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Randall Holmes

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Gregory A Price; Kim McFann; Randall K Holmes
Immunization with cholera toxin B subunit induces high-level protection in the suckling mouse model of cholera.
Michael G Jobling; Wendy R Kam; Wayne I Lencer; Zhijie Yang; Randall K Holmes
A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway.
Gregory A Price; Randall K Holmes
Evaluation of TcpF-A2-CTB chimera and evidence of additive protective efficacy of immunizing with TcpF and CTB in the suckling mouse model of cholera.

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All Publications

2013: Gregory A Price; Kim McFann; Randall K Holmes
Immunization with cholera toxin B subunit induces high-level protection in the suckling mouse model of cholera.
PloS one 2013;8(2):e57269.
2012: Michael G Jobling; Wendy R Kam; Wayne I Lencer; Zhijie Yang; Randall K Holmes
A single native ganglioside GM1-binding site is sufficient for cholera toxin to bind to cells and complete the intoxication pathway.
mBio 2012;3(6):.
2012: Gregory A Price; Randall K Holmes
Evaluation of TcpF-A2-CTB chimera and evidence of additive protective efficacy of immunizing with TcpF and CTB in the suckling mouse model of cholera.
PloS one 2012;7(8):e42434.
2012: Sheryl Zajdowicz; Mark W Duncan; Jon C Haller; Robert S Hodges; Stephen W Hunsucker; David N M Jones; Amy E Krafft; Colin T Mant; Randall K Holmes
Purification and structural characterization of siderophore (corynebactin) from Corynebacterium diphtheriae.
PloS one 2012;7(4):e34591.
2012: Ju-Sim Kim; Randall K Holmes
Characterization of OxyR as a negative transcriptional regulator that represses catalase production in Corynebacterium diphtheriae.
PloS one 2012;7(3):e31709.
2011: Sheryl L W Zajdowicz; Ronald E Gill; Michael G Jobling; Jessica Jones-Carson; Andrés Vazquez-Torres; Randall K Holmes
Alanine racemase mutants of Burkholderia pseudomallei and Burkholderia mallei and use of alanine racemase as a non-antibiotic-based selectable marker.
PloS one 2011;6(6):e21523.
2010: Tuhina Banerjee; Abhay Pande; Michael G Jobling; Michael Taylor; Shane Massey; Randall K Holmes; Suren A Tatulian; Abhay Pande
Contribution of subdomain structure to the thermal stability of the cholera toxin A1 subunit.
Biochemistry 2010;49(41):8839-46.
2009: Jennifer K Spinler; Sheryl L W Zajdowicz; Jon C Haller; Diana Oram; Ronald E Gill; Randall K Holmes
Development and use of a selectable, broad-host-range reporter transposon for identifying environmentally regulated promoters in bacteria.
FEMS microbiology letters 2009;291(2):143-50.
2009: Mohamad A Hamad; Sheryl L Zajdowicz; Randall K Holmes; Martin I Voskuil
An allelic exchange system for compliant genetic manipulation of the select agents Burkholderia pseudomallei and Burkholderia mallei.
Gene 2009;430(1-2):123-31.
2008: Anne A Wolf; Michael G Jobling; David Saslowsky; Eli Kern; Kimberly R Drake; Anne K Kenworthy; Randall K Holmes; Wayne I Lencer
Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules.
Infection and immunity 2008;76(4):1476-84.
2007: Abhay Pande; Patricia Scaglione; Michael Taylor; Kathleen N Nemec; Summer Tuthill; David Moe; Randall K Holmes; Suren A Tatulian; Abhay Pande
Conformational instability of the cholera toxin A1 polypeptide.
Journal of molecular biology 2007;374(4):1114-28.
2007: Eric Schonteich; Manohar Pilli; Glenn C Simon; Hugo T Matern; Jagath R Junutula; Danielle Sentz; Randall K Holmes; Rytis Prekeris
Molecular characterization of Rab11-FIP3 binding to ARF GTPases.
European journal of cell biology 2007;86(8):417-31.
2007: M Oram; Joelle E Woolston; Andrew D Jacobson; Randall K Holmes; Diana Oram
Bacteriophage-based vectors for site-specific insertion of DNA in the chromosome of Corynebacteria.
Gene 2007;391(1-2):53-62.
2007: Goragot Wisedchaisri; C James Chou; Meiting Wu; Claudia Roach; Adrian E Rice; Randall K Holmes; Craig Beeson; Wim G J Hol
Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis.
Biochemistry 2007;46(2):436-47.
2006: Diana Oram; Andrew D Jacobson; Randall K Holmes
Transcription of the contiguous sigB, dtxR, and galE genes in Corynebacterium diphtheriae: evidence for multiple transcripts and regulation by environmental factors.
Journal of bacteriology 2006;188(8):2959-73.
2006: Ken Teter; Michael G Jobling; Danielle Sentz; Randall K Holmes
The cholera toxin A1(3) subdomain is essential for interaction with ADP-ribosylation factor 6 and full toxic activity but is not required for translocation from the endoplasmic reticulum to the cytosol.
Infection and immunity 2006;74(4):2259-67.
2006: Megan W Howard; Brian Tripet; Michael G Jobling; Randall K Holmes; Kathryn V Holmes; Robert S Hodges
Dissection of the fusion machine of SARS-coronavirus.
Advances in experimental medicine and biology 2006;581():319-22.
2005: Claire J O'Neal; Michael G Jobling; Randall K Holmes; Wim G J Hol
Structural basis for the activation of cholera toxin by human ARF6-GTP.
Science (New York, N.Y.) 2005;309(5737):1093-6.
2005: Lina Guerra; Ken Teter; Brendan N Lilley; Bo Stenerlöw; Randall K Holmes; Hidde L Ploegh; Kirsten Sandvig; Monica Thelestam; Teresa Frisan
Cellular internalization of cytolethal distending toxin: a new end to a known pathway.
Cellular microbiology 2005;7(7):921-34.
2005: Juliette K Tinker; Jarrod L Erbe; Randall K Holmes
Characterization of fluorescent chimeras of cholera toxin and Escherichia coli heat-labile enterotoxins produced by use of the twin arginine translocation system.
Infection and immunity 2005;73(6):3627-35.
2005: Diana Oram; Lisa M Must; Jennifer K Spinler; Edda M Twiddy; Randall K Holmes
Analysis of truncated variants of the iron dependent transcriptional regulators from Corynebacterium diphtheriae and Mycobacterium tuberculosis.
FEMS microbiology letters 2005;243(1):1-8.
2004: Carlos Gorbea; Geoffrey M Goellner; Ken Teter; Randall K Holmes; Martin Rechsteiner
Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles.
The Journal of biological chemistry 2004;279(52):54849-61.
2004: C James Chou; Goragot Wisedchaisri; Ryan R Monfeli; Diana Oram; Randall K Holmes; Wim G J Hol; Craig Beeson
Functional studies of the Mycobacterium tuberculosis iron-dependent regulator.
The Journal of biological chemistry 2004;279(51):53554-61.
2004: Xin Li; Jarrod L Erbe; C Virginia Lockatell; David E Johnson; Michael G Jobling; Randall K Holmes; harry mobley
Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis.
Infection and immunity 2004;72(12):7306-10.
2004: Ken Teter; Michael G Jobling; Randall K Holmes
Vesicular transport is not required for the cytoplasmic pool of cholera toxin to interact with the stimulatory alpha subunit of the heterotrimeric g protein.
Infection and immunity 2004;72(12):6826-35.
2004: Goragot Wisedchaisri; Randall K Holmes; Wim G J Hol
Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions.
Journal of molecular biology 2004;342(4):1155-69.
2004: Brian Tripet; Megan W Howard; Michael Jobling; Randall K Holmes; Kathryn V Holmes; Robert S Hodges
Structural characterization of the SARS-coronavirus spike S fusion protein core.
The Journal of biological chemistry 2004;279(20):20836-49.
2004: Claire J O'Neal; Edward I Amaya; Michael G Jobling; Randall K Holmes; Wim G J Hol
Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism.
Biochemistry 2004;43(13):3772-82.
2004: Diana Oram; Ana Avdalovic; Randall K Holmes
Analysis of genes that encode DtxR-like transcriptional regulators in pathogenic and saprophytic corynebacterial species.
Infection and immunity 2004;72(4):1885-95.
2003: Yukako Fujinaga; Anne A Wolf; Chiara Rodighiero; Heidi E Wheeler; Billy Tsai; Larry Allen; Michael G Jobling; Tom A Rapoport; Randall K Holmes; Wayne I Lencer
Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm.
Molecular biology of the cell 2003;14(12):4783-93.
2003: Juliette K Tinker; Jarrod L Erbe; Wim G J Hol; Randall K Holmes
Cholera holotoxin assembly requires a hydrophobic domain at the A-B5 interface: mutational analysis and development of an in vitro assembly system.
Infection and immunity 2003;71(7):4093-101.
2003: Ken Teter; Michael G Jobling; Randall K Holmes
A class of mutant CHO cells resistant to cholera toxin rapidly degrades the catalytic polypeptide of cholera toxin and exhibits increased endoplasmic reticulum-associated degradation.
Traffic (Copenhagen, Denmark) 2003;4(4):232-42.
2002: Ken Teter; Randall K Holmes
Inhibition of endoplasmic reticulum-associated degradation in CHO cells resistant to cholera toxin, Pseudomonas aeruginosa exotoxin A, and ricin.
Infection and immunity 2002;70(11):6172-9.
2002: Ken Teter; Rebecca L Allyn; Michael G Jobling; Randall K Holmes
Transfer of the cholera toxin A1 polypeptide from the endoplasmic reticulum to the cytosol is a rapid process facilitated by the endoplasmic reticulum-associated degradation pathway.
Infection and immunity 2002;70(11):6166-71.
2002: Diana Oram; Ana Avdalovic; Randall K Holmes
Construction and characterization of transposon insertion mutations in Corynebacterium diphtheriae that affect expression of the diphtheria toxin repressor (DtxR).
Journal of bacteriology 2002;184(20):5723-32.
2002: Yilei Qian; John H Lee; Randall K Holmes
Identification of a DtxR-regulated operon that is essential for siderophore-dependent iron uptake in Corynebacterium diphtheriae.
Journal of bacteriology 2002;184(17):4846-56.
2002: Michael G Jobling; Randall K Holmes
Mutational analysis of ganglioside GM(1)-binding ability, pentamer formation, and epitopes of cholera toxin B (CTB) subunits and CTB/heat-labile enterotoxin B subunit chimeras.
Infection and immunity 2002;70(3):1260-71.
2001: S Wimer-Mackin; Randall K Holmes; Anne A Wolf; Wayne I Lencer; Michael G Jobling
Characterization of receptor-mediated signal transduction by Escherichia coli type IIa heat-labile enterotoxin in the polarized human intestinal cell line T84.
Infection and immunity 2001;69(12):7205-12.
2001: Michael G Jobling; Randall K Holmes
Biological and biochemical characterization of variant A subunits of cholera toxin constructed by site-directed mutagenesis.
Journal of bacteriology 2001;183(13):4024-32.
2001: E Pohl; Joanne Goranson-Siekierke; M K Choi; T Roosild; Randall K Holmes; Wim G J Hol
Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 5):619-27.
2001: M D Feese; B P Ingason; Joanne Goranson-Siekierke; Randall K Holmes; Wim G J Hol
Crystal structure of the iron-dependent regulator from Mycobacterium tuberculosis at 2.0-A resolution reveals the Src homology domain 3-like fold and metal binding function of the third domain.
The Journal of biological chemistry 2001;276(8):5959-66.
2000: Michael G Jobling; Randall K Holmes
Identification of motifs in cholera toxin A1 polypeptide that are required for its interaction with human ADP-ribosylation factor 6 in a bacterial two-hybrid system.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14662-7.
2000: Kamran Badizadegan; Anne A Wolf; Chiara Rodighiero; Michael G Jobling; Timothy R Hirst; Randall K Holmes; Wayne I Lencer
Floating cholera toxin into epithelial cells: functional association with caveolae-like detergent-insoluble membrane microdomains.
International journal of medical microbiology : IJMM 2000;290(4-5):403-8.
2000: Kamran Badizadegan; Bonny L Dickinson; Heidi E Wheeler; Richard S Blumberg; Randall K Holmes; Wayne I Lencer
Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1).
American journal of physiology. Gastrointestinal and liver physiology 2000;278(6):G895-904.
2000: Randall K Holmes
Biology and molecular epidemiology of diphtheria toxin and the tox gene.
The Journal of infectious diseases 2000;181 Suppl 1():S156-67.
2000: John H Lee; Randall K Holmes
Characterization of specific nucleotide substitutions in DtxR-specific operators of Corynebacterium diphtheriae that dramatically affect DtxR binding, operator function, and promoter strength.
Journal of bacteriology 2000;182(2):432-8.
1999: E Pohl; Randall K Holmes; Wim G J Hol
Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain.
Journal of molecular biology 1999;292(3):653-67.
1999: Wayne I Lencer; Timothy R Hirst; Randall K Holmes
Membrane traffic and the cellular uptake of cholera toxin.
Biochimica et biophysica acta 1999;1450(3):177-90.
1999: Joanne Goranson-Siekierke; E Pohl; Wim G J Hol; Randall K Holmes
Anion-coordinating residues at binding site 1 are essential for the biological activity of the diphtheria toxin repressor.
Infection and immunity 1999;67(4):1806-11.
1999: E Pohl; Randall K Holmes; Wim G J Hol
Crystal structure of the iron-dependent regulator (IdeR) from Mycobacterium tuberculosis shows both metal binding sites fully occupied.
Journal of molecular biology 1999;285(3):1145-56.
1998: Ethan A Merritt; P Kuhn; S Sarfaty; Jarrod L Erbe; Randall K Holmes; Wim G J Hol
The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site.
Journal of molecular biology 1998;282(5):1043-59.
1998: E Pohl; Randall K Holmes; Wim G J Hol
Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR.
The Journal of biological chemistry 1998;273(35):22420-7.
1998: Anne A Wolf; Michael G Jobling; S Wimer-Mackin; M Ferguson-Maltzman; James L Madara; Randall K Holmes; Wayne I Lencer
Ganglioside structure dictates signal transduction by cholera toxin and association with caveolae-like membrane domains in polarized epithelia.
The Journal of cell biology 1998;141(4):917-27.
1998: F Sultan; L L Jin; M G Jobling; Randall K Holmes; Samuel L Stanley
Mucosal immunogenicity of a holotoxin-like molecule containing the serine-rich Entamoeba histolytica protein (SREHP) fused to the A2 domain of cholera toxin.
Infection and immunity 1998;66(2):462-8.
1997: M G Jobling; Randall K Holmes
Characterization of hapR, a positive regulator of the Vibrio cholerae HA/protease gene hap, and its identification as a functional homologue of the Vibrio harveyi luxR gene.
Molecular microbiology 1997;26(5):1023-34.
1997: Mischel P Schmitt; B G Talley; Randall K Holmes
Characterization of lipoprotein IRP1 from Corynebacterium diphtheriae, which is regulated by the diphtheria toxin repressor (DtxR) and iron.
Infection and immunity 1997;65(12):5364-7.
1997: John H Lee; T Wang; K Ault; J Liu; Mischel P Schmitt; Randall K Holmes
Identification and characterization of three new promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron.
Infection and immunity 1997;65(10):4273-80.
1997: Ethan A Merritt; S Sarfaty; Michael G Jobling; T Chang; Randall K Holmes; Timothy R Hirst; Wim G J Hol
Structural studies of receptor binding by cholera toxin mutants.
Protein science : a publication of the Protein Society 1997;6(7):1516-28.
1997: Wayne I Lencer; C Constable; S Moe; Paul A Rufo; A Wolf; Michael G Jobling; S P Ruston; James L Madara; Randall K Holmes; Timothy R Hirst
Proteolytic activation of cholera toxin and Escherichia coli labile toxin by entry into host epithelial cells. Signal transduction by a protease-resistant toxin variant.
The Journal of biological chemistry 1997;272(24):15562-8.
1997: E Pohl; X Qui; L M Must; Randall K Holmes; Wim G J Hol
Comparison of high-resolution structures of the diphtheria toxin repressor in complex with cobalt and zinc at the cation-anion binding site.
Protein science : a publication of the Protein Society 1997;6(5):1114-8.
1997: Michael G Jobling; L M Palmer; Jarrod L Erbe; Randall K Holmes
Construction and characterization of versatile cloning vectors for efficient delivery of native foreign proteins to the periplasm of Escherichia coli.
Plasmid 1997;38(3):158-73.
1996: X Qiu; E Pohl; Randall K Holmes; Wim G J Hol
High-resolution structure of the diphtheria toxin repressor complexed with cobalt and manganese reveals an SH3-like third domain and suggests a possible role of phosphate as co-corepressor.
Biochemistry 1996;35(38):12292-302.
1996: Focco Van Den Akker; S Sarfaty; E M Twiddy; T D Connell; Randall K Holmes; Wim G J Hol
Crystal structure of a new heat-labile enterotoxin, LT-IIb.
Structure (London, England : 1993) 1996;4(6):665-78.
1995: M P Schmitt; M Predich; L Doukhan; Issar Smith; Randall K Holmes
Characterization of an iron-dependent regulatory protein (IdeR) of Mycobacterium tuberculosis as a functional homolog of the diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae.
Infection and immunity 1995;63(11):4284-9.
1995: Wayne I Lencer; C Constable; S Moe; Michael G Jobling; H M Webb; S Ruston; James L Madara; Timothy R Hirst; Randall K Holmes
Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.
The Journal of cell biology 1995;131(4):951-62.
1995: Ethan A Merritt; S Sarfaty; T T Chang; L M Palmer; Michael G Jobling; Randall K Holmes; Wim G J Hol
Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants.
Structure (London, England : 1993) 1995;3(6):561-70.
1995: T D Connell; Randall K Holmes
Mutational analysis of the ganglioside-binding activity of the type II Escherichia coli heat-labile enterotoxin LT-IIb.
Molecular microbiology 1995;16(1):21-31.
1995: X Qiu; Christophe Verlinde; S Zhang; M P Schmitt; Randall K Holmes; Wim G J Hol
Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors.
Structure (London, England : 1993) 1995;3(1):87-100.
1994: Z Wang; M P Schmitt; Randall K Holmes
Characterization of mutations that inactivate the diphtheria toxin repressor gene (dtxR).
Infection and immunity 1994;62(5):1600-8.
1994: M P Schmitt; Randall K Holmes
Cloning, sequence, and footprint analysis of two promoter/operators from Corynebacterium diphtheriae that are regulated by the diphtheria toxin repressor (DtxR) and iron.
Journal of bacteriology 1994;176(4):1141-9.
1993: M P Schmitt; Randall K Holmes
Analysis of diphtheria toxin repressor-operator interactions and characterization of a mutant repressor with decreased binding activity for divalent metals.
Molecular microbiology 1993;9(1):173-81.
1992: M G Jobling; Randall K Holmes
Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras.
Infection and immunity 1992;60(11):4915-24.
1992: M P Schmitt; E M Twiddy; Randall K Holmes
Purification and characterization of the diphtheria toxin repressor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7576-80.
1992: A E Krafft; S P Tai; Christopher Coker; Randall K Holmes
Transcription analysis and nucleotide sequence of tox promoter/operator mutants of corynebacteriophage beta.
Microbial pathogenesis 1992;13(2):85-92.
1992: T D Connell; Randall K Holmes
Characterization of hybrid toxins produced in Escherichia coli by assembly of A and B polypeptides from type I and type II heat-labile enterotoxins.
Infection and immunity 1992;60(4):1653-61.
1992: M L Francis; J Ryan; M G Jobling; Randall K Holmes; J Moss; James J Mond
Cyclic AMP-independent effects of cholera toxin on B cell activation. II. Binding of ganglioside GM1 induces B cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(7):1999-2005.
1992: T D Connell; Randall K Holmes
Molecular genetic analysis of ganglioside GD1b-binding activity of Escherichia coli type IIa heat-labile enterotoxin by use of random and site-directed mutagenesis.
Infection and immunity 1992;60(1):63-70.
1991: M P Schmitt; Randall K Holmes
Characterization of a defective diphtheria toxin repressor (dtxR) allele and analysis of dtxR transcription in wild-type and mutant strains of Corynebacterium diphtheriae.
Infection and immunity 1991;59(11):3903-8.
1991: M G Jobling; Randall K Holmes
Analysis of structure and function of the B subunit of cholera toxin by the use of site-directed mutagenesis.
Molecular microbiology 1991;5(7):1755-67.
1991: M P Schmitt; Randall K Holmes
Iron-dependent regulation of diphtheria toxin and siderophore expression by the cloned Corynebacterium diphtheriae repressor gene dtxR in C. diphtheriae C7 strains.
Infection and immunity 1991;59(6):1899-904.
1991: C M Lee; P P Chang; S C Tsai; Ronald Adamik; S R Price; B C Kunz; Joel Moss; E M Twiddy; Randall K Holmes
Activation of Escherichia coli heat-labile enterotoxins by native and recombinant adenosine diphosphate-ribosylation factors, 20-kD guanine nucleotide-binding proteins.
The Journal of clinical investigation 1991;87(5):1780-6.
1991: L P Perera; J E Samuel; Randall K Holmes; Alison D O'Brien
Mapping the minimal contiguous gene segment that encodes functionally active Shiga-like toxin II.
Infection and immunity 1991;59(3):829-35.
1991: L P Perera; J E Samuel; Randall K Holmes; Alison D O'Brien
Identification of three amino acid residues in the B subunit of Shiga toxin and Shiga-like toxin type II that are essential for holotoxin activity.
Journal of bacteriology 1991;173(3):1151-60.
1990: L M Sung; M P Jackson; Alison D O'Brien; Randall K Holmes
Transcription of the Shiga-like toxin type II and Shiga-like toxin type II variant operons of Escherichia coli.
Journal of bacteriology 1990;172(11):6386-95.
1990: S P Tai; A E Krafft; P Nootheti; Randall K Holmes
Coordinate regulation of siderophore and diphtheria toxin production by iron in Corynebacterium diphtheriae.
Microbial pathogenesis 1990;9(4):267-73.
1990: M G Jobling; Randall K Holmes
Construction of vectors with the p15a replicon, kanamycin resistance, inducible lacZ alpha and pUC18 or pUC19 multiple cloning sites.
Nucleic acids research 1990;18(17):5315-6.
1990: H Marcus; J M Ketley; James B Kaper; Randall K Holmes
Effects of DNase production, plasmid size, and restriction barriers on transformation of Vibrio cholerae by electroporation and osmotic shock.
FEMS microbiology letters 1990;56(1-2):149-54.
1990: M P Jackson; E A Wadolkowski; DL Weinstein; Randall K Holmes; Alison D O'Brien
Functional analysis of the Shiga toxin and Shiga-like toxin type II variant binding subunits by using site-directed mutagenesis.
Journal of bacteriology 1990;172(2):653-8.
1989: DL Weinstein; M P Jackson; L P Perera; Randall K Holmes; Alison D O'Brien
In vivo formation of hybrid toxins comprising Shiga toxin and the Shiga-like toxins and role of the B subunit in localization and cytotoxic activity.
Infection and immunity 1989;57(12):3743-50.
1989: C L Pickett; E M Twiddy; Christopher Coker; Randall K Holmes
Cloning, nucleotide sequence, and hybridization studies of the type IIb heat-labile enterotoxin gene of Escherichia coli.
Journal of bacteriology 1989;171(9):4945-52.
1989: Alison D O'Brien; L R Marques; C F Kerry; J W Newland; Randall K Holmes
Shiga-like toxin converting phage of enterohemorrhagic Escherichia coli strain 933.
Microbial pathogenesis 1989;6(5):381-90.
1988: DL Weinstein; M P Jackson; J E Samuel; Randall K Holmes; Alison D O'Brien
Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine.
Journal of bacteriology 1988;170(9):4223-30.
1988: S P Tai; Randall K Holmes
Iron regulation of the cloned diphtheria toxin promoter in Escherichia coli.
Infection and immunity 1988;56(9):2430-6.
1988: S Fukuta; J L Magnani; E M Twiddy; Randall K Holmes; V Ginsburg
Comparison of the carbohydrate-binding specificities of cholera toxin and Escherichia coli heat-labile enterotoxins LTh-I, LT-IIa, and LT-IIb.
Infection and immunity 1988;56(7):1748-53.
1988: N A Strockbine; M P Jackson; L M Sung; Randall K Holmes; Alison D O'Brien
Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1.
Journal of bacteriology 1988;170(3):1116-22.
1988: DL Weinstein; Randall K Holmes; Alison D O'Brien
Effects of iron and temperature on Shiga-like toxin I production by Escherichia coli.
Infection and immunity 1988;56(1):106-11.
1987: C L Pickett; DL Weinstein; Randall K Holmes
Genetics of type IIa heat-labile enterotoxin of Escherichia coli: operon fusions, nucleotide sequence, and hybridization studies.
Journal of bacteriology 1987;169(11):5180-7.
1987: P P Chang; Joel Moss; E M Twiddy; Randall K Holmes
Type II heat-labile enterotoxin of Escherichia coli activates adenylate cyclase in human fibroblasts by ADP ribosylation.
Infection and immunity 1987;55(8):1854-8.
1987: M P Jackson; J W Newland; Randall K Holmes; Alison D O'Brien
Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coli.
Microbial pathogenesis 1987;2(2):147-53.
1986: B E Guth; C L Pickett; E M Twiddy; Randall K Holmes; Tania Gomes; A A Lima; R L Guerrant; B D Franco; Luiz R Trabulsi
Production of type II heat-labile enterotoxin by Escherichia coli isolated from food and human feces.
Infection and immunity 1986;54(2):587-9.
1986: B E Guth; E M Twiddy; Luiz R Trabulsi; Randall K Holmes
Variation in chemical properties and antigenic determinants among type II heat-labile enterotoxins of Escherichia coli.
Infection and immunity 1986;54(2):529-36.
1986: Randall K Holmes; E M Twiddy; C L Pickett
Purification and characterization of type II heat-labile enterotoxin of Escherichia coli.
Infection and immunity 1986;53(3):464-73.
1986: N A Strockbine; L R Marques; J W Newland; H W Smith; Randall K Holmes; Alison D O'Brien
Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities.
Infection and immunity 1986;53(1):135-40.
1986: C L Pickett; E M Twiddy; B W Belisle; Randall K Holmes
Cloning of genes that encode a new heat-labile enterotoxin of Escherichia coli.
Journal of bacteriology 1986;165(2):348-52.
1985: N A Strockbine; L R Marques; Randall K Holmes; Alison D O'Brien
Characterization of monoclonal antibodies against Shiga-like toxin from Escherichia coli.
Infection and immunity 1985;50(3):695-700.
1985: J W Newland; N A Strockbine; S F Miller; Alison D O'Brien; Randall K Holmes
Cloning of Shiga-like toxin structural genes from a toxin converting phage of Escherichia coli.
Science (New York, N.Y.) 1985;230(4722):179-81.
1984: B W Belisle; E M Twiddy; Randall K Holmes
Monoclonal antibodies with an expanded repertoire of specificities and potent neutralizing activity for Escherichia coli heat-labile enterotoxin.
Infection and immunity 1984;46(3):759-64.
1984: B W Belisle; E M Twiddy; Randall K Holmes
Characterization of monoclonal antibodies to heat-labile enterotoxin encoded by a plasmid from a clinical isolate of Escherichia coli.
Infection and immunity 1984;43(3):1027-32.
1983: Randall K Holmes; E M Twiddy
Characterization of monoclonal antibodies that react with unique and cross-reacting determinants of cholera enterotoxin and its subunits.
Infection and immunity 1983;42(3):914-23.
1983: R J Neill; E M Twiddy; Randall K Holmes
Synthesis of plasmid-coded heat-labile enterotoxin in wild-type and hypertoxinogenic strains of Escherichia coli and in other genera of Enterobacteriaceae.
Infection and immunity 1983;41(3):1056-61.
1981: M G Bramucci; E M Twiddy; W B Baine; Randall K Holmes
Isolation and characterization of hypertoxinogenic (htx) mutants of Escherichia coli KL320(pCG86).
Infection and immunity 1981;32(3):1034-44.