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Eric Holmes

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Susan Shetterly; Franziska Cohen; Susan R Watson; Ronald M A Knegtel; Bruce A Macher; Eric H Holmes
Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain.
Anne L Sherwood; David A Upchurch; Mark R Stroud; William C Davis; Eric H Holmes
A highly conserved His-His motif present in alpha1-->3/4fucosyltransferases is required for optimal activity and functions in acceptor binding.
Theodora De Vries; Ronald M A Knegtel; Eric H Holmes; Bruce A Macher
Fucosyltransferases: structure/function studies.

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All Publications

2007: Susan Shetterly; Franziska Cohen; Susan R Watson; Ronald M A Knegtel; Bruce A Macher; Eric H Holmes
Site-specific fucosylation of sialylated polylactosamines by alpha1,3/4-fucosyltransferases-V and -VI Is defined by amino acids near the N terminus of the catalytic domain.
The Journal of biological chemistry 2007;282(34):24882-92.
2002: Anne L Sherwood; David A Upchurch; Mark R Stroud; William C Davis; Eric H Holmes
A highly conserved His-His motif present in alpha1-->3/4fucosyltransferases is required for optimal activity and functions in acceptor binding.
Glycobiology 2002;12(10):599-606.
2001: Theodora De Vries; Ronald M A Knegtel; Eric H Holmes; Bruce A Macher
Fucosyltransferases: structure/function studies.
Glycobiology 2001;11(10):119R-128R.
2001: Anne L Sherwood; Mark R Stroud; Steven B Levery; Eric H Holmes
An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures.
Biochemistry 2001;40(19):5708-19.
2000: Eric H Holmes; Ten-Yang Yen; S Thomas; R Joshi; A Nguyen; T Long; F Gallet; Abderrahman Maftah; Raymond Julien; Bruce A Macher
Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites.
The Journal of biological chemistry 2000;275(32):24237-45.
2000: Anne L Sherwood; W C Davis; S Ho; Bruce A Macher; Mark R Stroud; D A Upchurch; Eric H Holmes
A GDP-fucose-protected, pyridoxal-5'-Phosphate/NaBH(4)-sensitive lys residue common to human alpha1-->3Fucosyltransferases corresponds to Lys(300) in FucT-IV.
Biochemical and biophysical research communications 2000;273(3):870-6.
2000: WT Tino; M J Huber; T P Lake; TG Greene; GP Murphy; Eric H Holmes
Isolation and characterization of monoclonal antibodies specific for protein conformational epitopes present in prostate-specific membrane antigen (PSMA).
Hybridoma 2000;19(3):249-57.
2000: Jiankun Cui; Eric H Holmes; TG Greene; Philip K Liu
Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(7):955-67.
2000: SL Su; AL Boynton; Eric H Holmes; AA Elgamal; GP Murphy
Detection of extraprostatic prostate cells utilizing reverse transcription-polymerase chain reaction.
Seminars in surgical oncology 2000;18(1):17-28.
2000: AA Elgamal; Eric H Holmes; SL Su; WT Tino; SJ Simmons; M Peterson; TG Greene; AL Boynton; GP Murphy
Prostate-specific membrane antigen (PSMA): current benefits and future value.
Seminars in surgical oncology 2000;18(1):10-6.
1999: Jiankun Cui; Eric H Holmes; Philip K Liu
Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia.
Journal of neurochemistry 1999;73(3):1164-74.
1999: Anne L Sherwood; Eric H Holmes
Analysis of the expression and enzymatic properties of alpha1-->3fucosyltransferase from human lung carcinoma NCI-H69 and PC9 cells.
Glycobiology 1999;9(7):637-43.
1998: GP Murphy; AA Elgamal; SL Su; D G Bostwick; Eric H Holmes
Current evaluation of the tissue localization and diagnostic utility of prostate specific membrane antigen.
Cancer 1998;83(11):2259-69.
1998: GP Murphy; TG Greene; WT Tino; AL Boynton; Eric H Holmes
Isolation and characterization of monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen.
The Journal of urology 1998;160(6 Pt 2):2396-401.
1998: Tilo Schwientek; Raquel Almeida; Steven B Levery; Eric H Holmes; E Bennett; Henrik Clausen
Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis.
The Journal of biological chemistry 1998;273(45):29331-40.
1998: Anne L Sherwood; A T Nguyen; J M Whitaker; Bruce A Macher; Mark R Stroud; Eric H Holmes
Human alpha1,3/4-fucosyltransferases. III. A Lys/Arg residue located within the alpha1,3-FucT motif is required for activity but not substrate binding.
The Journal of biological chemistry 1998;273(39):25256-60.
1998: Loc H Vo; S Lee; M C Marcinko; Eric H Holmes; Bruce A Macher
Human alpha1,3/4-fucosyltransferases. II. A single amino acid at the COOH terminus of FucT III and V alters their kinetic properties.
The Journal of biological chemistry 1998;273(39):25250-5.
1998: A T Nguyen; Eric H Holmes; J M Whitaker; S Ho; Susan Shetterly; Bruce A Macher
Human alpha1,3/4-fucosyltransferases. I. Identification of amino acids involved in acceptor substrate binding by site-directed mutagenesis.
The Journal of biological chemistry 1998;273(39):25244-9.
1998: RJ Barren; Eric H Holmes; AL Boynton; AK Gregorakis; AA Elgamal; Oliver E Cobb; C L Wilson; Haakon Ragde; GP Murphy
Method for identifying prostate cells in semen using flow cytometry.
The Prostate 1998;36(3):181-8.
1998: Anne L Sherwood; Eric H Holmes
Cloning and expression of the catalytic domain from rat hepatoma H35 cell GDP-fucose:GM1 alpha 1-->2fucosyltransferase, an enzyme which is activated during early stages of chemical carcinogenesis in rat liver.
Archives of biochemistry and biophysics 1998;355(2):215-21.
1998: Margarida Amado; Raquel Almeida; Fátima Carneiro; Steven B Levery; Eric H Holmes; M Nomoto; Michael A Hollingsworth; Helle Hassan; Tilo Schwientek; PA Nielsen; Eric P Bennett; Henrik Clausen
A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.
The Journal of biological chemistry 1998;273(21):12770-8.
1998: GP Murphy; GM Kenny; Haakon Ragde; R L Wolfert; AL Boynton; Eric H Holmes; S L Misrock; Georg Bartsch; Helmut Klocker; J Pointner; A Reissigl; D G McLeod; T Douglas; T Morgan; J Gilbaugh
Measurement of serum prostate-specific membrane antigen, a new prognostic marker for prostate cancer.
Urology 1998;51(5A Suppl):89-97.
1998: AK Gregorakis; Eric H Holmes; GP Murphy
Prostate-specific membrane antigen: current and future utility.
Seminars in urologic oncology 1998;16(1):2-12.
1997: Raquel Almeida; Margarida Amado; Leonor David; Steven B Levery; Eric H Holmes; Gerard F M Merkx; AG van Kessel; E Rygaard; Helle Hassan; E Bennett; Henrik Clausen
A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.
The Journal of biological chemistry 1997;272(51):31979-91.
1997: GP Murphy; R T Maguire; B Rogers; Alan W Partin; W B Nelp; MJ Troychak; Haakon Ragde; GM Kenny; RJ Barren; VA Bowes; AK Gregorakis; Eric H Holmes; AL Boynton
Comparison of serum PSMA, PSA levels with results of Cytogen-356 ProstaScint scanning in prostatic cancer patients.
The Prostate 1997;33(4):281-5.
1997: GP Murphy; MJ Troychak; Oliver E Cobb; VA Bowes; R J Kenny; RJ Barren; GM Kenny; Haakon Ragde; Eric H Holmes; R L Wolfert
Evaluation of PSA, free PSA, PSMA, and total and bone alkaline phosphatase levels compared to bone scans in the management of patients with metastatic prostate cancer.
The Prostate 1997;33(2):141-6.
1997: Mark R Stroud; Eric H Holmes
Fucosylation of complex glycosphingolipids by recombinant fucosyltransferase-VII.
Biochemical and biophysical research communications 1997;238(1):165-8.
1997: RJ Barren; Eric H Holmes; AL Boynton; S L Misrock; GP Murphy
Monoclonal antibody 7E11.C5 staining of viable LNCaP cells.
The Prostate 1997;30(1):65-8.
1996: G P Murphy; RJ Barren; S J Erickson; VA Bowes; R L Wolfert; Georg Bartsch; Helmut Klocker; J Pointner; A Reissigl; David G McLeod; T Douglas; T Morgan; GM Kenny; Haakon Ragde; A L Boynton; Eric H Holmes
Evaluation and comparison of two new prostate carcinoma markers. Free-prostate specific antigen and prostate specific membrane antigen.
Cancer 1996;78(4):809-18.
1996: G P Murphy; W T Tino; Eric H Holmes; A L Boynton; S J Erickson; VA Bowes; RJ Barren; Benjamin A Tjoa; S L Misrock; Haakon Ragde; GM Kenny
Measurement of prostate-specific membrane antigen in the serum with a new antibody.
The Prostate 1996;28(4):266-71.
1995: Eric H Holmes; Z Xu; Anne L Sherwood; Bruce A Macher
Structure-function analysis of human alpha 1-->3fucosyltransferases. A GDP-fucose-protected, N-ethylmaleimide-sensitive site in FucT-III and FucT-V corresponds to Ser178 in FucT-IV.
The Journal of biological chemistry 1995;270(14):8145-51.
1995: G P Murphy; Eric H Holmes; A L Boynton; GM Kenny; R C Ostenson; S J Erickson; RJ Barren
Comparison of prostate specific antigen, prostate specific membrane antigen, and LNCaP-based enzyme-linked immunosorbent assays in prostatic cancer patients and patients with benign prostatic enlargement.
The Prostate 1995;26(3):164-8.
1994: Y P Rochon; J S Horoszewicz; A L Boynton; Eric H Holmes; RJ Barren; S J Erickson; GM Kenny; G P Murphy
Western blot assay for prostate-specific membrane antigen in serum of prostate cancer patients.
The Prostate 1994;25(4):219-23.
1994: J Hu; C L Stults; Eric H Holmes; Bruce A Macher
Structural characterization of intermediates in the biosynthetic pathway of neolacto glycosphingolipids: differential expression in human leukaemia cells.
Glycobiology 1994;4(3):251-7.
1993: Eric H Holmes; T G Greene
De novo synthesis of type 1 lacto-series glycolipids in human colonic adenocarcinoma cells: efficient synthesis of the Le(a) antigen and absence of brefeldin A-induced inhibition of its synthesis in Colo 205 cells.
Archives of biochemistry and biophysics 1993;305(2):328-40.
1993: Eric H Holmes; Bruce A Macher
Specificity of fucose transfer to GlcNAc residues of extended chain neolacto-series glycolipids catalyzed by human alpha 1-->3fucosyltransferases: effect of the lipidic environment on the myeloid enzyme form.
Archives of biochemistry and biophysics 1993;301(1):190-9.
1993: Eric H Holmes
Human Lewis alpha 1-->3/4fucosyltransferase: specificity of fucose transfer to GlcNAc beta 1-->3Gal beta 1-->4Glc beta 1-->1Cer (LcOse3Cer).
Glycobiology 1993;3(1):77-81.
1992: Anne L Sherwood; Eric H Holmes
Brefeldin A induced inhibition of de novo globo- and neolacto-series glycolipid core chain biosynthesis in human cells. Evidence for an effect on beta 1-->4galactosyltransferase activity.
The Journal of biological chemistry 1992;267(35):25328-36.
1992: Anne L Sherwood; T G Greene; Eric H Holmes
Stable expression of a cDNA encoding a human beta 1 --> 3galactosyltransferase responsible for lacto-series type 1 core chain synthesis in non-expressing cells: variation in the nature of cell surface antigens expressed.
Journal of cellular biochemistry 1992;50(2):165-77.
1992: Eric H Holmes
Presence of an essential lysine residue in a GDP-fucose protected site of the alpha 1----3fucosyltransferase from human small cell lung carcinoma NCl-H69 cells.
Archives of biochemistry and biophysics 1992;296(2):562-8.
1991: Bruce A Macher; Eric H Holmes; S J Swiedler; C L Stults; C A Srnka
Human alpha 1-3 fucosyltransferases.
Glycobiology 1991;1(6):577-84.
1991: Eric H Holmes; T G Greene
Isolation and fine-structure characterization of four monoclonal antibodies reactive with glycoconjugates containing terminal GlcNAc residues: application to aspects of lacto-series tumor antigen biosynthesis.
Archives of biochemistry and biophysics 1991;288(1):87-96.
1991: G K Ostrander; M Bozlee; M Fukuda; A Dell; J E Thomas-Oates; Steven B Levery; H L Eaton; S Hakomori; Eric H Holmes
Isolation and characterization of the major glycosphingolipids from the liver of the rainbow trout (Oncorhynchus mykiss): identification of an abundant source of 9-O-acetyl GD3.
Archives of biochemistry and biophysics 1991;284(2):413-21.
1991: G K Ostrander; Eric H Holmes
Characterization of a CMPNeuAc: lactosylceramide alpha 2----3sialyltransferase from rainbow trout hepatoma (RTH-149) cells.
Comparative biochemistry and physiology. B, Comparative biochemistry 1991;98(1):87-95.
1990: N K Jenner; G K Ostrander; Terrance J Kavanagh; John Livesey; M W Shen; S C Kim; Eric H Holmes
A flow cytometric comparison of DNA content and glutathione levels in hepatocytes of English sole (Parophyrs vetulus) from areas of differing water quality.
Archives of environmental contamination and toxicology 1990;19(6):807-15.
1990: Eric H Holmes; T G Greene
Alteration of lacto-series glycolipid glycosyltransferase activities in human colonic adenocarcinoma DLD-1 cells after culture in N,N-dimethylformamide-containing medium.
Journal of cellular biochemistry 1990;44(2):93-105.
1990: Eric H Holmes
Photoaffinity labeling of GDP-fucose:nLcOse4Cer alpha 1----3-fucosyltransferase from human small cell lung carcinoma NCI-H69 cells with the GDP-fucose analog GDP-hexanolaminyl-4-azidosalicylic acid.
The Journal of biological chemistry 1990;265(22):13150-6.
1990: Eric H Holmes; T G Greene
Characterization of two monoclonal antibodies specific for lacto-series type 1 chain Gal beta 1----3GlcNAc-terminal structures.
Archives of biochemistry and biophysics 1990;277(1):181-8.
1990: Eric H Holmes
GDP-fucose:GM1 alpha 1----2fucosyltransferase is activated in parenchymal cells of rat liver during early stages of N-2-acetylaminofluorene induced hepatocarcinogenesis.
Carcinogenesis 1990;11(1):89-94.
1990: N K Jenner; Eric H Holmes
Glycolipid biosynthesis in rainbow trout: characterization of a beta 1----4galactosyltransferase independent from regulation by alpha-lactalbumin.
Comparative biochemistry and physiology. B, Comparative biochemistry 1990;96(4):689-96.
1989: Eric H Holmes; Steven B Levery
Biosynthesis of fucose containing lacto-series glycolipids in human colonic adenocarcinoma Colo 205 cells.
Archives of biochemistry and biophysics 1989;274(2):633-47.
1989: Eric H Holmes; Steven B Levery
Preparative in vitro generation of lacto-series type 1 chain glycolipids catalyzed by beta 1----3-galactosyltransferase from human colonic adenocarcinoma Colo 205 cells.
Archives of biochemistry and biophysics 1989;274(1):14-25.
1989: Eric H Holmes
Characterization and membrane organization of beta 1----3- and beta 1----4-galactosyltransferases from human colonic adenocarcinoma cell lines Colo 205 and SW403: basis for preferential synthesis of type 1 chain lacto-series carbohydrate structures.
Archives of biochemistry and biophysics 1989;270(2):630-46.
1988: G K Ostrander; Steven B Levery; H L Eaton; M E Salyan; S Hakomori; Eric H Holmes
Isolation and characterization of four major neutral glycosphingolipids from the liver of the English sole (Parophrys vetulus). Presence of a novel branched lacto-ganglio-iso-globo hybrid structure.
The Journal of biological chemistry 1988;263(35):18716-25.
1988: G K Ostrander; Steven B Levery; S Hakomori; Eric H Holmes
Isolation and characterization of the major acidic glycosphingolipids from the liver of the English sole (Parophrys vetulus). Presence of a novel ganglioside with a Forssman antigen determinant.
The Journal of biological chemistry 1988;263(7):3103-10.
1988: Eric H Holmes
Characterization of a beta 1----3-N-acetylglucosaminyltransferase associated with synthesis of type 1 and type 2 lacto-series tumor-associated antigens from the human colonic adenocarcinoma cell line SW403.
Archives of biochemistry and biophysics 1988;260(1):461-8.
1987: Eric H Holmes; S Hakomori; G K Ostrander
Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.
The Journal of biological chemistry 1987;262(32):15649-58.
1987: Eric H Holmes; G K Ostrander; H Clausen; N Graem
Oncofetal expression of Lex carbohydrate antigens in human colonic adenocarcinomas. Regulation through type 2 core chain synthesis rather than fucosylation.
The Journal of biological chemistry 1987;262(23):11331-8.
1987: Eric H Holmes; S Hakomori
The chemical carcinogen-induced enzyme, GDP-fucose: GM1 alpha 1----2 fucosyltransferase in rat liver and hepatoma: modulation by and association with phospholipids.
Journal of biochemistry 1987;101(5):1095-105.
1986: Eric H Holmes; G K Ostrander; S Hakomori
Biosynthesis of the sialyl-Lex determinant carried by type 2 chain glycosphingolipids (IV3NeuAcIII3FucnLc4, VI3NeuAcV3FucnLc6, and VI3NeuAcIII3V3Fuc2nLc6) in human lung carcinoma PC9 cells.
The Journal of biological chemistry 1986;261(8):3737-43.
1985: Eric H Holmes; G K Ostrander; S Hakomori
Enzymatic basis for the accumulation of glycolipids with X and dimeric X determinants in human lung cancer cells (NCI-H69).
The Journal of biological chemistry 1985;260(12):7619-27.