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Elaine Holmes

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Claire Alexandra Merrifield; Jeremy Kirk Nicholson; Jake Thomas Midwinter Pearce; Francois-Pierre Martin; Mick Bailey; Sandrine Paule Claus; Olivier Cloarec; Marc-Emmanuel Dumas; Swantje Duncker; Silke Sophie Heinzmann; Sunil Kochhar; Marie Claire Lewis; Annick Mercenier; Elaine Holmes
Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818.
Judith M Fonville; Rian L Griffiths; Elaine Holmes; Patricia F Lalor; John C Lindon; Jeremy K Nicholson; Andrew D Palmer; Luis Pizarro; Rory T Steven; Claire L Carter; Josephine Bunch
Hyperspectral visualization of mass spectrometry imaging data.
Beatriz Jiménez; Hector C Keun; James Kinross; Reza Mirnezami; Olivier Cloarec; Ara Darzi; Robert D Goldin; Elaine Holmes; Paul Ziprin; Jeremy K Nicholson
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.

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2013: Claire Alexandra Merrifield; Jeremy Kirk Nicholson; Jake Thomas Midwinter Pearce; Francois-Pierre Martin; Mick Bailey; Sandrine Paule Claus; Olivier Cloarec; Marc-Emmanuel Dumas; Swantje Duncker; Silke Sophie Heinzmann; Sunil Kochhar; Marie Claire Lewis; Annick Mercenier; Elaine Holmes
Weaning diet induces sustained metabolic phenotype shift in the pig and influences host response to Bifidobacterium lactis NCC2818.
Gut 2013;62(6):842-51.
2013: Judith M Fonville; Rian L Griffiths; Elaine Holmes; Patricia F Lalor; John C Lindon; Jeremy K Nicholson; Andrew D Palmer; Luis Pizarro; Rory T Steven; Claire L Carter; Josephine Bunch
Hyperspectral visualization of mass spectrometry imaging data.
Analytical chemistry 2013;85(3):1415-23.
2013: Beatriz Jiménez; Hector C Keun; James Kinross; Reza Mirnezami; Olivier Cloarec; Ara Darzi; Robert D Goldin; Elaine Holmes; Paul Ziprin; Jeremy K Nicholson
1H HR-MAS NMR spectroscopy of tumor-induced local metabolic "field-effects" enables colorectal cancer staging and prognostication.
Journal of proteome research 2013;12(2):959-68.
2013: Elizabeth J Want; Ian D Wilson; Robert S Plumb; John P Shockcor; Georgios Theodoridis; Elaine Holmes; Neil Loftus; Perrine Masson; Filippos Michopoulos; Jeremy K Nicholson
Global metabolic profiling of animal and human tissues via UPLC-MS.
Nature protocols 2013;8(1):17-32.
2013: G H Cantor; G L Cockerell; Timothy M D Ebbels; Elaine Holmes; Hector C Keun; John C Lindon; Henrik Antti; Olaf Beckonert; Roy H Bible; Mary E Bollard; Alan P Breau; J A Wijsman; Jeremy K Nicholson
Integrated histopathological and urinary metabonomic investigation of the pathogenesis of microcystin-LR toxicosis.
Veterinary pathology 2013;50(1):159-71.
2012: Joram M Posma; Maria De Iorio; Timothy M D Ebbels; Paul Elliott; Isabel Garcia Perez; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Subset optimization by reference matching (STORM): an optimized statistical approach for recovery of metabolic biomarker structural information from 1H NMR spectra of biofluids.
Analytical chemistry 2012;84(24):10694-701.
2012: Jeremy K Nicholson; Zoltan Takats; Ara W Darzi; Elaine Holmes; James M Kinross; John C Lindon
Metabolic phenotyping in clinical and surgical environments.
Nature 2012;491(7424):384-92.
2012: Elaine Holmes; Jia V Li; Julian R Marchesi; Jeremy K Nicholson
Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk.
Cell metabolism 2012;16(5):559-64.
2012: Katharine Cunningham; Jeremy R Everett; Elaine Holmes; John C Lindon; Jeremy K Nicholson; Sandrine P Claus; Muireann Coen
Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response.
Journal of proteome research 2012;11(9):4630-42.
2012: Isabel Garcia Perez; Peter Aronson; Coral Barbas; Paul Elliott; Zhirong Jiang; Jeremy Nicholson; Joram M Posma; Jeremiah Stamler; Robert Unwin; Alma Villaseñor; Anisha Wijeyesekera; Elaine Holmes
Urinary metabolic phenotyping the slc26a6 (chloride-oxalate exchanger) null mouse model.
Journal of proteome research 2012;11(9):4425-35.
2012: Jasmina Saric; John P Shockcor; Elizabeth J Want; Urs Duthaler; Elaine Holmes; Jennifer Keiser; Matthew Lewis; Jeremy K Nicholson; Gordon A Ross; Marina F M Tavares
Systematic evaluation of extraction methods for multiplatform-based metabotyping: application to the Fasciola hepatica metabolome.
Analytical chemistry 2012;84(16):6963-72.
2012: Liping Zhao; Elaine Holmes; Jia V Li; Aiping Lu; Jeremy K Nicholson; Jian Shen; Huiru Tang; Zhengtao Wang; Xu Zhang; John C Lindon
Targeting the human genome-microbiome axis for drug discovery: inspirations from global systems biology and traditional Chinese medicine.
Journal of proteome research 2012;11(7):3509-19.
2012: Agnes Ernst; Isabel Garcia-Perez; Paul C Guest; Elaine Holmes; Wolfgang Kluge; Dan Ma; Zoltan Sarnyai; Emanuel Schwarz; Tsz M Tsang; Sabine Bahn
Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission.
Journal of proteome research 2012;11(7):3704-14.
2012: Jeremy K Nicholson; Remy Burcelin; Glenn Gibson; Elaine Holmes; Wei Jia; James Kinross; Sven Pettersson
Host-gut microbiota metabolic interactions.
Science (New York, N.Y.) 2012;336(6086):1262-7.
2012: Elaine Holmes; Wei Jia; James Kinross; Remy Burcelin; Glenn R Gibson; Sven Pettersson; Jeremy K Nicholson
Therapeutic modulation of microbiota-host metabolic interactions.
Science translational medicine 2012;4(137):137rv6.
2012: Muireann Coen; Françoise Goldfain-Blanc; Elaine Holmes; John C Lindon; Donald G Robertson; Gaëlle Rolland-Valognes; Bernard Walther; Jeremy K Nicholson
Pharmacometabonomic investigation of dynamic metabolic phenotypes associated with variability in response to galactosamine hepatotoxicity.
Journal of proteome research 2012;11(4):2427-40.
2012: Anisha Wijeyesekera; Richard H Barton; Elaine Holmes; Jeremy K Nicholson; Colin Selman; Dominic J Withers
Metabotyping of long-lived mice using 1H NMR spectroscopy.
Journal of proteome research 2012;11(4):2224-35.
2012: H Paul Benton; Alexander Amberg; Francoise Goldfain-Blanc; Elaine Holmes; Hector C Keun; John C Lindon; Jeremy K Nicholson; Robert S Plumb; Michael D Reily; Bernhard Walther; Elizabeth Want; Timothy M D Ebbels
Intra- and interlaboratory reproducibility of ultra performance liquid chromatography-time-of-flight mass spectrometry for urinary metabolic profiling.
Analytical chemistry 2012;84(5):2424-32.
2012: Judith M Fonville; Josephine Bunch; Claire Carter; Olivier Cloarec; John C Lindon; Jeremy K Nicholson; Elaine Holmes
Robust data processing and normalization strategy for MALDI mass spectrometric imaging.
Analytical chemistry 2012;84(3):1310-9.
2012: Silke S Heinzmann; Elaine Holmes; Sunil Kochhar; John C Lindon; Claire A Merrifield; Francois-Pierre Martin; Jeremy K Nicholson
Stability and robustness of human metabolic phenotypes in response to sequential food challenges.
Journal of proteome research 2012;11(2):643-55.
2012: Steven L Robinette; Elaine Holmes; Jeremy K Nicholson; Marc E Dumas
Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations.
Genome medicine 2012;4(4):30.
2011: M K Chan; P C Guest; L W Harris; Elaine Holmes; Tsz M Tsang; Sabine Bahn
Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients.
Molecular psychiatry 2011;16(12):1189-202.
2011: Enea Rezzonico; Séverine Combremont; Michèle Delley; Marc-Emmanuel Dumas; Elaine Holmes; Renaud Mestdagh; Jeremy Nicholson; Rodrigo Bibiloni
Bacterial adaptation to the gut environment favors successful colonization: microbial and metabonomic characterization of a simplified microbiota mouse model.
Gut microbes 2011;2(6):307-18.
2011: E Louise Thomas; Ivan K S Yap; James R Parkinson; Jimmy D Bell; Caroline J Doré; Elaine Holmes; Matthew J Hyde; Neena Modi
Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant.
Pediatric research 2011;70(5):507-12.
2011: Judith M Fonville; Elaine Holmes; John C Lindon; Jeremy K Nicholson; Max Bylesjö; Muireann Coen; Mattias Rantalainen
Non-linear modeling of 1H NMR metabonomic data using kernel-based orthogonal projections to latent structures optimized by simulated annealing.
Analytica chimica acta 2011;705(1-2):72-80.
2011: William M B Edmands; Olaf Beckonert; Alison Campbell; Elaine Holmes; Brian G Lake; John C Lindon; Cinzia Stella; Nigel J Gooderham
Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling.
Journal of proteome research 2011;10(10):4513-21.
2011: George Nicholson; Jeremy K Nicholson; Mattias Rantalainen; N William Rayner; Ugis Sarkans; Tim D Spector; Karsten Suhre; Henrik Toft; Juris Viksna; Krina T Zondervan; Jerzy Adamski; Kourosh R Ahmadi; Maxine Allen; Amy Barrett; Dorrit Baunsgaard; Peter Donnelly; Marc-Emmanuel Dumas; Johan H Faber; Elaine Holmes; Thomas Illig; Maria Krestyaninova; Jia V Li; John C Lindon; Anthony D Maher; Daniel Malmodin; Mark I McCarthy; Josine L Min; Sudeshna Guha Neogi; Chris C Holmes
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
PLoS genetics 2011;7(9):e1002270.
2011: Claire A Merrifield; Francois-Pierre Martin; Mick Bailey; Olaf P Beckonert; Sandrine P Claus; Marc-Emmanuel Dumas; Swantje Duncker; Elaine Holmes; Sunil Kochhar; Marie Lewis; John C Lindon; Jeremy K Nicholson
A metabolic system-wide characterisation of the pig: a model for human physiology.
Molecular bioSystems 2011;7(9):2577-88.
2011: Jia V Li; Julian R Marchesi; Jeremy K Nicholson; Caroline Sands; Hutan Ashrafian; Thanos Athanasiou; Stephen R Bloom; Marco Bueter; Ara Darzi; James Kinross; Carel W le Roux; Elaine Holmes
Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk.
Gut 2011;60(9):1214-23.
2011: Jonathan R Swann; Kieran Tuohy; Ian D Wilson; Duncan T Brown; Glenn R Gibson; Peter Lindfors; Jeremy K Nicholson; James Sidaway; Elaine Holmes
Variation in antibiotic-induced microbial recolonization impacts on the host metabolic phenotypes of rats.
Journal of proteome research 2011;10(8):3590-603.
2011: Cristina Legido-Quigley; John C Lindon; Lindsay McDermott; Gerard M Murphy; Jeremy K Nicholson; Hector Vilca-Melendez; Nigel Heaton; Elaine Holmes
Bile UPLC-MS fingerprinting and bile acid fluxes during human liver transplantation.
Electrophoresis 2011;32(15):2063-70.
2011: Kirill A Veselkov; Lisa K Vingara; Bernard Walther; Elizabeth Want; István Pelczer; Steven L Robinette; Richard H Barton; Claire Boursier-Neyret; Timothy M D Ebbels; Elaine Holmes; Jia V Li; John C Lindon; Perrine Masson; Jeremy K Nicholson
Optimized preprocessing of ultra-performance liquid chromatography/mass spectrometry urinary metabolic profiles for improved information recovery.
Analytical chemistry 2011;83(15):5864-72.
2011: Elaine Holmes; Jia V Li; Hutan Ashrafian; Thanos Athanasiou; Jeremy K Nicholson
Understanding the role of gut microbiome-host metabolic signal disruption in health and disease.
Trends in microbiology 2011;19(7):349-59.
2011: James M Kinross; Elaine Holmes; Ara W Darzi; Jeremy K Nicholson
Metabolic phenotyping for monitoring surgical patients.
Lancet 2011;377(9780):1817-9.
2011: Hutan Ashrafian; Kamran Ahmed; Simon P Rowland; Vanash M Patel; Nigel J Gooderham; Elaine Holmes; Ara Darzi; Thanos Athanasiou
Metabolic surgery and cancer: protective effects of bariatric procedures.
Cancer 2011;117(9):1788-99.
2011: Claire Gavaghan; Jia V Li; Stephen T Hadfield; Stephen Hole; Jeremy K Nicholson; Ian D Wilson; Peter W A Howe; Paul D Stanley; Elaine Holmes
Application of NMR-based metabolomics to the investigation of salt stress in maize (Zea mays).
Phytochemical analysis : PCA 2011;22(3):214-24.
2011: Houman Ashrafian; Thanos Athanasiou; J V Li; Marco Bueter; Kamran Ahmed; K Nagpal; Elaine Holmes; Ara Darzi; Stephen R Bloom
Diabetes resolution and hyperinsulinaemia after metabolic Roux-en-Y gastric bypass.
Obesity reviews : an official journal of the International Association for the Study of Obesity 2011;12(5):e257-72.
2011: Caroline J Sands; Muireann Coen; Timothy M D Ebbels; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Data-driven approach for metabolite relationship recovery in biological 1H NMR data sets using iterative statistical total correlation spectroscopy.
Analytical chemistry 2011;83(6):2075-82.
2011: Jonathan R Swann; Elizabeth J Want; Florian M Geier; Konstantina Spagou; Ian D Wilson; James E Sidaway; Jeremy K Nicholson; Elaine Holmes
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments.
Proceedings of the National Academy of Sciences of the United States of America 2011;108 Suppl 1():4523-30.
2011: Marc Chadeau-Hyam; Toby J Athersuch; Hector C Keun; Maria De Iorio; Timothy M D Ebbels; Mazda Jenab; Carlotta Sacerdote; Stephen J Bruce; Elaine Holmes; Paolo Vineis
Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2011;16(1):83-8.
2011: Jia V Li; Julian R Marchesi; Jeremy K Nicholson; Reshat Reshat; Qianxin Wu; Hutan Ashrafian; Thanos Athanasiou; Marco Bueter; Ara Darzi; Elaine Holmes; Carel W le Roux; Nigel J Gooderham
Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents.
Frontiers in microbiology 2011;2():183.
2011: Jia V Li; Jasmina Saric; Jürg Utzinger; Yulan Wang; Jennifer Keiser; Elaine Holmes
Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni.
Parasites & vectors 2011;4():179.
2011: George Nicholson; Jeremy K Nicholson; Mattias Rantalainen; Ugis Sarkans; Bernard W Silverman; Tim D Spector; Henrik Toft; Juris Viksna; Krina T Zondervan; Kourosh R Ahmadi; Maxine Allen; Amy Barrett; Dorrit Baunsgaard; Peter Donnelly; Marc-Emmanuel Dumas; Johan H Faber; Ingileif B Hallgrímsdóttir; Elaine Holmes; Maria Krestyaninova; Jia V Li; John C Lindon; Anthony D Maher; Daniel Malmodin; Mark I McCarthy; Sudeshna Guha Neogi; Chris C Holmes
Human metabolic profiles are stably controlled by genetic and environmental variation.
Molecular systems biology 2011;7():525.
2011: Sandrine P Claus; Sandrine L Ellero; Bernard Berger; Lutz Krause; Anne Bruttin; Jérôme Molina; Alain Paris; Elizabeth J Want; Isabelle de Waziers; Olivier Cloarec; Selena E Richards; Yulan Wang; Marc-Emmanuel Dumas; Alastair Ross; Francois-Pierre Martin; Sunil Kochhar; Peter Van Bladeren; John C Lindon; Elaine Holmes; Jeremy K Nicholson
Colonization-induced host-gut microbial metabolic interaction.
mBio 2011;2(2):e00271-10.
2011: Jia V Li; Jasmina Saric; Yulan Wang; Jürg Utzinger; Elaine Holmes; Oliver Balmer
Metabonomic investigation of single and multiple strain Trypanosoma brucei brucei infections.
The American journal of tropical medicine and hygiene 2011;84(1):91-8.
2011: Konstantina Spagou; Ian D Wilson; Perrine Masson; Georgios Theodoridis; Nikolaos Raikos; Muireann Coen; Elaine Holmes; John C Lindon; Robert S Plumb; Jeremy K Nicholson; Elizabeth J Want
HILIC-UPLC-MS for exploratory urinary metabolic profiling in toxicological studies.
Analytical chemistry 2011;83(1):382-90.
2010: Ivan K S Yap; Ian J Brown; Queenie Chan; Anisha Wijeyesekera; Isabel Garcia-Perez; Magda Bictash; Ruey Leng Loo; Marc Chadeau-Hyam; Timothy M D Ebbels; Maria De Iorio; Elaine Maibaum; Liancheng Zhao; Hugo Kesteloot; Martha L Daviglus; Jeremiah Stamler; Jeremy K Nicholson; Paul Elliott; Elaine Holmes
Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study.
Journal of proteome research 2010;9(12):6647-54.
2010: Marc Chadeau-Hyam; Timothy M D Ebbels; Ian J Brown; Queenie Chan; Jeremiah Stamler; Chiang-Ching Huang; Martha L Daviglus; Hirotsugu Ueshima; Liancheng Zhao; Elaine Holmes; Jeremy K Nicholson; Paul Elliott; Maria De Iorio
Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification.
Journal of proteome research 2010;9(9):4620-7.
2010: Magda Bictash; Timothy M D Ebbels; Queenie Chan; Ruey Leng Loo; Ivan K S Yap; Ian J Brown; Maria De Iorio; Martha L Daviglus; Elaine Holmes; Jeremiah Stamler; Jeremy K Nicholson; Paul Elliott
Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology.
Journal of clinical epidemiology 2010;63(9):970-9.
2010: Silke S Heinzmann; Ian J Brown; Queenie Chan; Magda Bictash; Marc-Emmanuel Dumas; Sunil Kochhar; Jeremiah Stamler; Elaine Holmes; Paul Elliott; Jeremy K Nicholson
Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption.
The American journal of clinical nutrition 2010;92(2):436-43.
2010: Elaine Holmes
The evolution of metabolic profiling in parasitology.
Parasitology 2010;137(9):1437-49.
2010: Kirill A Veselkov; Valeriy I Pahomov; John C Lindon; Vladimir S Volynkin; Derek Crockford; George S Osipenko; David B Davies; Richard H Barton; Jung-Wook Bang; Elaine Holmes; Jeremy K Nicholson
A metabolic entropy approach for measurements of systemic metabolic disruptions in patho-physiological States.
Journal of proteome research 2010;9(7):3537-44.
2010: Jasmina Saric; Jia V Li; Jürg Utzinger; Yulan Wang; Jennifer Keiser; Stephan Dirnhofer; Olaf Beckonert; Mansour T A Sharabiani; Judith M Fonville; Jeremy K Nicholson; Elaine Holmes
Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain.
Molecular systems biology 2010;6():396.
2010: Isabel Garcia Perez; Santiago Angulo; Jürg Utzinger; Elaine Holmes; Cristina Legido-Quigley; Coral Barbas
Chemometric and biological validation of a capillary electrophoresis metabolomic experiment of Schistosoma mansoni infection in mice.
Electrophoresis 2010;31(14):2338-48.
2010: Cristina Legido-Quigley; Cinzia Stella; Francisco Perez-Jimenez; Jose Lopez-Miranda; Jose Ordovas; Jonathan Powell; Frans van der Ouderaa; Lisa Ware; John C Lindon; Jeremy K Nicholson; Elaine Holmes
Liquid chromatography-mass spectrometry methods for urinary biomarker detection in metabonomic studies with application to nutritional studies.
Biomedical chromatography : BMC 2010;24(7):737-43.
2010: Elizabeth J Want; Muireann Coen; Perrine Masson; Hector C Keun; Jake T M Pearce; Michael D Reily; Donald G Robertson; Cynthia M Rohde; Elaine Holmes; John C Lindon; Robert S Plumb; Jeremy K Nicholson
Ultra performance liquid chromatography-mass spectrometry profiling of bile acid metabolites in biofluids: application to experimental toxicology studies.
Analytical chemistry 2010;82(12):5282-9.
2010: Olaf Beckonert; Muireann Coen; Hector C Keun; Yulan Wang; Timothy M D Ebbels; Elaine Holmes; John C Lindon; Jeremy K Nicholson
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues.
Nature protocols 2010;5(6):1019-32.
2010: Elizabeth J Want; Ian D Wilson; Helen Gika; Georgios Theodoridis; Robert S Plumb; John P Shockcor; Elaine Holmes; Jeremy K Nicholson
Global metabolic profiling procedures for urine using UPLC-MS.
Nature protocols 2010;5(6):1005-18.
2010: Jasmina Saric; Jia V Li; Jonathan R Swann; Jürg Utzinger; Gail Calvert; Jeremy K Nicholson; Stephan Dirnhofer; Maggie J Dallman; Magda Bictash; Elaine Holmes
Integrated cytokine and metabolic analysis of pathological responses to parasite exposure in rodents.
Journal of proteome research 2010;9(5):2255-64.
2010: Judith M Fonville; Anthony D Maher; Muireann Coen; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Evaluation of full-resolution J-resolved 1H NMR projections of biofluids for metabonomics information retrieval and biomarker identification.
Analytical chemistry 2010;82(5):1811-21.
2010: Richard H Barton; Daniel Waterman; Frank W Bonner; Elaine Holmes; Robert Clarke; Jeremy K Nicholson; John C Lindon
The influence of EDTA and citrate anticoagulant addition to human plasma on information recovery from NMR-based metabolic profiling studies.
Molecular bioSystems 2010;6(1):215-24.
2010: Isabel Garcia Perez; A Couto Alves; S Angulo; J V Li; Jürg Utzinger; T M D Ebbels; Cristina Legido-Quigley; J K Nicholson; Elaine Holmes; Coral Barbas
Bidirectional correlation of NMR and capillary electrophoresis fingerprints: a new approach to investigating Schistosoma mansoni infection in a mouse model.
Analytical chemistry 2010;82(1):203-10.
2009: Cristina Legido-Quigley; Olivier Cloarec; David A Parker; Gerard M Murphy; Elaine Holmes; John C Lindon; Jeremy K Nicholson; Ragai R Mitry; Hector Vilca-Melendez; Mohamed Rela; Anil Dhawan; Nigel Heaton
First example of hepatocyte transplantation to alleviate ornithine transcarbamylase deficiency, monitored by NMR-based metabonomics.
Bioanalysis 2009;1(9):1527-35.
2009: Young-Shick Hong; Muireann Coen; Cynthia M Rhode; Michael D Reily; Donald G Robertson; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity.
Magnetic resonance in chemistry : MRC 2009;47 Suppl 1():S47-53.
2009: Eszter Bohus; Ákos Rácz; Béla Noszál; Muireann Coen; Olaf Beckonert; Hector C Keun; Timothy M D Ebbels; Glenn H Cantor; John A Wijsman; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat.
Magnetic resonance in chemistry : MRC 2009;47 Suppl 1():S26-35.
2009: Muireann Coen; Elizabeth J Want; T Andrew Clayton; Cynthia M Rhode; Young-Shick Hong; Hector C Keun; Glenn H Cantor; Alan L Metz; Donald G Robertson; Michael D Reily; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis.
Journal of proteome research 2009;8(11):5175-87.
2009: Caroline J Sands; Muireann Coen; Anthony D Maher; Timothy M D Ebbels; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Statistical total correlation spectroscopy editing of 1H NMR spectra of biofluids: application to drug metabolite profile identification and enhanced information recovery.
Analytical chemistry 2009;81(15):6458-66.
2009: Jasmina Saric; Jia V Li; Yulan Wang; Jennifer Keiser; Kirill Veselkov; Stephan Dirnhofer; Ivan K S Yap; Jeremy K Nicholson; Elaine Holmes; Jürg Utzinger
Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse.
Journal of proteome research 2009;8(8):3899-911.
2009: Francois-Pierre J Martin; Yulan Wang; Ivan K S Yap; Norbert Sprenger; John C Lindon; Francois-Pierre Martin; Sunil Kochhar; Elaine Holmes; Jeremy K Nicholson
Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity.
Journal of proteome research 2009;8(7):3464-74.
2009: Ruey Leng Loo; Muireann Coen; Timothy M D Ebbels; Olivier Cloarec; Elaine Maibaum; Magda Bictash; Ivan K S Yap; Paul Elliott; Jeremiah Stamler; Jeremy K Nicholson; Elaine Holmes
Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies.
Analytical chemistry 2009;81(13):5119-29.
2009: Tsz M Tsang; John N Haselden; Elaine Holmes
Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.
Neurochemical research 2009;34(7):1261-71.
2009: Leon M Smith; Anthony D Maher; Elizabeth J Want; Paul Elliott; Jeremiah Stamler; Geoffrey E Hawkes; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation.
Analytical chemistry 2009;81(12):4847-56.
2009: Alison Waldram; Elaine Holmes; Yulan Wang; Mattias Rantalainen; Ian D Wilson; Kieran Tuohy; Anne McCartney; Glenn R Gibson; Jeremy K Nicholson
Top-down systems biology modeling of host metabotype-microbiome associations in obese rodents.
Journal of proteome research 2009;8(5):2361-75.
2009: Gerard A McLoughlin; Dan Ma; Tsz M Tsang; Declan N C Jones; Jackie Cilia; Mark D Hill; Melanie J Robbins; Isabel M Benzel; Peter R Maycox; Elaine Holmes; Sabine Bahn
Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy.
Journal of proteome research 2009;8(4):1943-52.
2009: Jonathan Swann; Yulan Wang; Leticia Abecia; Adele Costabile; Kieran Tuohy; Glenn Gibson; David Roberts; James Sidaway; Huw Jones; Ian D Wilson; Jeremy Nicholson; Elaine Holmes
Gut microbiome modulates the toxicity of hydrazine: a metabonomic study.
Molecular bioSystems 2009;5(4):351-5.
2009: Francois-Pierre J Martin; norbert sprenger; Ivan K S Yap; Yulan Wang; Rodrigo Bibiloni; Florence Rochat; Francois-Pierre Martin; Christine Cherbut; Sunil Kochhar; John C Lindon; Elaine Holmes; Jeremy K Nicholson
Panorganismal gut microbiome-host metabolic crosstalk.
Journal of proteome research 2009;8(4):2090-105.
2009: Jia V Li; Elaine Holmes; Jasmina Saric; Jennifer Keiser; Stephan Dirnhofer; Jürg Utzinger; Yulan Wang
Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy.
International journal for parasitology 2009;39(5):547-58.
2009: Alexessander Couto Alves; Mattias Rantalainen; Elaine Holmes; Jeremy K Nicholson; Timothy M D Ebbels
Analytic properties of statistical total correlation spectroscopy based information recovery in 1H NMR metabolic data sets.
Analytical chemistry 2009;81(6):2075-84.
2009: Iola F Duarte; Cristina Legido-Quigley; David A Parker; Jonathan R Swann; Manfred Spraul; Ulrich Braumann; Ana M Gil; Elaine Holmes; Jeremy K Nicholson; Gerard M Murphy; Hector Vilca-Melendez; Nigel Heaton; John C Lindon
Identification of metabolites in human hepatic bile using 800 MHz 1H NMR spectroscopy, HPLC-NMR/MS and UPLC-MS.
Molecular bioSystems 2009;5(2):180-90.
2009: James Kinross; Alexander C von Roon; Nicholas Penney; Elaine Holmes; David Silk; Jeremy K Nicholson; Ara Darzi
The gut microbiota as a target for improved surgical outcome and improved patient care.
Current pharmaceutical design 2009;15(13):1537-45.
2009: Anthony D Maher; Olivier Cloarec; Prasad Patki; Michael Craggs; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Dynamic biochemical information recovery in spontaneous human seminal fluid reactions via 1H NMR kinetic statistical total correlation spectroscopy.
Analytical chemistry 2009;81(1):288-95.
2009: Kirill A Veselkov; John C Lindon; Timothy M D Ebbels; Derek J Crockford; Vladimir V Volynkin; Elaine Holmes; David B Davies; Jeremy K Nicholson
Recursive segment-wise peak alignment of biological (1)h NMR spectra for improved metabolic biomarker recovery.
Analytical chemistry 2009;81(1):56-66.
2008: Anthony D Maher; Prasad Patki; John C Lindon; Elizabeth J Want; Elaine Holmes; Michael Craggs; Jeremy K Nicholson
Seminal oligouridinosis: low uridine secretion as a biomarker for infertility in spinal neurotrauma.
Clinical chemistry 2008;54(12):2063-6.
2008: Anthony D Maher; Derek J Crockford; Henrik Toft; Daniel Malmodin; Johan Faber; Mark I McCarthy; Amy Barrett; Maxine Allen; Mark Walker; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Optimization of human plasma 1H NMR spectroscopic data processing for high-throughput metabolic phenotyping studies and detection of insulin resistance related to type 2 diabetes.
Analytical chemistry 2008;80(19):7354-62.
2008: Eszter Bohus; Muireann Coen; Hector C Keun; Timothy M D Ebbels; Olaf Beckonert; John C Lindon; Elaine Holmes; Béla Noszál; Jeremy K Nicholson
Temporal metabonomic modeling of l-arginine-induced exocrine pancreatitis.
Journal of proteome research 2008;7(10):4435-45.
2008: Elaine Holmes; Ian D Wilson; Jeremy K Nicholson
Metabolic phenotyping in health and disease.
Cell 2008;134(5):714-7.
2008: Ivan K S Yap; Jia V Li; Jasmina Saric; Francois-Pierre Martin; Huw Davies; Yulan Wang; Ian D Wilson; Jeremy K Nicholson; Jürg Utzinger; Julian R Marchesi; Elaine Holmes
Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse.
Journal of proteome research 2008;7(9):3718-28.
2008: Konstantina Papaspyridonos; Isabel Garcia Perez; Santiago Angulo; Paula J Domann; Hector Vilca-Melendez; Nigel Heaton; Gerard M Murphy; Elaine Holmes; Coral Barbas; Cristina Legido-Quigley
Fingerprinting of human bile during liver transplantation by capillary electrophoresis.
Journal of separation science 2008;31(16-17):3058-64.
2008: Jia V Li; Yulan Wang; Jasmina Saric; Jeremy K Nicholson; Stephan Dirnhofer; Burton H Singer; Marcel Tanner; Sergio Wittlin; Elaine Holmes; Jürg Utzinger
Global metabolic responses of NMRI mice to an experimental Plasmodium berghei infection.
Journal of proteome research 2008;7(9):3948-56.
2008: James M Kinross; Alexander C von Roon; Elaine Holmes; Ara Darzi; Jeremy K Nicholson
The human gut microbiome: implications for future health care.
Current gastroenterology reports 2008;10(4):396-403.
2008: Selena E Richards; Yulan Wang; Dennis Lawler; Sunil Kochhar; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Self-modeling curve resolution recovery of temporal metabolite signal modulation in NMR spectroscopic data sets: application to a life-long caloric restriction study in dogs.
Analytical chemistry 2008;80(13):4876-85.
2008: Elaine Holmes; Ruey Leng Loo; Jeremiah Stamler; Magda Bictash; Ivan K S Yap; Queenie Chan; Tim Ebbels; Maria De Iorio; Ian J Brown; Kirill A Veselkov; Martha L Daviglus; Hugo Kesteloot; Hirotsugu Ueshima; Liancheng Zhao; Jeremy K Nicholson; Paul Elliott
Human metabolic phenotype diversity and its association with diet and blood pressure.
Nature 2008;453(7193):396-400.
2008: Yulan Wang; Jürg Utzinger; Jasmina Saric; Jia V Li; Jean Burckhardt; Stephan Dirnhofer; Jeremy K Nicholson; Burton H Singer; Reto Brun; Elaine Holmes
Global metabolic responses of mice to Trypanosoma brucei brucei infection.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(16):6127-32.
2008: Richard H Barton; Jeremy K Nicholson; Paul Elliott; Elaine Holmes
High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study.
International journal of epidemiology 2008;37 Suppl 1():i31-40.
2008: Hector C Keun; Toby J Athersuch; Olaf Beckonert; Yulan Wang; Jasmina Saric; John P Shockcor; John C Lindon; Ian D Wilson; Elaine Holmes; Jeremy K Nicholson
Heteronuclear 19F-1H statistical total correlation spectroscopy as a tool in drug metabolism: study of flucloxacillin biotransformation.
Analytical chemistry 2008;80(4):1073-9.
2008: Yulan Wang; Olivier Cloarec; Huiru Tang; John C Lindon; Elaine Holmes; Sunil Kochhar; Jeremy K Nicholson
Magic angle spinning NMR and 1H-31P heteronuclear statistical total correlation spectroscopy of intact human gut biopsies.
Analytical chemistry 2008;80(4):1058-66.
2008: Min Li; Baohong Wang; Menghui Zhang; Mattias Rantalainen; Shengyue Wang; Haokui Zhou; Yan Zhang; Jian Shen; Xiaoyan Pang; Meiling Zhang; Hua Wei; Yu Chen; Haifeng Lu; Jian Zuo; Mingming Su; Qiu Yunping; Wei Jia; Chaoni Xiao; Leon M Smith; Shengli Yang; Elaine Holmes; Huiru Tang; Guoping Zhao; Jeremy K Nicholson; Lanjuan Li; Liping Zhao
Symbiotic gut microbes modulate human metabolic phenotypes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2117-22.
2008: Jung-Wook Bang; Derek J Crockford; Elaine Holmes; Florencio Pazos; Michael J E Sternberg; Stephen H Muggleton; Jeremy K Nicholson
Integrative top-down system metabolic modeling in experimental disease states via data-driven Bayesian methods.
Journal of proteome research 2008;7(2):497-503.
2008: Sandrine P Claus; Tsz M Tsang; Yulan Wang; Olivier Cloarec; Eleni Skordi; François-Pierre Martin; Francois-Pierre Martin; Alastair Ross; Sunil Kochhar; Elaine Holmes; Jeremy K Nicholson
Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.
Molecular systems biology 2008;4():219.
2008: Philipp Khaitovich; Helen E Lockstone; Matthew Wayland; Tsz M Tsang; Samantha D Jayatilaka; Arfu J Guo; Jie Zhou; Mehmet Somel; Laura W Harris; Elaine Holmes; Svante Pääbo; Sabine Bahn
Metabolic changes in schizophrenia and human brain evolution.
Genome biology 2008;9(8):R124.
2008: Francois-Pierre Martin; Yulan Wang; norbert sprenger; Ivan K S Yap; Serge Rezzi; Ziad Ramadan; Emma Peré-Trepat; Florence Rochat; Christine Cherbut; Peter van Bladeren; Laurent B Fay; Sunil Kochhar; John C Lindon; Elaine Holmes; Jeremy K Nicholson
Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model.
Molecular systems biology 2008;4():205.
2008: Jasmina Saric; Jia V Li; Yulan Wang; Jennifer Keiser; Jake G Bundy; Elaine Holmes; Jürg Utzinger
Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery.
PLoS neglected tropical diseases 2008;2(7):e254.
2008: Jane F Fearnside; Marc-Emmanuel Dumas; Alice R Rothwell; Steven P Wilder; Olivier Cloarec; Ayo TOYE; Christine Blancher; Elaine Holmes; Roger Tatoud; Richard H Barton; James Scott; Jeremy K Nicholson; Dominique Gauguier
Phylometabonomic patterns of adaptation to high fat diet feeding in inbred mice.
PloS one 2008;3(2):e1668.
2008: Max Bylesjö; Mattias Rantalainen; Jeremy K Nicholson; Elaine Holmes; Johan Trygg
K-OPLS package: kernel-based orthogonal projections to latent structures for prediction and interpretation in feature space.
BMC bioinformatics 2008;9():106.
2008: Mattias Rantalainen; Olivier Cloarec; Timothy M D Ebbels; Torbjörn Lundstedt; Jeremy K Nicholson; Elaine Holmes; Johan Trygg
Piecewise multivariate modelling of sequential metabolic profiling data.
BMC bioinformatics 2008;9():105.
2008: Francois-Pierre Martin; Yulan Wang; norbert sprenger; Ivan K S Yap; Torbjörn Lundstedt; Per Lek; Serge Rezzi; Ziad Ramadan; Peter van Bladeren; Laurent B Fay; Sunil Kochhar; John C Lindon; Elaine Holmes; Jeremy K Nicholson
Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model.
Molecular systems biology 2008;4():157.
2008: Muireann Coen; Elaine Holmes; John C Lindon; Jeremy K Nicholson
NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology.
Chemical research in toxicology 2008;21(1):9-27.
2008: Jasmina Saric; Yulan Wang; Jia Li; Muireann Coen; Jürg Utzinger; Julian R Marchesi; Jennifer Keiser; Kirill Veselkov; John C Lindon; Jeremy K Nicholson; Elaine Holmes
Species variation in the fecal metabolome gives insight into differential gastrointestinal function.
Journal of proteome research 2008;7(1):352-60.
2007: Muireann Coen; Young-Shick Hong; Olivier Cloarec; Cindy M Rhode; Michael D Reily; Donald G Robertson; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Heteronuclear 1H-31P statistical total correlation NMR spectroscopy of intact liver for metabolic biomarker assignment: application to galactosamine-induced hepatotoxicity.
Analytical chemistry 2007;79(23):8956-66.
2007: Eleni Skordi; Ivan K S Yap; Sandrine P Claus; Francois-Pierre Martin; Olivier Cloarec; Johan Lindberg; Ina Schuppe-Koistinen; Elaine Holmes; Jeremy K Nicholson
Analysis of time-related metabolic fluctuations induced by ethionine in the rat.
Journal of proteome research 2007;6(12):4572-81.
2007: Timothy M D Ebbels; Hector C Keun; Olaf Beckonert; Mary E Bollard; John C Lindon; Elaine Holmes; Jeremy K Nicholson
Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach.
Journal of proteome research 2007;6(11):4407-22.
2007: Jia Li; Yulan Wang; Alan Fenwick; T Andrew Clayton; Yu Y K Lau; Cristina Legido-Quigley; John C Lindon; Jürg Utzinger; Elaine Holmes
A high-performance liquid chromatography and nuclear magnetic resonance spectroscopy-based analysis of commercially available praziquantel tablets.
Journal of pharmaceutical and biomedical analysis 2007;45(2):263-7.
2007: Yulan Wang; Elaine Holmes; Elena M Comelli; Grigorios Fotopoulos; Gian Dorta; Huiru Tang; Mattias Rantalainen; John C Lindon; Irène Corthésy-Theulaz; Laurent B Fay; Sunil Kochhar; Jeremy K Nicholson
Topographical variation in metabolic signatures of human gastrointestinal biopsies revealed by high-resolution magic-angle spinning 1H NMR spectroscopy.
Journal of proteome research 2007;6(10):3944-51.
2007: Leon M Smith; Anthony D Maher; Olivier Cloarec; Mattias Rantalainen; Huiru Tang; Paul Elliott; Jeremiah Stamler; John C Lindon; Elaine Holmes; Jeremy K Nicholson
Statistical correlation and projection methods for improved information recovery from diffusion-edited NMR spectra of biological samples.
Analytical chemistry 2007;79(15):5682-9.
2007: Annalisa Vilasi; Pedro Cutillas; Anthony D Maher; Séverine Zirah; Giovambattista Capasso; Anthony W G Norden; Elaine Holmes; Jeremy K Nicholson; Robert J Unwin
Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome.
American journal of physiology. Renal physiology 2007;293(2):F456-67.
2007: Anthony D Maher; Séverine Zirah; Elaine Holmes; Jeremy K Nicholson
Experimental and analytical variation in human urine in 1H NMR spectroscopy-based metabolic phenotyping studies.
Analytical chemistry 2007;79(14):5204-11.
2007: Muireann Coen; Young-Shick Hong; T Andrew Clayton; C M Rohde; J T Pearce; Michael D Reily; Donald G Robertson; Elaine Holmes; John C Lindon; Jeremy K Nicholson
The mechanism of galactosamine toxicity revisited; a metabonomic study.
Journal of proteome research 2007;6(7):2711-9.
2007: Claire R Teague; Firdaus S Dhabhar; Richard H Barton; Bridgette M Beckwith-Hall; Jonathan Powell; Mark Cobain; Burton Singer; Bruce McEwen; John C Lindon; Jeremy K Nicholson; Elaine Holmes
Metabonomic studies on the physiological effects of acute and chronic psychological stress in Sprague-Dawley rats.
Journal of proteome research 2007;6(6):2080-93.
2007: Yulan Wang; Dennis Lawler; Brian Larson; Ziad Ramadan; Sunil Kochhar; Elaine Holmes; Jeremy K Nicholson
Metabonomic investigations of aging and caloric restriction in a life-long dog study.
Journal of proteome research 2007;6(5):1846-54.
2007: Elaine Holmes; Ruey Leng Loo; Olivier Cloarec; Muireann Coen; Huiru Tang; Elaine Maibaum; Stephen Bruce; Queenie Chan; Paul Elliott; Jeremiah Stamler; Ian D Wilson; John C Lindon; Jeremy K Nicholson
Detection of urinary drug metabolite (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.
Analytical chemistry 2007;79(7):2629-40.
2007: Francois-Pierre Martin; Yulan Wang; norbert sprenger; Elaine Holmes; John C Lindon; Sunil Kochhar; Jeremy K Nicholson
Effects of probiotic Lactobacillus paracasei treatment on the host gut tissue metabolic profiles probed via magic-angle-spinning NMR spectroscopy.
Journal of proteome research 2007;6(4):1471-81.
2007: John C Lindon; Elaine Holmes; Jeremy K Nicholson
Metabonomics in pharmaceutical R&D.
The FEBS journal 2007;274(5):1140-51.
2007: Johan Trygg; Elaine Holmes; Torbjörn Lundstedt
Chemometrics in metabonomics.
Journal of proteome research 2007;6(2):469-79.
2007: Elaine Holmes; Jeremy K Nicholson
Human metabolic phenotyping and metabolome wide association studies.
Ernst Schering Foundation symposium proceedings 2007;(4):227-49.
2007: Olaf Beckonert; Hector C Keun; Timothy M D Ebbels; Jacob G Bundy; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts.
Nature protocols 2007;2(11):2692-703.
2007: Jeffrey T-J Huang; F. Markus Leweke; Tsz M Tsang; Dagmar Koethe; Laura Kranaster; Christoph W Gerth; Sonja Gross; Daniela Schreiber; Stephan Ruhrmann; Frauke Schultze-Lutter; Joachim Klosterkötter; Elaine Holmes; Sabine Bahn
CSF metabolic and proteomic profiles in patients prodromal for psychosis.
PloS one 2007;2(8):e756.
2007: Francois-Pierre Martin; Marc-Emmanuel Dumas; Yulan Wang; Cristina Legido-Quigley; Ivan K S Yap; Huiru Tang; Séverine Zirah; Gerard M Murphy; Olivier Cloarec; John C Lindon; norbert sprenger; Laurent B Fay; Sunil Kochhar; Peter van Bladeren; Elaine Holmes; Jeremy K Nicholson
A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.
Molecular systems biology 2007;3():112.
2006: Cinzia Stella; Bridgette M Beckwith-Hall; Olivier Cloarec; Elaine Holmes; John C Lindon; Jonathan Powell; Frans van der Ouderaa; Sheila Bingham; Amanda J Cross; Jeremy K Nicholson
Susceptibility of human metabolic phenotypes to dietary modulation.
Journal of proteome research 2006;5(10):2780-8.
2006: Mattias Rantalainen; Olivier Cloarec; Olaf Beckonert; Ian D Wilson; David Jackson; Robert Tonge; Rachel Rowlinson; Steve Rayner; Janice Nickson; Robert W Wilkinson; Jonathan D Mills; Johan Trygg; Jeremy K Nicholson; Elaine Holmes
Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice.
Journal of proteome research 2006;5(10):2642-55.
2006: Francois-Pierre Martin; Elena F Verdu; Yulan Wang; Marc-Emmanuel Dumas; Ivan K S Yap; Olivier Cloarec; Gabriela E Bergonzelli; Irene Corthesy-Theulaz; Sunil Kochhar; Elaine Holmes; John C Lindon; Stephen Collins; Jeremy K Nicholson
Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation.
Journal of proteome research 2006;5(9):2185-93.
2006: Marc-Emmanuel Dumas; Richard H Barton; Ayo TOYE; Olivier Cloarec; Christine Blancher; Alice Rothwell; Jane F Fearnside; Roger Tatoud; Véronique Blanc; John C Lindon; Stephen C Mitchell; Elaine Holmes; Mark I McCarthy; James Scott; Dominique Gauguier; Jeremy K Nicholson
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(33):12511-6.
2006: Elaine Holmes; Tsz M Tsang; Jeffrey T-J Huang; F. Markus Leweke; Dagmar Koethe; Christoph W Gerth; Brit M Nolden; Sonja Gross; Daniela Schreiber; Jeremy K Nicholson; Sabine Bahn
Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia.
PLoS medicine 2006;3(8):e327.
2006: Elaine Holmes; Huiru Tang; Yulan Wang; Christoph Seger
The assessment of plant metabolite profiles by NMR-based methodologies.
Planta medica 2006;72(9):771-85.
2006: Andrew Craig; James Sidaway; Elaine Holmes; Terry Orton; David Jackson; Rachel Rowlinson; Janice Nickson; Robert Tonge; Ian Wilson; Jeremy Nicholson
Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.
Journal of proteome research 2006;5(7):1586-601.
2006: Yulan Wang; Elaine Holmes; Huiru Tang; John C Lindon; norbert sprenger; Marco E Turini; Gabriela E Bergonzelli; Laurent B Fay; Sunil Kochhar; Jeremy K Nicholson
Experimental metabonomic model of dietary variation and stress interactions.
Journal of proteome research 2006;5(7):1535-42.
2006: Elaine Holmes; Tsz M Tsang; Sarah J Tabrizi
The application of NMR-based metabonomics in neurological disorders.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2006;3(3):358-72.
2006: Derek J Crockford; John C Lindon; Olivier Cloarec; Robert S Plumb; Stephen J Bruce; Séverine Zirah; Paul David Rainville; Chris L Stumpf; Kelly Johnson; Elaine Holmes; Jeremy K Nicholson
Statistical search space reduction and two-dimensional data display approaches for UPLC-MS in biomarker discovery and pathway analysis.
Analytical chemistry 2006;78(13):4398-408.
2006: Orla Teahan; Simon C Gamble; Elaine Holmes; Jonathan Waxman; Jeremy K Nicholson; Charlotte L Bevan; Hector C Keun
Impact of analytical bias in metabonomic studies of human blood serum and plasma.
Analytical chemistry 2006;78(13):4307-18.
2006: Nigel J Waters; Catherine J Waterfield; R Duncan Farrant; Elaine Holmes; Jeremy K Nicholson
Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis.
Journal of proteome research 2006;5(6):1448-59.
2006: Elaine Holmes; Olivier Cloarec; Jeremy K Nicholson
Probing latent biomarker signatures and in vivo pathway activity in experimental disease states via statistical total correlation spectroscopy (STOCSY) of biofluids: application to HgCl2 toxicity.
Journal of proteome research 2006;5(6):1313-20.
2006: John C Lindon; Elaine Holmes; Jeremy K Nicholson
Metabonomics techniques and applications to pharmaceutical research & development.
Pharmaceutical research 2006;23(6):1075-88.
2006: Jeremy K Nicholson; Elaine Holmes
Global systems biology and personalized healthcare solutions.
Discovery medicine 2006;6(32):63-70.
2006: Tsz M Tsang; Jeffrey T-J Huang; Elaine Holmes; Sabine Bahn
Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients.
Journal of proteome research 2006;5(4):756-60.
2006: Andrew Craig; Olivier Cloarec; Elaine Holmes; Jeremy K Nicholson; John C Lindon
Scaling and normalization effects in NMR spectroscopic metabonomic data sets.
Analytical chemistry 2006;78(7):2262-7.
2006: Marc-Emmanuel Dumas; Elaine Maibaum; Claire Teague; Hirotsugu Ueshima; Beifan Zhou; John C Lindon; Jeremy K Nicholson; Jeremiah Stamler; Paul Elliott; Queenie Chan; Elaine Holmes
Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study.
Analytical chemistry 2006;78(7):2199-208.
2006: Tsz M Tsang; Ben Woodman; Gerard A McLoughlin; Julian L Griffin; Sarah J Tabrizi; Gillian P Bates; Elaine Holmes
Metabolic characterization of the R6/2 transgenic mouse model of Huntington's disease by high-resolution MAS 1H NMR spectroscopy.
Journal of proteome research 2006;5(3):483-92.
2006: Yulan Wang; Jürg Utzinger; Shu-Hua Xiao; Jian Xue; Jeremy K Nicholson; Marcel Tanner; Burton H Singer; Elaine Holmes
System level metabolic effects of a Schistosoma japonicum infection in the Syrian hamster.
Molecular and biochemical parasitology 2006;146(1):1-9.
2006: Yulan Wang; Mary E Bollard; Jeremy K Nicholson; Elaine Holmes
Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague-Dawley rats using high-resolution magic angle spinning 1H NMR spectroscopy of intact tissue and pattern recognition.
Journal of pharmaceutical and biomedical analysis 2006;40(2):375-81.
2006: Derek J Crockford; Elaine Holmes; John C Lindon; Robert S Plumb; Séverine Zirah; Stephen J Bruce; Paul David Rainville; Chris L Stumpf; Jeremy K Nicholson
Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: application in metabonomic toxicology studies.
Analytical chemistry 2006;78(2):363-71.
2005: Jahanara Azmi; John Connelly; Elaine Holmes; Jeremy K Nicholson; Richard F Shore; Julian L Griffin
Characterization of the biochemical effects of 1-nitronaphthalene in rats using global metabolic profiling by NMR spectroscopy and pattern recognition.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2005;10(6):401-16.
2005: John C Lindon; Hector C Keun; Timothy M D Ebbels; Jake Mt Pearce; Elaine Holmes; Jeremy K Nicholson
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements.
Pharmacogenomics 2005;6(7):691-9.
2005: Elaine Holmes; Jeremy Nicholson
Variation in gut microbiota strongly influences individual rodent phenotypes.
Toxicological sciences : an official journal of the Society of Toxicology 2005;87(1):1-2.
2005: Elizabeth G Stanley; Nigel J C Bailey; Mary E Bollard; John N Haselden; Catherine J Waterfield; Elaine Holmes; Jeremy K Nicholson
Sexual dimorphism in urinary metabolite profiles of Han Wistar rats revealed by nuclear-magnetic-resonance-based metabonomics.
Analytical biochemistry 2005;343(2):195-202.
2005: Jahanara Azmi; Julian L Griffin; Richard F Shore; Elaine Holmes; Jeremy K Nicholson
Chemometric analysis of biofluids following toxicant induced hepatotoxicity: a metabonomic approach to distinguish the effects of 1-naphthylisothiocyanate from its products.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(8):839-52.
2005: Derek J Crockford; Hector C Keun; L M Smith; Elaine Holmes; Jeremy K Nicholson
Curve-fitting method for direct quantitation of compounds in complex biological mixtures using 1H NMR: application in metabonomic toxicology studies.
Analytical chemistry 2005;77(14):4556-62.
2005: Yulan Wang; Huiru Tang; Elaine Holmes; John C Lindon; Marco E Turini; norbert sprenger; Gabriela E Bergonzelli; Laurent B Fay; Sunil Kochhar; Jeremy K Nicholson
Biochemical characterization of rat intestine development using high-resolution magic-angle-spinning 1H NMR spectroscopy and multivariate data analysis.
Journal of proteome research 2005;4(4):1324-9.
2005: Pär Jonsson; Stephen J Bruce; Thomas Moritz; Johan Trygg; Michael Sjöström; Robert S Plumb; Jennifer Granger; Elaine Maibaum; Jeremy K Nicholson; Elaine Holmes; Henrik Antti
Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets.
The Analyst 2005;130(5):701-7.
2005: Tsz M Tsang; Julian L Griffin; John N Haselden; C Fish; Elaine Holmes
Metabolic characterization of distinct neuroanatomical regions in rats by magic angle spinning 1H nuclear magnetic resonance spectroscopy.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2005;53(5):1018-24.
2005: Jeremy K Nicholson; Elaine Holmes; Ian D Wilson
Gut microorganisms, mammalian metabolism and personalized health care.
Nature reviews. Microbiology 2005;3(5):431-8.
2005: Mary E Bollard; Elizabeth G Stanley; John C Lindon; Jeremy K Nicholson; Elaine Holmes
NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition.
NMR in biomedicine 2005;18(3):143-62.
2005: Mary E Bollard; Hector C Keun; Olaf Beckonert; Timothy M D Ebbels; Henrik Antti; Andrew Nicholls; John P Shockcor; Glenn H Cantor; Greg Stevens; John C Lindon; Elaine Holmes; Jeremy K Nicholson
Comparative metabonomics of differential hydrazine toxicity in the rat and mouse.
Toxicology and applied pharmacology 2005;204(2):135-51.
2005: Nigel J Waters; Catherine J Waterfield; R Duncan Farrant; Elaine Holmes; Jeremy K Nicholson
Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity.
Chemical research in toxicology 2005;18(4):639-54.
2005: Kirty S Solanky; Nigel J C Bailey; Bridgette M Beckwith-Hall; Sheila Bingham; Adrienne Davis; Elaine Holmes; Jeremy K Nicholson; Aedin Cassidy
Biofluid 1H NMR-based metabonomic techniques in nutrition research - metabolic effects of dietary isoflavones in humans.
The Journal of nutritional biochemistry 2005;16(4):236-44.
2005: Olivier Cloarec; Marc-Emmanuel Dumas; Andrew Craig; Richard H Barton; Johan Trygg; Jane Hudson; Christine Blancher; Dominique Gauguier; John C Lindon; Elaine Holmes; Jeremy Nicholson
Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.
Analytical chemistry 2005;77(5):1282-9.
2005: Sarah Garrod; Mary E Bollard; Andrew Nicholls; Susan C Connor; John Connelly; Jeremy K Nicholson; Elaine Holmes
Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat.
Chemical research in toxicology 2005;18(2):115-22.
2005: Yulan Wang; Huiru Tang; Jeremy K Nicholson; Peter J Hylands; Julia Sampson; Elaine Holmes
A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion.
Journal of agricultural and food chemistry 2005;53(2):191-6.
2005: Olivier Cloarec; Marc-Emmanuel Dumas; Johan Trygg; Andrew Craig; Richard H Barton; John C Lindon; Jeremy K Nicholson; Elaine Holmes
Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies.
Analytical chemistry 2005;77(2):517-26.
2004: Timothy M D Ebbels; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Evaluation of metabolic variation in normal rat strains from a statistical analysis of 1H NMR spectra of urine.
Journal of pharmaceutical and biomedical analysis 2004;36(4):823-33.
2004: Jeremy K Nicholson; Elaine Holmes; John C Lindon; Ian D Wilson
The challenges of modeling mammalian biocomplexity.
Nature biotechnology 2004;22(10):1268-74.
2004: Lennart Eriksson; Henrik Antti; Johan Gottfries; Elaine Holmes; Erik Johansson; Fredrik Lindgren; Ingrid Long; Torbjörn Lundstedt; Johan Trygg; Svante Wold
Using chemometrics for navigating in the large data sets of genomics, proteomics, and metabonomics (gpm).
Analytical and bioanalytical chemistry 2004;380(3):419-29.
2004: Yulan Wang; Elaine Holmes; Jeremy K Nicholson; Olivier Cloarec; Jacques Chollet; Marcel Tanner; Burton H Singer; Jürg Utzinger
Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12676-81.
2004: John C Lindon; Elaine Holmes; Jeremy K Nicholson
Metabonomics: systems biology in pharmaceutical research and development.
Current opinion in molecular therapeutics 2004;6(3):265-72.
2004: Hector C Keun; Timothy M D Ebbels; Mary E Bollard; Olaf Beckonert; Henrik Antti; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Geometric trajectory analysis of metabolic responses to toxicity can define treatment specific profiles.
Chemical research in toxicology 2004;17(5):579-87.
2004: Nigel J C Bailey; Yulan Wang; Julia Sampson; Wendy Davis; Ian Whitcombe; Peter J Hylands; Simon L Croft; Elaine Holmes
Prediction of anti-plasmodial activity of Artemisia annua extracts: application of 1H NMR spectroscopy and chemometrics.
Journal of pharmaceutical and biomedical analysis 2004;35(1):117-26.
2004: Yulan Wang; Huiru Tang; Jeremy K Nicholson; Peter J Hylands; Julia Sampson; Ian Whitcombe; Christopher G Stewart; Steve Caiger; Isaac Oru; Elaine Holmes
Metabolomic strategy for the classification and quality control of phytomedicine: a case study of chamomile flower (Matricaria recutita L.).
Planta medica 2004;70(3):250-5.
2004: John C Lindon; Elaine Holmes; Jeremy K Nicholson
Metabonomics and its role in drug development and disease diagnosis.
Expert review of molecular diagnostics 2004;4(2):189-99.
2004: Claire Teague; Elaine Holmes; Elaine Maibaum; Jeremy Nicholson; Huiru Tang; Queenie Chan; Paul Elliott; Jeremiah Stamler; Hirotsugu Ueshima; Beifan Zhou; Ian Wilson
Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans.
The Analyst 2004;129(3):259-64.
2004: John C Lindon; Elaine Holmes; Mary E Bollard; Elizabeth G Stanley; Jeremy K Nicholson
Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2004;9(1):1-31.
2003: Kirty S Solanky; Nigel J C Bailey; Bridgette M Beckwith-Hall; Adrienne Davis; Sheila Bingham; Elaine Holmes; Jeremy K Nicholson; Aedin Cassidy
Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profile.
Analytical biochemistry 2003;323(2):197-204.
2003: Yulan Wang; Mary E Bollard; Hector C Keun; Henrik Antti; Olaf Beckonert; Timothy M D Ebbels; John C Lindon; Elaine Holmes; Huiru Tang; Jeremy K Nicholson
Spectral editing and pattern recognition methods applied to high-resolution magic-angle spinning 1H nuclear magnetic resonance spectroscopy of liver tissues.
Analytical biochemistry 2003;323(1):26-32.
2003: John C Lindon; Elaine Holmes; Jeremy K Nicholson
So what's the deal with metabonomics?
Analytical chemistry 2003;75(17):384A-391A.
2003: Kirty S Solanky; Nigel J C Bailey; Elaine Holmes; John C Lindon; Adrienne L Davis; Theo P J Mulder; John P M van Duynhoven; Jeremy K Nicholson
NMR-based metabonomic studies on the biochemical effects of epicatechin in the rat.
Journal of agricultural and food chemistry 2003;51(14):4139-45.
2003: Bridgette M Beckwith-Hall; Nicholas A Thompson; Jeremy K Nicholson; John C Lindon; Elaine Holmes
A metabonomic investigation of hepatotoxicity using diffusion-edited 1H NMR spectroscopy of blood serum.
The Analyst 2003;128(7):814-8.
2003: John C Lindon; Jeremy K Nicholson; Elaine Holmes; Henrik Antti; Mary E Bollard; Hector C Keun; Olaf Beckonert; Timothy M D Ebbels; Michael D Reily; Donald Robertson; Gregory J Stevens; Peter Luke; Alan P Breau; Glenn H Cantor; Roy H Bible; Urs Niederhauser; Hans Senn; Götz Schlotterbeck; Ulla G Sidelmann; Steen M Laursen; Adrienne A Tymiak; Bruce D Car; Lois D Lehman-McKeeman; Jean Marie Colet; Ali Loukaci; Craig Thomas
Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project.
Toxicology and applied pharmacology 2003;187(3):137-46.
2003: Nigel J C Bailey; Matjaz Oven; Elaine Holmes; Jeremy K Nicholson; Meinhart H Zenk
Metabolomic analysis of the consequences of cadmium exposure in Silene cucubalus cell cultures via 1H NMR spectroscopy and chemometrics.
Phytochemistry 2003;62(6):851-8.
2003: Joanne T Brindle; Jeremy K Nicholson; Peter M Schofield; David J Grainger; Elaine Holmes
Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension.
The Analyst 2003;128(1):32-6.
2002: Elaine Holmes; Henrik Antti
Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra.
The Analyst 2002;127(12):1549-57.
2002: Joanne T Brindle; Henrik Antti; Elaine Holmes; George Tranter; Jeremy K Nicholson; Hugh W L Bethell; Sarah Clarke; Peter M Schofield; Elaine McKilligin; David Mosedale; David J Grainger
Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics.
Nature medicine 2002;8(12):1439-44.
2002: John C Connelly; Susan C Connor; Soria Monte; Nigel J C Bailey; Nathan Borgeaud; Elaine Holmes; Jeff Troke; Jeremy K Nicholson; Claire Gavaghan
Application of directly coupled high performance liquid chromatography-NMR-mass spectometry and 1H NMR spectroscopic studies to the investigation of 2,3-benzofuran metabolism in Sprague-Dawley rats.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(12):1357-63.
2002: Hector C Keun; Timothy M D Ebbels; Henrik Antti; Mary E Bollard; Olaf Beckonert; Götz Schlotterbeck; Hans Senn; Urs Niederhauser; Elaine Holmes; John C Lindon; Jeremy K Nicholson
Analytical reproducibility in (1)H NMR-based metabonomic urinalysis.
Chemical research in toxicology 2002;15(11):1380-6.
2002: Mary E Bollard; Jinsheng Xu; Wendy Purcell; Julian L Griffin; Christopher Quirk; Elaine Holmes; Jeremy K Nicholson
Metabolic profiling of the effects of D-galactosamine in liver spheroids using (1)H NMR and MAS-NMR spectroscopy.
Chemical research in toxicology 2002;15(11):1351-9.
2002: Bridgette M Beckwith-Hall; Joanne T Brindle; Richard H Barton; Muireann Coen; Elaine Holmes; Jeremy K Nicholson; Henrik Antti
Application of orthogonal signal correction to minimise the effects of physical and biological variation in high resolution 1H NMR spectra of biofluids.
The Analyst 2002;127(10):1283-8.
2002: Steve Mitchell; Elaine Holmes; Carmichael Paul
Metabonomics and medicine: the Biochemical Oracle.
Biologist (London, England) 2002;49(5):217-21.
2002: Bridgette M Beckwith-Hall; Elaine Holmes; John C Lindon; John Gounarides; Alison Vickers; michael shapiro; Jeremy K Nicholson
NMR-based metabonomic studies on the biochemical effects of commonly used drug carrier vehicles in the rat.
Chemical research in toxicology 2002;15(9):1136-41.
2002: Nigel J C Bailey; Julia Sampson; Peter J Hylands; Jeremy K Nicholson; Elaine Holmes
Multi-component metabolic classification of commercial feverfew preparations via high-field 1H-NMR spectroscopy and chemometrics.
Planta medica 2002;68(8):734-8.
2002: Nigel J Waters; Elaine Holmes; Catherine J Waterfield; R Duncan Farrant; Jeremy K Nicholson
NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate.
Biochemical pharmacology 2002;64(1):67-77.
2002: Graeme Scarfe; Ian D Wilson; MA Warne; Elaine Holmes; Jeremy K Nicholson; John C Lindon
Structure-metabolism relationships of substituted anilines: prediction of N-acetylation and N-oxanilic acid formation using computational chemistry.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(4):267-77.
2002: Jeremy K Nicholson; John Connelly; John C Lindon; Elaine Holmes
Metabonomics: a platform for studying drug toxicity and gene function.
Nature reviews. Drug discovery 2002;1(2):153-61.
2002: Jahanara Azmi; Julian L Griffin; Henrik Antti; Richard F Shore; Erik Johansson; Jeremy K Nicholson; Elaine Holmes
Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data.
The Analyst 2002;127(2):271-6.
2002: Ann M Talbert; George E Tranter; Elaine Holmes; Peter L Francis
Determination of drug-plasma protein binding kinetics and equilibria by chromatographic profiling: exemplification of the method using L-tryptophan and albumin.
Analytical chemistry 2002;74(2):446-52.
2002: John P Shockcor; Elaine Holmes
Metabonomic applications in toxicity screening and disease diagnosis.
Current topics in medicinal chemistry 2002;2(1):35-51.
2001: Nigel J Waters; Elaine Holmes; A Williams; Catherine J Waterfield; R Duncan Farrant; Jeremy K Nicholson
NMR and pattern recognition studies on the time-related metabolic effects of alpha-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach.
Chemical research in toxicology 2001;14(10):1401-12.
2001: Mary E Bollard; Elaine Holmes; John C Lindon; Stephen C Mitchell; D Branstetter; W Zhang; Jeremy K Nicholson
Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition.
Analytical biochemistry 2001;295(2):194-202.
2001: Andrew Nicholls; Elaine Holmes; John C Lindon; John P Shockcor; R Duncan Farrant; John N Haselden; SJ Damment; Catherine J Waterfield; Jeremy K Nicholson
Metabonomic investigations into hydrazine toxicity in the rat.
Chemical research in toxicology 2001;14(8):975-87.
2001: Muireann Coen; John C Lindon; Claire Gavaghan; Elaine Holmes; Eberhard Humpfer; Ian D Wilson; PD Stanley; Jeremy K Nicholson
Investigation of water environments in a C18 bonded silica phase using 1H magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy.
The Analyst 2001;126(5):548-50.
2001: Sarah Garrod; E Humpher; Susan C Connor; John C Connelly; Manfred Spraul; Jeremy K Nicholson; Elaine Holmes
High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2001;45(5):781-90.
2001: Claire Gavaghan; Jeremy K Nicholson; Susan C Connor; Ian D Wilson; B Wright; Elaine Holmes
Directly coupled high-performance liquid chromatography and nuclear magnetic resonance spectroscopic with chemometric studies on metabolic variation in Sprague--Dawley rats.
Analytical biochemistry 2001;291(2):245-52.
2001: Elaine Holmes; Jeremy K Nicholson; George E Tranter
Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks.
Chemical research in toxicology 2001;14(2):182-91.
2000: Julian L Griffin; LA Walker; Sarah Garrod; Elaine Holmes; Richard F Shore; Jeremy K Nicholson
NMR spectroscopy based metabonomic studies on the comparative biochemistry of the kidney and urine of the bank vole (Clethrionomys glareolus), wood mouse (Apodemus sylvaticus), white toothed shrew (Crocidura suaveolens) and the laboratory rat.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2000;127(3):357-67.
2000: Mary E Bollard; Sarah Garrod; Elaine Holmes; John C Lindon; Eberhard Humpfer; Manfred Spraul; Jeremy K Nicholson
High-resolution (1)H and (1)H-(13)C magic angle spinning NMR spectroscopy of rat liver.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;44(2):201-7.
2000: Nigel J Waters; Sarah Garrod; R Duncan Farrant; John N Haselden; Susan C Connor; John Connelly; John C Lindon; Elaine Holmes; Jeremy K Nicholson
High-resolution magic angle spinning (1)H NMR spectroscopy of intact liver and kidney: optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition.
Analytical biochemistry 2000;282(1):16-23.
2000: Elaine Holmes; Andrew Nicholls; John C Lindon; Susan C Connor; John C Connelly; John N Haselden; SJ Damment; Manfred Spraul; P Neidig; Jeremy K Nicholson
Chemometric models for toxicity classification based on NMR spectra of biofluids.
Chemical research in toxicology 2000;13(6):471-8.
2000: anne Rosemary Tate; Peta J D Foxall; Elaine Holmes; Detlef Moka; Manfred Spraul; Jeremy K Nicholson; John C Lindon
Distinction between normal and renal cell carcinoma kidney cortical biopsy samples using pattern recognition of (1)H magic angle spinning (MAS) NMR spectra.
NMR in biomedicine 2000;13(2):64-71.
2000: Elaine Holmes; John P Shockcor
Accelerated toxicity screening using NMR and pattern recognition-based methods.
Current opinion in drug discovery & development 2000;3(1):72-8.
1999: Jeremy K Nicholson; John C Lindon; Elaine Holmes
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(11):1181-9.
1999: Sarah Garrod; Eberhard Humpfer; Manfred Spraul; Susan C Connor; S Polley; John Connelly; John C Lindon; Jeremy K Nicholson; Elaine Holmes
High-resolution magic angle spinning 1H NMR spectroscopic studies on intact rat renal cortex and medulla.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1999;41(6):1108-18.
1999: B C Cupid; Elaine Holmes; Ian D Wilson; John C Lindon; Jeremy K Nicholson
Quantitative structure-metabolism relationships (QSMR) using computational chemistry: pattern recognition analysis and statistical prediction of phase II conjugation reactions of substituted benzoic acids in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(1):27-42.
1998: Elaine Holmes; Andrew Nicholls; John C Lindon; S Ramos; Manfred Spraul; P Neidig; Susan C Connor; John Connelly; SJ Damment; John N Haselden; Jeremy K Nicholson
Development of a model for classification of toxin-induced lesions using 1H NMR spectroscopy of urine combined with pattern recognition.
NMR in biomedicine 1998;11(4-5):235-44.
1998: B M Beckwith-Hall; Jeremy K Nicholson; Andrew Nicholls; Peta J D Foxall; John C Lindon; Susan C Connor; M Abdi; John Connelly; Elaine Holmes
Nuclear magnetic resonance spectroscopic and principal components analysis investigations into biochemical effects of three model hepatotoxins.
Chemical research in toxicology 1998;11(4):260-72.
1997: Elaine Holmes; Peta J D Foxall; Manfred Spraul; R Duncan Farrant; Jeremy K Nicholson; John C Lindon
750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease.
Journal of pharmaceutical and biomedical analysis 1997;15(11):1647-59.
1997: Elaine Holmes; F W Bonner; Jeremy K Nicholson
1H NMR spectroscopic and histopathological studies on propyleneimine-induced renal papillary necrosis in the rat and the multimammate desert mouse (Mastomys natalensis).
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1997;116(2):125-34.
1996: Elaine Holmes; F W Bonner; Jeremy K Nicholson
Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the multimammate mouse (Mastomys natalensis).
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology 1996;114(1):7-15.
1996: M E Bollard; Elaine Holmes; C A Blackledge; John C Lindon; Ian D Wilson; Jeremy K Nicholson
1H and 19F-nmr spectroscopic studies on the metabolism and urinary excretion of mono- and disubstituted phenols in the rat.
Xenobiotica; the fate of foreign compounds in biological systems 1996;26(3):255-73.
1995: Elaine Holmes; B C Sweatman; M E Bollard; C A Blackledge; C R Beddell; Ian D Wilson; John C Lindon; Jeremy K Nicholson
Prediction of urinary sulphate and glucuronide conjugate excretion for substituted phenols in the rat using quantitative structure-metabolism relationships.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(12):1269-81.
1995: M L Anthony; Elaine Holmes; P C McDowell; T J Gray; M Blackmore; Jeremy K Nicholson
1H NMR spectroscopic studies on the reactions of haloalkylamines with bicarbonate ions: formation of N-carbamates and 2-oxazolidones in cell culture media and blood plasma.
Chemical research in toxicology 1995;8(8):1046-53.
1995: Elaine Holmes; S Caddick; John C Lindon; Ian D Wilson; S Kryvawych; Jeremy K Nicholson
1H and 2H NMR spectroscopic studies on the metabolism and biochemical effects of 2-bromoethanamine in the rat.
Biochemical pharmacology 1995;49(10):1349-59.
1995: Elaine Holmes; F W Bonner; Jeremy K Nicholson
Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis).
Archives of toxicology 1995;70(2):89-95.
1994: Manfred Spraul; P Neidig; U Klauck; P Kessler; Elaine Holmes; Jeremy K Nicholson; B C Sweatman; S R Salman; R Duncan Farrant; E Rahr
Automatic reduction of NMR spectroscopic data for statistical and pattern recognition classification of samples.
Journal of pharmaceutical and biomedical analysis 1994;12(10):1215-25.
1994: Elaine Holmes; P J Foxall; Jeremy K Nicholson; Guy H Neild; S M Brown; C R Beddell; B C Sweatman; E Rahr; John C Lindon; Manfred Spraul
Automatic data reduction and pattern recognition methods for analysis of 1H nuclear magnetic resonance spectra of human urine from normal and pathological states.
Analytical biochemistry 1994;220(2):284-96.
1993: B C Sweatman; R Duncan Farrant; Elaine Holmes; F Y Ghauri; Jeremy K Nicholson; John C Lindon
600 MHz 1H-NMR spectroscopy of human cerebrospinal fluid: effects of sample manipulation and assignment of resonances.
Journal of pharmaceutical and biomedical analysis 1993;11(8):651-64.
1992: Elaine Holmes; Jeremy K Nicholson; F W Bonner; B C Sweatman; C R Beddell; John C Lindon; E Rahr
Mapping the biochemical trajectory of nephrotoxicity by pattern recognition of NMR urinanalysis.
NMR in biomedicine 1992;5(6):368-72.
1992: Elaine Holmes; F W Bonner; B C Sweatman; John C Lindon; C R Beddell; E Rahr; Jeremy K Nicholson
Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine.
Molecular pharmacology 1992;42(5):922-30.
1990: Elaine Holmes; P J Foxall; Jeremy K Nicholson
Proton NMR analysis of plasma from renal failure patients: evaluation of sample preparation and spectral-editing methods.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):955-8.
1990: Elaine Holmes; F W Bonner; K P Gartland; Jeremy K Nicholson
Proton NMR monitoring of the onset and recovery of experimental renal damage.
Journal of pharmaceutical and biomedical analysis 1990;8(8-12):959-62.