; Rikard Holmdahl
NOX2 complex-derived ROS as immune regulators.
Antioxidants & redox signaling 2011;15(8):2197-208.
2011: Dongmin Li; Hongmin Li; Yan Han; Rikard Holmdahl; Xi Lan; Juan Ren; Wuchao Ren; Tianbao Song; Feimiao Wang; Xuan Wang; Fujun Zhang; Shemin Lu
High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats.
Molecular and cellular endocrinology 2011;344(1-2):69-80.
2011: Ida E Andersson; Tsvetelina Batsalova; Balik Dzhambazov; Sabrina Haag; Rikard Holmdahl; Jan Kihlberg; Anna Linusson
(E)-alkene and ethylene isosteres substantially alter the hydrogen-bonding network in class II MHC A(q)/glycopeptide complexes and affect T-cell recognition.
Journal of the American Chemical Society 2011;133(36):14368-78.
2011: George Kollias; Iain McInnes; Piyi Papadaki; Ioannis Ragoussis; Georg Schett; Paul P Tak; Rene Toes; Wim van den Berg; Margriet J Vervoordeldonk; Wolfgang Wurst; Florence Apparailly; Vera Baumans; Christian Desaintes; James Di Santo; Jörg Distler; Paul Garside; Bert 't Hart; Martin Hegen; Rikard Holmdahl; Tom W J Huizinga; Astrid Jüngel; Lars Klareskog; Steffen Gay
Animal models for arthritis: innovative tools for prevention and treatment.
Annals of the rheumatic diseases 2011;70(8):1357-62.
2011: Emma Ahlqvist; Diana Ekman; Jonathan Flint; Michael Förster; Malin Hultqvist; Martina Johannesson; Dorota Klaczkowska; Therese Lindvall; Kutty Selva Nandakumar; Marjan Popovic; Ivanka Teneva; William Valdar; Rikard Holmdahl
High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice.
Human molecular genetics 2011;20(15):3031-41.
2011: Caroline Jochems; Ulrika Islander; Malin C Erlandsson; C Engdahl; Marie Lagerquist; Claes Ohlsson; Kutty Selva Nandakumar; Rikard Holmdahl; Hans Carlsten
Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis.
Clinical and experimental immunology 2011;165(1):121-9.
2011: Malin Hultqvist; Outi Sareila; Frederik Vilhardt; Ulrika Norin; Lina M Olsson; Peter Olofsson; Ulf Hellman; Rikard Holmdahl
Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats.
Antioxidants & redox signaling 2011;14(12):2373-83.
2011: Allyson M Croxford; Rikard Holmdahl; Don McNaughton; Mark J Tobin; Kutty Selva Nandakumar; Merrill J Rowley
Chemical changes demonstrated in cartilage by synchrotron infrared microspectroscopy in an antibody-induced murine model of rheumatoid arthritis.
Journal of biomedical optics 2011;16(6):066004.
2011: Therese Lindvall; Kutty Selva Nandakumar; Kimia Yousefi; Rikard Holmdahl; Asa Andersson
An encephalomyelitis-specific locus on chromosome 16 in mouse controls disease development and expression of immune-regulatory genes.
Journal of neuroimmunology 2011;235(1-2):40-7.
2011: Angela Pizzolla; Kyra A Gelderman; Malin Hultqvist; Mikael Vestberg; Kenth Gustafsson; Ragnar Mattsson; Rikard Holmdahl
CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species.
European journal of immunology 2011;41(2):403-12.
2011: Wenhua Zhu; Liesu Meng; Peng Xu; Heng Du; Xiaojing He; Rikard Holmdahl; Weikun Hou; Congshan Jiang; Shemin Lu
Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts.
Arthritis research & therapy 2011;13(3):R103.
2011: Alexandra Bäcklund; Anders Grubb; Katarina Håkansson; Meirav Holmdahl; Veronica Lindström; Ragnar Mattsson; Kutty Selva Nandakumar; Rikard Holmdahl
Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development.
Arthritis research & therapy 2011;13(2):R54.
2011: Ida E Andersson; C David Andersson; Tsvetelina Batsalova; Balik Dzhambazov; Rikard Holmdahl; Jan Kihlberg; Anna Linusson
Design of glycopeptides used to investigate class II MHC binding and T-cell responses associated with autoimmune arthritis.
PloS one 2011;6(3):e17881.
2011: Yawei Liu; Anna Teige; Emma Mondoc; Saleh Ibrahim; Rikard Holmdahl; Shohreh Issazadeh-Navikas
Endogenous collagen peptide activation of CD1d-restricted NKT cells ameliorates tissue-specific inflammation in mice.
The Journal of clinical investigation 2011;121(1):249-64.
2010: Allyson M Croxford; Duncan Crombie; Donald McNaughton; Rikard Holmdahl; Kutty Selva Nandakumar; Merrill J Rowley
Specific antibody protection of the extracellular cartilage matrix against collagen antibody-induced damage.
Arthritis and rheumatism 2010;62(11):3374-84.
2010: Marina D Kraaij; Nigel D L Savage; Sandra W van der Kooij; Karin Koekkoek; Jun Wang; J Merlijn van den Berg; Tom H M Ottenhoff; Taco W Kuijpers; Rikard Holmdahl; Cees van Kooten; Kyra A Gelderman
Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17686-91.
2010: Rikard Holmdahl
At last - rats lacking B cells.
European journal of immunology 2010;40(10):2680-1.
2010: Tsvetelina Batsalova; Balik Dzhambazov; Dorota Klaczkowska; Rikard Holmdahl
Mice producing less reactive oxygen species are relatively resistant to collagen glycopeptide vaccination against arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(5):2701-9.
2010: Malin Hultqvist; Kutty Selva Nandakumar; Ulf Björklund; Rikard Holmdahl
Rabeximod reduces arthritis severity in mice by decreasing activation of inflammatory cells.
Annals of the rheumatic diseases 2010;69(8):1527-32.
2010: Alan Gillett; Monica Marta; Tao Jin; Jonatan Tuncel; Patrick Leclerc; Rita Nohra; Stefan Lange; Rikard Holmdahl; Tomas Olsson; Robert A Harris; Maja Jagodic
TNF production in macrophages is genetically determined and regulates inflammatory disease in rats.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):442-50.
2010: Ida E Andersson; Tsvetelina Batsalova; Balik Dzhambazov; Lotta Edvinsson; Rikard Holmdahl; Jan Kihlberg; Anna Linusson
Oxazole-modified glycopeptides that target arthritis-associated class II MHC A(q) and DR4 proteins.
Organic & biomolecular chemistry 2010;8(13):2931-40.
2010: Nicholas C Van de Velde; Patricia L Mottram; Maree S Powell; Bock Lim; Rikard Holmdahl; P Mark Hogarth
Transgenic mice expressing human FcgammaRIIa have enhanced sensitivity to induced autoimmune arthritis as well as elevated Th17 cells.
Immunology letters 2010;130(1-2):82-8.
2010: Caroline Jochems; Ulrika Islander; Malin C Erlandsson; Cecilia Engdahl; Marie Lagerquist; Inger Gjertsson; Claes Ohlsson; Rikard Holmdahl; Hans Carlsten
Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis.
BMC musculoskeletal disorders 2010;11():284.
2010: Kutty Selva Nandakumar; Asa Jansson; Bingze Xu; Niclas Rydell; Parvin Ahooghalandari; Lars Hellman; Anna Blom; Rikard Holmdahl
A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis.
PloS one 2010;5(10):e13511.
2010: Liesu Meng; Wenhua Zhu; Congshan Jiang; Xiaojing He; Weikun Hou; Fang Zheng; Rikard Holmdahl; Shemin Lu
Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats.
Arthritis research & therapy 2010;12(3):R103.
2010: Hüseyin Uysal; Kutty Selva Nandakumar; Christoph Kessel; Sabrina Haag; Stefan Carlsen; Harald Burkhardt; Rikard Holmdahl
Antibodies to citrullinated proteins: molecular interactions and arthritogenicity.
Immunological reviews 2010;233(1):9-33.
2010: Omri Snir; Mona Widhe; Monika Hermansson; Caroline von Spee; Johan Lindberg; Sanne Hensen; Karin Lundberg; Ake Engström; Patrick J W Venables; René E M Toes; Rikard Holmdahl; Lars Klareskog; Vivianne Malmström
Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients.
Arthritis and rheumatism 2010;62(1):44-52.
2009: Xinhua Yu; Lena Wester-Rosenlöf; Ulrike Gimsa; Stephanie-Anna Holzhueter; Andreia Marques; Ludwig Jonas; Kristin Hagenow; Manfred Kunz; Horst Nizze; Markus Tiedge; Rikard Holmdahl; Saleh M Ibrahim
The mtDNA nt7778 G/T polymorphism affects autoimmune diseases and reproductive performance in the mouse.
Human molecular genetics 2009;18(24):4689-98.
2009: Anders Kielland; Thomas Blom; Kutty Selva Nandakumar; Rikard Holmdahl; Rune Blomhoff; Harald Carlsen
In vivo imaging of reactive oxygen and nitrogen species in inflammation using the luminescent probe L-012.
Free radical biology & medicine 2009;47(6):760-6.
2009: Balik Dzhambazov; Ingrid Lindh; Ake Engström; Rikard Holmdahl
Tissue transglutaminase enhances collagen type II-induced arthritis and modifies the immunodominant T-cell epitope CII260-270.
European journal of immunology 2009;39(9):2412-23.
2009: Maria Liljander; Asa Andersson; Rikard Holmdahl; Ragnar Mattsson
Increased litter size and super-ovulation rate in congenic C57BL mice carrying a polymorphic fragment of NFR/N origin at the Fecq4 locus of chromosome 9.
Genetics research 2009;91(4):259-65.
2009: Kristin Hagenow; Kyra A Gelderman; Malin Hultqvist; Patrick Merky; Johan Bäcklund; Oliver Frey; Thomas Kamradt; Rikard Holmdahl
Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):874-81.
2009: Malin Hultqvist; Lina M Olsson; Kyra A Gelderman; Rikard Holmdahl
The protective role of ROS in autoimmune disease.
Trends in immunology 2009;30(5):201-8.
2009: Alexander Huberle; Amennai Daniel Beyeen; Johan Ockinger; Miriam Ayturan; Maja Jagodic; Katrien L de Graaf; Nicolas Fissolo; Monica Marta; Peter Olofsson; Malin Hultqvist; Rikard Holmdahl; Tomas Olsson; Robert Weissert
Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4432-8.
2009: Cornelia Richter; Martina Herrero San Juan; Jutta Will; Ralf P Brandes; Ulrich Kalinke; Shizuo Akira; Josef M Pfeilschifter; Malin Hultqvist; Rikard Holmdahl; Heinfried Radeke
Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4183-91.
2009: Inger Gjertsson; Karen L Laurie; James Devitt; Steven J Howe; Adrian J Thrasher; Rikard Holmdahl; Kenth Gustafsson
Tolerance induction using lentiviral gene delivery delays onset and severity of collagen II arthritis.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(4):632-40.
2009: Hüseyin Uysal; Robert Bockermann; Kutty Selva Nandakumar; Bettina Sehnert; Estelle Bajtner; Ake Engström; Guy Serre; Harald Burkhardt; Marjolein M G M Thunnissen; Rikard Holmdahl
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
The Journal of experimental medicine 2009;206(2):449-62.
2009: Carola Rintisch; Michael Förster; Rikard Holmdahl
Detection of arthritis-susceptibility loci, including Ncf1, and variable effects of the major histocompatibility complex region depending on genetic background in rats.
Arthritis and rheumatism 2009;60(2):419-27.
2009: Therese Lindvall; Jenny Karlsson; Rikard Holmdahl; Asa Andersson
Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes.
Arthritis research & therapy 2009;11(1):R10.
2009: Emma Ahlqvist; Malin Hultqvist; Rikard Holmdahl
The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.
Arthritis research & therapy 2009;11(3):226.
2009: Martina Johannesson; Regina Lopez-Aumatell; Pernilla Stridh; Margarita Diez; Jonatan Tuncel; Gloria Blázquez; Esther Martinez-Membrives; Toni Cañete; Elia Vicens-Costa; Delyth Graham; Richard R Copley; Polinka Hernandez-Pliego; Amennai D Beyeen; Johan Ockinger; Cristina Fernández-Santamaría; Percio S Gulko; Max Brenner; Adolf Tobeña; Marc Guitart-Masip; Lydia Giménez-Llort; Anna Dominiczak; Rikard Holmdahl; Dominique Gauguier; Tomas Olsson; Richard Mott; William Valdar; Eva E Redei; Alberto Fernández-Teruel; Jonathan Flint
A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock.
Genome research 2009;19(1):150-8.
2008: Ulrika Böiers; Harald Lanig; Bettina Sehnert; Rikard Holmdahl; Harald Burkhardt
Collagen type II is recognized by a pathogenic antibody through germline encoded structures.
European journal of immunology 2008;38(10):2784-95.
2008: M Popovic; E Ahlqvist; E Rockenbauer; Robert Bockermann; Rikard Holmdahl
Identification of new loci controlling collagen-induced arthritis in mouse using a partial advanced intercross and congenic strains.
Scandinavian journal of immunology 2008;68(4):405-13.
2008: Carola Rintisch; Jacqueline Ameri; Peter Olofsson; Holger Luthman; Rikard Holmdahl
Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):14005-10.
2008: Suthasinee Nilsang; Vishal Nehru; Fatima M Plieva; Kutty Selva Nandakumar; Sudip Kumar Rakshit; Rikard Holmdahl; Bo Mattiasson; Ashok Kumar
Three-dimensional culture for monoclonal antibody production by hybridoma cells immobilized in macroporous gel particles.
Biotechnology progress 2008;24(5):1122-31.
2008: Meirav Holmdahl; Stefan R Ahlfors; Rikard Holmdahl; Christer Hansson
Structure-immune response relationships of hapten-modified collagen II peptides in a T-cell model of allergic contact dermatitis.
Chemical research in toxicology 2008;21(8):1514-23.
2008: Stefan Carlsen; Kutty Selva Nandakumar; Johan Bäcklund; Johan Holmberg; Malin Hultqvist; Mikael Vestberg; Rikard Holmdahl
Cartilage oligomeric matrix protein induction of chronic arthritis in mice.
Arthritis and rheumatism 2008;58(7):2000-11.
2008: Rikard Holmdahl
IL-21 and autoimmune disease--hypothesis and reality?
European journal of immunology 2008;38(7):1800-2.
2008: Carola Rintisch; Rikard Holmdahl
DA rats from two colonies differ genetically and in their arthritis susceptibility.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(6):420-8.
2008: Yumiko Imai; Keiji Kuba; G Greg Neely; Rubina Yaghubian-Malhami; Thomas Perkmann; Geert van Loo; Maria Ermolaeva; Ruud Veldhuizen; Y H Connie Leung; Hongliang Wang; Haolin Liu; Yang Sun; Manolis Pasparakis; Manfred Kopf; Christin Mech; Sina Bavari; J S M Peiris; Arthur Slutsky; Shizuo Akira; Malin Hultqvist; Rikard Holmdahl; John Nicholls; Chengyu Jiang; Christoph J Binder; Josef M Penninger
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Cell 2008;133(2):235-49.
2008: Honglin Wang; Daniel Kess; Anna-Karin B Lindqvist; Thorsten Peters; Anca Sindrilaru; Meinhard Wlaschek; Robert Blakytny; Rikard Holmdahl; Karin Scharffetter-Kochanek
A 9-centimorgan interval of chromosome 10 controls the T cell-dependent psoriasiform skin disease and arthritis in a murine psoriasis model.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(8):5520-9.
2008: Kutty Selva Nandakumar; Rikard Holmdahl
Therapeutic cleavage of IgG: new avenues for treating inflammation.
Trends in immunology 2008;29(4):173-8.
2008: Hüseyin Uysal; Bettina Sehnert; Kutty Selva Nandakumar; Ulrika Böiers; Harald Burkhardt; Rikard Holmdahl; Marjolein M G M Thunnissen
The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: structure to function analysis.
Molecular immunology 2008;45(8):2196-204.
2008: Hui Geng; Stefan Carlsen; Kutty Selva Nandakumar; Rikard Holmdahl; Anders Aspberg; Ake Oldberg; Ragnar Mattsson
Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis.
Arthritis research & therapy 2008;10(6):R134.
2008: Maria Liljander; Asa Andersson; Rikard Holmdahl; Ragnar Mattsson
Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments.
Arthritis research & therapy 2008;10(4):R88.
2008: Merrill J Rowley; Kutty Selva Nandakumar; Rikard Holmdahl
The role of collagen antibodies in mediating arthritis.
Modern rheumatology / the Japan Rheumatism Association 2008;18(5):429-41.
2008: Kutty Selva Nandakumar; Estelle Bajtner; Leigh Hill; Beate Böhm; Merrill J Rowley; Harald Burkhardt; Rikard Holmdahl
Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation.
Arthritis and rheumatism 2008;58(1):184-96.
2008: Marie Lagerquist; Malin C Erlandsson; Ulrika Islander; Lennart Svensson; Rikard Holmdahl; Hans Carlsten
17Beta-estradiol expands IgA-producing B cells in mice deficient for the mu chain.
Scandinavian journal of immunology 2008;67(1):12-7.
2007: Markus H Hoffmann; Jonatan Tuncel; Karl Skriner; Makiyeh Tohidast-Akrad; Birgit Türk; Serafin Pinol-Roma; Guy Serre; Georg Schett; Josef S Smolen; Rikard Holmdahl; Günter Steiner
The rheumatoid arthritis-associated autoantigen hnRNP-A2 (RA33) is a major stimulator of autoimmunity in rats with pristane-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7568-76.
2007: Ida E Andersson; Balik Dzhambazov; Rikard Holmdahl; Anna Linusson; Jan Kihlberg
Probing molecular interactions within class II MHC Aq/glycopeptide/T-cell receptor complexes associated with collagen-induced arthritis.
Journal of medicinal chemistry 2007;50(23):5627-43.
2007: Kyra A Gelderman; Malin Hultqvist; Angela Pizzolla; Ming Zhao; Kutty Selva Nandakumar; Ragnar Mattsson; Rikard Holmdahl
Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species.
The Journal of clinical investigation 2007;117(10):3020-8.
2007: Kutty Selva Nandakumar; Björn P Johansson; Lars Björck; Rikard Holmdahl
Blocking of experimental arthritis by cleavage of IgG antibodies in vivo.
Arthritis and rheumatism 2007;56(10):3253-60.
2007: Kutty Selva Nandakumar; Mattias Collin; Arne Olsén; Falk Nimmerjahn; Anna M Blom; Jeffrey V Ravetch; Rikard Holmdahl
Endoglycosidase treatment abrogates IgG arthritogenicity: importance of IgG glycosylation in arthritis.
European journal of immunology 2007;37(10):2973-82.
2007: Kyra A Gelderman; Malin Hultqvist; Lina M Olsson; Kristin Bauer; Angela Pizzolla; Peter Olofsson; Rikard Holmdahl
Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies.
Antioxidants & redox signaling 2007;9(10):1541-67.
2007: Malin Hultqvist; Johan Bäcklund; Kristin Bauer; Kyra A Gelderman; Rikard Holmdahl
Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(3):1431-7.
2007: Suthasinee Nilsang; Kutty Selva Nandakumar; Igor Yu Galaev; Sudip Kumar Rakshit; Rikard Holmdahl; Bo Mattiasson; Ashok Kumar
Monoclonal antibody production using a new supermacroporous cryogel bioreactor.
Biotechnology progress 2007;23(4):932-9.
2007: Lotta Holm; Kristina Frech; Balik Dzhambazov; Rikard Holmdahl; Jan Kihlberg; Anna Linusson
Quantitative structure-activity relationship of peptides binding to the class II major histocompatibility complex molecule Aq associated with autoimmune arthritis.
Journal of medicinal chemistry 2007;50(9):2049-59.
2007: Alexei von Delwig; Daniel M Altmann; Fraser G Charlton; Norman McKie; John D Isaacs; Rikard Holmdahl; John Robinson
T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic mice.
Annals of the rheumatic diseases 2007;66(5):599-604.
2007: Rikard Holmdahl
Aire-ing self antigen variability and tolerance.
European journal of immunology 2007;37(3):598-601.
2007: Emma Ahlqvist; Robert Bockermann; Rikard Holmdahl
Fragmentation of two quantitative trait loci controlling collagen-induced arthritis reveals a new set of interacting subloci.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3084-90.
2007: Rikard Holmdahl
Primer: comparative genetics of animal models of arthritis--a tool to resolve complexity.
Nature clinical practice. Rheumatology 2007;3(2):104-11.
2007: Robert Bockermann; Rikard Holmdahl
Type II collagen without adjuvant induces eosinophilic arthritis.
European journal of immunology 2007;37(2):540-8.
2007: Ing-Marie Jonsson; Margareta Verdrengh; Mikael Brisslert; Sofia Lindblad; Maria Bokarewa; Ulrika Islander; Hans Carlsten; Claes Ohlsson; Kutty Selva Nandakumar; Rikard Holmdahl; Andrej Tarkowski
Ethanol prevents development of destructive arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):258-63.
2007: Peter Olofsson; Rikard Holmdahl
Pristane-induced arthritis in the rat.
Methods in molecular medicine 2007;136():255-68.
2007: Stefan Carlsen; Shemin Lu; Rikard Holmdahl
Arthritis induced with minor cartilage proteins.
Methods in molecular medicine 2007;136():225-42.
2007: Kutty Selva Nandakumar; Rikard Holmdahl
Collagen antibody induced arthritis.
Methods in molecular medicine 2007;136():215-23.
2007: Rikard Holmdahl
The use of animal models for rheumatoid arthritis.
Methods in molecular medicine 2007;136():185-9.
2007: Trond Ove R Hjelmervik; Anna-Karin Lindqvist; Kjell Petersen; Martina Johannesson; Anne-Kristin Stavrum; Asa Johansson; Roland Jonsson; Rikard Holmdahl; Anne Isine Bolstad
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice.
Arthritis research & therapy 2007;9(5):R99.
2007: Lina M Olsson; Anna-Karin Lindqvist; Henrik Källberg; Leonid Padyukov; Harald Burkhardt; Lars Alfredsson; Lars Klareskog; Rikard Holmdahl
A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.
Arthritis research & therapy 2007;9(5):R98.
2007: Marcin Okroj; Dick Heinegård; Rikard Holmdahl; Anna Blom
Rheumatoid arthritis and the complement system.
Annals of medicine 2007;39(7):517-30.
2007: Peter Olofsson; Annika Nerstedt; Malin Hultqvist; Elisabeth C Nilsson; Sofia Andersson; Anna Bergelin; Rikard Holmdahl
Arthritis suppression by NADPH activation operates through an interferon-beta pathway.
BMC biology 2007;5():19.
2006: Daniel Kess; Anna-Karin B Lindqvist; Thorsten Peters; Honglin Wang; Jan Zamek; Roswitha Nischt; Karl W Broman; Robert Blakytny; Thomas Krieg; Rikard Holmdahl; Karin Scharffetter-Kochanek
Identification of susceptibility loci for skin disease in a murine psoriasis model.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(7):4612-9.
2006: Anna-Karin B Lindqvist; Martina Johannesson; Ann-Cathrine Johansson; Kutty Selva Nandakumar; Anna M Blom; Rikard Holmdahl
Backcross and partial advanced intercross analysis of nonobese diabetic gene-mediated effects on collagen-induced arthritis reveals an interactive effect by two major loci.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):3952-9.
2006: Malin Hultqvist; Peter Olofsson; Kyra A Gelderman; Jens Holmberg; Rikard Holmdahl
A new arthritis therapy with oxidative burst inducers.
PLoS medicine 2006;3(9):e348.
2006: Lotta Holm; Robert Bockermann; Erik Wellner; Johan Bäcklund; Rikard Holmdahl; Jan Kihlberg
Side-chain and backbone amide bond requirements for glycopeptide stimulation of T-cells obtained in a mouse model for rheumatoid arthritis.
Bioorganic & medicinal chemistry 2006;14(17):5921-32.
2006: Kyra A Gelderman; Malin Hultqvist; Jens Holmberg; Peter Olofsson; Rikard Holmdahl
T cell surface redox levels determine T cell reactivity and arthritis susceptibility.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(34):12831-6.
2006: Kutty Selva Nandakumar; Rikard Holmdahl
Arthritis induced with cartilage-specific antibodiesis IL-4-dependent.
European journal of immunology 2006;36(6):1608-18.
2006: Maria Liljander; Mary-Ann Sällström; Sara Andersson; Patrik Wernhoff; Asa Andersson; Rikard Holmdahl; Ragnar Mattsson
Identification of genetic regions of importance for reproductive performance in female mice.
Genetics 2006;173(2):901-9.
2006: Kristina Becanovic; Maja Jagodic; Jianrong Sheng; Ingrid Dahlman; Fahmy Aboul-Enein; Erik Wallstrom; Peter Olofsson; Rikard Holmdahl; Hans Lassmann; Tomas Olsson
Advanced intercross line mapping of Eae5 reveals Ncf-1 and CLDN4 as candidate genes for experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(10):6055-64.
2006: Rikard Holmdahl
Dissection of the genetic complexity of arthritis using animal models.
Immunology letters 2006;103(2):86-91.
2006: Ashok Kumar; Vibha Bansal; Kutty Selva Nandakumar; Igor Yu Galaev; Pradip K Roychoudhury; Rikard Holmdahl; Bo Mattiasson
Integrated bioprocess for the production and isolation of urokinase from animal cell culture using supermacroporous cryogel matrices.
Biotechnology and bioengineering 2006;93(4):636-46.
2006: Alexei von Delwig; Daniel M Altmann; John D Isaacs; Clifford V Harding; Rikard Holmdahl; Norman McKie; John Robinson
The impact of glycosylation on HLA-DR1-restricted T cell recognition of type II collagen in a mouse model.
Arthritis and rheumatism 2006;54(2):482-91.
2006: Balik Dzhambazov; Kutty Selva Nandakumar; Jan Kihlberg; Lars Fugger; Rikard Holmdahl; Mikael Vestberg
Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1525-33.
2006: Jens Holmberg; Jonatan Tuncel; Hisakata Yamada; Shemin Lu; Peter Olofsson; Rikard Holmdahl
Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(2):1172-9.
2006: Kutty Selva Nandakumar; Rikard Holmdahl
Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis.
Arthritis research & therapy 2006;8(6):223.
2006: Stefan Carlsen; Kutty Selva Nandakumar; Rikard Holmdahl
Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity.
Arthritis research & therapy 2006;8(4):R102.
2006: Bettina Sehnert; Philip Gierer; Saleh Ibrahim; Anja Kühl; Reinhard E Voll; Kutty Selva Nandakumar; Rikard Holmdahl; Rupert Hallmann; Brigitte Vollmar; Harald Burkhardt
Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium.
Arthritis research & therapy 2006;8(4):R95.
2006: M Johannesson; Malin Hultqvist; Rikard Holmdahl
Genetics of autoimmune diseases: a multistep process.
Current topics in microbiology and immunology 2006;305():259-76.
2006: Alexei von Delwig; Catharien M U Hilkens; Daniel M Altmann; Rikard Holmdahl; John D Isaacs; Clifford V Harding; Helen Robertson; Norman McKie; John Robinson
Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice.
Arthritis research & therapy 2006;8(4):R93.
2006: Maria Liljander; Mary-Ann Sällström; Sara Andersson; Asa Andersson; Rikard Holmdahl; Ragnar Mattsson
Identification of collagen-induced arthritis loci in aged multiparous female mice.
Arthritis research & therapy 2006;8(2):R45.
2006: Harald Burkhardt; Ulrike Hüffmeier; Bernd M Spriewald; Beate Böhm; Rolf Rau; Stefan Kallert; Ake Engström; Rikard Holmdahl; André Reis
Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis.
Arthritis and rheumatism 2006;54(1):82-9.
2005: Alexandra Treschow Bäcklund; Ingrid Teige; Kutty Selva Nandakumar; Rikard Holmdahl; Shohreh Issazadeh-Navikas
Stromal cells and osteoclasts are responsible for exacerbated collagen-induced arthritis in interferon-beta-deficient mice.
Arthritis and rheumatism 2005;52(12):3739-48.
2005: M Johannesson; L M Olsson; Anna-Karin B Lindqvist; S Möller; Dirk Koczan; L Wester-Rosenlöf; H-J Thiesen; S Ibrahim; Rikard Holmdahl
Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.
Genes and immunity 2005;6(7):575-83.
2005: Hillary Crandall; Ying Ma; Diane M Dunn; Rhianna S Sundsbak; James F Zachary; Peter Olofsson; Rikard Holmdahl; John H Weis; Robert B Weiss; Cory Teuscher; Janis J Weis
Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase.
The American journal of pathology 2005;167(3):775-85.
2005: Kutty Selva Nandakumar; Rikard Holmdahl
Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis.
Journal of immunological methods 2005;304(1-2):126-36.
2005: Jinan Li; Yongzhi Guo; Rikard Holmdahl; Tor Ny
Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.
Arthritis and rheumatism 2005;52(8):2541-8.
2005: S Fatemah Amirahmadi; Senga Whittingham; Duncan Crombie; Kutty Selva Nandakumar; Rikard Holmdahl; Ian R Mackay; Marie-Paule Van Damme; Merrill J Rowley
Arthritogenic anti-type II collagen antibodies are pathogenic for cartilage-derived chondrocytes independent of inflammatory cells.
Arthritis and rheumatism 2005;52(6):1897-906.
2005: Alexandra Treschow Bäcklund; Johan Bäcklund; Rikard Holmdahl; Shohreh Issazadeh-Navikas
Intrinsic tolerance in autologous collagen-induced arthritis is generated by CD152-dependent CD4+ suppressor cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(11):6742-50.
2005: Asa Andersson; Rikard Holmdahl
A genetic basis for shared autoimmunity in mouse models.
Autoimmunity 2005;38(3):209-17.
2005: Harald Burkhardt; Bettina Sehnert; Robert Bockermann; Ake Engström; Joachim R Kalden; Rikard Holmdahl
Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis.
European journal of immunology 2005;35(5):1643-52.
2005: M Johannesson; J Karlsson; Patrik Wernhoff; Kutty Selva Nandakumar; Anna-Karin B Lindqvist; L Olsson; A D Cook; A Andersson; Rikard Holmdahl
Identification of epistasis through a partial advanced intercross reveals three arthritis loci within the Cia5 QTL in mice.
Genes and immunity 2005;6(3):175-85.
2005: Kutty Selva Nandakumar; Rikard Holmdahl
A genetic contamination in MHC-congenic mouse strains reveals a locus on chromosome 10 that determines autoimmunity and arthritis susceptibility.
European journal of immunology 2005;35(4):1275-82.
2005: Franziska Lange; Estelle Bajtner; C Rintisch; Kutty Selva Nandakumar; Ulrich Sack; Rikard Holmdahl
Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis.
Annals of the rheumatic diseases 2005;64(4):599-605.
2005: Jinan Li; Annelii Ny; Göran Leonardsson; Kutty Selva Nandakumar; Rikard Holmdahl; Tor Ny
The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis.
The American journal of pathology 2005;166(3):783-92.
2005: Malin Hultqvist; Rikard Holmdahl
Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.
Cellular immunology 2005;233(2):97-101.
2005: Anna-Karin B Lindqvist; Britt Nakken; Martin Sundler; P Kjellén; Roland Jonsson; Rikard Holmdahl; Kathrine Skarstein
Influence on spontaneous tissue inflammation by the major histocompatibility complex region in the nonobese diabetic mouse.
Scandinavian journal of immunology 2005;61(2):119-27.
2005: Balik Dzhambazov; Meirav Holmdahl; Hisakata Yamada; Shemin Lu; Mikael Vestberg; Björn Holm; Olof Johnell; Jan Kihlberg; Rikard Holmdahl
The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans.
European journal of immunology 2005;35(2):357-66.
2005: Lotta Holm; Peter Kjellén; Rikard Holmdahl; Jan Kihlberg
Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis.
Bioorganic & medicinal chemistry 2005;13(2):473-82.
2005: Robert Bockermann; David Schubert; Thomas Kamradt; Rikard Holmdahl
Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase.
Arthritis research & therapy 2005;7(6):R1316-24.
2005: Duncan Crombie; Muhammed Turer; Beltzane Biurrun Zuasti; Bayden Wood; Don McNaughton; Kutty Selva Nandakumar; Rikard Holmdahl; Marie-Paule Van Damme; Merrill J Rowley
Destructive effects of murine arthritogenic antibodies to type II collagen on cartilage explants in vitro.
Arthritis research & therapy 2005;7(5):R927-37.
2005: Estelle Bajtner; Kutty Selva Nandakumar; Ake Engström; Rikard Holmdahl
Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen.
Arthritis research & therapy 2005;7(5):R1148-57.
2005: Kristin Bauer; Annika Knipper; Dirk Koczan; Hans Jürgen Kreutzer; Horst Nizze; Eilhard Mix; Hans-Jürgen Thiesen; Rikard Holmdahl; Hoang Tu-Rapp; Saleh M Ibrahim
Perforin deficiency attenuates collagen-induced arthritis.
Arthritis research & therapy 2005;7(4):R877-84.
2005: Jenny Karlsson; Martina Johannesson; Therese Lindvall; Patrik Wernhoff; Rikard Holmdahl; Asa Andersson
Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):533-41.
2005: Ashok Kumar; Arancha Rodríguez-Caballero; Fatima M Plieva; Igor Yu Galaev; Kutty Selva Nandakumar; Masamichi Kamihira; Rikard Holmdahl; Alberto Orfao; Bo Mattiasson
Affinity binding of cells to cryogel adsorbents with immobilized specific ligands: effect of ligand coupling and matrix architecture.
Journal of molecular recognition : JMR 2005;18(1):84-93.
2004: Pia Svendsen; Claus B Andersen; Nick Willcox; Anthony J Coyle; Rikard Holmdahl; Thomas Kamradt; Lars Fugger
Tracking of proinflammatory collagen-specific T cells in early and late collagen-induced arthritis in humanized mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(11):7037-45.
2004: Hisakata Yamada; Balik Dzhambazov; Robert Bockermann; Thomas Blom; Rikard Holmdahl
A transient post-translationally modified form of cartilage type II collagen is ignored by self-reactive T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4729-35.
2004: Malin Hultqvist; Peter Olofsson; Jens Holmberg; B Thomas Bäckström; Jesper Tordsson; Rikard Holmdahl
Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12646-51.
2004: Bettina Sehnert; Andrea Cavcic; Beate Böhm; Joachim R Kalden; Kutty Selva Nandakumar; Rikard Holmdahl; Harald Burkhardt
Antileukoproteinase: modulation of neutrophil function and therapeutic effects on anti-type II collagen antibody-induced arthritis.
Arthritis and rheumatism 2004;50(7):2347-59.
2004: Yuekang Xu; Paul Ramsland; Janet M Davies; Marita Scealy; Kutty Selva Nandakumar; Rikard Holmdahl; Merrill J Rowley
Two monoclonal antibodies to precisely the same epitope of type II collagen select non-crossreactive phage clones by phage display: implications for autoimmunity and molecular mimicry.
Molecular immunology 2004;41(4):411-9.
2004: Meirav Holmdahl; Anders Grubb; Rikard Holmdahl
Cysteine proteases in Langerhans cells limits presentation of cartilage derived type II collagen for autoreactive T cells.
International immunology 2004;16(5):717-26.
2004: Peter Olofsson; Asa Johansson; Dirk Wedekind; Ingrid Klöting; Karin Klinga-Levan; Shemin Lu; Rikard Holmdahl
Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1.
Genomics 2004;83(5):765-71.
2004: Max Albert Hietala; Kutty Selva Nandakumar; Linda Persson; Susann Fahlén; Rikard Holmdahl; Marcela Pekna
Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis.
European journal of immunology 2004;34(4):1208-16.
2004: Ann-Sofie Hansson; Martina Johannesson; Lars Svensson; Kutty Selva Nandakumar; Dick Heinegård; Rikard Holmdahl
Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease.
The American journal of pathology 2004;164(3):959-66.
2004: Jason C Huang; Mikael Vestberg; Alfredo Minguela; Rikard Holmdahl; E Sally Ward
Analysis of autoreactive T cells associated with murine collagen-induced arthritis using peptide-MHC multimers.
International immunology 2004;16(2):283-93.
2004: B Rostrom; A Grubb; Rikard Holmdahl
Oligoclonal IgG bands synthesized in the central nervous system are present in rats with experimental autoimmune encephalomyelitis.
Acta neurologica Scandinavica 2004;109(2):106-12.
2004: Kutty Selva Nandakumar; Johan Bäcklund; Mikael Vestberg; Rikard Holmdahl
Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells.
Arthritis research & therapy 2004;6(6):R544-50.
2004: Ann-Sofie Hansson; Ann-Cathrine Johansson; Rikard Holmdahl
Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice.
Arthritis research & therapy 2004;6(5):R484-91.
2004: Anna Teige; Ingrid Teige; Shahram Lavasani; Robert Bockermann; Emma Mondoc; Rikard Holmdahl; Shohreh Issazadeh-Navikas
CD1-dependent regulation of chronic central nervous system inflammation in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):186-94.
2003: Patrik Wernhoff; Peter Olofsson; Rikard Holmdahl
The genetic control of rheumatoid factor production in a rat model of rheumatoid arthritis.
Arthritis and rheumatism 2003;48(12):3584-96.
2003: Lena Wester; Peter Olofsson; Saleh M Ibrahim; Rikard Holmdahl
Chronicity of pristane-induced arthritis in rats is controlled by genes on chromosome 14.
Journal of autoimmunity 2003;21(4):305-13.
2003: Peter Olofsson; Patrik Wernhoff; Jens Holmberg; Rikard Holmdahl
Two-loci interaction confirms arthritis-regulating quantitative trait locus on rat chromosome 6.
Genomics 2003;82(6):652-9.
2003: Kutty Selva Nandakumar; Lars Svensson; Rikard Holmdahl
Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes.
The American journal of pathology 2003;163(5):1827-37.
2003: Johan Bäcklund; Kutty Selva Nandakumar; Robert Bockermann; Lucia Mori; Rikard Holmdahl
Genetic control of tolerance to type II collagen and development of arthritis in an autologous collagen-induced arthritis model.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3493-9.
2003: Rikard Holmdahl
Dissection of the genetic complexity of arthritis using animal models.
Journal of autoimmunity 2003;21(2):99-103.
2003: Björn Holm; Syed M Baquer; Lotta Holm; Rikard Holmdahl; Jan Kihlberg
Role of the galactosyl moiety of collagen glycopeptides for T-cell stimulation in a model for rheumatoid arthritis.
Bioorganic & medicinal chemistry 2003;11(18):3981-7.
2003: Margareta Verdrengh; Ing-Marie Jonsson; Rikard Holmdahl; Andrej Tarkowski
Genistein as an anti-inflammatory agent.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2003;52(8):341-6.
2003: Peter Olofsson; Shemin Lu; Jens Holmberg; Tusheng Song; Patrik Wernhoff; Ulf Pettersson; Rikard Holmdahl
A comparative genetic analysis between collagen-induced arthritis and pristane-induced arthritis.
Arthritis and rheumatism 2003;48(8):2332-42.
2003: Kutty Selva Nandakumar; Maria Andrén; Pernilla Martinsson; Estelle Bajtner; Silvia Hellström; Rikard Holmdahl; Sandra Kleinau
Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB.
European journal of immunology 2003;33(8):2269-77.
2003: Peter Olofsson; Rikard Holmdahl
Positional cloning of Ncf1--a piece in the puzzle of arthritis genetics.
Scandinavian journal of immunology 2003;58(2):155-64.
2003: Peter Olofsson; Jens Holmberg; Ulf Pettersson; Rikard Holmdahl
Identification and isolation of dominant susceptibility loci for pristane-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):407-16.
2003: Ingrid Teige; Alexandra Treschow Bäcklund; Anna Teige; Ragnar Mattsson; Vaidrius Navikas; Tomas Leanderson; Rikard Holmdahl; Shohreh Issazadeh-Navikas
IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4776-84.
2003: Lena Mölne; A Corthay; Rikard Holmdahl; Andrej Tarkowski
Role of gamma/delta T cell receptor-expressing lymphocytes in cutaneous infection caused by Staphylococcus aureus.
Clinical and experimental immunology 2003;132(2):209-15.
2003: Thomas Blom; Ahnders Franzén; Dick Heinegård; Rikard Holmdahl
Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease".
Science (New York, N.Y.) 2003;299(5614):1845; author reply 1845.
2003: Ann-Cathrine Johansson; Anna-Karin B Lindqvist; Martina Johannesson; Rikard Holmdahl
Genetic heterogeneity of autoimmune disorders in the nonobese diabetic mouse.
Scandinavian journal of immunology 2003;57(3):203-13.
2003: Kristina Becanovic; Erik Wallstrom; Barbara Kornek; Anna Glaser; Karl W Broman; Ingrid Dahlman; Peter Olofsson; Rikard Holmdahl; Holger Luthman; Hans Lassmann; Tomas Olsson
New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):1062-9.
2003: Jenny Karlsson; Xiangshan Zhao; Irina Lonskaya; Malin Neptin; Rikard Holmdahl; Asa Andersson
Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(2):1019-26.
2003: Lena Wester; Dirk Koczan; Jens Holmberg; Peter Olofsson; Hans-Jürgen Thiesen; Rikard Holmdahl; Saleh Ibrahim
Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats.
Arthritis research & therapy 2003;5(6):R361-72.
2003: Peter Olofsson; Jens Holmberg; Jesper Tordsson; Shemin Lu; Bo Akerström; Rikard Holmdahl
Positional identification of Ncf1 as a gene that regulates arthritis severity in rats.
Nature genetics 2003;33(1):25-32.
2002: Björn Holm; Johan Bäcklund; Miguel A F Recio; Rikard Holmdahl; Jan Kihlberg
Glycopeptide specificity of helper T cells obtained in mouse models for rheumatoid arthritis.
Chembiochem : a European journal of chemical biology 2002;3(12):1209-22.
2002: Johan Bäcklund; Alexandra Treschow Bäcklund; Robert Bockermann; Björn Holm; Lotta Holm; Shohreh Issazadeh-Navikas; Jan Kihlberg; Rikard Holmdahl
Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis.
European journal of immunology 2002;32(12):3776-84.
2002: Lars Svensson; Kutty Selva Nandakumar; Asa Johansson; Liselotte Jansson; Rikard Holmdahl
IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis.
European journal of immunology 2002;32(10):2944-53.
2002: Harald Burkhardt; Tobias Koller; Ake Engström; Kutty Selva Nandakumar; Javier Turnay; Hans G Kraetsch; Joachim R Kalden; Rikard Holmdahl
Epitope-specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen-induced arthritis in the mouse.
Arthritis and rheumatism 2002;46(9):2339-48.
2002: Margareta Verdrengh; Ing-Marie Jonsson; O Zaether; E Bajtner; Rikard Holmdahl; Andrej Tarkowski
Total abrogation of collagen II-induced arthritis and the B cell response to type II collagen using suboptimal doses of a topoisomerase II antagonist.
Annals of the rheumatic diseases 2002;61(9):829-31.
2002: Shemin Lu; Niklas Nordquist; Jens Holmberg; Peter Olofsson; Ulf Pettersson; Rikard Holmdahl
Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis.
European journal of human genetics : EJHG 2002;10(8):475-83.
2002: Johan Bäcklund; Stefan Carlsen; Torsten Höger; Björn Holm; Lars Fugger; Jan Kihlberg; Harald Burkhardt; Rikard Holmdahl
Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):9960-5.
2002: Per Levéen; Jonas Larsson; Mats Ehinger; Corrado M Cilio; Martin Sundler; Lottie Jansson Sjöstrand; Rikard Holmdahl; Stefan Karlsson
Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable.
Blood 2002;100(2):560-8.
2002: Lars Svensson; Khairul-Bariah Abdul-Majid; Jan Bauer; Hans Lassmann; Robert A Harris; Rikard Holmdahl
A comparative analysis of B cell-mediated myelin oligodendrocyte glycoprotein-experimental autoimmune encephalomyelitis pathogenesis in B cell-deficient mice reveals an effect on demyelination.
European journal of immunology 2002;32(7):1939-46.
2002: Johan Bäcklund; Alexandra Treschow Bäcklund; Mihail Firan; Vivianne Malmström; Shohreh Issazadeh-Navikas; E Sally Ward; Rikard Holmdahl
Reversal of tolerance induced by transplantation of skin expressing the immunodominant T cell epitope of rat type II collagen entitles development of collagen-induced arthritis but not graft rejection.
European journal of immunology 2002;32(6):1773-83.
2002: Shemin Lu; Stefan Carlsen; Ann Sofie Hansson; Rikard Holmdahl
Immunization of rats with homologous type XI collagen leads to chronic and relapsing arthritis with different genetics and joint pathology than arthritis induced with homologous type II collagen.
Journal of autoimmunity 2002;18(3):199-211.
2002: Lars Råberg; Mikael Vestberg; Dennis Hasselquist; Rikard Holmdahl; Erik Svensson; Jan-Ake Nilsson
Basal metabolic rate and the evolution of the adaptive immune system.
Proceedings. Biological sciences / The Royal Society 2002;269(1493):817-21.
2002: M Holmdahl; Mikael Vestberg; Rikard Holmdahl
Primed B cells present type-II collagen to T cells.
Scandinavian journal of immunology 2002;55(4):382-9.
2002: Rikard Holmdahl; Robert Bockermann; Johan Bäcklund; Hisakata Yamada
The molecular pathogenesis of collagen-induced arthritis in mice--a model for rheumatoid arthritis.
Ageing research reviews 2002;1(1):135-47.
2002: Ann-Sofie Hansson; Rikard Holmdahl
Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis.
Arthritis research 2002;4(5):296-301.
2002: A-S Hansson; Shemin Lu; Rikard Holmdahl
Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models.
Clinical and experimental immunology 2002;127(1):37-42.
2002: Peter Olofsson; Niklas Nordquist; Carina Vingsbo-Lundberg; Anders Larsson; Cecilia Falkenberg; Ulf Pettersson; Bo Akerström; Rikard Holmdahl
Genetic links between the acute-phase response and arthritis development in rats.
Arthritis and rheumatism 2002;46(1):259-68.
2002: Ann-Cathrine Johansson; Britt Nakken; Martin Sundler; Anna-Karin B Lindqvist; Martina Johannesson; Marta E Alarcón-Riquelme; Anne Isine Bolstad; Michael G Humphreys-Beher; Roland Jonsson; Kathrine Skarstein; Rikard Holmdahl
The genetic control of sialadenitis versus arthritis in a NOD.QxB10.Q F2 cross.
European journal of immunology 2002;32(1):243-50.
2002: Johan Jirholt; Anna-Karin Lindqvist; Jenny Karlsson; Asa Andersson; Rikard Holmdahl
Identification of susceptibility genes for experimental autoimmune encephalomyelitis that overcome the effect of protective alleles at the eae2 locus.
International immunology 2002;14(1):79-85.
2001: Rikard Holmdahl; J C Lorentzen; Shemin Lu; P Olofsson; Lena Wester; Jens Holmberg; U Pettersson
Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis.
Immunological reviews 2001;184():184-202.
2001: Peter Kjellén; L Jansson; Mikael Vestberg; A Andersson; R Mattsson; Rikard Holmdahl
The H2-Ab gene influences the severity of experimental allergic encephalomyelitis induced by proteolipoprotein peptide 103-116.
Journal of neuroimmunology 2001;120(1-2):25-33.
2001: A Corthay; Johan Bäcklund; Rikard Holmdahl
Role of glycopeptide-specific T cells in collagen-induced arthritis: an example how post-translational modification of proteins may be involved in autoimmune disease.
Annals of medicine 2001;33(7):456-65.
2001: A S Hansson; Dick Heinegård; J C Piette; H Burkhardt; Rikard Holmdahl
The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis.
Arthritis and rheumatism 2001;44(10):2402-12.
2001: A S Hansson; Kutty Selva Nandakumar; Johan Bäcklund; Rikard Holmdahl
IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(6):3505-12.
2001: L Jansson; Rikard Holmdahl
Enhancement of collagen-induced arthritis in female mice by estrogen receptor blockage.
Arthritis and rheumatism 2001;44(9):2168-75.
2001: H T Yang; K Bergsteinsdottir; Patrik Wernhoff; C Linington; U Pettersson; Rikard Holmdahl
Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate.
Journal of neuroimmunology 2001;117(1-2):21-9.
2001: M Ehinger; Mikael Vestberg; Ann-Cathrine Johansson; M Johannesson; A Svensson ; Rikard Holmdahl
Influence of CD4 or CD8 deficiency on collagen-induced arthritis.
Immunology 2001;103(3):291-300.
2001: Ann-Cathrine Johansson; Martin Sundler; P Kjellén; Martina Johannesson; A Cook; Anna-Karin B Lindqvist; Britt Nakken; Anne Isine Bolstad; Roland Jonsson; Marta E Alarcón-Riquelme; Rikard Holmdahl
Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcgammaRIIb and is not associated with loci controlling diabetes.
European journal of immunology 2001;31(6):1847-56.
2001: Hans G Kraetsch; C Unger; P Wernhoff; C Schneider; Joachim R Kalden; Rikard Holmdahl; Harald Burkhardt
Cartilage-specific autoimmunity in rheumatoid arthritis: characterization of a triple helical B cell epitope in the integrin-binding-domain of collagen type II.
European journal of immunology 2001;31(6):1666-73.
2001: Rikard Holmdahl; Robert Bockermann; J Jirholt; A Johansson; P Olofsson; Shemin Lu
Elucidation of pathways leading to rheumatoid arthritis by genetic analysis of animal models.
Current directions in autoimmunity 2001;3():17-35.
2001: J Jirholt; A B Lindqvist; Rikard Holmdahl
The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes.
Arthritis research 2001;3(2):87-97.
2000: M Arvola; Erika Elisabet Gustafsson; L Svensson; L Jansson; Rikard Holmdahl; Birgitta Heyman; M Okabe; Ragnar Mattsson
Immunoglobulin-secreting cells of maternal origin can be detected in B cell-deficient mice.
Biology of reproduction 2000;63(6):1817-24.
2000: Niklas Nordquist; Peter Olofsson; Carina Vingsbo-Lundberg; U Petterson; Rikard Holmdahl
Complex genetic control in a rat model for rheumatoid arthritis.
Journal of autoimmunity 2000;15(4):425-32.
2000: E Wellner; Tomas Gustafsson; Johan Bäcklund; Rikard Holmdahl; Jan Kihlberg
Synthesis of a C-glycoside analogue of beta-D-galactosyl hydroxynorvaline and its use in immunological studies.
Chembiochem : a European journal of chemical biology 2000;1(4):272-80.
2000: Khairul-Bariah Abdul-Majid; J Jirholt; Christine Stadelmann; Andreas Stefferl; P Kjellén; Erik Wallström; Rikard Holmdahl; Hans Lassmann; Tomas Olsson; Robert A Harris
Screening of several H-2 congenic mouse strains identified H-2(q) mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement.
Journal of neuroimmunology 2000;111(1-2):23-33.
2000: Ann-Cathrine Johansson; Mikael Vestberg; Rikard Holmdahl
Non-major histocompatibility complex dependent variations in lymphocyte activity between inbred mouse strains susceptible to various autoimmune diseases.
Scandinavian journal of immunology 2000;52(1):21-9.
2000: Inger Gjertsson; Olof H Hultgren; M Stenson; Rikard Holmdahl; Andrej Tarkowski
Are B lymphocytes of importance in severe Staphylococcus aureus infections?
Infection and immunity 2000;68(5):2431-4.
2000: A Corthay; A S Hansson; Rikard Holmdahl
T lymphocytes are not required for the spontaneous development of entheseal ossification leading to marginal ankylosis in the DBA/1 mouse.
Arthritis and rheumatism 2000;43(4):844-51.
2000: K Bergsteinsdottir; H T Yang; Ulf Pettersson; Rikard Holmdahl
Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1564-8.
2000: Rikard Holmdahl
Association of MHC and rheumatoid arthritis. Why is rheumatoid arthritis associated with the MHC genetic region? An introduction.
Arthritis research 2000;2(3):203-4.
2000: Rikard Holmdahl
Rheumatoid arthritis viewed using a headache paradigm.
Arthritis research 2000;2(3):169-71.
2000: V Malmström; Johan Bäcklund; L Jansson; J Kihlberg; Rikard Holmdahl
T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis.
Arthritis research 2000;2(4):315-26.
1999: A S Hansson; Dick Heinegård; Rikard Holmdahl
A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1).
The Journal of clinical investigation 1999;104(5):589-98.
1999: H T Yang; J Jirholt; L Svensson; M Sundvall; L Jansson; Ulf Pettersson; Rikard Holmdahl
Identification of genes controlling collagen-induced arthritis in mice: striking homology with susceptibility loci previously identified in the rat.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2916-21.
1999: Andrej Tarkowski; Jia-Bin Sun; Rikard Holmdahl; Jan Holmgren; Cecil Czerkinsky
Treatment of experimental autoimmune arthritis by nasal administration of a type II collagen-cholera toxoid conjugate vaccine.
Arthritis and rheumatism 1999;42(8):1628-34.
1999: A Corthay; A Johansson; Mikael Vestberg; Rikard Holmdahl
Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice.
International immunology 1999;11(7):1065-73.
1999: Rikard Holmdahl; E C Andersson; C B Andersen; A Svejgaard; Lars Fugger
Transgenic mouse models of rheumatoid arthritis.
Immunological reviews 1999;169():161-73.
1999: Shemin Lu; Rikard Holmdahl
Different therapeutic and bystander effects by intranasal administration of homologous type II and type IX collagens on the collagen-induced arthritis and pristane-induced arthritis in rats.
Clinical immunology (Orlando, Fla.) 1999;90(1):119-27.
1998: S Carlsén; A S Hansson; H Olsson; D Heinegård; Rikard Holmdahl
Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats.
Clinical and experimental immunology 1998;114(3):477-84.
1998: Carina Vingsbo-Lundberg; Niklas Nordquist; Peter Olofsson; M Sundvall; T Saxne; U Pettersson; Rikard Holmdahl
Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats.
Nature genetics 1998;20(4):401-4.
1998: J Jirholt; A Cook; T Emahazion; M Sundvall; L Jansson; Niklas Nordquist; U Pettersson; Rikard Holmdahl
Genetic linkage analysis of collagen-induced arthritis in the mouse.
European journal of immunology 1998;28(10):3321-8.
1998: Mikael Vestberg; U Brunsberg; K Bergsteinsdottir; M Karlsson; Kenth Gustafsson; Dirk Wedekind; Hans J Hedrich; Rikard Holmdahl
Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule.
Immunogenetics 1998;48(5):344-9.
1998: A Corthay; Johan Bäcklund; J Broddefalk; Erik Michaëlsson; T J Goldschmidt; Jan Kihlberg; Rikard Holmdahl
Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis.
European journal of immunology 1998;28(8):2580-90.
1998: L Jansson; Rikard Holmdahl
Estrogen-mediated immunosuppression in autoimmune diseases.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 1998;47(7):290-301.
1998: YX Zhao; U Brunsberg; Rikard Holmdahl; Andrej Tarkowski
V beta 11+ T-lymphocyte expansion by toxic shock syndrome toxin-1 differs in mice bearing H-2q versus H-2b haplotypes.
Immunology 1998;94(1):1-4.
1998: P Kjellén; S Issazadeh; Tomas Olsson; Rikard Holmdahl
Genetic influence on disease course and cytokine response in relapsing experimental allergic encephalomyelitis.
International immunology 1998;10(3):333-40.
1998: L Svensson; J Jirholt; Rikard Holmdahl; L Jansson
B cell-deficient mice do not develop type II collagen-induced arthritis (CIA).
Clinical and experimental immunology 1998;111(3):521-6.
1998: Carina Vingsbo-Lundberg; T Saxne; H Olsson; Rikard Holmdahl
Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats.
Arthritis and rheumatism 1998;41(3):544-50.
1998: Peter Kjellén; U Brunsberg; J Broddefalk; B Hansen; Mikael Vestberg; I Ivarsson; A Engström; A Svejgaard; Jan Kihlberg; Lars Fugger; Rikard Holmdahl
The structural basis of MHC control of collagen-induced arthritis; binding of the immunodominant type II collagen 256-270 glycopeptide to H-2Aq and H-2Ap molecules.
European journal of immunology 1998;28(2):755-67.
1998: S Schulte; C Unger; J A Mo; Olaf Wendler; E Bauer; S Frischholz; Klaus von der Mark; Joachim R Kalden; Rikard Holmdahl; Harald Burkhardt
Arthritis-related B cell epitopes in collagen II are conformation-dependent and sterically privileged in accessible sites of cartilage collagen fibrils.
The Journal of biological chemistry 1998;273(3):1551-61.
1997: YX Zhao; Rikard Holmdahl; Andrej Tarkowski
Induction of selective anergy by toxic shock syndrome toxin-1 in CD8+ T cells.
Immunology 1997;92(2):188-93.
1997: Kathrine Skarstein; Anne Christine Johannessen; Rikard Holmdahl; Roland Jonsson
Effects of sialadenitis after cellular transfer in autoimmune MRL/lpr mice.
Clinical immunology and immunopathology 1997;84(2):177-84.
1997: S Issazadeh; P Kjellén; Tomas Olsson; M Mustafa; Rikard Holmdahl
Major histocompatibility complex-controlled protective influences on experimental autoimmune encephalomyelitis are peptide specific.
European journal of immunology 1997;27(6):1584-7.
1997: V Malmström; K K Ho; J Lun; P P Tam; K S Cheah; Rikard Holmdahl
Arthritis susceptibility in mice expressing human type II collagen in cartilage.
Scandinavian journal of immunology 1997;45(6):670-7.
1997: A Mikulowska; C N Metz; R Bucala; Rikard Holmdahl
Macrophage migration inhibitory factor is involved in the pathogenesis of collagen type II-induced arthritis in mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(11):5514-7.
1997: Dirk Wedekind; CM Prokop; U Brunsberg; Rikard Holmdahl; Hans J Hedrich
Identification and differentiation of transcribed major histocompatibility complex class II RT1B alpha and RT1B beta alleles from laboratory rats.
Transplantation proceedings 1997;29(3):1668-9.
1997: Rikard Holmdahl; Erik Michaëlsson; Mikael Vestberg
B cell presentation of cartilage type II collagen to T cells.
Annals of the New York Academy of Sciences 1997;815():350-2.
1997: A Abdelnour; YX Zhao; Rikard Holmdahl; Andrej Tarkowski
Major histocompatibility complex class II region confers susceptibility to Staphylococcus aureus arthritis.
Scandinavian journal of immunology 1997;45(3):301-7.
1996: S Persson; A Mikulowska; S Narula; A O'Garra; Rikard Holmdahl
Interleukin-10 suppresses the development of collagen type II-induced arthritis and ameliorates sustained arthritis in rats.
Scandinavian journal of immunology 1996;44(6):607-14.
1996: C Vingsbo; P Sahlstrand; J G Brun; R Jonsson; T Saxne; Rikard Holmdahl
Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes.
The American journal of pathology 1996;149(5):1675-83.
1996: J A Mo; Rikard Holmdahl
The B cell response to autologous type II collagen: biased V gene repertoire with V gene sharing and epitope shift.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2440-8.
1996: Erik Michaëlsson; J Broddefalk; A Engström; Jan Kihlberg; Rikard Holmdahl
Antigen processing and presentation of a naturally glycosylated protein elicits major histocompatibility complex class II-restricted, carbohydrate-specific T cells.
European journal of immunology 1996;26(8):1906-10.
1996: Erika Elisabet Gustafsson; G Blomqvist; A Bellman; Rikard Holmdahl; A Mattsson; Ragnar Mattsson
Maternal antibodies protect immunoglobulin deficient neonatal mice from mouse hepatitis virus (MHV)-associated wasting syndrome.
American journal of reproductive immunology (New York, N.Y. : 1989) 1996;36(1):33-9.
1996: V Malmström; Erik Michaëlsson; H Burkhardt; Ragnar Mattsson; E Vuorio; Rikard Holmdahl
Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4480-5.
1996: A Abdelnour; YX Zhao; Tomas Bremell; Rikard Holmdahl; Andrej Tarkowski
Role of superantigens in experimental arthritis.
Springer seminars in immunopathology 1996;17(4):363-73.
1995: Margareta Verdrengh; Rikard Holmdahl; Andrej Tarkowski
Administration of antibodies to hyaluronanreceptor (CD44) delays the start and ameliorates the severity of collagen II arthritis.
Scandinavian journal of immunology 1995;42(3):353-8.
1995: YX Zhao; A Abdelnour; Rikard Holmdahl; Andrej Tarkowski
Mice with the xid B cell defect are less susceptible to developing Staphylococcus aureus-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):2067-76.
1995: Erik Michaëlsson; M Holmdahl; A Engström; H Burkhardt; A Scheynius; Rikard Holmdahl
Macrophages, but not dendritic cells, present collagen to T cells.
European journal of immunology 1995;25(8):2234-41.
1995: L Jansson; P Diener; A Engström; T Olsson; Rikard Holmdahl
Spreading of the immune response to different myelin basic protein peptides in chronic experimental autoimmune encephalomyelitis in B10.RIII mice.
European journal of immunology 1995;25(8):2195-200.
1995: Rikard Holmdahl
Female preponderance for development of arthritis in rats is influenced by both sex chromosomes and sex steroids.
Scandinavian journal of immunology 1995;42(1):104-9.
1995: M Sundvall; J Jirholt; H T Yang; L Jansson; A Engström; Ulf Pettersson; Rikard Holmdahl
Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis.
Nature genetics 1995;10(3):313-7.
1995: Rikard Holmdahl; C Vingsbo; J A Mo; Erik Michaëlsson; V Malmström; L Jansson; U Brunsberg
Chronicity of tissue-specific experimental autoimmune disease: a role for B cells?
Immunological reviews 1995;144():109-35.
1995: C Vingsbo; R Jonsson; Rikard Holmdahl
Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes.
Clinical and experimental immunology 1995;99(3):359-63.
1994: Erika Elisabet Gustafsson; A Mattsson; Rikard Holmdahl; Ragnar Mattsson
Pregnancy in B-cell-deficient mice: postpartum transfer of immunoglobulins prevents neonatal runting and death.
Biology of reproduction 1994;51(6):1173-80.
1994: Rikard Holmdahl; C Vingsbo; V Malmström; L Jansson; M Holmdahl
Chronicity of arthritis induced with homologous type II collagen (CII) in rats is associated with anti-CII B-cell activation.
Journal of autoimmunity 1994;7(6):739-52.
1994: Tomas Bremell; Rikard Holmdahl; Andrej Tarkowski
Protective role of sialophorin (CD43)-expressing cells in experimental Staphylococcus aureus infection.
Infection and immunity 1994;62(10):4637-40.
1994: M Mustafa; C Vingsbo; Tomas Olsson; S Issazadeh; A Ljungdahl; Rikard Holmdahl
Protective influences on experimental autoimmune encephalomyelitis by MHC class I and class II alleles.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):3337-44.
1994: L Jansson; T Olsson; Rikard Holmdahl
Estrogen induces a potent suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis in mice.
Journal of neuroimmunology 1994;53(2):203-7.
1994: Erik Michaëlsson; V Malmström; S Reis; A Engström; H Burkhardt; Rikard Holmdahl
T cell recognition of carbohydrates on type II collagen.
The Journal of experimental medicine 1994;180(2):745-9.
1994: U Brunsberg; K Gustafsson; L Jansson; Erik Michaëlsson; Lars Ahrlund-Richter; S Pettersson; Ragnar Mattsson; Rikard Holmdahl
Expression of a transgenic class II Ab gene confers susceptibility to collagen-induced arthritis.
European journal of immunology 1994;24(7):1698-702.
1994: Tomas Bremell; S Lange; Rikard Holmdahl; Cecilia Rydén; G K Hansson; Andrej Tarkowski
Immunopathological features of rat Staphylococcus aureus arthritis.
Infection and immunity 1994;62(6):2334-44.
1994: L Jansson; Rikard Holmdahl
The Y chromosome-linked "autoimmune accelerating" yaa gene suppresses collagen-induced arthritis.
European journal of immunology 1994;24(5):1213-7.
1994: A Abdelnour; Tomas Bremell; Rikard Holmdahl; Andrej Tarkowski
Clonal expansion of T lymphocytes causes arthritis and mortality in mice infected with toxic shock syndrome toxin-1-producing staphylococci.
European journal of immunology 1994;24(5):1161-6.
1994: A Abdelnour; Tomas Bremell; Rikard Holmdahl; Andrej Tarkowski
Role of T lymphocytes in experimental Staphylococcus aureus arthritis.
Scandinavian journal of immunology 1994;39(4):403-8.
1994: T J Goldschmidt; Rikard Holmdahl
Therapeutic effects of monoclonal antibodies to alpha beta TCR but not to CD4 on collagen-induced arthritis in the rat.
Cellular immunology 1994;154(1):240-8.
1994: J A Mo; A Scheynius; S Nilsson; Rikard Holmdahl
Germline-encoded IgG antibodies bind mouse cartilage in vivo: epitope- and idiotype-specific binding and inhibition.
Scandinavian journal of immunology 1994;39(2):122-30.
1993: L Jansson; Rikard Holmdahl
Genes on the X chromosome affect development of collagen-induced arthritis in mice.
Clinical and experimental immunology 1993;94(3):459-65.
1993: M Mustafa; C Vingsbo; Tomas Olsson; A Ljungdahl; B Höjeberg; Rikard Holmdahl
The major histocompatibility complex influences myelin basic protein 63-88-induced T cell cytokine profile and experimental autoimmune encephalomyelitis.
European journal of immunology 1993;23(12):3089-95.
1993: Rikard Holmdahl; M Karlsson
Rapid method to determine structural polymorphism of rat major histocompatibility complex class II genes.
Transplantation proceedings 1993;25(5):2770.
1993: J A Mo; C A Bona; Rikard Holmdahl
Variable region gene selection of immunoglobulin G-expressing B cells with specificity for a defined epitope on type II collagen.
European journal of immunology 1993;23(10):2503-10.
1993: I Hansson; Rikard Holmdahl; Ragnar Mattsson
Pinealectomy ameliorates collagen II-induced arthritis in mice.
Clinical and experimental immunology 1993;92(3):432-6.
1993: Rikard Holmdahl; V Malmström; E Vuorio
Autoimmune recognition of cartilage collagens.
Annals of medicine 1993;25(3):251-64.
1993: C Vingsbo; P Larsson; M Andersson; Rikard Holmdahl
Association of pepsin with type II collagen (CII) breaks control of CII autoimmunity and triggers development of arthritis in rats.
Scandinavian journal of immunology 1993;37(3):337-42.
1993: Rikard Holmdahl; M Karlsson; K Gustafsson; H Hedrich
Structural polymorphism of six rat RT1Ba genes.
Immunogenetics 1993;38(5):381.
1993: L Jansson; T Olsson; Rikard Holmdahl
Influence of T-cell receptor genes on chronic experimental autoimmune encephalomyelitis.
Immunogenetics 1993;37(6):466-8.
1992: L Jansson; Rikard Holmdahl
Oestrogen-induced suppression of collagen arthritis; 17 beta-oestradiol is therapeutically active in normal and castrated F1 hybrid mice of both sexes.
Clinical and experimental immunology 1992;89(3):446-51.
1992: I Hansson; Rikard Holmdahl; Ragnar Mattsson
The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice.
Journal of neuroimmunology 1992;39(1-2):23-30.
1992: Erik Michaëlsson; M Andersson; A Engström; Rikard Holmdahl
Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice: self tolerance at the level of determinant selection.
European journal of immunology 1992;22(7):1819-25.
1992: Rikard Holmdahl; T J Goldschmidt; Sandra Kleinau; C Kvick; R Jonsson
Arthritis induced in rats with adjuvant oil is a genetically restricted, alpha beta T-cell dependent autoimmune disease.
Immunology 1992;76(2):197-202.
1992: Rikard Holmdahl; L Jansson; M Andersson; R Jonsson
Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice.
Clinical and experimental immunology 1992;88(3):467-72.
1992: Ragnar Mattsson; A Mattsson; Rikard Holmdahl; A Scheynius; P H Van der Meide
In vivo treatment with interferon-gamma during early pregnancy in mice induces strong expression of major histocompatibility complex class I and II molecules in uterus and decidua but not in extra-embryonic tissues.
Biology of reproduction 1992;46(6):1176-86.
1992: C Nordling; A Karlsson-Parra; L Jansson; Rikard Holmdahl; Lars Klareskog
Characterization of a spontaneously occurring arthritis in male DBA/1 mice.
Arthritis and rheumatism 1992;35(6):717-22.
1992: S Persson; C Post; Rikard Holmdahl; Fred Nyberg
Decreased neuropeptide-converting enzyme activities in cerebrospinal fluid during acute but not chronic phases of collagen induced arthritis in rats.
Brain research 1992;581(2):273-82.
1992: Rikard Holmdahl; C Kvick
Vaccination and genetic experiments demonstrate that adjuvant-oil-induced arthritis and homologous type II collagen-induced arthritis in the same rat strain are different diseases.
Clinical and experimental immunology 1992;88(1):96-100.
1992: T J Goldschmidt; M Andersson; V Malmström; Rikard Holmdahl
Activated type II collagen reactive T cells are not eliminated by in vivo anti-CD4 treatment. Implications for therapeutic approaches on autoimmune arthritis.
Immunobiology 1992;184(4-5):359-71.
1992: JL Cabero; T Sasaki; Y H Song; Rikard Holmdahl; Sven Mårdh
Production of monoclonal antibodies against gastric parietal cell antigens.
Acta physiologica Scandinavica 1992;144(3):369-78.
1992: Rikard Holmdahl; C Vingsbo; H Hedrich; M Karlsson; C Kvick; T J Goldschmidt; K Gustafsson
Homologous collagen-induced arthritis in rats and mice are associated with structurally different major histocompatibility complex DQ-like molecules.
European journal of immunology 1992;22(2):419-24.
1992: Ragnar Mattsson; A Mattsson; I Hansson; Rikard Holmdahl; Graham Rook; A Whyte
Increased levels of prolactin during, but not after, the immunisation with rat collagen II enhances the course of arthritis in DBA/1 mice.
Autoimmunity 1992;11(3):163-70.
1991: Sandra Kleinau; H Erlandsson; Rikard Holmdahl; Lars Klareskog
Adjuvant oils induce arthritis in the DA rat. I. Characterization of the disease and evidence for an immunological involvement.
Journal of autoimmunity 1991;4(6):871-80.
1991: E Hörnqvist; T J Goldschmidt; Rikard Holmdahl; Nils Lycke
Host defense against cholera toxin is strongly CD4+ T cell dependent.
Infection and immunity 1991;59(10):3630-8.
1991: Ragnar Mattsson; A Mattsson; Rikard Holmdahl; A Whyte; Graham Rook
Maintained pregnancy levels of oestrogen afford complete protection from post-partum exacerbation of collagen-induced arthritis.
Clinical and experimental immunology 1991;85(1):41-7.
1991: C Nordling; Rikard Holmdahl; Lars Klareskog
A monoclonal antiidiotypic antibody with rheumatoid factor activity defines a cross-reactive idiotope on murine anticollagen antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(12):4258-63.
1991: M Andersson; T J Goldschmidt; Erik Michaëlsson; A Larsson; Rikard Holmdahl
T-cell receptor V beta haplotype and complement component C5 play no significant role for the resistance to collagen-induced arthritis in the SWR mouse.
Immunology 1991;73(2):191-6.
1991: Hans Carlsten; Rikard Holmdahl; Andrej Tarkowski
Analysis of the genetic encoding of oestradiol suppression of delayed-type hypersensitivity in (NZB x NZW) F1 mice.
Immunology 1991;73(2):186-90.
1991: T J Goldschmidt; Rikard Holmdahl
Anti-T cell receptor antibody treatment of rats with established autologous collagen-induced arthritis: suppression of arthritis without reduction of anti-type II collagen autoantibody levels.
European journal of immunology 1991;21(5):1327-30.
1991: M Andersson; M A Cremer; K Terato; H Burkhardt; Rikard Holmdahl
Analysis of type II collagen reactive T cells in the mouse. II. Different localization of immunodominant T cell epitopes on heterologous and autologous type II collagen.
Scandinavian journal of immunology 1991;33(5):505-10.
1991: C Nordling; Rikard Holmdahl; Lars Klareskog
Down-regulation of collagen arthritis after in vivo treatment with a syngeneic monoclonal anti-idiotypic antibody to a cross-reactive idiotope on collagen II auto-antibodies.
Immunology 1991;72(4):486-90.
1991: L Jansson; T Olsson; B Höjeberg; Rikard Holmdahl
Chronic experimental autoimmune encephalomyelitis induced by the 89-101 myelin basic protein peptide in B10RIII (H-2r) mice.
European journal of immunology 1991;21(3):693-9.
1991: Ragnar Mattsson; Rikard Holmdahl; A Scheynius; F Bernadotte; A Mattsson; P H Van der Meide
Placental MHC class I antigen expression is induced in mice following in vivo treatment with recombinant interferon-gamma.
Journal of reproductive immunology 1991;19(2):115-29.
1991: Rikard Holmdahl; J A Mo; R Jonsson; K Karlstrom; A Scheynius
Multiple epitopes on cartilage type II collagen are accessible for antibody binding in vivo.
Autoimmunity 1991;10(1):27-34.
1991: Rikard Holmdahl; A Tarkowski; R Jonsson
Involvement of macrophages and dendritic cells in synovial inflammation of collagen induced arthritis in DBA/1 mice and spontaneous arthritis in MRL/lpr mice.
Autoimmunity 1991;8(4):271-80.
1990: Rikard Holmdahl; M Andersson; T J Goldschmidt; K Gustafsson; L Jansson; J A Mo
Type II collagen autoimmunity in animals and provocations leading to arthritis.
Immunological reviews 1990;118():193-232.
1990: Andrej Tarkowski; B Kjellson; Hans Carlsten; Rikard Holmdahl; E Josefsson; C Trollmo
Frequency and phenotypic feature of autoantibody-producing cell precursors in the preclinical stage of murine lupus.
Immunology 1990;71(3):335-40.
1990: L Jansson; A Mattsson; Ragnar Mattsson; Rikard Holmdahl
Estrogen induced suppression of collagen arthritis. V: Physiological level of estrogen in DBA/1 mice is therapeutic on established arthritis, suppresses anti-type II collagen T-cell dependent immunity and stimulates polyclonal B-cell activity.
Journal of autoimmunity 1990;3(3):257-70.
1990: A Larsson; Rikard Holmdahl
A microELISA useful for determination of protein A-binding monoclonal antibodies.
Hybridoma 1990;9(3):289-94.
1990: P Larsson; Sandra Kleinau; Rikard Holmdahl; Lars Klareskog
Homologous type II collagen-induced arthritis in rats. Characterization of the disease and demonstration of clinically distinct forms of arthritis in two strains of rats after immunization with the same collagen preparation.
Arthritis and rheumatism 1990;33(5):693-701.
1990: K Strigård; Rikard Holmdahl; Tomas Olsson
Oestrogen treatment reduces duration of experimental allergic neuritis in rats and suppresses T cell responses to myelin.
Acta neurologica Scandinavica 1990;81(5):436-42.
1990: M Andersson; Rikard Holmdahl
Analysis of type II collagen-reactive T cells in the mouse. I. Different regulation of autoreactive vs. non-autoreactive anti-type II collagen T cells in the DBA/1 mouse.
European journal of immunology 1990;20(5):1061-6.
1990: I Hansson; Rikard Holmdahl; Ragnar Mattsson
Constant darkness enhances autoimmunity to type II collagen and exaggerates development of collagen-induced arthritis in DBA/1 mice.
Journal of neuroimmunology 1990;27(1):79-84.
1990: T J Goldschmidt; L Jansson; Rikard Holmdahl
In vivo elimination of T cells expressing specific T-cell receptor V beta chains in mice susceptible to collagen-induced arthritis.
Immunology 1990;69(4):508-14.
1990: Rikard Holmdahl; L Jansson; A Larsson; R Jonsson
Arthritis in DBA/1 mice induced with passively transferred type II collagen immune serum. Immunohistopathology and serum levels of anti-type II collagen auto-antibodies.
Scandinavian journal of immunology 1990;31(2):147-57.
1989: P Larsson; T J Goldschmidt; Lars Klareskog; Rikard Holmdahl
Oestrogen-mediated suppression of collagen-induced arthritis in rats. Studies on the role of the thymus and of peripheral CD8+ T lymphocytes.
Scandinavian journal of immunology 1989;30(6):741-7.
1989: Rikard Holmdahl; M Karlsson; M E Andersson; L Rask; Leif Andersson
Localization of a critical restriction site on the I-A beta chain that determines susceptibility to collagen-induced arthritis in mice.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(23):9475-9.
1989: F Bernadotte; Rikard Holmdahl; C Juhlin; Ragnar Mattsson
Expression of a cell surface antigen with potential Ca2+-sensor/receptor function in rat placenta and uterus.
Journal of reproductive immunology 1989;16(2):199-205.
1989: Hans Carlsten; Rikard Holmdahl; Andrej Tarkowski; LA Nilsson
Oestradiol- and testosterone-mediated effects on the immune system in normal and autoimmune mice are genetically linked and inherited as dominant traits.
Immunology 1989;68(2):209-14.
1989: Sandra Kleinau; P Larsson; J Björk; Rikard Holmdahl; Lars Klareskog
Linomide, a new immunomodulatory drug, shows different effects on homologous versus heterologous collagen-induced arthritis in rats.
Clinical and experimental immunology 1989;78(1):138-42.
1989: Rikard Holmdahl
Estrogen exaggerates lupus but suppresses T-cell-dependent autoimmune disease.
Journal of autoimmunity 1989;2(5):651-6.
1989: Rikard Holmdahl; J Mo; C Nordling; P Larsson; L Jansson; T Goldschmidt; M Andersson; Lars Klareskog
Collagen induced arthritis: an experimental model for rheumatoid arthritis with involvement of both DTH and immune complex mediated mechanisms.
Clinical and experimental rheumatology 1989;7 Suppl 3():S51-5.
1989: K Strigård; Rikard Holmdahl; Peter van der Meide; L Klareskog; Tomas Olsson
In vivo treatment of rats with monoclonal antibodies against gamma interferon: effects on experimental allergic neuritis.
Acta neurologica Scandinavica 1989;80(3):201-7.
1989: Rikard Holmdahl; M E Andersson; T J Goldschmidt; L Jansson; M Karlsson; V Malmström; J Mo
Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogenetics, pathogenesis and autoimmunity.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1989;97(7):575-84.
1989: Hans Carlsten; Rikard Holmdahl; Andrej Tarkowski; LA Nilsson
Oestradiol suppression of delayed-type hypersensitivity in autoimmune (NZB/NZW)F1 mice is a trait inherited from the healthy NZW parental strain.
Immunology 1989;67(2):205-9.
1989: K Strigård; P Larsson; Rikard Holmdahl; L Klareskog; Tomas Olsson
In vivo monoclonal antibody treatment with Ox19 (anti-rat CD5) causes disease relapse and terminates P2-induced immunospecific tolerance in experimental allergic neuritis.
Journal of neuroimmunology 1989;23(1):11-8.
1989: L Jansson; Rikard Holmdahl
Oestrogen induced suppression of collagen arthritis. IV: Progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect.
Journal of reproductive immunology 1989;15(2):141-50.
1989: P Larsson; Rikard Holmdahl; Lars Klareskog
In vivo treatment with anti-CD8 and anti-CD5 monoclonal antibodies alters induced tolerance to adjuvant arthritis.
Journal of cellular biochemistry 1989;40(1):49-56.
1989: Rikard Holmdahl; C Bailey; I Enander; R Mayer; Lars Klareskog; T Moran; C Bona
Origin of the autoreactive anti-type II collagen response. II. Specificities, antibody isotypes and usage of V gene families of anti-type II collagen B cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(6):1881-6.
1989: Rikard Holmdahl; H Carlsten; L Jansson; P Larsson
Oestrogen is a potent immunomodulator of murine experimental rheumatoid disease.
British journal of rheumatology 1989;28 Suppl 1():54-8; discussion 69-71.
1988: P Sulila; Rikard Holmdahl; I Hansson; F Bernadotte; A Mattsson; Ragnar Mattsson
An investigation of allogeneic pregnancy in multiparous mice subjected to in vivo depletion of CD8 (Ly2)-positive lymphocytes by monoclonal antibody treatment.
Journal of reproductive immunology 1988;14(3):235-45.
1988: Rikard Holmdahl; L Jansson; M Andersson; E Larsson
Immunogenetics of type II collagen autoimmunity and susceptibility to collagen arthritis.
Immunology 1988;65(2):305-10.
1988: N J Mauritz; Rikard Holmdahl; R Jonsson; P H Van der Meide; A Scheynius; Lars Klareskog
Treatment with gamma-interferon triggers the onset of collagen arthritis in mice.
Arthritis and rheumatism 1988;31(10):1297-304.
1988: Rikard Holmdahl; M Andersson; I Enander; T Goldschmidt; L Jansson; P Larsson; J Mo; C Nordling; Lars Klareskog
Nature of the type II collagen autoimmunity in mice susceptible to collagen-induced arthritis.
International reviews of immunology 1988;4(1):49-64.
1988: K Strigård; Tomas Olsson; P Larsson; Rikard Holmdahl; B Höjeberg; L Klareskog
Elimination of CD8+ T cells in vivo does not break induced immunospecific tolerance to experimental allergic neuritis in rats.
Scandinavian journal of immunology 1988;28(3):325-30.
1988: T J Goldschmidt; Rikard Holmdahl; Lars Klareskog
Depletion of murine T cells by in vivo monoclonal antibody treatment is enhanced by adding an autologous anti-rat kappa chain antibody.
Journal of immunological methods 1988;111(2):219-26.
1988: Rikard Holmdahl; L Jansson
Estrogen-induced suppression of collagen arthritis. III. Adult thymectomy does not affect the course of arthritis or the estrogen-mediated suppression of T-cell immunity.
Brain, behavior, and immunity 1988;2(2):123-32.
1988: C Skoglund; A Scheynius; Rikard Holmdahl; P H Van der Meide
Enhancement of DTH reaction and inhibition of the expression of class II transplantation antigens by in vivo treatment with antibodies against gamma-interferon.
Clinical and experimental immunology 1988;71(3):428-32.
1988: K Strigård; Tomas Olsson; P Larsson; Rikard Holmdahl; L Klareskog
Modulation of experimental allergic neuritis in rats by in vivo treatment with monoclonal anti T cell antibodies.
Journal of the neurological sciences 1988;83(2-3):283-91.
1988: Tomas Olsson; K Strigård; P Larsson; Rikard Holmdahl; L Klareskog
Effects on experimental allergic neuritis in rats by in vivo treatment with monoclonal anti-T-cell antibodies.
Annals of the New York Academy of Sciences 1988;540():560-2.
1988: Rikard Holmdahl; R Jonsson; P Larsson; Lars Klareskog
Early appearance of activated CD4+ T lymphocytes and class II antigen-expressing cells in joints of DBA/1 mice immunized with type II collagen.
Laboratory investigation; a journal of technical methods and pathology 1988;58(1):53-60.
1988: A Scheynius; C Skoglund; Catharina Johansson; Rikard Holmdahl; P H van der Meide
The rat as an experimental model for studies on immune regulating mechanisms in contact allergic reactions.
Acta dermato-venereologica. Supplementum 1988;135():54-6.
1987: Rikard Holmdahl; L Jansson; B Meyerson; Lars Klareskog
Oestrogen induced suppression of collagen arthritis: I. Long term oestradiol treatment of DBA/1 mice reduces severity and incidence of arthritis and decreases the anti type II collagen immune response.
Clinical and experimental immunology 1987;70(2):372-8.
1987: P Larsson; Rikard Holmdahl
Oestrogen-induced suppression of collagen arthritis. II. Treatment of rats suppresses development of arthritis but does not affect the anti-type II collagen humoral response.
Scandinavian journal of immunology 1987;26(5):579-83.
1987: Ragnar Mattsson; Rikard Holmdahl
Maintained allogeneic pregnancy in rats depleted of T cytotoxic/suppressor cells by OX8 monoclonal antibody treatment.
Journal of reproductive immunology 1987;12(1):23-34.
1987: Rikard Holmdahl; A Tarkowski; C Nordling; Kristofer Rubin; Lars Klareskog
Connection between autoimmunity to cartilage type II collagen and rheumatoid factor production.
Monographs in allergy 1987;22():71-80.
1987: Lars Klareskog; Rikard Holmdahl; T Goldschmidt; J Björk
Immunoregulation in arthritis. A review on synovial immune reactions in RA and in some experimental animal models for arthritis.
Scandinavian journal of rheumatology. Supplement 1987;64():7-15.
1987: Lars Klareskog; Rikard Holmdahl; C Nordling; A Tarkowski; Kristofer Rubin
Synovial class II antigen expression and immune complex formation in rheumatoid arthritis.
Acta medica Scandinavica. Supplementum 1987;715():85-91.
1986: Rikard Holmdahl; Lars Klareskog; K Rubin; J Björk; G Smedegård; R Jonsson; M Andersson
Role of T lymphocytes in murine collagen induced arthritis.
Agents and actions 1986;19(5-6):295-305.
1986: Rikard Holmdahl; C Nordling; Kristofer Rubin; A Tarkowski; Lars Klareskog
Generation of monoclonal rheumatoid factors after immunization with collagen II-anti-collagen II immune complexes. An anti-idiotypic antibody to anti-collagen II is also a rheumatoid factor.
Scandinavian journal of immunology 1986;24(2):197-203.