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Elaine Holmes

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Coen Muireann; Want Elizabeth J; Clayton T Andrew; Rhode Cynthia M; Hong Young Shick; Keun Hector C; Cantor Glenn H; Metz Alan L; Robertson Donald G; Reily Michael D; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis.
Saric Jasmina; Li Jia V; Wang Yulan; Keiser Jennifer; Veselkov Kirill; Dirnhofer Stephan; Yap Ivan K S; Nicholson Jeremy K; Holmes Elaine; Utzinger Jürg
Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse.
Martin Francois-Pierre J; Wang Yulan; Yap Ivan K S; Sprenger Norbert; Lindon John C; Rezzi Serge; Kochhar Sunil; Holmes Elaine; Nicholson Jeremy K
Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity.

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All Publications

2009: Coen Muireann; Want Elizabeth J; Clayton T Andrew; Rhode Cynthia M; Hong Young Shick; Keun Hector C; Cantor Glenn H; Metz Alan L; Robertson Donald G; Reily Michael D; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis.
Journal of proteome research 2009;8(11):5175-87.
2009: Saric Jasmina; Li Jia V; Wang Yulan; Keiser Jennifer; Veselkov Kirill; Dirnhofer Stephan; Yap Ivan K S; Nicholson Jeremy K; Holmes Elaine; Utzinger Jürg
Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse.
Journal of proteome research 2009;8(8):3899-911.
2009: Martin Francois-Pierre J; Wang Yulan; Yap Ivan K S; Sprenger Norbert; Lindon John C; Rezzi Serge; Kochhar Sunil; Holmes Elaine; Nicholson Jeremy K
Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity.
Journal of proteome research 2009;8(7):3464-74.
2009: Loo Ruey Leng; Coen Muireann; Ebbels Timothy; Cloarec Olivier; Maibaum Elaine; Bictash Magda; Yap Ivan; Elliott Paul; Stamler Jeremiah; Nicholson Jeremy K; Holmes Elaine;
Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies.
Analytical chemistry 2009;81(13):5119-29.
2009: Tsang T M; Haselden J N; Holmes E
Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.
Neurochemical research 2009;34(7):1261-71.
2009: Smith Leon M; Maher Anthony D; Want Elizabeth J; Elliott Paul; Stamler Jeremiah; Hawkes Geoffrey E; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation.
Analytical chemistry 2009;81(12):4847-56.
2009: Waldram Alison; Holmes Elaine; Wang Yulan; Rantalainen Mattias; Wilson Ian D; Tuohy Kieran M; McCartney Anne L; Gibson Glenn R; Nicholson Jeremy K
Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents.
Journal of proteome research 2009;8(5):2361-75.
2009: McLoughlin Gerard A; Ma Dan; Tsang Tsz M; Jones Declan N C; Cilia Jackie; Hill Mark D; Robbins Melanie J; Benzel Isabel M; Maycox Peter R; Holmes Elaine; Bahn Sabine
Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy.
Journal of proteome research 2009;8(4):1943-52.
2009: Swann Jonathan; Wang Yulan; Abecia Leticia; Costabile Adele; Tuohy Kieran; Gibson Glenn; Roberts David; Sidaway James; Jones Huw; Wilson Ian D; Nicholson Jeremy; Holmes Elaine
Gut microbiome modulates the toxicity of hydrazine: a metabonomic study.
Molecular bioSystems 2009;5(4):351-5.
2009: Martin Francois-Pierre J; Sprenger Norbert; Yap Ivan K S; Wang Yulan; Bibiloni Rodrigo; Rochat Florence; Rezzi Serge; Cherbut Christine; Kochhar Sunil; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Panorganismal gut microbiome-host metabolic crosstalk.
Journal of proteome research 2009;8(4):2090-105.
2009: Li Jia V; Holmes Elaine; Saric Jasmina; Keiser Jennifer; Dirnhofer Stephan; Utzinger Jürg; Wang Yulan
Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy.
International journal for parasitology 2009;39(5):547-58.
2009: Duarte Iola F; Legido-Quigley Cristina; Parker David A; Swann Jonathan R; Spraul Manfred; Braumann Ulrich; Gil Ana M; Holmes Elaine; Nicholson Jeremy K; Murphy Gerard M; Vilca-Melendez Hector; Heaton Nigel; Lindon John C
Identification of metabolites in human hepatic bile using 800 MHz 1H NMR spectroscopy, HPLC-NMR/MS and UPLC-MS.
Molecular bioSystems 2009;5(2):180-90.
2009: Maher Anthony D; Cloarec Olivier; Patki Prasad; Craggs Michael; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Dynamic biochemical information recovery in spontaneous human seminal fluid reactions via 1H NMR kinetic statistical total correlation spectroscopy.
Analytical chemistry 2009;81(1):288-95.
2009: Veselkov Kirill A; Lindon John C; Ebbels Timothy M D; Crockford Derek; Volynkin Vladimir V; Holmes Elaine; Davies David B; Nicholson Jeremy K
Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery.
Analytical chemistry 2009;81(1):56-66.
2009: Kinross James; von Roon Alexander C; Penney Nicholas; Holmes Elaine; Silk David; Nicholson Jeremy K; Darzi Ara
The gut microbiota as a target for improved surgical outcome and improved patient care.
Current pharmaceutical design 2009;15(13):1537-45.
2008: Maher Anthony D; Patki Prasad; Lindon John C; Want Elizabeth J; Holmes Elaine; Craggs Michael; Nicholson Jeremy K
Seminal oligouridinosis: low uridine secretion as a biomarker for infertility in spinal neurotrauma.
Clinical chemistry 2008;54(12):2063-6.
2008: Maher Anthony D; Crockford Derek; Toft Henrik; Malmodin Daniel; Faber Johan H; McCarthy Mark I; Barrett Amy; Allen Maxine; Walker Mark; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes.
Analytical chemistry 2008;80(19):7354-62.
2008: Bohus Eszter; Coen Muireann; Keun Hector C; Ebbels Timothy M D; Beckonert Olaf; Lindon John C; Holmes Elaine; Noszál Béla; Nicholson Jeremy K
Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis.
Journal of proteome research 2008;7(10):4435-45.
2008: Holmes Elaine; Wilson Ian D; Nicholson Jeremy K
Metabolic phenotyping in health and disease.
Cell 2008;134(5):714-7.
2008: Yap Ivan K S; Li Jia V; Saric Jasmina; Martin Francois-Pierre; Davies Huw; Wang Yulan; Wilson Ian D; Nicholson Jeremy K; Utzinger Jürg; Marchesi Julian R; Holmes Elaine
Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse.
Journal of proteome research 2008;7(9):3718-28.
2008: Papaspyridonos Konstantina; Garcia-Perez Isabel; Angulo Santiago; Domann Paula J; Vilca-Melendez Hector; Heaton Nigel; Murphy Gerard M; Holmes Elaine; Barbas Coral; Legido-Quigley Cristina
Fingerprinting of human bile during liver transplantation by capillary electrophoresis.
Journal of separation science 2008;31(16-17):3058-64.
2008: Li Jia V; Wang Yulan; Saric Jasmina; Nicholson Jeremy K; Dirnhofer Stephan; Singer Burton H; Tanner Marcel; Wittlin Sergio; Holmes Elaine; Utzinger Jürg
Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection.
Journal of proteome research 2008;7(9):3948-56.
2008: Kinross James M; von Roon Alexander C; Holmes Elaine; Darzi Ara; Nicholson Jeremy K
The human gut microbiome: implications for future health care.
Current gastroenterology reports 2008;10(4):396-403.
2008: Richards Selena E; Wang Yulan; Lawler Dennis; Kochhar Sunil; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Self-modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: application to a life-long caloric restriction study in dogs.
Analytical chemistry 2008;80(13):4876-85.
2008: Holmes Elaine; Loo Ruey Leng; Stamler Jeremiah; Bictash Magda; Yap Ivan K S; Chan Queenie; Ebbels Tim; De Iorio Maria; Brown Ian J; Veselkov Kirill A; Daviglus Martha L; Kesteloot Hugo; Ueshima Hirotsugu; Zhao Liancheng; Nicholson Jeremy K; Elliott Paul
Human metabolic phenotype diversity and its association with diet and blood pressure.
Nature 2008;453(7193):396-400.
2008: Wang Yulan; Utzinger Jürg; Saric Jasmina; Li Jia V; Burckhardt Jean; Dirnhofer Stephan; Nicholson Jeremy K; Singer Burton H; Brun Reto; Holmes Elaine
Global metabolic responses of mice to Trypanosoma brucei brucei infection.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6127-32.
2008: Barton Richard H; Nicholson Jeremy K; Elliott Paul; Holmes Elaine
High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study.
International journal of epidemiology 2008;37 Suppl 1():i31-40.
2008: Li Min; Wang Baohong; Zhang Menghui; Rantalainen Mattias; Wang Shengyue; Zhou Haokui; Zhang Yan; Shen Jian; Pang Xiaoyan; Zhang Meiling; Wei Hua; Chen Yu; Lu Haifeng; Zuo Jian; Su Mingming; Qiu Yunping; Jia Wei; Xiao Chaoni; Smith Leon M; Yang Shengli; Holmes Elaine; Tang Huiru; Zhao Guoping; Nicholson Jeremy K; Li Lanjuan; Zhao Liping
Symbiotic gut microbes modulate human metabolic phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2117-22.
2008: Keun Hector C; Athersuch Toby J; Beckonert Olaf; Wang Yulan; Saric Jasmina; Shockcor John P; Lindon John C; Wilson Ian D; Holmes Elaine; Nicholson Jeremy K
Heteronuclear 19F-1H statistical total correlation spectroscopy as a tool in drug metabolism: study of flucloxacillin biotransformation.
Analytical chemistry 2008;80(4):1073-9.
2008: Wang Yulan; Cloarec Olivier; Tang Huiru; Lindon John C; Holmes Elaine; Kochhar Sunil; Nicholson Jeremy K
Magic angle spinning NMR and 1H-31P heteronuclear statistical total correlation spectroscopy of intact human gut biopsies.
Analytical chemistry 2008;80(4):1058-66.
2008: Bang Jung-Wook; Crockford Derek J; Holmes Elaine; Pazos Florencio; Sternberg Michael J E; Muggleton Stephen H; Nicholson Jeremy K
Integrative top-down system metabolic modeling in experimental disease states via data-driven Bayesian methods.
Journal of proteome research 2008;7(2):497-503.
2008: Coen Muireann; Holmes Elaine; Lindon John C; Nicholson Jeremy K
NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology.
Chemical research in toxicology 2008;21(1):9-27.
2008: Saric Jasmina; Wang Yulan; Li Jia; Coen Muireann; Utzinger Jürg; Marchesi Julian R; Keiser Jennifer; Veselkov Kirill; Lindon John C; Nicholson Jeremy K; Holmes Elaine
Species variation in the fecal metabolome gives insight into differential gastrointestinal function.
Journal of proteome research 2008;7(1):352-60.
2008: Claus Sandrine P; Tsang Tsz M; Wang Yulan; Cloarec Olivier; Skordi Eleni; Martin François-Pierre; Rezzi Serge; Ross Alastair; Kochhar Sunil; Holmes Elaine; Nicholson Jeremy K
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.
Molecular systems biology 2008;4():219.
2008: Khaitovich Philipp; Lockstone Helen E; Wayland Matthew T; Tsang Tsz M; Jayatilaka Samantha D; Guo Arfu J; Zhou Jie; Somel Mehmet; Harris Laura W; Holmes Elaine; Pääbo Svante; Bahn Sabine
Metabolic changes in schizophrenia and human brain evolution.
Genome biology 2008;9(8):R124.
2008: Martin Francois-Pierre J; Wang Yulan; Sprenger Norbert; Yap Ivan K S; Rezzi Serge; Ramadan Ziad; Peré-Trepat Emma; Rochat Florence; Cherbut Christine; van Bladeren Peter; Fay Laurent B; Kochhar Sunil; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model.
Molecular systems biology 2008;4():205.
2008: Saric Jasmina; Li Jia V; Wang Yulan; Keiser Jennifer; Bundy Jake G; Holmes Elaine; Utzinger Jürg
Metabolic Profiling of an Echinostoma caproni Infection in the Mouse for Biomarker Discovery.
PLoS neglected tropical diseases 2008;2(7):e254.
2008: Fearnside Jane F; Dumas Marc-Emmanuel; Rothwell Alice R; Wilder Steven P; Cloarec Olivier; Toye Ayo; Blancher Christine; Holmes Elaine; Tatoud Roger; Barton Richard H; Scott James; Nicholson Jeremy K; Gauguier Dominique
Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice.
PloS one 2008;3(2):e1668.
2008: Bylesjö Max; Rantalainen Mattias; Nicholson Jeremy K; Holmes Elaine; Trygg Johan
K-OPLS package: kernel-based orthogonal projections to latent structures for prediction and interpretation in feature space.
BMC bioinformatics 2008;9():106.
2008: Rantalainen Mattias; Cloarec Olivier; Ebbels Timothy M D; Lundstedt Torbjörn; Nicholson Jeremy K; Holmes Elaine; Trygg Johan
Piecewise multivariate modelling of sequential metabolic profiling data.
BMC bioinformatics 2008;9():105.
2008: Martin Francois-Pierre J; Wang Yulan; Sprenger Norbert; Yap Ivan K S; Lundstedt Torbjörn; Lek Per; Rezzi Serge; Ramadan Ziad; van Bladeren Peter; Fay Laurent B; Kochhar Sunil; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model.
Molecular systems biology 2008;4():157.
2007: Coen Muireann; Hong Young-Shick; Cloarec Olivier; Rhode Cindy M; Reily Michael D; Robertson Donald G; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity.
Analytical chemistry 2007;79(23):8956-66.
2007: Skordi Eleni; Yap Ivan K S; Claus Sandrine P; Martin François-Pierre J; Cloarec Olivier; Lindberg Johan; Schuppe-Koistinen Ina; Holmes Elaine; Nicholson Jeremy K
Analysis of time-related metabolic fluctuations induced by ethionine in the rat.
Journal of proteome research 2007;6(12):4572-81.
2007: Ebbels Timothy M D; Keun Hector C; Beckonert Olaf P; Bollard Mary E; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach.
Journal of proteome research 2007;6(11):4407-22.
2007: Wang Yulan; Holmes Elaine; Comelli Elena M; Fotopoulos Grigorios; Dorta Gian; Tang Huiru; Rantalainen Mattias J; Lindon John C; Corthésy-Theulaz Irène E; Fay Laurent B; Kochhar Sunil; Nicholson Jeremy K
Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning 1H NMR spectroscopy.
Journal of proteome research 2007;6(10):3944-51.
2007: Li Jia; Wang Yulan; Fenwick Alan; Clayton T Andrew; Lau Yu Y K; Legido-Quigley Cristina; Lindon John C; Utzinger Jürg; Holmes Elaine
A high-performance liquid chromatography and nuclear magnetic resonance spectroscopy-based analysis of commercially available praziquantel tablets.
Journal of pharmaceutical and biomedical analysis 2007;45(2):263-7.
2007: Smith Leon M; Maher Anthony D; Cloarec Olivier; Rantalainen Mattias; Tang Huiru; Elliott Paul; Stamler Jeremiah; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples.
Analytical chemistry 2007;79(15):5682-9.
2007: Vilasi Annalisa; Cutillas Pedro R; Maher Anthony D; Zirah Severine F M; Capasso Giovambattista; Norden Anthony W G; Holmes Elaine; Nicholson Jeremy K; Unwin Robert J
Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome.
American journal of physiology. Renal physiology 2007;293(2):F456-67.
2007: Coen M; Hong Y S; Clayton T A; Rohde C M; Pearce J T; Reily M D; Robertson D G; Holmes E; Lindon J C; Nicholson J K
The mechanism of galactosamine toxicity revisited; a metabonomic study.
Journal of proteome research 2007;6(7):2711-9.
2007: Maher Anthony D; Zirah Séverine F M; Holmes Elaine; Nicholson Jeremy K
Experimental and analytical variation in human urine in 1H NMR spectroscopy-based metabolic phenotyping studies.
Analytical chemistry 2007;79(14):5204-11.
2007: Teague Claire R; Dhabhar Firdaus S; Barton Richard H; Beckwith-Hall Bridgette; Powell Jonathan; Cobain Mark; Singer Burton; McEwen Bruce S; Lindon John C; Nicholson Jeremy K; Holmes Elaine
Metabonomic studies on the physiological effects of acute and chronic psychological stress in Sprague-Dawley rats.
Journal of proteome research 2007;6(6):2080-93.
2007: Wang Yulan; Lawler Dennis; Larson Brian; Ramadan Ziad; Kochhar Sunil; Holmes Elaine; Nicholson Jeremy K
Metabonomic investigations of aging and caloric restriction in a life-long dog study.
Journal of proteome research 2007;6(5):1846-54.
2007: Holmes Elaine; Loo Ruey Leng; Cloarec Olivier; Coen Muireann; Tang Huiru; Maibaum Elaine; Bruce Stephen; Chan Queenie; Elliott Paul; Stamler Jeremiah; Wilson Ian D; Lindon John C; Nicholson Jeremy K
Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.
Analytical chemistry 2007;79(7):2629-40.
2007: Martin Francois-Pierre J; Wang Yulan; Sprenger Norbert; Holmes Elaine; Lindon John C; Kochhar Sunil; Nicholson Jeremy K
Effects of probiotic Lactobacillus paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy.
Journal of proteome research 2007;6(4):1471-81.
2007: Lindon John C; Holmes Elaine; Nicholson Jeremy K
Metabonomics in pharmaceutical R&D.
The FEBS journal 2007;274(5):1140-51.
2007: Trygg Johan; Holmes Elaine; Lundstedt Torbjörn
Chemometrics in metabonomics.
Journal of proteome research 2007;6(2):469-79.
2007: Holmes E; Nicholson J K
Human metabolic phenotyping and metabolome wide association studies.
Ernst Schering Foundation symposium proceedings 2007;(4):227-49.
2007: Beckonert Olaf; Keun Hector C; Ebbels Timothy M D; Bundy Jacob; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts.
Nature protocols 2007;2(11):2692-703.
2007: Huang Jeffrey T-J; Leweke F Markus; Tsang Tsz M; Koethe Dagmar; Kranaster Laura; Gerth Christoph W; Gross Sonja; Schreiber Daniela; Ruhrmann Stephan; Schultze-Lutter Frauke; Klosterkötter Joachim; Holmes Elaine; Bahn Sabine
CSF metabolic and proteomic profiles in patients prodromal for psychosis.
PloS one 2007;2(1):e756.
2007: Martin François-Pierre J; Dumas Marc-Emmanuel; Wang Yulan; Legido-Quigley Cristina; Yap Ivan K S; Tang Huiru; Zirah Séverine; Murphy Gerard M; Cloarec Olivier; Lindon John C; Sprenger Norbert; Fay Laurent B; Kochhar Sunil; van Bladeren Peter; Holmes Elaine; Nicholson Jeremy K
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.
Molecular systems biology 2007;3():112.
2006: Stella Cinzia; Beckwith-Hall Bridgette; Cloarec Olivier; Holmes Elaine; Lindon John C; Powell Jonathan; van der Ouderaa Frans; Bingham Sheila; Cross Amanda J; Nicholson Jeremy K
Susceptibility of human metabolic phenotypes to dietary modulation.
Journal of proteome research 2006;5(10):2780-8.
2006: Rantalainen Mattias; Cloarec Olivier; Beckonert Olaf; Wilson I D; Jackson David; Tonge Robert; Rowlinson Rachel; Rayner Steve; Nickson Janice; Wilkinson Robert W; Mills Jonathan D; Trygg Johan; Nicholson Jeremy K; Holmes Elaine
Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice.
Journal of proteome research 2006;5(10):2642-55.
2006: Martin Francois-Pierre J; Verdu Elena F; Wang Yulan; Dumas Marc-Emmanuel; Yap Ivan K S; Cloarec Olivier; Bergonzelli Gabriela E; Corthesy-Theulaz Irene; Kochhar Sunil; Holmes Elaine; Lindon John C; Collins Stephen M; Nicholson Jeremy K
Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation.
Journal of proteome research 2006;5(9):2185-93.
2006: Holmes Elaine; Tsang Tsz M; Huang Jeffrey T-J; Leweke F Markus; Koethe Dagmar; Gerth Christoph W; Nolden Brit M; Gross Sonja; Schreiber Daniela; Nicholson Jeremy K; Bahn Sabine
Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia.
PLoS medicine 2006;3(8):e327.
2006: Dumas Marc-Emmanuel; Barton Richard H; Toye Ayo; Cloarec Olivier; Blancher Christine; Rothwell Alice; Fearnside Jane; Tatoud Roger; Blanc Véronique; Lindon John C; Mitchell Steve C; Holmes Elaine; McCarthy Mark I; Scott James; Gauguier Dominique; Nicholson Jeremy K
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12511-6.
2006: Holmes Elaine; Tang Huiru; Wang Yulan; Seger Christoph
The assessment of plant metabolite profiles by NMR-based methodologies.
Planta medica 2006;72(9):771-85.
2006: Craig Andrew; Sidaway James; Holmes Elaine; Orton Terry; Jackson David; Rowlinson Rachel; Nickson Janice; Tonge Robert; Wilson Ian; Nicholson Jeremy
Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.
Journal of proteome research 2006;5(7):1586-601.
2006: Wang Yulan; Holmes Elaine; Tang Huiru; Lindon John C; Sprenger Norbert; Turini Marco E; Bergonzelli Gabriela; Fay Laurent B; Kochhar Sunil; Nicholson Jeremy K
Experimental metabonomic model of dietary variation and stress interactions.
Journal of proteome research 2006;5(7):1535-42.
2006: Holmes Elaine; Tsang Tsz M; Tabrizi Sarah J
The application of NMR-based metabonomics in neurological disorders.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006;3(3):358-72.
2006: Crockford Derek J; Lindon John C; Cloarec Olivier; Plumb Robert S; Bruce Stephen J; Zirah Severine; Rainville Paul; Stumpf Chris L; Johnson Kelly; Holmes Elaine; Nicholson Jeremy K
Statistical search space reduction and two-dimensional data display approaches for UPLC-MS in biomarker discovery and pathway analysis.
Analytical chemistry 2006;78(13):4398-408.
2006: Teahan Orla; Gamble Simon; Holmes Elaine; Waxman Jonathan; Nicholson Jeremy K; Bevan Charlotte; Keun Hector C
Impact of analytical bias in metabonomic studies of human blood serum and plasma.
Analytical chemistry 2006;78(13):4307-18.
2006: Waters Nigel J; Waterfield Catherine J; Farrant R Duncan; Holmes Elaine; Nicholson Jeremy K
Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis.
Journal of proteome research 2006;5(6):1448-59.
2006: Holmes E; Cloarec O; Nicholson J K
Probing latent biomarker signatures and in vivo pathway activity in experimental disease states via statistical total correlation spectroscopy (STOCSY) of biofluids: application to HgCl2 toxicity.
Journal of proteome research 2006;5(6):1313-20.
2006: Lindon John C; Holmes Elaine; Nicholson Jeremy K
Metabonomics techniques and applications to pharmaceutical research & development.
Pharmaceutical research 2006;23(6):1075-88.
2006: Nicholson Jeremy K; Holmes Elaine
Global systems biology and personalized healthcare solutions.
Discovery medicine 2006;6(32):63-70.
2006: Tsang Tsz M; Huang Jeffrey T-J; Holmes Elaine; Bahn Sabine
Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients.
Journal of proteome research 2006;5(4):756-60.
2006: Craig Andrew; Cloarec Olivier; Holmes Elaine; Nicholson Jeremy K; Lindon John C
Scaling and normalization effects in NMR spectroscopic metabonomic data sets.
Analytical chemistry 2006;78(7):2262-7.
2006: Dumas Marc-Emmanuel; Maibaum Elaine C; Teague Claire; Ueshima Hirotsugu; Zhou Beifan; Lindon John C; Nicholson Jeremy K; Stamler Jeremiah; Elliott Paul; Chan Queenie; Holmes Elaine
Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study.
Analytical chemistry 2006;78(7):2199-208.
2006: Tsang Tsz M; Woodman Ben; McLoughlin Gerard A; Griffin Julian L; Tabrizi Sarah J; Bates Gillian P; Holmes Elaine
Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy.
Journal of proteome research 2006;5(3):483-92.
2006: Wang Yulan; Utzinger Jürg; Xiao Shu-Hua; Xue Jian; Nicholson Jeremy K; Tanner Marcel; Singer Burton H; Holmes Elaine
System level metabolic effects of a Schistosoma japonicum infection in the Syrian hamster.
Molecular and biochemical parasitology 2006;146(1):1-9.
2006: Wang Yulan; Bollard Mary E; Nicholson Jeremy K; Holmes Elaine
Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague-Dawley rats using high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue and pattern recognition.
Journal of pharmaceutical and biomedical analysis 2006;40(2):375-81.
2006: Crockford Derek J; Holmes Elaine; Lindon John C; Plumb Robert S; Zirah Severine; Bruce Stephen J; Rainville Paul; Stumpf Chris L; Nicholson Jeremy K
Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies.
Analytical chemistry 2006;78(2):363-71.
2005: Azmi J; Connelly J; Holmes E; Nicholson J K; Shore R F; Griffin J L
Characterization of the biochemical effects of 1-nitronaphthalene in rats using global metabolic profiling by NMR spectroscopy and pattern recognition.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2005;10(6):401-16.
2005: Lindon John C; Keun Hector C; Ebbels Timothy Md; Pearce Jake Mt; Holmes Elaine; Nicholson Jeremy K
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements.
Pharmacogenomics 2005;6(7):691-9.
2005: Holmes Elaine; Nicholson Jeremy
Variation in gut microbiota strongly influences individual rodent phenotypes.
Toxicological sciences : an official journal of the Society of Toxicology 2005;87(1):1-2.
2005: Azmi J; Griffin J L; Shore R F; Holmes E; Nicholson J K
Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(8):839-52.
2005: Stanley E G; Bailey N J C; Bollard M E; Haselden J N; Waterfield C J; Holmes E; Nicholson J K
Sexual dimorphism in urinary metabolite profiles of Han Wistar rats revealed by nuclear-magnetic-resonance-based metabonomics.
Analytical biochemistry 2005;343(2):195-202.
2005: Wang Yulan; Tang Huiru; Holmes Elaine; Lindon John C; Turini Marco E; Sprenger Norbert; Bergonzelli Gabriela; Fay Laurent B; Kochhar Sunil; Nicholson Jeremy K
Biochemical characterization of rat intestine development using high-resolution magic-angle-spinning 1H NMR spectroscopy and multivariate data analysis.
Journal of proteome research 2005;4(4):1324-9.
2005: Crockford D J; Keun H C; Smith L M; Holmes E; Nicholson J K
Curve-fitting method for direct quantitation of compounds in complex biological mixtures using 1H NMR: application in metabonomic toxicology studies.
Analytical chemistry 2005;77(14):4556-62.
2005: Jonsson Par; Bruce Stephen J; Moritz Thomas; Trygg Johan; Sjöström Michael; Plumb Robert; Granger Jennifer; Maibaum Elaine; Nicholson Jeremy K; Holmes Elaine; Antti Henrik
Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets.
The Analyst 2005;130(5):701-7.
2005: Tsang T M; Griffin J L; Haselden J; Fish C; Holmes E
Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;53(5):1018-24.
2005: Nicholson Jeremy K; Holmes Elaine; Wilson Ian D
Gut microorganisms, mammalian metabolism and personalized health care.
Nature reviews. Microbiology 2005;3(5):431-8.
2005: Bollard Mary E; Stanley Elizabeth G; Lindon John C; Nicholson Jeremy K; Holmes Elaine
NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition.
NMR in biomedicine 2005;18(3):143-62.
2005: Waters Nigel J; Waterfield Catherine J; Farrant R Duncan; Holmes Elaine; Nicholson Jeremy K
Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity.
Chemical research in toxicology 2005;18(4):639-54.
2005: Bollard Mary E; Keun Hector C; Beckonert Olaf; Ebbels Tim M D; Antti Henrik; Nicholls Andrew W; Shockcor John P; Cantor Glenn H; Stevens Greg; Lindon John C; Holmes Elaine; Nicholson Jeremy K
Comparative metabonomics of differential hydrazine toxicity in the rat and mouse.
Toxicology and applied pharmacology 2005;204(2):135-51.
2005: Solanky Kirty S; Bailey Nigel J; Beckwith-Hall Bridgette M; Bingham Sheila; Davis Adrienne; Holmes Elaine; Nicholson Jeremy K; Cassidy Aedin
Biofluid 1H NMR-based metabonomic techniques in nutrition research - metabolic effects of dietary isoflavones in humans.
The Journal of nutritional biochemistry 2005;16(4):236-44.
2005: Cloarec Olivier; Dumas Marc-Emmanuel; Craig Andrew; Barton Richard H; Trygg Johan; Hudson Jane; Blancher Christine; Gauguier Dominique; Lindon John C; Holmes Elaine; Nicholson Jeremy
Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.
Analytical chemistry 2005;77(5):1282-9.
2005: Garrod Sarah; Bollard Mary E; Nicholls Andrew W; Connor Susan C; Connelly John; Nicholson Jeremy K; Holmes Elaine
Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat.
Chemical research in toxicology 2005;18(2):115-22.
2005: Wang Yulan; Tang Huiru; Nicholson Jeremy K; Hylands Peter J; Sampson J; Holmes Elaine
A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion.
Journal of agricultural and food chemistry 2005;53(2):191-6.
2005: Cloarec Olivier; Dumas Marc E; Trygg Johan; Craig Andrew; Barton Richard H; Lindon John C; Nicholson Jeremy K; Holmes Elaine
Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies.
Analytical chemistry 2005;77(2):517-26.
2004: Ebbels Timothy M D; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Evaluation of metabolic variation in normal rat strains from a statistical analysis of 1H NMR spectra of urine.
Journal of pharmaceutical and biomedical analysis 2004;36(4):823-33.
2004: Nicholson Jeremy K; Holmes Elaine; Lindon John C; Wilson Ian D
The challenges of modeling mammalian biocomplexity.
Nature biotechnology 2004;22(10):1268-74.
2004: Eriksson Lennart; Antti Henrik; Gottfries Johan; Holmes Elaine; Johansson Erik; Lindgren Fredrik; Long Ingrid; Lundstedt Torbjörn; Trygg Johan; Wold Svante
Using chemometrics for navigating in the large data sets of genomics, proteomics, and metabonomics (gpm).
Analytical and bioanalytical chemistry 2004;380(3):419-29.
2004: Wang Yulan; Holmes Elaine; Nicholson Jeremy K; Cloarec Olivier; Chollet Jacques; Tanner Marcel; Singer Burton H; Utzinger Jürg
Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12676-81.
2004: Lindon John C; Holmes Elaine; Nicholson Jeremy K
Metabonomics: systems biology in pharmaceutical research and development.
Current opinion in molecular therapeutics 2004;6(3):265-72.
2004: Keun Hector C; Ebbels Timothy M D; Bollard Mary E; Beckonert Olaf; Antti Henrik; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles.
Chemical research in toxicology 2004;17(5):579-87.
2004: Bailey Nigel J C; Wang Yulan; Sampson Julia; Davis Wendy; Whitcombe Ian; Hylands Peter J; Croft Simon L; Holmes Elaine
Prediction of anti-plasmodial activity of Artemisia annua extracts: application of 1H NMR spectroscopy and chemometrics.
Journal of pharmaceutical and biomedical analysis 2004;35(1):117-26.
2004: Wang Yulan; Tang Huiru; Nicholson Jeremy K; Hylands Peter J; Sampson Julia; Whitcombe Ian; Stewart Christopher G; Caiger Steve; Oru Isaac; Holmes Elaine
Metabolomic strategy for the classification and quality control of phytomedicine: a case study of chamomile flower (Matricaria recutita L.).
Planta medica 2004;70(3):250-5.
2004: Lindon John C; Holmes Elaine; Nicholson Jeremy K
Metabonomics and its role in drug development and disease diagnosis.
Expert review of molecular diagnostics 2004;4(2):189-99.
2004: Teague Claire; Holmes Elaine; Maibaum Elaine; Nicholson Jeremy; Tang Huiru; Chan Queenie; Elliott Paul; Stamler Jeremiah; Ueshima Hirotsugu; Zhou Beifan; Wilson Ian
Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans.
The Analyst 2004;129(3):259-64.
2004: Lindon John C; Holmes Elaine; Bollard Mary E; Stanley Elizabeth G; Nicholson Jeremy K
Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2004;9(1):1-31.
2003: Solanky Kirty S; Bailey Nigel J C; Beckwith-Hall Bridgette M; Davis Adrienne; Bingham Sheila; Holmes Elaine; Nicholson Jeremy K; Cassidy Aedin
Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile.
Analytical biochemistry 2003;323(2):197-204.
2003: Wang Yulan; Bollard Mary E; Keun Hector; Antti Henrik; Beckonert Olaf; Ebbels Timothy M; Lindon John C; Holmes Elaine; Tang Huiru; Nicholson Jeremy K
Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues.
Analytical biochemistry 2003;323(1):26-32.
2003: Lindon John C; Holmes Elaine; Nicholson Jeremy K
So what's the deal with metabonomics?
Analytical chemistry 2003;75(17):384A-391A.
2003: Beckwith-Hall Bridgette M; Thompson Nicholas A; Nicholson Jeremy K; Lindon John C; Holmes Elaine
A metabonomic investigation of hepatotoxicity using diffusion-edited 1H NMR spectroscopy of blood serum.
The Analyst 2003;128(7):814-8.
2003: Solanky Kirty S; Bailey Nigel J C; Holmes Elaine; Lindon John C; Davis Adrienne L; Mulder Theo P J; Van Duynhoven John P M; Nicholson Jeremy K
NMR-based metabonomic studies on the biochemical effects of epicatechin in the rat.
Journal of agricultural and food chemistry 2003;51(14):4139-45.
2003: Lindon John C; Nicholson Jeremy K; Holmes Elaine; Antti Henrik; Bollard Mary E; Keun Hector; Beckonert Olaf; Ebbels Timothy M; Reily Michael D; Robertson Donald; Stevens Gregory J; Luke Peter; Breau Alan P; Cantor Glenn H; Bible Roy H; Niederhauser Urs; Senn Hans; Schlotterbeck Goetz; Sidelmann Ulla G; Laursen Steen M; Tymiak Adrienne; Car Bruce D; Lehman-McKeeman Lois; Colet Jean Marie; Loukaci Ali; Thomas Craig
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
Toxicology and applied pharmacology 2003;187(3):137-46.
2003: Bailey Nigel J C; Oven Matjaz; Holmes Elaine; Nicholson Jeremy K; Zenk Meinhart H
Metabolomic analysis of the consequences of cadmium exposure in Silene cucubalus cell cultures via 1H NMR spectroscopy and chemometrics.
Phytochemistry 2003;62(6):851-8.
2003: Brindle Joanne T; Nicholson Jeremy K; Schofield Peter M; Grainger David J; Holmes Elaine
Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension.
The Analyst 2003;128(1):32-6.
2002: Holmes E; Antti H
Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra.
The Analyst 2002;127(12):1549-57.
2002: Brindle Joanne T; Antti Henrik; Holmes Elaine; Tranter George; Nicholson Jeremy K; Bethell Hugh W L; Clarke Sarah; Schofield Peter M; McKilligin Elaine; Mosedale David E; Grainger David J
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics.
Nature medicine 2002;8(12):1439-44.
2002: Connelly John C; Connor Susan C; Monte Soria; Bailey Nigel J C; Borgeaud Nathan; Holmes Elaine; Troke Jeff; Nicholson Jeremy K; Gavaghan Claire L
Application of directly coupled high performance liquid chromatography-NMR-mass spectometry and 1H NMR spectroscopic studies to the investigation of 2,3-benzofuran metabolism in Sprague-Dawley rats.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(12):1357-63.
2002: Keun Hector C; Ebbels Timothy M D; Antti Henrik; Bollard Mary E; Beckonert Olaf; Schlotterbeck Götz; Senn Hans; Niederhauser Urs; Holmes Elaine; Lindon John C; Nicholson Jeremy K
Analytical reproducibility in (1)H NMR-based metabonomic urinalysis.
Chemical research in toxicology 2002;15(11):1380-6.
2002: Bollard Mary E; Xu Jinsheng; Purcell Wendy; Griffin Julian L; Quirk Christopher; Holmes Elaine; Nicholson Jeremy K
Metabolic profiling of the effects of D-galactosamine in liver spheroids using (1)H NMR and MAS-NMR spectroscopy.
Chemical research in toxicology 2002;15(11):1351-9.
2002: Beckwith-Hall Bridgette M; Brindle Joanne T; Barton Richard H; Coen Muireann; Holmes Elaine; Nicholson Jeremy K; Antti Henrik
Application of orthogonal signal correction to minimise the effects of physical and biological variation in high resolution 1H NMR spectra of biofluids.
The Analyst 2002;127(10):1283-8.
2002: Mitchell Steve; Holmes Elaine; Carmichael Paul
Metabonomics and medicine: the Biochemical Oracle.
Biologist (London, England) 2002;49(5):217-21.
2002: Beckwith-Hall Bridgette M; Holmes Elaine; Lindon John C; Gounarides John; Vickers Alison; Shapiro Michael; Nicholson Jeremy K
NMR-based metabonomic studies on the biochemical effects of commonly used drug carrier vehicles in the rat.
Chemical research in toxicology 2002;15(9):1136-41.
2002: Bailey Nigel J C; Sampson Julia; Hylands Peter J; Nicholson Jeremy K; Holmes Elaine
Multi-component metabolic classification of commercial feverfew preparations via high-field 1H-NMR spectroscopy and chemometrics.
Planta medica 2002;68(8):734-8.
2002: Waters Nigel J; Holmes Elaine; Waterfield Catherine J; Farrant R Duncan; Nicholson Jeremy K
NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate.
Biochemical pharmacology 2002;64(1):67-77.
2002: Scarfe G B; Wilson I D; Warne M A; Holmes E; Nicholson J K; Lindon J C
Structure-metabolism relationships of substituted anilines: prediction of N-acetylation and N-oxanilic acid formation using computational chemistry.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(4):267-77.
2002: Nicholson Jeremy K; Connelly John; Lindon John C; Holmes Elaine
Metabonomics: a platform for studying drug toxicity and gene function.
Nature reviews. Drug discovery 2002;1(2):153-61.
2002: Azmi Jahanara; Griffin Julian L; Antti Henrik; Shore Richard F; Johansson Erik; Nicholson Jeremy K; Holmes Elaine
Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data.
The Analyst 2002;127(2):271-6.
2002: Shockcor John P; Holmes Elaine
Metabonomic applications in toxicity screening and disease diagnosis.
Current topics in medicinal chemistry 2002;2(1):35-51.
2002: Talbert Ann M; Tranter George E; Holmes Elaine; Francis Peter L
Determination of drug-plasma protein binding kinetics and equilibria by chromatographic profiling: exemplification of the method using L-tryptophan and albumin.
Analytical chemistry 2002;74(2):446-52.
2001: Waters N J; Holmes E; Williams A; Waterfield C J; Farrant R D; Nicholson J K
NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach.
Chemical research in toxicology 2001;14(10):1401-12.
2001: Nicholls A W; Holmes E; Lindon J C; Shockcor J P; Farrant R D; Haselden J N; Damment S J; Waterfield C J; Nicholson J K
Metabonomic investigations into hydrazine toxicity in the rat.
Chemical research in toxicology 2001;14(8):975-87.
2001: Bollard M E; Holmes E; Lindon J C; Mitchell S C; Branstetter D; Zhang W; Nicholson J K
Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition.
Analytical biochemistry 2001;295(2):194-202.
2001: Coen M; Lindon J C; Gavaghan C; Holmes E; Humpfer E; Wilson I D; Stanley P D; Nicholson J K
Investigation of water environments in a C18 bonded silica phase using 1H magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy.
The Analyst 2001;126(5):548-50.
2001: Garrod S; Humpher E; Connor S C; Connelly J C; Spraul M; Nicholson J K; Holmes E
High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;45(5):781-90.
2001: Gavaghan C L; Nicholson J K; Connor S C; Wilson I D; Wright B; Holmes E
Directly coupled high-performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague--Dawley rats.
Analytical biochemistry 2001;291(2):245-52.
2001: Holmes E; Nicholson J K; Tranter G
Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks.
Chemical research in toxicology 2001;14(2):182-91.
2000: Griffin J L; Walker L A; Garrod S; Holmes E; Shore R F; Nicholson J K
NMR spectroscopy based metabonomic studies on the comparative biochemistry of the kidney and urine of the bank vole (Clethrionomys glareolus), wood mouse (Apodemus sylvaticus), white toothed shrew (Crocidura suaveolens) and the laboratory rat.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2000;127(3):357-67.
2000: Bollard M E; Garrod S; Holmes E; Lindon J C; Humpfer E; Spraul M; Nicholson J K
High-resolution (1)H and (1)H-(13)C magic angle spinning NMR spectroscopy of rat liver.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;44(2):201-7.
2000: Waters N J; Garrod S; Farrant R D; Haselden J N; Connor S C; Connelly J; Lindon J C; Holmes E; Nicholson J K
High-resolution magic angle spinning (1)H NMR spectroscopy of intact liver and kidney: optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition.
Analytical biochemistry 2000;282(1):16-23.
2000: Holmes E; Nicholls A W; Lindon J C; Connor S C; Connelly J C; Haselden J N; Damment S J; Spraul M; Neidig P; Nicholson J K
Chemometric models for toxicity classification based on NMR spectra of biofluids.
Chemical research in toxicology 2000;13(6):471-8.
2000: Tate A R; Foxall P J; Holmes E; Moka D; Spraul M; Nicholson J K; Lindon J C
Distinction between normal and renal cell carcinoma kidney cortical biopsy samples using pattern recognition of (1)H magic angle spinning (MAS) NMR spectra.
NMR in biomedicine 2000;13(2):64-71.
1999: Nicholson J K; Lindon J C; Holmes E
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(11):1181-9.
1999: Garrod S; Humpfer E; Spraul M; Connor S C; Polley S; Connelly J; Lindon J C; Nicholson J K; Holmes E
High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;41(6):1108-18.
1999: Cupid B C; Holmes E; Wilson I D; Lindon J C; Nicholson J K
Quantitative structure-metabolism relationships (QSMR) using computational chemistry: pattern recognition analysis and statistical prediction of phase II conjugation reactions of substituted benzoic acids in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(1):27-42.
1998: Holmes E; Nicholls A W; Lindon J C; Ramos S; Spraul M; Neidig P; Connor S C; Connelly J; Damment S J; Haselden J; Nicholson J K
Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition.
NMR in biomedicine 1998;11(4-5):235-44.
1998: Beckwith-Hall B M; Nicholson J K; Nicholls A W; Foxall P J; Lindon J C; Connor S C; Abdi M; Connelly J; Holmes E
Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins.
Chemical research in toxicology 1998;11(4):260-72.
1997: Holmes E; Foxall P J; Spraul M; Farrant R D; Nicholson J K; Lindon J C
750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease.
Journal of pharmaceutical and biomedical analysis 1997;15(11):1647-59.
1997: Holmes E; Bonner F W; Nicholson J K
1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat and the multimammate desert mouse (Mastomys natalensis).
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1997;116(2):125-34.
1996: Holmes E; Bonner F W; Nicholson J K
Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the multimammate mouse (Mastomys natalensis).
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1996;114(1):7-15.
1996: Bollard M E; Holmes E; Blackledge C A; Lindon J C; Wilson I D; Nicholson J K
1H and 19F-nmr spectroscopic studies on the metabolism and urinary excretion of mono- and disubstituted phenols in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(3):255-73.
1995: Holmes E; Sweatman B C; Bollard M E; Blackledge C A; Beddell C R; Wilson I D; Lindon J C; Nicholson J K
Prediction of urinary sulphate and glucuronide conjugate excretion for substituted phenols in the rat using quantitative structure-metabolism relationships.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(12):1269-81.
1995: Anthony M L; Holmes E; McDowell P C; Gray T J; Blackmore M; Nicholson J K
1H NMR spectroscopic studies on the reactions of haloalkylamines with bicarbonate ions: formation of N-carbamates and 2-oxazolidones in cell culture media and blood plasma.
Chemical research in toxicology 1995;8(8):1046-53.
1995: Holmes E; Caddick S; Lindon J C; Wilson I D; Kryvawych S; Nicholson J K
1H and 2H NMR spectroscopic studies on the metabolism and biochemical effects of 2-bromoethanamine in the rat.
Biochemical pharmacology 1995;49(10):1349-59.
1995: Holmes E; Bonner F W; Nicholson J K
Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis).
Archives of toxicology 1995;70(2):89-95.
1994: Spraul M; Neidig P; Klauck U; Kessler P; Holmes E; Nicholson J K; Sweatman B C; Salman S R; Farrant R D; Rahr E
Automatic reduction of NMR spectroscopic data for statistical and pattern recognition classification of samples.
Journal of pharmaceutical and biomedical analysis 1994;12(10):1215-25.
1994: Holmes E; Foxall P J; Nicholson J K; Neild G H; Brown S M; Beddell C R; Sweatman B C; Rahr E; Lindon J C; Spraul M
Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine from normal and pathological states.
Analytical biochemistry 1994;220(2):284-96.
1993: Sweatman B C; Farrant R D; Holmes E; Ghauri F Y; Nicholson J K; Lindon J C
600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances.
Journal of pharmaceutical and biomedical analysis 1993;11(8):651-64.
1992: Holmes E; Nicholson J K; Bonner F W; Sweatman B C; Beddell C R; Lindon J C; Rahr E
Mapping the biochemical trajectory of nephrotoxicity by pattern recognition of NMR urinanalysis.
NMR in biomedicine 1992;5(6):368-72.
1992: Holmes E; Bonner F W; Sweatman B C; Lindon J C; Beddell C R; Rahr E; Nicholson J K
Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine.
Molecular pharmacology 1992;42(5):922-30.
1990: Holmes E; Foxall P J; Nicholson J K
Proton NMR analysis of plasma from renal failure patients: evaluation of sample preparation and spectral-editing methods.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):955-8.
1990: Holmes E; Bonner F W; Gartland K P; Nicholson J K
Proton NMR monitoring of the onset and recovery of experimental renal damage.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):959-62.

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